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Compile Data Set for Download or QSAR

Found 307 hits with Last Name = 'corrette' and Initial = 'cp'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161874
PNG
(CHEMBL3794475)
Show SMILES CCN(CC)c1ccc(C)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C21H27ClN4O/c1-7-26(8-2)16-10-9-13(3)19-20(16)25(5)21(24-19)23-18-14(4)11-15(22)12-17(18)27-6/h9-12H,7-8H2,1-6H3,(H,23,24)
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n/an/a 7.60n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50116105
PNG
(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(-1.91,-13.39,;-3.24,-14.16,;-4.58,-13.4,;-5.91,-14.18,;-7.24,-13.41,;-8.57,-14.19,;-9.91,-13.42,;-5.9,-15.72,;-7.22,-16.49,;-7.23,-18.03,;-8.56,-18.8,;-5.9,-18.8,;-4.55,-18.03,;-3.07,-18.5,;-2.16,-17.24,;-.62,-17.23,;-3.09,-15.99,;-4.56,-16.48,;-2.58,-19.96,;-3.61,-21.11,;-3.13,-22.57,;-1.62,-22.88,;-.59,-21.72,;-1.08,-20.27,;-.06,-19.11,;-1.13,-24.34,;.38,-24.65,;-2.15,-25.5,)|
Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3
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n/an/a 8.5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161832
PNG
(CHEMBL3792517)
Show SMILES CCCN(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C22H28Cl2N4O/c1-6-10-28(11-7-2)17-9-8-16(24)20-21(17)27(4)22(26-20)25-19-14(3)12-15(23)13-18(19)29-5/h8-9,12-13H,6-7,10-11H2,1-5H3,(H,25,26)
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n/an/a 9.5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161862
PNG
(CHEMBL3793568)
Show SMILES Cl.CCN(C(C)C)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C21H27BrN4O.ClH/c1-7-26(13(2)3)17-10-8-9-16-20(17)25(5)21(23-16)24-19-14(4)11-15(22)12-18(19)27-6;/h8-13H,7H2,1-6H3,(H,23,24);1H
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n/an/a 11n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161858
PNG
(CHEMBL3793367)
Show SMILES Cl.CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C22H29BrN4O.ClH/c1-6-11-27(12-7-2)18-10-8-9-17-21(18)26(4)22(24-17)25-20-15(3)13-16(23)14-19(20)28-5;/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,24,25);1H
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536884
PNG
(CHEMBL4581950)
Show SMILES COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(C(C)C)c3ccccc3)c2n1C
Show InChI InChI=1S/C25H27ClN4O/c1-16(2)30(19-10-7-6-8-11-19)21-13-9-12-20-24(21)29(4)25(27-20)28-23-17(3)14-18(26)15-22(23)31-5/h6-16H,1-5H3,(H,27,28)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161868
PNG
(CHEMBL3793070)
Show SMILES CCN(CC)c1ccc(C#N)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C21H24ClN5O/c1-6-27(7-2)16-9-8-14(12-23)19-20(16)26(4)21(25-19)24-18-13(3)10-15(22)11-17(18)28-5/h8-11H,6-7H2,1-5H3,(H,24,25)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161860
PNG
(CHEMBL3793322)
Show SMILES Cl.CCN(CC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C20H25BrN4O.ClH/c1-6-25(7-2)16-10-8-9-15-19(16)24(4)20(22-15)23-18-13(3)11-14(21)12-17(18)26-5;/h8-12H,6-7H2,1-5H3,(H,22,23);1H
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161958
PNG
(CHEMBL3794479)
Show SMILES CCN(CC)c1ccc(OC)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C21H27ClN4O2/c1-7-26(8-2)15-9-10-16(27-5)19-20(15)25(4)21(24-19)23-18-13(3)11-14(22)12-17(18)28-6/h9-12H,7-8H2,1-6H3,(H,23,24)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161841
PNG
(CHEMBL3793985)
Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C22H29ClN4O/c1-6-11-27(12-7-2)18-10-8-9-17-21(18)26(4)22(24-17)25-20-15(3)13-16(23)14-19(20)28-5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,24,25)
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161866
PNG
(CHEMBL3794030)
Show SMILES CCCN(CCC)c1ccc(C#N)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C23H28ClN5O/c1-6-10-29(11-7-2)18-9-8-16(14-25)21-22(18)28(4)23(27-21)26-20-15(3)12-17(24)13-19(20)30-5/h8-9,12-13H,6-7,10-11H2,1-5H3,(H,26,27)
