Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156246 (US9018391, 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150700 (US8981112, 7 | US9526727, 7 | US9949975, Example 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute | Assay Description Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta... | J Med Chem 52: 336-46 (2009) BindingDB Entry DOI: 10.7270/Q25D8V5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111911 (US8623901, 239) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 [1-454] (Homo sapiens (Human)) | BDBM150700 (US8981112, 7 | US9526727, 7 | US9949975, Example 7) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceutical, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9526727 (2016) BindingDB Entry DOI: 10.7270/Q2K936GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150700 (US8981112, 7 | US9526727, 7 | US9949975, Example 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer-Ingelheim International GmbH US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US8981112 (2015) BindingDB Entry DOI: 10.7270/Q2B56HG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156243 (US9018391, 5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156242 (US9018391, 4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150705 (US8981112, 12 | US9526727, 12 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute | Assay Description Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta... | J Med Chem 52: 336-46 (2009) BindingDB Entry DOI: 10.7270/Q25D8V5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156241 (US9018391, 3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150705 (US8981112, 12 | US9526727, 12 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer-Ingelheim International GmbH US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US8981112 (2015) BindingDB Entry DOI: 10.7270/Q2B56HG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111910 (US8623901, 234) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 [1-454] (Homo sapiens (Human)) | BDBM150705 (US8981112, 12 | US9526727, 12 | US9949975, Example...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceutical, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9526727 (2016) BindingDB Entry DOI: 10.7270/Q2K936GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156245 (US9018391, 7) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111932 (US8623901, 261) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 [1-454] (Homo sapiens (Human)) | BDBM150704 (US8981112, 11 | US9526727, 11 | US9949975, Example...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceutical, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9526727 (2016) BindingDB Entry DOI: 10.7270/Q2K936GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150704 (US8981112, 11 | US9526727, 11 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute | Assay Description Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta... | J Med Chem 52: 336-46 (2009) BindingDB Entry DOI: 10.7270/Q25D8V5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150704 (US8981112, 11 | US9526727, 11 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer-Ingelheim International GmbH US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US8981112 (2015) BindingDB Entry DOI: 10.7270/Q2B56HG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM156252 (US9018391, 14) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Boehringer Ingelheim International GmbH; Vitae Pharmaceuticals, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9018391 (2015) BindingDB Entry DOI: 10.7270/Q2QN65HR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111912 (US8623901, 240) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111892 (US8623901, 220) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111896 (US8623901, 223) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111904 (US8623901, 230-1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111905 (US8623901, 230-2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111928 (US8623901, 256) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150697 (US8981112, 4 | US9526727, 4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer-Ingelheim International GmbH US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US8981112 (2015) BindingDB Entry DOI: 10.7270/Q2B56HG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150701 (US8981112, 8 | US9526727, 8 | US9949975, Example 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer-Ingelheim International GmbH US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US8981112 (2015) BindingDB Entry DOI: 10.7270/Q2B56HG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150707 (US8981112, 14 | US9526727, 14 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer-Ingelheim International GmbH US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US8981112 (2015) BindingDB Entry DOI: 10.7270/Q2B56HG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150714 (US8981112, 21 | US9526727, 21 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer-Ingelheim International GmbH US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US8981112 (2015) BindingDB Entry DOI: 10.7270/Q2B56HG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150717 (US8981112, 24 | US9526727, 24 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceuticals, Inc.; Boehringer-Ingelheim International GmbH US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US8981112 (2015) BindingDB Entry DOI: 10.7270/Q2B56HG6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 [1-454] (Homo sapiens (Human)) | BDBM150697 (US8981112, 4 | US9526727, 4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceutical, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9526727 (2016) BindingDB Entry DOI: 10.7270/Q2K936GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 [1-454] (Homo sapiens (Human)) | BDBM150701 (US8981112, 8 | US9526727, 8 | US9949975, Example 8) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceutical, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9526727 (2016) BindingDB Entry DOI: 10.7270/Q2K936GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 [1-454] (Homo sapiens (Human)) | BDBM150707 (US8981112, 14 | US9526727, 14 | US9949975, Example...