Compile Data Set for Download or QSAR

Found 323 hits with Last Name = 'diab' and Initial = 's'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50563323 (CHEMBL4791586) Show SMILES Clc1cncc(-c2cc3ccccc3s2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSKbeta H350L mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of [...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50277622 (CHEMBL4162390) Show SMILES COc1ccc(Nc2nccc(n2)-c2sc(nc2C)N(C)C)c(OC)c1 Show InChI InChI=1S/C18H21N5O2S/c1-11-16(26-18(20-11)23(2)3)14-8-9-19-17(22-14)21-13-7-6-12(24-4)10-15(13)25-5/h6-10H,1-5H3,(H,19,21,22)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50277601 (CHEMBL4167646) Show SMILES COc1ccc(Nc2nccc(n2)-c2sc(SCCN(C)C)nc2C)c(OC)c1 Show InChI InChI=1S/C20H25N5O2S2/c1-13-18(29-20(22-13)28-11-10-25(2)3)16-8-9-21-19(24-16)23-15-7-6-14(26-4)12-17(15)27-5/h6-9,12H,10-11H2,1-5H3,(H,21,23,24)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50073190 (CHEMBL3408213 | US11471446, Compound DBA-11) Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc(Cl)c1N1CCC2(CCNC2=O)CC1 Show InChI InChI=1S/C23H24ClN5O/c1-28-15-18(12-27-28)16-2-4-17(5-3-16)19-13-25-14-20(24)21(19)29-10-7-23(8-11-29)6-9-26-22(23)30/h2-5,12-15H,6-11H2,1H3,(H,26,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM50563322 (CHEMBL4777349) Show SMILES Clc1cncc(-c2cc3ccccc3o2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSKalpha S449A mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of ...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563322 (CHEMBL4777349) Show SMILES Clc1cncc(-c2cc3ccccc3o2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563321 (CHEMBL4744174) Show SMILES Clc1cncc(-c2c[nH]c3ncccc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563313 (CHEMBL4778713) Show SMILES Clc1cncc(-c2cccc3c4ccccc4oc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563310 (CHEMBL4790136) Show SMILES Clc1cncc(-c2cccc3ccccc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130704 (CHEMBL3632744) Show SMILES CNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C Show InChI InChI=1S/C18H19FN4O2S/c1-9(2)25-13-7-11(19)5-6-12(13)23-16-14-10(3)15(17(24)20-4)26-18(14)22-8-21-16/h5-9H,1-4H3,(H,20,24)(H,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130705 (CHEMBL3632745) Show SMILES CCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C Show InChI InChI=1S/C19H21FN4O2S/c1-5-21-18(25)16-11(4)15-17(22-9-23-19(15)27-16)24-13-7-6-12(20)8-14(13)26-10(2)3/h6-10H,5H2,1-4H3,(H,21,25)(H,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50563322 (CHEMBL4777349) Show SMILES Clc1cncc(-c2cc3ccccc3o2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	18	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSKbeta H350L mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of [...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563303 (CHEMBL4788598) Show SMILES Clc1cncc(-c2cccc3[nH]ccc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563325 (CHEMBL4743413) Show SMILES Clc1cncc(-c2csc3ccccc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	21	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563311 (CHEMBL4757811) Show SMILES Cc1ccc(-c2cncc(Cl)c2N2CCC3(CCNC3=O)CC2)c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563306 (CHEMBL4798011) Show SMILES Clc1cncc(-c2cccc3ncccc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563314 (CHEMBL4783542) Show SMILES Clc1cncc(-c2cccc3c4ccccc4sc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563312 (CHEMBL4780807) Show SMILES COc1ccc(-c2cncc(Cl)c2N2CCC3(CCNC3=O)CC2)c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50277603 (CHEMBL4167329) Show SMILES COc1ccc(Nc2nccc(n2)-c2sc(SCCCN(C)C)nc2C)c(OC)c1 Show InChI InChI=1S/C21H27N5O2S2/c1-14-19(30-21(23-14)29-12-6-11-26(2)3)17-9-10-22-20(25-17)24-16-8-7-15(27-4)13-18(16)28-5/h7-10,13H,6,11-12H2,1-5H3,(H,22,24,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130706 (CHEMBL3632746) Show SMILES COCCNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C Show InChI InChI=1S/C20H23FN4O3S/c1-11(2)28-15-9-13(21)5-6-14(15)25-18-16-12(3)17(19(26)22-7-8-27-4)29-20(16)24-10-23-18/h5-6,9-11H,7-8H2,1-4H3,(H,22,26)(H,23,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50277602 (CHEMBL4164283) Show SMILES CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(OC)cc2OC)n1 Show InChI InChI=1S/C17H19N5O2S/c1-10-15(25-17(18-2)20-10)13-7-8-19-16(22-13)21-12-6-5-11(23-3)9-14(12)24-4/h5-9H,1-4H3,(H,18,20)(H,19,21,22)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563296 (CHEMBL4745572) Show SMILES Clc1cncc(-c2cnn(c2)-c2ccccc2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM50563323 (CHEMBL4791586) Show SMILES Clc1cncc(-c2cc3ccccc3s2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	43	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human GSKalpha S449A mutant (2 to 3nd residues) using YRRAAVPPSPSLSRHSSPHQS(p) EDEEE as substrate incubated for 40 mins in presence of ...