Found 1025 hits with Last Name = 'dwight' and Initial = 'w' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50222968
(Cipralisant | GT-2331)Show InChI InChI=1S/C14H20N2/c1-14(2,3)7-5-4-6-11-8-12(11)13-9-15-10-16-13/h9-12H,5,7-8H2,1-3H3,(H,15,16)/t11-,12-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| 0.195 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards rat cortical H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50370569
(A-349,821 | A-349821)Show SMILES C[C@H]1CC[C@H](C)N1CCCOc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H34N2O3/c1-20-4-5-21(2)28(20)14-3-17-31-25-12-10-23(11-13-25)22-6-8-24(9-7-22)26(29)27-15-18-30-19-16-27/h6-13,20-21H,3-5,14-19H2,1-2H3/t20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| 0.490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220468
(CHEMBL61120)Show InChI InChI=1S/C20H29N3O3/c21-9-8-19(24)23-13-11-22(12-14-23)10-1-15-26-18-6-4-17(5-7-18)20(25)16-2-3-16/h4-7,16H,1-3,8-15,21H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50222963
(CHEMBL24863)Show SMILES C[C@H]1CC[C@H](C)N1CCCOc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCC(C)CC1 Show InChI InChI=1S/C28H38N2O2/c1-21-15-18-29(19-16-21)28(31)26-9-7-24(8-10-26)25-11-13-27(14-12-25)32-20-4-17-30-22(2)5-6-23(30)3/h7-14,21-23H,4-6,15-20H2,1-3H3/t22-,23-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.603 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50217410
(CHEMBL105762)Show SMILES C[C@@H]1CC[C@@H](C)N1CCCOc1ccc(cc1)-c1ccc(cc1)C#N Show InChI InChI=1S/C22H26N2O/c1-17-4-5-18(2)24(17)14-3-15-25-22-12-10-21(11-13-22)20-8-6-19(16-23)7-9-20/h6-13,17-18H,3-5,14-15H2,1-2H3/t17-,18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.676 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity at human cloned Histamine H3 receptor |
Bioorg Med Chem Lett 12: 3077-9 (2002)
BindingDB Entry DOI: 10.7270/Q2ZW1P38 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50222941
(CHEMBL27501)Show SMILES C[C@H]1CC[C@H](C)N1CCCOc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCCC1 Show InChI InChI=1S/C26H34N2O2/c1-20-6-7-21(2)28(20)18-5-19-30-25-14-12-23(13-15-25)22-8-10-24(11-9-22)26(29)27-16-3-4-17-27/h8-15,20-21H,3-7,16-19H2,1-2H3/t20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.692 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190927
(CHEMBL214513 | N-((S)-1-((R)-3-(4,4-dimethylcycloh...)Show SMILES CCc1ccc(cc1)-c1ccc(s1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCC(C)(C)CC1 Show InChI InChI=1S/C31H44N4O2S/c1-5-22-6-8-23(9-7-22)27-10-11-28(38-27)29(36)33(4)26-15-19-35(21-26)30(37)34-18-14-25(20-34)32-24-12-16-31(2,3)17-13-24/h6-11,24-26,32H,5,12-21H2,1-4H3/t25-,26+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049 BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50223041
(CHEMBL280590)Show SMILES C[C@H]1CC[C@H](C)N1CCCOc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCCC1C Show InChI InChI=1S/C27H36N2O2/c1-20-6-4-17-29(20)27(30)25-11-9-23(10-12-25)24-13-15-26(16-14-24)31-19-5-18-28-21(2)7-8-22(28)3/h9-16,20-22H,4-8,17-19H2,1-3H3/t20?,21-,22-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Similars
| PubMed
| 0.776 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50223042
