Compile Data Set for Download or QSAR

Found 69 hits with Last Name = 'bose' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50315887 ((1s,3s)-3-(8-amino-1-(2-phenylquinolin-7-yl)imidaz...) Show SMILES C[C@@]1(O)C[C@@H](C1)c1nc(-c2ccc3ccc(nc3c2)-c2ccccc2)c2c(N)nccn12 |r,wU:1.1,4.6,wD:1.0,(18.42,-37.26,;17.1,-36.49,;16.31,-37.82,;17.79,-35.11,;16.41,-34.42,;15.72,-35.8,;15.93,-32.97,;16.83,-31.71,;15.91,-30.47,;16.38,-29.01,;15.35,-27.88,;15.81,-26.41,;17.32,-26.08,;17.78,-24.62,;19.27,-24.29,;20.31,-25.42,;19.85,-26.89,;18.35,-27.21,;17.89,-28.68,;21.81,-25.09,;22.85,-26.23,;24.35,-25.9,;24.82,-24.43,;23.77,-23.29,;22.27,-23.63,;14.45,-30.96,;13.11,-30.19,;13.11,-28.65,;11.78,-30.96,;11.78,-32.51,;13.12,-33.28,;14.46,-32.5,)| Show InChI InChI=1S/C26H23N5O/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16/h2-13,19,32H,14-15H2,1H3,(H2,27,28)/t19-,26+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071033 (CHEMBL3409721) Show SMILES C1CC1c1cc(Nc2nc(nc3CCCc23)N2CCCCCC2)n[nH]1 Show InChI InChI=1S/C19H26N6/c1-2-4-11-25(10-3-1)19-20-15-7-5-6-14(15)18(22-19)21-17-12-16(23-24-17)13-8-9-13/h12-13H,1-11H2,(H2,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005651 (CHEMBL3235427) Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1ncc(s1)-c1ccc(NC(=O)Nc2ccccc2F)cc1 |r,wU:6.9,wD:3.2,(47.51,-36.67,;46.7,-37.98,;47.43,-39.33,;45.16,-37.93,;44.43,-36.57,;42.89,-36.52,;42.09,-37.83,;42.81,-39.19,;44.35,-39.24,;40.55,-37.79,;39.74,-39.1,;40.47,-40.46,;38.2,-39.06,;37.33,-37.79,;35.85,-38.22,;35.81,-39.76,;37.26,-40.28,;34.54,-40.64,;33.21,-39.88,;31.88,-40.65,;31.88,-42.19,;30.54,-42.96,;29.21,-42.19,;29.21,-40.65,;27.87,-42.96,;26.54,-42.19,;26.55,-40.64,;25.22,-39.87,;23.88,-40.64,;23.89,-42.19,;25.22,-42.95,;25.22,-44.49,;33.21,-42.96,;34.55,-42.19,)| Show InChI InChI=1S/C24H23FN4O4S/c25-18-3-1-2-4-19(18)29-24(33)28-17-9-5-14(6-10-17)20-13-26-22(34-20)21(30)27-16-11-7-15(8-12-16)23(31)32/h1-6,9-10,13,15-16H,7-8,11-12H2,(H,27,30)(H,31,32)(H2,28,29,33)/t15-,16-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
VIT University Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using 1,2-diacylglycerol/[14C]-oleoyl CoA as substrate assessed as [14C]-triglyceride formation after 10 mins by scintillat...				Eur J Med Chem 79: 203-15 (2014) Article DOI: 10.1016/j.ejmech.2014.03.077 BindingDB Entry DOI: 10.7270/Q23R0VCD
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005652 (CHEMBL3235428) Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1ncc(s1)-c1ccc(NC(=O)Nc2ccccc2Cl)cc1 |r,wU:6.9,wD:3.2,(70.47,-38.11,;69.66,-39.41,;70.39,-40.77,;68.12,-39.37,;67.39,-38.01,;65.84,-37.96,;65.05,-39.27,;65.77,-40.63,;67.3,-40.67,;63.51,-39.23,;62.7,-40.54,;63.43,-41.9,;61.16,-40.5,;60.29,-39.23,;58.81,-39.66,;58.77,-41.2,;60.22,-41.72,;57.5,-42.08,;56.17,-41.31,;54.84,-42.08,;54.83,-43.63,;53.5,-44.4,;52.17,-43.63,;52.17,-42.09,;50.83,-44.4,;49.5,-43.62,;49.51,-42.08,;48.18,-41.31,;46.84,-42.08,;46.85,-43.63,;48.18,-44.39,;48.18,-45.93,;56.17,-44.4,;57.51,-43.63,)| Show InChI InChI=1S/C24H23ClN4O4S/c25-18-3-1-2-4-19(18)29-24(33)28-17-9-5-14(6-10-17)20-13-26-22(34-20)21(30)27-16-11-7-15(8-12-16)23(31)32/h1-6,9-10,13,15-16H,7-8,11-12H2,(H,27,30)(H,31,32)(H2,28,29,33)/t15-,16-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
