Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM412656 (US10399974, Example 54) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | Article PubMed | 0.0470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM241208 (US11046688, Example 50 | US9409907, 50) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0840 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM50464039 (CHEMBL4245639) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM241333 (US10479788, Example 177 | US11046688, Example 177 ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0940 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM241338 (US10479788, Example 182 | US11046688, Example 182 ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM412611 (N-(2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)phen...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | Article PubMed | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM412614 (N2-(4-(4,5-dimethyl-4H-1,2,4-triazol-3-yl)-2-ethox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | Article PubMed | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM50464037 (CHEMBL4240502) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM241335 (US9409907, 179) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM50464040 (CHEMBL4251352) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM412610 (1-(2-((2-ethoxy-4-(4-methyl-4H-1,2,4-triazol-3-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM50464038 (CHEMBL4250961) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM241226 (US10479788, Example 68 | US11046688, Example 68 | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM241207 (US11046688, Example 49 | US9409907, 49) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.780 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM412658 (US10399974, Example 56) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | Article PubMed | 0.820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM412644 (US10399974, Example 42) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | UniChem | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304836 (1,2-dimethyl-4-(6-methylpyridin-2-yl)-5-(quinoxali...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304849 (4-(3-ethylphenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM241331 (US10479788, Example 175 | US11046688, Example 175 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304835 (1,2-dimethyl-4-(pyridin-2-yl)-5-(quinoxalin-6-yl)-...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304850 (1,2-dimethyl-5-(quinoxalin-6-yl)-4-(3-vinylphenyl)...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304864 (4-(3-bromophenyl)-1,2-dimethyl-5-(quinoxalin-6-yl)...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50110208 (4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304863 (4-(3-chlorophenyl)-1,2-dimethyl-5-(quinoxalin-6-yl...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304865 (CHEMBL607429 | N-(3-(1,2-dimethyl-3-oxo-5-(quinoxa...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304840 (1,2-dimethyl-5-(quinoxalin-6-yl)-4-m-tolyl-1H-pyra...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304853 (4-(3-methoxyphenyl)-1,2-dimethyl-5-(quinoxalin-6-y...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity protein kinase TTK (Homo sapiens (Human)) | BDBM241206 (US11046688, Example 48 | US9409907, 48) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal 6xHis-tagged MPS1 expressed in baculovirus expression system using 5FAM-H236 peptide as substrate after 60... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304858 (2-(3-(1,2-dimethyl-3-oxo-5-(quinoxalin-6-yl)-2,3-d...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304855 (4-(3-(methoxymethyl)phenyl)-1,2-dimethyl-5-(quinox...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM241208 (US11046688, Example 50 | US9409907, 50) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 43 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304872 (1,2-dimethyl-5-(quinoxalin-6-yl)-4-(thiophen-3-yl)...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304852 (1,2-dimethyl-4-(3-(methylthio)phenyl)-5-(quinoxali...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM241335 (US9409907, 179) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304870 (4-(furan-3-yl)-1,2-dimethyl-5-(quinoxalin-6-yl)-1H...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM412656 (US10399974, Example 54) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | UniChem | Article PubMed | 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304839 (1,2-dimethyl-4-phenyl-5-(quinoxalin-6-yl)-1H-pyraz...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304862 (4-(3-fluorophenyl)-1,2-dimethyl-5-(quinoxalin-6-yl...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304854 (1,2-dimethyl-5-(quinoxalin-6-yl)-4-(3-(trifluorome...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 111 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM50464040 (CHEMBL4251352) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM50464037 (CHEMBL4240502) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304869 (4-(furan-2-yl)-1,2-dimethyl-5-(quinoxalin-6-yl)-1H...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM241226 (US10479788, Example 68 | US11046688, Example 68 | ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | 230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304871 (1,2-dimethyl-5-(quinoxalin-6-yl)-4-(thiophen-2-yl)...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 365 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304856 (4-(3-(hydroxymethyl)phenyl)-1,2-dimethyl-5-(quinox...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304859 (4-(3-acetylphenyl)-1,2-dimethyl-5-(quinoxalin-6-yl...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 410 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50304861 (CHEMBL593950 | methyl 3-(1,2-dimethyl-3-oxo-5-(qui...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 440 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Biogen Idec Inc. Curated by ChEMBL | Assay Description Displacement of [3H]HTS446284 from human recombinant His-tagged TGFbetaR1 after 1 hr by scintillation counting | Bioorg Med Chem Lett 20: 326-9 (2010) Article DOI: 10.1016/j.bmcl.2009.10.108 BindingDB Entry DOI: 10.7270/Q2RN37ZK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM412614 (N2-(4-(4,5-dimethyl-4H-1,2,4-triazol-3-yl)-2-ethox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | UniChem | Article PubMed | 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM241338 (US10479788, Example 182 | US11046688, Example 182 ...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | 510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human)) | BDBM412658 (US10399974, Example 56) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | UniChem | Article PubMed | 550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Inhibition of full length human N-terminal His-tagged CDK2/cyclinA expressed in baculovirus expression system using 5FAM- peptide18 as substrate afte... | J Med Chem 61: 8226-8240 (2018) Article DOI: 10.1021/acs.jmedchem.8b00690 BindingDB Entry DOI: 10.7270/Q2J105S9 | |||||||||||
More data for this Ligand-Target Pair |
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