Found 115 hits with Last Name = 'eden' and Initial = 'pe' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50091652
(CHEMBL269503 | PYY | PYY, rat | Peptide YY(PYY)(YP...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C190H287N53O58/c1-92(2)74-124(166(280)216-114(27-18-66-204-187(195)196)158(272)231-131(83-107-86-203-91-209-107)171(285)230-130(81-105-41-51-111(251)52-42-105)169(283)225-125(75-93(3)4)167(281)232-132(84-143(194)254)172(286)226-127(77-95(7)8)173(287)238-150(96(9)10)180(294)239-151(101(15)247)181(295)222-117(30-21-69-207-190(201)202)156(270)218-119(55-60-142(193)253)161(275)215-116(29-20-68-206-189(199)200)159(273)234-134(186(300)301)82-106-43-53-112(252)54-44-106)227-175(289)135(88-244)235-153(267)97(11)210-164(278)128(79-103-37-47-109(249)48-38-103)229-170(284)129(80-104-39-49-110(250)50-40-104)228-157(271)115(28-19-67-205-188(197)198)217-174(288)136(89-245)236-168(282)126(76-94(5)6)224-163(277)121(58-63-147(260)261)219-162(276)122(59-64-148(262)263)221-179(293)141-34-25-73-243(141)185(299)137(90-246)237-154(268)98(12)211-165(279)133(85-149(264)265)233-160(274)118(56-61-145(256)257)214-144(255)87-208-176(290)138-31-22-70-240(138)182(296)100(14)213-155(269)120(57-62-146(258)259)220-178(292)140-33-24-72-242(140)184(298)123(26-16-17-65-191)223-152(266)99(13)212-177(291)139-32-23-71-241(139)183(297)113(192)78-102-35-45-108(248)46-36-102/h35-54,86,91-101,113-141,150-151,244-252H,16-34,55-85,87-90,191-192H2,1-15H3,(H2,193,253)(H2,194,254)(H,203,209)(H,208,290)(H,210,278)(H,211,279)(H,212,291)(H,213,269)(H,214,255)(H,215,275)(H,216,280)(H,217,288)(H,218,270)(H,219,276)(H,220,292)(H,221,293)(H,222,295)(H,223,266)(H,224,277)(H,225,283)(H,226,286)(H,227,289)(H,228,271)(H,229,284)(H,230,285)(H,231,272)(H,232,281)(H,233,274)(H,234,273)(H,235,267)(H,236,282)(H,237,268)(H,238,287)(H,239,294)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,300,301)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207)/t97-,98-,99-,100-,101+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,150-,151-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091672
(CHEMBL412704 | N-alpha-Ac-[CH2-NH35-36]PYY(22-36)-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C86H141N29O21/c1-42(2)31-59(109-81(134)65(40-116)113-71(124)46(9)102-48(11)118)75(128)104-55(16-13-29-98-85(92)93)74(127)111-63(36-52-38-96-41-101-52)78(131)110-62(35-50-20-24-54(120)25-21-50)77(130)107-60(32-43(3)4)76(129)112-64(37-67(88)122)79(132)108-61(33-44(5)6)80(133)114-68(45(7)8)82(135)115-69(47(10)117)83(136)106-56(17-14-30-99-86(94)95)73(126)105-57(26-27-66(87)121)72(125)103-51(15-12-28-97-84(90)91)39-100-58(70(89)123)34-49-18-22-53(119)23-19-49/h18-25,38,41-47,51,55-65,68-69,100,116-117,119-120H,12-17,26-37,39-40H2,1-11H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,101)(H,102,118)(H,103,125)(H,104,128)(H,105,126)(H,106,136)(H,107,130)(H,108,132)(H,109,134)(H,110,131)(H,111,127)(H,112,129)(H,113,124)(H,114,133)(H,115,135)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t46-,47+,51-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,68-,69-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091652
(CHEMBL269503 | PYY | PYY, rat | Peptide YY(PYY)(YP...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C190H287N53O58/c1-92(2)74-124(166(280)216-114(27-18-66-204-187(195)196)158(272)231-131(83-107-86-203-91-209-107)171(285)230-130(81-105-41-51-111(251)52-42-105)169(283)225-125(75-93(3)4)167(281)232-132(84-143(194)254)172(286)226-127(77-95(7)8)173(287)238-150(96(9)10)180(294)239-151(101(15)247)181(295)222-117(30-21-69-207-190(201)202)156(270)218-119(55-60-142(193)253)161(275)215-116(29-20-68-206-189(199)200)159(273)234-134(186(300)301)82-106-43-53-112(252)54-44-106)227-175(289)135(88-244)235-153(267)97(11)210-164(278)128(79-103-37-47-109(249)48-38-103)229-170(284)129(80-104-39-49-110(250)50-40-104)228-157(271)115(28-19-67-205-188(197)198)217-174(288)136(89-245)236-168(282)126(76-94(5)6)224-163(277)121(58-63-147(260)261)219-162(276)122(59-64-148(262)263)221-179(293)141-34-25-73-243(141)185(299)137(90-246)237-154(268)98(12)211-165(279)133(85-149(264)265)233-160(274)118(56-61-145(256)257)214-144(255)87-208-176(290)138-31-22-70-240(138)182(296)100(14)213-155(269)120(57-62-146(258)259)220-178(292)140-33-24-72-242(140)184(298)123(26-16-17-65-191)223-152(266)99(13)212-177(291)139-32-23-71-241(139)183(297)113(192)78-102-35-45-108(248)46-36-102/h35-54,86,91-101,113-141,150-151,244-252H,16-34,55-85,87-90,191-192H2,1-15H3,(H2,193,253)(H2,194,254)(H,203,209)(H,208,290)(H,210,278)(H,211,279)(H,212,291)(H,213,269)(H,214,255)(H,215,275)(H,216,280)(H,217,288)(H,218,270)(H,219,276)(H,220,292)(H,221,293)(H,222,295)(H,223,266)(H,224,277)(H,225,283)(H,226,286)(H,227,289)(H,228,271)(H,229,284)(H,230,285)(H,231,272)(H,232,281)(H,233,274)(H,234,273)(H,235,267)(H,236,282)(H,237,268)(H,238,287)(H,239,294)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,300,301)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207)/t97-,98-,99-,100-,101+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,150-,151-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091652
(CHEMBL269503 | PYY | PYY, rat | Peptide YY(PYY)(YP...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C190H287N53O58/c1-92(2)74-124(166(280)216-114(27-18-66-204-187(195)196)158(272)231-131(83-107-86-203-91-209-107)171(285)230-130(81-105-41-51-111(251)52-42-105)169(283)225-125(75-93(3)4)167(281)232-132(84-143(194)254)172(286)226-127(77-95(7)8)173(287)238-150(96(9)10)180(294)239-151(101(15)247)181(295)222-117(30-21-69-207-190(201)202)156(270)218-119(55-60-142(193)253)161(275)215-116(29-20-68-206-189(199)200)159(273)234-134(186(300)301)82-106-43-53-112(252)54-44-106)227-175(289)135(88-244)235-153(267)97(11)210-164(278)128(79-103-37-47-109(249)48-38-103)229-170(284)129(80-104-39-49-110(250)50-40-104)228-157(271)115(28-19-67-205-188(197)198)217-174(288)136(89-245)236-168(282)126(76-94(5)6)224-163(277)121(58-63-147(260)261)219-162(276)122(59-64-148(262)263)221-179(293)141-34-25-73-243(141)185(299)137(90-246)237-154(268)98(12)211-165(279)133(85-149(264)265)233-160(274)118(56-61-145(256)257)214-144(255)87-208-176(290)138-31-22-70-240(138)182(296)100(14)213-155(269)120(57-62-146(258)259)220-178(292)140-33-24-72-242(140)184(298)123(26-16-17-65-191)223-152(266)99(13)212-177(291)139-32-23-71-241(139)183(297)113(192)78-102-35-45-108(248)46-36-102/h35-54,86,91-101,113-141,150-151,244-252H,16-34,55-85,87-90,191-192H2,1-15H3,(H2,193,253)(H2,194,254)(H,203,209)(H,208,290)(H,210,278)(H,211,279)(H,212,291)(H,213,269)(H,214,255)(H,215,275)(H,216,280)(H,217,288)(H,218,270)(H,219,276)(H,220,292)(H,221,293)(H,222,295)(H,223,266)(H,224,277)(H,225,283)(H,226,286)(H,227,289)(H,228,271)(H,229,284)(H,230,285)(H,231,272)(H,232,281)(H,233,274)(H,234,273)(H,235,267)(H,236,282)(H,237,268)(H,238,287)(H,239,294)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,300,301)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207)/t97-,98-,99-,100-,101+,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,150-,151-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091663
(CHEMBL214707 | N-alpha-Ac-[Trp30,CH2-NH-35-36]PYY(...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C91H140N30O21/c1-45(2)33-64(114-86(140)70(43-122)119-76(130)48(7)108-50(9)124)80(134)110-60(18-13-31-103-90(97)98)79(133)117-68(38-55-41-101-44-107-55)83(137)115-66(36-52-22-26-57(126)27-23-52)82(136)113-65(34-46(3)4)81(135)118-69(39-72(93)128)84(138)116-67(37-53-40-105-59-17-11-10-16-58(53)59)85(139)120-73(47(5)6)87(141)121-74(49(8)123)88(142)112-61(19-14-32-104-91(99)100)78(132)111-62(28-29-71(92)127)77(131)109-54(15-12-30-102-89(95)96)42-106-63(75(94)129)35-51-20-24-56(125)25-21-51/h10-11,16-17,20-27,40-41,44-49,54,60-70,73-74,105-106,122-123,125-126H,12-15,18-19,28-39,42-43H2,1-9H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,107)(H,108,124)(H,109,131)(H,110,134)(H,111,132)(H,112,142)(H,113,136)(H,114,140)(H,115,137)(H,116,138)(H,117,133)(H,118,135)(H,119,130)(H,120,139)(H,121,141)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t48-,49+,54-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,73-,74-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091684
