Found 357 hits with Last Name = 'bednarek' and Initial = 'ma' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105879
(15-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O Show InChI InChI=1S/C54H71N15O9/c1-3-4-15-40(63-31(2)70)48(73)69-45-27-46(71)59-21-10-9-17-39(47(55)72)64-51(76)43(25-35-28-61-38-16-8-7-14-37(35)38)67-49(74)41(18-11-22-60-54(56)57)65-50(75)42(24-32-19-20-33-12-5-6-13-34(33)23-32)66-52(77)44(68-53(45)78)26-36-29-58-30-62-36/h5-8,12-14,16,19-20,23,28-30,39-45,61H,3-4,9-11,15,17-18,21-22,24-27H2,1-2H3,(H2,55,72)(H,58,62)(H,59,71)(H,63,70)(H,64,76)(H,65,75)(H,66,77)(H,67,74)(H,68,78)(H,69,73)(H4,56,57,60)/t39-,40+,41+,42+,43-,44+,45+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50105879
(15-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O Show InChI InChI=1S/C54H71N15O9/c1-3-4-15-40(63-31(2)70)48(73)69-45-27-46(71)59-21-10-9-17-39(47(55)72)64-51(76)43(25-35-28-61-38-16-8-7-14-37(35)38)67-49(74)41(18-11-22-60-54(56)57)65-50(75)42(24-32-19-20-33-12-5-6-13-34(33)23-32)66-52(77)44(68-53(45)78)26-36-29-58-30-62-36/h5-8,12-14,16,19-20,23,28-30,39-45,61H,3-4,9-11,15,17-18,21-22,24-27H2,1-2H3,(H2,55,72)(H,58,62)(H,59,71)(H,63,70)(H,64,76)(H,65,75)(H,66,77)(H,67,74)(H,68,78)(H,69,73)(H4,56,57,60)/t39-,40+,41+,42+,43-,44+,45+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105880
(15-Acetylamino-6-(3-guanidino-propyl)-12-(3H-imida...)Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O Show InChI InChI=1S/C48H60N14O8/c1-27(63)57-40-23-41(64)53-17-7-6-13-35(42(49)65)58-45(68)38(21-31-24-55-34-12-5-4-11-33(31)34)61-43(66)36(14-8-18-54-48(50)51)59-44(67)37(20-28-15-16-29-9-2-3-10-30(29)19-28)60-46(69)39(62-47(40)70)22-32-25-52-26-56-32/h2-5,9-12,15-16,19,24-26,35-40,55H,6-8,13-14,17-18,20-23H2,1H3,(H2,49,65)(H,52,56)(H,53,64)(H,57,63)(H,58,68)(H,59,67)(H,60,69)(H,61,66)(H,62,70)(H4,50,51,54)/t35-,36+,37-,38-,39+,40+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.0960 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85951
(hAc-MCH(6-16)-NH2)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-2-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C58H97N21O13S3/c1-30(2)25-39-47(84)69-27-44(82)71-36(12-8-21-67-57(62)63)50(87)78-45(31(3)4)54(91)75-40(26-33-15-17-34(81)18-16-33)51(88)73-38(13-9-22-68-58(64)65)55(92)79-23-10-14-43(79)53(90)76-41(46(59)83)28-94-95-29-42(52(89)72-37(19-24-93-6)49(86)74-39)77-48(85)35(70-32(5)80)11-7-20-66-56(60)61/h15-18,30-31,35-43,45,81H,7-14,19-29H2,1-6H3,(H2,59,83)(H,69,84)(H,70,80)(H,71,82)(H,72,89)(H,73,88)(H,74,86)(H,75,91)(H,76,90)(H,77,85)(H,78,87)(H4,60,61,66)(H4,62,63,67)(H4,64,65,68) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85788
(MCH | hMCH)Show SMILES CSCCC(NC(=O)C(CC(O)=O)NC(=O)C(Cc1ccccc1)NC(=O)C(N)CC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC1CSSCC(NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(NC(=O)C(CCCN=C(N)N)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CCSC)NC1=O)C(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCC(N)=O)C(=O)NC(C(C)C)C(O)=O |(16.32,9.48,;17.66,10.25,;18.99,9.48,;20.32,10.25,;21.66,9.48,;22.99,10.25,;22.99,11.79,;21.66,12.56,;24.33,12.56,;24.33,14.1,;23.24,15.19,;23.63,16.68,;21.75,14.79,;25.66,11.79,;26.99,12.56,;26.99,14.1,;28.33,11.79,;28.33,10.25,;29.66,9.48,;29.66,7.94,;30.99,7.17,;32.33,7.94,;32.33,9.48,;30.99,10.25,;29.66,12.56,;31.15,12.16,;31.55,10.67,;32.48,12.93,;33.81,12.16,;32.48,14.47,;33.81,15.24,;33.81,16.78,;35.3,14.84,;21.66,7.94,;22.99,7.17,;20.32,7.17,;20.32,5.63,;18.99,4.86,;18.99,3.32,;17.66,2.55,;20.32,2.55,;21.66,4.86,;22.99,5.63,;21.66,3.32,;22.99,2.55,;24.33,3.32,;24.33,4.86,;25.66,5.63,;25.66,7.17,;26.99,7.94,;26.99,9.48,;28.33,7.17,;22.99,1.01,;21.66,.24,;24.33,.24,;24.33,-1.3,;22.99,-2.07,;21.66,-1.3,;20.32,-2.07,;20.32,-3.61,;18.99,-4.38,;18.99,-5.92,;17.66,-6.69,;16.12,-6.69,;17.66,-8.23,;16.52,-9.26,;17.15,-10.66,;18.67,-10.5,;18.99,-9,;20.32,-8.23,;21.09,-6.9,;21.66,-9,;21.66,-10.54,;20.32,-11.31,;20.32,-12.85,;18.99,-13.62,;18.99,-15.16,;17.66,-15.93,;20.32,-15.93,;22.99,-8.23,;24.33,-9,;24.33,-10.54,;25.66,-8.23,;26.99,-9,;26.99,-10.54,;25.66,-11.31,;25.66,-12.85,;26.99,-13.62,;26.99,-15.16,;28.33,-12.85,;28.33,-11.31,;25.66,-6.69,;26.99,-5.92,;26.99,-4.38,;28.33,-6.69,;29.66,-5.92,;30.99,-6.69,;30.99,-8.23,;32.33,-5.92,;33.66,-6.69,;33.66,-8.23,;34.99,-9,;34.99,-10.54,;36.33,-11.31,;36.33,-12.85,;37.66,-10.54,;32.33,-4.38,;33.66,-3.61,;34.99,-4.38,;33.66,-2.07,;32.33,-1.3,;32.33,.24,;33.66,1.01,;30.99,1.01,;30.99,2.55,;32.33,3.32,;32.33,4.86,;33.66,2.55,;29.66,.24,;28.33,1.01,;28.33,2.55,;26.99,.24,;25.81,1.23,;26.08,2.75,;27.53,3.27,;27.8,4.79,;26.99,-1.3,;25.66,-2.07,;25.66,-3.61,;28.33,-8.23,;29.66,-9,;28.33,-9.77,;17.66,-3.61,;17.66,-2.07,;16.32,-4.38,;14.99,-3.61,;14.99,-2.07,;13.66,-1.3,;12.26,-1.93,;11.23,-.79,;11.99,.54,;11.51,2,;12.54,3.15,;14.05,2.83,;14.53,1.37,;13.5,.22,;13.66,-4.38,;13.66,-5.92,;12.12,-3.61,;10.78,-4.38,;10.78,-5.92,;9.45,-6.69,;9.45,-8.23,;8.11,-9,;10.78,-9,;9.45,-3.61,;9.45,-2.07,;7.91,-4.38,;6.57,-3.61,;6.57,-2.07,;5.24,-1.3,;7.91,-1.3,;5.24,-4.38,;3.91,-3.61,;5.24,-5.92,)| Show InChI InChI=1S/C105H160N30O26S4/c1-53(2)42-70-86(144)118-50-80(138)119-64(24-16-36-114-103(108)109)90(148)133-83(55(5)6)100(158)130-73(45-58-28-30-60(136)31-29-58)93(151)124-69(26-18-38-116-105(112)113)101(159)135-39-19-27-78(135)99(157)132-77(98(156)128-74(46-59-49-117-63-23-15-14-22-61(59)63)95(153)121-66(32-33-79(107)137)91(149)134-84(56(7)8)102(160)161)52-165-164-51-76(97(155)123-68(35-41-163-10)88(146)126-70)131-87(145)65(25-17-37-115-104(110)111)120-92(150)71(43-54(3)4)127-89(147)67(34-40-162-9)122-96(154)75(48-82(141)142)129-94(152)72(44-57-20-12-11-13-21-57)125-85(143)62(106)47-81(139)140/h11-15,20-23,28-31,49,53-56,62,64-78,83-84,117,136H,16-19,24-27,32-48,50-52,106H2,1-10H3,(H2,107,137)(H,118,144)(H,119,138)(H,120,150)(H,121,153)(H,122,154)(H,123,155)(H,124,151)(H,125,143)(H,126,146)(H,127,147)(H,128,156)(H,129,152)(H,130,158)(H,131,145)(H,132,157)(H,133,148)(H,134,149)(H,139,140)(H,141,142)(H,160,161)(H4,108,109,114)(H4,110,111,115)(H4,112,113,116) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50105879
