Compile Data Set for Download or QSAR

Found 584 hits with Last Name = 'bready' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17689 (2-aminobenzimidazole, 14 | N-{4-chloro-3-[(4-methy...) Show SMILES COc1cc2nccc(Oc3ccc4nc(Nc5ccc(Cl)c(CN6CCN(C)CC6)c5)[nH]c4c3)c2cc1OC Show InChI InChI=1S/C30H31ClN6O3/c1-36-10-12-37(13-11-36)18-19-14-20(4-6-23(19)31)33-30-34-24-7-5-21(15-26(24)35-30)40-27-8-9-32-25-17-29(39-3)28(38-2)16-22(25)27/h4-9,14-17H,10-13,18H2,1-3H3,(H2,33,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	0.200	-54.8	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17703 (2-aminobenzoxazole, 28 | N-(4-chloro-3-{[(2S)-1-me...) Show SMILES COc1cc2ncnc(Oc3ccc4oc(Nc5ccc(Cl)c(OC[C@@H]6CCCN6C)c5)nc4c3)c2cc1OC |r| Show InChI InChI=1S/C29H28ClN5O5/c1-35-10-4-5-18(35)15-38-25-11-17(6-8-21(25)30)33-29-34-23-12-19(7-9-24(23)40-29)39-28-20-13-26(36-2)27(37-3)14-22(20)31-16-32-28/h6-9,11-14,16,18H,4-5,10,15H2,1-3H3,(H,33,34)/t18-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17705 (2-aminobenzoxazole, 30 | N-{4-chloro-3-[(4-methylp...) Show SMILES COc1cc2nccc(Oc3ccc4oc(Nc5ccc(Cl)c(CN6CCN(C)CC6)c5)nc4c3)c2cc1OC Show InChI InChI=1S/C30H30ClN5O4/c1-35-10-12-36(13-11-35)18-19-14-20(4-6-23(19)31)33-30-34-25-15-21(5-7-27(25)40-30)39-26-8-9-32-24-17-29(38-3)28(37-2)16-22(24)26/h4-9,14-17H,10-13,18H2,1-3H3,(H,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17704 (2-aminobenzoxazole, 29 | N-(4-chloro-3-{[(2S)-1-me...) Show SMILES COc1cc2nccc(Oc3ccc4oc(Nc5ccc(Cl)c(OC[C@@H]6CCCN6C)c5)nc4c3)c2cc1OC |r| Show InChI InChI=1S/C30H29ClN4O5/c1-35-12-4-5-19(35)17-38-27-13-18(6-8-22(27)31)33-30-34-24-14-20(7-9-26(24)40-30)39-25-10-11-32-23-16-29(37-3)28(36-2)15-21(23)25/h6-11,13-16,19H,4-5,12,17H2,1-3H3,(H,33,34)/t19-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17687 (2-aminobenzimidazole, 12 | N-(3-{[(2R)-1-methylpyr...) Show SMILES CN1CCC[C@@H]1COc1cc(Nc2nc3ccc(Oc4ccnc5ccccc45)cc3[nH]2)ccc1C(F)(F)F |r| Show InChI InChI=1S/C29H26F3N5O2/c1-37-14-4-5-19(37)17-38-27-15-18(8-10-22(27)29(30,31)32)34-28-35-24-11-9-20(16-25(24)36-28)39-26-12-13-33-23-7-3-2-6-21(23)26/h2-3,6-13,15-16,19H,4-5,14,17H2,1H3,(H2,34,35,36)/t19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	1	-50.9	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17709 (2-aminobenzoxazole, 34 | N-(4-chloro-3-{[(2S)-1-me...) Show SMILES CN1CCC[C@H]1COc1cc(Nc2nc3cc(Oc4ccnc5[nH]ccc45)ccc3o2)ccc1Cl |r| Show InChI InChI=1S/C26H24ClN5O3/c1-32-12-2-3-17(32)15-33-24-13-16(4-6-20(24)27)30-26-31-21-14-18(5-7-23(21)35-26)34-22-9-11-29-25-19(22)8-10-28-25/h4-11,13-14,17H,2-3,12,15H2,1H3,(H,28,29)(H,30,31)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17684 (2-aminobenzimidazole, 9 | N-methyl-4-({2-[(3-{[(2R...) Show SMILES CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(c(OC[C@H]5CCCN5C)c4)C(F)(F)F)[nH]c3c2)ccn1 |r| Show InChI