Compile Data Set for Download or QSAR

Found 331 hits with Last Name = 'connors' and Initial = 'pj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149255 (3-((R)-2-Cyclopentyl-2-dimethylamino-ethyl)-1-(2,6...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](C2CCCC2)N(C)C)c1=O |wU:26.34,(6.63,1.74,;5.3,.97,;5.3,-.57,;6.65,-1.34,;6.63,-2.89,;5.3,-3.65,;3.97,-2.88,;3.97,-1.34,;2.64,-.57,;2.64,-3.64,;2.64,-5.16,;3.97,-5.93,;1.29,-5.96,;1.29,-7.5,;2.62,-8.26,;2.62,-9.81,;1.29,-10.58,;3.95,-10.58,;5.3,-9.81,;5.3,-8.26,;3.95,-7.47,;5.05,-6.39,;-.04,-5.18,;-.05,-6.68,;-.04,-3.62,;-1.37,-2.85,;-2.7,-3.62,;-2.7,-5.16,;-3.96,-6.07,;-3.48,-7.54,;-1.94,-7.54,;-1.46,-6.07,;-4.03,-2.85,;-5.36,-3.62,;-4.03,-1.31,;1.31,-2.85,;1.31,-1.31,)| Show InChI InChI=1S/C28H32F3N3O3/c1-17-25(19-11-7-14-24(37-4)26(19)31)27(35)34(16-23(32(2)3)18-9-5-6-10-18)28(36)33(17)15-20-21(29)12-8-13-22(20)30/h7-8,11-14,18,23H,5-6,9-10,15-16H2,1-4H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50423641 (A-198401 | CHEMBL303274) Show SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2[C@@H](C)COC2=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)CC2CC2)[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C)OC Show InChI InChI=1S/C47H69Cl2N3O13/c1-12-35-47(9)39(51(43(56)65-47)18-17-30-15-16-32(48)33(49)20-30)27(5)36(53)24(2)21-46(8,59-11)40(64-42-37(54)34(19-26(4)61-42)50(10)22-31-13-14-31)28(6)38(29(7)41(55)62-35)63-45(58)52-25(3)23-60-44(52)57/h15-16,20,24-29,31,34-35,37-40,42,54H,12-14,17-19,21-23H2,1-11H3/t24-,25+,26-,27+,28+,29-,34+,35-,37-,38+,39-,40-,42+,46+,47-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.631	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Ability of compound to inhibit [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt]GnRH agonist binding to the rat Gonadotropin-releasing hormone receptor was evaluate...				Bioorg Med Chem Lett 12: 2179-83 (2002) BindingDB Entry DOI: 10.7270/Q28S4P8D
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109235 (7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[...) Show SMILES CCCC(=O)Nc1ccc(cc1)-c1cc2n(Cc3ccccc3F)cc(C(=O)NCCCc3ccccc3)c(=O)n2c1CN(C)CCc1ccccn1 Show InChI InChI=1S/C43H45FN6O3/c1-3-12-40(51)47-35-21-19-32(20-22-35)36-27-41-49(28-33-16-7-8-18-38(33)44)29-37(42(52)46-25-11-15-31-13-5-4-6-14-31)43(53)50(41)39(36)30-48(2)26-23-34-17-9-10-24-45-34/h4-10,13-14,16-22,24,27,29H,3,11-12,15,23,25-26,28,30H2,1-2H3,(H,46,52)(H,47,51)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...				Bioorg Med Chem Lett 12: 403-6 (2002) BindingDB Entry DOI: 10.7270/Q2542MXV
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50140110 ((R)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyph...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](C)NCc2ccccn2)c1=O |r,wU:26.28,(4.78,5.66,;3.45,4.89,;3.45,3.35,;4.79,2.58,;4.79,1.04,;3.45,.27,;2.12,1.05,;2.12,2.58,;.79,3.35,;.79,.29,;.79,-1.25,;2.12,-2.02,;-.54,-2.01,;-.54,-3.55,;.8,-4.32,;2.12,-3.56,;.78,-2.78,;3.45,-4.32,;3.46,-5.87,;2.12,-6.64,;.79,-5.87,;-.55,-6.63,;-1.87,-1.25,;-3.2,-2.02,;-1.87,.29,;-3.2,1.05,;-4.53,.28,;-4.53,-1.26,;-5.87,1.05,;-7.2,.27,;-8.54,1.04,;-9.86,.26,;-11.19,1.02,;-11.21,2.57,;-9.87,3.34,;-8.53,2.58,;-.54,1.07,;-.54,2.61,)| Show InChI InChI=1S/C28H27F3N4O3/c1-17(33-14-19-8-4-5-13-32-19)15-35-27(36)25(20-9-6-12-24(38-3)26(20)31)18(2)34(28(35)37)16-21-22(29)10-7-11-23(21)30/h4-13,17,33H,14-16H2,1-3H3/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...				J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50127191 (2-(8-(2-Fluoro-benzyl)-6-(3-methoxy-phenyl)-7-meth...) Show SMILES COC(=O)C(C)(C)c1nc2n(Cc3ccccc3F)c(C)c(-c3cccc(OC)c3)c(=O)n2c1CN(C)CCc1ccccn1 Show InChI InChI=1S/C35H38FN5O4/c1-23-30(24-13-11-15-27(20-24)44-5)32(42)41-29(22-39(4)19-17-26-14-9-10-18-37-26)31(35(2,3)33(43)45-6)38-34(41)40(23)21-25-12-7-8-16-28(25)36/h7-16,18,20H,17,19,21-22H2,1-6H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity against human gonadotropin-releasing hormone receptor				J Med Chem 46: 1769-72 (2003) Article DOI: 10.1021/jm0205402 BindingDB Entry DOI: 10.7270/Q2474983
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109234 (7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[...) Show SMILES CCCC(=O)Nc1ccc(cc1)-c1cc2n(Cc3ccccc3F)cc(C(=O)OCC)c(=O)n2c1CN(C)CCc1ccccn1 Show InChI InChI=1S/C36H38FN5O4/c1-4-10-33(43)39-28-16-14-25(15-17-28)29-21-34-41(22-26-11-6-7-13-31(26)37)23-30(36(45)46-5-2)35(44)42(34)32(29)24-40(3)20-18-27-12-8-9-19-38-27/h6-9,11-17,19,21,23H,4-5,10,18,20,22,24H2,1-3H3,(H,39,43)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...				Bioorg Med Chem Lett 12: 403-6 (2002) BindingDB Entry DOI: 10.7270/Q2542MXV
