Compile Data Set for Download or QSAR

Found 730 hits with Last Name = 'curtis' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174619 (CHEMBL197747 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3ccc(cn3)[N+]([O-])=O)ccc2o1 Show InChI InChI=1S/C20H22N4O3/c1-14-3-2-9-23(14)10-8-18-12-15-11-16(4-6-19(15)27-18)22-20-7-5-17(13-21-20)24(25)26/h4-7,11-14H,2-3,8-10H2,1H3,(H,21,22)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.0500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) Show SMILES Clc1ccc(cn1)C1CC2CCC1N2 |TLB:4:7:11.10:13| Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in human K177 cell membrane incubated for 75 mins by liquid scintillation spectro...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115820 BindingDB Entry DOI: 10.7270/Q2WW7N96
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) Show SMILES Clc1ccc(cn1)C1CC2CCC1N2 |TLB:4:7:11.10:13| Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]cytisine from human alpha4beta2 nAChR expressed in human K177 cell membrane incubated for 75 mins by liquid scintillation spectro...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115820 BindingDB Entry DOI: 10.7270/Q2WW7N96
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50074627 (4-[2-(5,5-Dimethyl-hex-1-ynyl)-cyclopropyl]-1H-imi...) Show SMILES CC(C)(C)CCC#CC1CC1c1cnc[nH]1 Show InChI InChI=1S/C14H20N2/c1-14(2,3)7-5-4-6-11-8-12(11)13-9-15-10-16-13/h9-12H,5,7-8H2,1-3H3,(H,15,16)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.0800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158590 (1-(3-{2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-b...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)-c1cccc(c1)C(C)=O Show InChI InChI=1S/C23H25NO2/c1-16-5-4-11-24(16)12-10-22-15-21-14-20(8-9-23(21)26-22)19-7-3-6-18(13-19)17(2)25/h3,6-9,13-16H,4-5,10-12H2,1-2H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.0800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174627 (CHEMBL199245 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3cncnc3)ccc2o1 Show InChI InChI=1S/C19H22N4O/c1-14-3-2-7-23(14)8-6-18-10-15-9-16(4-5-19(15)24-18)22-17-11-20-13-21-12-17/h4-5,9-14,22H,2-3,6-8H2,1H3/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.0800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158588 ((3,5-Difluoro-phenyl)-{2-[2-((R)-2-methyl-pyrrolid...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)C(=O)c1cc(F)cc(F)c1 Show InChI InChI=1S/C22H21F2NO2/c1-14-3-2-7-25(14)8-6-20-12-16-9-15(4-5-21(16)27-20)22(26)17-10-18(23)13-19(24)11-17/h4-5,9-14H,2-3,6-8H2,1H3/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.0900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158596 ((3-Fluoro-phenyl)-{2-[2-((R)-2-methyl-pyrrolidin-1...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)C(=O)c1cccc(F)c1 Show InChI InChI=1S/C22H22FNO2/c1-15-4-3-10-24(15)11-9-20-14-18-12-17(7-8-21(18)26-20)22(25)16-5-2-6-19(23)13-16/h2,5-8,12-15H,3-4,9-11H2,1H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356873 (CHEMBL1914541) Show SMILES CN1CCN(CC1)c1nc(N)nc2c3cc(Cl)ccc3oc12 Show InChI InChI=1S/C15H16ClN5O/c1-20-4-6-21(7-5-20)14-13-12(18-15(17)19-14)10-8-9(16)2-3-11(10)22-13/h2-3,8H,4-7H2,1H3,(H2,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [3H]histamine from recombinant human histamine H4 receptor				Bioorg Med Chem Lett 21: 6577-81 (2011) Article DOI: 10.1016/j.bmcl.2011.08.014 BindingDB Entry DOI: 10.7270/Q2CN749X