VIT University Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using 1,2-diacylglycerol/[14C]-oleoyl CoA as substrate assessed as [14C]-triglyceride formation after 10 mins by scintillat...				Eur J Med Chem 79: 203-15 (2014) Article DOI: 10.1016/j.ejmech.2014.03.077 BindingDB Entry DOI: 10.7270/Q23R0VCD
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071014 (CHEMBL3409716) Show SMILES CC1CCN(CC1)c1nc2CCCc2c(Nc2cc([nH]n2)C2CC2)n1 Show InChI InChI=1S/C19H26N6/c1-12-7-9-25(10-8-12)19-20-15-4-2-3-14(15)18(22-19)21-17-11-16(23-24-17)13-5-6-13/h11-13H,2-10H2,1H3,(H2,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005654 (CHEMBL3235430) Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1ncc(s1)-c1ccc(NC(=O)Nc2cc(F)c(F)cc2F)cc1 |r,wU:6.9,wD:3.2,(48.29,-50.11,;47.48,-51.42,;48.2,-52.78,;45.94,-51.37,;45.21,-50.02,;43.66,-49.97,;42.86,-51.28,;43.59,-52.64,;45.12,-52.68,;41.33,-51.24,;40.52,-52.55,;41.25,-53.9,;38.98,-52.51,;38.11,-51.24,;36.63,-51.67,;36.59,-53.21,;38.04,-53.73,;35.32,-54.09,;33.98,-53.32,;32.66,-54.09,;32.65,-55.64,;31.32,-56.41,;29.99,-55.64,;29.99,-54.1,;28.65,-56.4,;27.32,-55.63,;27.33,-54.09,;26,-53.32,;26,-51.78,;24.66,-54.09,;23.33,-53.32,;24.67,-55.64,;26,-56.4,;26,-57.94,;33.99,-56.41,;35.32,-55.64,)| Show InChI InChI=1S/C24H21F3N4O4S/c25-16-9-18(27)19(10-17(16)26)31-24(35)30-15-5-1-12(2-6-15)20-11-28-22(36-20)21(32)29-14-7-3-13(4-8-14)23(33)34/h1-2,5-6,9-11,13-14H,3-4,7-8H2,(H,29,32)(H,33,34)(H2,30,31,35)/t13-,14-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
VIT University Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using 1,2-diacylglycerol/[14C]-oleoyl CoA as substrate assessed as [14C]-triglyceride formation after 10 mins by scintillat...				Eur J Med Chem 79: 203-15 (2014) Article DOI: 10.1016/j.ejmech.2014.03.077 BindingDB Entry DOI: 10.7270/Q23R0VCD
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071057 (CHEMBL3409713) Show SMILES C1CC1c1cc(Nc2nc(nc3CCCc23)N2CCCCC2)n[nH]1 Show InChI InChI=1S/C18H24N6/c1-2-9-24(10-3-1)18-19-14-6-4-5-13(14)17(21-18)20-16-11-15(22-23-16)12-7-8-12/h11-12H,1-10H2,(H2,19,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005649 (CHEMBL3235425) Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1ncc(s1)-c1ccc(NC(=O)Nc2cc(F)cc(F)c2)cc1 |r,wU:6.9,wD:3.2,(47.51,-36.67,;46.7,-37.98,;47.43,-39.33,;45.16,-37.93,;44.43,-36.57,;42.89,-36.52,;42.09,-37.83,;42.81,-39.19,;44.35,-39.24,;40.55,-37.79,;39.74,-39.1,;40.47,-40.46,;38.2,-39.06,;37.33,-37.79,;35.85,-38.22,;35.81,-39.76,;37.26,-40.28,;34.54,-40.64,;33.21,-39.88,;31.88,-40.65,;31.88,-42.19,;30.54,-42.96,;29.21,-42.19,;29.21,-40.65,;27.87,-42.96,;26.54,-42.19,;25.22,-42.95,;23.89,-42.19,;22.54,-42.97,;23.88,-40.64,;25.22,-39.87,;25.22,-38.32,;26.55,-40.64,;33.21,-42.96,;34.55,-42.19,)| Show InChI InChI=1S/C24H22F2N4O4S/c25-15-9-16(26)11-19(10-15)30-24(34)29-18-5-1-13(2-6-18)20-12-27-22(35-20)21(31)28-17-7-3-14(4-8-17)23(32)33/h1-2,5-6,9-12,14,17H,3-4,7-8H2,(H,28,31)(H,32,33)(H2,29,30,34)/t14-,17-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