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149263 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) Show SMILES CN[C@H](CC(C)C)Cn1c(=O)c(c(C)n(Cc2c(F)cccc2F)c1=O)-c1cccc(OC)c1F |wU:2.1,(3.53,-4.51,;4.86,-3.74,;6.19,-4.51,;6.19,-6.05,;4.86,-6.82,;3.53,-6.05,;4.85,-8.36,;7.54,-3.76,;8.87,-4.53,;10.2,-3.76,;10.2,-2.22,;11.53,-4.53,;11.53,-6.07,;12.86,-6.84,;10.2,-6.84,;10.2,-8.38,;11.53,-9.15,;12.86,-8.38,;13.94,-7.29,;14.19,-9.15,;14.19,-10.69,;12.86,-11.46,;11.53,-10.69,;10.18,-11.46,;8.87,-6.07,;7.52,-6.84,;12.86,-3.76,;14.19,-4.55,;15.54,-3.79,;15.55,-2.24,;14.19,-1.47,;14.19,.07,;15.54,.84,;12.86,-2.24,;11.53,-1.45,)| Show InChI InChI=1S/C26H30F3N3O3/c1-15(2)12-17(30-4)13-32-25(33)23(18-8-6-11-22(35-5)24(18)29)16(3)31(26(32)34)14-19-20(27)9-7-10-21(19)28/h6-11,15,17,30H,12-14H2,1-5H3/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50152714 ((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...) Show SMILES Cc1c(-c2ccc(Cl)s2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F |r| Show InChI InChI=1S/C24H20ClF2N3O2S/c1-14-22(20-10-11-21(25)33-20)23(31)30(13-19(28)15-6-3-2-4-7-15)24(32)29(14)12-16-17(26)8-5-9-18(16)27/h2-11,19H,12-13,28H2,1H3/t19-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards cloned human Gonadotropin-releasing hormone receptor expressed in RBL cells was determined by using [125I]-GnRH as radioliga...				Bioorg Med Chem Lett 14: 4967-73 (2004) Article DOI: 10.1016/j.bmcl.2004.07.022 BindingDB Entry DOI: 10.7270/Q2FF3RT4
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50423641 (A-198401 | CHEMBL303274) Show SMILES CC[C@H]1OC(=O)[C@H](C)[C@@H](OC(=O)N2[C@@H](C)COC2=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)CC2CC2)[C@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCc3ccc(Cl)c(Cl)c3)C(=O)O[C@]12C)OC Show InChI InChI=1S/C47H69Cl2N3O13/c1-12-35-47(9)39(51(43(56)65-47)18-17-30-15-16-32(48)33(49)20-30)27(5)36(53)24(2)21-46(8,59-11)40(64-42-37(54)34(19-26(4)61-42)50(10)22-31-13-14-31)28(6)38(29(7)41(55)62-35)63-45(58)52-25(3)23-60-44(52)57/h15-16,20,24-29,31,34-35,37-40,42,54H,12-14,17-19,21-23H2,1-11H3/t24-,25+,26-,27+,28+,29-,34+,35-,37-,38+,39-,40-,42+,46+,47-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Ability of compound to inhibit [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt]GnRH agonist binding to the cloned human Gonadotropin-releasing hormone receptor was...				Bioorg Med Chem Lett 12: 2179-83 (2002) BindingDB Entry DOI: 10.7270/Q28S4P8D
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109255 (7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-[(...) Show SMILES CCCC(=O)Nc1ccc(cc1)-c1cc2n(Cc3ccccc3F)cc(C(=O)OC(CC)CC)c(=O)n2c1CN(C)CCc1ccccc1 Show InChI InChI=1S/C40H45FN4O4/c1-5-13-37(46)42-31-20-18-29(19-21-31)33-24-38-44(25-30-16-11-12-17-35(30)41)26-34(40(48)49-32(6-2)7-3)39(47)45(38)36(33)27-43(4)23-22-28-14-9-8-10-15-28/h8-12,14-21,24,26,32H,5-7,13,22-23,25,27H2,1-4H3,(H,42,46)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...				Bioorg Med Chem Lett 12: 403-6 (2002) BindingDB Entry DOI: 10.7270/Q2542MXV
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149259 (3-((S)-2-Cyclopentyl-2-dimethylamino-ethyl)-1-(2,6...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C2CCCC2)N(C)C)c1=O |wD:26.34,(26.87,2.44,;25.54,1.67,;25.54,.13,;26.88,-.64,;26.87,-2.19,;25.54,-2.95,;24.21,-2.18,;24.21,-.64,;22.88,.13,;22.87,-2.94,;22.87,-4.47,;24.2,-5.24,;21.52,-5.26,;21.52,-6.8,;22.85,-7.56,;22.85,-9.11,;21.52,-9.88,;24.18,-9.88,;25.53,-9.11,;25.53,-7.56,;24.18,-6.79,;25.28,-5.69,;20.19,-4.48,;20.17,-5.94,;20.19,-2.92,;18.86,-2.15,;17.53,-2.92,;17.53,-4.47,;16.29,-5.37,;16.76,-6.84,;18.3,-6.84,;18.77,-5.38,;16.2,-2.15,;14.87,-2.92,;16.2,-.61,;21.54,-2.15,;21.55,-.61,)| Show InChI InChI=1S/C28H32F3N3O3/c1-17-25(19-11-7-14-24(37-4)26(19)31)27(35)34(16-23(32(2)3)18-9-5-6-10-18)28(36)33(17)15-20-21(29)12-8-13-22(20)30/h7-8,11-14,18,23H,5-6,9-10,15-16H2,1-4H3/t23-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109245 (7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[...) Show SMILES CCCC(=O)Nc1ccc(cc1)-c1cc2n(Cc3ccccc3F)cc(C(=O)OC(CC)CC)c(=O)n2c1CN(C)CCc1ccccn1 Show InChI InChI=1S/C39H44FN5O4/c1-5-12-36(46)42-30-18-16-27(17-19-30)32-23-37-44(24-28-13-8-9-15-34(28)40)25-33(39(48)49-31(6-2)7-3)38(47)45(37)35(32)26-43(4)22-20-29-14-10-11-21-41-29/h8-11,13-19,21,23,25,31H,5-7,12,20,22,24,26H2,1-4H3,(H,42,46)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Ability to inhibit [I125-Tyr5,DLeu6,NMeLeu7,Pro9-NEt]GnRH agonist binding to the cloned human Gonadotropin-releasing hormone receptor was evaluated				Bioorg Med Chem Lett 12: 2179-83 (2002) BindingDB Entry DOI: 10.7270/Q28S4P8D