(CHEMBL412257 | N-alpha-Ac-[Nle24,28,Trp30,Nva31,CH...)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C91H140N30O21/c1-7-10-20-61(113-87(141)71(46-122)120-76(130)48(4)108-50(6)124)78(132)111-63(23-15-36-103-90(97)98)81(135)118-69(41-55-44-101-47-107-55)85(139)116-67(39-52-27-31-57(126)32-28-52)83(137)112-62(21-11-8-2)80(134)119-70(42-73(93)128)86(140)117-68(40-53-43-105-59-22-13-12-19-58(53)59)84(138)110-60(17-9-3)82(136)121-74(49(5)123)88(142)115-64(24-16-37-104-91(99)100)79(133)114-65(33-34-72(92)127)77(131)109-54(18-14-35-102-89(95)96)45-106-66(75(94)129)38-51-25-29-56(125)30-26-51/h12-13,19,22,25-32,43-44,47-49,54,60-71,74,105-106,122-123,125-126H,7-11,14-18,20-21,23-24,33-42,45-46H2,1-6H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,107)(H,108,124)(H,109,131)(H,110,138)(H,111,132)(H,112,137)(H,113,141)(H,114,133)(H,115,142)(H,116,139)(H,117,140)(H,118,135)(H,119,134)(H,120,130)(H,121,136)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t48-,49+,54-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,74-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50005530
(CHEMBL267633 | D-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-G...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C190H287N55O57/c1-16-94(9)149(180(296)235-129(81-141(194)255)169(285)227-124(74-93(7)8)172(288)240-150(95(10)17-2)181(297)241-151(100(15)248)182(298)222-116(32-23-67-209-190(203)204)156(272)221-118(57-60-140(193)254)161(277)219-114(30-21-65-207-188(199)200)157(273)224-121(152(196)268)76-102-39-49-108(250)50-40-102)239-173(289)127(79-105-45-55-111(253)56-46-105)230-168(284)128(80-106-86-205-90-211-106)231-159(275)115(31-22-66-208-189(201)202)220-165(281)123(73-92(5)6)225-155(271)97(12)213-174(290)134(88-246)237-167(283)126(78-104-43-53-110(252)54-44-104)229-166(282)125(77-103-41-51-109(251)52-42-103)228-158(274)113(29-20-64-206-187(197)198)217-153(269)96(11)212-163(279)122(72-91(3)4)226-170(286)131(84-147(264)265)233-162(278)119(59-62-145(260)261)218-154(270)98(13)214-177(293)137-34-25-68-242(137)183(299)99(14)215-164(280)130(83-146(262)263)232-160(276)117(58-61-144(258)259)216-143(257)87-210-176(292)136-33-24-70-244(136)186(302)133(82-142(195)256)236-171(287)132(85-148(266)267)234-178(294)139-36-27-71-245(139)185(301)120(28-18-19-63-191)223-175(291)135(89-247)238-179(295)138-35-26-69-243(138)184(300)112(192)75-101-37-47-107(249)48-38-101/h37-56,86,90-100,112-139,149-151,246-253H,16-36,57-85,87-89,191-192H2,1-15H3,(H2,193,254)(H2,194,255)(H2,195,256)(H2,196,268)(H,205,211)(H,210,292)(H,212,279)(H,213,290)(H,214,293)(H,215,280)(H,216,257)(H,217,269)(H,218,270)(H,219,277)(H,220,281)(H,221,272)(H,222,298)(H,223,291)(H,224,273)(H,225,271)(H,226,286)(H,227,285)(H,228,274)(H,229,282)(H,230,284)(H,231,275)(H,232,276)(H,233,278)(H,234,294)(H,235,296)(H,236,287)(H,237,283)(H,238,295)(H,239,289)(H,240,288)(H,241,297)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,266,267)(H4,197,198,206)(H4,199,200,207)(H4,201,202,208)(H4,203,204,209)/t94-,95-,96-,97-,98-,99-,100+,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,149-,150-,151-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091669
(CHEMBL438923 | N-alpha-Ac-[CH2-NH28-29]PYY(22-36)-...)Show SMILES CC(C)C[C@@H](CN[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O Show InChI InChI=1S/C86H141N29O21/c1-42(2)31-52(103-77(130)63(35-50-20-24-54(120)25-21-50)111-79(132)64(36-51-38-96-41-101-51)112-74(127)56(16-13-29-98-85(92)93)105-78(131)61(32-43(3)4)110-81(134)65(40-116)113-71(124)46(9)102-48(11)118)39-100-60(37-67(88)122)76(129)109-62(33-44(5)6)80(133)114-68(45(7)8)82(135)115-69(47(10)117)83(136)107-57(17-14-30-99-86(94)95)72(125)106-58(26-27-66(87)121)75(128)104-55(15-12-28-97-84(90)91)73(126)108-59(70(89)123)34-49-18-22-53(119)23-19-49/h18-25,38,41-47,52,55-65,68-69,100,116-117,119-120H,12-17,26-37,39-40H2,1-11H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,101)(H,102,118)(H,103,130)(H,104,128)(H,105,131)(H,106,125)(H,107,136)(H,108,126)(H,109,129)(H,110,134)(H,111,132)(H,112,127)(H,113,124)(H,114,133)(H,115,135)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t46-,47+,52-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,68-,69-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091679
(CHEMBL441007 | bis(24/24'){N-alpha-Ac-[Cys24]PYY(2...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C166H264N58O44S2/c1-77(2)57-109(143(251)215-117(67-125(169)237)149(257)209-111(59-79(5)6)151(259)221-127(81(9)10)157(265)223-129(85(15)227)159(267)203-103(29-23-55-191-165(181)182)135(243)201-105(47-49-123(167)235)141(249)197-99(25-19-51-187-161(173)174)137(245)205-107(131(171)239)61-89-31-39-95(231)40-32-89)207-145(253)113(63-91-35-43-97(233)44-36-91)211-147(255)115(65-93-69-185-75-193-93)213-139(247)101(27-21-53-189-163(177)178)199-155(263)121(219-153(261)119(71-225)217-133(241)83(13)195-87(17)229)73-269-270-74-122(220-154(262)120(72-226)218-134(242)84(14)196-88(18)230)156(264)200-102(28-22-54-190-164(179)180)140(248)214-116(66-94-70-186-76-194-94)148(256)212-114(64-92-37-45-98(234)46-38-92)146(254)208-110(58-78(3)4)144(252)216-118(68-126(170)238)150(258)210-112(60-80(7)8)152(260)222-128(82(11)12)158(266)224-130(86(16)228)160(268)204-104(30-24-56-192-166(183)184)136(244)202-106(48-50-124(168)236)142(250)198-100(26-20-52-188-162(175)176)138(246)206-108(132(172)240)62-90-33-41-96(232)42-34-90/h31-46,69-70,75-86,99-122,127-130,225-228,231-234H,19-30,47-68,71-74H2,1-18H3,(H2,167,235)(H2,168,236)(H2,169,237)(H2,170,238)(H2,171,239)(H2,172,240)(H,185,193)(H,186,194)(H,195,229)(H,196,230)(H,197,249)(H,198,250)(H,199,263)(H,200,264)(H,201,243)(H,202,244)(H,203,267)(H,204,268)(H,205,245)(H,206,246)(H,207,253)(H,208,254)(H,209,257)(H,210,258)(H,211,255)(H,212,256)(H,213,247)(H,214,248)(H,215,251)(H,216,252)(H,217,241)(H,218,242)(H,219,261)(H,220,262)(H,221,259)(H,222,260)(H,223,265)(H,224,266)(H4,173,174,187)(H4,175,176,188)(H4,177,178,189)(H4,179,180,190)(H4,181,182,191)(H4,183,184,192)/t83-,84-,85+,86+,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122+,127-,128-,129-,130-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091651
(CHEMBL411200 | N-alpha-Ac-[Nle24,28,Trp30,Nva31]PY...)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C91H138N30O22/c1-7-10-19-59(112-87(142)70(45-122)120-75(130)47(4)107-49(6)124)76(131)109-62(23-15-36-103-90(97)98)80(135)118-68(41-53-44-101-46-106-53)85(140)116-66(39-51-27-31-55(126)32-28-51)83(138)111-60(20-11-8-2)79(134)119-69(42-72(93)128)86(141)117-67(40-52-43-105-57-21-13-12-18-56(52)57)84(139)108-58(17-9-3)82(137)121-73(48(5)123)88(143)114-63(24-16-37-104-91(99)100)77(132)113-64(33-34-71(92)127)81(136)110-61(22-14-35-102-89(95)96)78(133)115-65(74(94)129)38-50-25-29-54(125)30-26-50/h12-13,18,21,25-32,43-44,46-48,58-70,73,105,122-123,125-126H,7-11,14-17,19-20,22-24,33-42,45H2,1-6H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,106)(H,107,124)(H,108,139)(H,109,131)(H,110,136)(H,111,138)(H,112,142)(H,113,132)(H,114,143)(H,115,133)(H,116,140)(H,117,141)(H,118,135)(H,119,134)(H,120,130)(H,121,137)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t47-,48+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,73-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091653
(CHEMBL266021 | N-alpha-Ac-[Nle24,28,30,Nva31]PYY(2...)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C86H139N29O22/c1-8-12-19-54(71(125)102-53(18-11-4)78(132)115-68(46(6)117)83(137)109-59(24-17-37-99-86(94)95)73(127)108-60(33-34-66(87)121)77(131)104-57(22-15-35-97-84(90)91)74(128)110-61(69(89)123)38-48-25-29-51(119)30-26-48)106-81(135)64(41-67(88)122)113-75(129)56(21-14-10-3)105-79(133)62(39-49-27-31-52(120)32-28-49)111-80(134)63(40-50-42-96-44-100-50)112-76(130)58(23-16-36-98-85(92)93)103-72(126)55(20-13-9-2)107-82(136)65(43-116)114-70(124)45(5)101-47(7)118/h25-32,42,44-46,53-65,68,116-117,119-120H,8-24,33-41,43H2,1-7H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,100)(H,101,118)(H,102,125)(H,103,126)(H,104,131)(H,105,133)(H,106,135)(H,107,136)(H,108,127)(H,109,137)(H,110,128)(H,111,134)(H,112,130)(H,113,129)(H,114,124)(H,115,132)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t45-,46+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,68-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.590 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091661
