Found 1187 hits with Last Name = 'evans' and Initial = 'k' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Carboxypeptidase B
(Sus scrofa) | BDBM50201438
((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6](-[#6]-[#16])-[#6](-[#8])=O Show InChI InChI=1S/C7H15N3O2S/c8-7(9)10-3-1-2-5(4-13)6(11)12/h5,13H,1-4H2,(H,11,12)(H4,8,9,10) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 0.420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of porcine pancreatic carboxypeptidase B |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Carboxypeptidase N catalytic chain
(Homo sapiens (Human)) | BDBM50201438
((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6](-[#6]-[#16])-[#6](-[#8])=O Show InChI InChI=1S/C7H15N3O2S/c8-7(9)10-3-1-2-5(4-13)6(11)12/h5,13H,1-4H2,(H,11,12)(H4,8,9,10) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human plasma carboxypeptidase N |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(RAT) | BDBM50384444
(CHEMBL2035510)Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2cccc(F)c2c1 Show InChI InChI=1S/C21H17FN2O4/c1-11(2)21(19(26)24-20(27)28-21)15-8-9-17(23-18(15)25)13-7-6-12-4-3-5-16(22)14(12)10-13/h3-11H,1-2H3,(H,23,25)(H,24,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs... |
ACS Med Chem Lett 1: 316-320 (2010)
Article DOI: 10.1021/ml100077x
BindingDB Entry DOI: 10.7270/Q2BG2Q1F |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50384444
(CHEMBL2035510)Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2cccc(F)c2c1 Show InChI InChI=1S/C21H17FN2O4/c1-11(2)21(19(26)24-20(27)28-21)15-8-9-17(23-18(15)25)13-7-6-12-4-3-5-16(22)14(12)10-13/h3-11H,1-2H3,(H,23,25)(H,24,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ... |
ACS Med Chem Lett 1: 316-320 (2010)
Article DOI: 10.1021/ml100077x
BindingDB Entry DOI: 10.7270/Q2BG2Q1F |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50201438
((+/-)-5-guanidino-2-(mercaptomethyl)pentanoic acid...)Show SMILES [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6](-[#6]-[#16])-[#6](-[#8])=O Show InChI InChI=1S/C7H15N3O2S/c8-7(9)10-3-1-2-5(4-13)6(11)12/h5,13H,1-4H2,(H,11,12)(H4,8,9,10) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50384443
(CHEMBL1770317)Show SMILES CC(C)C1(OC(O)=NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |c:6| Show InChI InChI=1S/C21H18N2O4/c1-12(2)21(19(25)23-20(26)27-21)16-9-10-17(22-18(16)24)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H,22,24)(H,23,25,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.01 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Binding affinity to human EP3 |
ACS Med Chem Lett 1: 316-320 (2010)
Article DOI: 10.1021/ml100077x
BindingDB Entry DOI: 10.7270/Q2BG2Q1F |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50384445
(CHEMBL2035508)Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2n(C)ccc2c1 Show InChI InChI=1S/C20H19N3O4/c1-11(2)20(18(25)22-19(26)27-20)14-5-6-15(21-17(14)24)12-4-7-16-13(10-12)8-9-23(16)3/h4-11H,1-3H3,(H,21,24)(H,22,25,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ... |
ACS Med Chem Lett 1: 316-320 (2010)
Article DOI: 10.1021/ml100077x
BindingDB Entry DOI: 10.7270/Q2BG2Q1F |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417191
(CHEMBL1272136)Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3c(F)cccc3Cl)c2=O)c1 Show InChI InChI=1S/C21H19ClFN3O2/c1-2-14-6-3-7-15(12-14)24-21(28)25-19-10-5-11-26(20(19)27)13-16-17(22)8-4-9-18(16)23/h3-12H,2,13H2,1H3,(H2,24,25,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(RAT) | BDBM50384445
(CHEMBL2035508)Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2n(C)ccc2c1 Show InChI InChI=1S/C20H19N3O4/c1-11(2)20(18(25)22-19(26)27-20)14-5-6-15(21-17(14)24)12-4-7-16-13(10-12)8-9-23(16)3/h4-11H,1-3H3,(H,21,24)(H,22,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs... |
ACS Med Chem Lett 1: 316-320 (2010)
