Found 14 hits with Last Name = 'andré' and Initial = 'ac' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50404744
(CHEMBL19047)Show SMILES BrCCOc1cc(OCCBr)c2c(c1)oc(-c1ccc(OCCBr)c(OCCBr)c1)c(OCCBr)c2=O Show InChI InChI=1S/C25H25Br5O7/c26-3-8-32-17-14-20(35-11-6-29)22-21(15-17)37-24(25(23(22)31)36-12-7-30)16-1-2-18(33-9-4-27)19(13-16)34-10-5-28/h1-2,13-15H,3-12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50404740
(CHEMBL436338)Show SMILES CCOc1cc(OCC(O)=O)c2c(c1)oc(-c1ccc(OCC)c(OCC)c1)c(OCC)c2=O Show InChI InChI=1S/C25H28O9/c1-5-29-16-12-19(33-14-21(26)27)22-20(13-16)34-24(25(23(22)28)32-8-4)15-9-10-17(30-6-2)18(11-15)31-7-3/h9-13H,5-8,14H2,1-4H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50404743
(CHEMBL273765)Show SMILES CCOc1cc(OCC)c2c(c1)oc(-c1ccc(OCC)c(OCC)c1)c(OCC(O)=O)c2=O Show InChI InChI=1S/C25H28O9/c1-5-29-16-12-19(32-8-4)22-20(13-16)34-24(25(23(22)28)33-14-21(26)27)15-9-10-17(30-6-2)18(11-15)31-7-3/h9-13H,5-8,14H2,1-4H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 7.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50404745
(CHEMBL18262)Show SMILES CCOc1cc(OCCN(CC)CC)c2c(c1)oc(-c1ccc(OCC)c(OCC)c1)c(OCC)c2=O Show InChI InChI=1S/C29H39NO7/c1-7-30(8-2)15-16-36-24-18-21(32-9-3)19-25-26(24)27(31)29(35-12-6)28(37-25)20-13-14-22(33-10-4)23(17-20)34-11-5/h13-14,17-19H,7-12,15-16H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM7460
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 8.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50404748
(CHEMBL19032 | NSC-115922)Show SMILES COc1cc(OC)c2c(c1)oc(-c1ccc(OC)c(OC)c1)c(OC)c2=O Show InChI InChI=1S/C20H20O7/c1-22-12-9-15(25-4)17-16(10-12)27-19(20(26-5)18(17)21)11-6-7-13(23-2)14(8-11)24-3/h6-10H,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 9.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50404739
(CHEMBL276918)Show SMILES CCOc1cc(OCCBr)c2c(c1)oc(-c1ccc(OCC)c(OCC)c1)c(OCC)c2=O Show InChI InChI=1S/C25H29BrO7/c1-5-28-17-14-20(32-12-11-26)22-21(15-17)33-24(25(23(22)27)31-8-4)16-9-10-18(29-6-2)19(13-16)30-7-3/h9-10,13-15H,5-8,11-12H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 9.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50404741
(CHEMBL278972)Show SMILES CCOc1cc(OCC)c2c(c1)oc(-c1ccc(OCC)c(OCC)c1)c(OCCN(CC)CC)c2=O Show InChI InChI=1S/C29H39NO7/c1-7-30(8-2)15-16-36-29-27(31)26-24(35-12-6)18-21(32-9-3)19-25(26)37-28(29)20-13-14-22(33-10-4)23(17-20)34-11-5/h13-14,17-19H,7-12,15-16H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.26E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50404746
(NSC-115919 | PENTAACETYLQUERCETIN)Show SMILES CC(=O)Oc1cc(OC(C)=O)c2c(c1)oc(-c1ccc(OC(C)=O)c(OC(C)=O)c1)c(OC(C)=O)c2=O Show InChI InChI=1S/C25H20O12/c1-11(26)32-17-9-20(35-14(4)29)22-21(10-17)37-24(25(23(22)31)36-15(5)30)16-6-7-18(33-12(2)27)19(8-16)34-13(3)28/h6-10H,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.75E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50404742
(CHEMBL18487)Show SMILES CCOc1cc(OCC)c2c(c1)oc(-c1ccc(OCC)c(OCC)c1)c(OCC)c2=O Show InChI InChI=1S/C25H30O7/c1-6-27-17-14-20(30-9-4)22-21(15-17)32-24(25(23(22)26)31-10-5)16-11-12-18(28-7-2)19(13-16)29-8-3/h11-15H,6-10H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.50E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50404747
(CHEMBL18415)Show SMILES CCOC(=O)COc1cc(OCC)cc2oc(-c3ccc(OCC)c(OCC)c3)c(OCC)c(=O)c12 Show InChI InChI=1S/C27H32O9/c1-6-30-18-14-21(35-16-23(28)33-9-4)24-22(15-18)36-26(27(25(24)29)34-10-5)17-11-12-19(31-7-2)20(13-17)32-8-3/h11-15H,6-10,16H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 7.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50010981
((Ro 20-1724)4-(3-Butoxy-4-methoxy-benzyl)-imidazol...)Show InChI InChI=1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM50404738
(CHEMBL18609)Show SMILES OCCOc1cc(OCCO)c2c(c1)oc(-c1ccc(OCCO)c(OCCO)c1)c(OCCO)c2=O Show InChI InChI=1S/C25H30O12/c26-3-8-32-17-14-20(35-11-6-29)22-21(15-17)37-24(25(23(22)31)36-12-7-30)16-1-2-18(33-9-4-27)19(13-16)34-10-5-28/h1-2,13-15,26-30H,3-12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this
Ligand-Target Pair | |
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