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109245 (7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[...) Show SMILES CCCC(=O)Nc1ccc(cc1)-c1cc2n(Cc3ccccc3F)cc(C(=O)OC(CC)CC)c(=O)n2c1CN(C)CCc1ccccn1 Show InChI InChI=1S/C39H44FN5O4/c1-5-12-36(46)42-30-18-16-27(17-19-30)32-23-37-44(24-28-13-8-9-15-34(28)40)25-33(39(48)49-31(6-2)7-3)38(47)45(37)35(32)26-43(4)22-20-29-14-10-11-21-41-29/h8-11,13-19,21,23,25,31H,5-7,12,20,22,24,26H2,1-4H3,(H,42,46)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...				Bioorg Med Chem Lett 12: 403-6 (2002) BindingDB Entry DOI: 10.7270/Q2542MXV
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109252 (7-(4-Acetylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[m...) Show SMILES CCC(CC)OC(=O)c1cn(Cc2ccccc2F)c2cc(c(CN(C)CCc3ccccn3)n2c1=O)-c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C37H40FN5O4/c1-5-30(6-2)47-37(46)32-23-42(22-27-11-7-8-13-33(27)38)35-21-31(26-14-16-29(17-15-26)40-25(3)44)34(43(35)36(32)45)24-41(4)20-18-28-12-9-10-19-39-28/h7-17,19,21,23,30H,5-6,18,20,22,24H2,1-4H3,(H,40,44)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...				Bioorg Med Chem Lett 12: 403-6 (2002) BindingDB Entry DOI: 10.7270/Q2542MXV
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50152708 (3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...) Show SMILES Cc1ccc(s1)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)c2ccccc2)c1=O Show InChI InChI=1S/C25H23F2N3O2S/c1-15-11-12-22(33-15)23-16(2)29(13-18-19(26)9-6-10-20(18)27)25(32)30(24(23)31)14-21(28)17-7-4-3-5-8-17/h3-12,21H,13-14,28H2,1-2H3/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards cloned human Gonadotropin-releasing hormone receptor expressed in RBL cells was determined by using [125I]-GnRH as radioliga...				Bioorg Med Chem Lett 14: 4967-73 (2004) Article DOI: 10.1016/j.bmcl.2004.07.022 BindingDB Entry DOI: 10.7270/Q2FF3RT4
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50140096 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(CCN(C)CCc2ccccn2)c1=O |(7.94,4.31,;6.59,3.52,;6.62,1.96,;7.97,1.2,;7.98,-.34,;6.64,-1.12,;5.31,-.36,;5.29,1.18,;4.18,2.29,;3.99,-1.15,;3.99,-2.69,;5.34,-3.44,;2.66,-3.46,;2.68,-5,;1.33,-5.78,;1.35,-7.31,;2.42,-8.39,;.03,-8.09,;-1.32,-7.32,;-1.33,-5.78,;.01,-5.01,;-1.11,-3.89,;1.33,-2.7,;,-3.47,;1.33,-1.16,;,-.39,;-1.34,-1.17,;-2.67,-.4,;-2.68,1.14,;-4,-1.18,;-5.35,-.41,;-6.67,-1.19,;-8.01,-.41,;-9.33,-1.19,;-9.33,-2.73,;-8.01,-3.51,;-6.67,-2.73,;2.65,-.38,;2.64,1.16,)| Show InChI InChI=1S/C29H29F3N4O3/c1-19-26(21-9-6-12-25(39-3)27(21)32)28(37)35(17-16-34(2)15-13-20-8-4-5-14-33-20)29(38)36(19)18-22-23(30)10-7-11-24(22)31/h4-12,14H,13,15-18H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...				J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109238 (7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[...) Show SMILES CCCCCCNC(=O)c1cn(Cc2ccccc2F)c2cc(c(CN(C)CCc3ccccn3)n2c1=O)-c1ccc(NC(=O)CCC)cc1 Show InChI InChI=1S/C40H47FN6O3/c1-4-6-7-11-23-43-39(49)34-27-46(26-30-14-8-9-16-35(30)41)38-25-33(29-17-19-32(20-18-29)44-37(48)13-5-2)36(47(38)40(34)50)28-45(3)24-21-31-15-10-12-22-42-31/h8-10,12,14-20,22,25,27H,4-7,11,13,21,23-24,26,28H2,1-3H3,(H,43,49)(H,44,48)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...				Bioorg Med Chem Lett 12: 403-6 (2002) BindingDB Entry DOI: 10.7270/Q2542MXV
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109253 (6-[(Benzyl-methyl-amino)-methyl]-7-(4-butyrylamino...) Show SMILES CCCC(=O)Nc1ccc(cc1)-c1cc2n(Cc3ccccc3F)cc(C(=O)OC(CC)CC)c(=O)n2c1CN(C)Cc1ccccc1 Show InChI InChI=1S/C39H43FN4O4/c1-5-13-36(45)41-30-20-18-28(19-21-30)32-22-37-43(24-29-16-11-12-17-34(29)40)25-33(39(47)48-31(6-2)7-3)38(46)44(37)35(32)26-42(4)23-27-14-9-8-10-15-27/h8-12,14-22,25,31H,5-7,13,23-24,26H2,1-4H3,(H,41,45)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...				Bioorg Med Chem Lett 12: 403-6 (2002) BindingDB Entry DOI: 10.7270/Q2542MXV
