Found 435 hits with Last Name = 'cooper' and Initial = 'n' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218255
(CHEMBL290100)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(C)=O Show InChI InChI=1S/C17H12Cl2N2O4/c1-8(22)14-5-10-9(3-4-13(24-2)16(10)25-14)17(23)21-15-11(18)6-20-7-12(15)19/h3-7H,1-2H3,(H,20,21,23) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R&D
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cells |
Bioorg Med Chem Lett 12: 1613-5 (2002)
BindingDB Entry DOI: 10.7270/Q2D220S3 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218255
(CHEMBL290100)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(C)=O Show InChI InChI=1S/C17H12Cl2N2O4/c1-8(22)14-5-10-9(3-4-13(24-2)16(10)25-14)17(23)21-15-11(18)6-20-7-12(15)19/h3-7H,1-2H3,(H,20,21,23) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218257
(CHEMBL69874)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(=O)c1ccncc1 Show InChI InChI=1S/C21H13Cl2N3O4/c1-29-16-3-2-12(21(28)26-18-14(22)9-25-10-15(18)23)13-8-17(30-20(13)16)19(27)11-4-6-24-7-5-11/h2-10H,1H3,(H,25,26,28) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human)) | BDBM7672
(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)Show SMILES CNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3cccnn23)cc1 Show InChI InChI=1S/C17H15N7O2S/c1-18-27(25,26)13-6-4-12(5-7-13)22-17-19-10-8-14(23-17)15-11-20-16-3-2-9-21-24(15)16/h2-11,18H,1H3,(H,19,22,23) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca
| Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. |
Bioorg Med Chem Lett 14: 2249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.008 BindingDB Entry DOI: 10.7270/Q2XG9PCF |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human)) | BDBM7673
(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)Show SMILES COCCNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3cccnn23)cc1 Show InChI InChI=1S/C19H19N7O3S/c1-29-12-11-23-30(27,28)15-6-4-14(5-7-15)24-19-20-10-8-16(25-19)17-13-21-18-3-2-9-22-26(17)18/h2-10,13,23H,11-12H2,1H3,(H,20,24,25) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca
| Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. |
Bioorg Med Chem Lett 14: 2249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.008 BindingDB Entry DOI: 10.7270/Q2XG9PCF |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human)) | BDBM7671
(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)Show SMILES NS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3cccnn23)cc1 Show InChI InChI=1S/C16H13N7O2S/c17-26(24,25)12-5-3-11(4-6-12)21-16-18-9-7-13(22-16)14-10-19-15-2-1-8-20-23(14)15/h1-10H,(H2,17,24,25)(H,18,21,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca
| Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. |
Bioorg Med Chem Lett 14: 2249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.008 BindingDB Entry DOI: 10.7270/Q2XG9PCF |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human)) | BDBM7667
(4-[(4-{6-bromoimidazo[1,2-a]pyridin-3-yl}pyrimidin...)Show SMILES COCCNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3ccc(Br)cn23)cc1 Show InChI InChI=1S/C20H19BrN6O3S/c1-30-11-10-24-31(28,29)16-5-3-15(4-6-16)25-20-22-9-8-17(26-20)18-12-23-19-7-2-14(21)13-27(18)19/h2-9,12-13,24H,10-11H2,1H3,(H,22,25,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca
| Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. |