(CHEMBL410938 | N-alpha-Ac-[Trp28]PYY(22-36)-NH2(N-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C91H138N30O22/c1-44(2)33-63(114-86(141)69(42-122)119-75(130)47(7)107-49(9)124)80(135)109-59(18-13-31-103-90(97)98)78(133)117-67(38-53-41-101-43-106-53)83(138)115-65(36-51-22-26-55(126)27-23-51)81(136)116-66(37-52-40-105-57-16-11-10-15-56(52)57)82(137)118-68(39-71(93)128)84(139)113-64(34-45(3)4)85(140)120-72(46(5)6)87(142)121-73(48(8)123)88(143)111-60(19-14-32-104-91(99)100)76(131)110-61(28-29-70(92)127)79(134)108-58(17-12-30-102-89(95)96)77(132)112-62(74(94)129)35-50-20-24-54(125)25-21-50/h10-11,15-16,20-27,40-41,43-48,58-69,72-73,105,122-123,125-126H,12-14,17-19,28-39,42H2,1-9H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,106)(H,107,124)(H,108,134)(H,109,135)(H,110,131)(H,111,143)(H,112,132)(H,113,139)(H,114,141)(H,115,138)(H,116,136)(H,117,133)(H,118,137)(H,119,130)(H,120,140)(H,121,142)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t47-,48+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,72-,73-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Tested for the affinity for intestinal PYY from rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091674
(CHEMBL412698 | N-alpha-Ac-[D-Trp30]PYY(22-36)-NH2(...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C91H138N30O22/c1-44(2)33-63(114-86(141)69(42-122)119-75(130)47(7)107-49(9)124)80(135)109-59(18-13-31-103-90(97)98)78(133)117-67(38-53-41-101-43-106-53)83(138)115-65(36-51-22-26-55(126)27-23-51)82(137)113-64(34-45(3)4)81(136)118-68(39-71(93)128)84(139)116-66(37-52-40-105-57-16-11-10-15-56(52)57)85(140)120-72(46(5)6)87(142)121-73(48(8)123)88(143)111-60(19-14-32-104-91(99)100)76(131)110-61(28-29-70(92)127)79(134)108-58(17-12-30-102-89(95)96)77(132)112-62(74(94)129)35-50-20-24-54(125)25-21-50/h10-11,15-16,20-27,40-41,43-48,58-69,72-73,105,122-123,125-126H,12-14,17-19,28-39,42H2,1-9H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,106)(H,107,124)(H,108,134)(H,109,135)(H,110,131)(H,111,143)(H,112,132)(H,113,137)(H,114,141)(H,115,138)(H,116,139)(H,117,133)(H,118,136)(H,119,130)(H,120,140)(H,121,142)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t47-,48+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,72-,73-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091679
(CHEMBL441007 | bis(24/24'){N-alpha-Ac-[Cys24]PYY(2...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C166H264N58O44S2/c1-77(2)57-109(143(251)215-117(67-125(169)237)149(257)209-111(59-79(5)6)151(259)221-127(81(9)10)157(265)223-129(85(15)227)159(267)203-103(29-23-55-191-165(181)182)135(243)201-105(47-49-123(167)235)141(249)197-99(25-19-51-187-161(173)174)137(245)205-107(131(171)239)61-89-31-39-95(231)40-32-89)207-145(253)113(63-91-35-43-97(233)44-36-91)211-147(255)115(65-93-69-185-75-193-93)213-139(247)101(27-21-53-189-163(177)178)199-155(263)121(219-153(261)119(71-225)217-133(241)83(13)195-87(17)229)73-269-270-74-122(220-154(262)120(72-226)218-134(242)84(14)196-88(18)230)156(264)200-102(28-22-54-190-164(179)180)140(248)214-116(66-94-70-186-76-194-94)148(256)212-114(64-92-37-45-98(234)46-38-92)146(254)208-110(58-78(3)4)144(252)216-118(68-126(170)238)150(258)210-112(60-80(7)8)152(260)222-128(82(11)12)158(266)224-130(86(16)228)160(268)204-104(30-24-56-192-166(183)184)136(244)202-106(48-50-124(168)236)142(250)198-100(26-20-52-188-162(175)176)138(246)206-108(132(172)240)62-90-33-41-96(232)42-34-90/h31-46,69-70,75-86,99-122,127-130,225-228,231-234H,19-30,47-68,71-74H2,1-18H3,(H2,167,235)(H2,168,236)(H2,169,237)(H2,170,238)(H2,171,239)(H2,172,240)(H,185,193)(H,186,194)(H,195,229)(H,196,230)(H,197,249)(H,198,250)(H,199,263)(H,200,264)(H,201,243)(H,202,244)(H,203,267)(H,204,268)(H,205,245)(H,206,246)(H,207,253)(H,208,254)(H,209,257)(H,210,258)(H,211,255)(H,212,256)(H,213,247)(H,214,248)(H,215,251)(H,216,252)(H,217,241)(H,218,242)(H,219,261)(H,220,262)(H,221,259)(H,222,260)(H,223,265)(H,224,266)(H4,173,174,187)(H4,175,176,188)(H4,177,178,189)(H4,179,180,190)(H4,181,182,191)(H4,183,184,192)/t83-,84-,85+,86+,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122+,127-,128-,129-,130-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091668
(AcPYY(22-36) | CHEMBL269267 | N-alpha-Ac-PYY(22-36...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C86H139N29O22/c1-41(2)31-58(109-81(135)64(39-116)113-70(124)45(9)101-47(11)118)75(129)103-54(16-13-29-98-85(92)93)73(127)111-62(36-50-38-96-40-100-50)78(132)110-61(35-49-20-24-52(120)25-21-49)77(131)107-59(32-42(3)4)76(130)112-63(37-66(88)122)79(133)108-60(33-43(5)6)80(134)114-67(44(7)8)82(136)115-68(46(10)117)83(137)105-55(17-14-30-99-86(94)95)71(125)104-56(26-27-65(87)121)74(128)102-53(15-12-28-97-84(90)91)72(126)106-57(69(89)123)34-48-18-22-51(119)23-19-48/h18-25,38,40-46,53-64,67-68,116-117,119-120H,12-17,26-37,39H2,1-11H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,100)(H,101,118)(H,102,128)(H,103,129)(H,104,125)(H,105,137)(H,106,126)(H,107,131)(H,108,133)(H,109,135)(H,110,132)(H,111,127)(H,112,130)(H,113,124)(H,114,134)(H,115,136)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t45-,46+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,67-,68-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.910 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091674
(CHEMBL412698 | N-alpha-Ac-[D-Trp30]PYY(22-36)-NH2(...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C91H138N30O22/c1-44(2)33-63(114-86(141)69(42-122)119-75(130)47(7)107-49(9)124)80(135)109-59(18-13-31-103-90(97)98)78(133)117-67(38-53-41-101-43-106-53)83(138)115-65(36-51-22-26-55(126)27-23-51)82(137)113-64(34-45(3)4)81(136)118-68(39-71(93)128)84(139)116-66(37-52-40-105-57-16-11-10-15-56(52)57)85(140)120-72(46(5)6)87(142)121-73(48(8)123)88(143)111-60(19-14-32-104-91(99)100)76(131)110-61(28-29-70(92)127)79(134)108-58(17-12-30-102-89(95)96)77(132)112-62(74(94)129)35-50-20-24-54(125)25-21-50/h10-11,15-16,20-27,40-41,43-48,58-69,72-73,105,122-123,125-126H,12-14,17-19,28-39,42H2,1-9H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,106)(H,107,124)(H,108,134)(H,109,135)(H,110,131)(H,111,143)(H,112,132)(H,113,137)(H,114,141)(H,115,138)(H,116,139)(H,117,133)(H,118,136)(H,119,130)(H,120,140)(H,121,142)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t47-,48+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,72-,73-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.980 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091650
(Ala-Ser-Leu-Arg-His-Thi-Leu-Asn-Leu-Val-Thr-Arg-Gl...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccsc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C84H137N29O21S/c1-40(2)29-56(107-79(132)62(37-114)111-68(121)44(9)99-46(11)116)73(126)101-52(16-13-26-96-83(90)91)71(124)109-60(34-49-36-94-39-98-49)76(129)108-59(33-48-24-28-135-38-48)75(128)105-57(30-41(3)4)74(127)110-61(35-64(86)119)77(130)106-58(31-42(5)6)78(131)112-65(43(7)8)80(133)113-66(45(10)115)81(134)103-53(17-14-27-97-84(92)93)69(122)102-54(22-23-63(85)118)72(125)100-51(15-12-25-95-82(88)89)70(123)104-55(67(87)120)32-47-18-20-50(117)21-19-47/h18-21,24,28,36,38-45,51-62,65-66,114-115,117H,12-17,22-23,25-27,29-35,37H2,1-11H3,(H2,85,118)(H2,86,119)(H2,87,120)(H,94,98)(H,99,116)(H,100,125)(H,101,126)(H,102,122)(H,103,134)(H,104,123)(H,105,128)(H,106,130)(H,107,132)(H,108,129)(H,109,124)(H,110,127)(H,111,121)(H,112,131)(H,113,133)(H4,88,89,95)(H4,90,91,96)(H4,92,93,97)/t44-,45+,51-,52-,53-,54-,55-,56-,57-,58-,59+,60-,61-,62-,65-,66-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091659