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50140111 ((R)-1-(2,6-difluorobenzyl)-3-(1-(2-methoxybenzylam...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n([C@H](C)CNCc2ccccc2OC)c1=O |r,wU:25.27,(21.58,4.68,;20.25,3.91,;20.25,2.37,;21.59,1.59,;21.59,.05,;20.25,-.71,;18.92,.06,;18.92,1.6,;17.59,2.37,;17.59,-.7,;17.59,-2.24,;18.92,-3.01,;16.26,-3,;16.26,-4.54,;17.6,-5.31,;18.92,-4.54,;17.58,-3.77,;20.25,-5.31,;20.26,-6.85,;18.92,-7.62,;17.59,-6.85,;16.25,-7.62,;14.93,-2.24,;13.6,-3.01,;14.93,-.7,;13.6,.07,;13.59,1.61,;12.27,-.71,;10.93,.06,;10.93,1.6,;9.59,2.36,;8.27,1.59,;6.93,2.35,;6.92,3.9,;8.26,4.67,;9.59,3.91,;10.92,4.68,;12.26,3.91,;16.26,.08,;16.26,1.62,)| Show InChI InChI=1S/C30H30F3N3O4/c1-18(15-34-16-20-9-5-6-13-25(20)39-3)36-29(37)27(21-10-7-14-26(40-4)28(21)33)19(2)35(30(36)38)17-22-23(31)11-8-12-24(22)32/h5-14,18,34H,15-17H2,1-4H3/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...				J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50140098 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)NCc2sccc2C)c1=O |wU:26.28,(9.6,-.48,;8.26,-1.28,;8.28,-2.84,;9.61,-3.59,;9.63,-5.13,;8.31,-5.91,;6.98,-5.14,;6.96,-3.6,;5.84,-2.49,;5.65,-5.92,;5.66,-7.46,;7,-8.23,;4.34,-8.24,;4.34,-9.77,;3,-10.56,;1.68,-9.77,;.58,-8.68,;.34,-10.56,;.34,-12.09,;1.69,-12.85,;3.01,-12.07,;4.1,-13.16,;2.99,-7.48,;1.66,-8.24,;2.99,-5.94,;1.66,-5.16,;1.66,-3.6,;3.01,-2.82,;.31,-2.84,;.31,-1.28,;-1.17,-.76,;-1.62,.73,;-3.18,.77,;-3.69,-.71,;-2.45,-1.64,;-2.45,-3.2,;4.31,-5.16,;4.3,-3.63,)| Show InChI InChI=1S/C28H28F3N3O3S/c1-16-11-12-38-24(16)13-32-17(2)14-34-27(35)25(19-7-5-10-23(37-4)26(19)31)18(3)33(28(34)36)15-20-21(29)8-6-9-22(20)30/h5-12,17,32H,13-15H2,1-4H3/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...				J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109232 (7-(4-Acetylamino-phenyl)-6-[(benzyl-methyl-amino)-...) Show SMILES CCC(CC)OC(=O)c1cn(Cc2ccccc2F)c2cc(c(CN(C)Cc3ccccc3)n2c1=O)-c1ccc(NC(C)=O)cc1 Show InChI InChI=1S/C37H39FN4O4/c1-5-30(6-2)46-37(45)32-23-41(22-28-14-10-11-15-33(28)38)35-20-31(27-16-18-29(19-17-27)39-25(3)43)34(42(35)36(32)44)24-40(4)21-26-12-8-7-9-13-26/h7-20,23,30H,5-6,21-22,24H2,1-4H3,(H,39,43)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...				Bioorg Med Chem Lett 12: 403-6 (2002) BindingDB Entry DOI: 10.7270/Q2542MXV
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50140109 (1-(2,6-Difluoro-benzyl)-3-[(S)-2-(1-ethyl-propylam...) Show SMILES CCC(CC)N[C@@H](C)Cn1c(=O)c(c(C)n(Cc2c(F)cccc2F)c1=O)-c1cccc(OC)c1F |wU:6.6,(3.77,-1.23,;5.13,-.45,;6.48,-1.23,;7.83,-.43,;9.18,-1.22,;6.48,-2.8,;7.83,-3.56,;9.18,-2.78,;7.83,-5.13,;9.17,-5.91,;10.49,-5.13,;10.48,-3.59,;11.83,-5.88,;11.83,-7.42,;13.18,-8.18,;10.5,-8.2,;10.5,-9.74,;9.18,-10.53,;9.19,-12.04,;10.27,-13.13,;7.87,-12.82,;6.51,-12.07,;6.51,-10.53,;7.85,-9.74,;6.74,-8.65,;9.17,-7.45,;7.84,-8.2,;13.16,-5.1,;14.48,-5.88,;15.81,-5.09,;15.8,-3.55,;14.46,-2.8,;14.44,-1.23,;15.79,-.43,;13.13,-3.56,;11.78,-2.78,)| Show InChI InChI=1S/C27H32F3N3O3/c1-6-18(7-2)31-16(3)14-33-26(34)24(19-10-8-13-23(36-5)25(19)30)17(4)32(27(33)35)15-20-21(28)11-9-12-22(20)29/h8-13,16,18,31H,6-7,14-15H2,1-5H3/t16-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...				J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149262 (3-((R)-2-Cyclohexyl-2-dimethylamino-ethyl)-1-(2,6-...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](C2CCCCC2)N(C)C)c1=O |wU:26.35,(6.63,1.74,;5.3,.97,;5.3,-.57,;6.65,-1.34,;6.63,-2.89,;5.3,-3.65,;3.97,-2.88,;3.97,-1.34,;2.64,-.57,;2.64,-3.64,;2.64,-5.16,;3.97,-5.93,;1.29,-5.96,;1.29,-7.5,;2.62,-8.26,;2.62,-9.81,;1.29,-10.58,;3.95,-10.58,;5.3,-9.81,;5.3,-8.26,;3.95,-7.47,;5.05,-6.39,;-.04,-5.18,;-.05,-6.68,;-.04,-3.62,;-1.37,-2.85,;-2.7,-3.62,;-2.7,-5.16,;-1.37,-5.93,;-1.38,-7.47,;-2.72,-8.24,;-4.05,-7.47,;-4.03,-5.93,;-4.03,-2.85,;-5.36,-3.62,;-4.03,-1.31,;1.31,-2.85,;1.31,-1.31,)| Show InChI InChI=1S/C29H34F3N3O3/c1-18-26(20-12-8-15-25(38-4)27(20)32)28(36)35(17-24(33(2)3)19-10-6-5-7-11-19)29(37)34(18)16-21-22(30)13-9-14-23(21)31/h8-9,12-15,19,24H,5-7,10-11,16-17H2,1-4H3/t24-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50127179 (2-{8-(2-Fluoro-benzyl)-6-(3-methoxy-phenyl)-7-meth...) Show SMILES COC(=O)C(C)(C)c1nc2n(Cc3ccccc3F)c(C)c(-c3cccc(OC)c3)c(=O)n2c1CN(C)Cc1ccccn1 Show InChI InChI=1S/C34H36FN5O4/c1-22-29(23-13-11-15-26(18-23)43-5)31(41)40-28(21-38(4)20-25-14-9-10-17-36-25)30(34(2,3)32(42)44-6)37-33(40)39(22)19-24-12-7-8-16-27(24)35/h7-18H,19-21H2,1-6H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity against human gonadotropin-releasing hormone receptor				J Med Chem 46: 1769-72 (2003) Article DOI: 10.1021/jm0205402 BindingDB Entry DOI: 10.7270/Q2474983