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161861
PNG
(CHEMBL3792935)
Show SMILES Cl.CCCCN(CCCC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C24H33BrN4O.ClH/c1-6-8-13-29(14-9-7-2)20-12-10-11-19-23(20)28(4)24(26-19)27-22-17(3)15-18(25)16-21(22)30-5;/h10-12,15-16H,6-9,13-14H2,1-5H3,(H,26,27);1H
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161854
PNG
(CHEMBL3794051)
Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(C)c12
Show InChI InChI=1S/C23H32N4/c1-7-12-27(13-8-2)20-11-9-10-19-22(20)26(6)23(24-19)25-21-17(4)14-16(3)15-18(21)5/h9-11,14-15H,7-8,12-13H2,1-6H3,(H,24,25)
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n/an/a 15n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161859
PNG
(CHEMBL3792636)
Show SMILES Cl.CCCN(CCC)c1cccc2nc(Nc3c(C)cc(Cl)cc3C(C)C)n(C)c12
Show InChI InChI=1S/C24H33ClN4.ClH/c1-7-12-29(13-8-2)21-11-9-10-20-23(21)28(6)24(26-20)27-22-17(5)14-18(25)15-19(22)16(3)4;/h9-11,14-16H,7-8,12-13H2,1-6H3,(H,26,27);1H
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n/an/a 22n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161867
PNG
(CHEMBL3793277)
Show SMILES CCN(CC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C20H24Cl2N4O/c1-6-26(7-2)15-9-8-14(22)18-19(15)25(4)20(24-18)23-17-12(3)10-13(21)11-16(17)27-5/h8-11H,6-7H2,1-5H3,(H,23,24)
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n/an/a 24n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536887
PNG
(CHEMBL4591335)
Show SMILES COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(C(C)C)c3ccc(Cl)cc3)c2n1C
Show InChI InChI=1S/C25H26Cl2N4O/c1-15(2)31(19-11-9-17(26)10-12-19)21-8-6-7-20-24(21)30(4)25(28-20)29-23-16(3)13-18(27)14-22(23)32-5/h6-15H,1-5H3,(H,28,29)
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n/an/a 25n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536892
PNG
(CHEMBL4544244)
Show SMILES COc1ccc(cn1)N(C(C)C)c1cccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C25H28ClN5O2/c1-15(2)31(18-10-11-22(33-6)27-14-18)20-9-7-8-19-24(20)30(4)25(28-19)29-23-16(3)12-17(26)13-21(23)32-5/h7-15H,1-6H3,(H,28,29)
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n/an/a 25n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536883
PNG
(CHEMBL4593848)
Show SMILES COc1ccc(cc1)N(C(C)C)c1cccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C26H29ClN4O2/c1-16(2)31(19-10-12-20(32-5)13-11-19)22-9-7-8-21-25(22)30(4)26(28-21)29-24-17(3)14-18(27)15-23(24)33-6/h7-16H,1-6H3,(H,28,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536898
PNG
(CHEMBL4540030)
Show SMILES Cl.COCCN(c1ccc(Cl)cc1)c1cccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C25H26Cl2N4O2/c1-16-14-18(27)15-22(33-4)23(16)29-25-28-20-6-5-7-21(24(20)30(25)2)31(12-13-32-3)19-10-8-17(26)9-11-19/h5-11,14-15H,12-13H2,1-4H3,(H,28,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536897
PNG
(CHEMBL4547748)
Show SMILES COc1cccc(c1)N(C(C)C)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C26H29BrN4O2/c1-16(2)31(19-9-7-10-20(15-19)32-5)22-12-8-11-21-25(22)30(4)26(28-21)29-24-17(3)13-18(27)14-23(24)33-6/h7-16H,1-6H3,(H,28,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536891
PNG
(CHEMBL4580457)
Show SMILES CNC(=O)c1cccc(c1)N(C(C)C)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C27H30BrN5O2/c1-16(2)33(20-10-7-9-18(14-20)26(34)29-4)22-12-8-11-21-25(22)32(5)27(30-21)31-24-17(3)13-19(28)15-23(24)35-6/h7-16H,1-6H3,(H,29,34)(H,30,31)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536883
PNG
(CHEMBL4593848)
Show SMILES COc1ccc(cc1)N(C(C)C)c1cccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C26H29ClN4O2/c1-16(2)31(19-10-12-20(32-5)13-11-19)22-9-7-8-21-25(22)30(4)26(28-21)29-24-17(3)14-18(27)15-23(24)33-6/h7-16H,1-6H3,(H,28,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-stimulated adenylate cyclase activity measured after ...