Bioorg Med Chem Lett 14: 2249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.008 BindingDB Entry DOI: 10.7270/Q2XG9PCF |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human)) | BDBM7669
(4-({4-[6-(ethylsulfanyl)imidazo[1,2-a]pyridin-3-yl...)Show SMILES CCSc1ccc2ncc(-c3ccnc(Nc4ccc(cc4)S(=O)(=O)NCCOC)n3)n2c1 Show InChI InChI=1S/C22H24N6O3S2/c1-3-32-17-6-9-21-24-14-20(28(21)15-17)19-10-11-23-22(27-19)26-16-4-7-18(8-5-16)33(29,30)25-12-13-31-2/h4-11,14-15,25H,3,12-13H2,1-2H3,(H,23,26,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca
| Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. |
Bioorg Med Chem Lett 14: 2249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.008 BindingDB Entry DOI: 10.7270/Q2XG9PCF |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human)) | BDBM7668
(4-[(4-{6-cyanoimidazo[1,2-a]pyridin-3-yl}pyrimidin...)Show SMILES COCCNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3ccc(cn23)C#N)cc1 Show InChI InChI=1S/C21H19N7O3S/c1-31-11-10-25-32(29,30)17-5-3-16(4-6-17)26-21-23-9-8-18(27-21)19-13-24-20-7-2-15(12-22)14-28(19)20/h2-9,13-14,25H,10-11H2,1H3,(H,23,26,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca
| Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. |
Bioorg Med Chem Lett 14: 2249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.008 BindingDB Entry DOI: 10.7270/Q2XG9PCF |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human)) | BDBM7679
(Imidazo[1,2-b]pyridazine deriv. 4b | N-(2-methoxye...)Show SMILES COCCNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2c(C)nc3cccnn23)cc1 Show InChI InChI=1S/C20H21N7O3S/c1-14-19(27-18(24-14)4-3-10-22-27)17-9-11-21-20(26-17)25-15-5-7-16(8-6-15)31(28,29)23-12-13-30-2/h3-11,23H,12-13H2,1-2H3,(H,21,25,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca
| Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. |
Bioorg Med Chem Lett 14: 2249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.008 BindingDB Entry DOI: 10.7270/Q2XG9PCF |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human)) | BDBM7675
(Imidazo[1,2-b]pyridazine deriv. 2e | N-[3-(dimethy...)Show SMILES CN(C)CCCNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3cccnn23)cc1 Show InChI InChI=1S/C21H24N8O2S/c1-28(2)14-4-12-25-32(30,31)17-8-6-16(7-9-17)26-21-22-13-10-18(27-21)19-15-23-20-5-3-11-24-29(19)20/h3,5-11,13,15,25H,4,12,14H2,1-2H3,(H,22,26,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | <3 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca
| Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. |
Bioorg Med Chem Lett 14: 2249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.008 BindingDB Entry DOI: 10.7270/Q2XG9PCF |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219014
(CHEMBL149559)Show SMILES CCc1cc2c(cnc(OC(F)F)c2o1)C(=O)Nc1c(Cl)c[n+]([O-])cc1Cl Show InChI InChI=1S/C16H11Cl2F2N3O4/c1-2-7-3-8-9(4-21-15(13(8)26-7)27-16(19)20)14(24)22-12-10(17)5-23(25)6-11(12)18/h3-6,16H,2H2,1H3,(H,22,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R& D
Curated by ChEMBL
| Assay Description Inhibition of human phosphodiesterase 4 from U937 cells |
Bioorg Med Chem Lett 12: 509-12 (2002)
BindingDB Entry DOI: 10.7270/Q2T43W9C |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218258
(CHEMBL70146)Show InChI InChI=1S/C17H13ClN2O4/c1-9(21)15-7-11-10(3-4-14(23-2)16(11)24-15)17(22)20-13-5-6-19-8-12(13)18/h3-8H,1-2H3,(H,19,20,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218245