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50140103 ((S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)NC2CCCC2)c1=O |wU:26.28,(10.27,.16,;8.93,-.64,;8.94,-2.2,;10.29,-2.96,;10.31,-4.5,;8.98,-5.28,;7.64,-4.51,;7.63,-2.97,;6.5,-1.86,;6.31,-5.29,;6.33,-6.83,;7.66,-7.59,;5,-7.61,;5,-9.15,;3.66,-9.93,;3.68,-11.45,;4.75,-12.54,;2.35,-12.23,;1,-11.47,;1,-9.93,;2.33,-9.15,;1.23,-8.05,;3.66,-6.85,;2.33,-7.61,;3.66,-5.31,;2.32,-4.53,;2.32,-2.97,;3.67,-2.19,;.96,-2.2,;.96,-.64,;-.3,.28,;.17,1.77,;1.74,1.77,;2.23,.28,;4.98,-4.53,;4.96,-2.99,)| Show InChI InChI=1S/C27H30F3N3O3/c1-16(31-18-8-4-5-9-18)14-33-26(34)24(19-10-6-13-23(36-3)25(19)30)17(2)32(27(33)35)15-20-21(28)11-7-12-22(20)29/h6-7,10-13,16,18,31H,4-5,8-9,14-15H2,1-3H3/t16-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...				J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50140103 ((S)-1-(2,6-difluorobenzyl)-3-(2-(cyclopentylamino)...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)NC2CCCC2)c1=O |wU:26.28,(10.27,.16,;8.93,-.64,;8.94,-2.2,;10.29,-2.96,;10.31,-4.5,;8.98,-5.28,;7.64,-4.51,;7.63,-2.97,;6.5,-1.86,;6.31,-5.29,;6.33,-6.83,;7.66,-7.59,;5,-7.61,;5,-9.15,;3.66,-9.93,;3.68,-11.45,;4.75,-12.54,;2.35,-12.23,;1,-11.47,;1,-9.93,;2.33,-9.15,;1.23,-8.05,;3.66,-6.85,;2.33,-7.61,;3.66,-5.31,;2.32,-4.53,;2.32,-2.97,;3.67,-2.19,;.96,-2.2,;.96,-.64,;-.3,.28,;.17,1.77,;1.74,1.77,;2.23,.28,;4.98,-4.53,;4.96,-2.99,)| Show InChI InChI=1S/C27H30F3N3O3/c1-16(31-18-8-4-5-9-18)14-33-26(34)24(19-10-6-13-23(36-3)25(19)30)17(2)32(27(33)35)15-20-21(28)11-7-12-22(20)29/h6-7,10-13,16,18,31H,4-5,8-9,14-15H2,1-3H3/t16-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50116238 (8-(2-Fluoro-benzyl)-2-(4-methoxy-phenyl)-6-(3-meth...) Show SMILES COc1ccc(cc1)-c1nc2n(Cc3ccccc3F)c(C)c(-c3cccc(OC)c3)c(=O)n2c1CN(C)CCc1ccccn1 Show InChI InChI=1S/C37H36FN5O3/c1-25-34(27-11-9-13-31(22-27)46-4)36(44)43-33(24-41(2)21-19-29-12-7-8-20-39-29)35(26-15-17-30(45-3)18-16-26)40-37(43)42(25)23-28-10-5-6-14-32(28)38/h5-18,20,22H,19,21,23-24H2,1-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding evaluated in cloned human Gonadotropin-releasing hormone receptor by displacement of [125 I-Tyr, DLeu, NMeLeu, Pro-NEt]GnRH agonist				Bioorg Med Chem Lett 12: 2185-7 (2002) BindingDB Entry DOI: 10.7270/Q2513XJ0
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50116238 (8-(2-Fluoro-benzyl)-2-(4-methoxy-phenyl)-6-(3-meth...) Show SMILES COc1ccc(cc1)-c1nc2n(Cc3ccccc3F)c(C)c(-c3cccc(OC)c3)c(=O)n2c1CN(C)CCc1ccccn1 Show InChI InChI=1S/C37H36FN5O3/c1-25-34(27-11-9-13-31(22-27)46-4)36(44)43-33(24-41(2)21-19-29-12-7-8-20-39-29)35(26-15-17-30(45-3)18-16-26)40-37(43)42(25)23-28-10-5-6-14-32(28)38/h5-18,20,22H,19,21,23-24H2,1-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity of the compound to human Gonadotropin-releasing hormone receptor				J Med Chem 46: 1769-72 (2003) Article DOI: 10.1021/jm0205402 BindingDB Entry DOI: 10.7270/Q2474983
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50132726 ((R)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-m...) Show SMILES COc1cccc(c1)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](C)N(C)Cc2ccccn2)c1=O |r| Show InChI InChI=1S/C29H30F2N4O3/c1-19(33(3)17-22-10-5-6-14-32-22)16-35-28(36)27(21-9-7-11-23(15-21)38-4)20(2)34(29(35)37)18-24-25(30)12-8-13-26(24)31/h5-15,19H,16-18H2,1-4H3/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards cloned human Gonadotropin-releasing hormone receptor expressed in RBL cells was determined by using [125I]-GnRH as radioliga...				Bioorg Med Chem Lett 14: 4967-73 (2004) Article DOI: 10.1016/j.bmcl.2004.07.022 BindingDB Entry DOI: 10.7270/Q2FF3RT4
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50132732 ((S)-1-(2,6-difluorobenzyl)-5-(3-methoxyphenyl)-6-m...) Show SMILES COc1cccc(c1)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)N(C)CCc2ccccn2)c1=O |r| Show InChI InChI=1S/C30H32F2N4O3/c1-20(34(3)16-14-23-10-5-6-15-33-23)18-36-29(37)28(22-9-7-11-24(17-22)39-4)21(2)35(30(36)38)19-25-26(31)12-8-13-27(25)32/h5-13,15,17,20H,14,16,18-19H2,1-4H3/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin-releasing hormone receptor expressed in HEK293 cells				Bioorg Med Chem Lett 13: 3317-22 (2003) BindingDB Entry DOI: 10.7270/Q2P26XJ4
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50140101 (3-[2-((S)-Cyclobutylamino)-propyl]-1-(2,6-difluoro...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(CC(C)NC2CCC2)c1=O |(-.51,5.44,;.83,4.67,;.83,3.13,;-.51,2.35,;-.51,.8,;.83,.04,;2.16,.81,;2.16,2.35,;3.51,3.13,;3.49,.04,;3.49,-1.52,;2.16,-2.29,;4.84,-2.29,;4.85,-3.83,;6.18,-4.61,;6.18,-6.15,;4.85,-6.92,;7.51,-6.91,;8.85,-6.13,;8.85,-4.59,;7.51,-3.82,;8.93,-3.02,;6.17,-1.5,;7.51,-2.28,;6.16,.04,;7.49,.82,;8.84,.05,;10.17,.83,;10.11,-1.22,;11.44,-.43,;12.21,-1.76,;13.55,-.99,;12.77,.35,;4.82,.81,;4.82,2.35,)| Show InChI InChI=1S/C26H28F3N3O3/c1-15(30-17-7-4-8-17)13-32-25(33)23(18-9-5-12-22(35-3)24(18)29)16(2)31(26(32)34)14-19-20(27)10-6-11-21(19)28/h5-6,9-12,15,17,30H,4,7-8,13-14H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...				J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50127199 (2-tert-Butyl-8-(2-fluoro-benzyl)-6-(3-methoxy-phen...) Show SMILES COc1cccc(c1)-c1c(C)n(Cc2ccccc2F)c2nc(c(CN(C)CCc3ccccn3)n2c1=O)C(C)(C)C Show InChI InChI=1S/C34H38FN5O2/c1-23-30(24-13-11-15-27(20-24)42-6)32(41)40-29(22-38(5)19-17-26-14-9-10-18-36-26)31(34(2,3)4)37-33(40)39(23)21-25-12-7-8-16-28(25)35/h7-16,18,20H,17,19,21-22H2,1-6H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity against human gonadotropin-releasing hormone receptor				J Med Chem 46: 1769-72 (2003) Article DOI: 10.1021/jm0205402 BindingDB Entry DOI: 10.7270/Q2474983
