Found 51 hits with Last Name = 'arcari' and Initial = 'jt' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50414549
(CHEMBL563480)Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)-c1c(Cl)cccc1Cl Show InChI InChI=1S/C19H16Cl2N4O2S/c1-2-25-8-9-27-15-7-6-11(10-14(15)25)17(26)22-19-24-23-18(28-19)16-12(20)4-3-5-13(16)21/h3-7,10H,2,8-9H2,1H3,(H,22,24,26) | PDB
KEGG
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GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166587
(CHEMBL3799530)Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CCN(CC1)C(=O)C(C)(C)O Show InChI InChI=1S/C22H27FN6O3S/c1-5-29-16-11-13(10-15(23)14(16)12-24-29)17(30)25-20-27-26-18(33-20)22(4)6-8-28(9-7-22)19(31)21(2,3)32/h10-12,32H,5-9H2,1-4H3,(H,25,27,30) | PDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166584
(CHEMBL3797819)Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CCN(CC1)C(C)=O Show InChI InChI=1S/C20H23FN6O2S/c1-4-27-16-10-13(9-15(21)14(16)11-22-27)17(29)23-19-25-24-18(30-19)20(3)5-7-26(8-6-20)12(2)28/h9-11H,4-8H2,1-3H3,(H,23,25,29) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166580
(CHEMBL3797824)Show InChI InChI=1S/C15H14ClN5OS/c1-2-21-12-6-9(5-11(16)10(12)7-17-21)13(22)18-15-20-19-14(23-15)8-3-4-8/h5-8H,2-4H2,1H3,(H,18,20,22) | PDB
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UniChem
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166585
(CHEMBL3798872)Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CCN(CC1)C(=O)CO Show InChI InChI=1S/C20H23FN6O3S/c1-3-27-15-9-12(8-14(21)13(15)10-22-27)17(30)23-19-25-24-18(31-19)20(2)4-6-26(7-5-20)16(29)11-28/h8-10,28H,3-7,11H2,1-2H3,(H,23,25,30) | PDB
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166586
(CHEMBL3799118)Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CCN(CC1)C(=O)C(C)O Show InChI InChI=1S/C21H25FN6O3S/c1-4-28-16-10-13(9-15(22)14(16)11-23-28)17(30)24-20-26-25-19(32-20)21(3)5-7-27(8-6-21)18(31)12(2)29/h9-12,29H,4-8H2,1-3H3,(H,24,26,30) | PDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166581
(CHEMBL3797387)Show InChI InChI=1S/C15H14FN5OS/c1-2-21-12-6-9(5-11(16)10(12)7-17-21)13(22)18-15-20-19-14(23-15)8-3-4-8/h5-8H,2-4H2,1H3,(H,18,20,22) | PDB
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166583
(CHEMBL3797483)Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CCN(C1)C(C)=O Show InChI InChI=1S/C19H21FN6O2S/c1-4-26-15-8-12(7-14(20)13(15)9-21-26)16(28)22-18-24-23-17(29-18)19(3)5-6-25(10-19)11(2)27/h7-9H,4-6,10H2,1-3H3,(H,22,24,28) | PDB
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| Article
PubMed
| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166582
(CHEMBL3798781)Show SMILES CCn1ncc2c(F)cc(cc12)C(=O)Nc1nnc(s1)C1(C)CN(C1)C(C)=O Show InChI InChI=1S/C18H19FN6O2S/c1-4-25-14-6-11(5-13(19)12(14)7-20-25)15(27)21-17-23-22-16(28-17)18(3)8-24(9-18)10(2)26/h5-7H,4,8-9H2,1-3H3,(H,21,23,27) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166574
(CHEMBL3798598)Show InChI InChI=1S/C16H18N4O2S/c1-2-20-7-8-22-13-6-5-11(9-12(13)20)14(21)17-16-19-18-15(23-16)10-3-4-10/h5-6,9-10H,2-4,7-8H2,1H3,(H,17,19,21) | PDB
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| Article
PubMed
| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | Reactome pathway
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| Article
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| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human norepinephrine transporter |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166577
(CHEMBL3797362)Show InChI InChI=1S/C15H15N5OS/c1-2-20-12-7-10(5-6-11(12)8-16-20)13(21)17-15-19-18-14(22-15)9-3-4-9/h5-9H,2-4H2,1H3,(H,17,19,21) | PDB
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| Article
PubMed
| 310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166578
(CHEMBL3799153)Show InChI InChI=1S/C16H17N5OS/c1-9(2)21-13-7-11(5-6-12(13)8-17-21)14(22)18-16-20-19-15(23-16)10-3-4-10/h5-10H,3-4H2,1-2H3,(H,18,20,22) | PDB
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| CHEMBL
PC cid
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UniChem
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| Article
PubMed
| 584 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166575
(CHEMBL3798145)Show InChI InChI=1S/C14H13N5OS/c1-19-11-6-9(4-5-10(11)7-15-19)12(20)16-14-18-17-13(21-14)8-2-3-8/h4-8H,2-3H2,1H3,(H,16,18,20) | PDB
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Similars
| Article
PubMed
| 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Macrophage metalloelastase
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
MMDB
Reactome pathway
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CHEMBL
MCE
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UniChem
Similars
| Article
PubMed
| 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP12 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166576
(CHEMBL3799257)Show InChI InChI=1S/C14H13N5OS/c1-19-11-5-4-9(6-10(11)7-15-19)12(20)16-14-18-17-13(21-14)8-2-3-8/h4-8H,2-3H2,1H3,(H,16,18,20) | PDB
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PubMed
| 5.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
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CHEMBL
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UniChem
Similars
| Article
PubMed