VIT University Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using 1,2-diacylglycerol/[14C]-oleoyl CoA as substrate assessed as [14C]-triglyceride formation after 10 mins by scintillat...				Eur J Med Chem 79: 203-15 (2014) Article DOI: 10.1016/j.ejmech.2014.03.077 BindingDB Entry DOI: 10.7270/Q23R0VCD
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071036 (CHEMBL3409718) Show SMILES CCOC(=O)C1CCN(CC1)c1nc2CCCc2c(Nc2cc([nH]n2)C2CC2)n1 Show InChI InChI=1S/C21H28N6O2/c1-2-29-20(28)14-8-10-27(11-9-14)21-22-16-5-3-4-15(16)19(24-21)23-18-12-17(25-26-18)13-6-7-13/h12-14H,2-11H2,1H3,(H2,22,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005653 (CHEMBL3235429) Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1ncc(s1)-c1ccc(NC(=O)Nc2ccc(F)cc2F)cc1 |r,wU:6.9,wD:3.2,(25.13,-47.8,;24.31,-49.11,;25.04,-50.47,;22.78,-49.06,;22.05,-47.71,;20.5,-47.66,;19.7,-48.97,;20.43,-50.33,;21.96,-50.37,;18.16,-48.93,;17.36,-50.24,;18.09,-51.59,;15.82,-50.2,;14.95,-48.93,;13.47,-49.36,;13.43,-50.9,;14.88,-51.42,;12.16,-51.78,;10.82,-51.01,;9.49,-51.78,;9.49,-53.33,;8.16,-54.1,;6.82,-53.33,;6.83,-51.79,;5.49,-54.09,;4.16,-53.32,;4.17,-51.78,;2.84,-51.01,;1.5,-51.78,;.17,-51.01,;1.5,-53.33,;2.84,-54.09,;2.84,-55.63,;10.83,-54.1,;12.16,-53.33,)| Show InChI InChI=1S/C24H22F2N4O4S/c25-15-5-10-19(18(26)11-15)30-24(34)29-17-6-1-13(2-7-17)20-12-27-22(35-20)21(31)28-16-8-3-14(4-9-16)23(32)33/h1-2,5-7,10-12,14,16H,3-4,8-9H2,(H,28,31)(H,32,33)(H2,29,30,34)/t14-,16-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
VIT University Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using 1,2-diacylglycerol/[14C]-oleoyl CoA as substrate assessed as [14C]-triglyceride formation after 10 mins by scintillat...				Eur J Med Chem 79: 203-15 (2014) Article DOI: 10.1016/j.ejmech.2014.03.077 BindingDB Entry DOI: 10.7270/Q23R0VCD
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071031 (CHEMBL3409723) Show SMILES C1CC1c1cc(Nc2nc(nc3CCCc23)N2CC3CCC2C3)n[nH]1 Show InChI InChI=1S/C19H24N6/c1-2-14-15(3-1)20-19(25-10-11-4-7-13(25)8-11)22-18(14)21-17-9-16(23-24-17)12-5-6-12/h9,11-13H,1-8,10H2,(H2,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005655 (CHEMBL3235431) Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1ncc(s1)-c1ccc(NC(=O)Nc2ccccc2)cc1 |r,wU:6.9,wD:3.2,(71.08,-51.02,;70.26,-52.33,;70.99,-53.69,;68.73,-52.28,;68,-50.93,;66.45,-50.88,;65.65,-52.19,;66.38,-53.55,;67.91,-53.59,;64.11,-52.15,;63.31,-53.46,;64.04,-54.81,;61.77,-53.42,;60.9,-52.15,;59.42,-52.58,;59.38,-54.12,;60.83,-54.64,;58.11,-55,;56.77,-54.23,;55.44,-55,;55.44,-56.55,;54.11,-57.32,;52.77,-56.55,;52.78,-55.01,;51.44,-57.31,;50.11,-56.54,;50.12,-55,;48.79,-54.23,;47.45,-55,;47.45,-56.55,;48.79,-57.31,;56.78,-57.32,;58.11,-56.55,)| Show InChI InChI=1S/C24H24N4O4S/c29-21(26-18-12-8-16(9-13-18)23(30)31)22-25-14-20(33-22)15-6-10-19(11-7-15)28-24(32)27-17-4-2-1-3-5-17/h1-7,10-11,14,16,18H,8-9,12-13H2,(H,26,29)(H,30,31)(H2,27,28,32)/t16-,18-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
VIT University Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using 1,2-diacylglycerol/[14C]-oleoyl CoA as substrate assessed as [14C]-triglyceride formation after 10 mins by scintillat...				Eur J Med Chem 79: 203-15 (2014) Article DOI: 10.1016/j.ejmech.2014.03.077 BindingDB Entry DOI: 10.7270/Q23R0VCD