InChI=1S/C27H27F3N6O3/c1-31-25(37)23-14-19(9-10-32-23)39-18-6-8-21-22(13-18)35-26(34-21)33-16-5-7-20(27(28,29)30)24(12-16)38-15-17-4-3-11-36(17)2/h5-10,12-14,17H,3-4,11,15H2,1-2H3,(H,31,37)(H2,33,34,35)/t17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2	-49.2	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222500 (CHEMBL250482 | N-(4-cyclohexylphenyl)-2-(pyridin-4...) Show SMILES O=C(Nc1ccc(cc1)C1CCCCC1)c1cccnc1NCc1ccncc1 Show InChI InChI=1S/C24H26N4O/c29-24(28-21-10-8-20(9-11-21)19-5-2-1-3-6-19)22-7-4-14-26-23(22)27-17-18-12-15-25-16-13-18/h4,7-16,19H,1-3,5-6,17H2,(H,26,27)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17713 (2-aminobenzoxazole, 38 | 7-chloro-N-{4-chloro-3-[(...) Show SMILES CN1CCN(Cc2cc(Nc3nc4cc(Oc5ccnc6ccccc56)cc(Cl)c4o3)ccc2Cl)CC1 Show InChI InChI=1S/C28H25Cl2N5O2/c1-34-10-12-35(13-11-34)17-18-14-19(6-7-22(18)29)32-28-33-25-16-20(15-23(30)27(25)37-28)36-26-8-9-31-24-5-3-2-4-21(24)26/h2-9,14-16H,10-13,17H2,1H3,(H,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17710 (2-aminobenzoxazole, 35 | N-{4-chloro-3-[(4-methylp...) Show SMILES CN1CCN(Cc2cc(Nc3nc4cc(Oc5ccnc6[nH]ccc56)ccc4o3)ccc2Cl)CC1 Show InChI InChI=1S/C26H25ClN6O2/c1-32-10-12-33(13-11-32)16-17-14-18(2-4-21(17)27)30-26-31-22-15-19(3-5-24(22)35-26)34-23-7-9-29-25-20(23)6-8-28-25/h2-9,14-15H,10-13,16H2,1H3,(H,28,29)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17688 (2-aminobenzimidazole, 13 | N-{4-chloro-3-[(4-methy...) Show SMILES CN1CCN(Cc2cc(Nc3nc4ccc(Oc5ccnc6ccccc56)cc4[nH]3)ccc2Cl)CC1 Show InChI InChI=1S/C28H27ClN6O/c1-34-12-14-35(15-13-34)18-19-16-20(6-8-23(19)29)31-28-32-25-9-7-21(17-26(25)33-28)36-27-10-11-30-24-5-3-2-4-22(24)27/h2-11,16-17H,12-15,18H2,1H3,(H2,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	2	-49.2	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222499 (CHEMBL401153 | N-(3-chlorophenyl)-2-(pyridin-4-ylm...) Show SMILES Clc1cccc(NC(=O)c2cccnc2NCc2ccncc2)c1 Show InChI InChI=1S/C18H15ClN4O/c19-14-3-1-4-15(11-14)23-18(24)16-5-2-8-21-17(16)22-12-13-6-9-20-10-7-13/h1-11H,12H2,(H,21,22)(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17697 (2-aminobenzoxazole, 22 | 4-({2-[(4-chloro-3-{[(2S)...) Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(OC[C@@H]5CCCN5C)c4)nc3c2)ccn1 |r| Show InChI InChI=1S/C26H26ClN5O4/c1-28-25(33)22-14-19(9-10-29-22)35-18-6-8-23-21(13-18)31-26(36-23)30-16-5-7-20(27)24(12-16)34-15-17-4-3-11-32(17)2/h5-10,12-14,17H,3-4,11,15H2,1-2H3,(H,28,33)(H,30,31)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	2.80	-48.3	4.60	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17701 (2-aminobenzoxazole, 26 | 4-[(2-{[4-chloro-3-(piper...) Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(OCC5CCNCC5)c4)nc3c2)ccn1 Show InChI InChI=1S/C26H26ClN5O4/c1-28-25(33)22-14-19(8-11-30-22)35-18-3-5-23-21(13-18)32-26(36-23)31-17-2-4-20(27)24(12-17)34-15-16-6-9-29-10-7-16/h2-5,8,11-14,16,29H,6-7,9-10,15H2,1H3,(H,28,33)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17683 (2-aminobenzimidazole, 8 | 4-{[2-({3-[2-(dimethylam...) Show SMILES CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(c(OCCN(C)C)c4)C(F)(F)F)[nH]c3c2)ccn1 Show InChI InChI=1S/C25H25F3N6O3/c1-29-23(35)21-14-17(8-9-30-21)37-16-5-7-19-20(13-16)33-24(32-19)31-15-4-6-18(25(26,27)28)22(12-15)36-11-10-34(2)3/h4-9,12-14H,10-11H2,1-3H3,(H,29,35)(H2,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	3	-48.2	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17691 (2-aminobenzimidazole, 16 | N-{4-chloro-3-[(4-methy...) Show SMILES CN1CCN(Cc2cc(Nc3nc4ccc(Oc5ccnc6[nH]ccc56)cc4[nH]3)ccc2Cl)CC1 Show InChI InChI=1S/C26H26ClN7O/c1-33-10-12-34(13-11-33)16-17-14-18(2-4-21(17)27)30-26-31-22-5-3-19(15-23(22)32-26)35-24-7-9-29-25-20(24)6-8-28-25/h2-9,14-15H,10-13,16H2,1H3,(H,28,29)(H2,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	3	-48.2	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17711 (2-aminobenzoxazole, 36 | 4-({2-[(4-chloro-3-{[(2S)...) Show SMILES CNC(=O)c1cc(Oc2cc(F)c3oc(Nc4ccc(Cl)c(OC[C@@H]5CCCN5C)c4)nc3c2)ccn1 |r| Show InChI InChI=1S/C26H25ClFN5O4/c1-29-25(34)22-12-17(7-8-30-22)36-18-11-20(28)24-21(13-18)32-26(37-24)31-15-5-6-19(27)23(10-15)35-14-16-4-3-9-33(16)2/h5-8,10-13,16H,3-4,9,14H2,1-2H3,(H,29,34)(H,31,32)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17702 (2-aminobenzoxazole, 27 | 4-({2-[(4-chloro-3-{[(2S)...) Show SMILES CN1CCC[C@H]1COc1cc(Nc2nc3cc(Oc4ccnc(c4)C(N)=O)ccc3o2)ccc1Cl |r| Show InChI InChI=1S/C25H24ClN5O4/c1-31-10-2-3-16(31)14-33-23-11-15(4-6-19(23)26)29-25-30-20-12-17(5-7-22(20)35-25)34-18-8-9-28-21(13-18)24(27)32/h4-9,11-13,16H,2-3,10,14H2,1H3,(H2,27,32)(H,29,30)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17706 (2-aminobenzoxazole, 31 | N-{4-chloro-3-[(4-methylp...) Show SMILES CN1CCN(Cc2cc(Nc3nc4cc(Oc5ccnc6ccccc56)ccc4o3)ccc2Cl)CC1 Show InChI InChI=1S/C28H26ClN5O2/c1-33-12-14-34(15-13-33)18-19-16-20(6-8-23(19)29)31-28-32-25-17-21(7-9-27(25)36-28)35-26-10-11-30-24-5-3-2-4-22(24)26/h2-11,16-17H,12-15,18H2,1H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	3.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17682 (2-aminobenzimidazole, 7 | 4-{[2-({4-chloro-3-[(4-m...) Show SMILES CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)[nH]c3c2)ccn1 Show InChI InChI=1S/C26H28ClN7O2/c1-28-25(35)24-15-20(7-8-29-24)36-19-4-6-22-23(14-19)32-26(31-22)30-18-3-5-21(27)17(13-18)16-34-11-9-33(2)10-12-34/h3-8,13-15H,9-12,16H2,1-2H3,(H,28,35)(H2,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	3.90	-47.5	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17700 (2-aminobenzoxazole, 25 | 4-[(2-{[4-chloro-3-(morph...) Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(CN5CCOCC5)c4)nc3c2)ccn1 Show InChI InChI=1S/C25H24ClN5O4/c1-27-24(32)22-14-19(6-7-28-22)34-18-3-5-23-21(13-18)30-25(35-23)29-17-2-4-20(26)16(12-17)15-31-8-10-33-11-9-31/h2-7,12-14H,8-11,15H2,1H3,(H,27,32)(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222501 (CHEMBL250684 | N-(4-chloro-3-(trifluoromethyl)phen...) Show SMILES FC(F)(F)c1cc(NC(=O)c2cccnc2NCc2ccncc2)ccc1Cl Show InChI InChI=1S/C19H14ClF3N4O/c20-16-4-3-13(10-15(16)19(21,22)23)27-18(28)14-2-1-7-25-17(14)26-11-12-5-8-24-9-6-12/h1-10H,11H2,(H,25,26)(H,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17695 (2-aminobenzoxazole, 20 | 4-{[2-({4-chloro-3-[(4-me...) Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)nc3c2)ccn1 Show InChI InChI=1S/C26H27ClN6O3/c1-28-25(34)23-15-20(7-8-29-23)35-19-4-6-24-22(14-19)31-26(36-24)30-18-3-5-21(27)17(13-18)16-33-11-9-32(2)10-12-33/h3-8,13-15H,9-12,16H2,1-2H3,(H,28,34)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	4	-47.5	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17698 (2-aminobenzoxazole, 23 | 4-{[2-({4-chloro-3-[2-(di...) Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(OCCN(C)C)c4)nc3c2)ccn1 Show InChI InChI=1S/C24H24ClN5O4/c1-26-23(31)20-14-17(8-9-27-20)33-16-5-7-21-19(13-16)29-24(34-21)28-15-4-6-18(25)22(12-15)32-11-10-30(2)3/h4-9,12-14H,10-11H2,1-3H3,(H,26,31)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17699 (2-aminobenzoxazole, 24 | 4-{[2-({4-chloro-3-[2-(di...) Show SMILES CCN(CC)CCOc1cc(Nc2nc3cc(Oc4ccnc(c4)C(=O)NC)ccc3o2)ccc1Cl Show InChI InChI=1S/C26H28ClN5O4/c1-4-32(5-2)12-13-34-24-14-17(6-8-20(24)27)30-26-31-21-15-18(7-9-23(21)36-26)35-19-10-11-29-22(16-19)25(33)28-3/h6-11,14-16H,4-5,12-13H2,1-3H3,(H,28,33)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222498 (CHEMBL400512 | N-(3,5-bis(trifluoromethyl)phenyl)-...) Show SMILES FC(F)(F)c1cc(NC(=O)c2cccnc2NCc2ccncc2)cc(c1)C(F)(F)F Show InChI InChI=1S/C20H14F6N4O/c21-19(22,23)13-8-14(20(24,25)26)10-15(9-13)30-18(31)16-2-1-5-28-17(16)29-11-12-3-6-27-7-4-12/h1-10H,11H2,(H,28,29)(H,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222509 (CHEMBL250228 | N-(4-chlorophenyl)-2-(pyridin-4-ylm...) Show SMILES Clc1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1 Show InChI InChI=1S/C18H15ClN4O/c19-14-3-5-15(6-4-14)23-18(24)16-2-1-9-21-17(16)22-12-13-7-10-20-11-8-13/h1-11H,12H2,(H,21,22)(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of unphosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17680 (2-aminobenzimidazole, 5 | N-(4-chlorophenyl)-5-[(6...) Show SMILES COc1cc2ncnc(Oc3ccc4nc(Nc5ccc(Cl)cc5)[nH]c4c3)c2cc1OC Show InChI InChI=1S/C23H18ClN5O3/c1-30-20-10-16-18(11-21(20)31-2)25-12-26-22(16)32-15-7-8-17-19(9-15)29-23(28-17)27-14-5-3-13(24)4-6-14/h3-12H,1-2H3,(H2,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	8	-45.7	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17685 (2-aminobenzimidazole, 10 | N-methyl-4-({2-[(3-{[(2...) Show SMILES CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(c(OC[C@H]5CCCN5C)c4)C(F)(F)C(F)(F)F)[nH]c3c2)ccn1 |r| Show InChI