(CHEMBL384306 | N-alpha-Ac-[Trp27,CH2-NH-35-36]PYY(...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C88H142N30O20/c1-43(2)31-61(112-83(136)67(41-119)116-73(126)47(9)105-49(11)121)77(130)107-57(20-15-29-100-87(94)95)76(129)114-65(36-53-39-98-42-104-53)80(133)113-64(35-51-38-102-56-19-13-12-18-55(51)56)79(132)110-62(32-44(3)4)78(131)115-66(37-69(90)124)81(134)111-63(33-45(5)6)82(135)117-70(46(7)8)84(137)118-71(48(10)120)85(138)109-58(21-16-30-101-88(96)97)75(128)108-59(26-27-68(89)123)74(127)106-52(17-14-28-99-86(92)93)40-103-60(72(91)125)34-50-22-24-54(122)25-23-50/h12-13,18-19,22-25,38-39,42-48,52,57-67,70-71,102-103,119-120,122H,14-17,20-21,26-37,40-41H2,1-11H3,(H2,89,123)(H2,90,124)(H2,91,125)(H,98,104)(H,105,121)(H,106,127)(H,107,130)(H,108,128)(H,109,138)(H,110,132)(H,111,134)(H,112,136)(H,113,133)(H,114,129)(H,115,131)(H,116,126)(H,117,135)(H,118,137)(H4,92,93,99)(H4,94,95,100)(H4,96,97,101)/t47-,48+,52-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,70-,71-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.05 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091685
(CHEMBL411637 | N-alpha-Ac-[Trp28,30]PYY(22-36)-NH2...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C96H137N31O22/c1-47(2)35-68(119-91(147)74(45-128)125-80(136)49(5)113-51(7)130)85(141)115-64(20-13-33-108-95(102)103)83(139)123-72(40-56-44-106-46-112-56)88(144)120-69(37-53-24-28-58(132)29-25-53)86(142)121-70(38-54-42-110-61-17-10-8-15-59(54)61)87(143)124-73(41-76(98)134)89(145)122-71(39-55-43-111-62-18-11-9-16-60(55)62)90(146)126-77(48(3)4)92(148)127-78(50(6)129)93(149)117-65(21-14-34-109-96(104)105)81(137)116-66(30-31-75(97)133)84(140)114-63(19-12-32-107-94(100)101)82(138)118-67(79(99)135)36-52-22-26-57(131)27-23-52/h8-11,15-18,22-29,42-44,46-50,63-74,77-78,110-111,128-129,131-132H,12-14,19-21,30-41,45H2,1-7H3,(H2,97,133)(H2,98,134)(H2,99,135)(H,106,112)(H,113,130)(H,114,140)(H,115,141)(H,116,137)(H,117,149)(H,118,138)(H,119,147)(H,120,144)(H,121,142)(H,122,145)(H,123,139)(H,124,143)(H,125,136)(H,126,146)(H,127,148)(H4,100,101,107)(H4,102,103,108)(H4,104,105,109)/t49-,50+,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,77-,78-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.07 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091662
(CHEMBL410792 | N-alpha-Ac-[Nal30]PYY(22-36)-NH2(N-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C93H139N29O22/c1-46(2)36-65(115-88(142)71(44-123)120-77(131)49(7)108-51(9)125)82(136)110-61(21-14-34-105-92(99)100)80(134)118-69(41-56-43-103-45-107-56)85(139)116-67(39-53-25-29-58(127)30-26-53)84(138)114-66(37-47(3)4)83(137)119-70(42-73(95)129)86(140)117-68(40-55-18-12-17-54-16-10-11-19-59(54)55)87(141)121-74(48(5)6)89(143)122-75(50(8)124)90(144)112-62(22-15-35-106-93(101)102)78(132)111-63(31-32-72(94)128)81(135)109-60(20-13-33-104-91(97)98)79(133)113-64(76(96)130)38-52-23-27-57(126)28-24-52/h10-12,16-19,23-30,43,45-50,60-71,74-75,123-124,126-127H,13-15,20-22,31-42,44H2,1-9H3,(H2,94,128)(H2,95,129)(H2,96,130)(H,103,107)(H,108,125)(H,109,135)(H,110,136)(H,111,132)(H,112,144)(H,113,133)(H,114,138)(H,115,142)(H,116,139)(H,117,140)(H,118,134)(H,119,137)(H,120,131)(H,121,141)(H,122,143)(H4,97,98,104)(H4,99,100,105)(H4,101,102,106)/t49-,50+,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,74-,75-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.09 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091659
(CHEMBL384306 | N-alpha-Ac-[Trp27,CH2-NH-35-36]PYY(...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C88H142N30O20/c1-43(2)31-61(112-83(136)67(41-119)116-73(126)47(9)105-49(11)121)77(130)107-57(20-15-29-100-87(94)95)76(129)114-65(36-53-39-98-42-104-53)80(133)113-64(35-51-38-102-56-19-13-12-18-55(51)56)79(132)110-62(32-44(3)4)78(131)115-66(37-69(90)124)81(134)111-63(33-45(5)6)82(135)117-70(46(7)8)84(137)118-71(48(10)120)85(138)109-58(21-16-30-101-88(96)97)75(128)108-59(26-27-68(89)123)74(127)106-52(17-14-28-99-86(92)93)40-103-60(72(91)125)34-50-22-24-54(122)25-23-50/h12-13,18-19,22-25,38-39,42-48,52,57-67,70-71,102-103,119-120,122H,14-17,20-21,26-37,40-41H2,1-11H3,(H2,89,123)(H2,90,124)(H2,91,125)(H,98,104)(H,105,121)(H,106,127)(H,107,130)(H,108,128)(H,109,138)(H,110,132)(H,111,134)(H,112,136)(H,113,133)(H,114,129)(H,115,131)(H,116,126)(H,117,135)(H,118,137)(H4,92,93,99)(H4,94,95,100)(H4,96,97,101)/t47-,48+,52-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,70-,71-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.12 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091676
(CHEMBL429905 | N-alpha-Ac-[Phe27,36]PYY(22-36)-NH2...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O Show InChI InChI=1S/C86H139N29O20/c1-43(2)33-58(109-81(133)64(41-116)113-70(122)47(9)101-49(11)118)75(127)103-54(26-19-31-98-85(92)93)73(125)111-62(38-52-40-96-42-100-52)78(130)110-61(37-51-23-16-13-17-24-51)77(129)107-59(34-44(3)4)76(128)112-63(39-66(88)120)79(131)108-60(35-45(5)6)80(132)114-67(46(7)8)82(134)115-68(48(10)117)83(135)105-55(27-20-32-99-86(94)95)71(123)104-56(28-29-65(87)119)74(126)102-53(25-18-30-97-84(90)91)72(124)106-57(69(89)121)36-50-21-14-12-15-22-50/h12-17,21-24,40,42-48,53-64,67-68,116-117H,18-20,25-39,41H2,1-11H3,(H2,87,119)(H2,88,120)(H2,89,121)(H,96,100)(H,101,118)(H,102,126)(H,103,127)(H,104,123)(H,105,135)(H,106,124)(H,107,129)(H,108,131)(H,109,133)(H,110,130)(H,111,125)(H,112,128)(H,113,122)(H,114,132)(H,115,134)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t47-,48+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,67-,68-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.16 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091668
(AcPYY(22-36) | CHEMBL269267 | N-alpha-Ac-PYY(22-36...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C86H139N29O22/c1-41(2)31-58(109-81(135)64(39-116)113-70(124)45(9)101-47(11)118)75(129)103-54(16-13-29-98-85(92)93)73(127)111-62(36-50-38-96-40-100-50)78(132)110-61(35-49-20-24-52(120)25-21-49)77(131)107-59(32-42(3)4)76(130)112-63(37-66(88)122)79(133)108-60(33-43(5)6)80(134)114-67(44(7)8)82(136)115-68(46(10)117)83(137)105-55(17-14-30-99-86(94)95)71(125)104-56(26-27-65(87)121)74(128)102-53(15-12-28-97-84(90)91)72(126)106-57(69(89)123)34-48-18-22-51(119)23-19-48/h18-25,38,40-46,53-64,67-68,116-117,119-120H,12-17,26-37,39H2,1-11H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,100)(H,101,118)(H,102,128)(H,103,129)(H,104,125)(H,105,137)(H,106,126)(H,107,131)(H,108,133)(H,109,135)(H,110,132)(H,111,127)(H,112,130)(H,113,124)(H,114,134)(H,115,136)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t45-,46+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,67-,68-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091672
(CHEMBL412704 | N-alpha-Ac-[CH2-NH35-36]PYY(22-36)-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C86H141N29O21/c1-42(2)31-59(109-81(134)65(40-116)113-71(124)46(9)102-48(11)118)75(128)104-55(16-13-29-98-85(92)93)74(127)111-63(36-52-38-96-41-101-52)78(131)110-62(35-50-20-24-54(120)25-21-50)77(130)107-60(32-43(3)4)76(129)112-64(37-67(88)122)79(132)108-61(33-44(5)6)80(133)114-68(45(7)8)82(135)115-69(47(10)117)83(136)106-56(17-14-30-99-86(94)95)73(126)105-57(26-27-66(87)121)72(125)103-51(15-12-28-97-84(90)91)39-100-58(70(89)123)34-49-18-22-53(119)23-19-49/h18-25,38,41-47,51,55-65,68-69,100,116-117,119-120H,12-17,26-37,39-40H2,1-11H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,101)(H,102,118)(H,103,125)(H,104,128)(H,105,126)(H,106,136)(H,107,130)(H,108,132)(H,109,134)(H,110,131)(H,111,127)(H,112,129)(H,113,124)(H,114,133)(H,115,135)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t46-,47+,51-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,68-,69-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.32 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091663