(CHEMBL283313)Show SMILES CCN(CC)C(=O)c1ccc(cc1)-c1ccc(OCCCN2[C@@H](C)CC[C@@H]2C)cc1 Show InChI InChI=1S/C26H36N2O2/c1-5-27(6-2)26(29)24-12-10-22(11-13-24)23-14-16-25(17-15-23)30-19-7-18-28-20(3)8-9-21(28)4/h10-17,20-21H,5-9,18-19H2,1-4H3/t20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.776 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50223048
(CHEMBL25519)Show SMILES CC(C)NC(=O)c1ccc(cc1)-c1ccc(OCCCN2[C@@H](C)CC[C@@H]2C)cc1 Show InChI InChI=1S/C25H34N2O2/c1-18(2)26-25(28)23-10-8-21(9-11-23)22-12-14-24(15-13-22)29-17-5-16-27-19(3)6-7-20(27)4/h8-15,18-20H,5-7,16-17H2,1-4H3,(H,26,28)/t19-,20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.851 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190919
(CHEMBL386454 | N-((S)-1-((R)-3-(4,4-dimethylcycloh...)Show SMILES COc1ccc(cc1)-c1ccc(s1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCC(C)(C)CC1 Show InChI InChI=1S/C30H42N4O3S/c1-30(2)15-11-22(12-16-30)31-23-13-17-33(19-23)29(36)34-18-14-24(20-34)32(3)28(35)27-10-9-26(38-27)21-5-7-25(37-4)8-6-21/h5-10,22-24,31H,11-20H2,1-4H3/t23-,24+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049 BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50222951
(CHEMBL27933)Show SMILES C[C@H]1CC[C@H](C)N1CCCOc1ccc(cc1)-c1ccc(cc1)C(=O)N1[C@@H](C)CC[C@@H]1C Show InChI InChI=1S/C28H38N2O2/c1-20-6-7-21(2)29(20)18-5-19-32-27-16-14-25(15-17-27)24-10-12-26(13-11-24)28(31)30-22(3)8-9-23(30)4/h10-17,20-23H,5-9,18-19H2,1-4H3/t20-,21-,22-,23-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 0.977 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50223041
(CHEMBL280590)Show SMILES C[C@H]1CC[C@H](C)N1CCCOc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCCC1C Show InChI InChI=1S/C27H36N2O2/c1-20-6-4-17-29(20)27(30)25-11-9-23(10-12-25)24-13-15-26(16-14-24)31-19-5-18-28-21(2)7-8-22(28)3/h9-16,20-22H,4-8,17-19H2,1-3H3/t20?,21-,22-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Similars
| PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards rat cortical H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50222973
(CHEMBL26880)Show SMILES O=C(N1CCCC1)c1ccc(cc1)-c1ccc(OCCCN2CCCC2)cc1 Show InChI InChI=1S/C24H30N2O2/c27-24(26-17-3-4-18-26)22-8-6-20(7-9-22)21-10-12-23(13-11-21)28-19-5-16-25-14-1-2-15-25/h6-13H,1-5,14-19H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220419
(CHEMBL63125)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)[C@@H](C)NC(=O)OC(C)(C)C)cc1 Show InChI InChI=1S/C27H43N3O5/c1-6-7-8-10-24(31)22-11-13-23(14-12-22)34-20-9-15-29-16-18-30(19-17-29)25(32)21(2)28-26(33)35-27(3,4)5/h11-14,21H,6-10,15-20H2,1-5H3,(H,28,33)/t21-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220473
(CHEMBL305144)Show SMILES O=C(C1CC1)c1ccc(OCCCN2CCN(CC2)C(=O)[C@H]2CCN2)cc1 Show InChI InChI=1S/C21H29N3O3/c25-20(16-2-3-16)17-4-6-18(7-5-17)27-15-1-10-23-11-13-24(14-12-23)21(26)19-8-9-22-19/h4-7,16,19,22H,1-3,8-15H2/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50139308
((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)Show SMILES C[C@@H](N)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C20H29N3O3/c1-15(21)20(25)23-12-10-22(11-13-23)9-2-14-26-18-7-5-17(6-8-18)19(24)16-3-4-16/h5-8,15-16H,2-4,9-14,21H2,1H3/t15-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119707