InChI=1S/C28H27F5N6O3/c1-34-25(40)23-14-19(9-10-35-23)42-18-6-8-21-22(13-18)38-26(37-21)36-16-5-7-20(27(29,30)28(31,32)33)24(12-16)41-15-17-4-3-11-39(17)2/h5-10,12-14,17H,3-4,11,15H2,1-2H3,(H,34,40)(H2,36,37,38)/t17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	9	-45.5	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17678 (2-aminobenzimidazole, 3 | 4-[(2-{[4-chloro-3-(trif...) Show SMILES CNC(=O)c1cc(Oc2ccc3nc(Nc4ccc(Cl)c(c4)C(F)(F)F)[nH]c3c2)ccn1 Show InChI InChI=1S/C21H15ClF3N5O2/c1-26-19(31)18-10-13(6-7-27-18)32-12-3-5-16-17(9-12)30-20(29-16)28-11-2-4-15(22)14(8-11)21(23,24)25/h2-10H,1H3,(H,26,31)(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	9	-45.5	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222512 (2-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethyl)...) Show SMILES FC(F)(F)c1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1 Show InChI InChI=1S/C19H15F3N4O/c20-19(21,22)14-3-5-15(6-4-14)26-18(27)16-2-1-9-24-17(16)25-12-13-7-10-23-11-8-13/h1-11H,12H2,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17694 (2-aminobenzimidazole, 19 | 4-{[2-({4-chloro-3-[(4-...) Show SMILES CNC(=O)c1cc(Oc2ccc3n(C)c(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)nc3c2)ccn1 Show InChI InChI=1S/C27H30ClN7O2/c1-29-26(36)24-16-21(8-9-30-24)37-20-5-7-25-23(15-20)32-27(34(25)3)31-19-4-6-22(28)18(14-19)17-35-12-10-33(2)11-13-35/h4-9,14-16H,10-13,17H2,1-3H3,(H,29,36)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	10	-45.2	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM15019 (CHEMBL385178 | N-(4-phenoxyphenyl)-2-[(pyridin-4-y...) Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)c1cccnc1NCc1ccncc1 Show InChI InChI=1S/C24H20N4O2/c29-24(22-7-4-14-26-23(22)27-17-18-12-15-25-16-13-18)28-19-8-10-21(11-9-19)30-20-5-2-1-3-6-20/h1-16H,17H2,(H,26,27)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair				3D Structure (crystal)
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17712 (2-aminobenzoxazole, 37 | 4-{[7-chloro-2-({4-chloro...) Show SMILES CNC(=O)c1cc(Oc2cc(Cl)c3oc(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)nc3c2)ccn1 Show InChI InChI=1S/C26H26Cl2N6O3/c1-29-25(35)23-13-18(5-6-30-23)36-19-12-21(28)24-22(14-19)32-26(37-24)31-17-3-4-20(27)16(11-17)15-34-9-7-33(2)8-10-34/h3-6,11-14H,7-10,15H2,1-2H3,(H,29,35)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17696 (2-aminobenzoxazole, 21 | 4-({2-[(4-chlorophenyl)am...) Show SMILES CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)cc4)nc3c2)ccn1 Show InChI InChI=1S/C20H15ClN4O3/c1-22-19(26)17-11-15(8-9-23-17)27-14-6-7-18-16(10-14)25-20(28-18)24-13-4-2-12(21)3-5-13/h2-11H,1H3,(H,22,26)(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	12	-44.8	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50132151 (CHEMBL101683 | N-(4-Chloro-phenyl)-2-[(pyridin-4-y...) Show SMILES Clc1ccc(NC(=O)c2ccccc2NCc2ccncc2)cc1 Show InChI InChI=1S/C19H16ClN3O/c20-15-5-7-16(8-6-15)23-19(24)17-3-1-2-4-18(17)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	15	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17690 (2-aminobenzimidazole, 15 | N-{4-chloro-3-[(4-methy...) Show SMILES CN1CCN(Cc2cc(Nc3nc4ccc(Oc5ncnc6[nH]ccc56)cc4[nH]3)ccc2Cl)CC1 Show InChI InChI=1S/C25H25ClN8O/c1-33-8-10-34(11-9-33)14-16-12-17(2-4-20(16)26)30-25-31-21-5-3-18(13-22(21)32-25)35-24-19-6-7-27-23(19)28-15-29-24/h2-7,12-13,15H,8-11,14H2,1H3,(H,27,28,29)(H2,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	17	-43.9	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222513 (CHEMBL248781 | N-(3,4-dichlorophenyl)-2-(pyridin-4...) Show SMILES Clc1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1Cl Show InChI InChI=1S/C18H14Cl2N4O/c19-15-4-3-13(10-16(15)20)24-18(25)14-2-1-7-22-17(14)23-11-12-5-8-21-9-6-12/h1-10H,11H2,(H,22,23)(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222516 (CHEMBL400140 | N-(4-butylphenyl)-2-(pyridin-4-ylme...) Show SMILES CCCCc1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1 Show InChI InChI=1S/C22H24N4O/c1-2-3-5-17-7-9-19(10-8-17)26-22(27)20-6-4-13-24-21(20)25-16-18-11-14-23-15-12-18/h4,6-15H,2-3,5,16H2,1H3,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17708 (2-aminobenzoxazole, 33 | N-{4-chloro-3-[(4-methylp...) Show SMILES CNc1cc(Oc2ccc3oc(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)nc3c2)ncn1 Show InChI InChI=1S/C24H26ClN7O2/c1-26-22-13-23(28-15-27-22)33-18-4-6-21-20(12-18)30-24(34-21)29-17-3-5-19(25)16(11-17)14-32-9-7-31(2)8-10-32/h3-6,11-13,15H,7-10,14H2,1-2H3,(H,29,30)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222517 (2-(pyridin-4-ylmethylamino)-N-(4-(trifluoromethoxy...) Show SMILES FC(F)(F)Oc1ccc(NC(=O)c2cccnc2NCc2ccncc2)cc1 Show InChI InChI=1S/C19H15F3N4O2/c20-19(21,22)28-15-5-3-14(4-6-15)26-18(27)16-2-1-9-24-17(16)25-12-13-7-10-23-11-8-13/h1-11H,12H2,(H,24,25)(H,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222503 (CHEMBL248976 | N-biphenyl-4-yl-2-[(pyridin-4-ylmet...) Show SMILES O=C(Nc1ccc(cc1)-c1ccccc1)c1cccnc1NCc1ccncc1 Show InChI InChI=1S/C24H20N4O/c29-24(28-21-10-8-20(9-11-21)19-5-2-1-3-6-19)22-7-4-14-26-23(22)27-17-18-12-15-25-16-13-18/h1-16H,17H2,(H,26,27)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17707 (2-aminobenzoxazole, 32 | N-{4-chloro-3-[(4-methylp...) Show SMILES CNc1nccc(Oc2ccc3oc(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)nc3c2)n1 Show InChI InChI=1S/C24H26ClN7O2/c1-26-23-27-8-7-22(30-23)33-18-4-6-21-20(14-18)29-24(34-21)28-17-3-5-19(25)16(13-17)15-32-11-9-31(2)10-12-32/h3-8,13-14H,9-12,15H2,1-2H3,(H,28,29)(H,26,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222504 (CHEMBL249192 | ethyl 5-(3-(2-(pyridin-4-ylmethylam...) Show SMILES CCOC(=O)c1coc(c1)-c1cccc(NC(=O)c2cccnc2NCc2ccncc2)c1 Show InChI InChI=1S/C25H22N4O4/c1-2-32-25(31)19-14-22(33-16-19)18-5-3-6-20(13-18)29-24(30)21-7-4-10-27-23(21)28-15-17-8-11-26-12-9-17/h3-14,16H,2,15H2,1H3,(H,27,28)(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222508 (2-(benzo[d][1,3]dioxol-5-ylmethylamino)-N-(4-pheno...) Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)c1cccnc1NCc1ccc2OCOc2c1 Show InChI InChI=1S/C26H21N3O4/c30-26(29-19-9-11-21(12-10-19)33-20-5-2-1-3-6-20)22-7-4-14-27-25(22)28-16-18-8-13-23-24(15-18)32-17-31-23/h1-15H,16-17H2,(H,27,28)(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17692 (2-aminobenzimidazole, 17 | N-{4-chloro-3-[(4-methy...) Show SMILES CNc1nccc(Oc2ccc3nc(Nc4ccc(Cl)c(CN5CCN(C)CC5)c4)[nH]c3c2)n1 Show InChI InChI=1S/C24H27ClN8O/c1-26-23-27-8-7-22(31-23)34-18-4-6-20-21(14-18)30-24(29-20)28-17-3-5-19(25)16(13-17)15-33-11-9-32(2)10-12-33/h3-8,13-14H,9-12,15H2,1-2H3,(H,26,27,31)(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	40	-41.8	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM17681 (2-aminobenzimidazole, 6 | N-[4-chloro-3-(trifluoro...) Show SMILES FC(F)(F)c1cc(Nc2nc3ccc(Oc4ccnc5[nH]ccc45)cc3[nH]2)ccc1Cl Show InChI InChI=1S/C21H13ClF3N5O/c22-15-3-1-11(9-14(15)21(23,24)25)28-20-29-16-4-2-12(10-17(16)30-20)31-18-6-8-27-19-13(18)5-7-26-19/h1-10H,(H,26,27)(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	48	-41.4	n/a	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...				J Med Chem 50: 4351-4373 (2007) Article DOI: 10.1021/jm070034i BindingDB Entry DOI: 10.7270/Q21V5C74
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222496 (2-(1H-indazol-6-ylamino)-N-(4-phenoxyphenyl)nicoti...) Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)c1cccnc1Nc1ccc2cn[nH]c2c1 Show InChI InChI=1S/C25H19N5O2/c31-25(29-18-10-12-21(13-11-18)32-20-5-2-1-3-6-20)22-7-4-14-26-24(22)28-19-9-8-17-16-27-30-23(17)15-19/h1-16H,(H,26,28)(H,27,30)(H,29,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222507 (CHEMBL399546 | N-biphenyl-3-yl-2-[(pyridin-4-ylmet...) Show SMILES O=C(Nc1cccc(c1)-c1ccccc1)c1cccnc1NCc1ccncc1 Show InChI InChI=1S/C24H20N4O/c29-24(28-21-9-4-8-20(16-21)19-6-2-1-3-7-19)22-10-5-13-26-23(22)27-17-18-11-14-25-15-12-18/h1-16H,17H2,(H,26,27)(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	91	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50222520 (CHEMBL248980 | N-(3-ethylphenyl)-2-(pyridin-4-ylme...) Show SMILES CCc1cccc(NC(=O)c2cccnc2NCc2ccncc2)c1 Show InChI InChI=1S/C20H20N4O/c1-2-15-5-3-6-17(13-15)24-20(25)18-7-4-10-22-19(18)23-14-16-8-11-21-12-9-16/h3-13H,2,14H2,1H3,(H,22,23)(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	106	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Curated by ChEMBL					Assay Description Inhibition of phosphorylated-Kdr after 30 mins				Bioorg Med Chem Lett 17: 6003-8 (2007) Article DOI: 10.1016/j.bmcl.2007.07.077 BindingDB Entry DOI: 10.7270/Q27P8Z3N
					More data for this Ligand-Target Pair

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