(CHEMBL214707 | N-alpha-Ac-[Trp30,CH2-NH-35-36]PYY(...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C91H140N30O21/c1-45(2)33-64(114-86(140)70(43-122)119-76(130)48(7)108-50(9)124)80(134)110-60(18-13-31-103-90(97)98)79(133)117-68(38-55-41-101-44-107-55)83(137)115-66(36-52-22-26-57(126)27-23-52)82(136)113-65(34-46(3)4)81(135)118-69(39-72(93)128)84(138)116-67(37-53-40-105-59-17-11-10-16-58(53)59)85(139)120-73(47(5)6)87(141)121-74(49(8)123)88(142)112-61(19-14-32-104-91(99)100)78(132)111-62(28-29-71(92)127)77(131)109-54(15-12-30-102-89(95)96)42-106-63(75(94)129)35-51-20-24-56(125)25-21-51/h10-11,16-17,20-27,40-41,44-49,54,60-70,73-74,105-106,122-123,125-126H,12-15,18-19,28-39,42-43H2,1-9H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,107)(H,108,124)(H,109,131)(H,110,134)(H,111,132)(H,112,142)(H,113,136)(H,114,140)(H,115,137)(H,116,138)(H,117,133)(H,118,135)(H,119,130)(H,120,139)(H,121,141)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t48-,49+,54-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,73-,74-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.39 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091684
(CHEMBL412257 | N-alpha-Ac-[Nle24,28,Trp30,Nva31,CH...)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C91H140N30O21/c1-7-10-20-61(113-87(141)71(46-122)120-76(130)48(4)108-50(6)124)78(132)111-63(23-15-36-103-90(97)98)81(135)118-69(41-55-44-101-47-107-55)85(139)116-67(39-52-27-31-57(126)32-28-52)83(137)112-62(21-11-8-2)80(134)119-70(42-73(93)128)86(140)117-68(40-53-43-105-59-22-13-12-19-58(53)59)84(138)110-60(17-9-3)82(136)121-74(49(5)123)88(142)115-64(24-16-37-104-91(99)100)79(133)114-65(33-34-72(92)127)77(131)109-54(18-14-35-102-89(95)96)45-106-66(75(94)129)38-51-25-29-56(125)30-26-51/h12-13,19,22,25-32,43-44,47-49,54,60-71,74,105-106,122-123,125-126H,7-11,14-18,20-21,23-24,33-42,45-46H2,1-6H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,107)(H,108,124)(H,109,131)(H,110,138)(H,111,132)(H,112,137)(H,113,141)(H,114,133)(H,115,142)(H,116,139)(H,117,140)(H,118,135)(H,119,134)(H,120,130)(H,121,136)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t48-,49+,54-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,74-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.75 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091666
(CHEMBL413612 | N-alpha-Ac-[Phe27]PYY(22-36)-NH2(N-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C86H139N29O21/c1-42(2)32-58(109-81(134)64(40-116)113-70(123)46(9)101-48(11)118)75(128)103-54(21-16-30-98-85(92)93)73(126)111-62(37-51-39-96-41-100-51)78(131)110-61(36-49-18-13-12-14-19-49)77(130)107-59(33-43(3)4)76(129)112-63(38-66(88)121)79(132)108-60(34-44(5)6)80(133)114-67(45(7)8)82(135)115-68(47(10)117)83(136)105-55(22-17-31-99-86(94)95)71(124)104-56(27-28-65(87)120)74(127)102-53(20-15-29-97-84(90)91)72(125)106-57(69(89)122)35-50-23-25-52(119)26-24-50/h12-14,18-19,23-26,39,41-47,53-64,67-68,116-117,119H,15-17,20-22,27-38,40H2,1-11H3,(H2,87,120)(H2,88,121)(H2,89,122)(H,96,100)(H,101,118)(H,102,127)(H,103,128)(H,104,124)(H,105,136)(H,106,125)(H,107,130)(H,108,132)(H,109,134)(H,110,131)(H,111,126)(H,112,129)(H,113,123)(H,114,133)(H,115,135)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t46-,47+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,67-,68-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.83 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50005530
(CHEMBL267633 | D-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-G...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C190H287N55O57/c1-16-94(9)149(180(296)235-129(81-141(194)255)169(285)227-124(74-93(7)8)172(288)240-150(95(10)17-2)181(297)241-151(100(15)248)182(298)222-116(32-23-67-209-190(203)204)156(272)221-118(57-60-140(193)254)161(277)219-114(30-21-65-207-188(199)200)157(273)224-121(152(196)268)76-102-39-49-108(250)50-40-102)239-173(289)127(79-105-45-55-111(253)56-46-105)230-168(284)128(80-106-86-205-90-211-106)231-159(275)115(31-22-66-208-189(201)202)220-165(281)123(73-92(5)6)225-155(271)97(12)213-174(290)134(88-246)237-167(283)126(78-104-43-53-110(252)54-44-104)229-166(282)125(77-103-41-51-109(251)52-42-103)228-158(274)113(29-20-64-206-187(197)198)217-153(269)96(11)212-163(279)122(72-91(3)4)226-170(286)131(84-147(264)265)233-162(278)119(59-62-145(260)261)218-154(270)98(13)214-177(293)137-34-25-68-242(137)183(299)99(14)215-164(280)130(83-146(262)263)232-160(276)117(58-61-144(258)259)216-143(257)87-210-176(292)136-33-24-70-244(136)186(302)133(82-142(195)256)236-171(287)132(85-148(266)267)234-178(294)139-36-27-71-245(139)185(301)120(28-18-19-63-191)223-175(291)135(89-247)238-179(295)138-35-26-69-243(138)184(300)112(192)75-101-37-47-107(249)48-38-101/h37-56,86,90-100,112-139,149-151,246-253H,16-36,57-85,87-89,191-192H2,1-15H3,(H2,193,254)(H2,194,255)(H2,195,256)(H2,196,268)(H,205,211)(H,210,292)(H,212,279)(H,213,290)(H,214,293)(H,215,280)(H,216,257)(H,217,269)(H,218,270)(H,219,277)(H,220,281)(H,221,272)(H,222,298)(H,223,291)(H,224,273)(H,225,271)(H,226,286)(H,227,285)(H,228,274)(H,229,282)(H,230,284)(H,231,275)(H,232,276)(H,233,278)(H,234,294)(H,235,296)(H,236,287)(H,237,283)(H,238,295)(H,239,289)(H,240,288)(H,241,297)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,266,267)(H4,197,198,206)(H4,199,200,207)(H4,201,202,208)(H4,203,204,209)/t94-,95-,96-,97-,98-,99-,100+,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,149-,150-,151-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091661
(CHEMBL410938 | N-alpha-Ac-[Trp28]PYY(22-36)-NH2(N-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C91H138N30O22/c1-44(2)33-63(114-86(141)69(42-122)119-75(130)47(7)107-49(9)124)80(135)109-59(18-13-31-103-90(97)98)78(133)117-67(38-53-41-101-43-106-53)83(138)115-65(36-51-22-26-55(126)27-23-51)81(136)116-66(37-52-40-105-57-16-11-10-15-56(52)57)82(137)118-68(39-71(93)128)84(139)113-64(34-45(3)4)85(140)120-72(46(5)6)87(142)121-73(48(8)123)88(143)111-60(19-14-32-104-91(99)100)76(131)110-61(28-29-70(92)127)79(134)108-58(17-12-30-102-89(95)96)77(132)112-62(74(94)129)35-50-20-24-54(125)25-21-50/h10-11,15-16,20-27,40-41,43-48,58-69,72-73,105,122-123,125-126H,12-14,17-19,28-39,42H2,1-9H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,106)(H,107,124)(H,108,134)(H,109,135)(H,110,131)(H,111,143)(H,112,132)(H,113,139)(H,114,141)(H,115,138)(H,116,136)(H,117,133)(H,118,137)(H,119,130)(H,120,140)(H,121,142)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t47-,48+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,72-,73-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.08 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091670
(CHEMBL428320 | N-alpha-Ac-[Trp27]PYY(22-36)-NH2(N-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C88H140N30O21/c1-42(2)31-60(112-83(137)66(40-119)116-72(126)46(9)104-48(11)121)77(131)106-56(20-15-29-100-87(94)95)75(129)114-64(36-51-39-98-41-103-51)80(134)113-63(35-50-38-102-54-18-13-12-17-53(50)54)79(133)110-61(32-43(3)4)78(132)115-65(37-68(90)124)81(135)111-62(33-44(5)6)82(136)117-69(45(7)8)84(138)118-70(47(10)120)85(139)108-57(21-16-30-101-88(96)97)73(127)107-58(26-27-67(89)123)76(130)105-55(19-14-28-99-86(92)93)74(128)109-59(71(91)125)34-49-22-24-52(122)25-23-49/h12-13,17-18,22-25,38-39,41-47,55-66,69-70,102,119-120,122H,14-16,19-21,26-37,40H2,1-11H3,(H2,89,123)(H2,90,124)(H2,91,125)(H,98,103)(H,104,121)(H,105,130)(H,106,131)(H,107,127)(H,108,139)(H,109,128)(H,110,133)(H,111,135)(H,112,137)(H,113,134)(H,114,129)(H,115,132)(H,116,126)(H,117,136)(H,118,138)(H4,92,93,99)(H4,94,95,100)(H4,96,97,101)/t46-,47+,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,69-,70-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.09 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091683