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563323 (CHEMBL4791586) Show SMILES Clc1cncc(-c2cc3ccccc3s2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	48	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563320 (CHEMBL4778461) Show SMILES Clc1cncc(-c2cn(c3ncccc23)S(=O)(=O)c2ccccc2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563302 (CHEMBL4800651) Show SMILES Cn1cc2c(cccc2n1)-c1cncc(Cl)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563307 (CHEMBL4743572) Show SMILES Clc1cncc(-c2cccc3cnccc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	52	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563319 (CHEMBL4800101) Show SMILES Clc1cncc(-c2c[nH]c3ccccc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563317 (CHEMBL4758431) Show SMILES Clc1cncc(-c2cn(Cc3ccccc3)c3ccccc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	58	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50277648 (CHEMBL4159419) Show SMILES COc1ccc(Nc2nccc(n2)-c2sc(SCc3cccnc3)nc2C)c(OC)c1 Show InChI InChI=1S/C22H21N5O2S2/c1-14-20(31-22(25-14)30-13-15-5-4-9-23-12-15)18-8-10-24-21(27-18)26-17-7-6-16(28-2)11-19(17)29-3/h4-12H,13H2,1-3H3,(H,24,26,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Binding affinity determined against ETA receptor in porcine aortic smooth muscle membrane				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM50073190 (CHEMBL3408213 | US11471446, Compound DBA-11) Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc(Cl)c1N1CCC2(CCNC2=O)CC1 Show InChI InChI=1S/C23H24ClN5O/c1-28-15-18(12-27-28)16-2-4-17(5-3-16)19-13-25-14-20(24)21(19)29-10-7-23(8-11-29)6-9-26-22(23)30/h2-5,12-15H,6-11H2,1H3,(H,26,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	61	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human full length PKCtheta using histone H1 as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50277618 (CHEMBL4165526) Show SMILES Oc1ccccc1Nc1nccc(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C18H14N4O/c23-17-8-4-3-7-16(17)22-18-19-10-9-15(21-18)13-11-20-14-6-2-1-5-12(13)14/h1-11,20,23H,(H,19,21,22)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	63	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50277604 (CHEMBL4159742) Show SMILES COCCSc1nc(C)c(s1)-c1ccnc(Nc2ccc(OC)cc2OC)n1 Show InChI InChI=1S/C19H22N4O3S2/c1-12-17(28-19(21-12)27-10-9-24-2)15-7-8-20-18(23-15)22-14-6-5-13(25-3)11-16(14)26-4/h5-8,11H,9-10H2,1-4H3,(H,20,22,23)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	64	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563304 (CHEMBL4749963) Show SMILES Clc1cncc(-c2cncc3ccccc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	66	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130702 (CHEMBL3632742) Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(O)=O)c(C)c12 Show InChI InChI=1S/C17H16FN3O3S/c1-8(2)24-12-6-10(18)4-5-11(12)21-15-13-9(3)14(17(22)23)25-16(13)20-7-19-15/h4-8H,1-3H3,(H,22,23)(H,19,20,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents	Article PubMed	68	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563316 (CHEMBL4797631) Show SMILES Cn1c(cc2ccccc12)-c1cncc(Cl)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130694 (CHEMBL3416305) Show SMILES CC(=O)C1=C(O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@@]2(C)C1=O |r,c:3,t:6| Show InChI InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,19-21H,1-2H3,(H2,17,23)/t16-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50277621 (CHEMBL4174540) Show SMILES COc1ccc(Nc2nccc(n2)-c2sc(SCCN3CCOCC3)nc2C)c(OC)c1 Show InChI InChI=1S/C22H27N5O3S2/c1-15-20(32-22(24-15)31-13-10-27-8-11-30-12-9-27)18-6-7-23-21(26-18)25-17-5-4-16(28-2)14-19(17)29-3/h4-7,14H,8-13H2,1-3H3,(H,23,25,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	93	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Tested for affinity towards H1 receptor in guinea pig ileum				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50277620 (CHEMBL4163881) Show SMILES COc1ccc(Nc2nccc(n2)-c2sc(SCCN3CCNCC3)nc2C)c(OC)c1 Show InChI InChI=1S/C22H28N6O2S2/c1-15-20(32-22(25-15)31-13-12-28-10-8-23-9-11-28)18-6-7-24-21(27-18)26-17-5-4-16(29-2)14-19(17)30-3/h4-7,14,23H,8-13H2,1-3H3,(H,24,26,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of recombinant human FLT3 using EAIYAAPFAKKK as substrate by ATP-Glo assay				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50130704 (CHEMBL3632744) Show SMILES CNC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C Show InChI InChI=1S/C18H19FN4O2S/c1-9(2)25-13-7-11(19)5-6-12(13)23-16-14-10(3)15(17(24)20-4)26-18(14)22-8-21-16/h5-9H,1-4H3,(H,20,24)(H,21,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	106	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of Mnk1a (unknown origin) using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after ...