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109249 (7-(4-Butyrylamino-phenyl)-6-{[(2-diethylamino-ethy...) Show SMILES CCCC(=O)Nc1ccc(cc1)-c1cc2n(Cc3ccccc3F)cc(C(=O)OC(CC)CC)c(=O)n2c1CN(C)CCN(CC)CC Show InChI InChI=1S/C38H50FN5O4/c1-7-14-35(45)40-29-19-17-27(18-20-29)31-23-36-43(24-28-15-12-13-16-33(28)39)25-32(38(47)48-30(8-2)9-3)37(46)44(36)34(31)26-41(6)21-22-42(10-4)11-5/h12-13,15-20,23,25,30H,7-11,14,21-22,24,26H2,1-6H3,(H,40,45)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...				Bioorg Med Chem Lett 12: 403-6 (2002) BindingDB Entry DOI: 10.7270/Q2542MXV
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149269 (3-((R)-2-Amino-4-methyl-pentyl)-1-(2,6-difluoro-be...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)CC(C)C)c1=O |wU:26.28,(12.16,6.15,;10.83,5.38,;10.83,3.84,;12.18,3.07,;12.16,1.52,;10.83,.76,;9.5,1.53,;9.5,3.07,;8.17,3.84,;8.17,.77,;8.17,-.75,;9.5,-1.52,;6.82,-1.55,;6.82,-3.09,;8.15,-3.85,;9.48,-3.08,;10.58,-1.98,;10.83,-3.85,;10.83,-5.4,;9.48,-6.17,;8.15,-5.4,;6.82,-6.17,;5.49,-.77,;4.16,-1.52,;5.49,.79,;4.16,1.56,;2.83,.79,;1.5,1.56,;2.83,-.75,;1.49,-1.52,;.16,-.75,;1.48,-3.06,;6.84,1.56,;6.84,3.1,)| Show InChI InChI=1S/C25H28F3N3O3/c1-14(2)11-16(29)12-31-24(32)22(17-7-5-10-21(34-4)23(17)28)15(3)30(25(31)33)13-18-19(26)8-6-9-20(18)27/h5-10,14,16H,11-13,29H2,1-4H3/t16-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149252 (3-((R)-2-Amino-2-cyclohexyl-ethyl)-1-(2,6-difluoro...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)C2CCCCC2)c1=O |wU:26.28,(3.3,5.29,;1.97,4.52,;1.97,2.98,;3.31,2.21,;3.3,.65,;1.97,-.1,;.64,.67,;.64,2.21,;-.69,2.98,;-.7,-.09,;-.7,-1.62,;.63,-2.39,;-2.05,-2.41,;-2.05,-3.95,;-.72,-4.71,;-.72,-6.26,;-2.05,-7.03,;.61,-7.03,;1.96,-6.26,;1.96,-4.71,;.61,-3.94,;1.71,-2.85,;-3.38,-1.63,;-3.38,-3.13,;-3.38,-.08,;-4.71,.69,;-6.04,-.08,;-7.37,.69,;-6.04,-1.62,;-4.71,-2.39,;-4.73,-3.94,;-6.06,-4.7,;-7.39,-3.92,;-7.39,-2.39,;-2.03,.69,;-2.02,2.23,)| Show InChI InChI=1S/C27H30F3N3O3/c1-16-24(18-10-6-13-23(36-2)25(18)30)26(34)33(15-22(31)17-8-4-3-5-9-17)27(35)32(16)14-19-20(28)11-7-12-21(19)29/h6-7,10-13,17,22H,3-5,8-9,14-15,31H2,1-2H3/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50140115 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n([C@H](C)CNCc2ccccc2C)c1=O |wD:25.27,(8.37,1.48,;7.04,.68,;7.05,-.88,;8.38,-1.64,;8.41,-3.17,;7.08,-3.95,;5.76,-3.17,;5.74,-1.65,;4.37,-.87,;4.43,-3.95,;4.44,-5.5,;5.78,-6.26,;3.12,-6.26,;3.12,-7.79,;1.79,-8.57,;.47,-7.79,;-.63,-6.71,;-.86,-8.57,;-.86,-10.1,;.48,-10.86,;1.8,-10.1,;2.89,-11.18,;1.78,-5.5,;.46,-6.27,;1.78,-3.97,;.46,-3.21,;-.89,-3.99,;.46,-1.65,;-.9,-.88,;-.9,.68,;.46,1.46,;1.79,.68,;3.14,1.45,;3.14,3.01,;1.78,3.79,;.43,3.01,;-.91,3.79,;3.1,-3.19,;3.09,-1.66,)| Show InChI InChI=1S/C30H30F3N3O3/c1-18-9-5-6-10-21(18)16-34-15-19(2)36-29(37)27(22-11-7-14-26(39-4)28(22)33)20(3)35(30(36)38)17-23-24(31)12-8-13-25(23)32/h5-14,19,34H,15-17H2,1-4H3/t19-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...				J Med Chem 47: 1259-71 (2004) Article DOI: 10.1021/jm030472z BindingDB Entry DOI: 10.7270/Q2KD1ZNH
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50152717 ((4-{4-[3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-diflu...) Show SMILES CCOC(=O)Nc1ccc(cc1)-c1nc(cs1)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)c2ccccc2)c1=O Show InChI InChI=1S/C32H29F2N5O4S/c1-3-43-31(41)36-22-14-12-21(13-15-22)29-37-27(18-44-29)28-19(2)38(16-23-24(33)10-7-11-25(23)34)32(42)39(30(28)40)17-26(35)20-8-5-4-6-9-20/h4-15,18,26H,3,16-17,35H2,1-2H3,(H,36,41)/t26-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards cloned human Gonadotropin-releasing hormone receptor expressed in RBL cells was determined by using [125I]-GnRH as radioliga...				Bioorg Med Chem Lett 14: 4967-73 (2004) Article DOI: 10.1016/j.bmcl.2004.07.022 BindingDB Entry DOI: 10.7270/Q2FF3RT4