(CHEMBL438096 | N-alpha-Ac-[Trp24]PYY(22-36)-NH2(N-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C91H138N30O22/c1-44(2)33-63(113-81(136)65(36-51-22-26-55(126)27-23-51)115-83(138)67(38-53-41-101-43-106-53)117-78(133)59(18-13-31-103-90(97)98)109-82(137)66(37-52-40-105-57-16-11-10-15-56(52)57)116-86(141)69(42-122)119-75(130)47(7)107-49(9)124)80(135)118-68(39-71(93)128)84(139)114-64(34-45(3)4)85(140)120-72(46(5)6)87(142)121-73(48(8)123)88(143)111-60(19-14-32-104-91(99)100)76(131)110-61(28-29-70(92)127)79(134)108-58(17-12-30-102-89(95)96)77(132)112-62(74(94)129)35-50-20-24-54(125)25-21-50/h10-11,15-16,20-27,40-41,43-48,58-69,72-73,105,122-123,125-126H,12-14,17-19,28-39,42H2,1-9H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,106)(H,107,124)(H,108,134)(H,109,137)(H,110,131)(H,111,143)(H,112,132)(H,113,136)(H,114,139)(H,115,138)(H,116,141)(H,117,133)(H,118,135)(H,119,130)(H,120,140)(H,121,142)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t47-,48+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,72-,73-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Tested for the affinity for intestinal PYY from rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091666
(CHEMBL413612 | N-alpha-Ac-[Phe27]PYY(22-36)-NH2(N-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C86H139N29O21/c1-42(2)32-58(109-81(134)64(40-116)113-70(123)46(9)101-48(11)118)75(128)103-54(21-16-30-98-85(92)93)73(126)111-62(37-51-39-96-41-100-51)78(131)110-61(36-49-18-13-12-14-19-49)77(130)107-59(33-43(3)4)76(129)112-63(38-66(88)121)79(132)108-60(34-44(5)6)80(133)114-67(45(7)8)82(135)115-68(47(10)117)83(136)105-55(22-17-31-99-86(94)95)71(124)104-56(27-28-65(87)120)74(127)102-53(20-15-29-97-84(90)91)72(125)106-57(69(89)122)35-50-23-25-52(119)26-24-50/h12-14,18-19,23-26,39,41-47,53-64,67-68,116-117,119H,15-17,20-22,27-38,40H2,1-11H3,(H2,87,120)(H2,88,121)(H2,89,122)(H,96,100)(H,101,118)(H,102,127)(H,103,128)(H,104,124)(H,105,136)(H,106,125)(H,107,130)(H,108,132)(H,109,134)(H,110,131)(H,111,126)(H,112,129)(H,113,123)(H,114,133)(H,115,135)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t46-,47+,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,67-,68-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091675
(CHEMBL412378 | N-alpha-Ac-[Bip27]PYY(22-36)-NH2)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C92H143N29O21/c1-46(2)36-64(115-87(140)70(44-122)119-76(129)50(9)107-52(11)124)81(134)109-60(21-16-34-104-91(98)99)79(132)117-68(41-57-43-102-45-106-57)84(137)116-67(40-53-23-27-56(28-24-53)55-18-13-12-14-19-55)83(136)113-65(37-47(3)4)82(135)118-69(42-72(94)127)85(138)114-66(38-48(5)6)86(139)120-73(49(7)8)88(141)121-74(51(10)123)89(142)111-61(22-17-35-105-92(100)101)77(130)110-62(31-32-71(93)126)80(133)108-59(20-15-33-103-90(96)97)78(131)112-63(75(95)128)39-54-25-29-58(125)30-26-54/h12-14,18-19,23-30,43,45-51,59-70,73-74,122-123,125H,15-17,20-22,31-42,44H2,1-11H3,(H2,93,126)(H2,94,127)(H2,95,128)(H,102,106)(H,107,124)(H,108,133)(H,109,134)(H,110,130)(H,111,142)(H,112,131)(H,113,136)(H,114,138)(H,115,140)(H,116,137)(H,117,132)(H,118,135)(H,119,129)(H,120,139)(H,121,141)(H4,96,97,103)(H4,98,99,104)(H4,100,101,105)/t50-,51+,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,73-,74-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.42 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Tested for the affinity for intestinal PYY from rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091650
(Ala-Ser-Leu-Arg-His-Thi-Leu-Asn-Leu-Val-Thr-Arg-Gl...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccsc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C84H137N29O21S/c1-40(2)29-56(107-79(132)62(37-114)111-68(121)44(9)99-46(11)116)73(126)101-52(16-13-26-96-83(90)91)71(124)109-60(34-49-36-94-39-98-49)76(129)108-59(33-48-24-28-135-38-48)75(128)105-57(30-41(3)4)74(127)110-61(35-64(86)119)77(130)106-58(31-42(5)6)78(131)112-65(43(7)8)80(133)113-66(45(10)115)81(134)103-53(17-14-27-97-84(92)93)69(122)102-54(22-23-63(85)118)72(125)100-51(15-12-25-95-82(88)89)70(123)104-55(67(87)120)32-47-18-20-50(117)21-19-47/h18-21,24,28,36,38-45,51-62,65-66,114-115,117H,12-17,22-23,25-27,29-35,37H2,1-11H3,(H2,85,118)(H2,86,119)(H2,87,120)(H,94,98)(H,99,116)(H,100,125)(H,101,126)(H,102,122)(H,103,134)(H,104,123)(H,105,128)(H,106,130)(H,107,132)(H,108,129)(H,109,124)(H,110,127)(H,111,121)(H,112,131)(H,113,133)(H4,88,89,95)(H4,90,91,96)(H4,92,93,97)/t44-,45+,51-,52-,53-,54-,55-,56-,57-,58-,59+,60-,61-,62-,65-,66-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.63 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091658
(CHEMBL427594 | N-alpha-Ac-[Tyr22,Phe27]PYY(22-36)-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C92H143N29O22/c1-46(2)35-63(115-87(141)70(44-122)119-82(136)66(107-51(10)124)40-54-24-28-57(126)29-25-54)80(134)109-59(20-15-33-104-91(98)99)78(132)117-68(41-55-43-102-45-106-55)84(138)116-67(39-52-17-12-11-13-18-52)83(137)113-64(36-47(3)4)81(135)118-69(42-72(94)128)85(139)114-65(37-48(5)6)86(140)120-73(49(7)8)88(142)121-74(50(9)123)89(143)111-60(21-16-34-105-92(100)101)76(130)110-61(30-31-71(93)127)79(133)108-58(19-14-32-103-90(96)97)77(131)112-62(75(95)129)38-53-22-26-56(125)27-23-53/h11-13,17-18,22-29,43,45-50,58-70,73-74,122-123,125-126H,14-16,19-21,30-42,44H2,1-10H3,(H2,93,127)(H2,94,128)(H2,95,129)(H,102,106)(H,107,124)(H,108,133)(H,109,134)(H,110,130)(H,111,143)(H,112,131)(H,113,137)(H,114,139)(H,115,141)(H,116,138)(H,117,132)(H,118,135)(H,119,136)(H,120,140)(H,121,142)(H4,96,97,103)(H4,98,99,104)(H4,100,101,105)/t50-,58+,59+,60+,61+,62+,63+,64+,65+,66+,67+,68+,69+,70+,73+,74+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.68 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50091655
(CHEMBL438411 | [Leu31, Pro34]PYY(YPAKPEAPGEDASPEEL...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O Show InChI InChI=1S/C191H288N52O57/c1-94(2)75-125(165(277)215-116(28-18-66-204-188(195)196)158(270)231-133(85-109-88-203-93-209-109)171(283)230-132(83-107-43-53-113(251)54-44-107)169(281)224-127(77-96(5)6)167(279)232-134(86-145(194)253)172(284)225-126(76-95(3)4)166(278)226-129(79-98(9)10)173(285)238-152(103(15)247)181(293)222-124(31-21-69-207-191(201)202)185(297)242-73-24-34-142(242)178(290)218-118(30-20-68-206-190(199)200)159(271)234-136(187(299)300)84-108-45-55-114(252)56-46-108)227-175(287)137(90-244)235-154(266)99(11)210-163(275)130(81-105-39-49-111(249)50-40-105)229-170(282)131(82-106-41-51-112(250)52-42-106)228-157(269)117(29-19-67-205-189(197)198)216-174(286)138(91-245)236-168(280)128(78-97(7)8)223-162(274)121(59-63-149(259)260)217-161(273)122(60-64-150(261)262)220-180(292)144-36-26-74-243(144)186(298)139(92-246)237-155(267)100(12)211-164(276)135(87-151(263)264)233-160(272)119(57-61-147(255)256)214-146(254)89-208-176(288)140-32-22-70-239(140)182(294)102(14)213-156(268)120(58-62-148(257)258)219-179(291)143-35-25-72-241(143)184(296)123(27-16-17-65-192)221-153(265)101(13)212-177(289)141-33-23-71-240(141)183(295)115(193)80-104-37-47-110(248)48-38-104/h37-56,88,93-103,115-144,152,244-252H,16-36,57-87,89-92,192-193H2,1-15H3,(H2,194,253)(H,203,209)(H,208,288)(H,210,275)(H,211,276)(H,212,289)(H,213,268)(H,214,254)(H,215,277)(H,216,286)(H,217,273)(H,218,290)(H,219,291)(H,220,292)(H,221,265)(H,222,293)(H,223,274)(H,224,281)(H,225,284)(H,226,278)(H,227,287)(H,228,269)(H,229,282)(H,230,283)(H,231,270)(H,232,279)(H,233,272)(H,234,271)(H,235,266)(H,236,280)(H,237,267)(H,238,285)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,299,300)(H4,195,196,204)(H4,197,198,205)(H4,199,200,206)(H4,201,202,207)/t99-,100-,101-,102-,103+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,152-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.69 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091667
(CHEMBL428292 | N-alpha-Ac-[CH2-NH24-25]PYY(22-36)-...)Show SMILES CC(C)C[C@@H](CN[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O Show InChI InChI=1S/C86H141N29O21/c1-42(2)31-52(103-81(134)65(40-116)113-71(124)46(9)102-48(11)118)39-100-55(15-12-28-97-84(90)91)72(125)111-63(36-51-38-96-41-101-51)78(131)110-62(35-50-20-24-54(120)25-21-50)77(130)108-60(32-43(3)4)76(129)112-64(37-67(88)122)79(132)109-61(33-44(5)6)80(133)114-68(45(7)8)82(135)115-69(47(10)117)83(136)106-57(17-14-30-99-86(94)95)73(126)105-58(26-27-66(87)121)75(128)104-56(16-13-29-98-85(92)93)74(127)107-59(70(89)123)34-49-18-22-53(119)23-19-49/h18-25,38,41-47,52,55-65,68-69,100,116-117,119-120H,12-17,26-37,39-40H2,1-11H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,101)(H,102,118)(H,103,134)(H,104,128)(H,105,126)(H,106,136)(H,107,127)(H,108,130)(H,109,132)(H,110,131)(H,111,125)(H,112,129)(H,113,124)(H,114,133)(H,115,135)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t46-,47+,52-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,68-,69-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.76 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 1