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071032 (CHEMBL3409722) Show SMILES C1CC1c1cc(Nc2nc(nc3CCCc23)N2CCCCCCC2)n[nH]1 Show InChI InChI=1S/C20H28N6/c1-2-4-11-26(12-5-3-1)20-21-16-8-6-7-15(16)19(23-20)22-18-13-17(24-25-18)14-9-10-14/h13-14H,1-12H2,(H2,21,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50354643 (CHEMBL1834206) Show SMILES OC(=O)[C@@H]1CCC[C@H]1C(=O)c1ccc(cc1)-c1ccc(Nc2nc3ccc(F)cc3s2)c(F)c1 |r| Show InChI InChI=1S/C26H20F2N2O3S/c27-17-9-11-22-23(13-17)34-26(30-22)29-21-10-8-16(12-20(21)28)14-4-6-15(7-5-14)24(31)18-2-1-3-19(18)25(32)33/h4-13,18-19H,1-3H2,(H,29,30)(H,32,33)/t18-,19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
VIT University Curated by ChEMBL					Assay Description Inhibition of DGAT1 (unknown origin)				Eur J Med Chem 79: 203-15 (2014) Article DOI: 10.1016/j.ejmech.2014.03.077 BindingDB Entry DOI: 10.7270/Q23R0VCD
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005647 (CHEMBL3235422) Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1ncc(s1)-c1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cc1 |r,wU:6.9,wD:3.2,(28.27,-23.6,;27.46,-24.91,;28.18,-26.27,;25.92,-24.86,;25.19,-23.5,;23.64,-23.45,;22.84,-24.77,;23.57,-26.12,;25.1,-26.17,;21.31,-24.72,;20.5,-26.04,;21.23,-27.39,;18.96,-25.99,;18.09,-24.72,;16.61,-25.16,;16.57,-26.7,;18.02,-27.21,;15.3,-27.57,;13.96,-26.81,;12.64,-27.58,;12.63,-29.12,;11.3,-29.89,;9.97,-29.12,;9.97,-27.58,;8.51,-29.61,;7.25,-28.72,;6.01,-29.63,;6.5,-31.09,;8.04,-31.08,;8.96,-32.32,;8.34,-33.73,;10.49,-32.14,;9.71,-33.65,;4.55,-29.18,;4.22,-27.67,;2.75,-27.21,;1.61,-28.25,;1.95,-29.76,;3.42,-30.21,;13.97,-29.89,;15.31,-29.12,)| Show InChI InChI=1S/C28H23F3N4O5S/c29-28(30,31)22-21(35-25(40-22)16-4-2-1-3-5-16)23(36)33-18-10-6-15(7-11-18)20-14-32-26(41-20)24(37)34-19-12-8-17(9-13-19)27(38)39/h1-7,10-11,14,17,19H,8-9,12-13H2,(H,33,36)(H,34,37)(H,38,39)/t17-,19-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
VIT University Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using 1,2-diacylglycerol/[14C]-oleoyl CoA as substrate assessed as [14C]-triglyceride formation after 10 mins by scintillat...				Eur J Med Chem 79: 203-15 (2014) Article DOI: 10.1016/j.ejmech.2014.03.077 BindingDB Entry DOI: 10.7270/Q23R0VCD
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005648 (CHEMBL3235423) Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1ncc(s1)-c1ccc(NC(=O)c2cc(F)cc(F)c2)cc1 |r,wU:6.9,wD:3.2,(51.34,-23.3,;50.53,-24.61,;51.25,-25.96,;48.99,-24.56,;48.26,-23.2,;46.71,-23.15,;45.91,-24.46,;46.64,-25.82,;48.17,-25.87,;44.37,-24.42,;43.57,-25.73,;44.3,-27.09,;42.03,-25.69,;41.16,-24.42,;39.68,-24.86,;39.64,-26.39,;41.09,-26.91,;38.37,-27.27,;37.03,-26.51,;35.7,-27.28,;35.7,-28.82,;34.37,-29.59,;33.03,-28.82,;33.04,-27.28,;31.7,-29.59,;31.7,-31.12,;30.38,-31.89,;30.38,-33.43,;29.03,-31.12,;29.04,-29.58,;27.7,-28.81,;30.37,-28.81,;37.04,-29.59,;38.37,-28.82,)| Show InChI InChI=1S/C24H21F2N3O4S/c25-16-9-15(10-17(26)11-16)21(30)28-18-5-1-13(2-6-18)20-12-27-23(34-20)22(31)29-19-7-3-14(4-8-19)24(32)33/h1-2,5-6,9-12,14,19H,3-4,7-8H2,(H,28,30)(H,29,31)(H,32,33)/t14-,19-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
VIT University Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using 1,2-diacylglycerol/[14C]-oleoyl CoA as substrate assessed as [14C]-triglyceride formation after 10 mins by scintillat...				Eur J Med Chem 79: 203-15 (2014) Article DOI: 10.1016/j.ejmech.2014.03.077 BindingDB Entry DOI: 10.7270/Q23R0VCD