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50116222 (2-(4-Butyrylamino-phenyl)-8-(2-fluoro-benzyl)-3-{[...) Show SMILES CCCC(=O)Nc1ccc(cc1)-c1nc2n(Cc3ccccc3F)cc(C(=O)OC(CC)CC)c(=O)n2c1CN(C)CCc1ccccn1 Show InChI InChI=1S/C38H43FN6O4/c1-5-12-34(46)41-29-18-16-26(17-19-29)35-33(25-43(4)22-20-28-14-10-11-21-40-28)45-36(47)31(37(48)49-30(6-2)7-3)24-44(38(45)42-35)23-27-13-8-9-15-32(27)39/h8-11,13-19,21,24,30H,5-7,12,20,22-23,25H2,1-4H3,(H,41,46)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Ability to inhibit [I125-Tyr5,DLeu6,NMeLeu7,Pro9-NEt]GnRH agonist binding to the cloned human Gonadotropin-releasing hormone receptor was evaluated				Bioorg Med Chem Lett 12: 2179-83 (2002) BindingDB Entry DOI: 10.7270/Q28S4P8D
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50116222 (2-(4-Butyrylamino-phenyl)-8-(2-fluoro-benzyl)-3-{[...) Show SMILES CCCC(=O)Nc1ccc(cc1)-c1nc2n(Cc3ccccc3F)cc(C(=O)OC(CC)CC)c(=O)n2c1CN(C)CCc1ccccn1 Show InChI InChI=1S/C38H43FN6O4/c1-5-12-34(46)41-29-18-16-26(17-19-29)35-33(25-43(4)22-20-28-14-10-11-21-40-28)45-36(47)31(37(48)49-30(6-2)7-3)24-44(38(45)42-35)23-27-13-8-9-15-32(27)39/h8-11,13-19,21,24,30H,5-7,12,20,22-23,25H2,1-4H3,(H,41,46)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding evaluated in cloned human Gonadotropin-releasing hormone receptor by displacement of [125 I-Tyr, DLeu, NMeLeu, Pro-NEt]GnRH agonist				Bioorg Med Chem Lett 12: 2185-7 (2002) BindingDB Entry DOI: 10.7270/Q2513XJ0
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50127196 (2-tert-Butyl-3-{[ethyl-(2-pyridin-2-yl-ethyl)-amin...) Show SMILES CCN(CCc1ccccn1)Cc1c(nc2n(Cc3ccccc3F)c(C)c(-c3cccc(OC)c3)c(=O)n12)C(C)(C)C Show InChI InChI=1S/C35H40FN5O2/c1-7-39(20-18-27-15-10-11-19-37-27)23-30-32(35(3,4)5)38-34-40(22-26-13-8-9-17-29(26)36)24(2)31(33(42)41(30)34)25-14-12-16-28(21-25)43-6/h8-17,19,21H,7,18,20,22-23H2,1-6H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity against human gonadotropin-releasing hormone receptor				J Med Chem 46: 1769-72 (2003) Article DOI: 10.1021/jm0205402 BindingDB Entry DOI: 10.7270/Q2474983
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149256 (1-(2,6-Difluoro-benzyl)-3-((S)-2-dimethylamino-3-p...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](Cc2ccccc2)N(C)C)c1=O |wD:26.36,(12.82,6.04,;11.49,5.27,;11.49,3.73,;12.83,2.96,;12.82,1.42,;11.49,.65,;10.16,1.42,;10.16,2.96,;8.83,3.73,;8.82,.67,;8.82,-.87,;10.15,-1.64,;7.47,-1.66,;7.47,-3.2,;8.8,-3.95,;10.13,-3.18,;11.23,-2.08,;11.48,-3.95,;11.48,-5.51,;10.13,-6.28,;8.8,-5.51,;7.47,-6.28,;6.14,-.87,;4.81,-1.64,;6.14,.67,;4.81,1.44,;3.48,.68,;3.48,-.86,;2.15,-1.63,;.82,-.85,;-.51,-1.61,;-.53,-3.15,;.82,-3.93,;2.15,-3.16,;2.15,1.45,;.82,.69,;2.15,2.99,;7.49,1.44,;7.5,2.98,)| Show InChI InChI=1S/C30H30F3N3O3/c1-19-27(22-12-8-15-26(39-4)28(22)33)29(37)36(17-21(34(2)3)16-20-10-6-5-7-11-20)30(38)35(19)18-23-24(31)13-9-14-25(23)32/h5-15,21H,16-18H2,1-4H3/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50127195 (8-(2-Fluoro-benzyl)-2-(2-hydroxy-1,1-dimethyl-ethy...) Show SMILES COc1cccc(c1)-c1c(C)n(Cc2ccccc2F)c2nc(c(CN(C)Cc3ccccn3)n2c1=O)C(C)(C)CO Show InChI InChI=1S/C33H36FN5O3/c1-22-29(23-12-10-14-26(17-23)42-5)31(41)39-28(20-37(4)19-25-13-8-9-16-35-25)30(33(2,3)21-40)36-32(39)38(22)18-24-11-6-7-15-27(24)34/h6-17,40H,18-21H2,1-5H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity against human gonadotropin-releasing hormone receptor				J Med Chem 46: 1769-72 (2003) Article DOI: 10.1021/jm0205402 BindingDB Entry DOI: 10.7270/Q2474983
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149254 ((S)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyph...) Show SMILES CN[C@@H](Cc1ccccc1)Cn1c(=O)c(c(C)n(Cc2c(F)cccc2F)c1=O)-c1cccc(OC)c1F |r,wU:2.1,(24.86,-2.08,;26.19,-1.31,;26.19,.23,;24.85,1,;24.85,2.54,;26.18,3.31,;26.18,4.85,;24.84,5.62,;23.5,4.83,;23.51,3.3,;27.52,1.01,;28.86,.24,;30.18,1.02,;30.18,2.56,;31.51,.24,;31.51,-1.3,;32.85,-2.07,;30.18,-2.06,;30.18,-3.6,;31.52,-4.37,;32.84,-3.6,;31.5,-2.83,;34.17,-4.36,;34.18,-5.91,;32.84,-6.68,;31.51,-5.91,;30.17,-6.68,;28.86,-1.3,;27.52,-2.07,;32.85,1.01,;34.17,.23,;35.51,.99,;35.52,2.53,;34.17,3.31,;34.17,4.85,;35.51,5.62,;32.84,2.54,;31.51,3.3,)| Show InChI InChI=1S/C29H28F3N3O3/c1-18-26(21-11-7-14-25(38-3)27(21)32)28(36)35(16-20(33-2)15-19-9-5-4-6-10-19)29(37)34(18)17-22-23(30)12-8-13-24(22)31/h4-14,20,33H,15-17H2,1-3H3/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50152727 (3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-benzyl-thiazol...) Show SMILES Cc1c(-c2csc(Cc3ccccc3)n2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F Show InChI InChI=1S/C30H26F2N4O2S/c1-19-28(26-18-39-27(34-26)15-20-9-4-2-5-10-20)29(37)36(17-25(33)21-11-6-3-7-12-21)30(38)35(19)16-22-23(31)13-8-14-24(22)32/h2-14,18,25H,15-17,33H2,1H3/t25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards cloned human Gonadotropin-releasing hormone receptor expressed in RBL cells was determined by using [125I]-GnRH as radioliga...				Bioorg Med Chem Lett 14: 4967-73 (2004) Article DOI: 10.1016/j.bmcl.2004.07.022 BindingDB Entry DOI: 10.7270/Q2FF3RT4
