Found 1383 hits with Last Name = 'bürli' and Initial = 'r' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479267
(US10894789, Compound 66)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccccc1F |r| Show InChI InChI=1S/C23H21F6N5OS/c1-12-7-22(25,26)11-34(17(12)10-32-21-30-8-14(9-31-21)23(27,28)29)20(35)18-19(36-13(2)33-18)15-5-3-4-6-16(15)24/h3-6,8-9,12,17H,7,10-11H2,1-2H3,(H,30,31,32)/t12-,17?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479289
(US10894789, Compound 233)Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)c(C)c1-c1ncccn1 |r| Show InChI InChI=1S/C22H23F5N8O/c1-12-7-21(23,24)11-35(15(12)10-32-20-30-8-14(9-31-20)22(25,26)27)19(36)17-16(13(2)34(3)33-17)18-28-5-4-6-29-18/h4-6,8-9,12,15H,7,10-11H2,1-3H3,(H,30,31,32)/t12-,15-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50264437
(CHEMBL488984 | N-(2-aminopyrimidin-5-yl)-6-chloro-...)Show SMILES Nc1ncc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(c4)C(F)(F)F)noc23)cn1 Show InChI InChI=1S/C19H12ClF3N6O2/c20-13-5-4-12-15(14(13)17(30)28-11-7-25-18(24)26-8-11)31-29-16(12)27-10-3-1-2-9(6-10)19(21,22)23/h1-8H,(H,27,29)(H,28,30)(H2,24,25,26) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of c-kit (unknown origin) |
Bioorg Med Chem Lett 18: 5115-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50260888
(3-(2-aminoquinazolin-6-yl)-1-(2-cyclopentylethyl)-...)Show InChI InChI=1S/C21H24N4O/c1-14-8-10-25(11-9-15-4-2-3-5-15)20(26)19(14)16-6-7-18-17(12-16)13-23-21(22)24-18/h6-8,10,12-13,15H,2-5,9,11H2,1H3,(H2,22,23,24) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of c-Kit (unknown origin) by TR-FRET assay |
J Med Chem 51: 3065-8 (2008)
Article DOI: 10.1021/jm800188g BindingDB Entry DOI: 10.7270/Q2DN44TT |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50264392
(CHEMBL490823 | N-(6-acetamidopyridin-3-yl)-6-chlor...)Show SMILES CC(=O)Nc1ccc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(c4)C(F)(F)F)noc23)cn1 Show InChI InChI=1S/C22H15ClF3N5O3/c1-11(32)28-17-8-5-14(10-27-17)30-21(33)18-16(23)7-6-15-19(18)34-31-20(15)29-13-4-2-3-12(9-13)22(24,25)26/h2-10H,1H3,(H,29,31)(H,30,33)(H,27,28,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of c-kit (unknown origin) |
Bioorg Med Chem Lett 18: 5115-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365966
(CHEMBL1956237)Show InChI InChI=1S/C20H24N4O2/c1-6-13-7-14(10-21-20(13)23-12(2)3)16-11-22-24-17-9-19(26-5)18(25-4)8-15(16)17/h7-12H,6H2,1-5H3,(H,21,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365980
(CHEMBL1956251)Show SMILES COc1cc2nncc(-c3cnc(N4CCC(CC4)C(C)(C)O)c(c3)C(F)F)c2cc1OC Show InChI InChI=1S/C24H28F2N4O3/c1-24(2,31)15-5-7-30(8-6-15)23-17(22(25)26)9-14(12-27-23)18-13-28-29-19-11-21(33-4)20(32-3)10-16(18)19/h9-13,15,22,31H,5-8H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365982
(CHEMBL1956253)Show SMILES COc1cc2nncc(-c3cnc(N4CCC(CC4)C(C)(C)O)c(c3)C3CC3)c2cc1OC Show InChI InChI=1S/C26H32N4O3/c1-26(2,31)18-7-9-30(10-8-18)25-19(16-5-6-16)11-17(14-27-25)21-15-28-29-22-13-24(33-4)23(32-3)12-20(21)22/h11-16,18,31H,5-10H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365967
(CHEMBL1956238)Show SMILES COc1cc2nncc(-c3cnc(NC(C)C)c(c3)C3CC3)c2cc1OC Show InChI InChI=1S/C21H24N4O2/c1-12(2)24-21-15(13-5-6-13)7-14(10-22-21)17-11-23-25-18-9-20(27-4)19(26-3)8-16(17)18/h7-13H,5-6H2,1-4H3,(H,22,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365974