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071056 (CHEMBL3409714) Show SMILES OCC1CCCN(C1)c1nc2CCCc2c(Nc2cc([nH]n2)C2CC2)n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071026 (CHEMBL3409728) Show SMILES C1CC1c1cc(Nc2nc(nc3CCCc23)-c2ccccc2)n[nH]1 Show InChI InChI=1S/C19H19N5/c1-2-5-13(6-3-1)18-20-15-8-4-7-14(15)19(22-18)21-17-11-16(23-24-17)12-9-10-12/h1-3,5-6,11-12H,4,7-10H2,(H2,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071019 (CHEMBL3409735) Show SMILES CCOC(=O)C1CCCN(C1)c1nc2CCCc2c(Nc2cc([nH]n2)C(C)(C)C)n1 Show InChI InChI=1S/C22H32N6O2/c1-5-30-20(29)14-8-7-11-28(13-14)21-23-16-10-6-9-15(16)19(25-21)24-18-12-17(26-27-18)22(2,3)4/h12,14H,5-11,13H2,1-4H3,(H2,23,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50071014 (CHEMBL3409716) Show SMILES CC1CCN(CC1)c1nc2CCCc2c(Nc2cc([nH]n2)C2CC2)n1 Show InChI InChI=1S/C19H26N6/c1-12-7-9-25(10-8-12)19-20-15-4-2-3-14(15)18(22-19)21-17-11-16(23-24-17)13-5-6-13/h11-13H,2-10H2,1H3,(H2,20,21,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IR (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolved f...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50341782 (4-(4-{4-[(2-Phenyl-5-trifluoromethyloxazole-4-carb...) Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)C(=O)N1CCC(CC1)c1ccc(NC(=O)c2nc(oc2C(F)(F)F)-c2ccccc2)cc1 |r,wU:6.9,wD:3.2,(20.61,-31.2,;19.27,-30.45,;19.25,-28.91,;17.95,-31.23,;16.6,-30.48,;15.28,-31.27,;15.31,-32.8,;16.65,-33.55,;17.96,-32.77,;13.99,-33.59,;14.01,-35.12,;12.65,-32.84,;11.32,-33.63,;9.99,-32.88,;9.97,-31.35,;11.27,-30.55,;12.62,-31.3,;8.62,-30.6,;7.3,-31.4,;5.96,-30.65,;5.92,-29.1,;4.57,-28.36,;3.27,-29.17,;3.32,-30.7,;1.9,-28.44,;.69,-29.39,;-.59,-28.53,;-.17,-27.05,;1.38,-26.98,;2.14,-25.65,;3.68,-25.64,;1.37,-24.32,;2.76,-24.25,;-1.94,-29.27,;-3.26,-28.47,;-4.61,-29.21,;-4.65,-30.75,;-3.32,-31.55,;-1.97,-30.81,;7.25,-28.31,;8.6,-29.06,)| Show InChI InChI=1S/C30H30F3N3O5/c31-30(32,33)25-24(35-27(41-25)20-4-2-1-3-5-20)26(37)34-23-12-10-18(11-13-23)19-14-16-36(17-15-19)28(38)21-6-8-22(9-7-21)29(39)40/h1-5,10-13,19,21-22H,6-9,14-17H2,(H,34,37)(H,39,40)/t21-,22-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	114	n/a	n/a	n/a	n/a	n/a	n/a
VIT University Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using 1,2-diacylglycerol/[14C]-oleoyl CoA as substrate assessed as [14C]-triglyceride formation after 10 mins by scintillat...				Eur J Med Chem 79: 203-15 (2014) Article DOI: 10.1016/j.ejmech.2014.03.077 BindingDB Entry DOI: 10.7270/Q23R0VCD
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071035 (CHEMBL3409719) Show SMILES N#CC1CCN(CC1)c1nc2CCCc2c(Nc2cc([nH]n2)C2CC2)n1 Show InChI InChI=1S/C19H23N7/c20-11-12-6-8-26(9-7-12)19-21-15-3-1-2-14(15)18(23-19)22-17-10-16(24-25-17)13-4-5-13/h10,12-13H,1-9H2,(H2,21,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071029 (CHEMBL3409725) Show SMILES Cc1ccc(CNc2nc3CCCc3c(Nc3cc([nH]n3)C3CC3)n2)cc1 Show InChI InChI=1S/C21H24N6/c1-13-5-7-14(8-6-13)12-22-21-23-17-4-2-3-16(17)20(25-21)24-19-11-18(26-27-19)15-9-10-15/h5-8,11,15H,2-4,9-10,12H2,1H3,(H3,22,23,24,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	