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174621 (CHEMBL196467 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3cnccn3)ccc2o1 Show InChI InChI=1S/C19H22N4O/c1-14-3-2-9-23(14)10-6-17-12-15-11-16(4-5-18(15)24-17)22-19-13-20-7-8-21-19/h4-5,7-8,11-14H,2-3,6,9-10H2,1H3,(H,21,22)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50174619 (CHEMBL197747 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3ccc(cn3)[N+]([O-])=O)ccc2o1 Show InChI InChI=1S/C20H22N4O3/c1-14-3-2-9-23(14)10-8-18-12-15-11-16(4-6-19(15)27-18)22-20-7-5-17(13-21-20)24(25)26/h4-7,11-14H,2-3,8-10H2,1H3,(H,21,22)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174613 (4-({2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-ben...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(CNc3cc(nc(c3)C#N)C#N)ccc2o1 Show InChI InChI=1S/C23H23N5O/c1-16-3-2-7-28(16)8-6-22-10-18-9-17(4-5-23(18)29-22)15-26-19-11-20(13-24)27-21(12-19)14-25/h4-5,9-12,16H,2-3,6-8,15H2,1H3,(H,26,27)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174637 (CHEMBL196294 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3ncccc3[N+]([O-])=O)ccc2o1 Show InChI InChI=1S/C20H22N4O3/c1-14-4-3-10-23(14)11-8-17-13-15-12-16(6-7-19(15)27-17)22-20-18(24(25)26)5-2-9-21-20/h2,5-7,9,12-14H,3-4,8,10-11H2,1H3,(H,21,22)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174615 (CHEMBL424842 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(CNc3ncc(s3)[N+]([O-])=O)ccc2o1 Show InChI InChI=1S/C19H22N4O3S/c1-13-3-2-7-22(13)8-6-16-10-15-9-14(4-5-17(15)26-16)11-20-19-21-12-18(27-19)23(24)25/h4-5,9-10,12-13H,2-3,6-8,11H2,1H3,(H,20,21)/t13-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158609 ((4-Chloro-phenyl)-{2-[2-((R)-2-methyl-pyrrolidin-1...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)C(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H22ClNO2/c1-15-3-2-11-24(15)12-10-20-14-18-13-17(6-9-21(18)26-20)22(25)16-4-7-19(23)8-5-16/h4-9,13-15H,2-3,10-12H2,1H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158607 ((3-Chloro-phenyl)-{2-[2-((R)-2-methyl-pyrrolidin-1...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)C(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C22H22ClNO2/c1-15-4-3-10-24(15)11-9-20-14-18-12-17(7-8-21(18)26-20)22(25)16-5-2-6-19(23)13-16/h2,5-8,12-15H,3-4,9-11H2,1H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158599 (CHEMBL369502 | Cyclopropyl-(3-{2-[2-((R)-2-methyl-...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)-c1cccc(c1)C(=O)C1CC1 Show InChI InChI=1S/C25H27NO2/c1-17-4-3-12-26(17)13-11-23-16-22-15-20(9-10-24(22)28-23)19-5-2-6-21(14-19)25(27)18-7-8-18/h2,5-6,9-10,14-18H,3-4,7-8,11-13H2,1H3/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158603 ((4-Fluoro-3-methyl-phenyl)-{2-[2-((R)-2-methyl-pyr...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)C(=O)c1ccc(F)c(C)c1 Show InChI InChI=1S/C23H24FNO2/c1-15-12-17(5-7-21(15)24)23(26)18-6-8-22-19(13-18)14-20(27-22)9-11-25-10-3-4-16(25)2/h5-8,12-14,16H,3-4,9-11H2,1-2H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158592 (CHEMBL368699 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)C(=O)c1ccc(C)cc1 Show InChI InChI=1S/C23H25NO2/c1-16-5-7-18(8-6-16)23(25)19-9-10-22-20(14-19)15-21(26-22)11-13-24-12-3-4-17(24)2/h5-10,14-15,17H,3-4,11-13H2,1-2H3/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174620 (CHEMBL371258 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3ccccc3[N+]([O-])=O)ccc2o1 Show InChI InChI=1S/C21H23N3O3/c1-15-5-4-11-23(15)12-10-18-14-16-13-17(8-9-21(16)27-18)22-19-6-2-3-7-20(19)24(25)26/h2-3,6-9,13-15,22H,4-5,10-12H2,1H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158605 (CHEMBL362662 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)C(=O)c1ccccc1 Show InChI InChI=1S/C22H23NO2/c1-16-6-5-12-23(16)13-11-20-15-19-14-18(9-10-21(19)25-20)22(24)17-7-3-2-4-8-17/h2-4,7-10,14-16H,5-6,11-13H2,1H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Homo sapiens (Human))	BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) Show SMILES Clc1ccc(cn1)C1CC2CCC1N2 |TLB:4:7:11.10:13| Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human alpha3beta4 nAChR				Citation and Details Article DOI: 10.1016/j.bmc.2020.115820 BindingDB Entry DOI: 10.7270/Q2WW7N96