(4-[3-(4-Hexanoyl-phenoxy)-propyl]-piperazine-1-car...)Show InChI InChI=1S/C22H34N2O4/c1-3-5-6-8-21(25)19-9-11-20(12-10-19)28-18-7-13-23-14-16-24(17-15-23)22(26)27-4-2/h9-12H,3-8,13-18H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 1.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119704
(CHEMBL104809 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES Fc1cccc(c1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C23H27FN2O4S/c24-19-3-1-4-22(15-19)31(28,29)25-20-11-13-26(16-20)12-2-14-30-21-9-7-18(8-10-21)23(27)17-5-6-17/h1,3-4,7-10,15,17,20,25H,2,5-6,11-14,16H2/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190948
(CHEMBL442064 | N-((S)-1-((R)-3-(4,4-dimethylcycloh...)Show SMILES CN([C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCC(C)(C)CC1)C(=O)c1ccc(s1)-c1ccc(C)cc1 Show InChI InChI=1S/C30H42N4O2S/c1-21-5-7-22(8-6-21)26-9-10-27(37-26)28(35)32(4)25-14-18-34(20-25)29(36)33-17-13-24(19-33)31-23-11-15-30(2,3)16-12-23/h5-10,23-25,31H,11-20H2,1-4H3/t24-,25+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049 BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50370569
(A-349,821 | A-349821)Show SMILES C[C@H]1CC[C@H](C)N1CCCOc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCOCC1 Show InChI InChI=1S/C26H34N2O3/c1-20-4-5-21(2)28(20)14-3-17-31-25-12-10-23(11-13-25)22-6-8-24(9-7-22)26(29)27-15-18-30-19-16-27/h6-13,20-21H,3-5,14-19H2,1-2H3/t20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards rat cortical H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50217412
(CHEMBL322873)Show InChI InChI=1S/C22H26N2O/c1-18-4-2-13-24(17-18)14-3-15-25-22-11-9-21(10-12-22)20-7-5-19(16-23)6-8-20/h5-12,18H,2-4,13-15,17H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity at human cloned Histamine H3 receptor |
Bioorg Med Chem Lett 12: 3077-9 (2002)
BindingDB Entry DOI: 10.7270/Q2ZW1P38 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190943
(5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-((S)-1-(...)Show SMILES CN([C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCC(C)(C)CC1)C(=O)c1ccc(s1)-c1ccc2OCCOc2c1 Show InChI InChI=1S/C31H42N4O4S/c1-31(2)12-8-22(9-13-31)32-23-10-14-34(19-23)30(37)35-15-11-24(20-35)33(3)29(36)28-7-6-27(40-28)21-4-5-25-26(18-21)39-17-16-38-25/h4-7,18,22-24,32H,8-17,19-20H2,1-3H3/t23-,24+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049 BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220430
(CHEMBL302829)Show SMILES CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C21H31N3O3/c1-2-19(22)21(26)24-13-11-23(12-14-24)10-3-15-27-18-8-6-17(7-9-18)20(25)16-4-5-16/h6-9,16,19H,2-5,10-15,22H2,1H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220467
(CHEMBL62421)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)[C@@H](C)N)cc1 Show InChI InChI=1S/C22H35N3O3/c1-3-4-5-7-21(26)19-8-10-20(11-9-19)28-17-6-12-24-13-15-25(16-14-24)22(27)18(2)23/h8-11,18H,3-7,12-17,23H2,1-2H3/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220430
(CHEMBL302829)Show SMILES CC[C@@H](N)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C21H31N3O3/c1-2-19(22)21(26)24-13-11-23(12-14-24)10-3-15-27-18-8-6-17(7-9-18)20(25)16-4-5-16/h6-9,16,19H,2-5,10-15,22H2,1H3/t19-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 1.95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119707
