Found 42 hits with Last Name = 'alvarez-builla' and Initial = 'j' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50445988
(CHEMBL3103124)Show SMILES Oc1cc2[nH]cc(C(=O)CN3CCC(Cc4ccccc4)CC3)c2cc1O Show InChI InChI=1S/C22H24N2O3/c25-20-11-17-18(13-23-19(17)12-21(20)26)22(27)14-24-8-6-16(7-9-24)10-15-4-2-1-3-5-15/h1-5,11-13,16,23,25-26H,6-10,14H2 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description
Displacement of [3H]Ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex |
Bioorg Med Chem 22: 1040-8 (2014)
Article DOI: 10.1016/j.bmc.2013.12.040
BindingDB Entry DOI: 10.7270/Q29888GS |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50445989
(CHEMBL3103126)Show SMILES Oc1ccc2c(c[nH]c2c1)C(=O)CN1CCC(Cc2ccc(F)cc2)CC1 Show InChI InChI=1S/C22H23FN2O2/c23-17-3-1-15(2-4-17)11-16-7-9-25(10-8-16)14-22(27)20-13-24-21-12-18(26)5-6-19(20)21/h1-6,12-13,16,24,26H,7-11,14H2 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description
Displacement of [3H]Ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex |
Bioorg Med Chem 22: 1040-8 (2014)
Article DOI: 10.1016/j.bmc.2013.12.040
BindingDB Entry DOI: 10.7270/Q29888GS |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50445990
(CHEMBL3103129)Show SMILES CS(=O)(=O)Nc1ccc2c(c[nH]c2c1)C(=O)CN1CCC(Cc2ccc(F)cc2)CC1 Show InChI InChI=1S/C23H26FN3O3S/c1-31(29,30)26-19-6-7-20-21(14-25-22(20)13-19)23(28)15-27-10-8-17(9-11-27)12-16-2-4-18(24)5-3-16/h2-7,13-14,17,25-26H,8-12,15H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description
Displacement of [3H]Ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex |
Bioorg Med Chem 22: 1040-8 (2014)
Article DOI: 10.1016/j.bmc.2013.12.040
BindingDB Entry DOI: 10.7270/Q29888GS |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50445991
(CHEMBL3103134)Show SMILES CS(=O)(=O)Nc1ccc2c(c[nH]c2c1)C(=O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1 Show InChI InChI=1S/C23H24FN3O4S/c1-32(30,31)26-18-6-7-19-20(14-25-21(19)13-18)22(28)23(29)27-10-8-16(9-11-27)12-15-2-4-17(24)5-3-15/h2-7,13-14,16,25-26H,8-12H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description
Displacement of [3H]Ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex |
Bioorg Med Chem 22: 1040-8 (2014)
Article DOI: 10.1016/j.bmc.2013.12.040
BindingDB Entry DOI: 10.7270/Q29888GS |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50083351
((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)Show InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PDB
Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description
Displacement of [3H]Ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex |
Bioorg Med Chem 22: 1040-8 (2014)
Article DOI: 10.1016/j.bmc.2013.12.040
BindingDB Entry DOI: 10.7270/Q29888GS |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50445992
(CHEMBL3102861)Show SMILES Oc1ccc2c(c[nH]c2c1)C(=O)C(=O)N1CCC(Cc2ccc(F)cc2)CC1 Show InChI InChI=1S/C22H21FN2O3/c23-16-3-1-14(2-4-16)11-15-7-9-25(10-8-15)22(28)21(27)19-13-24-20-12-17(26)5-6-18(19)20/h1-6,12-13,15,24,26H,7-11H2 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description
Displacement of [3H]Ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex |
Bioorg Med Chem 22: 1040-8 (2014)
Article DOI: 10.1016/j.bmc.2013.12.040
BindingDB Entry DOI: 10.7270/Q29888GS |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50445993
(CHEMBL3103127)Show SMILES Oc1cc2[nH]cc(C(=O)CN3CCC(Cc4ccc(F)cc4)CC3)c2cc1O Show InChI InChI=1S/C22H23FN2O3/c23-16-3-1-14(2-4-16)9-15-5-7-25(8-6-15)13-22(28)18-12-24-19-11-21(27)20(26)10-17(18)19/h1-4,10-12,15,24,26-27H,5-9,13H2 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description