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161863
PNG
(CHEMBL3793560)
Show SMILES COCCN(CCOC)c1cccc2nc(Nc3c(C)cc(Br)cc3OC)n(C)c12
Show InChI InChI=1S/C22H29BrN4O3/c1-15-13-16(23)14-19(30-5)20(15)25-22-24-17-7-6-8-18(21(17)26(22)2)27(9-11-28-3)10-12-29-4/h6-8,13-14H,9-12H2,1-5H3,(H,24,25)
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Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536881
PNG
(CHEMBL4538409)
Show SMILES COc1cc(Br)cc(C)c1Nc1nc2cccc(N(C(C)C)c3cccc(c3)C#N)c2n1C
Show InChI InChI=1S/C26H26BrN5O/c1-16(2)32(20-9-6-8-18(13-20)15-28)22-11-7-10-21-25(22)31(4)26(29-21)30-24-17(3)12-19(27)14-23(24)33-5/h6-14,16H,1-5H3,(H,29,30)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536893
PNG
(CHEMBL4527586)
Show SMILES COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(C(C)C)c3ccc(C)cn3)c2n1C
Show InChI InChI=1S/C25H28ClN5O/c1-15(2)31(22-11-10-16(3)14-27-22)20-9-7-8-19-24(20)30(5)25(28-19)29-23-17(4)12-18(26)13-21(23)32-6/h7-15H,1-6H3,(H,28,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536900
PNG
(CHEMBL4519158)
Show SMILES COc1cc(Br)cc(C)c1Nc1nc2cccc(N(C(C)C)c3cccc(c3)C(=O)N(C)C)c2n1C
Show InChI InChI=1S/C28H32BrN5O2/c1-17(2)34(21-11-8-10-19(15-21)27(35)32(4)5)23-13-9-12-22-26(23)33(6)28(30-22)31-25-18(3)14-20(29)16-24(25)36-7/h8-17H,1-7H3,(H,30,31)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161856
PNG
(CHEMBL3793190)
Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)sc12
Show InChI InChI=1S/C22H29N3S/c1-6-11-25(12-7-2)19-10-8-9-18-21(19)26-22(23-18)24-20-16(4)13-15(3)14-17(20)5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,23,24)
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Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161851
PNG
(CHEMBL3793744)
Show SMILES OC(=O)C(F)(F)F.CCCN(CCC)c1cccc2nc(Nc3ccc(C)cc3C)n(C)c12
Show InChI InChI=1S/C22H30N4.C2HF3O2/c1-6-13-26(14-7-2)20-10-8-9-19-21(20)25(5)22(24-19)23-18-12-11-16(3)15-17(18)4;3-2(4,5)1(6)7/h8-12,15H,6-7,13-14H2,1-5H3,(H,23,24);(H,6,7)
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Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536889
PNG
(CHEMBL4556873)
Show SMILES COc1cc(Br)cc(C)c1Nc1nc2cccc(N(C(C)C)c3ccc(cc3)C#N)c2n1C
Show InChI InChI=1S/C26H26BrN5O/c1-16(2)32(20-11-9-18(15-28)10-12-20)22-8-6-7-21-25(22)31(4)26(29-21)30-24-17(3)13-19(27)14-23(24)33-5/h6-14,16H,1-5H3,(H,29,30)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161832
PNG
(CHEMBL3792517)
Show SMILES CCCN(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C22H28Cl2N4O/c1-6-10-28(11-7-2)17-9-8-16(24)20-21(17)27(4)22(26-20)25-19-14(3)12-15(23)13-18(19)29-5/h8-9,12-13H,6-7,10-11H2,1-5H3,(H,25,26)
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Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-stimulated cAMP accumulation after 4 hrs by steady-gl...