(CHEMBL1956245)Show InChI InChI=1S/C19H22N4O3/c1-11(2)22-19-13(10-24)5-12(8-20-19)15-9-21-23-16-7-18(26-4)17(25-3)6-14(15)16/h5-9,11,24H,10H2,1-4H3,(H,20,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365977
(CHEMBL1956248)Show SMILES COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)C4CC4)c(C)c3)c2cc1OC Show InChI InChI=1S/C24H28N4O3/c1-15-10-16(13-25-23(15)28-8-6-24(29,7-9-28)17-4-5-17)19-14-26-27-20-12-22(31-3)21(30-2)11-18(19)20/h10-14,17,29H,4-9H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479241
(US10894789, Compound 185)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H22F6N4OS/c1-13-9-23(26,27)12-34(18(13)11-32-19-8-5-16(10-31-19)24(28,29)30)22(35)20-21(36-14(2)33-20)15-3-6-17(25)7-4-15/h3-8,10,13,18H,9,11-12H2,1-2H3,(H,31,32)/t13-,18?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50264391
(CHEMBL523816 | N-(6-aminopyridin-3-yl)-6-chloro-3-...)Show SMILES Nc1ccc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(c4)C(F)(F)F)noc23)cn1 Show InChI InChI=1S/C20H13ClF3N5O2/c21-14-6-5-13-17(16(14)19(30)28-12-4-7-15(25)26-9-12)31-29-18(13)27-11-3-1-2-10(8-11)20(22,23)24/h1-9H,(H2,25,26)(H,27,29)(H,28,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of c-kit (unknown origin) |
Bioorg Med Chem Lett 18: 5115-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479268
(US10894789, Compound 65)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccccc1 |r| Show InChI InChI=1S/C23H22F5N5OS/c1-13-8-22(24,25)12-33(17(13)11-31-21-29-9-16(10-30-21)23(26,27)28)20(34)18-19(35-14(2)32-18)15-6-4-3-5-7-15/h3-7,9-10,13,17H,8,11-12H2,1-2H3,(H,29,30,31)/t13-,17?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479282
(US10894789, Compound 221)Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(Cl)cn1 |r| Show InChI InChI=1S/C22H21ClF5N7O/c1-12-5-21(24,25)11-35(17(12)9-32-20-30-6-13(7-31-20)22(26,27)28)19(36)18-15(10-34(2)33-18)16-4-3-14(23)8-29-16/h3-4,6-8,10,12,17H,5,9,11H2,1-2H3,(H,30,31,32)/t12-,17-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479169
(US10894789, Compound 125)Show SMILES COc1ccc(cc1)-c1cn(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1cnc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C24H25F5N6O2/c1-14-8-23(25,26)13-35(18(14)9-31-20-11-30-19(10-32-20)24(27,28)29)22(36)21-17(12-34(2)33-21)15-4-6-16(37-3)7-5-15/h4-7,10-12,14,18H,8-9,13H2,1-3H3,(H,31,32)/t14-,18?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479176
(US10894789, Compound 123)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1cccc(C)c1 |r| Show InChI InChI=1S/C24H25F5N6O/c1-14-5-4-6-16(7-14)17-12-34(3)33-21(17)22(36)35-13-23(25,26)8-15(2)18(35)9-31-20-11-30-19(10-32-20)24(27,28)29/h4-7,10-12,15,18H,8-9,13H2,1-3H3,(H,31,32)/t15-,18?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479203
(US10894789, Compound 78)Show SMILES COc1ccc(nc1)-c1sc(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1ncc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C23H23F5N6O2S/c1-12-6-22(24,25)11-34(17(12)10-32-21-30-7-14(8-31-21)23(26,27)28)20(35)18-19(37-13(2)33-18)16-5-4-15(36-3)9-29-16/h4-5,7-9,12,17H,6,10-11H2,1-3H3,(H,30,31,32)/t12-,17?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479227
(US10894789, Compound 211)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccccn1 |r| Show InChI InChI=1S/C22H21F5N6OS/c1-12-7-21(23,24)11-33(15(12)8-30-17-10-29-16(9-31-17)22(25,26)27)20(34)18-19(35-13(2)32-18)14-5-3-4-6-28-14/h3-6,9-10,12,15H,7-8,11H2,1-2H3,(H,30,31)/t12-,15?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479229
(US10894789, Compound 120)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccccc1 |r| Show InChI InChI=1S/C23H23F5N6O/c1-14-8-22(24,25)13-34(17(14)9-30-19-11-29-18(10-31-19)23(26,27)28)21(35)20-16(12-33(2)32-20)15-6-4-3-5-7-15/h3-7,10-12,14,17H,8-9,13H2,1-2H3,(H,30,31)/t14-,17?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479230
(US10894789, Compound 21)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccccc1 |r| Show InChI InChI=1S/C23H23F5N6O/c1-14-8-22(24,25)13-34(18(14)11-31-21-29-9-16(10-30-21)23(26,27)28)20(35)19-17(12-33(2)32-19)15-6-4-3-5-7-15/h3-7,9-10,12,14,18H,8,11,13H2,1-2H3,(H,29,30,31)/t14-,18?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50243125
(CHEMBL487864 | N3-(6-acetamidopyridin-3-yl)-4-meth...)Show SMILES CC(=O)Nc1ccc(NC(=O)c2cc(ccc2C)C(=O)Nc2cccc(c2)C(F)(F)F)cn1 Show InChI InChI=1S/C23H19F3N4O3/c1-13-6-7-15(21(32)29-17-5-3-4-16(11-17)23(24,25)26)10-19(13)22(33)30-18-8-9-20(27-12-18)28-14(2)31/h3-12H,1-2H3,(H,29,32)(H,30,33)(H,27,28,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of c-kit (unknown origin) |
Bioorg Med Chem Lett 18: 4137-41 (2008)
Article DOI: 10.1016/j.bmcl.2008.05.089 BindingDB Entry DOI: 10.7270/Q20001WP |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365964
(CHEMBL1956235 | CHEMBL2070530)Show InChI InChI=1S/C19H22N4O2/c1-11(2)22-19-12(3)6-13(9-20-19)15-10-21-23-16-8-18(25-5)17(24-4)7-14(15)16/h6-11H,1-5H3,(H,20,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479243
(US10894789, Compound 169)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H23F6N5O/c1-14-9-23(26,27)13-35(19(14)11-32-20-8-5-16(10-31-20)24(28,29)30)22(36)21-18(12-34(2)33-21)15-3-6-17(25)7-4-15/h3-8,10,12,14,19H,9,11,13H2,1-2H3,(H,31,32)/t14-,19?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50260890
(3-(2-aminoquinazolin-6-yl)-1-(4-tert-butylphenyl)-...)Show SMILES Cc1ccn(-c2ccc(cc2)C(C)(C)C)c(=O)c1-c1ccc2nc(N)ncc2c1 Show InChI InChI=1S/C24H24N4O/c1-15-11-12-28(19-8-6-18(7-9-19)24(2,3)4)22(29)21(15)16-5-10-20-17(13-16)14-26-23(25)27-20/h5-14H,1-4H3,(H2,25,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc
Curated by ChEMBL
| Assay Description Inhibition of c-Kit (unknown origin) by TR-FRET assay |
J Med Chem 51: 3065-8 (2008)
Article DOI: 10.1021/jm800188g BindingDB Entry DOI: 10.7270/Q2DN44TT |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365968
(CHEMBL1956239)Show SMILES COc1cc2nncc(-c3cnc(NC(C)C)c(c3)C(F)F)c2cc1OC Show InChI InChI=1S/C19H20F2N4O2/c1-10(2)24-19-13(18(20)21)5-11(8-22-19)14-9-23-25-15-7-17(27-4)16(26-3)6-12(14)15/h5-10,18H,1-4H3,(H,22,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365973
(CHEMBL1956244)Show SMILES COc1cc2nncc(-c3cnc(NC(C)C)c(c3)C(C)(C)O)c2cc1OC Show InChI InChI=1S/C21H26N4O3/c1-12(2)24-20-16(21(3,4)26)7-13(10-22-20)15-11-23-25-17-9-19(28-6)18(27-5)8-14(15)17/h7-12,26H,1-6H3,(H,22,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365975
(CHEMBL1956246)Show SMILES COc1cc2nncc(-c3cnc(N4CCC(O)(CC4)c4ccccn4)c(C)c3)c2cc1OC Show InChI InChI=1S/C26H27N5O3/c1-17-12-18(20-16-29-30-21-14-23(34-3)22(33-2)13-19(20)21)15-28-25(17)31-10-7-26(32,8-11-31)24-6-4-5-9-27-24/h4-6,9,12-16,32H,7-8,10-11H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479239
(US10894789, Compound 30)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C23H22F6N6O/c1-13-7-22(25,26)12-35(18(13)10-32-21-30-8-15(9-31-21)23(27,28)29)20(36)19-17(11-34(2)33-19)14-3-5-16(24)6-4-14/h3-6,8-9,11,13,18H,7,10,12H2,1-2H3,(H,30,31,32)/t13-,18?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479308
(US10894789, Compound 264)Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)c(C)c1-c1ncc(F)cn1 |r| Show InChI InChI=1S/C22H22F6N8O/c1-11-4-21(24,25)10-36(15(11)9-33-20-31-5-13(6-32-20)22(26,27)28)19(37)17-16(12(2)35(3)34-17)18-29-7-14(23)8-30-18/h5-8,11,15H,4,9-10H2,1-3H3,(H,31,32,33)/t11-,15-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479157
(US10894789, Compound 197)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(C)cn1 |r| Show InChI InChI=1S/C24H24F5N5OS/c1-13-4-6-17(30-9-13)21-20(33-15(3)36-21)22(35)34-12-23(25,26)8-14(2)18(34)11-32-19-7-5-16(10-31-19)24(27,28)29/h4-7,9-10,14,18H,8,11-12H2,1-3H3,(H,31,32)/t14-,18?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479174
(US10894789, Compound 63)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1cccc(C)c1 |r| Show InChI InChI=1S/C24H24F5N5OS/c1-13-5-4-6-16(7-13)20-19(33-15(3)36-20)21(35)34-12-23(25,26)8-14(2)18(34)11-32-22-30-9-17(10-31-22)24(27,28)29/h4-7,9-10,14,18H,8,11-12H2,1-3H3,(H,30,31,32)/t14-,18?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479190
(US10894789, Compound 23)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccccc1F |r| Show InChI InChI=1S/C23H22F6N6O/c1-13-7-22(25,26)12-35(18(13)10-32-21-30-8-14(9-31-21)23(27,28)29)20(36)19-16(11-34(2)33-19)15-5-3-4-6-17(15)24/h3-6,8-9,11,13,18H,7,10,12H2,1-2H3,(H,30,31,32)/t13-,18?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50264389
(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethyl)...)Show SMILES FC(F)(F)c1cccc(Nc2noc3c(C(=O)Nc4cncnc4)c(Cl)ccc23)c1 Show InChI InChI=1S/C19H11ClF3N5O2/c20-14-5-4-13-16(15(14)18(29)27-12-7-24-9-25-8-12)30-28-17(13)26-11-3-1-2-10(6-11)19(21,22)23/h1-9H,(H,26,28)(H,27,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of c-kit (unknown origin) |
Bioorg Med Chem Lett 18: 5115-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479201
(US10894789, Compound 150)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1cc(F)ccn1 |r| Show InChI InChI=1S/C22H20F6N6OS/c1-11-6-21(24,25)10-34(15(11)7-31-17-9-30-16(8-32-17)22(26,27)28)20(35)18-19(36-12(2)33-18)14-5-13(23)3-4-29-14/h3-5,8-9,11,15H,6-7,10H2,1-2H3,(H,31,32)/t11-,15?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50264220
(2-(1,6-diphenyl-1H-imidazo[4,5-c]pyridine-4-carbox...)Show SMILES OC(=O)CNC(=O)c1nc(cc2n(cnc12)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C21H16N4O3/c26-18(27)12-22-21(28)20-19-17(11-16(24-20)14-7-3-1-4-8-14)25(13-23-19)15-9-5-2-6-10-15/h1-11,13H,12H2,(H,22,28)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description Inhibition of PHD2 (unknown origin) by fluorescence energy transfer analysis |
Bioorg Med Chem Lett 18: 5023-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.08.012 BindingDB Entry DOI: 10.7270/Q2ZS2WB7 |
More data for this Ligand-Target Pair | |
Egl nine homolog 1
(Homo sapiens (Human)) | BDBM50251959
(2-(2-(2-(4-tert-butylbenzylsulfonyl)acetamido)-3-h...)Show SMILES CC(C)(C)c1ccc(CS(=O)(=O)CC(=O)N=c2scc(CC(O)=O)n2O)cc1 |w:15.14| Show InChI InChI=1S/C18H22N2O6S2/c1-18(2,3)13-6-4-12(5-7-13)10-28(25,26)11-15(21)19-17-20(24)14(9-27-17)8-16(22)23/h4-7,9,24H,8,10-11H2,1-3H3,(H,22,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human PHD2 assesssed as hydroxylation of Pro564 in human HIF-1alpha by TR-FRET assay |
Bioorg Med Chem Lett 18: 3925-8 (2008)
Article DOI: 10.1016/j.bmcl.2008.06.031 BindingDB Entry DOI: 10.7270/Q2XW4JM5 |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365956
(CHEMBL1956228)Show InChI InChI=1S/C19H20N4O2/c1-24-17-7-14-15(11-22-23-16(14)8-18(17)25-2)13-5-6-19(21-10-13)20-9-12-3-4-12/h5-8,10-12H,3-4,9H2,1-2H3,(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50264439
(6-chloro-N-(pyridin-3-yl)-3-(3-(trifluoromethyl)ph...)Show SMILES FC(F)(F)c1cccc(Nc2noc3c(C(=O)Nc4cccnc4)c(Cl)ccc23)c1 Show InChI InChI=1S/C20H12ClF3N4O2/c21-15-7-6-14-17(16(15)19(29)27-13-5-2-8-25-10-13)30-28-18(14)26-12-4-1-3-11(9-12)20(22,23)24/h1-10H,(H,26,28)(H,27,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of c-kit (unknown origin) |
Bioorg Med Chem Lett 18: 5115-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH |
More data for this Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50365978
(CHEMBL1956249)Show SMILES COc1cc2nncc(-c3cnc(N4CCC(C)(O)CC4)c(C)c3)c2cc1OC Show InChI InChI=1S/C22H26N4O3/c1-14-9-15(12-23-21(14)26-7-5-22(2,27)6-8-26)17-13-24-25-18-11-20(29-4)19(28-3)10-16(17)18/h9-13,27H,5-8H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 2262-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.086 BindingDB Entry DOI: 10.7270/Q2ZK5H42 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479238
(US10894789, Compound 31)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ncc(Cl)cn1)C(=O)c1nn(C)cc1-c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H22ClF3N6O/c1-13-7-22(25,26)12-32(18(13)10-29-21-27-8-15(23)9-28-21)20(33)19-17(11-31(2)30-19)14-3-5-16(24)6-4-14/h3-6,8-9,11,13,18H,7,10,12H2,1-2H3,(H,27,28,29)/t13-,18?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Mast/stem cell growth factor receptor Kit
(Homo sapiens (Human)) | BDBM50264363
(6-chloro-N-(pyrimidin-5-yl)-3-(3-(trifluoromethoxy...)Show SMILES FC(F)(F)Oc1cccc(Nc2noc3c(C(=O)Nc4cncnc4)c(Cl)ccc23)c1 Show InChI InChI=1S/C19H11ClF3N5O3/c20-14-5-4-13-16(15(14)18(29)27-11-7-24-9-25-8-11)31-28-17(13)26-10-2-1-3-12(6-10)30-19(21,22)23/h1-9H,(H,26,28)(H,27,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of c-kit (unknown origin) |
Bioorg Med Chem Lett 18: 5115-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.111 BindingDB Entry DOI: 10.7270/Q2B56JJH |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479272
(US10894789, Compound 216)Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1COc1ccc(cn1)C(F)(F)F)C(=O)c1cc(Cl)ccc1-c1nnn(C)n1 |r| Show InChI InChI=1S/C22H20ClF5N6O2/c1-12-8-21(24,25)11-34(17(12)10-36-18-6-3-13(9-29-18)22(26,27)28)20(35)16-7-14(23)4-5-15(16)19-30-32-33(2)31-19/h3-7,9,12,17H,8,10-11H2,1-2H3/t12-,17-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479273
(US10894789, Compound 217)Show SMILES C[C@@H]1CC(F)(F)CN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ncc(F)cn1 |r| Show InChI InChI=1S/C21H20F6N8O/c1-11-3-20(23,24)10-35(15(11)8-32-19-30-4-12(5-31-19)21(25,26)27)18(36)16-14(9-34(2)33-16)17-28-6-13(22)7-29-17/h4-7,9,11,15H,3,8,10H2,1-2H3,(H,30,31,32)/t11-,15-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479158
(US10894789, Compound 175)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1ccc(C)cc1 |r| Show InChI InChI=1S/C25H26F5N5O/c1-15-4-6-17(7-5-15)19-13-34(3)33-22(19)23(36)35-14-24(26,27)10-16(2)20(35)12-32-21-9-8-18(11-31-21)25(28,29)30/h4-9,11,13,16,20H,10,12,14H2,1-3H3,(H,31,32)/t16-,20?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479159
(US10894789, Compound 174)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)ccc1-n1nccn1 |r| Show InChI InChI=1S/C22H22F5N7O/c1-13-9-21(23,24)12-33(17(13)11-29-18-6-4-15(10-28-18)22(25,26)27)20(35)19-16(5-3-14(2)32-19)34-30-7-8-31-34/h3-8,10,13,17H,9,11-12H2,1-2H3,(H,28,29)/t13-,17?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479165
(US10894789, Compound 29)Show SMILES COc1cccc(c1)-c1cn(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1ncc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C24H25F5N6O2/c1-14-8-23(25,26)13-35(19(14)11-32-22-30-9-16(10-31-22)24(27,28)29)21(36)20-18(12-34(2)33-20)15-5-4-6-17(7-15)37-3/h4-7,9-10,12,14,19H,8,11,13H2,1-3H3,(H,30,31,32)/t14-,19?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479168
(US10894789, Compound 124)Show SMILES COc1cccc(c1)-c1cn(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1cnc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C24H25F5N6O2/c1-14-8-23(25,26)13-35(18(14)9-31-20-11-30-19(10-32-20)24(27,28)29)22(36)21-17(12-34(2)33-21)15-5-4-6-16(7-15)37-3/h4-7,10-12,14,18H,8-9,13H2,1-3H3,(H,31,32)/t14-,18?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479169
(US10894789, Compound 125)Show SMILES COc1ccc(cc1)-c1cn(C)nc1C(=O)N1CC(F)(F)C[C@@H](C)C1CNc1cnc(cn1)C(F)(F)F |r| Show InChI InChI=1S/C24H25F5N6O2/c1-14-8-23(25,26)13-35(18(14)9-31-20-11-30-19(10-32-20)24(27,28)29)22(36)21-17(12-34(2)33-21)15-4-6-16(37-3)7-5-15/h4-7,10-12,14,18H,8-9,13H2,1-3H3,(H,31,32)/t14-,18?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |
Orexin/Hypocretin receptor type 1
(Homo sapiens (Human)) | BDBM479175
(US10894789, Compound 134)Show SMILES C[C@@H]1CC(F)(F)CN(C1CNc1cnc(cn1)C(F)(F)F)C(=O)c1nn(C)cc1-c1cc(C)ccn1 |r| Show InChI InChI=1S/C23H24F5N7O/c1-13-4-5-29-16(6-13)15-11-34(3)33-20(15)21(36)35-12-22(24,25)7-14(2)17(35)8-31-19-10-30-18(9-32-19)23(26,27)28/h4-6,9-11,14,17H,7-8,12H2,1-3H3,(H,31,32)/t14-,17?/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
ASTRAZENECA AB; EOLAS THERAPEUTICS, INC.
US Patent
| Assay Description Measurement of [Ca2+]i using a FLIPR: CHO—OX1 or CHO—OX2 cells were seeded into black-walled clear-base 384-well plates (Corning, catalog #3712) at a... |
US Patent US10894789 (2021)
BindingDB Entry DOI: 10.7270/Q29K4F96 |
More data for this Ligand-Target Pair | |