Displacement of [3H]Ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex |
Bioorg Med Chem 22: 1040-8 (2014)
Article DOI: 10.1016/j.bmc.2013.12.040
BindingDB Entry DOI: 10.7270/Q29888GS |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50445987
(CHEMBL3103125)Show SMILES Oc1ccc2[nH]cc(C(=O)CN3CCC(Cc4ccc(F)cc4)CC3)c2c1 Show InChI InChI=1S/C22H23FN2O2/c23-17-3-1-15(2-4-17)11-16-7-9-25(10-8-16)14-22(27)20-13-24-21-6-5-18(26)12-19(20)21/h1-6,12-13,16,24,26H,7-11,14H2 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description
Displacement of [3H]Ifenprodil from NMDA receptor GluN2B subunit in Wistar rat cerebral cortex |
Bioorg Med Chem 22: 1040-8 (2014)
Article DOI: 10.1016/j.bmc.2013.12.040
BindingDB Entry DOI: 10.7270/Q29888GS |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50438383
(CHEMBL2413823)Show SMILES Oc1ccc2[nH]cc(C(=O)CN3CCC(CC3)NC(=O)c3ccc(O)c(O)c3)c2c1 Show InChI InChI=1S/C22H23N3O5/c26-15-2-3-18-16(10-15)17(11-23-18)21(29)12-25-7-5-14(6-8-25)24-22(30)13-1-4-19(27)20(28)9-13/h1-4,9-11,14,23,26-28H,5-8,12H2,(H,24,30) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Messina
Curated by ChEMBL
| Assay Description
Displacement of [3H]-ifenprodil from Wistar rat cerebral cortex GluN2B after 120 mins |
Bioorg Med Chem 21: 4575-80 (2013)
Article DOI: 10.1016/j.bmc.2013.05.044
BindingDB Entry DOI: 10.7270/Q2JD4Z6H |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50216630
(CHEMBL357955)Show SMILES CC(C)c1nc(SCc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)c2ccccc2n1 Show InChI InChI=1S/C25H22N6S/c1-16(2)23-26-22-10-6-5-9-21(22)25(27-23)32-15-17-11-13-18(14-12-17)19-7-3-4-8-20(19)24-28-30-31-29-24/h3-14,16H,15H2,1-2H3,(H,28,29,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490836
(CHEMBL2349273)Show SMILES CC(C)c1nc(SCc2ccc(cc2)-c2cccc(c2)C(O)=O)c2ccccc2n1 Show InChI InChI=1S/C25H22N2O2S/c1-16(2)23-26-22-9-4-3-8-21(22)24(27-23)30-15-17-10-12-18(13-11-17)19-6-5-7-20(14-19)25(28)29/h3-14,16H,15H2,1-2H3,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490849
(CHEMBL2349298)Show SMILES CC(C)c1nc(SCc2ccc(cc2)-c2cccc(c2)-c2nnn[nH]2)c2ccccc2n1 Show InChI InChI=1S/C25H22N6S/c1-16(2)23-26-22-9-4-3-8-21(22)25(27-23)32-15-17-10-12-18(13-11-17)19-6-5-7-20(14-19)24-28-30-31-29-24/h3-14,16H,15H2,1-2H3,(H,28,29,30,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490845
(CHEMBL2349274)Show SMILES CC(C)c1nc(SCc2ccc(cc2)-c2ccc(cc2)C(O)=O)c2ccccc2n1 Show InChI InChI=1S/C25H22N2O2S/c1-16(2)23-26-22-6-4-3-5-21(22)24(27-23)30-15-17-7-9-18(10-8-17)19-11-13-20(14-12-19)25(28)29/h3-14,16H,15H2,1-2H3,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 930 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490848
(CHEMBL2349295)Show SMILES Cc1nc(SCc2ccc(cc2)-c2cccc(c2)-c2nnn[nH]2)c2ccccc2n1 Show InChI InChI=1S/C23H18N6S/c1-15-24-21-8-3-2-7-20(21)23(25-15)30-14-16-9-11-17(12-10-16)18-5-4-6-19(13-18)22-26-28-29-27-22/h2-13H,14H2,1H3,(H,26,27,28,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490835
(CHEMBL2349297)Show SMILES ClC(Cl)(Cl)c1nc(SCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ccccc2n1 Show InChI InChI=1S/C23H15Cl3N6S/c24-23(25,26)22-27-19-8-4-3-7-18(19)21(28-22)33-13-14-9-11-15(12-10-14)16-5-1-2-6-17(16)20-29-31-32-30-20/h1-12H,13H2,(H,29,30,31,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490839
