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Compile Data Set for Download or QSAR

Found 41 hits with Last Name = 'ambartsumova' and Initial = 'r'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50231755
PNG
(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Show SMILES CC1(C)CCc2nc(ccc2C1=O)C#Cc1ccccc1
Show InChI InChI=1S/C19H17NO/c1-19(2)13-12-17-16(18(19)21)11-10-15(20-17)9-8-14-6-4-3-5-7-14/h3-7,10-11H,12-13H2,1-2H3
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n/an/a 23n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438277
PNG
(CHEMBL2408412)
Show SMILES CC1CC(=O)c2cc(cnc2C1)C#Cc1ccccc1
Show InChI InChI=1S/C18H15NO/c1-13-9-17-16(18(20)10-13)11-15(12-19-17)8-7-14-5-3-2-4-6-14/h2-6,11-13H,9-10H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438295
PNG
(CHEMBL2408568)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(Cl)cc3)nc2C1
Show InChI InChI=1S/C15H14ClN3O/c1-9-6-13-12(14(20)7-9)8-17-15(19-13)18-11-4-2-10(16)3-5-11/h2-5,8-9H,6-7H2,1H3,(H,17,18,19)
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n/an/a 34n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438289
PNG
(CHEMBL2408574)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(Cl)nc3)nc2C1
Show InChI InChI=1S/C14H13ClN4O/c1-8-4-11-10(12(20)5-8)7-17-14(19-11)18-9-2-3-13(15)16-6-9/h2-3,6-8H,4-5H2,1H3,(H,17,18,19)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438278
PNG
(CHEMBL2408411)
Show SMILES CC1(C)CC(=O)c2cc(cnc2C1)C#Cc1ccccc1
Show InChI InChI=1S/C19H17NO/c1-19(2)11-17-16(18(21)12-19)10-15(13-20-17)9-8-14-6-4-3-5-7-14/h3-7,10,13H,11-12H2,1-2H3
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438294
PNG
(CHEMBL2408569)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(cc3)C#N)nc2C1
Show InChI InChI=1S/C16H14N4O/c1-10-6-14-13(15(21)7-10)9-18-16(20-14)19-12-4-2-11(8-17)3-5-12/h2-5,9-10H,6-7H2,1H3,(H,18,19,20)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438298
PNG
(CHEMBL2408565)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C)cc3)nc2C1
Show InChI InChI=1S/C16H17N3O/c1-10-3-5-12(6-4-10)18-16-17-9-13-14(19-16)7-11(2)8-15(13)20/h3-6,9,11H,7-8H2,1-2H3,(H,17,18,19)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438288
PNG
(CHEMBL2408575)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C)nc3)nc2C1
Show InChI InChI=1S/C15H16N4O/c1-9-5-13-12(14(20)6-9)8-17-15(19-13)18-11-4-3-10(2)16-7-11/h3-4,7-9H,5-6H2,1-2H3,(H,17,18,19)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438305
PNG
(CHEMBL2408585)
Show SMILES Clc1cccc(Nc2ncc3C(=O)CCCc3n2)c1
Show InChI InChI=1S/C14H12ClN3O/c15-9-3-1-4-10(7-9)17-14-16-8-11-12(18-14)5-2-6-13(11)19/h1,3-4,7-8H,2,5-6H2,(H,16,17,18)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438291
PNG
(CHEMBL2408572)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(OC(F)F)cc3)nc2C1
Show InChI InChI=1S/C16H15F2N3O2/c1-9-6-13-12(14(22)7-9)8-19-16(21-13)20-10-2-4-11(5-3-10)23-15(17)18/h2-5,8-9,15H,6-7H2,1H3,(H,19,20,21)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438293
PNG
(CHEMBL2408570)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C#N)c(F)c3)nc2C1
Show InChI InChI=1S/C16H13FN4O/c1-9-4-14-12(15(22)5-9)8-19-16(21-14)20-11-3-2-10(7-18)13(17)6-11/h2-3,6,8-9H,4-5H2,1H3,(H,19,20,21)