(CHEMBL65799)Show InChI InChI=1S/C16H9Cl2N3O3/c1-23-13-3-2-9(10-4-8(5-19)24-15(10)13)16(22)21-14-11(17)6-20-7-12(14)18/h2-4,6-7H,1H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218245
(CHEMBL65799)Show InChI InChI=1S/C16H9Cl2N3O3/c1-23-13-3-2-9(10-4-8(5-19)24-15(10)13)16(22)21-14-11(17)6-20-7-12(14)18/h2-4,6-7H,1H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50114418
(8-Methoxy-2-trifluoromethyl-quinoline-5-carboxylic...)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C17H10Cl2F3N3O2/c1-27-12-4-2-9(8-3-5-13(17(20,21)22)24-14(8)12)16(26)25-15-10(18)6-23-7-11(15)19/h2-7H,1H3,(H,23,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to PDE4 of rat brain |
Bioorg Med Chem Lett 12: 1621-3 (2002)
BindingDB Entry DOI: 10.7270/Q24J0HB2 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human)) | BDBM7674
(CHEMBL484571 | Imidazo[1,2-b]pyridazine deriv. 2d ...)Show SMILES CN(C)CCNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3cccnn23)cc1 Show InChI InChI=1S/C20H22N8O2S/c1-27(2)13-12-24-31(29,30)16-7-5-15(6-8-16)25-20-21-11-9-17(26-20)18-14-22-19-4-3-10-23-28(18)19/h3-11,14,24H,12-13H2,1-2H3,(H,21,25,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca
| Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. |
Bioorg Med Chem Lett 14: 2249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.008 BindingDB Entry DOI: 10.7270/Q2XG9PCF |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218257
(CHEMBL69874)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(=O)c1ccncc1 Show InChI InChI=1S/C21H13Cl2N3O4/c1-29-16-3-2-12(21(28)26-18-14(22)9-25-10-15(18)23)13-8-17(30-20(13)16)19(27)11-4-6-24-7-5-11/h2-10H,1H3,(H,25,26,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218246
(CHEMBL68323)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(C)O Show InChI InChI=1S/C17H14Cl2N2O4/c1-8(22)14-5-10-9(3-4-13(24-2)16(10)25-14)17(23)21-15-11(18)6-20-7-12(15)19/h3-8,22H,1-2H3,(H,20,21,23) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50213867
(CHEMBL329303)Show SMILES COC(=O)c1cccc(c1)-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C20H16N4O4/c1-28-19(26)14-8-5-9-15(10-14)24-17-16(21-12-22-17)18(25)23(20(24)27)11-13-6-3-2-4-7-13/h2-10,12H,11H2,1H3,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding |
Bioorg Med Chem Lett 8: 2925-30 (1998)
BindingDB Entry DOI: 10.7270/Q2Z89FKG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219013
(CHEMBL343205)Show SMILES CCc1cc2c(cnc(OC)c2o1)C(=O)Nc1c(Cl)c[n+]([O-])cc1Cl Show InChI InChI=1S/C16H13Cl2N3O4/c1-3-8-4-9-10(5-19-16(24-2)14(9)25-8)15(22)20-13-11(17)6-21(23)7-12(13)18/h4-7H,3H2,1-2H3,(H,20,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R& D
Curated by ChEMBL
| Assay Description Inhibition of human phosphodiesterase 4 from U937 cells |
Bioorg Med Chem Lett 12: 509-12 (2002)
BindingDB Entry DOI: 10.7270/Q2T43W9C |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1
(Homo sapiens (Human)) | BDBM7670
(Imidazo[1,2-a]pyridine deriv. 4g | N-(2-methoxyeth...)Show SMILES COCCNS(=O)(=O)c1ccc(Nc2nccc(n2)-c2cnc3ccc(Sc4ccccc4)cn23)cc1 Show InChI InChI=1S/C26H24N6O3S2/c1-35-16-15-29-37(33,34)22-10-7-19(8-11-22)30-26-27-14-13-23(31-26)24-17-28-25-12-9-21(18-32(24)25)36-20-5-3-2-4-6-20/h2-14,17-18,29H,15-16H2,1H3,(H,27,30,31) | PDB
UniProtKB/SwissProt
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| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | 7.0 | 22 |
AstraZeneca
| Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. |
Bioorg Med Chem Lett 14: 2249-52 (2004)
Article DOI: 10.1016/j.bmcl.2004.02.008 BindingDB Entry DOI: 10.7270/Q2XG9PCF |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218249
(CHEMBL304051)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(CC(C)(C)C)oc12 Show InChI InChI=1S/C20H20Cl2N2O3/c1-20(2,3)8-11-7-13-12(5-6-16(26-4)18(13)27-11)19(25)24-17-14(21)9-23-10-15(17)22/h5-7,9-10H,8H2,1-4H3,(H,23,24,25) | PDB
UniProtKB/SwissProt
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| PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50214164
(CHEMBL100011)Show SMILES COc1cccc(c1)-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C19H16N4O3/c1-26-15-9-5-8-14(10-15)23-17-16(20-12-21-17)18(24)22(19(23)25)11-13-6-3-2-4-7-13/h2-10,12H,11H2,1H3,(H,20,21) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding |
Bioorg Med Chem Lett 8: 2925-30 (1998)
BindingDB Entry DOI: 10.7270/Q2Z89FKG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218246
(CHEMBL68323)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(C)O Show InChI InChI=1S/C17H14Cl2N2O4/c1-8(22)14-5-10-9(3-4-13(24-2)16(10)25-14)17(23)21-15-11(18)6-20-7-12(15)19/h3-8,22H,1-2H3,(H,20,21,23) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50219815
(CHEMBL43570)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2[nH]c(nc12)C(F)(F)F Show InChI InChI=1S/C15H9Cl2F3N4O2/c1-26-9-3-2-6(10-12(9)24-14(23-10)15(18,19)20)13(25)22-11-7(16)4-21-5-8(11)17/h2-5H,1H3,(H,23,24)(H,21,22,25) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R&D
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding in rat brain |
Bioorg Med Chem Lett 12: 1613-5 (2002)
BindingDB Entry DOI: 10.7270/Q2D220S3 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R&D
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding in rat brain |
Bioorg Med Chem Lett 12: 1613-5 (2002)
BindingDB Entry DOI: 10.7270/Q2D220S3 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R& D
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to rat brain |
Bioorg Med Chem Lett 12: 509-12 (2002)
BindingDB Entry DOI: 10.7270/Q2T43W9C |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218255
(CHEMBL290100)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(C)=O Show InChI InChI=1S/C17H12Cl2N2O4/c1-8(22)14-5-10-9(3-4-13(24-2)16(10)25-14)17(23)21-15-11(18)6-20-7-12(15)19/h3-7H,1-2H3,(H,20,21,23) | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R&D
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding in rat brain |
Bioorg Med Chem Lett 12: 1613-5 (2002)
BindingDB Entry DOI: 10.7270/Q2D220S3 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiroscience Ltd
Curated by ChEMBL
| Assay Description Relative inhibition of phosphodiesterase 4 activity and Rolipram binding to PDE4 |
Bioorg Med Chem Lett 8: 2635-40 (1999)
BindingDB Entry DOI: 10.7270/Q2MP52FN |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
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| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219018
(CHEMBL148584)Show SMILES COc1ncc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2cc(oc12)C1CCOC1 Show InChI InChI=1S/C18H15Cl2N3O5/c1-26-18-16-10(4-14(28-16)9-2-3-27-8-9)11(5-21-18)17(24)22-15-12(19)6-23(25)7-13(15)20/h4-7,9H,2-3,8H2,1H3,(H,22,24) | PDB
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
| PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R& D