(CHEMBL2349291)Show SMILES COc1cccc(CSc2nc(SCc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c3ccccc3n2)c1 Show InChI InChI=1S/C30H24N6OS2/c1-37-23-8-6-7-21(17-23)19-39-30-31-27-12-5-4-11-26(27)29(32-30)38-18-20-13-15-22(16-14-20)24-9-2-3-10-25(24)28-33-35-36-34-28/h2-17H,18-19H2,1H3,(H,33,34,35,36) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490844
(CHEMBL2349277)Show SMILES COc1cc2c(SCc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)nc(CCc3ccccc3)nc2c(OC)c1OC Show InChI InChI=1S/C33H30N6O3S/c1-40-27-19-26-29(31(42-3)30(27)41-2)34-28(18-15-21-9-5-4-6-10-21)35-33(26)43-20-22-13-16-23(17-14-22)24-11-7-8-12-25(24)32-36-38-39-37-32/h4-14,16-17,19H,15,18,20H2,1-3H3,(H,36,37,38,39) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50555693
(CHEMBL4800229)Show SMILES Oc1ccc(NC(=O)CNS(=O)(=O)c2ccccc2C(=O)NCCc2ccc(O)c(O)c2)cc1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.82E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CYP3A4 (unknown origin) in baculosomes preincubated for 20 mins followed by addition of CYP enzyme-specific substrate and NADP+ and mea... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112600
BindingDB Entry DOI: 10.7270/Q2DR3059 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490834
(CHEMBL2349290)Show SMILES [O-][N+](=O)c1ccc(CSc2nc(SCc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c3ccccc3n2)cc1 Show InChI InChI=1S/C29H21N7O2S2/c37-36(38)22-15-11-20(12-16-22)18-40-29-30-26-8-4-3-7-25(26)28(31-29)39-17-19-9-13-21(14-10-19)23-5-1-2-6-24(23)27-32-34-35-33-27/h1-16H,17-18H2,(H,32,33,34,35) | PDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490833
(CHEMBL2349289)Show SMILES Fc1ccc(CSc2nc(SCc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c3ccccc3n2)cc1 Show InChI InChI=1S/C29H21FN6S2/c30-22-15-11-20(12-16-22)18-38-29-31-26-8-4-3-7-25(26)28(32-29)37-17-19-9-13-21(14-10-19)23-5-1-2-6-24(23)27-33-35-36-34-27/h1-16H,17-18H2,(H,33,34,35,36) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490832
(CHEMBL2349288)Show SMILES C(Sc1nc(SCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ccccc2n1)c1ccccc1 Show InChI InChI=1S/C29H22N6S2/c1-2-8-20(9-3-1)19-37-29-30-26-13-7-6-12-25(26)28(31-29)36-18-21-14-16-22(17-15-21)23-10-4-5-11-24(23)27-32-34-35-33-27/h1-17H,18-19H2,(H,32,33,34,35) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490846
(CHEMBL2349294)Show SMILES C(Sc1ncnc2ccccc12)c1ccc(cc1)-c1ccc(cc1)-c1nnn[nH]1 Show InChI InChI=1S/C22H16N6S/c1-2-4-20-19(3-1)22(24-14-23-20)29-13-15-5-7-16(8-6-15)17-9-11-18(12-10-17)21-25-27-28-26-21/h1-12,14H,13H2,(H,25,26,27,28) | PDB
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UniChem
| Article
PubMed
| n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490843
(CHEMBL2349296)Show SMILES Cc1nc(SCc2ccc(cc2)-c2ccc(cc2)-c2nnn[nH]2)c2ccccc2n1 Show InChI InChI=1S/C23H18N6S/c1-15-24-21-5-3-2-4-20(21)23(25-15)30-14-16-6-8-17(9-7-16)18-10-12-19(13-11-18)22-26-28-29-27-22/h2-13H,14H2,1H3,(H,26,27,28,29) | PDB
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UniChem
| Article
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| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490831
(CHEMBL2349293)Show SMILES C(Sc1ncnc2ccccc12)c1ccc(cc1)-c1cccc(c1)-c1nnn[nH]1 Show InChI InChI=1S/C22H16N6S/c1-2-7-20-19(6-1)22(24-14-23-20)29-13-15-8-10-16(11-9-15)17-4-3-5-18(12-17)21-25-27-28-26-21/h1-12,14H,13H2,(H,25,26,27,28) | PDB
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UniChem
| Article
PubMed
| n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM26197