(15-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O Show InChI InChI=1S/C54H71N15O9/c1-3-4-15-40(63-31(2)70)48(73)69-45-27-46(71)59-21-10-9-17-39(47(55)72)64-51(76)43(25-35-28-61-38-16-8-7-14-37(35)38)67-49(74)41(18-11-22-60-54(56)57)65-50(75)42(24-32-19-20-33-12-5-6-13-34(33)23-32)66-52(77)44(68-53(45)78)26-36-29-58-30-62-36/h5-8,12-14,16,19-20,23,28-30,39-45,61H,3-4,9-11,15,17-18,21-22,24-27H2,1-2H3,(H2,55,72)(H,58,62)(H,59,71)(H,63,70)(H,64,76)(H,65,75)(H,66,77)(H,67,74)(H,68,78)(H,69,73)(H4,56,57,60)/t39-,40+,41+,42+,43-,44+,45+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105893
(9-(3-Guanidino-propyl)-15-(3H-imidazol-4-ylmethyl)...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCC(NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C43H51N13O7/c44-38(59)35-22-50-36(57)13-14-37(58)52-34(19-28-21-47-23-51-28)42(63)54-32(17-24-11-12-25-6-1-2-7-26(25)16-24)40(61)53-31(10-5-15-48-43(45)46)39(60)55-33(41(62)56-35)18-27-20-49-30-9-4-3-8-29(27)30/h1-4,6-9,11-12,16,20-21,23,31-35,49H,5,10,13-15,17-19,22H2,(H2,44,59)(H,47,51)(H,50,57)(H,52,58)(H,53,61)(H,54,63)(H,55,60)(H,56,62)(H4,45,46,48)/t31-,32-,33+,34-,35?/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105892
(12-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O)C(N)=O Show InChI InChI=1S/C48H64N12O8/c1-3-4-15-36(55-28(2)61)43(64)60-40-26-41(62)52-21-10-9-17-35(42(49)63)56-46(67)39(25-32-27-54-34-16-8-7-14-33(32)34)59-44(65)37(18-11-22-53-48(50)51)57-45(66)38(58-47(40)68)24-29-19-20-30-12-5-6-13-31(30)23-29/h5-8,12-14,16,19-20,23,27,35-40,54H,3-4,9-11,15,17-18,21-22,24-26H2,1-2H3,(H2,49,63)(H,52,62)(H,55,61)(H,56,67)(H,57,66)(H,58,68)(H,59,65)(H,60,64)(H4,50,51,53)/t35-,36+,37+,38+,39-,40+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85976
(N-Me-Nle8)Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-1-[#7](-[#6])-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-2-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C60H101N21O13S2/c1-8-9-17-44-53(90)75-40(27-32(2)3)49(86)71-29-46(84)73-38(15-11-24-69-59(64)65)51(88)79-47(33(4)5)55(92)76-41(28-35-19-21-36(83)22-20-35)52(89)74-39(16-12-25-70-60(66)67)57(94)81-26-13-18-45(81)54(91)77-42(48(61)85)30-95-96-31-43(56(93)80(44)7)78-50(87)37(72-34(6)82)14-10-23-68-58(62)63/h19-22,32-33,37-45,47,83H,8-18,23-31H2,1-7H3,(H2,61,85)(H,71,86)(H,72,82)(H,73,84)(H,74,89)(H,75,90)(H,76,92)(H,77,91)(H,78,87)(H,79,88)(H4,62,63,68)(H4,64,65,69)(H4,66,67,70) | Reactome pathway
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| 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105889
(5-(3-Guanidino-propyl)-8-(1H-indol-3-ylmethyl)-2-n...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)CCC(=O)NCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C39H48N10O6/c40-35(52)29-11-5-17-43-33(50)15-16-34(51)46-31(20-23-13-14-24-7-1-2-8-25(24)19-23)37(54)48-30(12-6-18-44-39(41)42)36(53)49-32(38(55)47-29)21-26-22-45-28-10-4-3-9-27(26)28/h1-4,7-10,13-14,19,22,29-32,45H,5-6,11-12,15-18,20-21H2,(H2,40,52)(H,43,50)(H,46,51)(H,47,55)(H,48,54)(H,49,53)(H4,41,42,44)/t29-,30+,31+,32-/m1/s1 | PDB
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| 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50105883
(3-[25-Acetylamino-4-carbamoyl-13-(3-guanidino-prop...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(N)=O Show InChI InChI=1S/C51H63N15O11S2/c1-27(67)60-41-25-79-78-24-40(44(52)71)61-42(68)23-58-45(72)38(19-31-21-57-34-10-5-4-9-33(31)34)65-46(73)35(11-6-16-56-51(53)54)62-48(75)37(18-28-12-13-29-7-2-3-8-30(29)17-28)64-49(76)39(20-32-22-55-26-59-32)66-47(74)36(63-50(41)77)14-15-43(69)70/h2-5,7-10,12-13,17,21-22,26,35-41,57H,6,11,14-16,18-20,23-25H2,1H3,(H2,52,71)(H,55,59)(H,58,72)(H,60,67)(H,61,68)(H,62,75)(H,63,77)(H,64,76)(H,65,73)(H,66,74)(H,69,70)(H4,53,54,56)/t35-,36+,37-,38+,39-,40-,41+/m0/s1 | PDB
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| 0.390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105888
(6-(3-Guanidino-propyl)-3-(1H-indol-3-ylmethyl)-9-n...)Show SMILES NNC(=O)[C@H]1CCCCNC(=O)CCC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N1 Show InChI InChI=1S/C40H51N11O6/c41-40(42)45-19-7-13-30-36(54)50-33(22-27-23-46-29-11-4-3-10-28(27)29)38(56)49-31(39(57)51-43)12-5-6-18-44-34(52)16-17-35(53)47-32(37(55)48-30)21-24-14-15-25-8-1-2-9-26(25)20-24/h1-4,8-11,14-15,20,23,30-33,46H,5-7,12-13,16-19,21-22,43H2,(H,44,52)(H,47,53)(H,48,55)(H,49,56)(H,50,54)(H,51,57)(H4,41,42,45)/t30-,31+,32-,33+/m0/s1 | PDB
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| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85956
(N-Me-Arg11)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-2-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7](-[#6])-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C59H99N21O13S3/c1-31(2)26-39-48(85)70-28-45(83)79(6)43(14-10-23-69-59(65)66)53(90)78-46(32(3)4)55(92)75-40(27-34-16-18-35(82)19-17-34)51(88)73-38(13-9-22-68-58(63)64)56(93)80-24-11-15-44(80)54(91)76-41(47(60)84)29-95-96-30-42(52(89)72-37(20-25-94-7)50(87)74-39)77-49(86)36(71-33(5)81)12-8-21-67-57(61)62/h16-19,31-32,36-44,46,82H,8-15,20-30H2,1-7H3,(H2,60,84)(H,70,85)(H,71,81)(H,72,89)(H,73,88)(H,74,87)(H,75,92)(H,76,91)(H,77,86)(H,78,90)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69) | Reactome pathway
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| 0.550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105883
(3-[25-Acetylamino-4-carbamoyl-13-(3-guanidino-prop...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(N)=O Show InChI InChI=1S/C51H63N15O11S2/c1-27(67)60-41-25-79-78-24-40(44(52)71)61-42(68)23-58-45(72)38(19-31-21-57-34-10-5-4-9-33(31)34)65-46(73)35(11-6-16-56-51(53)54)62-48(75)37(18-28-12-13-29-7-2-3-8-30(29)17-28)64-49(76)39(20-32-22-55-26-59-32)66-47(74)36(63-50(41)77)14-15-43(69)70/h2-5,7-10,12-13,17,21-22,26,35-41,57H,6,11,14-16,18-20,23-25H2,1H3,(H2,52,71)(H,55,59)(H,58,72)(H,60,67)(H,61,68)(H,62,75)(H,63,77)(H,64,76)(H,65,73)(H,66,74)(H,69,70)(H4,53,54,56)/t35-,36+,37-,38+,39-,40-,41+/m0/s1 | PDB
