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Compile Data Set for Download or QSAR

Found 387 hits with Last Name = 'baevsky' and Initial = 'm'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149427
PNG
(US10434101, Compound I-29 | US11096942, Compound I...)
Show SMILES COC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H28F3N7O4/c1-4-23(38)32-17-6-5-7-18(14-17)33-24-20(27(28,29)30)16-31-25(35-24)34-21-9-8-19(15-22(21)40-2)36-10-12-37(13-11-36)26(39)41-3/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,38)(H2,31,33,34,35)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149428
PNG
(US10434101, Compound I-30 | US11096942, Compound I...)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C27H25F6N7O4/c1-2-22(42)35-16-4-3-5-17(12-16)36-24-19(26(28,29)30)14-34-25(38-24)37-20-7-6-18(13-21(20)44-27(31,32)33)39-8-10-40(11-9-39)23(43)15-41/h2-7,12-14,41H,1,8-11,15H2,(H,35,42)(H2,34,36,37,38)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149429
PNG
(US10434101, Compound I-31 | US11096942, Compound I...)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O4/c1-2-22(41)34-16-4-3-5-17(12-16)35-24-19(27(30,31)32)14-33-26(37-24)36-20-7-6-18(13-21(20)43-25(28)29)38-8-10-39(11-9-38)23(42)15-40/h2-7,12-14,25,40H,1,8-11,15H2,(H,34,41)(H2,33,35,36,37)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149429
PNG
(US10434101, Compound I-31 | US11096942, Compound I...)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O4/c1-2-22(41)34-16-4-3-5-17(12-16)35-24-19(27(30,31)32)14-33-26(37-24)36-20-7-6-18(13-21(20)43-25(28)29)38-8-10-39(11-9-38)23(42)15-40/h2-7,12-14,25,40H,1,8-11,15H2,(H,34,41)(H2,33,35,36,37)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149402
PNG
(US10434101, Compound I-2 | US11096942, Compound I-...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H25F3N6O3/c1-3-22(35)30-16-5-4-6-17(13-16)31-23-19(25(26,27)28)15-29-24(33-23)32-20-8-7-18(14-21(20)36-2)34-9-11-37-12-10-34/h3-8,13-15H,1,9-12H2,2H3,(H,30,35)(H2,29,31,32,33)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149403
PNG
(US10434101, Compound I-3 | US11096942, Compound I-...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C26H27ClN6O5/c1-3-23(35)29-17-5-4-6-19(13-17)38-25-20(27)15-28-26(31-25)30-21-8-7-18(14-22(21)37-2)32-9-11-33(12-10-32)24(36)16-34/h3-8,13-15,34H,1,9-12,16H2,2H3,(H,29,35)(H,28,30,31)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149404
PNG
(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149406
PNG
(US10434101, Compound I-6 | US11096942, Compound I-...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C27H28F3N7O4/c1-3-23(39)32-17-5-4-6-18(13-17)33-25-20(27(28,29)30)15-31-26(35-25)34-21-8-7-19(14-22(21)41-2)36-9-11-37(12-10-36)24(40)16-38/h3-8,13-15,38H,1,9-12,16H2,2H3,(H,32,39)(H2,31,33,34,35)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149407
PNG
(US10434101, Compound I-7 | US11096942, Compound I-...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCN(CC1)C(C)=O
Show InChI InChI=1S/C28H30F3N7O3/c1-4-25(40)33-19-7-5-8-20(15-19)34-26-22(28(29,30)31)17-32-27(36-26)35-23-10-9-21(16-24(23)41-3)38-12-6-11-37(13-14-38)18(2)39/h4-5,7-10,15-17H,1,6,11-14H2,2-3H3,(H,33,40)(H2,32,34,35,36)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149409
PNG
(US10434101, Compound I-9 | US11096942, Compound I-...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C26H27ClN6O4/c1-4-24(35)29-18-6-5-7-20(14-18)37-25-21(27)16-28-26(31-25)30-22-9-8-19(15-23(22)36-3)33-12-10-32(11-13-33)17(2)34/h4-9,14-16H,1,10-13H2,2-3H3,(H,29,35)(H,28,30,31)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149411
PNG
(US10434101, Compound I-11 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C27H27F3N6O5/c1-3-23(38)32-17-5-4-6-19(13-17)41-25-20(27(28,29)30)15-31-26(34-25)33-21-8-7-18(14-22(21)40-2)35-9-11-36(12-10-35)24(39)16-37/h3-8,13-15,37H,1,9-12,16H2,2H3,(H,32,38)(H,31,33,34)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149412
PNG
(US10434101, Compound I-12 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C26H28ClN7O4/c1-3-23(36)29-17-5-4-6-18(13-17)30-25-20(27)15-28-26(32-25)31-21-8-7-19(14-22(21)38-2)33-9-11-34(12-10-33)24(37)16-35/h3-8,13-15,35H,1,9-12,16H2,2H3,(H,29,36)(H2,28,30,31,32)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149413
PNG
(US10434101, Compound I-13 | US11096942, Compound I...)
Show SMILES FC(F)Oc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H22F5N5O4/c1-2-21(36)32-15-4-3-5-17(12-15)38-22-18(25(28,29)30)14-31-24(34-22)33-19-7-6-16(13-20(19)39-23(26)27)35-8-10-37-11-9-35/h2-7,12-14,23H,1,8-11H2,(H,32,36)(H,31,33,34)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149414
PNG
(US10434101, Compound I-14 | US11096942, Compound I...)