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536899
PNG
(CHEMBL4517763)
Show SMILES COc1cc(Br)cc(C)c1Nc1nc2cccc(N(C(C)C)c3cccc(c3)S(C)(=O)=O)c2n1C
Show InChI InChI=1S/C26H29BrN4O3S/c1-16(2)31(19-9-7-10-20(15-19)35(6,32)33)22-12-8-11-21-25(22)30(4)26(28-21)29-24-17(3)13-18(27)14-23(24)34-5/h7-16H,1-6H3,(H,28,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161853
PNG
(CHEMBL3793781)
Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(C(C)C)c12
Show InChI InChI=1S/C25H36N4/c1-8-13-28(14-9-2)22-12-10-11-21-24(22)29(17(3)4)25(26-21)27-23-19(6)15-18(5)16-20(23)7/h10-12,15-17H,8-9,13-14H2,1-7H3,(H,26,27)
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Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536896
PNG
(CHEMBL4526083)
Show SMILES COc1cc(Br)cc(C)c1Nc1nc2cccc(N(C(C)C)c3cccc(c3)C(C)(C)C(N)=O)c2n1C
Show InChI InChI=1S/C29H34BrN5O2/c1-17(2)35(21-11-8-10-19(15-21)29(4,5)27(31)36)23-13-9-12-22-26(23)34(6)28(32-22)33-25-18(3)14-20(30)16-24(25)37-7/h8-17H,1-7H3,(H2,31,36)(H,32,33)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536890
PNG
(CHEMBL4591720)
Show SMILES COc1cc(Br)cc(C)c1Nc1nc2cccc(N(C(C)C)c3cccc(c3)C(N)=O)c2n1C
Show InChI InChI=1S/C26H28BrN5O2/c1-15(2)32(19-9-6-8-17(13-19)25(28)33)21-11-7-10-20-24(21)31(4)26(29-20)30-23-16(3)12-18(27)14-22(23)34-5/h6-15H,1-5H3,(H2,28,33)(H,29,30)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161844
PNG
(CHEMBL3793329)
Show SMILES OC(=O)C(F)(F)F.CCCN(CCC)c1cccc2nc(Nc3c(C)cccc3C)n(C)c12
Show InChI InChI=1S/C22H30N4.C2HF3O2/c1-6-14-26(15-7-2)19-13-9-12-18-21(19)25(5)22(23-18)24-20-16(3)10-8-11-17(20)4;3-2(4,5)1(6)7/h8-13H,6-7,14-15H2,1-5H3,(H,23,24);(H,6,7)
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Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536886
PNG
(CHEMBL4592625)
Show SMILES Cl.COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(C(C)=O)c3ccc(Cl)cc3)c2n1C
Show InChI InChI=1S/C24H22Cl2N4O2/c1-14-12-17(26)13-21(32-4)22(14)28-24-27-19-6-5-7-20(23(19)29(24)3)30(15(2)31)18-10-8-16(25)9-11-18/h5-13H,1-4H3,(H,27,28)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161864
PNG
(CHEMBL3794050)
Show SMILES CCCN(CCC)c1c(Cl)cc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C22H27Cl3N4O/c1-6-8-29(9-7-2)20-16(25)12-15(24)19-21(20)28(4)22(27-19)26-18-13(3)10-14(23)11-17(18)30-5/h10-12H,6-9H2,1-5H3,(H,26,27)
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Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536885
PNG
(CHEMBL4526475)
Show SMILES COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(CC3CCOC3)c3ccc(Cl)cc3)c2n1C
Show InChI InChI=1S/C27H28Cl2N4O2/c1-17-13-20(29)14-24(34-3)25(17)31-27-30-22-5-4-6-23(26(22)32(27)2)33(15-18-11-12-35-16-18)21-9-7-19(28)8-10-21/h4-10,13-14,18H,11-12,15-16H2,1-3H3,(H,30,31)