(4-[3-(4-Hexanoyl-phenoxy)-propyl]-piperazine-1-car...)Show InChI InChI=1S/C22H34N2O4/c1-3-5-6-8-21(25)19-9-11-20(12-10-19)28-18-7-13-23-14-16-24(17-15-23)22(26)27-4-2/h9-12H,3-8,13-18H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity of the compound towards rats Histamine type 3 (H3) receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50223042
(CHEMBL283313)Show SMILES CCN(CC)C(=O)c1ccc(cc1)-c1ccc(OCCCN2[C@@H](C)CC[C@@H]2C)cc1 Show InChI InChI=1S/C26H36N2O2/c1-5-27(6-2)26(29)24-12-10-22(11-13-24)23-14-16-25(17-15-23)30-19-7-18-28-20(3)8-9-21(28)4/h10-17,20-21H,5-9,18-19H2,1-4H3/t20-,21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards rat cortical H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190922
(5-(4-ethylphenyl)-N-methyl-N-((S)-1-((R)-3-(tetrah...)Show SMILES CCc1ccc(cc1)-c1ccc(s1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCOCC1 Show InChI InChI=1S/C28H38N4O3S/c1-3-20-4-6-21(7-5-20)25-8-9-26(36-25)27(33)30(2)24-11-15-32(19-24)28(34)31-14-10-23(18-31)29-22-12-16-35-17-13-22/h4-9,22-24,29H,3,10-19H2,1-2H3/t23-,24+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049 BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190931
(CHEMBL265255 | N-((S)-1-((R)-3-(cyclopentylamino)p...)Show SMILES CCc1ccc(cc1)-c1ccc(s1)C(=O)N(C)[C@H]1CCN(C1)C(=O)N1CC[C@H](C1)NC1CCCC1 Show InChI InChI=1S/C28H38N4O2S/c1-3-20-8-10-21(11-9-20)25-12-13-26(35-25)27(33)30(2)24-15-17-32(19-24)28(34)31-16-14-23(18-31)29-22-6-4-5-7-22/h8-13,22-24,29H,3-7,14-19H2,1-2H3/t23-,24+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049 BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50222948
(CHEMBL25342)Show SMILES CC(C)NC(=O)c1ccc(cc1)-c1ccc(OCCCN2CCC(C)CC2)cc1 Show InChI InChI=1S/C25H34N2O2/c1-19(2)26-25(28)23-7-5-21(6-8-23)22-9-11-24(12-10-22)29-18-4-15-27-16-13-20(3)14-17-27/h5-12,19-20H,4,13-18H2,1-3H3,(H,26,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50222950
(CHEMBL279463)Show SMILES CCN(CC)CCCOc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCCC1C Show InChI InChI=1S/C25H34N2O2/c1-4-26(5-2)17-7-19-29-24-15-13-22(14-16-24)21-9-11-23(12-10-21)25(28)27-18-6-8-20(27)3/h9-16,20H,4-8,17-19H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50222968
(Cipralisant | GT-2331)Show InChI InChI=1S/C14H20N2/c1-14(2,3)7-5-4-6-11-8-12(11)13-9-15-10-16-13/h9-12H,5,7-8H2,1-3H3,(H,15,16)/t11-,12-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50217416
(CHEMBL105515)Show InChI InChI=1S/C23H28N2O/c1-18-5-3-6-19(2)25(18)15-4-16-26-23-13-11-22(12-14-23)21-9-7-20(17-24)8-10-21/h7-14,18-19H,3-6,15-16H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity at human cloned Histamine H3 receptor |
Bioorg Med Chem Lett 12: 3077-9 (2002)
BindingDB Entry DOI: 10.7270/Q2ZW1P38 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220338
(CHEMBL302886)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)C2CC2)cc1 Show InChI InChI=1S/C23H34N2O3/c1-2-3-4-6-22(26)19-9-11-21(12-10-19)28-18-5-13-24-14-16-25(17-15-24)23(27)20-7-8-20/h9-12,20H,2-8,13-18H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for the rat cortical Histamine H3 receptor |