(CHEMBL112 | N-(4-hydroxyphenyl)acetamide | Norco |...)Show InChI InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) | PDB
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Patents
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CYP2D6 (unknown origin) in baculosomes preincubated for 20 mins followed by addition of CYP enzyme-specific substrate and NADP+ and mea... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112600
BindingDB Entry DOI: 10.7270/Q2DR3059 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50555693
(CHEMBL4800229)Show SMILES Oc1ccc(NC(=O)CNS(=O)(=O)c2ccccc2C(=O)NCCc2ccc(O)c(O)c2)cc1 | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CYP2D6 (unknown origin) in baculosomes preincubated for 20 mins followed by addition of CYP enzyme-specific substrate and NADP+ and mea... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112600
BindingDB Entry DOI: 10.7270/Q2DR3059 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50555692
(CHEMBL4800549)Show SMILES CNC(=O)c1ccccc1S(=O)(=O)NCC(=O)Nc1ccc(O)cc1 | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CYP2D6 (unknown origin) in baculosomes preincubated for 20 mins followed by addition of CYP enzyme-specific substrate and NADP+ and mea... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112600
BindingDB Entry DOI: 10.7270/Q2DR3059 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM26197
(CHEMBL112 | N-(4-hydroxyphenyl)acetamide | Norco |...)Show InChI InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) | PDB
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| DrugBank
Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CYP3A4 (unknown origin) in baculosomes preincubated for 20 mins followed by addition of CYP enzyme-specific substrate and NADP+ and mea... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112600
BindingDB Entry DOI: 10.7270/Q2DR3059 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50555692
(CHEMBL4800549)Show SMILES CNC(=O)c1ccccc1S(=O)(=O)NCC(=O)Nc1ccc(O)cc1 | PDB
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UniChem
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PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CYP3A4 (unknown origin) in baculosomes preincubated for 20 mins followed by addition of CYP enzyme-specific substrate and NADP+ and mea... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112600
BindingDB Entry DOI: 10.7270/Q2DR3059 |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50216464
(CHEMBL146048)Show SMILES Cc1nc(SCc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)c2ccccc2n1 Show InChI InChI=1S/C23H18N6S/c1-15-24-21-9-5-4-8-20(21)23(25-15)30-14-16-10-12-17(13-11-16)18-6-2-3-7-19(18)22-26-28-29-27-22/h2-13H,14H2,1H3,(H,26,27,28,29) | PDB
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| CHEMBL
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| Article
PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490830
(CHEMBL2349275)Show SMILES Clc1ccc(cc1)-c1nc(SCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ccccc2n1 Show InChI InChI=1S/C28H19ClN6S/c29-21-15-13-20(14-16-21)26-30-25-8-4-3-7-24(25)28(31-26)36-17-18-9-11-19(12-10-18)22-5-1-2-6-23(22)27-32-34-35-33-27/h1-16H,17H2,(H,32,33,34,35) | PDB
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| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490841
(CHEMBL2349287)Show SMILES COC(=O)c1ccc(cc1)-c1ccc(CSc2nc(nc3ccccc23)C(C)C)cc1 Show InChI InChI=1S/C26H24N2O2S/c1-17(2)24-27-23-7-5-4-6-22(23)25(28-24)31-16-18-8-10-19(11-9-18)20-12-14-21(15-13-20)26(29)30-3/h4-15,17H,16H2,1-3H3 | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 3.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490842