Show SMILES FC(F)Oc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H23F5N6O3/c1-2-21(37)32-15-4-3-5-16(12-15)33-22-18(25(28,29)30)14-31-24(35-22)34-19-7-6-17(13-20(19)39-23(26)27)36-8-10-38-11-9-36/h2-7,12-14,23H,1,8-11H2,(H,32,37)(H2,31,33,34,35)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149416
PNG
(US10434101, Compound I-17 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C26H28F3N7O4S/c1-4-23(37)31-17-6-5-7-18(14-17)32-24-20(26(27,28)29)16-30-25(34-24)33-21-9-8-19(15-22(21)40-2)35-10-12-36(13-11-35)41(3,38)39/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,37)(H2,30,32,33,34)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149420
PNG
(US10434101, Compound I-21 | US11096942, Compound I...)
Show SMILES CNC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H28F3N7O4/c1-4-23(38)33-17-6-5-7-19(14-17)41-24-20(27(28,29)30)16-32-25(35-24)34-21-9-8-18(15-22(21)40-3)36-10-12-37(13-11-36)26(39)31-2/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,39)(H,33,38)(H,32,34,35)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149421
PNG
(US10434101, Compound I-22 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C26H27F3N6O5S/c1-4-23(36)31-17-6-5-7-19(14-17)40-24-20(26(27,28)29)16-30-25(33-24)32-21-9-8-18(15-22(21)39-2)34-10-12-35(13-11-34)41(3,37)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,36)(H,30,32,33)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149430
PNG
(US10434101, Compound I-32 | US11096942, Compound I...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O3/c1-3-23(41)34-17-5-4-6-18(13-17)35-24-20(27(30,31)32)15-33-26(37-24)36-21-8-7-19(14-22(21)42-25(28)29)39-11-9-38(10-12-39)16(2)40/h3-8,13-15,25H,1,9-12H2,2H3,(H,34,41)(H2,33,35,36,37)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149430
PNG
(US10434101, Compound I-32 | US11096942, Compound I...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O3/c1-3-23(41)34-17-5-4-6-18(13-17)35-24-20(27(30,31)32)15-33-26(37-24)36-21-8-7-19(14-22(21)42-25(28)29)39-11-9-38(10-12-39)16(2)40/h3-8,13-15,25H,1,9-12H2,2H3,(H,34,41)(H2,33,35,36,37)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149431
PNG
(US10434101, Compound I-33 | US11096942, Compound I...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C27H25F6N7O3/c1-3-23(42)35-17-5-4-6-18(13-17)36-24-20(26(28,29)30)15-34-25(38-24)37-21-8-7-19(14-22(21)43-27(31,32)33)40-11-9-39(10-12-40)16(2)41/h3-8,13-15H,1,9-12H2,2H3,(H,35,42)(H2,34,36,37,38)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149432
PNG
(US10434101, Compound I-34 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)C(C)(C)C
Show InChI InChI=1S/C30H34F3N7O3/c1-6-25(41)35-19-8-7-9-20(16-19)36-26-22(30(31,32)33)18-34-28(38-26)37-23-11-10-21(17-24(23)43-5)39-12-14-40(15-13-39)27(42)29(2,3)4/h6-11,16-18H,1,12-15H2,2-5H3,(H,35,41)(H2,34,36,37,38)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149433
PNG
(US10434101, Compound I-35 | US11096942, Compound I...)
Show SMILES CCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C28H30F3N7O3/c1-4-24(39)33-18-7-6-8-19(15-18)34-26-21(28(29,30)31)17-32-27(36-26)35-22-10-9-20(16-23(22)41-3)37-11-13-38(14-12-37)25(40)5-2/h4,6-10,15-17H,1,5,11-14H2,2-3H3,(H,33,39)(H2,32,34,35,36)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149434
PNG
(US10434101, Compound I-36 | US11096942, Compound I...)
Show SMILES FC(F)Oc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCOCC1
Show InChI InChI=1S/C24H22ClF2N5O4/c1-2-21(33)29-15-4-3-5-17(12-15)35-22-18(25)14-28-24(31-22)30-19-7-6-16(13-20(19)36-23(26)27)32-8-10-34-11-9-32/h2-7,12-14,23H,1,8-11H2,(H,29,33)(H,28,30,31)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149436
PNG
(US10434101, Compound I-38 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCOCC1
Show InChI InChI=1S/C26H27F3N6O3/c1-3-23(36)31-17-6-4-7-18(14-17)32-24-20(26(27,28)29)16-30-25(34-24)33-21-9-8-19(15-22(21)37-2)35-10-5-12-38-13-11-35/h3-4,6-9,14-16H,1,5,10-13H2,2H3,(H,31,36)(H2,30,32,33,34)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149444
PNG
(US10434101, Compound I-46 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C29H33ClN6O5/c1-6-25(37)32-19-8-7-9-21(16-19)40-26-22(30)18-31-27(34-26)33-23-11-10-20(17-24(23)39-5)35-12-14-36(15-13-35)28(38)41-29(2,3)4/h6-11,16-18H,1,12-15H2,2-5H3,(H,32,37)(H,31,33,34)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149446
PNG
(US10434101, Compound I-48 | US11096942, Compound I...)
Show SMILES COC(=O)[C@@H]1CN(CCN1C(C)=O)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1 |r|
Show InChI InChI=1S/C29H30F3N7O5/c1-5-25(41)34-18-7-6-8-19(13-18)35-26-21(29(30,31)32)15-33-28(37-26)36-22-10-9-20(14-24(22)43-3)38-11-12-39(17(2)40)23(16-38)27(42)44-4/h5-10,13-15,23H,1,11-12,16H2,2-4H3,(H,34,41)(H2,33,35,36,37)/t23-/m0/s1
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor [T790M,L858R]


