Compile Data Set for Download or QSAR

Found 1866 hits with Last Name = 'cho' and Initial = 'sy'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM515773 (US11053225, Compound 23) Show SMILES Cn1cc(cn1)-c1cnc(NC23CC4CC(CC(C4)C2)C3)nc1NC1CCCCC1 |TLB:20:11:18:14.15.16,THB:10:11:18:14.15.16,20:15:18:11.19.12,19:11:14:18.17.16,19:17:14:11.20.12| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515838 (US11053225, Compound 139) Show SMILES Cn1cc(cn1)-c1cnc(Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)nc1Nc1ccc2CCN(Cc2c1)C(=O)C(F)(F)F Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.00600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515828 (US11053225, Compound 129 | US11053225, Compound 19...) Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cccc(Cl)c2Cl)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515870 (US11053225, Compound 172) Show SMILES CCCn1cc(cn1)-c1cnc(Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515820 (US11053225, Compound 101 | US11053225, Compound 19...) Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cccc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515810 (US11053225, Compound 201) Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc(cc1)C1CCNCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515869 (US11053225, Compound 171) Show SMILES CCCn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515814 (US11053225, Compound 84) Show SMILES Cn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0410	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515817 (US11053225, Compound 89) Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0410	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515826 (US11053225, Compound 127) Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0520	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515794 (US11053225, Compound 75) Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1NC1CCNCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515836 (US11053225, Compound 137) Show SMILES Cn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0970	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515865 (US11053225, Compound 167) Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cccc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM515786 (US11053225, Compound 69) Show SMILES COc1ccc(cc1OC)-c1cnc(Nc2cccc(Cl)c2)nc1NC1CCN(CC1)C(=O)C(F)(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515846 (US11053225, Compound 147) Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515871 (US11053225, Compound 173) Show SMILES CCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515847 (US11053225, Compound 148) Show SMILES COc1cc(Nc2ncc(-c3cnn(CCO)c3)c(Nc3ccc4CCNCc4c3)n2)cc(c1)C(F)(F)F Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515860 (US11053225, Compound 162) Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515812 (US11053225, Compound 205) Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc(cc1)C1CCNCC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515879 (US11053225, Compound 181) Show SMILES CC(C)Cn1cc(cn1)-c1cnc(Nc2cc(F)cc(F)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515830 (US11053225, Compound 131) Show SMILES Fc1cc(F)cc(Nc2ncc(-c3cnn(c3)C3CCNCC3)c(Nc3ccc4CCNCc4c3)n2)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515858 (US11053225, Compound 160) Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515867 (US11053225, Compound 169) Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cccc(C)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515877 (US11053225, Compound 179) Show SMILES CC(C)Cn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515857 (US11053225, Compound 159) Show SMILES Cc1ccc(F)cc1Nc1ncc(-c2cnn(C)c2)c(Nc2ccc3CCNCc3c2)n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515799 (US11053225, Compound 103) Show SMILES N[C@H]1CC[C@H](CC1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1-c1cnn(CCO)c1 |r,wU:4.7,1.0,(5.92,3.85,;4.58,3.08,;4.58,1.54,;3.25,.77,;1.92,1.54,;1.92,3.08,;3.25,3.85,;.58,.77,;.58,-.77,;1.92,-1.54,;1.92,-3.08,;3.25,-3.85,;4.58,-3.08,;5.92,-3.85,;7.25,-3.08,;8.59,-3.85,;7.25,-1.54,;5.92,-.77,;5.92,.77,;4.58,-1.54,;.58,-3.85,;-.75,-3.08,;-.75,-1.54,;-2.08,-.77,;-2.25,.76,;-3.75,1.08,;-4.52,-.25,;-6.01,-.65,;-7.1,.44,;-8.59,.04,;-3.49,-1.4,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.190	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50384024 (CHEMBL2032280 | CHEMBL2079349) Show SMILES Cc1c(O)ccc2nc(oc12)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1 Show InChI InChI=1S/C21H22N6O2/c1-12-18(28)3-2-17-19(12)29-21(26-17)16-8-13(9-24-20(16)22)14-10-25-27(11-14)15-4-6-23-7-5-15/h2-3,8-11,15,23,28H,4-7H2,1H3,(H2,22,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis				Bioorg Med Chem Lett 22: 4044-8 (2012) Article DOI: 10.1016/j.bmcl.2012.04.083 BindingDB Entry DOI: 10.7270/Q2FF3TC4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM512366 (US11084824, Example 21) Show SMILES CC(C)N1CCc2ccc(Nc3ncc4c(Nc5c(C)cccc5C)nn(C)c4n3)cc2C1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description BTK enzyme evaluation with each compound of examples of the invention was performed by using BTK enzyme inhibition diagnosis kit (Cisbio, Codolet, Fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2NP27KP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515831 (US11053225, Compound 132) Show SMILES Clc1cc(Cl)cc(Nc2ncc(-c3cnn(c3)C3CCNCC3)c(Nc3ccc4CCNCc4c3)n2)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM243386 (5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(7-is...) Show SMILES CC(C)Oc1cc2CNCCc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C25H30ClN5O3S/c1-15(2)34-22-12-18-13-27-10-9-17(18)11-21(22)30-25-28-14-19(26)24(31-25)29-20-7-5-6-8-23(20)35(32,33)16(3)4/h5-8,11-12,14-16,27H,9-10,13H2,1-4H3,(H2,28,29,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	25
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY US Patent					Assay Description A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...				US Patent US10053458 (2018) BindingDB Entry DOI: 10.7270/Q2ZS2ZH9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM515783 (US11053225, Compound 65) Show SMILES COc1ccccc1Nc1ncc(c(NC2CCN(CC2)C(=O)C(F)(F)F)n1)-c1ccc(OC)c(OC)c1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515861 (US11053225, Compound 163) Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cc(F)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.230	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM243402 (5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(6-me...) Show SMILES COc1cc2CCNCc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C23H26ClN5O3S/c1-14(2)33(30,31)21-7-5-4-6-18(21)27-22-17(24)13-26-23(29-22)28-19-10-16-12-25-9-8-15(16)11-20(19)32-3/h4-7,10-11,13-14,25H,8-9,12H2,1-3H3,(H2,26,27,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of crizotinib-resistant ALK G1269A mutant (unknown origin) using peptide substrate incubated for 30 mins in presence of ATP by fluorescenc...				Citation and Details Article DOI: 10.1016/j.bmc.2015.12.004 BindingDB Entry DOI: 10.7270/Q269778Q
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM243393 (5-chloro-N4-2-(isopropylsulfonyl)phenyl)-N2-(7-met...) Show SMILES COc1cc2C(C)NCCc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C24H28ClN5O3S/c1-14(2)34(31,32)22-8-6-5-7-19(22)28-23-18(25)13-27-24(30-23)29-20-11-16-9-10-26-15(3)17(16)12-21(20)33-4/h5-8,11-15,26H,9-10H2,1-4H3,(H2,27,28,29,30)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	25
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY US Patent					Assay Description A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...				US Patent US10053458 (2018) BindingDB Entry DOI: 10.7270/Q2ZS2ZH9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515876 (US11053225, Compound 178) Show SMILES CCCn1cc(cn1)-c1cnc(Nc2cccc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515880 (US11053225, Compound 182) Show SMILES CC(C)Cn1cc(cn1)-c1cnc(Nc2cc(F)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515803 (US11053225, Compound 110) Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cc(Cl)cc(Cl)c2)nc1N[C@H]1CC[C@@H](CC1)NC(=O)C(F)(F)F |r,wU:24.26,wD:27.33,(3.74,-9.89,;4.65,-8.64,;4.02,-7.23,;4.92,-5.99,;4.45,-4.52,;5.69,-3.62,;6.94,-4.52,;6.46,-5.99,;5.69,-2.08,;7.03,-1.31,;7.03,.23,;5.69,1,;5.69,2.54,;4.36,3.31,;3.03,2.54,;1.69,3.31,;.36,2.54,;1.69,4.85,;3.03,5.62,;3.03,7.16,;4.36,4.85,;4.36,.23,;4.36,-1.31,;3.03,-2.08,;1.69,-1.31,;.36,-2.08,;-.97,-1.31,;-.97,.23,;.36,1,;1.69,.23,;-2.31,1,;-2.31,2.54,;-.97,3.31,;-3.64,3.31,;-4.97,4.08,;-2.87,4.65,;-4.41,1.98,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.280	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM512368 (US11084824, Example 23) Show SMILES Cc1cccc(C)c1Nc1nn(C)c2nc(Nc3ccc4CCN(Cc4c3)C(=O)C3CC3)ncc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description BTK enzyme evaluation with each compound of examples of the invention was performed by using BTK enzyme inhibition diagnosis kit (Cisbio, Codolet, Fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2NP27KP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM512369 (US11084824, Example 24) Show SMILES CC1N=C(Nc2c(C)cccc2C)c2cnc(Nc3ccc4CCN(CCO)Cc4c3)nc12 |t:2| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description BTK enzyme evaluation