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50121188 (8-Fluoro-1-(2-fluoro-benzyl)-7-(4-isobutoxy-phenyl...) Show SMILES CCOC(=O)c1cn(Cc2ccccc2F)c2c(F)c(c(CN(C)CCc3ccccn3)n2c1=O)-c1ccc(OCC(C)C)cc1 Show InChI InChI=1S/C36H38F2N4O4/c1-5-45-36(44)29-21-41(20-26-10-6-7-12-30(26)37)34-33(38)32(25-13-15-28(16-14-25)46-23-24(2)3)31(42(34)35(29)43)22-40(4)19-17-27-11-8-9-18-39-27/h6-16,18,21,24H,5,17,19-20,22-23H2,1-4H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity of the compound towards human Gonadotropin-releasing hormone receptor				Bioorg Med Chem Lett 12: 3491-5 (2002) BindingDB Entry DOI: 10.7270/Q2M90812
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109247 (7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[...) Show SMILES CCCC(=O)Nc1ccc(cc1)-c1cc2n(Cc3ccccc3F)cc(C(=O)NC3CCCC3)c(=O)n2c1CN(C)CCc1ccccn1 Show InChI InChI=1S/C39H43FN6O3/c1-3-10-36(47)42-31-18-16-27(17-19-31)32-23-37-45(24-28-11-4-7-15-34(28)40)25-33(38(48)43-30-13-5-6-14-30)39(49)46(37)35(32)26-44(2)22-20-29-12-8-9-21-41-29/h4,7-9,11-12,15-19,21,23,25,30H,3,5-6,10,13-14,20,22,24,26H2,1-2H3,(H,42,47)(H,43,48)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	9.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...				Bioorg Med Chem Lett 12: 403-6 (2002) BindingDB Entry DOI: 10.7270/Q2542MXV
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149258 (3-((R)-2-Amino-2-cyclopentyl-ethyl)-1-(2,6-difluor...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)C2CCCC2)c1=O |wU:26.28,(3.3,5.29,;1.97,4.52,;1.97,2.98,;3.31,2.21,;3.3,.65,;1.97,-.1,;.64,.67,;.64,2.21,;-.69,2.98,;-.7,-.09,;-.7,-1.62,;.63,-2.39,;-2.05,-2.41,;-2.05,-3.95,;-.72,-4.71,;-.72,-6.26,;-2.05,-7.03,;.61,-7.03,;1.96,-6.26,;1.96,-4.71,;.61,-3.94,;1.71,-2.85,;-3.38,-1.63,;-3.38,-3.13,;-3.38,-.08,;-4.71,.69,;-6.04,-.08,;-7.37,.69,;-6.04,-1.62,;-4.8,-2.53,;-5.29,-3.99,;-6.83,-3.97,;-7.3,-2.52,;-2.03,.69,;-2.02,2.23,)| Show InChI InChI=1S/C26H28F3N3O3/c1-15-23(17-9-5-12-22(35-2)24(17)29)25(33)32(14-21(30)16-7-3-4-8-16)26(34)31(15)13-18-19(27)10-6-11-20(18)28/h5-6,9-12,16,21H,3-4,7-8,13-14,30H2,1-2H3/t21-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50109251 (7-(4-Butyrylamino-phenyl)-1-(2-fluoro-benzyl)-6-{[...) Show SMILES CCCCNC(=O)c1cn(Cc2ccccc2F)c2cc(c(CN(C)CCc3ccccn3)n2c1=O)-c1ccc(NC(=O)CCC)cc1 Show InChI InChI=1S/C38H43FN6O3/c1-4-6-20-41-37(47)32-25-44(24-28-12-7-8-14-33(28)39)36-23-31(27-15-17-30(18-16-27)42-35(46)11-5-2)34(45(36)38(32)48)26-43(3)22-19-29-13-9-10-21-40-29/h7-10,12-18,21,23,25H,4-6,11,19-20,22,24,26H2,1-3H3,(H,41,47)(H,42,46)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human gonadotropin-releasing hormone (hGnRH) receptor expressed in HEK293 cells using des-Gly10[125I-Tyr,5DLeu,6NMeLeu,7Pro9-NEt]...				Bioorg Med Chem Lett 12: 403-6 (2002) BindingDB Entry DOI: 10.7270/Q2542MXV
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50152711 (3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...) Show SMILES Cc1c(-c2cccs2)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F Show InChI InChI=1S/C24H21F2N3O2S/c1-15-22(21-11-6-12-32-21)23(30)29(14-20(27)16-7-3-2-4-8-16)24(31)28(15)13-17-18(25)9-5-10-19(17)26/h2-12,20H,13-14,27H2,1H3/t20-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards cloned human Gonadotropin-releasing hormone receptor expressed in RBL cells was determined by using [125I]-GnRH as radioliga...				Bioorg Med Chem Lett 14: 4967-73 (2004) Article DOI: 10.1016/j.bmcl.2004.07.022 BindingDB Entry DOI: 10.7270/Q2FF3RT4
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50127187 (2-tert-Butyl-8-(2-fluoro-benzyl)-6-(3-methoxy-phen...) Show SMILES COc1cccc(c1)-c1c(C)n(Cc2ccccc2F)c2nc(c(CN(C)Cc3ccccn3)n2c1=O)C(C)(C)C Show InChI InChI=1S/C33H36FN5O2/c1-22-29(23-13-11-15-26(18-23)41-6)31(40)39-28(21-37(5)20-25-14-9-10-17-35-25)30(33(2,3)4)36-32(39)38(22)19-24-12-7-8-16-27(24)34/h7-18H,19-21H2,1-6H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity against human gonadotropin-releasing hormone receptor				J Med Chem 46: 1769-72 (2003) Article DOI: 10.1021/jm0205402 BindingDB Entry DOI: 10.7270/Q2474983
					More data for this Ligand-Target Pair

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