(Homo sapiens (Human)) | BDBM50005530
(CHEMBL267633 | D-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-G...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r| Show InChI InChI=1S/C190H287N55O57/c1-16-94(9)149(180(296)235-129(81-141(194)255)169(285)227-124(74-93(7)8)172(288)240-150(95(10)17-2)181(297)241-151(100(15)248)182(298)222-116(32-23-67-209-190(203)204)156(272)221-118(57-60-140(193)254)161(277)219-114(30-21-65-207-188(199)200)157(273)224-121(152(196)268)76-102-39-49-108(250)50-40-102)239-173(289)127(79-105-45-55-111(253)56-46-105)230-168(284)128(80-106-86-205-90-211-106)231-159(275)115(31-22-66-208-189(201)202)220-165(281)123(73-92(5)6)225-155(271)97(12)213-174(290)134(88-246)237-167(283)126(78-104-43-53-110(252)54-44-104)229-166(282)125(77-103-41-51-109(251)52-42-103)228-158(274)113(29-20-64-206-187(197)198)217-153(269)96(11)212-163(279)122(72-91(3)4)226-170(286)131(84-147(264)265)233-162(278)119(59-62-145(260)261)218-154(270)98(13)214-177(293)137-34-25-68-242(137)183(299)99(14)215-164(280)130(83-146(262)263)232-160(276)117(58-61-144(258)259)216-143(257)87-210-176(292)136-33-24-70-244(136)186(302)133(82-142(195)256)236-171(287)132(85-148(266)267)234-178(294)139-36-27-71-245(139)185(301)120(28-18-19-63-191)223-175(291)135(89-247)238-179(295)138-35-26-69-243(138)184(300)112(192)75-101-37-47-107(249)48-38-101/h37-56,86,90-100,112-139,149-151,246-253H,16-36,57-85,87-89,191-192H2,1-15H3,(H2,193,254)(H2,194,255)(H2,195,256)(H2,196,268)(H,205,211)(H,210,292)(H,212,279)(H,213,290)(H,214,293)(H,215,280)(H,216,257)(H,217,269)(H,218,270)(H,219,277)(H,220,281)(H,221,272)(H,222,298)(H,223,291)(H,224,273)(H,225,271)(H,226,286)(H,227,285)(H,228,274)(H,229,282)(H,230,284)(H,231,275)(H,232,276)(H,233,278)(H,234,294)(H,235,296)(H,236,287)(H,237,283)(H,238,295)(H,239,289)(H,240,288)(H,241,297)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,266,267)(H4,197,198,206)(H4,199,200,207)(H4,201,202,208)(H4,203,204,209)/t94-,95-,96-,97-,98-,99-,100+,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,149-,150-,151-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.07 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091685
(CHEMBL411637 | N-alpha-Ac-[Trp28,30]PYY(22-36)-NH2...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C96H137N31O22/c1-47(2)35-68(119-91(147)74(45-128)125-80(136)49(5)113-51(7)130)85(141)115-64(20-13-33-108-95(102)103)83(139)123-72(40-56-44-106-46-112-56)88(144)120-69(37-53-24-28-58(132)29-25-53)86(142)121-70(38-54-42-110-61-17-10-8-15-59(54)61)87(143)124-73(41-76(98)134)89(145)122-71(39-55-43-111-62-18-11-9-16-60(55)62)90(146)126-77(48(3)4)92(148)127-78(50(6)129)93(149)117-65(21-14-34-109-96(104)105)81(137)116-66(30-31-75(97)133)84(140)114-63(19-12-32-107-94(100)101)82(138)118-67(79(99)135)36-52-22-26-57(131)27-23-52/h8-11,15-18,22-29,42-44,46-50,63-74,77-78,110-111,128-129,131-132H,12-14,19-21,30-41,45H2,1-7H3,(H2,97,133)(H2,98,134)(H2,99,135)(H,106,112)(H,113,130)(H,114,140)(H,115,141)(H,116,137)(H,117,149)(H,118,138)(H,119,147)(H,120,144)(H,121,142)(H,122,145)(H,123,139)(H,124,143)(H,125,136)(H,126,146)(H,127,148)(H4,100,101,107)(H4,102,103,108)(H4,104,105,109)/t49-,50+,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,77-,78-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.17 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091670
(CHEMBL428320 | N-alpha-Ac-[Trp27]PYY(22-36)-NH2(N-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C88H140N30O21/c1-42(2)31-60(112-83(137)66(40-119)116-72(126)46(9)104-48(11)121)77(131)106-56(20-15-29-100-87(94)95)75(129)114-64(36-51-39-98-41-103-51)80(134)113-63(35-50-38-102-54-18-13-12-17-53(50)54)79(133)110-61(32-43(3)4)78(132)115-65(37-68(90)124)81(135)111-62(33-44(5)6)82(136)117-69(45(7)8)84(138)118-70(47(10)120)85(139)108-57(21-16-30-101-88(96)97)73(127)107-58(26-27-67(89)123)76(130)105-55(19-14-28-99-86(92)93)74(128)109-59(71(91)125)34-49-22-24-52(122)25-23-49/h12-13,17-18,22-25,38-39,41-47,55-66,69-70,102,119-120,122H,14-16,19-21,26-37,40H2,1-11H3,(H2,89,123)(H2,90,124)(H2,91,125)(H,98,103)(H,104,121)(H,105,130)(H,106,131)(H,107,127)(H,108,139)(H,109,128)(H,110,133)(H,111,135)(H,112,137)(H,113,134)(H,114,129)(H,115,132)(H,116,126)(H,117,136)(H,118,138)(H4,92,93,99)(H4,94,95,100)(H4,96,97,101)/t46-,47+,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,69-,70-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Tested for the affinity for intestinal PYY from rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091658
(CHEMBL427594 | N-alpha-Ac-[Tyr22,Phe27]PYY(22-36)-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C92H143N29O22/c1-46(2)35-63(115-87(141)70(44-122)119-82(136)66(107-51(10)124)40-54-24-28-57(126)29-25-54)80(134)109-59(20-15-33-104-91(98)99)78(132)117-68(41-55-43-102-45-106-55)84(138)116-67(39-52-17-12-11-13-18-52)83(137)113-64(36-47(3)4)81(135)118-69(42-72(94)128)85(139)114-65(37-48(5)6)86(140)120-73(49(7)8)88(142)121-74(50(9)123)89(143)111-60(21-16-34-105-92(100)101)76(130)110-61(30-31-71(93)127)79(133)108-58(19-14-32-103-90(96)97)77(131)112-62(75(95)129)38-53-22-26-56(125)27-23-53/h11-13,17-18,22-29,43,45-50,58-70,73-74,122-123,125-126H,14-16,19-21,30-42,44H2,1-10H3,(H2,93,127)(H2,94,128)(H2,95,129)(H,102,106)(H,107,124)(H,108,133)(H,109,134)(H,110,130)(H,111,143)(H,112,131)(H,113,137)(H,114,139)(H,115,141)(H,116,138)(H,117,132)(H,118,135)(H,119,136)(H,120,140)(H,121,142)(H4,96,97,103)(H4,98,99,104)(H4,100,101,105)/t50-,58+,59+,60+,61+,62+,63+,64+,65+,66+,67+,68+,69+,70+,73+,74+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091687
(CHEMBL263350 | N-alpha-Ac-[Tic27]PYY(22-36)-NH2(N-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1Cc2ccccc2CC1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C87H139N29O21/c1-42(2)31-59(109-80(133)64(40-117)113-71(124)46(9)102-48(11)119)76(129)104-55(20-15-29-99-86(93)94)74(127)112-63(36-52-38-97-41-101-52)84(137)116-39-51-18-13-12-17-50(51)35-65(116)81(134)111-60(32-43(3)4)77(130)110-62(37-67(89)122)78(131)108-61(33-44(5)6)79(132)114-68(45(7)8)82(135)115-69(47(10)118)83(136)106-56(21-16-30-100-87(95)96)72(125)105-57(26-27-66(88)121)75(128)103-54(19-14-28-98-85(91)92)73(126)107-58(70(90)123)34-49-22-24-53(120)25-23-49/h12-13,17-18,22-25,38,41-47,54-65,68-69,117-118,120H,14-16,19-21,26-37,39-40H2,1-11H3,(H2,88,121)(H2,89,122)(H2,90,123)(H,97,101)(H,102,119)(H,103,128)(H,104,129)(H,105,125)(H,106,136)(H,107,126)(H,108,131)(H,109,133)(H,110,130)(H,111,134)(H,112,127)(H,113,124)(H,114,132)(H,115,135)(H4,91,92,98)(H4,93,94,99)(H4,95,96,100)/t46-,47+,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65?,68-,69-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091662
(CHEMBL410792 | N-alpha-Ac-[Nal30]PYY(22-36)-NH2(N-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C93H139N29O22/c1-46(2)36-65(115-88(142)71(44-123)120-77(131)49(7)108-51(9)125)82(136)110-61(21-14-34-105-92(99)100)80(134)118-69(41-56-43-103-45-107-56)85(139)116-67(39-53-25-29-58(127)30-26-53)84(138)114-66(37-47(3)4)83(137)119-70(42-73(95)129)86(140)117-68(40-55-18-12-17-54-16-10-11-19-59(54)55)87(141)121-74(48(5)6)89(143)122-75(50(8)124)90(144)112-62(22-15-35-106-93(101)102)78(132)111-63(31-32-72(94)128)81(135)109-60(20-13-33-104-91(97)98)79(133)113-64(76(96)130)38-52-23-27-57(126)28-24-52/h10-12,16-19,23-30,43,45-50,60-71,74-75,123-124,126-127H,13-15,20-22,31-42,44H2,1-9H3,(H2,94,128)(H2,95,129)(H2,96,130)(H,103,107)(H,108,125)(H,109,135)(H,110,136)(H,111,132)(H,112,144)(H,113,133)(H,114,138)(H,115,142)(H,116,139)(H,117,140)(H,118,134)(H,119,137)(H,120,131)(H,121,141)(H,122,143)(H4,97,98,104)(H4,99,100,105)(H4,101,102,106)/t49-,50+,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,74-,75-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.54 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091651