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM50563322 (CHEMBL4777349) Show SMILES Clc1cncc(-c2cc3ccccc3o2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	109	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human full length PKCtheta using histone H1 as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50130703 (CHEMBL3632743) Show SMILES CC(C)Oc1cc(F)ccc1Nc1ncnc2sc(C(N)=O)c(C)c12 Show InChI InChI=1S/C17H17FN4O2S/c1-8(2)24-12-6-10(18)4-5-11(12)22-16-13-9(3)14(15(19)23)25-17(13)21-7-20-16/h4-8H,1-3H3,(H2,19,23)(H,20,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of human Mnk2a using TAMRA-labeled eIF4E peptide as substrate incubated for 10 mins followed by addition of ATP measured after 90 mins by ...				Eur J Med Chem 103: 539-50 (2015) Article DOI: 10.1016/j.ejmech.2015.09.008 BindingDB Entry DOI: 10.7270/Q2S184B8
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50277602 (CHEMBL4164283) Show SMILES CNc1nc(C)c(s1)-c1ccnc(Nc2ccc(OC)cc2OC)n1 Show InChI InChI=1S/C17H19N5O2S/c1-10-15(25-17(18-2)20-10)13-7-8-19-16(22-13)21-12-6-5-11(23-3)9-14(12)24-4/h5-9H,1-4H3,(H,18,20)(H,19,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of recombinant full length human N-terminal GST-tagged MNK2 expressed in baculovirus expression system using N-terminal TAMRA-labeled eIF4...				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50277608 (CHEMBL4173067) Show SMILES COc1ccc(Nc2nccc(n2)-c2c[nH]c3ccccc23)c(OC)c1 Show InChI InChI=1S/C20H18N4O2/c1-25-13-7-8-18(19(11-13)26-2)24-20-21-10-9-17(23-20)15-12-22-16-6-4-3-5-14(15)16/h3-12,22H,1-2H3,(H,21,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of recombinant full length human N-terminal GST-tagged MNK2 expressed in baculovirus expression system using N-terminal TAMRA-labeled eIF4...				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563309 (CHEMBL4740495) Show SMILES Clc1cncc(-c2cccc3cccnc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	114	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM50277618 (CHEMBL4165526) Show SMILES Oc1ccccc1Nc1nccc(n1)-c1c[nH]c2ccccc12 Show InChI InChI=1S/C18H14N4O/c23-17-8-4-3-7-16(17)22-18-19-10-9-15(21-18)13-11-20-14-6-2-1-5-12(13)14/h1-11,20,23H,(H,19,21,22)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of South Australia Curated by ChEMBL					Assay Description Inhibition of recombinant full length human N-terminal GST-tagged MNK2 expressed in baculovirus expression system using N-terminal TAMRA-labeled eIF4...				Eur J Med Chem 139: 762-772 (2017) Article DOI: 10.1016/j.ejmech.2017.08.006 BindingDB Entry DOI: 10.7270/Q24B33VW
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563298 (CHEMBL4763695) Show SMILES Clc1cncc(-c2cnn(c2)N2CCOCC2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	124	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Protein kinase C theta type (Homo sapiens (Human))	BDBM50563323 (CHEMBL4791586) Show SMILES Clc1cncc(-c2cc3ccccc3s2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	134	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human full length PKCtheta using histone H1 as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563305 (CHEMBL4780661) Show SMILES Clc1cncc(-c2ccnc3ccccc23)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	138	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair
Cyclin-C (Homo sapiens (Human))	BDBM50563315 (CHEMBL4752645) Show SMILES Clc1cncc(-c2cc3ccccc3[nH]2)c1N1CCC2(CCNC2=O)CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	156	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of CDK8/cyclin C (unknown origin) using RBER-IRStide as substrate incubated for 60 mins in presence of [gamma33P]ATP by scintillation coun...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113248 BindingDB Entry DOI: 10.7270/Q2930XW8
					More data for this Ligand-Target Pair

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