Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] (Rattus norvegicus (rat)) | BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 127 | n/a | n/a | n/a | n/a | 8.0 | 30 |
University of Copenhagen | Assay Description To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and... | Protein Sci 13: 1031-42 (2004) Article DOI: 10.1110/ps.03533004 BindingDB Entry DOI: 10.7270/Q2FB5163 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rattus norvegicus (rat)) | BDBM15339 (6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-qui...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 367 | n/a | n/a | n/a | n/a | 8.0 | 30 |
University of Copenhagen | Assay Description To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and... | Protein Sci 13: 1031-42 (2004) Article DOI: 10.1110/ps.03533004 BindingDB Entry DOI: 10.7270/Q2FB5163 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial (Rattus norvegicus (rat)) | BDBM16301 (3-[4-(4-chlorophenyl)cyclohexyl]naphthalene-1,2,4-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 698 | n/a | n/a | n/a | n/a | 8.0 | 30 |
University of Copenhagen | Assay Description To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and... | Protein Sci 13: 1031-42 (2004) Article DOI: 10.1110/ps.03533004 BindingDB Entry DOI: 10.7270/Q2FB5163 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] (Rattus norvegicus (rat)) | BDBM16301 (3-[4-(4-chlorophenyl)cyclohexyl]naphthalene-1,2,4-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 904 | n/a | n/a | n/a | n/a | 8.0 | 30 |
University of Copenhagen | Assay Description To determine the inhibitory potency of the drugs, the initial velocity of the DHODR-catalyzed reaction at saturating concentrations of DHO (1 mM) and... | Protein Sci 13: 1031-42 (2004) Article DOI: 10.1110/ps.03533004 BindingDB Entry DOI: 10.7270/Q2FB5163 | |||||||||||
More data for this Ligand-Target Pair |