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n/an/a 157n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438298
PNG
(CHEMBL2408565)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C)cc3)nc2C1
Show InChI InChI=1S/C16H17N3O/c1-10-3-5-12(6-4-10)18-16-17-9-13-14(19-16)7-11(2)8-15(13)20/h3-6,9,11H,7-8H2,1-2H3,(H,17,18,19)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438298
PNG
(CHEMBL2408565)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C)cc3)nc2C1
Show InChI InChI=1S/C16H17N3O/c1-10-3-5-12(6-4-10)18-16-17-9-13-14(19-16)7-11(2)8-15(13)20/h3-6,9,11H,7-8H2,1-2H3,(H,17,18,19)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438300
PNG
(CHEMBL2408563)
Show SMILES CC1(C)CC(=O)c2cnc(Nc3ccc(Cl)cc3)nc2C1
Show InChI InChI=1S/C16H16ClN3O/c1-16(2)7-13-12(14(21)8-16)9-18-15(20-13)19-11-5-3-10(17)4-6-11/h3-6,9H,7-8H2,1-2H3,(H,18,19,20)
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n/an/a 245n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438303
PNG
(CHEMBL2408561)
Show SMILES O=C1CCCc2nc(Nc3cccc(c3)C#N)ncc12
Show InChI InChI=1S/C15H12N4O/c16-8-10-3-1-4-11(7-10)18-15-17-9-12-13(19-15)5-2-6-14(12)20/h1,3-4,7,9H,2,5-6H2,(H,17,18,19)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438281
PNG
(CHEMBL2408408)
Show SMILES Clc1cccc(Nc2ncc3CCCCc3n2)c1
Show InChI InChI=1S/C14H14ClN3/c15-11-5-3-6-12(8-11)17-14-16-9-10-4-1-2-7-13(10)18-14/h3,5-6,8-9H,1-2,4,7H2,(H,16,17,18)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438301
PNG
(CHEMBL1389853)
Show SMILES Cc1ccc(Nc2ncc3C(=O)CC(C)(C)Cc3n2)cc1
Show InChI InChI=1S/C17H19N3O/c1-11-4-6-12(7-5-11)19-16-18-10-13-14(20-16)8-17(2,3)9-15(13)21/h4-7,10H,8-9H2,1-3H3,(H,18,19,20)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438299
PNG
(CHEMBL2408564)
Show SMILES CC1(C)CC(=O)c2cnc(Nc3ccc(cc3)C#N)nc2C1
Show InChI InChI=1S/C17H16N4O/c1-17(2)7-14-13(15(22)8-17)10-19-16(21-14)20-12-5-3-11(9-18)4-6-12/h3-6,10H,7-8H2,1-2H3,(H,19,20,21)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438309
PNG
(CHEMBL2408582)
Show SMILES Cc1cccc(Nc2ncc3C(=O)CCCc3n2)c1
Show InChI InChI=1S/C15H15N3O/c1-10-4-2-5-11(8-10)17-15-16-9-12-13(18-15)6-3-7-14(12)19/h2,4-5,8-9H,3,6-7H2,1H3,(H,16,17,18)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438292
PNG
(CHEMBL2408571)
Show SMILES COc1ccc(Nc2ncc3C(=O)CC(C)Cc3n2)cc1
Show InChI InChI=1S/C16H17N3O2/c1-10-7-14-13(15(20)8-10)9-17-16(19-14)18-11-3-5-12(21-2)6-4-11/h3-6,9-10H,7-8H2,1-2H3,(H,17,18,19)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438290
PNG
(CHEMBL2408573)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(Cl)cn3)nc2C1
Show InChI InChI=1S/C14H13ClN4O/c1-8-4-11-10(12(20)5-8)7-17-14(18-11)19-13-3-2-9(15)6-16-13/h2-3,6-8H,4-5H2,1H3,(H,16,17,18,19)
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n/an/a 721n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438304
PNG
(CHEMBL2408413)
Show SMILES Clc1ccc(Nc2ncc3C(=O)CCCc3n2)cc1
Show InChI InChI=1S/C14H12ClN3O/c15-9-4-6-10(7-5-9)17-14-16-8-11-12(18-14)2-1-3-13(11)19/h4-8H,1-3H2,(H,16,17,18)
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n/an/a 722n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438283
PNG
(CHEMBL2408406)