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| 0.570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105891
(13-Ethyl-6-(3-guanidino-propyl)-3-(1H-indol-3-ylme...)Show SMILES CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CCCCNC1=O)C(N)=O Show InChI InChI=1S/C42H54N10O6/c1-2-26-23-36(53)49-34(21-25-16-17-27-10-3-4-11-28(27)20-25)40(57)51-33(15-9-19-47-42(44)45)39(56)52-35(22-29-24-48-31-13-6-5-12-30(29)31)41(58)50-32(37(43)54)14-7-8-18-46-38(26)55/h3-6,10-13,16-17,20,24,26,32-35,48H,2,7-9,14-15,18-19,21-23H2,1H3,(H2,43,54)(H,46,55)(H,49,53)(H,50,58)(H,51,57)(H,52,56)(H4,44,45,47)/t26?,32-,33+,34+,35-/m1/s1 | PDB
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| 0.580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105891
(13-Ethyl-6-(3-guanidino-propyl)-3-(1H-indol-3-ylme...)Show SMILES CCC1CC(=O)N[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CCCCNC1=O)C(N)=O Show InChI InChI=1S/C42H54N10O6/c1-2-26-23-36(53)49-34(21-25-16-17-27-10-3-4-11-28(27)20-25)40(57)51-33(15-9-19-47-42(44)45)39(56)52-35(22-29-24-48-31-13-6-5-12-30(29)31)41(58)50-32(37(43)54)14-7-8-18-46-38(26)55/h3-6,10-13,16-17,20,24,26,32-35,48H,2,7-9,14-15,18-19,21-23H2,1H3,(H2,43,54)(H,46,55)(H,49,53)(H,50,58)(H,51,57)(H,52,56)(H4,44,45,47)/t26?,32-,33+,34+,35-/m1/s1 | PDB
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| 0.580 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105894
(16-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](Cc2ccc3ccccc3c2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CCCCNC1=O)C(N)=O Show InChI InChI=1S/C54H71N15O9/c1-3-4-15-40(63-31(2)70)49(74)69-45-27-46(71)64-44(26-36-29-58-30-62-36)53(78)67-42(24-32-19-20-33-12-5-6-13-34(33)23-32)51(76)66-41(18-11-22-60-54(56)57)50(75)68-43(25-35-28-61-38-16-8-7-14-37(35)38)52(77)65-39(47(55)72)17-9-10-21-59-48(45)73/h5-8,12-14,16,19-20,23,28-30,39-45,61H,3-4,9-11,15,17-18,21-22,24-27H2,1-2H3,(H2,55,72)(H,58,62)(H,59,73)(H,63,70)(H,64,71)(H,65,77)(H,66,76)(H,67,78)(H,68,75)(H,69,74)(H4,56,57,60)/t39-,40+,41+,42-,43-,44+,45-/m1/s1 | PDB
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| 0.850 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105895
(6-(3-Guanidino-propyl)-12-(3H-imidazol-4-ylmethyl)...)Show SMILES NC(=N)NCCC[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(N)=O Show InChI InChI=1S/C46H57N13O7/c47-41(62)34-12-5-6-18-51-39(60)16-17-40(61)55-38(23-31-25-50-26-54-31)45(66)58-36(21-27-14-15-28-8-1-2-9-29(28)20-27)43(64)57-35(13-7-19-52-46(48)49)42(63)59-37(44(65)56-34)22-30-24-53-33-11-4-3-10-32(30)33/h1-4,8-11,14-15,20,24-26,34-38,53H,5-7,12-13,16-19,21-23H2,(H2,47,62)(H,50,54)(H,51,60)(H,55,61)(H,56,65)(H,57,64)(H,58,66)(H,59,63)(H4,48,49,52)/t34-,35+,36+,37-,38+/m1/s1 | PDB
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| 0.880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50105880
(15-Acetylamino-6-(3-guanidino-propyl)-12-(3H-imida...)Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O Show InChI InChI=1S/C48H60N14O8/c1-27(63)57-40-23-41(64)53-17-7-6-13-35(42(49)65)58-45(68)38(21-31-24-55-34-12-5-4-11-33(31)34)61-43(66)36(14-8-18-54-48(50)51)59-44(67)37(20-28-15-16-29-9-2-3-10-30(29)19-28)60-46(69)39(62-47(40)70)22-32-25-52-26-56-32/h2-5,9-12,15-16,19,24-26,35-40,55H,6-8,13-14,17-18,20-23H2,1H3,(H2,49,65)(H,52,56)(H,53,64)(H,57,63)(H,58,68)(H,59,67)(H,60,69)(H,61,66)(H,62,70)(H4,50,51,54)/t35-,36+,37-,38-,39+,40+/m1/s1 | PDB
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PC cid
PC sid
UniChem
Similars
| PubMed
| 0.960 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105887
(CHEMBL2370553 | Cyclo Ac-Cys-Glu-His-D-(2')Nal-Arg...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(O)=O |wU:82.89,89.97,4.3,57.61,42.44,101.109,31.33,wD:9.81,92.105,17.17,67.72,(.52,-47.48,;1.54,-48.63,;1.05,-50.09,;3.04,-48.33,;3.52,-46.86,;5.04,-47.18,;6.57,-47.12,;8.06,-46.67,;9.39,-45.91,;10.5,-44.85,;11.33,-43.55,;11.81,-42.09,;13.33,-42.39,;11.93,-40.55,;11.7,-39.03,;11.09,-37.61,;12.42,-36.84,;10.16,-36.38,;11.28,-35.31,;12.75,-35.73,;13.97,-34.79,;15.24,-35.66,;14.82,-37.14,;15.63,-38.45,;14.9,-39.8,;13.35,-39.85,;12.55,-38.55,;13.27,-37.19,;8.97,-35.4,;7.58,-34.74,;8.06,-33.28,;6.06,-34.43,;6.19,-32.89,;7.58,-32.24,;7.71,-30.7,;9.11,-30.04,;9.23,-28.5,;10.62,-27.84,;7.95,-27.63,;4.53,-34.5,;3.05,-34.91,;2.45,-33.51,;1.71,-35.7,;.79,-34.46,;.78,-32.93,;2.1,-32.14,;2.1,-30.61,;.75,-29.86,;.73,-28.32,;-.61,-27.57,;-1.93,-28.36,;-1.91,-29.88,;-.57,-30.65,;-.55,-32.17,;.61,-36.75,;-.23,-38.06,;-1.62,-37.41,;-.71,-39.53,;-2.23,-39.22,;-2.7,-37.76,;-1.81,-36.5,;-2.72,-35.26,;-4.18,-35.75,;-4.18,-37.29,;-.83,-41.06,;-.58,-42.58,;-2.06,-43.01,;.02,-44,;-1.32,-44.76,;-2.65,-44,;-3.98,-44.76,;-5.32,-44,;-3.98,-46.3,;.94,-45.23,;2.14,-46.21,;1.31,-47.5,;11.7,-45.81,;11.44,-47.34,;13.14,-45.28,;13.05,-43.74,;14.49,-43.2,;15.45,-44.39,;14.62,-45.67,;15.17,-47.12,;14.2,-48.3,;16.7,-47.35,;16.61,-45.81,;18.05,-45.25,;19.01,-46.46,;18.17,-47.75,;18.94,-49.07,;18.16,-50.4,;20.48,-49.07,;21.25,-47.75,;20.48,-46.41,;21.25,-45.08,;20.48,-43.74,;21.26,-42.41,;21.24,-50.4,;22.77,-50.4,;23.55,-49.07,;23.54,-51.74,;25.08,-51.75,;22.76,-53.05,;23.53,-54.41,;22.76,-55.73,;25.06,-54.41,)| Show InChI InChI=1S/C70H93N19O16S2/c1-38(90)80-53-35-106-107-36-54(68(104)89-26-10-18-56(89)69(105)88-25-9-17-55(88)60(96)47(15-6-7-23-71)82-61(97)45(72)31-59(94)95)81-57(91)34-78-62(98)51(29-42-32-77-46-14-5-4-13-44(42)46)86-63(99)48(16-8-24-76-70(73)74)83-65(101)50(28-39-19-20-40-11-2-3-12-41(40)27-39)85-66(102)52(30-43-33-75-37-79-43)87-64(100)49(84-67(53)103)21-22-58(92)93/h2-5,11-14,19-20,27,32-33,37,45,47-56,77H,6-10,15-18,21-26,28-31,34-36,71-72H2,1H3,(H,75,79)(H,78,98)(H,80,90)(H,81,91)(H,82,97)(H,83,101)(H,84,103)(H,85,102)(H,86,99)(H,87,100)(H,92,93)(H,94,95)(H4,73,74,76)/t45?,47?,48-,49+,50-,51+,52-,53+,54-,55?,56?/m0/s1 | PDB
KEGG
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PC sid
UniChem
