Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50436850 (CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of ALK (unknown origin) after 60 mins | J Med Chem 56: 5675-90 (2014) Article DOI: 10.1021/jm400402q BindingDB Entry DOI: 10.7270/Q2G1627J | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
BDNF/NT-3 growth factors receptor (Homo sapiens (Human)) | BDBM50092079 (CHEMBL3582439) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092079 (CHEMBL3582439) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDNF/NT-3 growth factors receptor (Homo sapiens (Human)) | BDBM50092082 (CHEMBL3582441) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50092082 (CHEMBL3582441) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKA (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50092082 (CHEMBL3582441) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of NGF-activated full length TRKA (unknown origin) expressed in mouse BA/F3 cells assessed as inhibition of cell proliferation | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50092082 (CHEMBL3582441) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of TPM3-fused TRKA (unknown origin) expressed in human KM12 cells assessed as inhibition of cell proliferation after 48 hrs by luciferase ... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092082 (CHEMBL3582441) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092081 (CHEMBL3582442) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092132 (CHEMBL3582440) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50436850 (CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of EML4-fused ALK (unknown origin) by cell-based assay | J Med Chem 56: 5675-90 (2014) Article DOI: 10.1021/jm400402q BindingDB Entry DOI: 10.7270/Q2G1627J | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092085 (CHEMBL3582438) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092104 (CHEMBL3582432) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50092079 (CHEMBL3582439) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKA (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50092081 (CHEMBL3582442) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of NGF-activated full length TRKA (unknown origin) expressed in mouse BA/F3 cells assessed as inhibition of cell proliferation | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM482158 (BDBM50242742 | TAE684) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay | J Med Chem 56: 5675-90 (2014) Article DOI: 10.1021/jm400402q BindingDB Entry DOI: 10.7270/Q2G1627J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDNF/NT-3 growth factors receptor (Homo sapiens (Human)) | BDBM50092132 (CHEMBL3582440) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092086 (CHEMBL3582433) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50092081 (CHEMBL3582442) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKA (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDNF/NT-3 growth factors receptor (Homo sapiens (Human)) | BDBM50092081 (CHEMBL3582442) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM482158 (BDBM50242742 | TAE684) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused ALK kinase-mediated mouse BaF3 cell proliferation | Proc Natl Acad Sci U S A 104: 270-5 (2007) Article DOI: 10.1073/pnas.0609412103 BindingDB Entry DOI: 10.7270/Q2BP02K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50092132 (CHEMBL3582440) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKA (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50092104 (CHEMBL3582432) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKA (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092090 (CHEMBL3582429) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin receptor (Homo sapiens (Human)) | BDBM50436850 (CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of insulin receptor (unknown origin) after 60 mins | J Med Chem 56: 5675-90 (2014) Article DOI: 10.1021/jm400402q BindingDB Entry DOI: 10.7270/Q2G1627J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin-linked protein kinase (Homo sapiens (Human)) | BDBM123945 (US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | 40 |
Dermira (Canada), Inc. US Patent | Assay Description 5 uL of each compound dilution were robotically pipetted to Costar serocluster plates maintaining the same plate layout. All assay mixtures consisted... | US Patent US8754233 (2014) BindingDB Entry DOI: 10.7270/Q23N2231 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDNF/NT-3 growth factors receptor (Homo sapiens (Human)) | BDBM50092104 (CHEMBL3582432) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092083 (CHEMBL3582436) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin-like growth factor 1 receptor (Homo sapiens (Human)) | BDBM50436850 (CERITINIB | CHEMBL2403108 | LDK378 | US10053458, C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of IGF1 receptor (unknown origin) after 60 mins | J Med Chem 56: 5675-90 (2014) Article DOI: 10.1021/jm400402q BindingDB Entry DOI: 10.7270/Q2G1627J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50436863 (CHEMBL2403836) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay | J Med Chem 56: 5675-90 (2014) Article DOI: 10.1021/jm400402q BindingDB Entry DOI: 10.7270/Q2G1627J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM482158 (BDBM50242742 | TAE684) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Decrease in ALK phosphorylation in human SUDHL1 cells after 4 hrs | Proc Natl Acad Sci U S A 104: 270-5 (2007) Article DOI: 10.1073/pnas.0609412103 BindingDB Entry DOI: 