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n/an/a 220n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536888
PNG
(CHEMBL4524490)
Show SMILES COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(C(C)C)c3cccc(OC(C)C)c3)c2n1C
Show InChI InChI=1S/C28H33ClN4O2/c1-17(2)33(21-10-8-11-22(16-21)35-18(3)4)24-13-9-12-23-27(24)32(6)28(30-23)31-26-19(5)14-20(29)15-25(26)34-7/h8-18H,1-7H3,(H,30,31)
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n/an/a 580n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161857
PNG
(CHEMBL3793059)
Show SMILES CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)oc12
Show InChI InChI=1S/C22H29N3O/c1-6-11-25(12-7-2)19-10-8-9-18-21(19)26-22(23-18)24-20-16(4)13-15(3)14-17(20)5/h8-10,13-14H,6-7,11-12H2,1-5H3,(H,23,24)
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n/an/a 990n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536895
PNG
(CHEMBL4569860)
Show SMILES COc1cc(Br)cc(C)c1Nc1nc2cccc(N(C(C)C)c3ccc(cc3)S(C)(=O)=O)c2n1C
Show InChI InChI=1S/C26H29BrN4O3S/c1-16(2)31(19-10-12-20(13-11-19)35(6,32)33)22-9-7-8-21-25(22)30(4)26(28-21)29-24-17(3)14-18(27)15-23(24)34-5/h7-16H,1-6H3,(H,28,29)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536894
PNG
(CHEMBL4588387)
Show SMILES COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(C(C)C)c3ccc(OC(C)C)cc3)c2n1C
Show InChI InChI=1S/C28H33ClN4O2/c1-17(2)33(21-11-13-22(14-12-21)35-18(3)4)24-10-8-9-23-27(24)32(6)28(30-23)31-26-19(5)15-20(29)16-25(26)34-7/h8-18H,1-7H3,(H,30,31)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161852
PNG
(CHEMBL3793751)
Show SMILES Cl.CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)n(-c3ccccc3)c12
Show InChI InChI=1S/C28H34N4.ClH/c1-6-16-31(17-7-2)25-15-11-14-24-27(25)32(23-12-9-8-10-13-23)28(29-24)30-26-21(4)18-20(3)19-22(26)5;/h8-15,18-19H,6-7,16-17H2,1-5H3,(H,29,30);1H
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n/an/a 2.20E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161855
PNG
(CHEMBL3793362)
Show SMILES Cl.CCCN(CCC)c1cccc2nc(Nc3c(C)cc(C)cc3C)[nH]c12
Show InChI InChI=1S/C22H30N4.ClH/c1-6-11-26(12-7-2)19-10-8-9-18-21(19)25-22(23-18)24-20-16(4)13-15(3)14-17(20)5;/h8-10,13-14H,6-7,11-12H2,1-5H3,(H2,23,24,25);1H
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n/an/a 2.50E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50536882
PNG
(CHEMBL4566348)
Show SMILES Cl.COc1cc(Cl)cc(C)c1Nc1nc2cccc(N(CC(C)(C)C)c3ccc(Cl)cc3)c2n1C
Show InChI InChI=1S/C27H30Cl2N4O/c1-17-14-19(29)15-23(34-6)24(17)31-26-30-21-8-7-9-22(25(21)32(26)5)33(16-27(2,3)4)20-12-10-18(28)11-13-20/h7-15H,16H2,1-6H3,(H,30,31)
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n/an/a 4.40E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Displacement of ovine [125I-Tyr0]-CRF from human CRF1 receptor expressed in CHO cell membrane measured after 1.5 hrs by TopCount method