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| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105876
(15-Amino-6-(3-guanidino-propyl)-12-(3H-imidazol-4-...)Show SMILES N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O Show InChI InChI=1S/C46H58N14O7/c47-32-22-39(61)52-16-6-5-12-34(40(48)62)56-44(66)37(20-29-23-54-33-11-4-3-10-31(29)33)60-42(64)35(13-7-17-53-46(49)50)57-43(65)36(19-26-14-15-27-8-1-2-9-28(27)18-26)59-45(67)38(58-41(32)63)21-30-24-51-25-55-30/h1-4,8-11,14-15,18,23-25,32,34-38,54H,5-7,12-13,16-17,19-22,47H2,(H2,48,62)(H,51,55)(H,52,61)(H,56,66)(H,57,65)(H,58,63)(H,59,67)(H,60,64)(H4,49,50,53)/t32-,34+,35-,36-,37+,38-/m0/s1 | PDB
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UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85954
(Ava14,15)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C52H87N17O12S3/c1-28(2)23-36-45(76)61-25-41(73)63-34(12-10-21-60-52(56)57)48(79)69-42(29(3)4)50(81)67-37(24-31-14-16-32(71)17-15-31)44(75)58-19-8-7-13-40(72)64-38(43(53)74)26-83-84-27-39(49(80)65-35(18-22-82-6)47(78)66-36)68-46(77)33(62-30(5)70)11-9-20-59-51(54)55/h14-17,28-29,33-39,42,71H,7-13,18-27H2,1-6H3,(H2,53,74)(H,58,75)(H,61,76)(H,62,70)(H,63,73)(H,64,72)(H,65,80)(H,66,78)(H,67,81)(H,68,77)(H,69,79)(H4,54,55,59)(H4,56,57,60) | Reactome pathway
KEGG
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| PC cid
PC sid
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| Article
PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105882
(CHEMBL2370533 | Cyclo Ac-Cys-Glu-His-D-Phe-(3,4-di...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(O)=O |wU:80.86,87.94,4.3,55.58,42.44,99.106,31.33,wD:9.78,90.102,17.17,65.69,(.52,-47.47,;1.54,-48.61,;1.05,-50.07,;3.03,-48.31,;3.52,-46.84,;5.04,-47.16,;6.57,-47.1,;8.05,-46.66,;9.39,-45.89,;10.5,-44.84,;11.32,-43.53,;11.81,-42.07,;13.32,-42.38,;11.93,-40.54,;11.69,-39.02,;11.09,-37.6,;12.42,-36.83,;10.16,-36.37,;11.27,-35.3,;12.74,-35.72,;13.97,-34.78,;15.23,-35.65,;14.81,-37.13,;15.63,-38.43,;14.9,-39.79,;13.35,-39.84,;12.55,-38.53,;13.27,-37.18,;8.97,-35.39,;7.57,-34.73,;8.06,-33.27,;6.06,-34.41,;6.19,-32.88,;7.57,-32.23,;7.71,-30.69,;9.1,-30.03,;9.23,-28.49,;10.62,-27.83,;7.95,-27.62,;4.52,-34.48,;3.05,-34.9,;2.45,-33.5,;1.71,-35.69,;.79,-34.45,;.78,-32.92,;2.1,-32.13,;2.1,-30.6,;.75,-29.85,;.73,-28.31,;-.57,-30.63,;-1.91,-29.87,;-.55,-32.16,;.61,-36.74,;-.22,-38.05,;-1.62,-37.39,;-.71,-39.51,;-2.23,-39.21,;-2.7,-37.74,;-1.81,-36.49,;-2.72,-35.25,;-4.18,-35.74,;-4.18,-37.28,;-.83,-41.05,;-.58,-42.56,;-2.06,-43,;.02,-43.98,;-1.32,-44.75,;-2.65,-43.98,;-3.98,-44.75,;-5.32,-43.98,;-3.98,-46.29,;.94,-45.22,;2.14,-46.19,;1.31,-47.49,;11.69,-45.8,;11.44,-47.33,;13.14,-45.26,;13.04,-43.73,;14.49,-43.18,;15.44,-44.38,;14.62,-45.66,;15.16,-47.1,;14.2,-48.29,;16.69,-47.33,;16.61,-45.8,;18.04,-45.24,;19,-46.44,;18.17,-47.73,;18.93,-49.06,;18.16,-50.38,;20.47,-49.06,;21.24,-47.73,;20.47,-46.39,;21.24,-45.07,;20.47,-43.73,;21.25,-42.4,;21.23,-50.38,;22.77,-50.38,;23.54,-49.06,;23.53,-51.73,;25.07,-51.73,;22.75,-53.04,;23.52,-54.39,;22.75,-55.71,;25.06,-54.39,)| Show InChI InChI=1S/C66H89Cl2N19O16S2/c1-34(88)78-49-31-104-105-32-50(64(102)87-22-8-14-52(87)65(103)86-21-7-13-51(86)56(94)43(11-4-5-19-69)80-57(95)41(70)27-55(92)93)79-53(89)30-76-58(96)47(25-36-28-75-42-10-3-2-9-38(36)42)84-59(97)44(12-6-20-74-66(71)72)81-61(99)46(24-35-15-16-39(67)40(68)23-35)83-62(100)48(26-37-29-73-33-77-37)85-60(98)45(82-63(49)101)17-18-54(90)91/h2-3,9-10,15-16,23,28-29,33,41,43-52,75H,4-8,11-14,17-22,24-27,30-32,69-70H2,1H3,(H,73,77)(H,76,96)(H,78,88)(H,79,89)(H,80,95)(H,81,99)(H,82,101)(H,83,100)(H,84,97)(H,85,98)(H,90,91)(H,92,93)(H4,71,72,74)/t41?,43?,44-,45+,46-,47+,48-,49+,50-,51?,52?/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50105882
(CHEMBL2370533 | Cyclo Ac-Cys-Glu-His-D-Phe-(3,4-di...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(O)=O |wU:80.86,87.94,4.3,55.58,42.44,99.106,31.33,wD:9.78,90.102,17.17,65.69,(.52,-47.47,;1.54,-48.61,;1.05,-50.07,;3.03,-48.31,;3.52,-46.84,;5.04,-47.16,;6.57,-47.1,;8.05,-46.66,;9.39,-45.89,;10.5,-44.84,;11.32,-43.53,;11.81,-42.07,;13.32,-42.38,;11.93,-40.54,;11.69,-39.02,;11.09,-37.6,;12.42,-36.83,;10.16,-36.37,;11.27,-35.3,;12.74,-35.72,;13.97,-34.78,;15.23,-35.65,;14.81,-37.13,;15.63,-38.43,;14.9,-39.79,;13.35,-39.84,;12.55,-38.53,;13.27,-37.18,;8.97,-35.39,;7.57,-34.73,;8.06,-33.27,;6.06,-34.41,;6.19,-32.88,;7.57,-32.23,;7.71,-30.69,;9.1,-30.03,;9.23,-28.49,;10.62,-27.83,;7.95,-27.62,;4.52,-34.48,;3.05,-34.9,;2.45,-33.5,;1.71,-35.69,;.79,-34.45,;.78,-32.92,;2.1,-32.13,;2.1,-30.6,;.75,-29.85,;.73,-28.31,;-.57,-30.63,;-1.91,-29.87,;-.55,-32.16,;.61,-36.74,;-.22,-38.05,;-1.62,-37.39,;-.71,-39.51,;-2.23,-39.21,;-2.7,-37.74,;-1.81,-36.49,;-2.72,-35.25,;-4.18,-35.74,;-4.18,-37.28,;-.83,-41.05,;-.58,-42.56,;-2.06,-43,;.02,-43.98,;-1.32,-44.75,;-2.65,-43.98,;-3.98,-44.75,;-5.32,-43.98,;-3.98,-46.29,;.94,-45.22,;2.14,-46.19,;1.31,-47.49,;11.69,-45.8,;11.44,-47.33,;13.14,-45.26,;13.04,-43.73,;14.49,-43.18,;15.44,-44.38,;14.62,-45.66,;15.16,-47.1,;14.2,-48.29,;16.69,-47.33,;16.61,-45.8,;18.04,-45.24,;19,-46.44,;18.17,-47.73,;18.93,-49.06,;18.16,-50.38,;20.47,-49.06,;21.24,-47.73,;20.47,-46.39,;21.24,-45.07,;20.47,-43.73,;21.25,-42.4,;21.23,-50.38,;22.77,-50.38,;23.54,-49.06,;23.53,-51.73,;25.07,-51.73,;22.75,-53.04,;23.52,-54.39,;22.75,-55.71,;25.06,-54.39,)| Show InChI InChI=1S/C66H89Cl2N19O16S2/c1-34(88)78-49-31-104-105-32-50(64(102)87-22-8-14-52(87)65(103)86-21-7-13-51(86)56(94)43(11-4-5-19-69)80-57(95)41(70)27-55(92)93)79-53(89)30-76-58(96)47(25-36-28-75-42-10-3-2-9-38(36)42)84-59(97)44(12-6-20-74-66(71)72)81-61(99)46(24-35-15-16-39(67)40(68)23-35)83-62(100)48(26-37-29-73-33-77-37)85-60(98)45(82-63(49)101)17-18-54(90)91/h2-3,9-10,15-16,23,28-29,33,41,43-52,75H,4-8,11-14,17-22,24-27,30-32,69-70H2,1H3,(H,73,77)(H,76,96)(H,78,88)(H,79,89)(H,80,95)(H,81,99)(H,82,101)(H,83,100)(H,84,97)(H,85,98)(H,90,91)(H,92,93)(H4,71,72,74)/t41?,43?,44-,45+,46-,47+,48-,49+,50-,51?,52?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50105883