(Homo sapiens (Human))		BDBM149447
PNG
(US10434101, Compound I-49 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCS(=O)(=O)CC1
Show InChI InChI=1S/C25H25F3N6O4S/c1-3-22(35)30-16-5-4-6-17(13-16)31-23-19(25(26,27)28)15-29-24(33-23)32-20-8-7-18(14-21(20)38-2)34-9-11-39(36,37)12-10-34/h3-8,13-15H,1,9-12H2,2H3,(H,30,35)(H2,29,31,32,33)
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n/an/a<1n/an/an/an/an/an/a


TBA

Assay Description
Briefly, 10× stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13×ATP (AS001A) and ap...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2GT5RBQ
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149429
PNG
(US10434101, Compound I-31 | US11096942, Compound I...)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O4/c1-2-22(41)34-16-4-3-5-17(12-16)35-24-19(27(30,31)32)14-33-26(37-24)36-20-7-6-18(13-21(20)43-25(28)29)38-8-10-39(11-9-38)23(42)15-40/h2-7,12-14,25,40H,1,8-11,15H2,(H,34,41)(H2,33,35,36,37)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149430
PNG
(US10434101, Compound I-32 | US11096942, Compound I...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O3/c1-3-23(41)34-17-5-4-6-18(13-17)35-24-20(27(30,31)32)15-33-26(37-24)36-21-8-7-19(14-22(21)42-25(28)29)39-11-9-38(10-12-39)16(2)40/h3-8,13-15,25H,1,9-12H2,2H3,(H,34,41)(H2,33,35,36,37)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149402
PNG
(US10434101, Compound I-2 | US11096942, Compound I-...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H25F3N6O3/c1-3-22(35)30-16-5-4-6-17(13-16)31-23-19(25(26,27)28)15-29-24(33-23)32-20-8-7-18(14-21(20)36-2)34-9-11-37-12-10-34/h3-8,13-15H,1,9-12H2,2H3,(H,30,35)(H2,29,31,32,33)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149403
PNG
(US10434101, Compound I-3 | US11096942, Compound I-...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C26H27ClN6O5/c1-3-23(35)29-17-5-4-6-19(13-17)38-25-20(27)15-28-26(31-25)30-21-8-7-18(14-22(21)37-2)32-9-11-33(12-10-32)24(36)16-34/h3-8,13-15,34H,1,9-12,16H2,2H3,(H,29,35)(H,28,30,31)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149404
PNG
(AVL-301 | CHEMBL3545308 | CNX-419 | CO-1686 | Roci...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149406
PNG
(US10434101, Compound I-6 | US11096942, Compound I-...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C27H28F3N7O4/c1-3-23(39)32-17-5-4-6-18(13-17)33-25-20(27(28,29)30)15-31-26(35-25)34-21-8-7-19(14-22(21)41-2)36-9-11-37(12-10-36)24(40)16-38/h3-8,13-15,38H,1,9-12,16H2,2H3,(H,32,39)(H2,31,33,34,35)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149407
PNG
(US10434101, Compound I-7 | US11096942, Compound I-...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCCN(CC1)C(C)=O
Show InChI InChI=1S/C28H30F3N7O3/c1-4-25(40)33-19-7-5-8-20(15-19)34-26-22(28(29,30)31)17-32-27(36-26)35-23-10-9-21(16-24(23)41-3)38-12-6-11-37(13-14-38)18(2)39/h4-5,7-10,15-17H,1,6,11-14H2,2-3H3,(H,33,40)(H2,32,34,35,36)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149409
PNG
(US10434101, Compound I-9 | US11096942, Compound I-...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(C)=O
Show InChI InChI=1S/C26H27ClN6O4/c1-4-24(35)29-18-6-5-7-20(14-18)37-25-21(27)16-28-26(31-25)30-22-9-8-19(15-23(22)36-3)33-12-10-32(11-13-33)17(2)34/h4-9,14-16H,1,10-13H2,2-3H3,(H,29,35)(H,28,30,31)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149411