| 7.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP13 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166579
(CHEMBL3797257)Show InChI InChI=1S/C13H12N6OS/c1-19-10-4-8(5-14-9(10)6-15-19)11(20)16-13-18-17-12(21-13)7-2-3-7/h4-7H,2-3H2,1H3,(H,16,18,20) | PDB
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UniChem
Similars
| Article
PubMed
| >9.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP3 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Stromelysin-2
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
MMDB
Reactome pathway
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CHEMBL
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Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP10 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Neutrophil collagenase
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
MMDB
Reactome pathway
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CHEMBL
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UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP8 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50414549
(CHEMBL563480)Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)-c1c(Cl)cccc1Cl Show InChI InChI=1S/C19H16Cl2N4O2S/c1-2-25-8-9-27-15-7-6-11(10-14(15)25)17(26)22-19-24-23-18(28-19)16-12(20)4-3-5-13(16)21/h3-7,10H,2,8-9H2,1H3,(H,22,24,26) | PDB
Reactome pathway
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PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human)) | BDBM50166574
(CHEMBL3798598)Show InChI InChI=1S/C16H18N4O2S/c1-2-20-7-8-22-13-6-5-11(9-12(13)20)14(21)17-16-19-18-15(23-16)10-3-4-10/h5-6,9-10H,2-4,7-8H2,1H3,(H,17,19,21) | PDB
Reactome pathway
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PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP4 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50414549
(CHEMBL563480)Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)-c1c(Cl)cccc1Cl Show InChI InChI=1S/C19H16Cl2N4O2S/c1-2-25-8-9-27-15-7-6-11(10-14(15)25)17(26)22-19-24-23-18(28-19)16-12(20)4-3-5-13(16)21/h3-7,10H,2,8-9H2,1H3,(H,22,24,26) | PDB
Reactome pathway
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| CHEMBL
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PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human)) | BDBM50166574
(CHEMBL3798598)Show InChI InChI=1S/C16H18N4O2S/c1-2-20-7-8-22-13-6-5-11(9-12(13)20)14(21)17-16-19-18-15(23-16)10-3-4-10/h5-6,9-10H,2-4,7-8H2,1H3,(H,17,19,21) | PDB
Reactome pathway
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PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50414549
(CHEMBL563480)Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)-c1c(Cl)cccc1Cl Show InChI InChI=1S/C19H16Cl2N4O2S/c1-2-25-8-9-27-15-7-6-11(10-14(15)25)17(26)22-19-24-23-18(28-19)16-12(20)4-3-5-13(16)21/h3-7,10H,2,8-9H2,1H3,(H,22,24,26) | KEGG
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| CHEMBL
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PC sid
UniChem
Similars
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PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP1 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human)) | BDBM50166574
(CHEMBL3798598)Show InChI InChI=1S/C16H18N4O2S/c1-2-20-7-8-22-13-6-5-11(9-12(13)20)14(21)17-16-19-18-15(23-16)10-3-4-10/h5-6,9-10H,2-4,7-8H2,1H3,(H,17,19,21) | KEGG
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| CHEMBL
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PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human recombinant EP1 receptor expressed in human Chem1 cell membrane by scintillation proximity assay |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-25
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | Reactome pathway
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP25 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-26
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | KEGG
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP26 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Disintegrin and metalloproteinase domain-containing protein 17
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
MMDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human TACE |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
MMDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP1 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-24
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
MMDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP24 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP3 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Matrilysin
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP7 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP9 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-14
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP14 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP2 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-20
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP20 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-15
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | Reactome pathway
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP15 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Matrix metalloproteinase-16
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | PDB
MMDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human MMP16 |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50414549
(CHEMBL563480)Show SMILES CCN1CCOc2ccc(cc12)C(=O)Nc1nnc(s1)-c1c(Cl)cccc1Cl Show InChI InChI=1S/C19H16Cl2N4O2S/c1-2-25-8-9-27-15-7-6-11(10-14(15)25)17(26)22-19-24-23-18(28-19)16-12(20)4-3-5-13(16)21/h3-7,10H,2,8-9H2,1H3,(H,22,24,26) | PDB
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| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant EP3 receptor expressed in CHOK1 cells assessed as inhibition of sulprostone-induced decrease in cAMP level p... |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166580
(CHEMBL3797824)Show InChI InChI=1S/C15H14ClN5OS/c1-2-21-12-6-9(5-11(16)10(12)7-17-21)13(22)18-15-20-19-14(23-15)8-3-4-8/h5-8H,2-4H2,1H3,(H,18,20,22) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant EP3 receptor expressed in CHOK1 cells assessed as inhibition of sulprostone-induced decrease in cAMP level p... |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166581
(CHEMBL3797387)Show InChI InChI=1S/C15H14FN5OS/c1-2-21-12-6-9(5-11(16)10(12)7-17-21)13(22)18-15-20-19-14(23-15)8-3-4-8/h5-8H,2-4H2,1H3,(H,18,20,22) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant EP3 receptor expressed in CHOK1 cells assessed as inhibition of sulprostone-induced decrease in cAMP level p... |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166574
(CHEMBL3798598)Show InChI InChI=1S/C16H18N4O2S/c1-2-20-7-8-22-13-6-5-11(9-12(13)20)14(21)17-16-19-18-15(23-16)10-3-4-10/h5-6,9-10H,2-4,7-8H2,1H3,(H,17,19,21) | PDB
KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant EP3 receptor expressed in CHOK1 cells assessed as inhibition of sulprostone-induced decrease in cAMP level p... |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50365344
(CHEMBL1956115)Show SMILES C[C@@](CCc1ccc(cc1)-c1ccccc1)(C(=O)NO)S(C)(=O)=O |r| Show InChI InChI=1S/C18H21NO4S/c1-18(17(20)19-21,24(2,22)23)13-12-14-8-10-16(11-9-14)15-6-4-3-5-7-15/h3-11,21H,12-13H2,1-2H3,(H,19,20)/t18-/m1/s1 | Reactome pathway
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| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human norepinephrine transporter |
J Med Chem 55: 914-23 (2012)
Article DOI: 10.1021/jm2014748
BindingDB Entry DOI: 10.7270/Q2VX0H0W |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166577
(CHEMBL3797362)Show InChI InChI=1S/C15H15N5OS/c1-2-20-12-7-10(5-6-11(12)8-16-20)13(21)17-15-19-18-14(22-15)9-3-4-9/h5-9H,2-4H2,1H3,(H,17,19,21) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 362 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant EP3 receptor expressed in CHOK1 cells assessed as inhibition of sulprostone-induced decrease in cAMP level p... |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50434377
(CHEMBL2387002)Show SMILES CC(C)n1cc(C(=O)c2cccc(NC(=O)Nc3ccc(Cl)cc3)c2)c2c(N)ncnc12 Show InChI InChI=1S/C23H21ClN6O2/c1-13(2)30-11-18(19-21(25)26-12-27-22(19)30)20(31)14-4-3-5-17(10-14)29-23(32)28-16-8-6-15(24)7-9-16/h3-13H,1-2H3,(H2,25,26,27)(H2,28,29,32) | PDB
MMDB
NCI pathway
Reactome pathway
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR (unknown origin) |
Bioorg Med Chem Lett 23: 3059-63 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.012
BindingDB Entry DOI: 10.7270/Q24J0GGF |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166575
(CHEMBL3798145)Show InChI InChI=1S/C14H13N5OS/c1-19-11-6-9(4-5-10(11)7-15-19)12(20)16-14-18-17-13(21-14)8-2-3-8/h4-8H,2-3H2,1H3,(H,16,18,20) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant EP3 receptor expressed in CHOK1 cells assessed as inhibition of sulprostone-induced decrease in cAMP level p... |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166578
(CHEMBL3799153)Show InChI InChI=1S/C16H17N5OS/c1-9(2)21-13-7-11(5-6-12(13)8-17-21)14(22)18-16-20-19-15(23-16)10-3-4-10/h5-10H,3-4H2,1-2H3,(H,18,20,22) | PDB
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant EP3 receptor expressed in CHOK1 cells assessed as inhibition of sulprostone-induced decrease in cAMP level p... |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
Platelet-derived growth factor receptor beta
(Homo sapiens (Human)) | BDBM50434378
(CHEMBL2386994)Show SMILES Nc1ncnc2n(cc(C(=O)c3cccc(NC(=O)Nc4c(F)cccc4F)c3)c12)C1CCCC1 Show InChI InChI=1S/C25H22F2N6O2/c26-18-9-4-10-19(27)21(18)32-25(35)31-15-6-3-5-14(11-15)22(34)17-12-33(16-7-1-2-8-16)24-20(17)23(28)29-13-30-24/h3-6,9-13,16H,1-2,7-8H2,(H2,28,29,30)(H2,31,32,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of PDGFR (unknown origin) |
Bioorg Med Chem Lett 23: 3059-63 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.012
BindingDB Entry DOI: 10.7270/Q24J0GGF |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50166576
(CHEMBL3799257)Show InChI InChI=1S/C14H13N5OS/c1-19-11-5-4-9(6-10(11)7-15-19)12(20)16-14-18-17-13(21-14)8-2-3-8/h4-8H,2-3H2,1H3,(H,16,18,20) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human recombinant EP3 receptor expressed in CHOK1 cells assessed as inhibition of sulprostone-induced decrease in cAMP level p... |
Bioorg Med Chem Lett 26: 2670-5 (2016)
Article DOI: 10.1016/j.bmcl.2016.04.009
BindingDB Entry DOI: 10.7270/Q2CJ8GDR |
More data for this
Ligand-Target Pair | |
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