(CHEMBL2349272)Show SMILES CC(C)c1nc(SCc2ccc(cc2)-c2ccccc2C(O)=O)c2ccccc2n1 Show InChI InChI=1S/C25H22N2O2S/c1-16(2)23-26-22-10-6-5-9-21(22)24(27-23)30-15-17-11-13-18(14-12-17)19-7-3-4-8-20(19)25(28)29/h3-14,16H,15H2,1-2H3,(H,28,29) | PDB
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| Article
PubMed
| n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490826
(CHEMBL2349285)Show SMILES COC(=O)c1ccccc1-c1ccc(CSc2nc(nc3ccccc23)C(C)C)cc1 Show InChI InChI=1S/C26H24N2O2S/c1-17(2)24-27-23-11-7-6-10-22(23)25(28-24)31-16-18-12-14-19(15-13-18)20-8-4-5-9-21(20)26(29)30-3/h4-15,17H,16H2,1-3H3 | PDB
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UniChem
| Article
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490838
(CHEMBL2349278)Show InChI InChI=1S/C22H15N3S/c23-13-18-5-1-2-6-19(18)17-11-9-16(10-12-17)14-26-22-20-7-3-4-8-21(20)24-15-25-22/h1-12,15H,14H2 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490840
(CHEMBL2349283)Show SMILES Fc1ccc(CSc2nc(SCc3ccc(cc3)-c3ccccc3C#N)c3ccccc3n2)cc1 Show InChI InChI=1S/C29H20FN3S2/c30-24-15-11-21(12-16-24)19-35-29-32-27-8-4-3-7-26(27)28(33-29)34-18-20-9-13-22(14-10-20)25-6-2-1-5-23(25)17-31/h1-16H,18-19H2 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490837
(CHEMBL2349286)Show SMILES COC(=O)c1cccc(c1)-c1ccc(CSc2nc(nc3ccccc23)C(C)C)cc1 Show InChI InChI=1S/C26H24N2O2S/c1-17(2)24-27-23-10-5-4-9-22(23)25(28-24)31-16-18-11-13-19(14-12-18)20-7-6-8-21(15-20)26(29)30-3/h4-15,17H,16H2,1-3H3 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490827
(CHEMBL2349284)Show SMILES [O-][N+](=O)c1ccc(CSc2nc(SCc3ccc(cc3)-c3ccccc3C#N)c3ccccc3n2)cc1 Show InChI InChI=1S/C29H20N4O2S2/c30-17-23-5-1-2-6-25(23)22-13-9-20(10-14-22)18-36-28-26-7-3-4-8-27(26)31-29(32-28)37-19-21-11-15-24(16-12-21)33(34)35/h1-16H,18-19H2 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490829
(CHEMBL2349276)Show SMILES Brc1cc(Br)c2c(SCc3ccc(cc3)-c3cccc(c3)-c3nnn[nH]3)nc(CCc3ccccc3)nc2c1 Show InChI InChI=1S/C30H22Br2N6S/c31-24-16-25(32)28-26(17-24)33-27(14-11-19-5-2-1-3-6-19)34-30(28)39-18-20-9-12-21(13-10-20)22-7-4-8-23(15-22)29-35-37-38-36-29/h1-10,12-13,15-17H,11,14,18H2,(H,35,36,37,38) | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490847
(CHEMBL2349279)Show InChI InChI=1S/C23H17N3S/c1-16-25-22-9-5-4-8-21(22)23(26-16)27-15-17-10-12-18(13-11-17)20-7-3-2-6-19(20)14-24/h2-13H,15H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490850
(CHEMBL2349281)Show SMILES CC(C)c1nc(SCc2ccc(cc2)-c2ccccc2C#N)c2ccccc2n1 Show InChI InChI=1S/C25H21N3S/c1-17(2)24-27-23-10-6-5-9-22(23)25(28-24)29-16-18-11-13-19(14-12-18)21-8-4-3-7-20(21)15-26/h3-14,17H,16H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B
(Homo sapiens (Human)) | BDBM50490828
(CHEMBL2349280)Show SMILES ClC(Cl)(Cl)c1nc(SCc2ccc(cc2)-c2ccccc2C#N)c2ccccc2n1 Show InChI InChI=1S/C23H14Cl3N3S/c24-23(25,26)22-28-20-8-4-3-7-19(20)21(29-22)30-14-15-9-11-16(12-10-15)18-6-2-1-5-17(18)13-27/h1-12H,14H2 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad de Alcala
Curated by ChEMBL
| Assay Description
Inhibition of PDE7 catalytic domain (unknown origin) using [3H]-cAMP as substrate after 1 hr by scintillation proximity assay |
Bioorg Med Chem 21: 2370-2378 (2013)
Article DOI: 10.1016/j.bmc.2013.01.067
BindingDB Entry DOI: 10.7270/Q2QR512X |
More data for this
Ligand-Target Pair | |
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