(3-[25-Acetylamino-4-carbamoyl-13-(3-guanidino-prop...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(N)=O Show InChI InChI=1S/C51H63N15O11S2/c1-27(67)60-41-25-79-78-24-40(44(52)71)61-42(68)23-58-45(72)38(19-31-21-57-34-10-5-4-9-33(31)34)65-46(73)35(11-6-16-56-51(53)54)62-48(75)37(18-28-12-13-29-7-2-3-8-30(29)17-28)64-49(76)39(20-32-22-55-26-59-32)66-47(74)36(63-50(41)77)14-15-43(69)70/h2-5,7-10,12-13,17,21-22,26,35-41,57H,6,11,14-16,18-20,23-25H2,1H3,(H2,52,71)(H,55,59)(H,58,72)(H,60,67)(H,61,68)(H,62,75)(H,63,77)(H,64,76)(H,65,73)(H,66,74)(H,69,70)(H4,53,54,56)/t35-,36+,37-,38+,39-,40-,41+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 2
(Homo sapiens (Human)) | BDBM85951
(hAc-MCH(6-16)-NH2)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-2-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C58H97N21O13S3/c1-30(2)25-39-47(84)69-27-44(82)71-36(12-8-21-67-57(62)63)50(87)78-45(31(3)4)54(91)75-40(26-33-15-17-34(81)18-16-33)51(88)73-38(13-9-22-68-58(64)65)55(92)79-23-10-14-43(79)53(90)76-41(46(59)83)28-94-95-29-42(52(89)72-37(19-24-93-6)49(86)74-39)77-48(85)35(70-32(5)80)11-7-20-66-56(60)61/h15-18,30-31,35-43,45,81H,7-14,19-29H2,1-6H3,(H2,59,83)(H,69,84)(H,70,80)(H,71,82)(H,72,89)(H,73,88)(H,74,86)(H,75,91)(H,76,90)(H,77,85)(H,78,87)(H4,60,61,66)(H4,62,63,67)(H4,64,65,68) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 2
(Homo sapiens (Human)) | BDBM85788
(MCH | hMCH)Show SMILES CSCCC(NC(=O)C(CC(O)=O)NC(=O)C(Cc1ccccc1)NC(=O)C(N)CC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC1CSSCC(NC(=O)C2CCCN2C(=O)C(CCCN=C(N)N)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(NC(=O)C(CCCN=C(N)N)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CCSC)NC1=O)C(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CCC(N)=O)C(=O)NC(C(C)C)C(O)=O |(16.32,9.48,;17.66,10.25,;18.99,9.48,;20.32,10.25,;21.66,9.48,;22.99,10.25,;22.99,11.79,;21.66,12.56,;24.33,12.56,;24.33,14.1,;23.24,15.19,;23.63,16.68,;21.75,14.79,;25.66,11.79,;26.99,12.56,;26.99,14.1,;28.33,11.79,;28.33,10.25,;29.66,9.48,;29.66,7.94,;30.99,7.17,;32.33,7.94,;32.33,9.48,;30.99,10.25,;29.66,12.56,;31.15,12.16,;31.55,10.67,;32.48,12.93,;33.81,12.16,;32.48,14.47,;33.81,15.24,;33.81,16.78,;35.3,14.84,;21.66,7.94,;22.99,7.17,;20.32,7.17,;20.32,5.63,;18.99,4.86,;18.99,3.32,;17.66,2.55,;20.32,2.55,;21.66,4.86,;22.99,5.63,;21.66,3.32,;22.99,2.55,;24.33,3.32,;24.33,4.86,;25.66,5.63,;25.66,7.17,;26.99,7.94,;26.99,9.48,;28.33,7.17,;22.99,1.01,;21.66,.24,;24.33,.24,;24.33,-1.3,;22.99,-2.07,;21.66,-1.3,;20.32,-2.07,;20.32,-3.61,;18.99,-4.38,;18.99,-5.92,;17.66,-6.69,;16.12,-6.69,;17.66,-8.23,;16.52,-9.26,;17.15,-10.66,;18.67,-10.5,;18.99,-9,;20.32,-8.23,;21.09,-6.9,;21.66,-9,;21.66,-10.54,;20.32,-11.31,;20.32,-12.85,;18.99,-13.62,;18.99,-15.16,;17.66,-15.93,;20.32,-15.93,;22.99,-8.23,;24.33,-9,;24.33,-10.54,;25.66,-8.23,;26.99,-9,;26.99,-10.54,;25.66,-11.31,;25.66,-12.85,;26.99,-13.62,;26.99,-15.16,;28.33,-12.85,;28.33,-11.31,;25.66,-6.69,;26.99,-5.92,;26.99,-4.38,;28.33,-6.69,;29.66,-5.92,;30.99,-6.69,;30.99,-8.23,;32.33,-5.92,;33.66,-6.69,;33.66,-8.23,;34.99,-9,;34.99,-10.54,;36.33,-11.31,;36.33,-12.85,;37.66,-10.54,;32.33,-4.38,;33.66,-3.61,;34.99,-4.38,;33.66,-2.07,;32.33,-1.3,;32.33,.24,;33.66,1.01,;30.99,1.01,;30.99,2.55,;32.33,3.32,;32.33,4.86,;33.66,2.55,;29.66,.24,;28.33,1.01,;28.33,2.55,;26.99,.24,;25.81,1.23,;26.08,2.75,;27.53,3.27,;27.8,4.79,;26.99,-1.3,;25.66,-2.07,;25.66,-3.61,;28.33,-8.23,;29.66,-9,;28.33,-9.77,;17.66,-3.61,;17.66,-2.07,;16.32,-4.38,;14.99,-3.61,;14.99,-2.07,;13.66,-1.3,;12.26,-1.93,;11.23,-.79,;11.99,.54,;11.51,2,;12.54,3.15,;14.05,2.83,;14.53,1.37,;13.5,.22,;13.66,-4.38,;13.66,-5.92,;12.12,-3.61,;10.78,-4.38,;10.78,-5.92,;9.45,-6.69,;9.45,-8.23,;8.11,-9,;10.78,-9,;9.45,-3.61,;9.45,-2.07,;7.91,-4.38,;6.57,-3.61,;6.57,-2.07,;5.24,-1.3,;7.91,-1.3,;5.24,-4.38,;3.91,-3.61,;5.24,-5.92,)| Show InChI InChI=1S/C105H160N30O26S4/c1-53(2)42-70-86(144)118-50-80(138)119-64(24-16-36-114-103(108)109)90(148)133-83(55(5)6)100(158)130-73(45-58-28-30-60(136)31-29-58)93(151)124-69(26-18-38-116-105(112)113)101(159)135-39-19-27-78(135)99(157)132-77(98(156)128-74(46-59-49-117-63-23-15-14-22-61(59)63)95(153)121-66(32-33-79(107)137)91(149)134-84(56(7)8)102(160)161)52-165-164-51-76(97(155)123-68(35-41-163-10)88(146)126-70)131-87(145)65(25-17-37-115-104(110)111)120-92(150)71(43-54(3)4)127-89(147)67(34-40-162-9)122-96(154)75(48-82(141)142)129-94(152)72(44-57-20-12-11-13-21-57)125-85(143)62(106)47-81(139)140/h11-15,20-23,28-31,49,53-56,62,64-78,83-84,117,136H,16-19,24-27,32-48,50-52,106H2,1-10H3,(H2,107,137)(H,118,144)(H,119,138)(H,120,150)(H,121,153)(H,122,154)(H,123,155)(H,124,151)(H,125,143)(H,126,146)(H,127,147)(H,128,156)(H,129,152)(H,130,158)(H,131,145)(H,132,157)(H,133,148)(H,134,149)(H,139,140)(H,141,142)(H,160,161)(H4,108,109,114)(H4,110,111,115)(H4,112,113,116) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85961
(N-Me-Gly10)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-2-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6])-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C59H99N21O13S3/c1-31(2)26-41-55(92)79(6)28-45(83)71-37(13-9-22-68-58(63)64)50(87)78-46(32(3)4)54(91)74-40(27-34-16-18-35(82)19-17-34)51(88)73-39(14-10-23-69-59(65)66)56(93)80-24-11-15-44(80)53(90)76-42(47(60)84)29-95-96-30-43(52(89)72-38(20-25-94-7)49(86)75-41)77-48(85)36(70-33(5)81)12-8-21-67-57(61)62/h16-19,31-32,36-44,46,82H,8-15,20-30H2,1-7H3,(H2,60,84)(H,70,81)(H,71,83)(H,72,89)(H,73,88)(H,74,91)(H,75,86)(H,76,90)(H,77,85)(H,78,87)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105890
(12-Amino-6-(3-guanidino-propyl)-3-(1H-indol-3-ylme...)Show SMILES N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O)C(N)=O Show InChI InChI=1S/C40H51N11O6/c41-28-21-34(52)45-16-6-5-12-30(35(42)53)48-39(57)33(20-26-22-47-29-11-4-3-10-27(26)29)51-37(55)31(13-7-17-46-40(43)44)49-38(56)32(50-36(28)54)19-23-14-15-24-8-1-2-9-25(24)18-23/h1-4,8-11,14-15,18,22,28,30-33,47H,5-7,12-13,16-17,19-21,41H2,(H2,42,53)(H,45,52)(H,48,57)(H,49,56)(H,50,54)(H,51,55)(H4,43,44,46)/t28-,30+,31-,32-,33+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85965