Curated by ChEMBL
| Assay Description Inhibition of human phosphodiesterase 4 from U937 cells |
Bioorg Med Chem Lett 12: 509-12 (2002)
BindingDB Entry DOI: 10.7270/Q2T43W9C |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218259
(CHEMBL67898)Show InChI InChI=1S/C17H14Cl2N2O3/c1-3-9-6-11-10(4-5-14(23-2)16(11)24-9)17(22)21-15-12(18)7-20-8-13(15)19/h4-8H,3H2,1-2H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of Rolipram binding to PDE4 at 1 uM |
Bioorg Med Chem Lett 8: 2629-34 (1998)
BindingDB Entry DOI: 10.7270/Q2M32XZQ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50218259
(CHEMBL67898)Show InChI InChI=1S/C17H14Cl2N2O3/c1-3-9-6-11-10(4-5-14(23-2)16(11)24-9)17(22)21-15-12(18)7-20-8-13(15)19/h4-8H,3H2,1-2H3,(H,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50219014
(CHEMBL149559)Show SMILES CCc1cc2c(cnc(OC(F)F)c2o1)C(=O)Nc1c(Cl)c[n+]([O-])cc1Cl Show InChI InChI=1S/C16H11Cl2F2N3O4/c1-2-7-3-8-9(4-21-15(13(8)26-7)27-16(19)20)14(24)22-12-10(17)5-23(25)6-11(12)18/h3-6,16H,2H2,1H3,(H,22,24) | PDB
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| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R& D
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to rat brain |
Bioorg Med Chem Lett 12: 509-12 (2002)
BindingDB Entry DOI: 10.7270/Q2T43W9C |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218258
(CHEMBL70146)Show InChI InChI=1S/C17H13ClN2O4/c1-9(21)15-7-11-10(3-4-14(23-2)16(11)24-15)17(22)20-13-5-6-19-8-12(13)18/h3-8H,1-2H3,(H,19,20,22) | PDB
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| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding in rat brain tissue |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219830
(CHEMBL42387)Show SMILES COc1ccc(C(=O)Nc2c(F)cncc2F)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C17H10F5N3O2/c1-27-12-4-2-9(8-3-5-13(17(20,21)22)24-14(8)12)16(26)25-15-10(18)6-23-7-11(15)19/h2-7H,1H3,(H,23,25,26) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 12: 1621-3 (2002)
BindingDB Entry DOI: 10.7270/Q24J0HB2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50219830
(CHEMBL42387)Show SMILES COc1ccc(C(=O)Nc2c(F)cncc2F)c2ccc(nc12)C(F)(F)F Show InChI InChI=1S/C17H10F5N3O2/c1-27-12-4-2-9(8-3-5-13(17(20,21)22)24-14(8)12)16(26)25-15-10(18)6-23-7-11(15)19/h2-7H,1H3,(H,23,25,26) | PDB
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| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to PDE4 of rat brain |
Bioorg Med Chem Lett 12: 1621-3 (2002)
BindingDB Entry DOI: 10.7270/Q24J0HB2 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50214288
(CHEMBL98483)Show SMILES Clc1cccc(c1)-n1c2nc[nH]c2c(=O)n(Cc2ccccc2)c1=O Show InChI InChI=1S/C18H13ClN4O2/c19-13-7-4-8-14(9-13)23-16-15(20-11-21-16)17(24)22(18(23)25)10-12-5-2-1-3-6-12/h1-9,11H,10H2,(H,20,21) | PDB
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| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to PDE4 |
Bioorg Med Chem Lett 8: 2925-30 (1998)
BindingDB Entry DOI: 10.7270/Q2Z89FKG |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219821
(CHEMBL42002)Show InChI InChI=1S/C18H15Cl2N3O2/c1-3-10-4-5-11-12(6-7-15(25-2)16(11)22-10)18(24)23-17-13(19)8-21-9-14(17)20/h4-9H,3H2,1-2H3,(H,21,23,24) | PDB
UniProtKB/SwissProt
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Similars
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description Inhibition of Phosphodiesterase 4 from human U937 cells |