149	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human))	BDBM50005650 (CHEMBL3235426) Show SMILES COc1ccccc1NC(=O)Nc1ccc(cc1)-c1cnc(s1)C(=O)N[C@H]1CC[C@@H](CC1)C(O)=O |r,wU:26.28,wD:29.35,(1.32,-43.95,;2.65,-43.18,;2.64,-41.64,;1.31,-40.88,;1.31,-39.33,;2.64,-38.56,;3.97,-39.33,;3.96,-40.87,;5.3,-41.64,;6.63,-40.87,;6.63,-39.33,;7.96,-41.64,;9.3,-40.88,;9.3,-39.33,;10.63,-38.56,;11.96,-39.32,;11.97,-40.87,;10.63,-41.65,;13.23,-38.45,;13.28,-36.91,;14.75,-36.47,;15.62,-37.75,;14.68,-38.97,;17.16,-37.79,;17.9,-39.14,;17.97,-36.48,;19.51,-36.52,;20.31,-35.21,;21.85,-35.26,;22.58,-36.61,;21.77,-37.92,;20.23,-37.88,;24.12,-36.66,;24.93,-35.35,;24.85,-38.02,)| Show InChI InChI=1S/C25H26N4O5S/c1-34-20-5-3-2-4-19(20)29-25(33)28-18-10-6-15(7-11-18)21-14-26-23(35-21)22(30)27-17-12-8-16(9-13-17)24(31)32/h2-7,10-11,14,16-17H,8-9,12-13H2,1H3,(H,27,30)(H,31,32)(H2,28,29,33)/t16-,17-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
VIT University Curated by ChEMBL					Assay Description Inhibition of human DGAT1 using 1,2-diacylglycerol/[14C]-oleoyl CoA as substrate assessed as [14C]-triglyceride formation after 10 mins by scintillat...				Eur J Med Chem 79: 203-15 (2014) Article DOI: 10.1016/j.ejmech.2014.03.077 BindingDB Entry DOI: 10.7270/Q23R0VCD
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071038 (CHEMBL3409715) Show SMILES CCN(CC)C(=O)C1CCCN(C1)c1nc2CCCc2c(Nc2cc([nH]n2)C2CC2)n1 Show InChI InChI=1S/C23H33N7O/c1-3-29(4-2)22(31)16-7-6-12-30(14-16)23-24-18-9-5-8-17(18)21(26-23)25-20-13-19(27-28-20)15-10-11-15/h13,15-16H,3-12,14H2,1-2H3,(H2,24,25,26,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	184	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402299 (CHEMBL2206064) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(Oc2ccccc2)cccc1C(F)(F)F Show InChI InChI=1S/C21H16F3N5O/c1-26-18-13-10-11-15(27-19(13)29-20(25)28-18)17-14(21(22,23)24)8-5-9-16(17)30-12-6-3-2-4-7-12/h2-11H,1H3,(H3,25,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071037 (CHEMBL3409717) Show SMILES CC1(C)CCN(CC1)c1nc2CCCc2c(Nc2cc([nH]n2)C2CC2)n1 Show InChI InChI=1S/C20H28N6/c1-20(2)8-10-26(11-9-20)19-21-15-5-3-4-14(15)18(23-19)22-17-12-16(24-25-17)13-6-7-13/h12-13H,3-11H2,1-2H3,(H2,21,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	203	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402291 (CHEMBL2206071) Show SMILES CNc1nc(N)nc2nc(c(cc12)C(O)=O)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C16H12F3N5O2/c1-21-12-9-6-8(14(25)26)11(22-13(9)24-15(20)23-12)7-4-2-3-5-10(7)16(17,18)19/h2-6H,1H3,(H,25,26)(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071022 (CHEMBL3409732) Show SMILES CC(C)(C)c1cc(Nc2nc(nc3CCCc23)N2CCCCC2)n[nH]1 Show InChI InChI=1S/C19H28N6/c1-19(2,3)15-12-16(24-23-15)21-17-13-8-7-9-14(13)20-18(22-17)25-10-5-4-6-11-25/h12H,4-11H2,1-3H3,(H2,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402302 (CHEMBL2205521) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(F)cccc1C(F)(F)F Show InChI InChI=1S/C15H11F4N5/c1-21-12-7-5-6-10(22-13(7)24-14(20)23-12)11-8(15(17,18)19)3-2-4-9(11)16/h2-6H,1H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071030 (CHEMBL3409724) Show SMILES C(Nc1nc2CCCc2c(Nc2cc([nH]n2)C2CC2)n1)c1ccccc1 