(Ava9,10)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-2-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C55H92N20O12S3/c1-30(2)43-51(86)71-38(27-32-16-18-33(77)19-17-32)48(83)70-37(13-9-24-66-55(61)62)52(87)75-25-10-14-41(75)50(85)72-39(44(56)79)28-89-90-29-40(73-46(81)34(67-31(3)76)11-7-22-64-53(57)58)49(84)69-36(20-26-88-4)45(80)63-21-6-5-15-42(78)68-35(47(82)74-43)12-8-23-65-54(59)60/h16-19,30,34-41,43,77H,5-15,20-29H2,1-4H3,(H2,56,79)(H,63,80)(H,67,76)(H,68,78)(H,69,84)(H,70,83)(H,71,86)(H,72,85)(H,73,81)(H,74,82)(H4,57,58,64)(H4,59,60,65)(H4,61,62,66) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50105877
(12-Acetylamino-6-(3-guanidino-propyl)-3-(1H-indol-...)Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O)C(N)=O Show InChI InChI=1S/C42H53N11O7/c1-24(54)49-35-22-36(55)46-17-7-6-13-31(37(43)56)50-40(59)34(21-28-23-48-30-12-5-4-11-29(28)30)53-38(57)32(14-8-18-47-42(44)45)51-39(58)33(52-41(35)60)20-25-15-16-26-9-2-3-10-27(26)19-25/h2-5,9-12,15-16,19,23,31-35,48H,6-8,13-14,17-18,20-22H2,1H3,(H2,43,56)(H,46,55)(H,49,54)(H,50,59)(H,51,58)(H,52,60)(H,53,57)(H4,44,45,47)/t31-,32+,33+,34-,35+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50105880
(15-Acetylamino-6-(3-guanidino-propyl)-12-(3H-imida...)Show SMILES CC(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O Show InChI InChI=1S/C48H60N14O8/c1-27(63)57-40-23-41(64)53-17-7-6-13-35(42(49)65)58-45(68)38(21-31-24-55-34-12-5-4-11-33(31)34)61-43(66)36(14-8-18-54-48(50)51)59-44(67)37(20-28-15-16-29-9-2-3-10-30(29)19-28)60-46(69)39(62-47(40)70)22-32-25-52-26-56-32/h2-5,9-12,15-16,19,24-26,35-40,55H,6-8,13-14,17-18,20-23H2,1H3,(H2,49,65)(H,52,56)(H,53,64)(H,57,63)(H,58,68)(H,59,67)(H,60,69)(H,61,66)(H,62,70)(H4,50,51,54)/t35-,36+,37-,38-,39+,40+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 4.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85962
(Gva6,Nle8,Ava14,15)Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7] Show InChI InChI=1S/C51H86N16O11S2/c1-6-7-13-34-46(75)65-35(24-29(2)3)45(74)60-26-41(71)61-33(14-12-23-59-51(55)56)47(76)67-42(30(4)5)49(78)66-36(25-31-17-19-32(68)20-18-31)44(73)57-21-10-8-15-39(69)62-37(43(52)72)27-79-80-28-38(48(77)64-34)63-40(70)16-9-11-22-58-50(53)54/h17-20,29-30,33-38,42,68H,6-16,21-28H2,1-5H3,(H2,52,72)(H,57,73)(H,60,74)(H,61,71)(H,62,69)(H,63,70)(H,64,77)(H,65,75)(H,66,78)(H,67,76)(H4,53,54,58)(H4,55,56,59) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85948
(Gva6,Ava9,10)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-2-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7] Show InChI InChI=1S/C53H89N19O11S3/c1-30(2)42-49(82)69-36(27-31-16-18-32(73)19-17-31)46(79)68-35(12-9-24-64-53(59)60)50(83)72-25-10-13-39(72)48(81)70-37(43(54)76)28-85-86-29-38(66-41(75)15-5-7-22-62-51(55)56)47(80)67-34(20-26-84-3)44(77)61-21-6-4-14-40(74)65-33(45(78)71-42)11-8-23-63-52(57)58/h16-19,30,33-39,42,73H,4-15,20-29H2,1-3H3,(H2,54,76)(H,61,77)(H,65,74)(H,66,75)(H,67,80)(H,68,79)(H,69,82)(H,70,81)(H,71,78)(H4,55,56,62)(H4,57,58,63)(H4,59,60,64) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 2
(Homo sapiens (Human)) | BDBM85956
(N-Me-Arg11)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-2-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7](-[#6])-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C59H99N21O13S3/c1-31(2)26-39-48(85)70-28-45(83)79(6)43(14-10-23-69-59(65)66)53(90)78-46(32(3)4)55(92)75-40(27-34-16-18-35(82)19-17-34)51(88)73-38(13-9-22-68-58(63)64)56(93)80-24-11-15-44(80)54(91)76-41(47(60)84)29-95-96-30-42(52(89)72-37(20-25-94-7)50(87)74-39)77-49(86)36(71-33(5)81)12-8-21-67-57(61)62/h16-19,31-32,36-44,46,82H,8-15,20-30H2,1-7H3,(H2,60,84)(H,70,85)(H,71,81)(H,72,89)(H,73,88)(H,74,87)(H,75,92)(H,76,91)(H,77,86)(H,78,90)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85953
(D-Arg6,Ava9,10)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6@@H](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-2-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C55H92N20O12S3/c1-30(2)43-51(86)71-38(27-32-16-18-33(77)19-17-32)48(83)70-37(13-9-24-66-55(61)62)52(87)75-25-10-14-41(75)50(85)72-39(44(56)79)28-89-90-29-40(73-46(81)34(67-31(3)76)11-7-22-64-53(57)58)49(84)69-36(20-26-88-4)45(80)63-21-6-5-15-42(78)68-35(47(82)74-43)12-8-23-65-54(59)60/h16-19,30,34-41,43,77H,5-15,20-29H2,1-4H3,(H2,56,79)(H,63,80)(H,67,76)(H,68,78)(H,69,84)(H,70,83)(H,71,86)(H,72,85)(H,73,81)(H,74,82)(H4,57,58,64)(H4,59,60,65)(H4,61,62,66)/t34?,35?,36?,37?,38?,39?,40-,41?,43?/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85975
(Gbu6,Ava14,15)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] Show InChI InChI=1S/C49H82N16O11S3/c1-27(2)22-33-43(72)58-24-39(69)59-31(10-8-19-56-48(51)52)45(74)65-40(28(3)4)47(76)64-34(23-29-13-15-30(66)16-14-29)42(71)55-18-7-6-11-37(67)60-35(41(50)70)25-78-79-26-36(61-38(68)12-9-20-57-49(53)54)46(75)62-32(17-21-77-5)44(73)63-33/h13-16,27-28,31-36,40,66H,6-12,17-26H2,1-5H3,(H2,50,70)(H,55,71)(H,58,72)(H,59,69)(H,60,67)(H,61,68)(H,62,75)(H,63,73)(H,64,76)(H,65,74)(H4,51,52,56)(H4,53,54,57) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85959
(Gva6,cisAcx14,15)Show SMILES [#6]-[#6]-[#6]-1-[#6]-[#6]-[#6]-[#6](=O)-[#7]-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6](-[#6]-[#6]-[#16]-[#6])-[#6](=O)-[#7]-[#6](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6](-[#6]-c2ccc(-[#8])cc2)-[#6](=O)-[#7]-1)-[#6](-[#7])=O Show InChI InChI=1S/C52H88N16O11S3/c1-7-32-12-10-15-41(71)63-38(44(53)73)27-81-82-28-39(64-40(70)14-8-9-21-58-51(54)55)49(78)65-35(20-23-80-6)46(75)66-36(24-29(2)3)45(74)60-26-42(72)62-34(13-11-22-59-52(56)57)47(76)68-43(30(4)5)50(79)67-37(48(77)61-32)25-31-16-18-33(69)19-17-31/h16-19,29-30,32,34-39,43,69H,7-15,20-28H2,1-6H3,(H2,53,73)(H,60,74)(H,61,77)(H,62,72)(H,63,71)(H,64,70)(H,65,78)(H,66,75)(H,67,79)(H,68,76)(H4,54,55,58)(H4,56,57,59) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85955