Bioorg Med Chem Lett 12: 1617-9 (2002)
BindingDB Entry DOI: 10.7270/Q289182S |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50219824
(CHEMBL444824)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2ccc(nc12)C#N Show InChI InChI=1S/C17H10Cl2N4O2/c1-25-14-5-4-11(10-3-2-9(6-20)22-15(10)14)17(24)23-16-12(18)7-21-8-13(16)19/h2-5,7-8H,1H3,(H,21,23,24) | PDB
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to PDE4 in rat brain |
Bioorg Med Chem Lett 12: 1617-9 (2002)
BindingDB Entry DOI: 10.7270/Q289182S |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
(Rattus norvegicus) | BDBM50218255
(CHEMBL290100)Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cc(oc12)C(C)=O Show InChI InChI=1S/C17H12Cl2N2O4/c1-8(22)14-5-10-9(3-4-13(24-2)16(10)25-14)17(23)21-15-11(18)6-20-7-12(15)19/h3-7H,1-2H3,(H,20,21,23) | PDB
UniProtKB/SwissProt
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech-Chiroscience Ltd
Curated by ChEMBL
| Assay Description Inhibition of rolipram binding to rat brain tissue at 20 uM |
Bioorg Med Chem Lett 10: 2137-40 (2000)
BindingDB Entry DOI: 10.7270/Q2NP26MQ |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219016
(CHEMBL149081)Show SMILES COCc1cc2c(cnc(OC)c2o1)C(=O)Nc1c(Cl)c[n+]([O-])cc1Cl Show InChI InChI=1S/C16H13Cl2N3O5/c1-24-7-8-3-9-10(4-19-16(25-2)14(9)26-8)15(22)20-13-11(17)5-21(23)6-12(13)18/h3-6H,7H2,1-2H3,(H,20,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R& D
Curated by ChEMBL
| Assay Description Inhibition of human phosphodiesterase 4 from U937 cells |
Bioorg Med Chem Lett 12: 509-12 (2002)
BindingDB Entry DOI: 10.7270/Q2T43W9C |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219009
(CHEMBL149777)Show SMILES COc1ncc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2cc(oc12)C1CCOCC1 Show InChI InChI=1S/C19H17Cl2N3O5/c1-27-19-17-11(6-15(29-17)10-2-4-28-5-3-10)12(7-22-19)18(25)23-16-13(20)8-24(26)9-14(16)21/h6-10H,2-5H2,1H3,(H,23,25) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R& D
Curated by ChEMBL
| Assay Description Inhibition of human phosphodiesterase 4 from U937 cells |
Bioorg Med Chem Lett 12: 509-12 (2002)
BindingDB Entry DOI: 10.7270/Q2T43W9C |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50219012
(CHEMBL359035)Show SMILES COc1ncc(C(=O)Nc2c(Cl)c[n+]([O-])cc2Cl)c2cc(oc12)C1(CCN(CC1)C(=O)OC(C)(C)C)OC Show InChI InChI=1S/C25H28Cl2N4O7/c1-24(2,3)38-23(33)30-8-6-25(36-5,7-9-30)18-10-14-15(11-28-22(35-4)20(14)37-18)21(32)29-19-16(26)12-31(34)13-17(19)27/h10-13H,6-9H2,1-5H3,(H,29,32) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Celltech R& D
Curated by ChEMBL
| Assay Description Inhibition of human phosphodiesterase 4 from U937 cells |
Bioorg Med Chem Lett 12: 509-12 (2002)
BindingDB Entry DOI: 10.7270/Q2T43W9C |
More data for this Ligand-Target Pair | |
Integrin alpha-V/beta-6
(Homo sapiens (Human)) | BDBM528326
(US11180494, Example 155B)Show SMILES Cc1cc(C)n(n1)C1CCCC1OC(=O)N[C@H](CCO[C@H]1C[C@H](CCc2ccc3CCCNc3n2)C1)C(O)=O |r,w:11.13,5.7,wU:22.24,wD:16.17,20.21,(-12.37,.63,;-11.6,1.96,;-12.08,3.43,;-10.83,4.33,;-10.83,5.87,;-9.59,3.43,;-10.06,1.96,;-8.1,3.82,;-7.62,5.29,;-6.08,5.29,;-5.61,3.82,;-6.85,2.92,;-6.85,1.38,;-5.52,.61,;-4.19,1.38,;-5.52,-.93,;-4.19,-1.7,;-2.85,-.93,;-1.52,-1.7,;-.18,-.93,;1.15,-1.7,;1.55,-3.19,;3.04,-2.79,;4.37,-3.56,;5.7,-2.79,;7.04,-3.56,;7.04,-5.1,;8.37,-5.87,;9.7,-5.1,;11.04,-5.87,;12.37,-5.1,;12.37,-3.56,;11.04,-2.79,;9.7,-3.56,;8.37,-2.79,;2.64,-1.3,;-4.19,-3.24,;-2.85,-4.01,;-5.52,-4.01,)| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The biochemical potency of compounds was determined using a proximity-based assay (ALPHASCREENŽ, Perkin Elmer, Waltham, Mass.) as described previousl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RC5 |
