Found 13 hits with Last Name = 'briggs' and Initial = 'gm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50407402
(CHEMBL2093896)Show SMILES CSc1ccc(cc1)[C@H]1N=C(OCc2ccc(NS(C)(=O)=O)cc2)N(C)Cc2ccccc12 |r,t:10| Show InChI InChI=1S/C25H27N3O3S2/c1-28-16-20-6-4-5-7-23(20)24(19-10-14-22(32-2)15-11-19)26-25(28)31-17-18-8-12-21(13-9-18)27-33(3,29)30/h4-15,24,27H,16-17H2,1-3H3/t24-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50407403
(CHEMBL2092889)Show SMILES CN1Cc2ccccc2[C@@H](N=C1OCc1ccc(NS(C)(=O)=O)cc1)c1ccccc1 |r,c:11| Show InChI InChI=1S/C24H25N3O3S/c1-27-16-20-10-6-7-11-22(20)23(19-8-4-3-5-9-19)25-24(27)30-17-18-12-14-21(15-13-18)26-31(2,28)29/h3-15,23,26H,16-17H2,1-2H3/t23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50407402
(CHEMBL2093896)Show SMILES CSc1ccc(cc1)[C@H]1N=C(OCc2ccc(NS(C)(=O)=O)cc2)N(C)Cc2ccccc12 |r,t:10| Show InChI InChI=1S/C25H27N3O3S2/c1-28-16-20-6-4-5-7-23(20)24(19-10-14-22(32-2)15-11-19)26-25(28)31-17-18-8-12-21(13-9-18)27-33(3,29)30/h4-15,24,27H,16-17H2,1-3H3/t24-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1) |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50407402
(CHEMBL2093896)Show SMILES CSc1ccc(cc1)[C@H]1N=C(OCc2ccc(NS(C)(=O)=O)cc2)N(C)Cc2ccccc12 |r,t:10| Show InChI InChI=1S/C25H27N3O3S2/c1-28-16-20-6-4-5-7-23(20)24(19-10-14-22(32-2)15-11-19)26-25(28)31-17-18-8-12-21(13-9-18)27-33(3,29)30/h4-15,24,27H,16-17H2,1-3H3/t24-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1) |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50407403
(CHEMBL2092889)Show SMILES CN1Cc2ccccc2[C@@H](N=C1OCc1ccc(NS(C)(=O)=O)cc1)c1ccccc1 |r,c:11| Show InChI InChI=1S/C24H25N3O3S/c1-27-16-20-10-6-7-11-22(20)23(19-8-4-3-5-9-19)25-24(27)30-17-18-12-14-21(15-13-18)26-31(2,28)29/h3-15,23,26H,16-17H2,1-2H3/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1) |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50407404
(CHEMBL2092890)Show SMILES CN1Cc2ccccc2[C@H](N=C1CCc1ccc(NS(C)(=O)=O)cc1)c1ccc(F)cc1F |r,c:11| Show InChI InChI=1S/C25H25F2N3O2S/c1-30-16-18-5-3-4-6-21(18)25(22-13-10-19(26)15-23(22)27)28-24(30)14-9-17-7-11-20(12-8-17)29-33(2,31)32/h3-8,10-13,15,25,29H,9,14,16H2,1-2H3/t25-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50369030
(CHEMBL1788206)Show SMILES CN1Cc2ccccc2[C@H](N=C1OCc1ccc(NS(C)(=O)=O)cc1)c1ccccc1 |r,c:11| Show InChI InChI=1S/C24H25N3O3S/c1-27-16-20-10-6-7-11-22(20)23(19-8-4-3-5-9-19)25-24(27)30-17-18-12-14-21(15-13-18)26-31(2,28)29/h3-15,23,26H,16-17H2,1-2H3/t23-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50031720
((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)Show SMILES CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 Show InChI InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
| DrugBank PubMed
| n/a | n/a | 4.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50369029
(CHEMBL1788304)Show SMILES CN1Cc2ccccc2[C@@H](N=C1CCc1ccc(NS(C)(=O)=O)cc1)c1ccc(F)cc1F |r,c:11| Show InChI InChI=1S/C25H25F2N3O2S/c1-30-16-18-5-3-4-6-21(18)25(22-13-10-19(26)15-23(22)27)28-24(30)14-9-17-7-11-20(12-8-17)29-33(2,31)32/h3-8,10-13,15,25,29H,9,14,16H2,1-2H3/t25-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 8.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of the delayed rectifier K+ current (IKr) of guinea pig myocytes |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50407404
(CHEMBL2092890)Show SMILES CN1Cc2ccccc2[C@H](N=C1CCc1ccc(NS(C)(=O)=O)cc1)c1ccc(F)cc1F |r,c:11| Show InChI InChI=1S/C25H25F2N3O2S/c1-30-16-18-5-3-4-6-21(18)25(22-13-10-19(26)15-23(22)27)28-24(30)14-9-17-7-11-20(12-8-17)29-33(2,31)32/h3-8,10-13,15,25,29H,9,14,16H2,1-2H3/t25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1) |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50369029
(CHEMBL1788304)Show SMILES CN1Cc2ccccc2[C@@H](N=C1CCc1ccc(NS(C)(=O)=O)cc1)c1ccc(F)cc1F |r,c:11| Show InChI InChI=1S/C25H25F2N3O2S/c1-30-16-18-5-3-4-6-21(18)25(22-13-10-19(26)15-23(22)27)28-24(30)14-9-17-7-11-20(12-8-17)29-33(2,31)32/h3-8,10-13,15,25,29H,9,14,16H2,1-2H3/t25-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1) |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50369030
(CHEMBL1788206)Show SMILES CN1Cc2ccccc2[C@H](N=C1OCc1ccc(NS(C)(=O)=O)cc1)c1ccccc1 |r,c:11| Show InChI InChI=1S/C24H25N3O3S/c1-27-16-20-10-6-7-11-22(20)23(19-8-4-3-5-9-19)25-24(27)30-17-18-12-14-21(15-13-18)26-31(2,28)29/h3-15,23,26H,16-17H2,1-2H3/t23-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.26E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1) |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50031720
((Dofetilide) N-[4-(2-{[2-(4-Methanesulfonylamino-p...)Show SMILES CN(CCOc1ccc(NS(C)(=O)=O)cc1)CCc1ccc(NS(C)(=O)=O)cc1 Show InChI InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
| PubMed
| n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Sterling Winthrop Research
Curated by ChEMBL
| Assay Description Blockade of Na+ current in frog oocytes expressing human cardiac sodium channel (HH1) |
J Med Chem 38: 2551-6 (1995)
BindingDB Entry DOI: 10.7270/Q2H132N3 |
More data for this Ligand-Target Pair | |