Show SMILES Cc1cccc(Nc2ncc3C(=O)CCC(C)(C)c3n2)c1
Show InChI InChI=1S/C17H19N3O/c1-11-5-4-6-12(9-11)19-16-18-10-13-14(21)7-8-17(2,3)15(13)20-16/h4-6,9-10H,7-8H2,1-3H3,(H,18,19,20)
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n/an/a 1.04E+3n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438286
PNG
(CHEMBL2408577)
Show SMILES CCC1CC(=O)c2cnc(Nc3ccc(Cl)cc3)nc2C1
Show InChI InChI=1S/C16H16ClN3O/c1-2-10-7-14-13(15(21)8-10)9-18-16(20-14)19-12-5-3-11(17)4-6-12/h3-6,9-10H,2,7-8H2,1H3,(H,18,19,20)
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n/an/a 1.12E+3n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438287
PNG
(CHEMBL2408576)
Show SMILES C[C@H]1CC[C@@H](CC1)Nc1ncc2C(=O)CC(C)Cc2n1 |r,wU:4.7,wD:1.0,(19.82,-24.85,;18.48,-25.61,;17.15,-24.84,;15.81,-25.61,;15.81,-27.15,;17.15,-27.92,;18.47,-27.16,;14.48,-27.92,;13.15,-27.15,;13.14,-25.61,;11.81,-24.85,;10.49,-25.61,;9.16,-24.84,;9.16,-23.3,;7.83,-25.61,;7.83,-27.15,;6.5,-27.93,;9.16,-27.92,;10.49,-27.15,;11.82,-27.92,)|
Show InChI InChI=1S/C16H23N3O/c1-10-3-5-12(6-4-10)18-16-17-9-13-14(19-16)7-11(2)8-15(13)20/h9-12H,3-8H2,1-2H3,(H,17,18,19)/t10-,11?,12-
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n/an/a 1.13E+3n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438307
PNG
(CHEMBL2408583)
Show SMILES Fc1cccc(Nc2ncc3C(=O)CCCc3n2)c1
Show InChI InChI=1S/C14H12FN3O/c15-9-3-1-4-10(7-9)17-14-16-8-11-12(18-14)5-2-6-13(11)19/h1,3-4,7-8H,2,5-6H2,(H,16,17,18)
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n/an/a 2.23E+3n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438310
PNG
(CHEMBL2408581)
Show SMILES Fc1ccc(Nc2nc3CCCCc3s2)cc1
Show InChI InChI=1S/C13H13FN2S/c14-9-5-7-10(8-6-9)15-13-16-11-3-1-2-4-12(11)17-13/h5-8H,1-4H2,(H,15,16)
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n/an/a 2.57E+3n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438280
PNG
(CHEMBL2408409)
Show SMILES Clc1ccc(Nc2ncc3CCCCc3n2)cc1
Show InChI InChI=1S/C14H14ClN3/c15-11-5-7-12(8-6-11)17-14-16-9-10-3-1-2-4-13(10)18-14/h5-9H,1-4H2,(H,16,17,18)
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n/an/a 4.71E+3n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438296
PNG
(CHEMBL2408567)
Show SMILES CC1CC(=O)c2cnc(Nc3cccc(Cl)c3)nc2C1
Show InChI InChI=1S/C15H14ClN3O/c1-9-5-13-12(14(20)6-9)8-17-15(19-13)18-11-4-2-3-10(16)7-11/h2-4,7-9H,5-6H2,1H3,(H,17,18,19)
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n/an/a 6.16E+3n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438302
PNG
(CHEMBL2408562)
Show SMILES Fc1cc(Nc2ncc3C(=O)CCCc3n2)cc(c1)C#N
Show InChI InChI=1S/C15H11FN4O/c16-10-4-9(7-17)5-11(6-10)19-15-18-8-12-13(20-15)2-1-3-14(12)21/h4-6,8H,1-3H2,(H,18,19,20)
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n/an/a 1.10E+4n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))		BDBM50438310
PNG
(CHEMBL2408581)
Show SMILES Fc1ccc(Nc2nc3CCCCc3s2)cc1
Show InChI InChI=1S/C13H13FN2S/c14-9-5-7-10(8-6-9)15-13-16-11-3-1-2-4-12(11)17-13/h5-8H,1-4H2,(H,15,16)
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n/an/a 6.40E+4n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR1 expressed in CHO cells assessed as inhibition of L-glutamate-induced intracellular cAMP accumulation t...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438306