Bioorg Med Chem Lett 12: 2031-4 (2002)
BindingDB Entry DOI: 10.7270/Q2MK6G21 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220417
(CHEMBL64406)Show SMILES C[C@@H](NC(=O)OC(C)(C)C)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C25H37N3O5/c1-18(26-24(31)33-25(2,3)4)23(30)28-15-13-27(14-16-28)12-5-17-32-21-10-8-20(9-11-21)22(29)19-6-7-19/h8-11,18-19H,5-7,12-17H2,1-4H3,(H,26,31)/t18-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190941
(CHEMBL387013 | N-((S)-1-((R)-3-(3-cyclohexylpropyl...)Show SMILES COc1ccc(-c2ccc(s2)C(=O)N(C)[C@H]2CCN(C2)C(=O)N2CC[C@H](C2)NCCCC2CCCCC2)c(C)c1 Show InChI InChI=1S/C32H46N4O3S/c1-23-20-27(39-3)11-12-28(23)29-13-14-30(40-29)31(37)34(2)26-16-19-36(22-26)32(38)35-18-15-25(21-35)33-17-7-10-24-8-5-4-6-9-24/h11-14,20,24-26,33H,4-10,15-19,21-22H2,1-3H3/t25-,26+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049 BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220422
(CHEMBL60401)Show InChI InChI=1S/C20H29N3O3/c1-21-15-19(24)23-12-10-22(11-13-23)9-2-14-26-18-7-5-17(6-8-18)20(25)16-3-4-16/h5-8,16,21H,2-4,9-15H2,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220449
(CHEMBL60837)Show SMILES CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)[C@@H](CO)NC(=O)OC(C)(C)C)cc1 Show InChI InChI=1S/C27H43N3O6/c1-5-6-7-9-24(32)21-10-12-22(13-11-21)35-19-8-14-29-15-17-30(18-16-29)25(33)23(20-31)28-26(34)36-27(2,3)4/h10-13,23,31H,5-9,14-20H2,1-4H3,(H,28,34)/t23-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50222964
(CHEMBL27697)Show SMILES CCN(CC)CCCOc1ccc(cc1)-c1ccc(cc1)C(=O)N1CCOCC1 Show InChI InChI=1S/C24H32N2O3/c1-3-25(4-2)14-5-17-29-23-12-10-21(11-13-23)20-6-8-22(9-7-20)24(27)26-15-18-28-19-16-26/h6-13H,3-5,14-19H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50190940
(CHEMBL383933 | N-((S)-1-((R)-3-(4,4-dimethylcycloh...)Show SMILES COc1ccc(-c2ccc(s2)C(=O)N(C)[C@H]2CCN(C2)C(=O)N2CC[C@H](C2)NC2CCC(C)(C)CC2)c(C)c1 Show InChI InChI=1S/C31H44N4O3S/c1-21-18-25(38-5)6-7-26(21)27-8-9-28(39-27)29(36)33(4)24-13-17-35(20-24)30(37)34-16-12-23(19-34)32-22-10-14-31(2,3)15-11-22/h6-9,18,22-24,32H,10-17,19-20H2,1-5H3/t23-,24+/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences Inc.
Curated by ChEMBL
| Assay Description Binding affinity to MCHR1 by competitive binding assay |
Bioorg Med Chem Lett 16: 4922-30 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.049 BindingDB Entry DOI: 10.7270/Q2TM7BX5 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50220428
(CHEMBL418666)Show SMILES CC[C@H](N)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1 Show InChI InChI=1S/C21H31N3O3/c1-2-19(22)21(26)24-13-11-23(12-14-24)10-3-15-27-18-8-6-17(7-9-18)20(25)16-4-5-16/h6-9,16,19H,2-5,10-15,22H2,1H3/t19-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards Histamine H3 receptor of rat cortical membranes. |
Bioorg Med Chem Lett 12: 2035-7 (2002)
BindingDB Entry DOI: 10.7270/Q2RB75SX |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119710
(CHEMBL104618 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES Fc1ccccc1S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C23H27FN2O4S/c24-21-4-1-2-5-22(21)31(28,29)25-19-12-14-26(16-19)13-3-15-30-20-10-8-18(9-11-20)23(27)17-6-7-17/h1-2,4-5,8-11,17,19,25H,3,6-7,12-16H2/t19-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119721