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158593 (1-(3-{2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-b...) Show SMILES CCC(=O)c1cccc(c1)-c1ccc2oc(CCN3CCC[C@H]3C)cc2c1 Show InChI InChI=1S/C24H27NO2/c1-3-23(26)20-8-4-7-18(14-20)19-9-10-24-21(15-19)16-22(27-24)11-13-25-12-5-6-17(25)2/h4,7-10,14-17H,3,5-6,11-13H2,1-2H3/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158604 (1-(3-{2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-b...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)-c1cccc(c1)C(C)(C)O Show InChI InChI=1S/C24H29NO2/c1-17-6-5-12-25(17)13-11-22-16-20-14-19(9-10-23(20)27-22)18-7-4-8-21(15-18)24(2,3)26/h4,7-10,14-17,26H,5-6,11-13H2,1-3H3/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158598 (CHEMBL178950 | Cyclopropyl-(4-{2-[2-((R)-2-methyl-...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)-c1ccc(cc1)C(=O)C1CC1 Show InChI InChI=1S/C25H27NO2/c1-17-3-2-13-26(17)14-12-23-16-22-15-21(10-11-24(22)28-23)18-4-6-19(7-5-18)25(27)20-8-9-20/h4-7,10-11,15-17,20H,2-3,8-9,12-14H2,1H3/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158602 (3-{2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-benz...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)-c1cccc(c1)C#N Show InChI InChI=1S/C22H22N2O/c1-16-4-3-10-24(16)11-9-21-14-20-13-19(7-8-22(20)25-21)18-6-2-5-17(12-18)15-23/h2,5-8,12-14,16H,3-4,9-11H2,1H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50174627 (CHEMBL199245 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3cncnc3)ccc2o1 Show InChI InChI=1S/C19H22N4O/c1-14-3-2-7-23(14)8-6-18-10-15-9-16(4-5-19(15)24-18)22-17-11-20-13-21-12-17/h4-5,9-14,22H,2-3,6-8H2,1H3/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174614 (4-{2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-benz...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3ccc(cc3)C#N)ccc2o1 Show InChI InChI=1S/C22H23N3O/c1-16-3-2-11-25(16)12-10-21-14-18-13-20(8-9-22(18)26-21)24-19-6-4-17(15-23)5-7-19/h4-9,13-14,16,24H,2-3,10-12H2,1H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158610 ((4-Fluoro-phenyl)-{2-[2-((R)-2-methyl-pyrrolidin-1...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)C(=O)c1ccc(F)cc1 Show InChI InChI=1S/C22H22FNO2/c1-15-3-2-11-24(15)12-10-20-14-18-13-17(6-9-21(18)26-20)22(25)16-4-7-19(23)8-5-16/h4-9,13-15H,2-3,10-12H2,1H3/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50143282 ((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...) Show SMILES O=c1cccc2[C@H]3CNC[C@H](C3)Cn12 Show InChI InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8?,9-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]cytisine from human alpha4beta2 nAChR by Cheng-Prusoff equation analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115820 BindingDB Entry DOI: 10.7270/Q2WW7N96
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174624 (CHEMBL371210 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(CNc3cnccn3)ccc2o1 Show InChI InChI=1S/C20H24N4O/c1-15-3-2-9-24(15)10-6-18-12-17-11-16(4-5-19(17)25-18)13-23-20-14-21-7-8-22-20/h4-5,7-8,11-12,14-15H,2-3,6,9-10,13H2,1H3,(H,22,23)/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174634 (3-{2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-benz...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3cccc(c3)C#N)ccc2o1 Show InChI InChI=1S/C22H23N3O/c1-16-4-3-10-25(16)11-9-21-14-18-13-20(7-8-22(18)26-21)24-19-6-2-5-17(12-19)15-23/h2,5-8,12-14,16,24H,3-4,9-11H2,1H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50356794 (CHEMBL1914462) Show SMILES CN1CCN(CC1)c1nc(N)nc2c3cc(Cl)ccc3sc12 Show InChI InChI=1S/C15H16ClN5S/c1-20-4-6-21(7-5-20)14-13-12(18-15(17)19-14)10-8-9(16)2-3-11(10)22-13/h2-3,8H,4-7H2,1H3,(H2,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [3H]histamine from recombinant human histamine H4 receptor				Bioorg Med Chem Lett 21: 6577-81 (2011) Article DOI: 10.1016/j.bmcl.2011.08.014 BindingDB Entry DOI: 10.7270/Q2CN749X