Bioorg Med Chem 24: 4675-4691 (2016)


Article DOI: 10.1016/j.bmc.2016.08.005
BindingDB Entry DOI: 10.7270/Q2G164BQ
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161925
PNG
(CHEMBL3793159)
Show SMILES CCN(CC)c1ccc(-c2ccccc2)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C26H29ClN4O/c1-6-31(7-2)21-14-13-20(18-11-9-8-10-12-18)24-25(21)30(4)26(29-24)28-23-17(3)15-19(27)16-22(23)32-5/h8-16H,6-7H2,1-5H3,(H,28,29)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50161865
PNG
(CHEMBL3793845)
Show SMILES CCCN(CCC)c1c(Cl)ccc2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C22H28Cl2N4O/c1-6-10-28(11-7-2)20-16(24)8-9-17-21(20)27(4)22(25-17)26-19-14(3)12-15(23)13-18(19)29-5/h8-9,12-13H,6-7,10-11H2,1-5H3,(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method

J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM228392
PNG
(6-Cyano-7-(4-(4-chlorophenylcarbamoyl)phenoxy)chro...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3)c(cc12)C#N
Show InChI InChI=1S/C26H21ClN2O5/c27-19-5-1-16(2-6-19)9-11-29-25(30)17-3-7-20(8-4-17)34-23-14-24-22(13-18(23)15-28)21(26(31)32)10-12-33-24/h1-8,13-14,21H,9-12H2,(H,29,30)(H,31,32)
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US Patent
n/an/an/an/a 400n/an/a7.425



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...

US Patent US9556139 (2017)


BindingDB Entry DOI: 10.7270/Q2S75J9Q
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM228392
PNG
(6-Cyano-7-(4-(4-chlorophenylcarbamoyl)phenoxy)chro...)
Show SMILES OC(=O)C1CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3)c(cc12)C#N
Show InChI InChI=1S/C26H21ClN2O5/c27-19-5-1-16(2-6-19)9-11-29-25(30)17-3-7-20(8-4-17)34-23-14-24-22(13-18(23)15-28)21(26(31)32)10-12-33-24/h1-8,13-14,21H,9-12H2,(H,29,30)(H,31,32)
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n/an/an/an/a 16.6n/an/a7.425



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...

US Patent US9556139 (2017)


BindingDB Entry DOI: 10.7270/Q2S75J9Q
More data for this
Ligand-Target Pair
Prostaglandin D2 receptor 2


(Homo sapiens (Human))		BDBM228398
PNG
(4-(6-Cyano-4-(methoxycarbonyl)chroman-7-yloxy)benz...)
Show SMILES CC1(CCOc2cc(Oc3ccc(cc3)C(=O)NCCc3ccc(Cl)cc3)c(cc12)C#N)C(O)=O
Show InChI InChI=1S/C27H23ClN2O5/c1-27(26(32)33)11-13-34-24-15-23(19(16-29)14-22(24)27)35-21-8-4-18(5-9-21)25(31)30-12-10-17-2-6-20(28)7-3-17/h2-9,14-15H,10-13H2,1H3,(H,30,31)(H,32,33)
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n/an/an/an/a 70n/an/a7.425



Array BioPharma Inc.

US Patent


Assay Description
The coding sequence of human DP2 was introduced into the human Leukemic cell line K562 by electroporation and stable clones expressing DP2 were obtai...

US Patent US9556139 (2017)


BindingDB Entry DOI: 10.7270/Q2S75J9Q
More data for this
Ligand-Target Pair
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