(D-Arg6,Ava14,15)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6@@H](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C52H87N17O12S3/c1-28(2)23-36-45(76)61-25-41(73)63-34(12-10-21-60-52(56)57)48(79)69-42(29(3)4)50(81)67-37(24-31-14-16-32(71)17-15-31)44(75)58-19-8-7-13-40(72)64-38(43(53)74)26-83-84-27-39(49(80)65-35(18-22-82-6)47(78)66-36)68-46(77)33(62-30(5)70)11-9-20-59-51(54)55/h14-17,28-29,33-39,42,71H,7-13,18-27H2,1-6H3,(H2,53,74)(H,58,75)(H,61,76)(H,62,70)(H,63,73)(H,64,72)(H,65,80)(H,66,78)(H,67,81)(H,68,77)(H,69,79)(H4,54,55,59)(H4,56,57,60)/t33?,34?,35?,36?,37?,38?,39-,42?/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 11.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50105876
(15-Amino-6-(3-guanidino-propyl)-12-(3H-imidazol-4-...)Show SMILES N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O Show InChI InChI=1S/C46H58N14O7/c47-32-22-39(61)52-16-6-5-12-34(40(48)62)56-44(66)37(20-29-23-54-33-11-4-3-10-31(29)33)60-42(64)35(13-7-17-53-46(49)50)57-43(65)36(19-26-14-15-27-8-1-2-9-28(27)18-26)59-45(67)38(58-41(32)63)21-30-24-51-25-55-30/h1-4,8-11,14-15,18,23-25,32,34-38,54H,5-7,12-13,16-17,19-22,47H2,(H2,48,62)(H,51,55)(H,52,61)(H,56,66)(H,57,65)(H,58,63)(H,59,67)(H,60,64)(H4,49,50,53)/t32-,34+,35-,36-,37+,38-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM85947
(Gva6,Ava14,15 | Gva6,betaAla14,15)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7] Show InChI InChI=1S/C50H84N16O11S3/c1-28(2)23-34-44(73)59-25-40(70)60-32(11-10-21-58-50(54)55)46(75)66-41(29(3)4)48(77)65-35(24-30-14-16-31(67)17-15-30)43(72)56-19-8-6-12-38(68)61-36(42(51)71)26-79-80-27-37(62-39(69)13-7-9-20-57-49(52)53)47(76)63-33(18-22-78-5)45(74)64-34/h14-17,28-29,32-37,41,67H,6-13,18-27H2,1-5H3,(H2,51,71)(H,56,72)(H,59,73)(H,60,70)(H,61,68)(H,62,69)(H,63,76)(H,64,74)(H,65,77)(H,66,75)(H4,52,53,57)(H4,54,55,58) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50105887
(CHEMBL2370553 | Cyclo Ac-Cys-Glu-His-D-(2')Nal-Arg...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(O)=O |wU:82.89,89.97,4.3,57.61,42.44,101.109,31.33,wD:9.81,92.105,17.17,67.72,(.52,-47.48,;1.54,-48.63,;1.05,-50.09,;3.04,-48.33,;3.52,-46.86,;5.04,-47.18,;6.57,-47.12,;8.06,-46.67,;9.39,-45.91,;10.5,-44.85,;11.33,-43.55,;11.81,-42.09,;13.33,-42.39,;11.93,-40.55,;11.7,-39.03,;11.09,-37.61,;12.42,-36.84,;10.16,-36.38,;11.28,-35.31,;12.75,-35.73,;13.97,-34.79,;15.24,-35.66,;14.82,-37.14,;15.63,-38.45,;14.9,-39.8,;13.35,-39.85,;12.55,-38.55,;13.27,-37.19,;8.97,-35.4,;7.58,-34.74,;8.06,-33.28,;6.06,-34.43,;6.19,-32.89,;7.58,-32.24,;7.71,-30.7,;9.11,-30.04,;9.23,-28.5,;10.62,-27.84,;7.95,-27.63,;4.53,-34.5,;3.05,-34.91,;2.45,-33.51,;1.71,-35.7,;.79,-34.46,;.78,-32.93,;2.1,-32.14,;2.1,-30.61,;.75,-29.86,;.73,-28.32,;-.61,-27.57,;-1.93,-28.36,;-1.91,-29.88,;-.57,-30.65,;-.55,-32.17,;.61,-36.75,;-.23,-38.06,;-1.62,-37.41,;-.71,-39.53,;-2.23,-39.22,;-2.7,-37.76,;-1.81,-36.5,;-2.72,-35.26,;-4.18,-35.75,;-4.18,-37.29,;-.83,-41.06,;-.58,-42.58,;-2.06,-43.01,;.02,-44,;-1.32,-44.76,;-2.65,-44,;-3.98,-44.76,;-5.32,-44,;-3.98,-46.3,;.94,-45.23,;2.14,-46.21,;1.31,-47.5,;11.7,-45.81,;11.44,-47.34,;13.14,-45.28,;13.05,-43.74,;14.49,-43.2,;15.45,-44.39,;14.62,-45.67,;15.17,-47.12,;14.2,-48.3,;16.7,-47.35,;16.61,-45.81,;18.05,-45.25,;19.01,-46.46,;18.17,-47.75,;18.94,-49.07,;18.16,-50.4,;20.48,-49.07,;21.25,-47.75,;20.48,-46.41,;21.25,-45.08,;20.48,-43.74,;21.26,-42.41,;21.24,-50.4,;22.77,-50.4,;23.55,-49.07,;23.54,-51.74,;25.08,-51.75,;22.76,-53.05,;23.53,-54.41,;22.76,-55.73,;25.06,-54.41,)| Show InChI InChI=1S/C70H93N19O16S2/c1-38(90)80-53-35-106-107-36-54(68(104)89-26-10-18-56(89)69(105)88-25-9-17-55(88)60(96)47(15-6-7-23-71)82-61(97)45(72)31-59(94)95)81-57(91)34-78-62(98)51(29-42-32-77-46-14-5-4-13-44(42)46)86-63(99)48(16-8-24-76-70(73)74)83-65(101)50(28-39-19-20-40-11-2-3-12-41(40)27-39)85-66(102)52(30-43-33-75-37-79-43)87-64(100)49(84-67(53)103)21-22-58(92)93/h2-5,11-14,19-20,27,32-33,37,45,47-56,77H,6-10,15-18,21-26,28-31,34-36,71-72H2,1H3,(H,75,79)(H,78,98)(H,80,90)(H,81,91)(H,82,97)(H,83,101)(H,84,103)(H,85,102)(H,86,99)(H,87,100)(H,92,93)(H,94,95)(H4,73,74,76)/t45?,47?,48-,49+,50-,51+,52-,53+,54-,55?,56?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 2
(Homo sapiens (Human)) | BDBM85976
(N-Me-Nle8)Show SMILES [#6]-[#6]-[#6]-[#6]-[#6]-1-[#7](-[#6])-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-2-[#6]-[#6]-[#6]-[#7]-2-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C60H101N21O13S2/c1-8-9-17-44-53(90)75-40(27-32(2)3)49(86)71-29-46(84)73-38(15-11-24-69-59(64)65)51(88)79-47(33(4)5)55(92)76-41(28-35-19-21-36(83)22-20-35)52(89)74-39(16-12-25-70-60(66)67)57(94)81-26-13-18-45(81)54(91)77-42(48(61)85)30-95-96-31-43(56(93)80(44)7)78-50(87)37(72-34(6)82)14-10-23-68-58(62)63/h19-22,32-33,37-45,47,83H,8-18,23-31H2,1-7H3,(H2,61,85)(H,71,86)(H,72,82)(H,73,84)(H,74,89)(H,75,90)(H,76,92)(H,77,91)(H,78,87)(H,79,88)(H4,62,63,68)(H4,64,65,69)(H4,66,67,70) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50105876
(15-Amino-6-(3-guanidino-propyl)-12-(3H-imidazol-4-...)Show SMILES N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O Show InChI InChI=1S/C46H58N14O7/c47-32-22-39(61)52-16-6-5-12-34(40(48)62)56-44(66)37(20-29-23-54-33-11-4-3-10-31(29)33)60-42(64)35(13-7-17-53-46(49)50)57-43(65)36(19-26-14-15-27-8-1-2-9-28(27)18-26)59-45(67)38(58-41(32)63)21-30-24-51-25-55-30/h1-4,8-11,14-15,18,23-25,32,34-38,54H,5-7,12-13,16-17,19-22,47H2,(H2,48,62)(H,51,55)(H,52,61)(H,56,66)(H,57,65)(H,58,63)(H,59,67)(H,60,64)(H4,49,50,53)/t32-,34+,35-,36-,37+,38-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50105892
(12-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O)C(N)=O Show InChI InChI=1S/C48H64N12O8/c1-3-4-15-36(55-28(2)61)43(64)60-40-26-41(62)52-21-10-9-17-35(42(49)63)56-46(67)39(25-32-27-54-34-16-8-7-14-33(32)34)59-44(65)37(18-11-22-53-48(50)51)57-45(66)38(58-47(40)68)24-29-19-20-30-12-5-6-13-31(30)23-29/h5-8,12-14,16,19-20,23,27,35-40,54H,3-4,9-11,15,17-18,21-22,24-26H2,1-2H3,(H2,49,63)(H,52,62)(H,55,61)(H,56,67)(H,57,66)(H,58,68)(H,59,65)(H,60,64)(H4,50,51,53)/t35-,36+,37+,38+,39-,40+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 2