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174631 (CHEMBL196629 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(CNc3ccc(cn3)[N+]([O-])=O)ccc2o1 Show InChI InChI=1S/C21H24N4O3/c1-15-3-2-9-24(15)10-8-19-12-17-11-16(4-6-20(17)28-19)13-22-21-7-5-18(14-23-21)25(26)27/h4-7,11-12,14-15H,2-3,8-10,13H2,1H3,(H,22,23)/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174636 (CHEMBL198703 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3ncccn3)ccc2o1 Show InChI InChI=1S/C19H22N4O/c1-14-4-2-10-23(14)11-7-17-13-15-12-16(5-6-18(15)24-17)22-19-20-8-3-9-21-19/h3,5-6,8-9,12-14H,2,4,7,10-11H2,1H3,(H,20,21,22)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174629 (CHEMBL194620 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(CNc3ccccc3[N+]([O-])=O)ccc2o1 Show InChI InChI=1S/C22H25N3O3/c1-16-5-4-11-24(16)12-10-19-14-18-13-17(8-9-22(18)28-19)15-23-20-6-2-3-7-21(20)25(26)27/h2-3,6-9,13-14,16,23H,4-5,10-12,15H2,1H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174623 ((6-Chloro-pyridazin-3-yl)-{2-[2-((R)-2-methyl-pyrr...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(CNc3ccc(Cl)nn3)ccc2o1 Show InChI InChI=1S/C20H23ClN4O/c1-14-3-2-9-25(14)10-8-17-12-16-11-15(4-5-18(16)26-17)13-22-20-7-6-19(21)23-24-20/h4-7,11-12,14H,2-3,8-10,13H2,1H3,(H,22,24)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50548705 (CHEMBL4740159) Show SMILES C[C@@H]1CC2C3Cn4c(cccc4=O)C(CN2C)C13 |r,TLB:0:1:4:13.15.14,16:15:2.1:4,THB:1:17:5.6.7:3.15.14,5:4:2.1:13.15.14,7:13:2.1:4| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]cytisine from human alpha4beta2 nAChR by Cheng-Prusoff equation analysis				Citation and Details Article DOI: 10.1016/j.bmc.2020.115820 BindingDB Entry DOI: 10.7270/Q2WW7N96
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174625 ((5-Ethyl-pyrimidin-2-yl)-{2-[2-((R)-2-methyl-pyrro...) Show SMILES CCc1cnc(NCc2ccc3oc(CCN4CCC[C@H]4C)cc3c2)nc1 Show InChI InChI=1S/C22H28N4O/c1-3-17-13-23-22(24-14-17)25-15-18-6-7-21-19(11-18)12-20(27-21)8-10-26-9-4-5-16(26)2/h6-7,11-14,16H,3-5,8-10,15H2,1-2H3,(H,23,24,25)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174639 (6-({2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-ben...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(CNc3ccc(cn3)C#N)ccc2o1 Show InChI InChI=1S/C22H24N4O/c1-16-3-2-9-26(16)10-8-20-12-19-11-17(4-6-21(19)27-20)14-24-22-7-5-18(13-23)15-25-22/h4-7,11-12,15-16H,2-3,8-10,14H2,1H3,(H,24,25)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50174637 (CHEMBL196294 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3ncccc3[N+]([O-])=O)ccc2o1 Show InChI InChI=1S/C20H22N4O3/c1-14-4-3-10-23(14)11-8-17-13-15-12-16(6-7-19(15)27-17)22-20-18(24(25)26)5-2-9-21-20/h2,5-7,9,12-14H,3-4,8,10-11H2,1H3,(H,21,22)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158608 ((4-Chloro-3-methyl-phenyl)-{2-[2-((R)-2-methyl-pyr...