Show InChI InChI=1S/C20H22N6/c1-2-5-13(6-3-1)12-21-20-22-16-8-4-7-15(16)19(24-20)23-18-11-17(25-26-18)14-9-10-14/h1-3,5-6,11,14H,4,7-10,12H2,(H3,21,22,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	267	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402292 (CHEMBL2206070) Show SMILES CCCc1cc2c(NC)nc(N)nc2nc1-c1ccccc1C(F)(F)F Show InChI InChI=1S/C18H18F3N5/c1-3-6-10-9-12-15(23-2)25-17(22)26-16(12)24-14(10)11-7-4-5-8-13(11)18(19,20)21/h4-5,7-9H,3,6H2,1-2H3,(H3,22,23,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071021 (CHEMBL3409733) Show SMILES CC1CCN(CC1)c1nc2CCCc2c(Nc2cc([nH]n2)C(C)(C)C)n1 Show InChI InChI=1S/C20H30N6/c1-13-8-10-26(11-9-13)19-21-15-7-5-6-14(15)18(23-19)22-17-12-16(24-25-17)20(2,3)4/h12-13H,5-11H2,1-4H3,(H2,21,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402300 (CHEMBL2206063) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(SC)cccc1C(F)(F)F Show InChI InChI=1S/C16H14F3N5S/c1-21-13-8-6-7-10(22-14(8)24-15(20)23-13)12-9(16(17,18)19)4-3-5-11(12)25-2/h3-7H,1-2H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402296 (CHEMBL2206067) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(cccc1C(F)(F)F)N1CCCC1 Show InChI InChI=1S/C19H19F3N6/c1-24-16-11-7-8-13(25-17(11)27-18(23)26-16)15-12(19(20,21)22)5-4-6-14(15)28-9-2-3-10-28/h4-8H,2-3,9-10H2,1H3,(H3,23,24,25,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	430	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071025 (CHEMBL3409729) Show SMILES Cc1cc(Nc2nc(nc3CCCc23)N2CCCCC2)n[nH]1 Show InChI InChI=1S/C16H22N6/c1-11-10-14(21-20-11)18-15-12-6-5-7-13(12)17-16(19-15)22-8-3-2-4-9-22/h10H,2-9H2,1H3,(H2,17,18,19,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	442	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402316 (CHEMBL2206073) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C15H12F3N5/c1-20-12-9-6-7-11(21-13(9)23-14(19)22-12)8-4-2-3-5-10(8)15(16,17)18/h2-7H,1H3,(H3,19,20,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402293 (CHEMBL2203315) Show SMILES CNc1nc(N)nc2nc(c(C)cc12)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C16H14F3N5/c1-8-7-10-13(21-2)23-15(20)24-14(10)22-12(8)9-5-3-4-6-11(9)16(17,18)19/h3-7H,1-2H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402303 (CHEMBL2205520) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(Cl)cccc1Cl Show InChI InChI=1S/C14H11Cl2N5/c1-18-12-7-5-6-10(19-13(7)21-14(17)20-12)11-8(15)3-2-4-9(11)16/h2-6H,1H3,(H3,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402308 (CHEMBL2205515) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1ccccc1Br Show InChI InChI=1S/C14H12BrN5/c1-17-12-9-6-7-11(8-4-2-3-5-10(8)15)18-13(9)20-14(16)19-12/h2-7H,1H3,(H3,16,17,18,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402301 (CHEMBL2205522) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(OC)cccc1C(F)(F)F Show InChI InChI=1S/C16H14F3N5O/c1-21-13-8-6-7-10(22-14(8)24-15(20)23-13)12-9(16(17,18)19)4-3-5-11(12)25-2/h3-7H,1-2H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071020 (CHEMBL3409734) Show SMILES CC(C)(C)c1cc(Nc2nc(nc3CCCc23)N2CCCCCC2)n[nH]1 Show InChI InChI=1S/C20H30N6/c1-20(2,3)16-13-17(25-24-16)22-18-14-9-8-10-15(14)21-19(23-18)26-11-6-4-5-7-12-26/h13H,4-12H2,1-3H3,(H2,21,22,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	