(Homo sapiens (Human)) | BDBM85972
(Gva6,desLeu9,Ava14,15)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7] Show InChI InChI=1S/C44H73N15O10S3/c1-25(2)36-42(69)58-30(21-26-12-14-27(60)15-13-26)39(66)50-17-6-4-10-33(61)55-31(37(45)64)23-71-72-24-32(56-34(62)11-5-7-18-51-43(46)47)41(68)57-29(16-20-70-3)38(65)53-22-35(63)54-28(40(67)59-36)9-8-19-52-44(48)49/h12-15,25,28-32,36,60H,4-11,16-24H2,1-3H3,(H2,45,64)(H,50,66)(H,53,65)(H,54,63)(H,55,61)(H,56,62)(H,57,68)(H,58,69)(H,59,67)(H4,46,47,51)(H4,48,49,52) | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 2
(Homo sapiens (Human)) | BDBM85950
(D-Cys7,Ava14,15)Show SMILES [#6]-[#16]-[#6]-[#6]-[#6]-1-[#7]-[#6](=O)-[#6@@H](-[#6]-[#16]-[#16]-[#6]-[#6](-[#7]-[#6](=O)-[#6]-[#6]-[#6]-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6](=O)-[#6](-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6](-[#6]-[#6](-[#6])-[#6])-[#7]-[#6]-1=O)-[#6](-[#6])-[#6])-[#6](-[#7])=O)-[#7]-[#6](=O)-[#6](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](-[#6])=O Show InChI InChI=1S/C56H96N20O12S3/c1-30(2)25-39-47(82)67-27-44(80)70-37(14-10-23-66-56(62)63)50(85)76-45(31(3)4)53(88)74-40(26-33-16-18-35(78)19-17-33)51(86)69-34(12-8-21-64-54(58)59)11-7-15-43(79)71-41(46(57)81)28-90-91-29-42(52(87)72-38(20-24-89-6)49(84)73-39)75-48(83)36(68-32(5)77)13-9-22-65-55(60)61/h16-19,30-31,34,36-42,45,78H,7-15,20-29H2,1-6H3,(H2,57,81)(H,67,82)(H,68,77)(H,69,86)(H,70,80)(H,71,79)(H,72,87)(H,73,84)(H,74,88)(H,75,83)(H,76,85)(H4,58,59,64)(H4,60,61,65)(H4,62,63,66)/t34?,36?,37?,38?,39?,40?,41?,42-,45?/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by PDSP Ki Database
| |
Biochemistry 41: 6383-90 (2002)
Article DOI: 10.1021/bi0200514
BindingDB Entry DOI: 10.7270/Q23N21ZT |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Homo sapiens (Human)) | BDBM50105892
(12-(2-Acetylamino-hexanoylamino)-6-(3-guanidino-pr...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccc3ccccc3c2)NC1=O)C(N)=O Show InChI InChI=1S/C48H64N12O8/c1-3-4-15-36(55-28(2)61)43(64)60-40-26-41(62)52-21-10-9-17-35(42(49)63)56-46(67)39(25-32-27-54-34-16-8-7-14-33(32)34)59-44(65)37(18-11-22-53-48(50)51)57-45(66)38(58-47(40)68)24-29-19-20-30-12-5-6-13-31(30)23-29/h5-8,12-14,16,19-20,23,27,35-40,54H,3-4,9-11,15,17-18,21-22,24-26H2,1-2H3,(H2,49,63)(H,52,62)(H,55,61)(H,56,67)(H,57,66)(H,58,68)(H,59,65)(H,60,64)(H4,50,51,53)/t35-,36+,37+,38+,39-,40+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 5 (hMC5R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50105882
(CHEMBL2370533 | Cyclo Ac-Cys-Glu-His-D-Phe-(3,4-di...)Show SMILES CC(=O)N[C@@H]1CSSC[C@H](NC(=O)CNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](CCC(O)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(O)=O |wU:80.86,87.94,4.3,55.58,42.44,99.106,31.33,wD:9.78,90.102,17.17,65.69,(.52,-47.47,;1.54,-48.61,;1.05,-50.07,;3.03,-48.31,;3.52,-46.84,;5.04,-47.16,;6.57,-47.1,;8.05,-46.66,;9.39,-45.89,;10.5,-44.84,;11.32,-43.53,;11.81,-42.07,;13.32,-42.38,;11.93,-40.54,;11.69,-39.02,;11.09,-37.6,;12.42,-36.83,;10.16,-36.37,;11.27,-35.3,;12.74,-35.72,;13.97,-34.78,;15.23,-35.65,;14.81,-37.13,;15.63,-38.43,;14.9,-39.79,;13.35,-39.84,;12.55,-38.53,;13.27,-37.18,;8.97,-35.39,;7.57,-34.73,;8.06,-33.27,;6.06,-34.41,;6.19,-32.88,;7.57,-32.23,;7.71,-30.69,;9.1,-30.03,;9.23,-28.49,;10.62,-27.83,;7.95,-27.62,;4.52,-34.48,;3.05,-34.9,;2.45,-33.5,;1.71,-35.69,;.79,-34.45,;.78,-32.92,;2.1,-32.13,;2.1,-30.6,;.75,-29.85,;.73,-28.31,;-.57,-30.63,;-1.91,-29.87,;-.55,-32.16,;.61,-36.74,;-.22,-38.05,;-1.62,-37.39,;-.71,-39.51,;-2.23,-39.21,;-2.7,-37.74,;-1.81,-36.49,;-2.72,-35.25,;-4.18,-35.74,;-4.18,-37.28,;-.83,-41.05,;-.58,-42.56,;-2.06,-43,;.02,-43.98,;-1.32,-44.75,;-2.65,-43.98,;-3.98,-44.75,;-5.32,-43.98,;-3.98,-46.29,;.94,-45.22,;2.14,-46.19,;1.31,-47.49,;11.69,-45.8,;11.44,-47.33,;13.14,-45.26,;13.04,-43.73,;14.49,-43.18,;15.44,-44.38,;14.62,-45.66,;15.16,-47.1,;14.2,-48.29,;16.69,-47.33,;16.61,-45.8,;18.04,-45.24,;19,-46.44,;18.17,-47.73,;18.93,-49.06,;18.16,-50.38,;20.47,-49.06,;21.24,-47.73,;20.47,-46.39,;21.24,-45.07,;20.47,-43.73,;21.25,-42.4,;21.23,-50.38,;22.77,-50.38,;23.54,-49.06,;23.53,-51.73,;25.07,-51.73,;22.75,-53.04,;23.52,-54.39,;22.75,-55.71,;25.06,-54.39,)| Show InChI InChI=1S/C66H89Cl2N19O16S2/c1-34(88)78-49-31-104-105-32-50(64(102)87-22-8-14-52(87)65(103)86-21-7-13-51(86)56(94)43(11-4-5-19-69)80-57(95)41(70)27-55(92)93)79-53(89)30-76-58(96)47(25-36-28-75-42-10-3-2-9-38(36)42)84-59(97)44(12-6-20-74-66(71)72)81-61(99)46(24-35-15-16-39(67)40(68)23-35)83-62(100)48(26-37-29-73-33-77-37)85-60(98)45(82-63(49)101)17-18-54(90)91/h2-3,9-10,15-16,23,28-29,33,41,43-52,75H,4-8,11-14,17-22,24-27,30-32,69-70H2,1H3,(H,73,77)(H,76,96)(H,78,88)(H,79,89)(H,80,95)(H,81,99)(H,82,101)(H,83,100)(H,84,97)(H,85,98)(H,90,91)(H,92,93)(H4,71,72,74)/t41?,43?,44-,45+,46-,47+,48-,49+,50-,51?,52?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
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Similars
| PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 3 (hMC3R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50033134
((3R,6S,9R,12S,15S,23R)-15-((S)-2-Acetylamino-hexan...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O Show InChI InChI=1S/C54H71N15O9/c1-3-4-15-40(63-31(2)70)48(73)69-45-27-46(71)59-21-10-9-17-39(47(55)72)64-51(76)43(25-35-28-61-38-16-8-7-14-37(35)38)67-49(74)41(18-11-22-60-54(56)57)65-50(75)42(24-32-19-20-33-12-5-6-13-34(33)23-32)66-52(77)44(68-53(45)78)26-36-29-58-30-62-36/h5-8,12-14,16,19-20,23,28-30,39-45,61H,3-4,9-11,15,17-18,21-22,24-27H2,1-2H3,(H2,55,72)(H,58,62)(H,59,71)(H,63,70)(H,64,76)(H,65,75)(H,66,77)(H,67,74)(H,68,78)(H,69,73)(H4,56,57,60)/t39-,40+,41+,42-,43-,44+,45+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity against human melanocortin receptor 4 (hMC4R) (concentration of the peptide at 50% specific binding) |
J Med Chem 44: 3665-72 (2001)
BindingDB Entry DOI: 10.7270/Q2RF5T9S |
More data for this
Ligand-Target Pair | |
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