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Compile Data Set for Download or QSAR

Found 6 hits with Last Name = 'darrow' and Initial = 'al'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelial lipase


(Homo sapiens (Human))
BDBM50433473
PNG
(CHEMBL2381070)
Show SMILES Fc1cc(F)cc(OCCCCCNC(=O)SCc2nnc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C21H21F2N3O3S/c22-16-11-17(23)13-18(12-16)28-10-6-2-5-9-24-21(27)30-14-19-25-26-20(29-19)15-7-3-1-4-8-15/h1,3-4,7-8,11-13H,2,5-6,9-10,14H2,(H,24,27)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Janssen Research and Development, LLC

Curated by ChEMBL


Assay Description
Time dependent inhibition of human EL (19 to 500) expressed in HEK293 cells using PED-A1 as substrate by spectrophotometry


Bioorg Med Chem Lett 23: 2595-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.113
BindingDB Entry DOI: 10.7270/Q24T6KQV
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM50433475
PNG
(CHEMBL2381067)
Show SMILES Fc1ccccc1OC(=O)NCCCCCCc1ccccc1
Show InChI InChI=1S/C19H22FNO2/c20-17-13-7-8-14-18(17)23-19(22)21-15-9-2-1-4-10-16-11-5-3-6-12-16/h3,5-8,11-14H,1-2,4,9-10,15H2,(H,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 470n/an/an/an/an/an/a



Janssen Research and Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of mouse EL expressed in HEK293 cells using PED-A1 as substrate by spectrophotometry


Bioorg Med Chem Lett 23: 2595-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.113
BindingDB Entry DOI: 10.7270/Q24T6KQV
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM50433472
PNG
(CHEMBL2381069)
Show SMILES Fc1ccccc1CSC(=O)NCCCCCCc1ccccc1
Show InChI InChI=1S/C20H24FNOS/c21-19-14-8-7-13-18(19)16-24-20(23)22-15-9-2-1-4-10-17-11-5-3-6-12-17/h3,5-8,11-14H,1-2,4,9-10,15-16H2,(H,22,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 680n/an/an/an/an/an/a



Janssen Research and Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of mouse EL expressed in HEK293 cells using PED-A1 as substrate by spectrophotometry


Bioorg Med Chem Lett 23: 2595-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.113
BindingDB Entry DOI: 10.7270/Q24T6KQV
More data for this
Ligand-Target Pair
Hepatic triacylglycerol lipase


(Homo sapiens (Human))
BDBM50433472
PNG
(CHEMBL2381069)
Show SMILES Fc1ccccc1CSC(=O)NCCCCCCc1ccccc1
Show InChI InChI=1S/C20H24FNOS/c21-19-14-8-7-13-18(19)16-24-20(23)22-15-9-2-1-4-10-17-11-5-3-6-12-17/h3,5-8,11-14H,1-2,4,9-10,15-16H2,(H,22,23)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.36E+3n/an/an/an/an/an/a



Janssen Research and Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of human HL expressed in HEK293 cells using PED-A1 as substrate by spectrophotometry


Bioorg Med Chem Lett 23: 2595-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.113
BindingDB Entry DOI: 10.7270/Q24T6KQV
More data for this
Ligand-Target Pair
Lipoprotein lipase


(Homo sapiens (Human))
BDBM50433472
PNG
(CHEMBL2381069)
Show SMILES Fc1ccccc1CSC(=O)NCCCCCCc1ccccc1
Show InChI InChI=1S/C20H24FNOS/c21-19-14-8-7-13-18(19)16-24-20(23)22-15-9-2-1-4-10-17-11-5-3-6-12-17/h3,5-8,11-14H,1-2,4,9-10,15-16H2,(H,22,23)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.69E+3n/an/an/an/an/an/a



Janssen Research and Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of human LPL expressed in HEK293 cells using PED-A1 as substrate by spectrophotometry


Bioorg Med Chem Lett 23: 2595-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.113
BindingDB Entry DOI: 10.7270/Q24T6KQV
More data for this
Ligand-Target Pair
Endothelial lipase


(Mus musculus (Mouse))
BDBM50433474
PNG
(CHEMBL2381068)
Show SMILES Fc1ccccc1COC(=O)NCCCCCCc1ccccc1
Show InChI InChI=1S/C20H24FNO2/c21-19-14-8-7-13-18(19)16-24-20(23)22-15-9-2-1-4-10-17-11-5-3-6-12-17/h3,5-8,11-14H,1-2,4,9-10,15-16H2,(H,22,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.30E+4n/an/an/an/an/an/a



Janssen Research and Development, LLC

Curated by ChEMBL


Assay Description
Inhibition of mouse EL expressed in HEK293 cells using PED-A1 as substrate by spectrophotometry


Bioorg Med Chem Lett 23: 2595-7 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.113
BindingDB Entry DOI: 10.7270/Q24T6KQV
More data for this
Ligand-Target Pair