(CHEMBL103027 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES Cc1cccc(c1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C24H30N2O4S/c1-18-4-2-5-23(16-18)31(28,29)25-21-12-14-26(17-21)13-3-15-30-22-10-8-20(9-11-22)24(27)19-6-7-19/h2,4-5,8-11,16,19,21,25H,3,6-7,12-15,17H2,1H3/t21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50223048
(CHEMBL25519)Show SMILES CC(C)NC(=O)c1ccc(cc1)-c1ccc(OCCCN2[C@@H](C)CC[C@@H]2C)cc1 Show InChI InChI=1S/C25H34N2O2/c1-18(2)26-25(28)23-10-8-21(9-11-23)22-12-14-24(15-13-22)29-17-5-16-27-19(3)6-7-20(27)4/h8-15,18-20H,5-7,16-17H2,1-4H3,(H,26,28)/t19-,20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards rat cortical H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50240709
((R)-4'-(3-(3-(dimethylamino)pyrrolidin-1-yl)propox...)Show SMILES CN(C)[C@@H]1CCN(CCCOc2ccc(cc2)-c2ccc(cc2)C#N)C1 |r| Show InChI InChI=1S/C22H27N3O/c1-24(2)21-12-14-25(17-21)13-3-15-26-22-10-8-20(9-11-22)19-6-4-18(16-23)5-7-19/h4-11,21H,3,12-15,17H2,1-2H3/t21-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity at human cloned Histamine H3 receptor |
Bioorg Med Chem Lett 12: 3077-9 (2002)
BindingDB Entry DOI: 10.7270/Q2ZW1P38 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50223038
(CHEMBL433031)Show SMILES CC1CCCN1C(=O)c1ccc(cc1)-c1ccc(OCCCN2CCC(C)CC2)cc1 Show InChI InChI=1S/C27H36N2O2/c1-21-14-18-28(19-15-21)16-4-20-31-26-12-10-24(11-13-26)23-6-8-25(9-7-23)27(30)29-17-3-5-22(29)2/h6-13,21-22H,3-5,14-20H2,1-2H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity towards rat cortical H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119735
(3-Cyano-N-{(S)-1-[3-(4-cyclopropanecarbonyl-phenox...)Show SMILES O=C(C1CC1)c1ccc(OCCCN2CC[C@@H](C2)NS(=O)(=O)c2cccc(c2)C#N)cc1 Show InChI InChI=1S/C24H27N3O4S/c25-16-18-3-1-4-23(15-18)32(29,30)26-21-11-13-27(17-21)12-2-14-31-22-9-7-20(8-10-22)24(28)19-5-6-19/h1,3-4,7-10,15,19,21,26H,2,5-6,11-14,17H2/t21-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Rattus norvegicus (rat)) | BDBM50119722
(CHEMBL107162 | N-{(S)-1-[3-(4-Cyclopropanecarbonyl...)Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@H]1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)C1 Show InChI InChI=1S/C24H30N2O5S/c1-30-21-9-11-23(12-10-21)32(28,29)25-20-13-15-26(17-20)14-2-16-31-22-7-5-19(6-8-22)24(27)18-3-4-18/h5-12,18,20,25H,2-4,13-17H2,1H3/t20-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity against rat histamine H3 receptor |
Bioorg Med Chem Lett 12: 3055-8 (2002)
BindingDB Entry DOI: 10.7270/Q2B56J3P |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(Homo sapiens (Human)) | BDBM50222957
(CHEMBL2113223)Show SMILES CN(C)[C@@H]1CCN(CCCOc2ccc(cc2)-c2ccc(cc2)C(=O)N2CCCC2)C1 Show InChI InChI=1S/C26H35N3O2/c1-27(2)24-14-18-28(20-24)15-5-19-31-25-12-10-22(11-13-25)21-6-8-23(9-7-21)26(30)29-16-3-4-17-29/h6-13,24H,3-5,14-20H2,1-2H3/t24-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity for human recombinant H3 receptor |
Bioorg Med Chem Lett 13: 1325-8 (2003)
BindingDB Entry DOI: 10.7270/Q2HM59NM |
More data for this Ligand-Target Pair | |