(CHEMBL411200 | N-alpha-Ac-[Nle24,28,Trp30,Nva31]PY...)Show SMILES CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C91H138N30O22/c1-7-10-19-59(112-87(142)70(45-122)120-75(130)47(4)107-49(6)124)76(131)109-62(23-15-36-103-90(97)98)80(135)118-68(41-53-44-101-46-106-53)85(140)116-66(39-51-27-31-55(126)32-28-51)83(138)111-60(20-11-8-2)79(134)119-69(42-72(93)128)86(141)117-67(40-52-43-105-57-21-13-12-18-56(52)57)84(139)108-58(17-9-3)82(137)121-73(48(5)123)88(143)114-63(24-16-37-104-91(99)100)77(132)113-64(33-34-71(92)127)81(136)110-61(22-14-35-102-89(95)96)78(133)115-65(74(94)129)38-50-25-29-54(125)30-26-50/h12-13,18,21,25-32,43-44,46-48,58-70,73,105,122-123,125-126H,7-11,14-17,19-20,22-24,33-42,45H2,1-6H3,(H2,92,127)(H2,93,128)(H2,94,129)(H,101,106)(H,107,124)(H,108,139)(H,109,131)(H,110,136)(H,111,138)(H,112,142)(H,113,132)(H,114,143)(H,115,133)(H,116,140)(H,117,141)(H,118,135)(H,119,134)(H,120,130)(H,121,137)(H4,95,96,102)(H4,97,98,103)(H4,99,100,104)/t47-,48+,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,73-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.73 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091671
(CHEMBL425095 | N-alpha-Ac-[Ala26,Phe27]PYY(22-36)-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C83H137N27O21/c1-40(2)33-56(106-78(129)61(39-111)108-67(118)44(9)96-47(12)113)73(124)99-51(21-16-30-93-81(87)88)69(120)97-45(10)68(119)103-59(37-48-19-14-13-15-20-48)75(126)104-57(34-41(3)4)74(125)107-60(38-63(85)116)76(127)105-58(35-42(5)6)77(128)109-64(43(7)8)79(130)110-65(46(11)112)80(131)101-53(23-18-32-95-83(91)92)70(121)100-54(28-29-62(84)115)72(123)98-52(22-17-31-94-82(89)90)71(122)102-55(66(86)117)36-49-24-26-50(114)27-25-49/h13-15,19-20,24-27,40-46,51-61,64-65,111-112,114H,16-18,21-23,28-39H2,1-12H3,(H2,84,115)(H2,85,116)(H2,86,117)(H,96,113)(H,97,120)(H,98,123)(H,99,124)(H,100,121)(H,101,131)(H,102,122)(H,103,119)(H,104,126)(H,105,127)(H,106,129)(H,107,125)(H,108,118)(H,109,128)(H,110,130)(H4,87,88,93)(H4,89,90,94)(H4,91,92,95)/t44-,45-,46+,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.84 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091681
(CHEMBL406128 | N-alpha-Ac-[CH2-NH25-26]PYY(22-36)-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)CN[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C86H141N29O21/c1-42(2)31-60(110-81(134)65(40-116)113-71(124)46(9)102-48(11)118)76(129)103-51(15-12-28-97-84(90)91)39-100-59(36-52-38-96-41-101-52)75(128)111-63(35-50-20-24-54(120)25-21-50)78(131)108-61(32-43(3)4)77(130)112-64(37-67(88)122)79(132)109-62(33-44(5)6)80(133)114-68(45(7)8)82(135)115-69(47(10)117)83(136)106-56(17-14-30-99-86(94)95)72(125)105-57(26-27-66(87)121)74(127)104-55(16-13-29-98-85(92)93)73(126)107-58(70(89)123)34-49-18-22-53(119)23-19-49/h18-25,38,41-47,51,55-65,68-69,100,116-117,119-120H,12-17,26-37,39-40H2,1-11H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,101)(H,102,118)(H,103,129)(H,104,127)(H,105,125)(H,106,136)(H,107,126)(H,108,131)(H,109,132)(H,110,134)(H,111,128)(H,112,130)(H,113,124)(H,114,133)(H,115,135)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t46-,47+,51-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,68-,69-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.22 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091678
(Ala-Ser-Leu-Arg-His-Phe-Leu-Asn-Leu-Val-Thr-Arg-Gl...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccsc1)C(N)=O Show InChI InChI=1S/C84H137N29O20S/c1-41(2)30-56(107-79(131)62(38-114)111-68(120)45(9)99-47(11)116)73(125)101-52(21-16-27-96-83(90)91)71(123)109-60(35-50-37-94-40-98-50)76(128)108-59(33-48-18-13-12-14-19-48)75(127)105-57(31-42(3)4)74(126)110-61(36-64(86)118)77(129)106-58(32-43(5)6)78(130)112-65(44(7)8)80(132)113-66(46(10)115)81(133)103-53(22-17-28-97-84(92)93)69(121)102-54(23-24-63(85)117)72(124)100-51(20-15-26-95-82(88)89)70(122)104-55(67(87)119)34-49-25-29-134-39-49/h12-14,18-19,25,29,37,39-46,51-62,65-66,114-115H,15-17,20-24,26-28,30-36,38H2,1-11H3,(H2,85,117)(H2,86,118)(H2,87,119)(H,94,98)(H,99,116)(H,100,124)(H,101,125)(H,102,121)(H,103,133)(H,104,122)(H,105,127)(H,106,129)(H,107,131)(H,108,128)(H,109,123)(H,110,126)(H,111,120)(H,112,130)(H,113,132)(H4,88,89,95)(H4,90,91,96)(H4,92,93,97)/t45-,46+,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,65-,66-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091680
(CHEMBL411800 | N-alpha-Ac-[CH2-NH32-33]PYY(22-36)-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](CN[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O Show InChI InChI=1S/C86H141N29O21/c1-42(2)31-59(109-82(135)66(40-116)114-71(124)46(9)102-48(11)118)76(129)104-56(17-14-30-99-86(94)95)74(127)111-63(36-51-38-96-41-101-51)79(132)110-62(35-50-20-24-53(120)25-21-50)78(131)107-60(32-43(3)4)77(130)112-64(37-68(88)122)80(133)108-61(33-44(5)6)81(134)115-69(45(7)8)83(136)113-65(47(10)117)39-100-54(15-12-28-97-84(90)91)72(125)105-57(26-27-67(87)121)75(128)103-55(16-13-29-98-85(92)93)73(126)106-58(70(89)123)34-49-18-22-52(119)23-19-49/h18-25,38,41-47,54-66,69,100,116-117,119-120H,12-17,26-37,39-40H2,1-11H3,(H2,87,121)(H2,88,122)(H2,89,123)(H,96,101)(H,102,118)(H,103,128)(H,104,129)(H,105,125)(H,106,126)(H,107,131)(H,108,133)(H,109,135)(H,110,132)(H,111,127)(H,112,130)(H,113,136)(H,114,124)(H,115,134)(H4,90,91,97)(H4,92,93,98)(H4,94,95,99)/t46-,47+,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65+,66-,69-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.03 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(RAT) | BDBM50091671
(CHEMBL425095 | N-alpha-Ac-[Ala26,Phe27]PYY(22-36)-...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C83H137N27O21/c1-40(2)33-56(106-78(129)61(39-111)108-67(118)44(9)96-47(12)113)73(124)99-51(21-16-30-93-81(87)88)69(120)97-45(10)68(119)103-59(37-48-19-14-13-15-20-48)75(126)104-57(34-41(3)4)74(125)107-60(38-63(85)116)76(127)105-58(35-42(5)6)77(128)109-64(43(7)8)79(130)110-65(46(11)112)80(131)101-53(23-18-32-95-83(91)92)70(121)100-54(28-29-62(84)115)72(123)98-52(22-17-31-94-82(89)90)71(122)102-55(66(86)117)36-49-24-26-50(114)27-25-49/h13-15,19-20,24-27,40-46,51-61,64-65,111-112,114H,16-18,21-23,28-39H2,1-12H3,(H2,84,115)(H2,85,116)(H2,86,117)(H,96,113)(H,97,120)(H,98,123)(H,99,124)(H,100,121)(H,101,131)(H,102,122)(H,103,119)(H,104,126)(H,105,127)(H,106,129)(H,107,125)(H,108,118)(H,109,128)(H,110,130)(H4,87,88,93)(H4,89,90,94)(H4,91,92,95)/t44-,45-,46+,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,64-,65-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Neuropeptide Y receptor type 2
(Homo sapiens (Human)) | BDBM50091677
(CHEMBL405527 | N-alpha-Ac-[Phe22,27]PYY(22-36)-NH2...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O Show InChI InChI=1S/C92H143N29O21/c1-47(2)36-63(115-87(140)70(45-122)119-82(135)66(107-52(10)124)40-53-20-13-11-14-21-53)80(133)109-59(25-18-34-104-91(98)99)78(131)117-68(42-56-44-102-46-106-56)84(137)116-67(41-54-22-15-12-16-23-54)83(136)113-64(37-48(3)4)81(134)118-69(43-72(94)127)85(138)114-65(38-49(5)6)86(139)120-73(50(7)8)88(141)121-74(51(9)123)89(142)111-60(26-19-35-105-92(100)101)76(129)110-61(31-32-71(93)126)79(132)108-58(24-17-33-103-90(96)97)77(130)112-62(75(95)128)39-55-27-29-57(125)30-28-55/h11-16,20-23,27-30,44,46-51,58-70,73-74,122-123,125H,17-19,24-26,31-43,45H2,1-10H3,(H2,93,126)(H2,94,127)(H2,95,128)(H,102,106)(H,107,124)(H,108,132)(H,109,133)(H,110,129)(H,111,142)(H,112,130)(H,113,136)(H,114,138)(H,115,140)(H,116,137)(H,117,131)(H,118,134)(H,119,135)(H,120,139)(H,121,141)(H4,96,97,103)(H4,98,99,104)(H4,100,101,105)/t51-,58+,59+,60+,61+,62+,63+,64+,65+,66+,67+,68+,69+,70+,73+,74+/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.61 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Cincinnati Medical Center
Curated by ChEMBL
| Assay Description
Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line |
J Med Chem 43: 3420-7 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WCX |
More data for this
Ligand-Target Pair | |
Search and Browse