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceutical, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9526727 (2016) BindingDB Entry DOI: 10.7270/Q2K936GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 [1-454] (Homo sapiens (Human)) | BDBM150714 (US8981112, 21 | US9526727, 21 | US9949975, Example...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceutical, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9526727 (2016) BindingDB Entry DOI: 10.7270/Q2K936GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 [1-454] (Homo sapiens (Human)) | BDBM150717 (US8981112, 24 | US9526727, 24 | US9949975, Example...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceutical, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9526727 (2016) BindingDB Entry DOI: 10.7270/Q2K936GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM389136 (US9949975, Example 4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute | Assay Description Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta... | J Med Chem 52: 336-46 (2009) BindingDB Entry DOI: 10.7270/Q25D8V5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150701 (US8981112, 8 | US9526727, 8 | US9949975, Example 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute | Assay Description Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta... | J Med Chem 52: 336-46 (2009) BindingDB Entry DOI: 10.7270/Q25D8V5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150707 (US8981112, 14 | US9526727, 14 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute | Assay Description Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta... | J Med Chem 52: 336-46 (2009) BindingDB Entry DOI: 10.7270/Q25D8V5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150714 (US8981112, 21 | US9526727, 21 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute | Assay Description Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta... | J Med Chem 52: 336-46 (2009) BindingDB Entry DOI: 10.7270/Q25D8V5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150717 (US8981112, 24 | US9526727, 24 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute | Assay Description Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta... | J Med Chem 52: 336-46 (2009) BindingDB Entry DOI: 10.7270/Q25D8V5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 [1-454] (Homo sapiens (Human)) | BDBM150712 (US8981112, 19 | US9526727, 19 | US9949975, Example...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceutical, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9526727 (2016) BindingDB Entry DOI: 10.7270/Q2K936GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 [1-454] (Homo sapiens (Human)) | BDBM150720 (US8981112, 27 | US9526727, 27 | US9949975, Example...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 4.4 | n/a |
Vitae Pharmaceutical, Inc. US Patent | Assay Description The inhibitory activity of compounds was assessed by a fluorescence quench assay of BACE1 activity using commercially available substrate HiLyte Fluo... | US Patent US9526727 (2016) BindingDB Entry DOI: 10.7270/Q2K936GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM50210579 ((2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-2-benz...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid UniChem Similars | MMDB Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universität München Curated by ChEMBL | Assay Description Inhibition of human BACE1 expressed in HEK293 cells | Bioorg Med Chem 15: 4136-43 (2007) Article DOI: 10.1016/j.bmc.2007.03.072 BindingDB Entry DOI: 10.7270/Q24M9478 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM50210579 ((2S,5S,8S,11R,13S,14S,17S,20S,23S)-23-amino-2-benz...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid UniChem Similars | MMDB Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t M£nchen Curated by ChEMBL | Assay Description Inhibition of full-domain of BACE1 expressed in HEK393 cells | Bioorg Med Chem Lett 19: 4427-31 (2009) Article DOI: 10.1016/j.bmcl.2009.05.053 BindingDB Entry DOI: 10.7270/Q2RF5V22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150712 (US8981112, 19 | US9526727, 19 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute | Assay Description Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta... | J Med Chem 52: 336-46 (2009) BindingDB Entry DOI: 10.7270/Q25D8V5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-secretase 1 (Homo sapiens (Human)) | BDBM150720 (US8981112, 27 | US9526727, 27 | US9949975, Example...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute | Assay Description Assay 1:The assay was performed in the presence of OptiMEM (supernatant collected over 24 h and cleared from cellular debris by centrifugation) conta... | J Med Chem 52: 336-46 (2009) BindingDB Entry DOI: 10.7270/Q25D8V5X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111894 (US8623901, 221) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111898 (US8623901, 225) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111901 (US8623901, 228) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111907 (US8623901, 230-5) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM111913 (US8623901, 241) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 0 |
Boehringer Ingelheim International GmbH US Patent | Assay Description The PDE9A2 enzymatic activity assay was run as scintillation proximity assay (SPA), in general according to the protocol of the manufacturer (GE Heal... | US Patent US8623901 (2014) BindingDB Entry DOI: 10.7270/Q2Z036TP | |||||||||||
More data for this Ligand-Target Pair |
Displayed 1 to 50 (of 183 total ) | Next | Last >> |