10.7270/Q2BP02K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM482158 (BDBM50242742 | TAE684) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Decrease in ALK phosphorylation in human Karpas299 cells after 4 hrs | Proc Natl Acad Sci U S A 104: 270-5 (2007) Article DOI: 10.1073/pnas.0609412103 BindingDB Entry DOI: 10.7270/Q2BP02K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Mus musculus) | BDBM482158 (BDBM50242742 | TAE684) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Decrease in ALK phosphorylation in mouse Ba/F3 NPM-ALK cells after 4 hrs | Proc Natl Acad Sci U S A 104: 270-5 (2007) Article DOI: 10.1073/pnas.0609412103 BindingDB Entry DOI: 10.7270/Q2BP02K2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin-linked protein kinase (Homo sapiens (Human)) | BDBM124052 (US8754233, 5-(3-Amino-propyl)-4-benzothiazol-2-yl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | 40 |
Dermira (Canada), Inc. US Patent | Assay Description 5 uL of each compound dilution were robotically pipetted to Costar serocluster plates maintaining the same plate layout. All assay mixtures consisted... | US Patent US8754233 (2014) BindingDB Entry DOI: 10.7270/Q23N2231 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin-linked protein kinase (Homo sapiens (Human)) | BDBM123951 (US8754233, 2-(5-Amino-3-methyl-1H-pyrazol-4-yl)-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | 40 |
Dermira (Canada), Inc. US Patent | Assay Description 5 uL of each compound dilution were robotically pipetted to Costar serocluster plates maintaining the same plate layout. All assay mixtures consisted... | US Patent US8754233 (2014) BindingDB Entry DOI: 10.7270/Q23N2231 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50092081 (CHEMBL3582442) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of TPM3-fused TRKA (unknown origin) expressed in human KM12 cells assessed as inhibition of cell proliferation after 48 hrs by luciferase ... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50436862 (CHEMBL2403845) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay | J Med Chem 56: 5675-90 (2014) Article DOI: 10.1021/jm400402q BindingDB Entry DOI: 10.7270/Q2G1627J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092088 (CHEMBL3582434) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDNF/NT-3 growth factors receptor (Homo sapiens (Human)) | BDBM50092085 (CHEMBL3582438) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50436861 (CHEMBL2403849) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay | J Med Chem 56: 5675-90 (2014) Article DOI: 10.1021/jm400402q BindingDB Entry DOI: 10.7270/Q2G1627J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDNF/NT-3 growth factors receptor (Homo sapiens (Human)) | BDBM50092086 (CHEMBL3582433) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50436860 (CHEMBL2403843) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay | J Med Chem 56: 5675-90 (2014) Article DOI: 10.1021/jm400402q BindingDB Entry DOI: 10.7270/Q2G1627J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50436858 (CHEMBL2403848) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay | J Med Chem 56: 5675-90 (2014) Article DOI: 10.1021/jm400402q BindingDB Entry DOI: 10.7270/Q2G1627J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM50436859 (CHEMBL2403841) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells after 2 to 3 days by luciferase reporter gene assay | J Med Chem 56: 5675-90 (2014) Article DOI: 10.1021/jm400402q BindingDB Entry DOI: 10.7270/Q2G1627J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092089 (CHEMBL3582435) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin-linked protein kinase (Homo sapiens (Human)) | BDBM124022 (US8754233, 4-Benzothiazol-2-yl-5-(3-methylamino-pr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | 40 |
Dermira (Canada), Inc. US Patent | Assay Description 5 uL of each compound dilution were robotically pipetted to Costar serocluster plates maintaining the same plate layout. All assay mixtures consisted... | US Patent US8754233 (2014) BindingDB Entry DOI: 10.7270/Q23N2231 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NT-3 growth factor receptor (Homo sapiens (Human)) | BDBM50092087 (CHEMBL3580682) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin-linked protein kinase (Homo sapiens (Human)) | BDBM124067 (US8754233, N3-(2-Amino-ethyl)-4-benzothiazol-2-yl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | 40 |
Dermira (Canada), Inc. US Patent | Assay Description 5 uL of each compound dilution were robotically pipetted to Costar serocluster plates maintaining the same plate layout. All assay mixtures consisted... | US Patent US8754233 (2014) BindingDB Entry DOI: 10.7270/Q23N2231 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrin-linked protein kinase (Homo sapiens (Human)) | BDBM123930 (US8754233, 2-(3-Amino-1H-pyrazol-4-yl)-5-fluoro-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | 40 |
Dermira (Canada), Inc. US Patent | Assay Description 5 uL of each compound dilution were robotically pipetted to Costar serocluster plates maintaining the same plate layout. All assay mixtures consisted... | US Patent US8754233 (2014) BindingDB Entry DOI: 10.7270/Q23N2231 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BDNF/NT-3 growth factors receptor (Homo sapiens (Human)) | BDBM50092090 (CHEMBL3582429) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer... | ACS Med Chem Lett 6: 562-7 (2015) Article DOI: 10.1021/acsmedchemlett.5b00050 BindingDB Entry DOI: 10.7270/Q2TM7CW4 | |||||||||||
More data for this Ligand-Target Pair |
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