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)C(=O)c1ccc(Cl)c(C)c1 Show InChI InChI=1S/C23H24ClNO2/c1-15-12-17(5-7-21(15)24)23(26)18-6-8-22-19(13-18)14-20(27-22)9-11-25-10-3-4-16(25)2/h5-8,12-14,16H,3-4,9-11H2,1-2H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.350	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50174621 (CHEMBL196467 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(Nc3cnccn3)ccc2o1 Show InChI InChI=1S/C19H22N4O/c1-14-3-2-9-23(14)10-6-17-12-15-11-16(4-5-18(15)24-17)22-19-13-20-7-8-21-19/h4-5,7-8,11-14H,2-3,6,9-10H2,1H3,(H,21,22)/t14-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50174613 (4-({2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-ben...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(CNc3cc(nc(c3)C#N)C#N)ccc2o1 Show InChI InChI=1S/C23H23N5O/c1-16-3-2-7-28(16)8-6-22-10-18-9-17(4-5-23(18)29-22)15-26-19-11-20(13-24)27-21(12-19)14-25/h4-5,9-12,16H,2-3,6-8,15H2,1H3,(H,26,27)/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for rat histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50143282 ((-)-cytisine | (1R,5S)-1,2,3,4,5,6-Hexahydro-1,5-m...) Show SMILES O=c1cccc2[C@H]3CNC[C@H](C3)Cn12 Show InChI InChI=1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8?,9-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H]nicotine from rat alpha4beta2 nAChR by liquid scintillation counting				Citation and Details Article DOI: 10.1016/j.bmc.2020.115820 BindingDB Entry DOI: 10.7270/Q2WW7N96
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM50315348 ((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...) Show SMILES CN[C@@H]1CCN(C1)c1nc(N)nc2c3cc(Cl)ccc3oc12 |r| Show InChI InChI=1S/C15H16ClN5O/c1-18-9-4-5-21(7-9)14-13-12(19-15(17)20-14)10-6-8(16)2-3-11(10)22-13/h2-3,6,9,18H,4-5,7H2,1H3,(H2,17,19,20)/t9-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development Curated by ChEMBL					Assay Description Displacement of [3H]histamine from recombinant human histamine H4 receptor				Bioorg Med Chem Lett 21: 6577-81 (2011) Article DOI: 10.1016/j.bmcl.2011.08.014 BindingDB Entry DOI: 10.7270/Q2CN749X
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174612 (3-({2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-ben...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(CNc3cccc(c3)C#N)ccc2o1 Show InChI InChI=1S/C23H25N3O/c1-17-4-3-10-26(17)11-9-22-14-20-12-19(7-8-23(20)27-22)16-25-21-6-2-5-18(13-21)15-24/h2,5-8,12-14,17,25H,3-4,9-11,16H2,1H3/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50158590 (1-(3-{2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-b...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(ccc2o1)-c1cccc(c1)C(C)=O Show InChI InChI=1S/C23H25NO2/c1-16-5-4-11-24(16)12-10-22-15-21-14-20(8-9-23(21)26-22)19-7-3-6-18(13-19)17(2)25/h3,6-9,13-16H,4-5,10-12H2,1-2H3/t16-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50174640 (CHEMBL199187 | {2-[2-((R)-2-Methyl-pyrrolidin-1-yl...) Show SMILES C[C@@H]1CCCN1CCc1cc2cc(CNc3ncccc3[N+]([O-])=O)ccc2o1 Show InChI InChI=1S/C21H24N4O3/c1-15-4-3-10-24(15)11-8-18-13-17-12-16(6-7-20(17)28-18)14-23-21-19(25(26)27)5-2-9-22-21/h2,5-7,9,12-13,15H,3-4,8,10-11,14H2,1H3,(H,22,23)/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity for human histamine H3 receptor using [3H]-N-alpha-methylhistamine				J Med Chem 48: 6482-90 (2005) Article DOI: 10.1021/jm0504398 BindingDB Entry DOI: 10.7270/Q25D8RDT
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50158606 (1-(3-{2-[2-((R)-2-Methyl-pyrrolidin-1-yl)-ethyl]-b...) Show SMILES CC(O)c1cccc(c1)-c1ccc2oc(CCN3CCC[C@H]3C)cc2c1 Show InChI InChI=1S/C23H27NO2/c1-16-5-4-11-24(16)12-10-22-15-21-14-20(8-9-23(21)26-22)19-7-3-6-18(13-19)17(2)25/h3,6-9,13-17,25H,4-5,10-12H2,1-2H3/t16-,17?/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.440	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptor				J Med Chem 48: 38-55 (2005) Article DOI: 10.1021/jm040118g BindingDB Entry DOI: 10.7270/Q2571CST
					More data for this Ligand-Target Pair

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