More data for this Ligand-Target Pair | |
Integrin alpha-V/beta-6
(Homo sapiens (Human)) | BDBM528289
(US11180494, Example 158)Show SMILES CC(C)c1ccc(cc1)C1(CN(C1)C(=O)OC(C)(C)C)OC(=O)NC(CCO[C@H]1C[C@H](CCc2ccc3CCCNc3n2)C1)C(O)=O |r,w:24.25,wU:30.32,wD:28.29,(-11.49,-3.49,;-11.49,-1.95,;-12.82,-1.18,;-10.16,-1.18,;-10.16,.36,;-8.82,1.13,;-7.49,.36,;-7.49,-1.18,;-8.82,-1.95,;-6.4,1.45,;-4.91,1.85,;-5.31,3.34,;-6.8,2.94,;-4.54,4.67,;-5.31,6,;-3,4.67,;-2.23,6,;-.69,6,;-3,7.34,;-1.46,7.34,;-6.4,-.09,;-5.07,-.86,;-3.73,-.09,;-5.07,-2.4,;-3.73,-3.17,;-2.4,-2.4,;-1.07,-3.17,;.27,-2.4,;1.6,-3.17,;2,-4.66,;3.49,-4.26,;4.82,-5.03,;6.16,-4.26,;7.49,-5.03,;7.49,-6.57,;8.82,-7.34,;10.16,-6.57,;11.49,-7.34,;12.82,-6.57,;12.82,-5.03,;11.49,-4.26,;10.16,-5.03,;8.82,-4.26,;3.09,-2.77,;-3.73,-4.71,;-5.07,-5.48,;-2.4,-5.48,)| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The biochemical potency of compounds was determined using a proximity-based assay (ALPHASCREENŽ, Perkin Elmer, Waltham, Mass.) as described previousl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RC5 |
More data for this Ligand-Target Pair | |
Integrin alpha-V/beta-6
(Homo sapiens (Human)) | BDBM528290
(US11180494, Example 159)Show SMILES CC(C)(C)OC(=O)N1CC(C1)(OC(=O)NC(CCO[C@H]1C[C@H](CCc2ccc3CCCNc3n2)C1)C(O)=O)C#Cc1ccccc1 |r,w:15.15,wU:21.22,wD:19.19,(-5.19,8,;-4.42,6.67,;-2.88,6.67,;-3.65,8,;-5.19,5.34,;-4.42,4,;-2.88,4,;-5.19,2.67,;-4.79,1.18,;-6.28,.78,;-6.68,2.27,;-6.28,-.76,;-4.94,-1.53,;-3.61,-.76,;-4.94,-3.07,;-3.61,-3.84,;-2.28,-3.07,;-.94,-3.84,;.39,-3.07,;1.72,-3.84,;2.12,-5.32,;3.61,-4.92,;4.94,-5.69,;6.28,-4.92,;7.61,-5.69,;7.61,-7.23,;8.94,-8,;10.28,-7.23,;11.61,-8,;12.95,-7.23,;12.95,-5.69,;11.61,-4.92,;10.28,-5.69,;8.94,-4.92,;3.21,-3.44,;-3.61,-5.38,;-2.28,-6.15,;-4.94,-6.15,;-7.61,.01,;-8.95,-.76,;-10.28,-1.53,;-11.61,-.76,;-12.95,-1.53,;-12.95,-3.07,;-11.61,-3.84,;-10.28,-3.07,)| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The biochemical potency of compounds was determined using a proximity-based assay (ALPHASCREENŽ, Perkin Elmer, Waltham, Mass.) as described previousl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RC5 |
More data for this Ligand-Target Pair | |
Integrin alpha-V/beta-6
(Homo sapiens (Human)) | BDBM528292
(US11180494, Example 161)Show SMILES OC(=O)C(CCO[C@H]1C[C@H](CCc2ccc3CCCNc3n2)C1)NC(=O)C1CCCC(F)(F)C1 |r,w:3.25,wU:9.9,wD:7.6,(-6.94,-3.59,;-5.61,-2.82,;-4.28,-3.59,;-5.61,-1.28,;-4.28,-.51,;-2.94,-1.28,;-1.61,-.51,;-.28,-1.28,;.12,-2.76,;1.61,-2.37,;2.94,-3.14,;4.28,-2.37,;5.61,-3.14,;5.61,-4.68,;6.94,-5.45,;8.28,-4.68,;9.61,-5.45,;10.95,-4.68,;10.95,-3.14,;9.61,-2.37,;8.28,-3.14,;6.94,-2.37,;1.21,-.88,;-6.94,-.51,;-6.94,1.03,;-5.61,1.8,;-8.28,1.8,;-9.61,1.03,;-10.95,1.8,;-10.95,3.34,;-9.61,4.11,;-10.38,5.45,;-8.84,5.45,;-8.28,3.34,)| | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The biochemical potency of compounds was determined using a proximity-based assay (ALPHASCREENŽ, Perkin Elmer, Waltham, Mass.) as described previousl... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2GT5RC5 |
More data for this Ligand-Target Pair | |