PNG
(US10434101, Compound I-11 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C27H27F3N6O5/c1-3-23(38)32-17-5-4-6-19(13-17)41-25-20(27(28,29)30)15-31-26(34-25)33-21-8-7-18(14-22(21)40-2)35-9-11-36(12-10-35)24(39)16-37/h3-8,13-15,37H,1,9-12,16H2,2H3,(H,32,38)(H,31,33,34)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149412
PNG
(US10434101, Compound I-12 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)C(=O)CO
Show InChI InChI=1S/C26H28ClN7O4/c1-3-23(36)29-17-5-4-6-18(13-17)30-25-20(27)15-28-26(32-25)31-21-8-7-19(14-22(21)38-2)33-9-11-34(12-10-33)24(37)16-35/h3-8,13-15,35H,1,9-12,16H2,2H3,(H,29,36)(H2,28,30,31,32)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149413
PNG
(US10434101, Compound I-13 | US11096942, Compound I...)
Show SMILES FC(F)Oc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H22F5N5O4/c1-2-21(36)32-15-4-3-5-17(12-15)38-22-18(25(28,29)30)14-31-24(34-22)33-19-7-6-16(13-20(19)39-23(26)27)35-8-10-37-11-9-35/h2-7,12-14,23H,1,8-11H2,(H,32,36)(H,31,33,34)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149414
PNG
(US10434101, Compound I-14 | US11096942, Compound I...)
Show SMILES FC(F)Oc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCOCC1
Show InChI InChI=1S/C25H23F5N6O3/c1-2-21(37)32-15-4-3-5-16(12-15)33-22-18(25(28,29)30)14-31-24(35-22)34-19-7-6-17(13-20(19)39-23(26)27)36-8-10-38-11-9-36/h2-7,12-14,23H,1,8-11H2,(H,32,37)(H2,31,33,34,35)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149416
PNG
(US10434101, Compound I-17 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C26H28F3N7O4S/c1-4-23(37)31-17-6-5-7-18(14-17)32-24-20(26(27,28)29)16-30-25(34-24)33-21-9-8-19(15-22(21)40-2)35-10-12-36(13-11-35)41(3,38)39/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,37)(H2,30,32,33,34)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149420
PNG
(US10434101, Compound I-21 | US11096942, Compound I...)
Show SMILES CNC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Oc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H28F3N7O4/c1-4-23(38)33-17-6-5-7-19(14-17)41-24-20(27(28,29)30)16-32-25(35-24)34-21-9-8-18(15-22(21)40-3)36-10-12-37(13-11-36)26(39)31-2/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,39)(H,33,38)(H,32,34,35)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149421
PNG
(US10434101, Compound I-22 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Oc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C26H27F3N6O5S/c1-4-23(36)31-17-6-5-7-19(14-17)40-24-20(26(27,28)29)16-30-25(33-24)32-21-9-8-18(15-22(21)39-2)34-10-12-35(13-11-34)41(3,37)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,36)(H,30,32,33)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149424
PNG
(US10434101, Compound I-26 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(CC1)S(C)(=O)=O
Show InChI InChI=1S/C25H27ClN6O5S/c1-4-23(33)28-17-6-5-7-19(14-17)37-24-20(26)16-27-25(30-24)29-21-9-8-18(15-22(21)36-2)31-10-12-32(13-11-31)38(3,34)35/h4-9,14-16H,1,10-13H2,2-3H3,(H,28,33)(H,27,29,30)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149426
PNG
(US10434101, Compound I-28 | US11096942, Compound I...)