PNG
(CHEMBL2408584)
Show SMILES Clc1ccccc1Nc1ncc2C(=O)CCCc2n1
Show InChI InChI=1S/C14H12ClN3O/c15-10-4-1-2-5-12(10)18-14-16-8-9-11(17-14)6-3-7-13(9)19/h1-2,4-5,8H,3,6-7H2,(H,16,17,18)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438285
PNG
(CHEMBL2408578)
Show SMILES CCCC1CC(=O)c2cnc(Nc3ccc(Cl)cc3)nc2C1
Show InChI InChI=1S/C17H18ClN3O/c1-2-3-11-8-15-14(16(22)9-11)10-19-17(21-15)20-13-6-4-12(18)5-7-13/h4-7,10-11H,2-3,8-9H2,1H3,(H,19,20,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438284
PNG
(CHEMBL2408580)
Show SMILES Cc1ccc(Nc2ncc3C(=O)C(C)(C)CCc3n2)cc1
Show InChI InChI=1S/C17H19N3O/c1-11-4-6-12(7-5-11)19-16-18-10-13-14(20-16)8-9-17(2,3)15(13)21/h4-7,10H,8-9H2,1-3H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438282
PNG
(CHEMBL2408407)
Show SMILES Cc1ccc(Nc2ncc3C(=O)CCC(C)(C)c3n2)cc1
Show InChI InChI=1S/C17H19N3O/c1-11-4-6-12(7-5-11)19-16-18-10-13-14(21)8-9-17(2,3)15(13)20-16/h4-7,10H,8-9H2,1-3H3,(H,18,19,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438297
PNG
(CHEMBL2408566)
Show SMILES CC1CC(=O)c2cnc(Nc3ccccc3Cl)nc2C1
Show InChI InChI=1S/C15H14ClN3O/c1-9-6-13-10(14(20)7-9)8-17-15(19-13)18-12-5-3-2-4-11(12)16/h2-5,8-9H,6-7H2,1H3,(H,17,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(Homo sapiens (Human))		BDBM50438309
PNG
(CHEMBL2408582)
Show SMILES Cc1cccc(Nc2ncc3C(=O)CCCc3n2)c1
Show InChI InChI=1S/C15H15N3O/c1-10-4-2-5-11(8-10)17-15-16-9-12-13(18-15)6-3-7-14(12)19/h2,4-5,8-9H,3,6-7H2,1H3,(H,16,17,18)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR1 expressed in CHO cells assessed as inhibition of L-glutamate-induced intracellular cAMP accumulation t...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438308
PNG
(CHEMBL1438160)
Show SMILES Cc1cc(C)cc(Nc2ncc3C(=O)CCCc3n2)c1
Show InChI InChI=1S/C16H17N3O/c1-10-6-11(2)8-12(7-10)18-16-17-9-13-14(19-16)4-3-5-15(13)20/h6-9H,3-5H2,1-2H3,(H,17,18,19)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438276
PNG
(CHEMBL2408579)
Show SMILES Cc1cccc(Nc2ncc3C(=O)C(C)(C)CCc3n2)c1
Show InChI InChI=1S/C17H19N3O/c1-11-5-4-6-12(9-11)19-16-18-10-13-14(20-16)7-8-17(2,3)15(13)21/h4-6,9-10H,7-8H2,1-3H3,(H,18,19,20)
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n/an/an/an/a 694n/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR5 expressed in CHO cells assessed as increase of L-quisqualate-induced intracellular cAMP accumulation t...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50231741
PNG
(2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...)
Show SMILES O=C1CCCc2nc(ccc12)C#Cc1ccccc1
Show InChI InChI=1S/C17H13NO/c19-17-8-4-7-16-15(17)12-11-14(18-16)10-9-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-8H2
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n/an/an/an/a 50n/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438279
PNG
(CHEMBL2408410)
Show SMILES O=C1CCCc2ncc(cc12)C#Cc1ccccc1
Show InChI InChI=1S/C17H13NO/c19-17-8-4-7-16-15(17)11-14(12-18-16)10-9-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-8H2
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n/an/an/an/a 31n/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair