Found 108 hits with Last Name = 'clagett-dame' and Initial = 'm' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50388434
(CHEMBL605525)Show SMILES [#6]-[#6@@H](-[#6]-[#6]-[#6]C([#6])([#6])[#8])-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1\[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)22-12-13-23-21(9-7-15-27(22,23)5)11-10-20-16-24(28)19(2)25(29)17-20/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b21-11+/t18-,22+,23-,24+,25+,27+/m0/s1 | PDB MMDB
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| 0.00700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription... |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417515
(CHEMBL1630755)Show SMILES [#6]-[#6@@H](-[#8])-[#6]-[#6]-[#6]-[#6@H](-[#6])-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C26H42O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-18,22-25,27-29H,3,5-9,12-16H2,1-2,4H3/b21-11+/t17-,18+,22+,23-,24+,25+,26+/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription... |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50388439
(CHEMBL2059272)Show SMILES [#6]-[#6@@H](-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1)C([#6])([#6])[#6]-[#6]C([#6])([#6])[#8] |r| Show InChI InChI=1S/C29H48O3/c1-19-25(30)17-21(18-26(19)31)10-11-22-9-8-14-29(7)23(12-13-24(22)29)20(2)27(3,4)15-16-28(5,6)32/h10-11,20,23-26,30-32H,1,8-9,12-18H2,2-7H3/b22-11+/t20-,23+,24-,25+,26+,29+/m0/s1 | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]-1alpha,25(OH)2D3 from recombinant rat VDR after overnight incubation by scintillation counting |
J Med Chem 55: 4352-66 (2012)
Article DOI: 10.1021/jm300187x BindingDB Entry DOI: 10.7270/Q2PK0H71 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417519
(CHEMBL1630759)Show SMILES C[C@@H](O)CCC[C@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1 |r,wU:22.24,11.10,16.18,8.7,6.6,1.1,wD:26.28,(1.96,-41.79,;.6,-42.52,;.6,-44.06,;-.7,-41.71,;-2.06,-42.44,;-3.37,-41.62,;-4.73,-42.35,;-6.07,-41.6,;-4.71,-43.89,;-3.82,-45.14,;-4.73,-46.37,;-6.18,-45.89,;-7.5,-46.66,;-8.85,-45.89,;-8.84,-44.35,;-7.5,-43.58,;-6.17,-44.36,;-6.18,-42.82,;-7.5,-48.2,;-8.84,-48.97,;-8.84,-50.51,;-7.51,-51.29,;-7.51,-52.83,;-6.17,-53.6,;-8.84,-53.59,;-8.84,-55.13,;-10.17,-52.83,;-11.51,-53.6,;-10.17,-51.29,)| Show InChI InChI=1S/C26H44O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-19,22-25,27-29H,5-9,12-16H2,1-4H3/b20-10-,21-11+/t17-,18+,19?,22+,23-,24+,25+,26+/m0/s1 | PDB MMDB
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| Article PubMed
| 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription... |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50304585
((20S)-1alpha,25-Dihydroxy-2-methylene-18,19-dinorv...)Show SMILES [#6]-[#6@@H](-[#6]-[#6]-[#6]C([#6])([#6])[#8])-[#6@H]-1-[#6]-[#6]-[#6@@H]2-[#6@@H]-1-[#6]-[#6]-[#6]\[#6]-2=[#6]/[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C26H42O3/c1-17(7-6-14-26(3,4)29)21-12-13-22-20(8-5-9-23(21)22)11-10-19-15-24(27)18(2)25(28)16-19/h10-11,17,21-25,27-29H,2,5-9,12-16H2,1,3-4H3/b20-11+/t17-,21+,22-,23+,24+,25+/m0/s1 | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of radiolabeled 1alpha,25-(OH)2D3 from rat recombinant full length VDR |
Bioorg Med Chem 17: 7658-69 (2009)
Article DOI: 10.1016/j.bmc.2009.09.047 BindingDB Entry DOI: 10.7270/Q26T0MQM |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50388440
(CHEMBL2059269)Show SMILES [#6]-[#6@H](-[#6]-[#6]C([#6])([#6])[#8])-[#6@H](-[#6])-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C28H46O3/c1-18(13-15-27(4,5)31)19(2)23-11-12-24-22(8-7-14-28(23,24)6)10-9-21-16-25(29)20(3)26(30)17-21/h9-10,18-19,23-26,29-31H,3,7-8,11-17H2,1-2,4-6H3/b22-10+/t18-,19+,23-,24+,25-,26-,28-/m1/s1 | PDB MMDB
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| 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]-1alpha,25(OH)2D3 from recombinant rat VDR after overnight incubation by scintillation counting |
J Med Chem 55: 4352-66 (2012)
Article DOI: 10.1021/jm300187x BindingDB Entry DOI: 10.7270/Q2PK0H71 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50200182
((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)Show SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r| Show InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1 | PDB MMDB
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| 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
Bioorg Med Chem 16: 8563-73 (2008)
Article DOI: 10.1016/j.bmc.2008.08.011 BindingDB Entry DOI: 10.7270/Q20001X4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417520
(CHEMBL1630753)Show SMILES C[C@H](O)CCC[C@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C(=C)[C@H](O)C1=C |r| Show InChI InChI=1S/C27H42O3/c1-17(8-6-9-18(2)28)23-13-14-24-21(10-7-15-27(23,24)5)11-12-22-16-25(29)20(4)26(30)19(22)3/h11-12,17-18,23-26,28-30H,3-4,6-10,13-16H2,1-2,5H3/b21-11+,22-12-/t17-,18-,23+,24-,25+,26+,27+/m0/s1 | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50388438
(CHEMBL2059271)Show SMILES [#6]-[#6@H](-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1)C([#6])([#6])[#6]-[#6]C([#6])([#6])[#8] |r| Show InChI InChI=1S/C29H48O3/c1-19-25(30)17-21(18-26(19)31)10-11-22-9-8-14-29(7)23(12-13-24(22)29)20(2)27(3,4)15-16-28(5,6)32/h10-11,20,23-26,30-32H,1,8-9,12-18H2,2-7H3/b22-11+/t20-,23-,24+,25-,26-,29-/m1/s1 | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]-1alpha,25(OH)2D3 from recombinant rat VDR after overnight incubation by scintillation counting |
J Med Chem 55: 4352-66 (2012)
Article DOI: 10.1021/jm300187x BindingDB Entry DOI: 10.7270/Q2PK0H71 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417520
(CHEMBL1630753)Show SMILES C[C@H](O)CCC[C@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C(=C)[C@H](O)C1=C |r| Show InChI InChI=1S/C27H42O3/c1-17(8-6-9-18(2)28)23-13-14-24-21(10-7-15-27(23,24)5)11-12-22-16-25(29)20(4)26(30)19(22)3/h11-12,17-18,23-26,28-30H,3-4,6-10,13-16H2,1-2,5H3/b21-11+,22-12-/t17-,18-,23+,24-,25+,26+,27+/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription... |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417519
(CHEMBL1630759)Show SMILES C[C@@H](O)CCC[C@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1 |r,wU:22.24,11.10,16.18,8.7,6.6,1.1,wD:26.28,(1.96,-41.79,;.6,-42.52,;.6,-44.06,;-.7,-41.71,;-2.06,-42.44,;-3.37,-41.62,;-4.73,-42.35,;-6.07,-41.6,;-4.71,-43.89,;-3.82,-45.14,;-4.73,-46.37,;-6.18,-45.89,;-7.5,-46.66,;-8.85,-45.89,;-8.84,-44.35,;-7.5,-43.58,;-6.17,-44.36,;-6.18,-42.82,;-7.5,-48.2,;-8.84,-48.97,;-8.84,-50.51,;-7.51,-51.29,;-7.51,-52.83,;-6.17,-53.6,;-8.84,-53.59,;-8.84,-55.13,;-10.17,-52.83,;-11.51,-53.6,;-10.17,-51.29,)| Show InChI InChI=1S/C26H44O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-19,22-25,27-29H,5-9,12-16H2,1-4H3/b20-10-,21-11+/t17-,18+,19?,22+,23-,24+,25+,26+/m0/s1 | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417517
(CHEMBL1630757)Show SMILES C[C@H](O)CCC[C@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1 |r,wU:22.24,11.10,16.18,8.7,6.6,wD:26.28,1.1,(14.49,-28.73,;13.13,-29.45,;13.13,-30.99,;11.83,-28.64,;10.47,-29.37,;9.16,-28.56,;7.8,-29.29,;6.46,-28.53,;7.82,-30.83,;8.71,-32.07,;7.8,-33.31,;6.35,-32.82,;5.03,-33.59,;3.68,-32.83,;3.69,-31.28,;5.03,-30.51,;6.36,-31.29,;6.35,-29.75,;5.03,-35.13,;3.69,-35.9,;3.69,-37.44,;5.02,-38.22,;5.02,-39.76,;6.36,-40.53,;3.69,-40.52,;3.69,-42.06,;2.36,-39.76,;1.03,-40.53,;2.36,-38.22,)| Show InChI InChI=1S/C26H44O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-19,22-25,27-29H,5-9,12-16H2,1-4H3/b20-10-,21-11+/t17-,18-,19?,22+,23-,24+,25+,26+/m0/s1 | PDB MMDB
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University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription... |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417515
(CHEMBL1630755)Show SMILES [#6]-[#6@@H](-[#8])-[#6]-[#6]-[#6]-[#6@H](-[#6])-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C26H42O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-18,22-25,27-29H,3,5-9,12-16H2,1-2,4H3/b21-11+/t17-,18+,22+,23-,24+,25+,26+/m0/s1 | PDB MMDB
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| 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50200182
((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)Show SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r| Show InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1 | PDB MMDB
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| PDB Article PubMed
| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
Bioorg Med Chem 17: 1747-63 (2009)
Article DOI: 10.1016/j.bmc.2008.11.082 BindingDB Entry DOI: 10.7270/Q2MK6CRR |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Retinoic acid receptor alpha
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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TBA
Curated by ChEMBL
| Assay Description Binding affinity towards human Retinoic acid receptor alpha |
Bioorg Med Chem Lett 7: 2313-2318 (1997)
Article DOI: 10.1016/S0960-894X(97)00420-4 BindingDB Entry DOI: 10.7270/Q2Z89CDD |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Homo sapiens (Human)) | BDBM93062
(Vitamin D analog, 11 | Vitamin D analog, 15)Show SMILES C[C@@H](CCCCO)C1CCC2\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1 |r,wU:23.25,25.27,15.17,1.0,wD:21.23,@@:23,(-.69,7.62,;.08,6.29,;1.59,6.61,;2.62,5.46,;4.13,5.78,;5.16,4.64,;6.66,4.96,;-.39,4.82,;.51,3.58,;-.39,2.33,;-1.86,2.81,;-3.19,2.04,;-4.52,2.81,;-4.52,4.35,;-3.19,5.12,;-1.86,4.35,;-1.86,5.89,;-3.19,.5,;-4.52,-.27,;-4.52,-1.81,;-5.86,-2.58,;-5.86,-4.13,;-7.19,-4.9,;-4.52,-4.9,;-4.52,-6.44,;-3.19,-4.13,;-1.86,-4.9,;-3.19,-2.58,)| Show InChI InChI=1S/C25H42O3/c1-17(7-4-5-14-26)21-11-12-22-20(8-6-13-25(21,22)3)10-9-19-15-23(27)18(2)24(28)16-19/h9-10,17-18,21-24,26-28H,4-8,11-16H2,1-3H3/b19-9-,20-10+/t17-,18?,21?,22?,23+,24+,25+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
| Assay Description In vitro study, VDR binding assay were performed as previously described. |
Bioorg Chem 47: 9-16 (2013)
Article DOI: 10.1016/j.bioorg.2013.01.001 BindingDB Entry DOI: 10.7270/Q2FX782T |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417517
(CHEMBL1630757)Show SMILES C[C@H](O)CCC[C@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1 |r,wU:22.24,11.10,16.18,8.7,6.6,wD:26.28,1.1,(14.49,-28.73,;13.13,-29.45,;13.13,-30.99,;11.83,-28.64,;10.47,-29.37,;9.16,-28.56,;7.8,-29.29,;6.46,-28.53,;7.82,-30.83,;8.71,-32.07,;7.8,-33.31,;6.35,-32.82,;5.03,-33.59,;3.68,-32.83,;3.69,-31.28,;5.03,-30.51,;6.36,-31.29,;6.35,-29.75,;5.03,-35.13,;3.69,-35.9,;3.69,-37.44,;5.02,-38.22,;5.02,-39.76,;6.36,-40.53,;3.69,-40.52,;3.69,-42.06,;2.36,-39.76,;1.03,-40.53,;2.36,-38.22,)| Show InChI InChI=1S/C26H44O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-19,22-25,27-29H,5-9,12-16H2,1-4H3/b20-10-,21-11+/t17-,18-,19?,22+,23-,24+,25+,26+/m0/s1 | PDB MMDB
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| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417514
(CHEMBL1630754)Show SMILES [#6]-[#6@@H](-[#8])-[#6]-[#6]-[#6]-[#6@@H](-[#6])-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C26H42O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-18,22-25,27-29H,3,5-9,12-16H2,1-2,4H3/b21-11+/t17-,18-,22-,23+,24-,25-,26-/m1/s1 | PDB MMDB
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University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417513
(CHEMBL1630752)Show SMILES C[C@H](O)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C(=C)[C@H](O)C1=C |r| Show InChI InChI=1S/C27H42O3/c1-17(8-6-9-18(2)28)23-13-14-24-21(10-7-15-27(23,24)5)11-12-22-16-25(29)20(4)26(30)19(22)3/h11-12,17-18,23-26,28-30H,3-4,6-10,13-16H2,1-2,5H3/b21-11+,22-12-/t17-,18+,23-,24+,25-,26-,27-/m1/s1 | PDB MMDB
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University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50388434
(CHEMBL605525)Show SMILES [#6]-[#6@@H](-[#6]-[#6]-[#6]C([#6])([#6])[#8])-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1\[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)22-12-13-23-21(9-7-15-27(22,23)5)11-10-20-16-24(28)19(2)25(29)17-20/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b21-11+/t18-,22+,23-,24+,25+,27+/m0/s1 | PDB MMDB
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University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50200182
((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)Show SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r| Show InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1 | PDB MMDB
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University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50388436
(CHEMBL2059268)Show SMILES [#6]-[#6@@H](-[#6]-[#6]C([#6])([#6])[#8])-[#6@@H](-[#6])-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C28H46O3/c1-18(13-15-27(4,5)31)19(2)23-11-12-24-22(8-7-14-28(23,24)6)10-9-21-16-25(29)20(3)26(30)17-21/h9-10,18-19,23-26,29-31H,3,7-8,11-17H2,1-2,4-6H3/b22-10+/t18-,19+,23+,24-,25+,26+,28+/m0/s1 | PDB MMDB
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University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]-1alpha,25(OH)2D3 from recombinant rat VDR after overnight incubation by scintillation counting |
J Med Chem 55: 4352-66 (2012)
Article DOI: 10.1021/jm300187x BindingDB Entry DOI: 10.7270/Q2PK0H71 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50388434
(CHEMBL605525)Show SMILES [#6]-[#6@@H](-[#6]-[#6]-[#6]C([#6])([#6])[#8])-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1\[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)22-12-13-23-21(9-7-15-27(22,23)5)11-10-20-16-24(28)19(2)25(29)17-20/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b21-11+/t18-,22+,23-,24+,25+,27+/m0/s1 | PDB MMDB
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University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]-1alpha,25(OH)2D3 from recombinant rat VDR after overnight incubation by scintillation counting |
J Med Chem 55: 4352-66 (2012)
Article DOI: 10.1021/jm300187x BindingDB Entry DOI: 10.7270/Q2PK0H71 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50200182
((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)Show SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r| Show InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1 | PDB MMDB
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| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of radiolabeled 1alpha,25-(OH)2D3 from rat recombinant full length VDR |
Bioorg Med Chem 17: 7658-69 (2009)
Article DOI: 10.1016/j.bmc.2009.09.047 BindingDB Entry DOI: 10.7270/Q26T0MQM |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50304583
(1alpha,25-Dihydroxy-2-methylene-18,19,21-trinorvit...)Show SMILES [#6]C([#6])([#8])[#6]-[#6]-[#6]-[#6]-[#6@H]-1-[#6]-[#6]-[#6@@H]2-[#6@@H]-1-[#6]-[#6]-[#6]\[#6]-2=[#6]/[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C25H40O3/c1-17-23(26)15-18(16-24(17)27)10-11-20-8-6-9-21-19(12-13-22(20)21)7-4-5-14-25(2,3)28/h10-11,19,21-24,26-28H,1,4-9,12-16H2,2-3H3/b20-11+/t19-,21+,22-,23+,24+/m0/s1 | PDB MMDB
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| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of radiolabeled 1alpha,25-(OH)2D3 from rat recombinant full length VDR |
Bioorg Med Chem 17: 7658-69 (2009)
Article DOI: 10.1016/j.bmc.2009.09.047 BindingDB Entry DOI: 10.7270/Q26T0MQM |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50200182
((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)Show SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r| Show InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1 | PDB MMDB
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| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]-1alpha,25(OH)2D3 from recombinant rat VDR after overnight incubation by scintillation counting |
J Med Chem 55: 4352-66 (2012)
Article DOI: 10.1021/jm300187x BindingDB Entry DOI: 10.7270/Q2PK0H71 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417516
(CHEMBL1630756)Show SMILES [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1)[C@H](C)CCC[C@H](C)O |r,wU:16.18,10.12,18.20,wD:20.22,4.4,1.0,23.26,28.32,@:18,(-2.52,-29.03,;-4,-29.43,;-3.11,-30.68,;-4.02,-31.92,;-5.47,-31.43,;-5.48,-32.97,;-6.8,-32.2,;-8.14,-31.43,;-8.13,-29.89,;-6.79,-29.12,;-5.46,-29.9,;-5.48,-28.36,;-6.8,-33.74,;-8.13,-34.51,;-8.13,-36.05,;-6.8,-36.83,;-6.8,-38.37,;-5.47,-39.14,;-8.13,-39.13,;-8.13,-40.67,;-9.46,-38.37,;-10.79,-39.14,;-9.46,-36.83,;-4.02,-27.89,;-5.36,-27.14,;-2.66,-27.16,;-1.35,-27.98,;0,-27.25,;1.31,-28.06,;2.67,-27.33,;1.31,-29.6,)| Show InChI InChI=1S/C26H44O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-19,22-25,27-29H,5-9,12-16H2,1-4H3/b20-10-,21-11+/t17-,18+,19?,22-,23+,24-,25-,26-/m1/s1 | PDB MMDB
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Homo sapiens (Human)) | BDBM93067
(Vitamin D analog, 13 | Vitamin D analog, 17)Show SMILES CCCC[C@H](C)C1CCC2\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1 |r,wU:22.24,24.26,14.16,4.4,wD:20.22,@@:22,(5.16,4.64,;4.13,5.78,;2.62,5.46,;1.59,6.61,;.08,6.29,;-.69,7.62,;-.39,4.82,;.51,3.58,;-.39,2.33,;-1.86,2.81,;-3.19,2.04,;-4.52,2.81,;-4.52,4.35,;-3.19,5.12,;-1.86,4.35,;-1.86,5.89,;-3.19,.5,;-4.52,-.27,;-4.52,-1.81,;-5.86,-2.58,;-5.86,-4.13,;-7.19,-4.9,;-4.52,-4.9,;-4.52,-6.44,;-3.19,-4.13,;-1.86,-4.9,;-3.19,-2.58,)| Show InChI InChI=1S/C25H42O2/c1-5-6-8-17(2)21-12-13-22-20(9-7-14-25(21,22)4)11-10-19-15-23(26)18(3)24(27)16-19/h10-11,17-18,21-24,26-27H,5-9,12-16H2,1-4H3/b19-10-,20-11+/t17-,18?,21?,22?,23+,24+,25+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
| Assay Description In vitro study, VDR binding assay were performed as previously described. |
Bioorg Chem 47: 9-16 (2013)
Article DOI: 10.1016/j.bioorg.2013.01.001 BindingDB Entry DOI: 10.7270/Q2FX782T |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417514
(CHEMBL1630754)Show SMILES [#6]-[#6@@H](-[#8])-[#6]-[#6]-[#6]-[#6@@H](-[#6])-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C26H42O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-18,22-25,27-29H,3,5-9,12-16H2,1-2,4H3/b21-11+/t17-,18-,22-,23+,24-,25-,26-/m1/s1 | PDB MMDB
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UniProtKB/SwissProt
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| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription... |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50304584
(1alpha,25-Dihydroxy-2-methylene-19,21-dinorvitamin...)Show SMILES [#6]C([#6])([#8])[#6]-[#6]-[#6]-[#6]-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1\[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C26H42O3/c1-18-23(27)16-19(17-24(18)28)10-11-20-8-7-15-26(4)21(12-13-22(20)26)9-5-6-14-25(2,3)29/h10-11,21-24,27-29H,1,5-9,12-17H2,2-4H3/b20-11+/t21-,22-,23+,24+,26+/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
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| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of radiolabeled 1alpha,25-(OH)2D3 from rat recombinant full length VDR |
Bioorg Med Chem 17: 7658-69 (2009)
Article DOI: 10.1016/j.bmc.2009.09.047 BindingDB Entry DOI: 10.7270/Q26T0MQM |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Homo sapiens (Human)) | BDBM93061
(Vitamin D analog, 6)Show SMILES [#6]-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#8])-[#6]1-[#6]-[#6]-[#6]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1\[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C25H40O3/c1-17(7-4-5-14-26)21-11-12-22-20(8-6-13-25(21,22)3)10-9-19-15-23(27)18(2)24(28)16-19/h9-10,17,21-24,26-28H,2,4-8,11-16H2,1,3H3/b20-10+/t17-,21?,22?,23-,24-,25-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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Similars
| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
| Assay Description In vitro study, VDR binding assay were performed as previously described. |
Bioorg Chem 47: 9-16 (2013)
Article DOI: 10.1016/j.bioorg.2013.01.001 BindingDB Entry DOI: 10.7270/Q2FX782T |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50388435
(CHEMBL2059267)Show SMILES [#6]-[#6@H](-[#6]-[#6]C([#6])([#6])[#8])-[#6@@H](-[#6])-[#6@H]1-[#6]-[#6]-[#6@H]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C28H46O3/c1-18(13-15-27(4,5)31)19(2)23-11-12-24-22(8-7-14-28(23,24)6)10-9-21-16-25(29)20(3)26(30)17-21/h9-10,18-19,23-26,29-31H,3,7-8,11-17H2,1-2,4-6H3/b22-10+/t18-,19-,23-,24+,25-,26-,28-/m1/s1 | PDB MMDB
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UniProtKB/SwissProt
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| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]-1alpha,25(OH)2D3 from recombinant rat VDR after overnight incubation by scintillation counting |
J Med Chem 55: 4352-66 (2012)
Article DOI: 10.1021/jm300187x BindingDB Entry DOI: 10.7270/Q2PK0H71 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50200182
((1S,3R,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-...)Show SMILES C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C |r| Show InChI InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1 | PDB MMDB
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| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription... |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417518
(CHEMBL1630758)Show SMILES [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1)[C@H](C)CCC[C@@H](C)O |r,wU:16.18,10.12,18.20,28.32,wD:20.22,4.4,1.0,23.26,@:18,(22,-29.84,;20.52,-30.25,;21.41,-31.5,;20.5,-32.73,;19.05,-32.25,;19.04,-33.79,;17.73,-33.02,;16.38,-32.25,;16.39,-30.71,;17.73,-29.94,;19.06,-30.72,;19.05,-29.17,;17.73,-34.56,;16.39,-35.33,;16.39,-36.87,;17.72,-37.64,;17.72,-39.18,;19.06,-39.96,;16.39,-39.95,;16.39,-41.49,;15.07,-39.18,;13.73,-39.96,;15.07,-37.64,;20.5,-28.71,;19.16,-27.96,;21.86,-27.98,;23.17,-28.79,;24.53,-28.07,;25.84,-28.88,;27.19,-28.15,;25.83,-30.41,)| Show InChI InChI=1S/C26H44O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-19,22-25,27-29H,5-9,12-16H2,1-4H3/b20-10-,21-11+/t17-,18-,19?,22-,23+,24-,25-,26-/m1/s1 | PDB MMDB
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UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Homo sapiens (Human)) | BDBM93064
(Vitamin D analog, 9)Show SMILES [#6]-[#6]-[#6]-[#6]-[#6@H](-[#6])-[#6]1-[#6]-[#6]-[#6]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1\[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C25H40O2/c1-5-6-8-17(2)21-12-13-22-20(9-7-14-25(21,22)4)11-10-19-15-23(26)18(3)24(27)16-19/h10-11,17,21-24,26-27H,3,5-9,12-16H2,1-2,4H3/b20-11+/t17-,21?,22?,23+,24+,25+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
| Assay Description In vitro study, VDR binding assay were performed as previously described. |
Bioorg Chem 47: 9-16 (2013)
Article DOI: 10.1016/j.bioorg.2013.01.001 BindingDB Entry DOI: 10.7270/Q2FX782T |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Homo sapiens (Human)) | BDBM93063
(Vitamin D analog, 8)Show SMILES [#6]-[#6]-[#6]-[#6]-[#6@@H](-[#6])-[#6]1-[#6]-[#6]-[#6]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1\[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C25H40O2/c1-5-6-8-17(2)21-12-13-22-20(9-7-14-25(21,22)4)11-10-19-15-23(26)18(3)24(27)16-19/h10-11,17,21-24,26-27H,3,5-9,12-16H2,1-2,4H3/b20-11+/t17-,21?,22?,23-,24-,25-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
| Assay Description In vitro study, VDR binding assay were performed as previously described. |
Bioorg Chem 47: 9-16 (2013)
Article DOI: 10.1016/j.bioorg.2013.01.001 BindingDB Entry DOI: 10.7270/Q2FX782T |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Homo sapiens (Human)) | BDBM93072
(Vitamin D analog, 7)Show SMILES [#6]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#8])-[#6]1-[#6]-[#6]-[#6]2\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1\[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1 |r| Show InChI InChI=1S/C25H40O3/c1-17(7-4-5-14-26)21-11-12-22-20(8-6-13-25(21,22)3)10-9-19-15-23(27)18(2)24(28)16-19/h9-10,17,21-24,26-28H,2,4-8,11-16H2,1,3H3/b20-10+/t17-,21?,22?,23+,24+,25+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
| Assay Description In vitro study, VDR binding assay were performed as previously described. |
Bioorg Chem 47: 9-16 (2013)
Article DOI: 10.1016/j.bioorg.2013.01.001 BindingDB Entry DOI: 10.7270/Q2FX782T |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
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| MMDB Article
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity towards cRARbeta2 receptor by displacing 1.1 nM 3[H]-9-cis-RA |
Bioorg Med Chem Lett 7: 2313-2318 (1997)
Article DOI: 10.1016/S0960-894X(97)00420-4 BindingDB Entry DOI: 10.7270/Q2Z89CDD |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417513
(CHEMBL1630752)Show SMILES C[C@H](O)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C(=C)[C@H](O)C1=C |r| Show InChI InChI=1S/C27H42O3/c1-17(8-6-9-18(2)28)23-13-14-24-21(10-7-15-27(23,24)5)11-12-22-16-25(29)20(4)26(30)19(22)3/h11-12,17-18,23-26,28-30H,3-4,6-10,13-16H2,1-2,5H3/b21-11+,22-12-/t17-,18+,23-,24+,25-,26-,27-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription... |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417518
(CHEMBL1630758)Show SMILES [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1)[C@H](C)CCC[C@@H](C)O |r,wU:16.18,10.12,18.20,28.32,wD:20.22,4.4,1.0,23.26,@:18,(22,-29.84,;20.52,-30.25,;21.41,-31.5,;20.5,-32.73,;19.05,-32.25,;19.04,-33.79,;17.73,-33.02,;16.38,-32.25,;16.39,-30.71,;17.73,-29.94,;19.06,-30.72,;19.05,-29.17,;17.73,-34.56,;16.39,-35.33,;16.39,-36.87,;17.72,-37.64,;17.72,-39.18,;19.06,-39.96,;16.39,-39.95,;16.39,-41.49,;15.07,-39.18,;13.73,-39.96,;15.07,-37.64,;20.5,-28.71,;19.16,-27.96,;21.86,-27.98,;23.17,-28.79,;24.53,-28.07,;25.84,-28.88,;27.19,-28.15,;25.83,-30.41,)| Show InChI InChI=1S/C26H44O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-19,22-25,27-29H,5-9,12-16H2,1-4H3/b20-10-,21-11+/t17-,18-,19?,22-,23+,24-,25-,26-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription... |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417519
(CHEMBL1630759)Show SMILES C[C@@H](O)CCC[C@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1 |r,wU:22.24,11.10,16.18,8.7,6.6,1.1,wD:26.28,(1.96,-41.79,;.6,-42.52,;.6,-44.06,;-.7,-41.71,;-2.06,-42.44,;-3.37,-41.62,;-4.73,-42.35,;-6.07,-41.6,;-4.71,-43.89,;-3.82,-45.14,;-4.73,-46.37,;-6.18,-45.89,;-7.5,-46.66,;-8.85,-45.89,;-8.84,-44.35,;-7.5,-43.58,;-6.17,-44.36,;-6.18,-42.82,;-7.5,-48.2,;-8.84,-48.97,;-8.84,-50.51,;-7.51,-51.29,;-7.51,-52.83,;-6.17,-53.6,;-8.84,-53.59,;-8.84,-55.13,;-10.17,-52.83,;-11.51,-53.6,;-10.17,-51.29,)| Show InChI InChI=1S/C26H44O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-19,22-25,27-29H,5-9,12-16H2,1-4H3/b20-10-,21-11+/t17-,18+,19?,22+,23-,24+,25+,26+/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
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| MMDB Article
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [3H]-RA to binding Retinoic acid receptor RAR gamma |
Bioorg Med Chem Lett 4: 2117-2122 (1994)
Article DOI: 10.1016/S0960-894X(01)80113-X BindingDB Entry DOI: 10.7270/Q2V40V4W |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417517
(CHEMBL1630757)Show SMILES C[C@H](O)CCC[C@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1 |r,wU:22.24,11.10,16.18,8.7,6.6,wD:26.28,1.1,(14.49,-28.73,;13.13,-29.45,;13.13,-30.99,;11.83,-28.64,;10.47,-29.37,;9.16,-28.56,;7.8,-29.29,;6.46,-28.53,;7.82,-30.83,;8.71,-32.07,;7.8,-33.31,;6.35,-32.82,;5.03,-33.59,;3.68,-32.83,;3.69,-31.28,;5.03,-30.51,;6.36,-31.29,;6.35,-29.75,;5.03,-35.13,;3.69,-35.9,;3.69,-37.44,;5.02,-38.22,;5.02,-39.76,;6.36,-40.53,;3.69,-40.52,;3.69,-42.06,;2.36,-39.76,;1.03,-40.53,;2.36,-38.22,)| Show InChI InChI=1S/C26H44O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-19,22-25,27-29H,5-9,12-16H2,1-4H3/b20-10-,21-11+/t17-,18-,19?,22+,23-,24+,25+,26+/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Displacement of [3H]1alpha,25-(OH)2D3 from rat recombinant full length VDR |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50032219
((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ | PDB MMDB
Reactome pathway KEGG
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| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity towards cRARbeta2 receptor by displacing 1.1 nM 3[H]-9-cis-RA |
Bioorg Med Chem Lett 7: 2313-2318 (1997)
Article DOI: 10.1016/S0960-894X(97)00420-4 BindingDB Entry DOI: 10.7270/Q2Z89CDD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB MMDB
Reactome pathway KEGG
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| MMDB Article
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity towards cRARbeta2 receptor by displacing 0.82 nM 3[H]-all-trans-RA |
Bioorg Med Chem Lett 7: 2313-2318 (1997)
Article DOI: 10.1016/S0960-894X(97)00420-4 BindingDB Entry DOI: 10.7270/Q2Z89CDD |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM31892
(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+ | PDB MMDB
Reactome pathway KEGG
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| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity towards cRARbeta2 receptor by displacing 1.1 nM 3[H]-9-cis-RA |
Bioorg Med Chem Lett 7: 2313-2318 (1997)
Article DOI: 10.1016/S0960-894X(97)00420-4 BindingDB Entry DOI: 10.7270/Q2Z89CDD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM50032219
((E)-4-(2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydrona...)Show SMILES C\C(=C/c1ccc(cc1)C(O)=O)c1ccc2c(c1)C(C)(C)CCC2(C)C Show InChI InChI=1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+ | PDB MMDB
Reactome pathway KEGG
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| PDB Article
| 0.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity towards cRARbeta2 receptor by displacing 0.82 nM 3[H]-all-trans-RA |
Bioorg Med Chem Lett 7: 2313-2318 (1997)
Article DOI: 10.1016/S0960-894X(97)00420-4 BindingDB Entry DOI: 10.7270/Q2Z89CDD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Retinoic acid receptor gamma
(Homo sapiens (Human)) | BDBM31883
(9-cis-retinoic acid (9cRA) | ALL-TRANS-RETINOIC AC...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE KEGG MMDB PC cid PC sid UniChem
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| MMDB Article
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity towards human Retinoic acid receptor gamma |
Bioorg Med Chem Lett 7: 2313-2318 (1997)
Article DOI: 10.1016/S0960-894X(97)00420-4 BindingDB Entry DOI: 10.7270/Q2Z89CDD |
More data for this Ligand-Target Pair | |
Vitamin D3 receptor
(Rattus norvegicus) | BDBM50417516
(CHEMBL1630756)Show SMILES [H][C@@]1(CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1C[C@@H](O)C(C)[C@H](O)C1)[C@H](C)CCC[C@H](C)O |r,wU:16.18,10.12,18.20,wD:20.22,4.4,1.0,23.26,28.32,@:18,(-2.52,-29.03,;-4,-29.43,;-3.11,-30.68,;-4.02,-31.92,;-5.47,-31.43,;-5.48,-32.97,;-6.8,-32.2,;-8.14,-31.43,;-8.13,-29.89,;-6.79,-29.12,;-5.46,-29.9,;-5.48,-28.36,;-6.8,-33.74,;-8.13,-34.51,;-8.13,-36.05,;-6.8,-36.83,;-6.8,-38.37,;-5.47,-39.14,;-8.13,-39.13,;-8.13,-40.67,;-9.46,-38.37,;-10.79,-39.14,;-9.46,-36.83,;-4.02,-27.89,;-5.36,-27.14,;-2.66,-27.16,;-1.35,-27.98,;0,-27.25,;1.31,-28.06,;2.67,-27.33,;1.31,-29.6,)| Show InChI InChI=1S/C26H44O3/c1-17(7-5-8-18(2)27)22-12-13-23-21(9-6-14-26(22,23)4)11-10-20-15-24(28)19(3)25(29)16-20/h10-11,17-19,22-25,27-29H,5-9,12-16H2,1-4H3/b20-10-,21-11+/t17-,18+,19?,22-,23+,24-,25-,26-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Wisconsin-Madison
Curated by ChEMBL
| Assay Description Activity at rat recombinant full length VDR expressed in rat ROS 17/2.8 cells transfected with 24-hydroxylase gene promoter assessed as transcription... |
J Med Chem 53: 8642-9 (2010)
Article DOI: 10.1021/jm1010447 BindingDB Entry DOI: 10.7270/Q23B61D2 |
More data for this Ligand-Target Pair | |
Retinoic acid receptor beta
(Homo sapiens (Human)) | BDBM31892
(9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin...)Show SMILES C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O |c:4| Show InChI InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
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| DrugBank PDB Article
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity towards cRARbeta2 receptor by displacing 1.1 nM 3[H]-9-cis-RA |
Bioorg Med Chem Lett 7: 2313-2318 (1997)
Article DOI: 10.1016/S0960-894X(97)00420-4 BindingDB Entry DOI: 10.7270/Q2Z89CDD |
More data for this Ligand-Target Pair | 3D Structure (crystal) |