Show SMILES CNC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H29F3N8O3/c1-4-23(39)33-17-6-5-7-18(14-17)34-24-20(27(28,29)30)16-32-25(36-24)35-21-9-8-19(15-22(21)41-3)37-10-12-38(13-11-37)26(40)31-2/h4-9,14-16H,1,10-13H2,2-3H3,(H,31,40)(H,33,39)(H2,32,34,35,36)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149427
PNG
(US10434101, Compound I-29 | US11096942, Compound I...)
Show SMILES COC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC)c1
Show InChI InChI=1S/C27H28F3N7O4/c1-4-23(38)32-17-6-5-7-18(14-17)33-24-20(27(28,29)30)16-31-25(35-24)34-21-9-8-19(15-22(21)40-2)36-10-12-37(13-11-36)26(39)41-3/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,38)(H2,31,33,34,35)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149428
PNG
(US10434101, Compound I-30 | US11096942, Compound I...)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C27H25F6N7O4/c1-2-22(42)35-16-4-3-5-17(12-16)36-24-19(26(28,29)30)14-34-25(38-24)37-20-7-6-18(13-21(20)44-27(31,32)33)39-8-10-40(11-9-39)23(43)15-41/h2-7,12-14,41H,1,8-11,15H2,(H,35,42)(H2,34,36,37,38)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149429
PNG
(US10434101, Compound I-31 | US11096942, Compound I...)
Show SMILES OCC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O4/c1-2-22(41)34-16-4-3-5-17(12-16)35-24-19(27(30,31)32)14-33-26(37-24)36-20-7-6-18(13-21(20)43-25(28)29)38-8-10-39(11-9-38)23(42)15-40/h2-7,12-14,25,40H,1,8-11,15H2,(H,34,41)(H2,33,35,36,37)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149430
PNG
(US10434101, Compound I-32 | US11096942, Compound I...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)F)c1
Show InChI InChI=1S/C27H26F5N7O3/c1-3-23(41)34-17-5-4-6-18(13-17)35-24-20(27(30,31)32)15-33-26(37-24)36-21-8-7-19(14-22(21)42-25(28)29)39-11-9-38(10-12-39)16(2)40/h3-8,13-15,25H,1,9-12H2,2H3,(H,34,41)(H2,33,35,36,37)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149431
PNG
(US10434101, Compound I-33 | US11096942, Compound I...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(c(Nc3cccc(NC(=O)C=C)c3)n2)C(F)(F)F)c(OC(F)(F)F)c1
Show InChI InChI=1S/C27H25F6N7O3/c1-3-23(42)35-17-5-4-6-18(13-17)36-24-20(26(28,29)30)15-34-25(38-24)37-21-8-7-19(14-22(21)43-27(31,32)33)40-11-9-39(10-12-40)16(2)41/h3-8,13-15H,1,9-12H2,2H3,(H,35,42)(H2,34,36,37,38)
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Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM149432
PNG
(US10434101, Compound I-34 | US11096942, Compound I...)
Show SMILES COc1cc(ccc1Nc1ncc(c(Nc2cccc(NC(=O)C=C)c2)n1)C(F)(F)F)N1CCN(CC1)C(=O)C(C)(C)C
Show InChI InChI=1S/C30H34F3N7O3/c1-6-25(41)35-19-8-7-9-20(16-19)36-26-22(30(31,32)33)18-34-28(38-26)37-23-11-10-21(17-24(23)43-5)39-12-14-40(15-13-39)27(42)29(2,3)4/h6-11,16-18H,1,12-15H2,2-5H3,(H,35,41)(H2,34,36,37,38)
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n/an/a<1n/an/an/an/a7.5n/a



Celgene Avilomics Research, Inc.

US Patent


Assay Description
Briefly, 10x stocks of EGFR-WT (PV3872) from Invitrogen and EGFR-T790M/L858R (40350) from BPS Bioscience, San Diego, Calif., 1.13xATP (AS001A) and ap...

US Patent US8975249 (2015)


BindingDB Entry DOI: 10.7270/Q22V2DVS
More data for this
Ligand-Target Pair
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