Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Substance-P receptor (Homo sapiens (Human)) | BDBM50000040 (((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Chimie Thérapeutique associé au CNRS et à l'Université René Descartes (UMR 8638) Curated by ChEMBL | Assay Description Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H]-[Pro9]-SP as radioligand | Bioorg Med Chem Lett 11: 659-61 (2001) BindingDB Entry DOI: 10.7270/Q2CJ8CR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-P receptor (Homo sapiens (Human)) | BDBM50097646 ((2-Methoxy-benzyl)-[1-(methylamino-phenyl-methyl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Chimie Thérapeutique associé au CNRS et à l'Université René Descartes (UMR 8638) Curated by ChEMBL | Assay Description Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H]-[Pro9]-SP as radioligand | Bioorg Med Chem Lett 11: 659-61 (2001) BindingDB Entry DOI: 10.7270/Q2CJ8CR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Substance-P receptor (Homo sapiens (Human)) | BDBM50097647 ((3,5-Bis-trifluoromethyl-benzyl)-[1-(methylamino-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | 620 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Chimie Thérapeutique associé au CNRS et à l'Université René Descartes (UMR 8638) Curated by ChEMBL | Assay Description Binding affinity towards Tachykinin receptor 1 expressed in CHO cells using [3H]-[Pro9]-SP as radioligand | Bioorg Med Chem Lett 11: 659-61 (2001) BindingDB Entry DOI: 10.7270/Q2CJ8CR0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 2 (Homo sapiens (Human)) | BDBM50197103 ((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Inhibition of human EAAT2 expressed in HEK293 cells by FLIPR membrane potential assay | J Med Chem 49: 6532-8 (2006) Article DOI: 10.1021/jm060822s BindingDB Entry DOI: 10.7270/Q2S46RMK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 3 (Homo sapiens (Human)) | BDBM50197103 ((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay | J Med Chem 49: 6532-8 (2006) Article DOI: 10.1021/jm060822s BindingDB Entry DOI: 10.7270/Q2S46RMK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 2 (Homo sapiens (Human)) | BDBM50197104 ((2S,1'R,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Inhibition of human EAAT2 expressed in HEK293 cells by FLIPR membrane potential assay | J Med Chem 49: 6532-8 (2006) Article DOI: 10.1021/jm060822s BindingDB Entry DOI: 10.7270/Q2S46RMK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 3 (Homo sapiens (Human)) | BDBM50197104 ((2S,1'R,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay | J Med Chem 49: 6532-8 (2006) Article DOI: 10.1021/jm060822s BindingDB Entry DOI: 10.7270/Q2S46RMK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 3 (Homo sapiens (Human)) | BDBM50197105 ((2S,1'S,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential assay | J Med Chem 49: 6532-8 (2006) Article DOI: 10.1021/jm060822s BindingDB Entry DOI: 10.7270/Q2S46RMK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 2 (Homo sapiens (Human)) | BDBM50197105 ((2S,1'S,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.10E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Inhibition of human EAAT2 expressed in HEK293 cells by FLIPR membrane potential assay | J Med Chem 49: 6532-8 (2006) Article DOI: 10.1021/jm060822s BindingDB Entry DOI: 10.7270/Q2S46RMK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 1 (Homo sapiens (Human)) | BDBM50197105 ((2S,1'S,2'R)-2-(2'-Carboxycyclobutyl)glycine | CHE...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Inhibition of human EAAT1 expressed in HEK293 cells by FLIPR membrane potential assay | J Med Chem 49: 6532-8 (2006) Article DOI: 10.1021/jm060822s BindingDB Entry DOI: 10.7270/Q2S46RMK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Excitatory amino acid transporter 1 (Homo sapiens (Human)) | BDBM50197103 ((2S,1'R,2'S)-2-(2'-Carboxycyclobutyl)glycine | CHE...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Danish University of Pharmaceutical Sciences Curated by ChEMBL | Assay Description Inhibition of human EAAT1 expressed in HEK293 cells by FLIPR membrane potential assay | J Med Chem 49: 6532-8 (2006) Article DOI: 10.1021/jm060822s BindingDB Entry DOI: 10.7270/Q2S46RMK | |||||||||||
More data for this Ligand-Target Pair |