568	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402305 (CHEMBL2205518) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C14H11Cl2N5/c1-18-12-9-4-5-11(19-13(9)21-14(17)20-12)8-3-2-7(15)6-10(8)16/h2-6H,1H3,(H3,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402294 (CHEMBL2206069) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(F)cccc1N1CCCC1 Show InChI InChI=1S/C18H19FN6/c1-21-16-11-7-8-13(22-17(11)24-18(20)23-16)15-12(19)5-4-6-14(15)25-9-2-3-10-25/h4-8H,2-3,9-10H2,1H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071017 (CHEMBL3409737) Show SMILES CC1CCN(CC1)c1nc2c(CCC2(F)F)c(Nc2cc([nH]n2)C2CC2)n1 Show InChI InChI=1S/C19H24F2N6/c1-11-5-8-27(9-6-11)18-23-16-13(4-7-19(16,20)21)17(24-18)22-15-10-14(25-26-15)12-2-3-12/h10-12H,2-9H2,1H3,(H2,22,23,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	786	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402295 (CHEMBL2206068) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1c(Cl)cccc1N1CCCC1 Show InChI InChI=1S/C18H19ClN6/c1-21-16-11-7-8-13(22-17(11)24-18(20)23-16)15-12(19)5-4-6-14(15)25-9-2-3-10-25/h4-8H,2-3,9-10H2,1H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	820	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402304 (CHEMBL2205519) Show SMILES CNc1nc(N)nc2nc(ccc12)-c1cc(Cl)ccc1Cl Show InChI InChI=1S/C14H11Cl2N5/c1-18-12-8-3-5-11(19-13(8)21-14(17)20-12)9-6-7(15)2-4-10(9)16/h2-6H,1H3,(H3,17,18,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071023 (CHEMBL3409731) Show SMILES CCOC(=O)C1CCCN(C1)c1nc2CCCc2c(Nc2cc(C)[nH]n2)n1 Show InChI InChI=1S/C19H26N6O2/c1-3-27-18(26)13-6-5-9-25(11-13)19-20-15-8-4-7-14(15)17(22-19)21-16-10-12(2)23-24-16/h10,13H,3-9,11H2,1-2H3,(H2,20,21,22,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair
Tyrosine-protein phosphatase non-receptor type 1 (Homo sapiens (Human))	BDBM50402290 (CHEMBL2206072) Show SMILES CNc1nc(N)nc2nc(-c3ccccc3C(F)(F)F)c(cc12)S(C)(=O)=O Show InChI InChI=1S/C16H14F3N5O2S/c1-21-13-9-7-11(27(2,25)26)12(22-14(9)24-15(20)23-13)8-5-3-4-6-10(8)16(17,18)19/h3-7H,1-2H3,(H3,20,21,22,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Roche Research Center Curated by ChEMBL					Assay Description Inhibition of human PTP1B (1 to 321 amino acid residues) expressed in Escherichia coli using TRDI(pY)E as substrate incubated for 15 mins prior to su...				Bioorg Med Chem Lett 22: 7518-22 (2012) Article DOI: 10.1016/j.bmcl.2012.10.035 BindingDB Entry DOI: 10.7270/Q2VQ33V6
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50071059 (CHEMBL3409712) Show SMILES C1CC1c1cc(Nc2nc(nc3CCCc23)N2CCNCC2)n[nH]1 Show InChI InChI=1S/C17H23N7/c1-2-12-13(3-1)19-17(24-8-6-18-7-9-24)21-16(12)20-15-10-14(22-23-15)11-4-5-11/h10-11,18H,1-9H2,(H2,19,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Piramal Enterprises Limited Curated by ChEMBL					Assay Description Inhibition of IGF1R (unknown origin) using poly-G1 as substrate incubated for 10 mins prior to substrate addition measured after 1 hr by time-resolve...				Eur J Med Chem 92: 246-56 (2015) Article DOI: 10.1016/j.ejmech.2014.12.053 BindingDB Entry DOI: 10.7270/Q2639RFV
					More data for this Ligand-Target Pair

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