with each compound of examples of the invention was performed by using BTK enzyme inhibition diagnosis kit (Cisbio, Codolet, Fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2NP27KP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515844 (US11053225, Compound 145) Show SMILES Cn1cc(cn1)-c1cnc(Nc2cc(F)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50380974 (CHEMBL2016903) Show SMILES Fc1ccc2[nH]c(=O)c(cc2c1)-c1nc2CCN(Cc2[nH]1)C(=O)c1ccncc1 Show InChI InChI=1S/C21H16FN5O2/c22-14-1-2-16-13(9-14)10-15(20(28)26-16)19-24-17-5-8-27(11-18(17)25-19)21(29)12-3-6-23-7-4-12/h1-4,6-7,9-10H,5,8,11H2,(H,24,25)(H,26,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Chemical Technology Curated by ChEMBL					Assay Description Inhibition of recombinant VEGFR-2 kinase domain by homogeneous time-resolved fluorescence assay				Bioorg Med Chem Lett 22: 2837-42 (2012) Article DOI: 10.1016/j.bmcl.2012.02.073 BindingDB Entry DOI: 10.7270/Q2RN38W3
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor [L1196M] (Homo sapiens (Human))	BDBM243393 (5-chloro-N4-2-(isopropylsulfonyl)phenyl)-N2-(7-met...) Show SMILES COc1cc2C(C)NCCc2cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 Show InChI InChI=1S/C24H28ClN5O3S/c1-14(2)34(31,32)22-8-6-5-7-19(22)28-23-18(25)13-27-24(30-23)29-20-11-16-9-10-26-15(3)17(16)12-21(20)33-4/h5-8,11-15,26H,9-10H2,1-4H3,(H2,27,28,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY US Patent									US Patent US10053458 (2018) BindingDB Entry DOI: 10.7270/Q2ZS2ZH9
					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM243395 (5-chloro-N4-2-(isopropylsulfonyl)phenyl)-N2-(7-met...) Show SMILES CCC1NCCc2cc(Nc3ncc(Cl)c(Nc4ccccc4S(=O)(=O)C(C)C)n3)c(OC)cc12 Show InChI InChI=1S/C25H30ClN5O3S/c1-5-19-17-13-22(34-4)21(12-16(17)10-11-27-19)30-25-28-14-18(26)24(31-25)29-20-8-6-7-9-23(20)35(32,33)15(2)3/h6-9,12-15,19,27H,5,10-11H2,1-4H3,(H2,28,29,30,31)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	25
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY US Patent					Assay Description A proliferation inhibitory activity against the ALK of the compound represented by Chemical Formula 1 according to the present invention at an enzyme...				US Patent US10053458 (2018) BindingDB Entry DOI: 10.7270/Q2ZS2ZH9
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM512364 (Preparation of N3-(2,6-dimethylphenyl)-N6-(1,2,3,4...) Show SMILES Cc1cccc(C)c1Nc1n[nH]c2nc(Nc3ccc4CCNCc4c3)ncc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description BTK enzyme evaluation with each compound of examples of the invention was performed by using BTK enzyme inhibition diagnosis kit (Cisbio, Codolet, Fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2NP27KP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM512370 (US11084824, Example 25) Show SMILES Cc1cccc(C)c1Nc1nn(C2CCCC2)c2nc(Nc3ccc4CCNCc4c3)ncc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description BTK enzyme evaluation with each compound of examples of the invention was performed by using BTK enzyme inhibition diagnosis kit (Cisbio, Codolet, Fr...				Citation and Details BindingDB Entry DOI: 10.7270/Q2NP27KP
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515873 (US11053225, Compound 175) Show SMILES CCCn1cc(cn1)-c1cnc(Nc2cc(F)cc(Cl)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515864 (US11053225, Compound 166) Show SMILES CC(C)n1cc(cn1)-c1cnc(Nc2cc(C)cc(C)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515854 (US11053225, Compound 156) Show SMILES Cc1ccccc1Nc1ncc(-c2cnn(C)c2)c(Nc2ccc3CCNCc3c2)n1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM515821 (US11053225, Compound 102) Show SMILES OCCn1cc(cn1)-c1cnc(Nc2cccc(F)c2)nc1Nc1ccc2CCNCc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM515805 (US11053225, Compound 113) Show SMILES N[C@H]1CC[C@@H](CC1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)ncc1-c1cnn(CCO)c1 |r,wU:1.0,wD:4.7,(5.88,3.85,;4.55,3.08,;4.55,1.54,;3.22,.77,;1.88,1.54,;1.88,3.08,;3.22,3.85,;.55,.77,;.55,-.77,;1.88,-1.54,;1.88,-3.08,;3.22,-3.85,;4.55,-3.08,;5.88,-3.85,;7.22,-3.08,;8.55,-3.85,;7.22,-1.54,;5.88,-.77,;5.88,.77,;4.55,-1.54,;.55,-3.85,;-.78,-3.08,;-.78,-1.54,;-2.12,-.77,;-2.12,.77,;-3.58,1.25,;-4.49,,;-5.98,-.4,;-7.06,.69,;-8.55,.29,;-3.58,-1.25,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.370	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description For evaluation of inhibitory activities of the compounds according to the present invention on Tyro 3, Axl, and Mer, the following test was carried o...				Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2DST
					More data for this Ligand-Target Pair

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