Article DOI: 10.1021/ml100077x
BindingDB Entry DOI: 10.7270/Q2BG2Q1F |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226610
((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)Show InChI InChI=1S/C12H21N3O2/c1-2-6-15-8-11(14-9-15)7-10(12(16)17)4-3-5-13/h8-10H,2-7,13H2,1H3,(H,16,17)/t10-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(RAT) | BDBM50384443
(CHEMBL1770317)Show SMILES CC(C)C1(OC(O)=NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |c:6| Show InChI InChI=1S/C21H18N2O4/c1-12(2)21(19(25)23-20(26)27-21)16-9-10-17(22-18(16)24)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H,22,24)(H,23,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs... |
ACS Med Chem Lett 1: 316-320 (2010)
Article DOI: 10.1021/ml100077x
BindingDB Entry DOI: 10.7270/Q2BG2Q1F |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50384443
(CHEMBL1770317)Show SMILES CC(C)C1(OC(O)=NC1=O)c1ccc([nH]c1=O)-c1ccc2ccccc2c1 |c:6| Show InChI InChI=1S/C21H18N2O4/c1-12(2)21(19(25)23-20(26)27-21)16-9-10-17(22-18(16)24)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,1-2H3,(H,22,24)(H,23,25,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ... |
ACS Med Chem Lett 1: 316-320 (2010)
Article DOI: 10.1021/ml100077x
BindingDB Entry DOI: 10.7270/Q2BG2Q1F |
More data for this
Ligand-Target Pair | |
Carboxypeptidase A1
(Bos taurus (bovine)) | BDBM50109593
(2-Benzyl-3-mercapto-propionic acid | 2-Mercaptomet...)Show InChI InChI=1S/C10H12O2S/c11-10(12)9(7-13)6-8-4-2-1-3-5-8/h1-5,9,13H,6-7H2,(H,11,12) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of bovine pancreatic carboxypeptidase A |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(RAT) | BDBM50384446
(CHEMBL2035509)Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc(C)c(C)c1 Show InChI InChI=1S/C19H20N2O4/c1-10(2)19(17(23)21-18(24)25-19)14-7-8-15(20-16(14)22)13-6-5-11(3)12(4)9-13/h5-10H,1-4H3,(H,20,22)(H,21,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs... |
ACS Med Chem Lett 1: 316-320 (2010)
Article DOI: 10.1021/ml100077x
BindingDB Entry DOI: 10.7270/Q2BG2Q1F |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50384446
(CHEMBL2035509)Show SMILES CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc(C)c(C)c1 Show InChI InChI=1S/C19H20N2O4/c1-10(2)19(17(23)21-18(24)25-19)14-7-8-15(20-16(14)22)13-6-5-11(3)12(4)9-13/h5-10H,1-4H3,(H,20,22)(H,21,23,24) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 19.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ... |
ACS Med Chem Lett 1: 316-320 (2010)
Article DOI: 10.1021/ml100077x
BindingDB Entry DOI: 10.7270/Q2BG2Q1F |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50329821
(1-(1-(2-chloro-6-fluorobenzyl)-2-oxo-1,2-dihydropy...)Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3c(F)cccc3Cl)c2=O)c1 Show InChI InChI=1S/C20H17ClFN3O3/c1-28-14-6-2-5-13(11-14)23-20(27)24-18-9-4-10-25(19(18)26)12-15-16(21)7-3-8-17(15)22/h2-11H,12H2,1H3,(H2,23,24,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 25.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226605
((+/-)-5-amino-2-((1-propyl-1H-imidazol-4-yl)methyl...)Show InChI InChI=1S/C12H21N3O2/c1-2-6-15-8-11(14-9-15)7-10(12(16)17)4-3-5-13/h8-10H,2-7,13H2,1H3,(H,16,17) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417192
(CHEMBL1271476)Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 50.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417206
(CHEMBL1271527)Show SMILES CC(C)c1cccc(NC(=O)Nc2cccn(Cc3ccccc3Cl)c2=O)c1 Show InChI InChI=1S/C22H22ClN3O2/c1-15(2)16-8-5-9-18(13-16)24-22(28)25-20-11-6-12-26(21(20)27)14-17-7-3-4-10-19(17)23/h3-13,15H,14H2,1-2H3,(H2,24,25,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 63.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226598
((S)-2-(2-aminoethylamino)-3-(1-butyl-1H-imidazol-4...)Show InChI InChI=1S/C12H22N4O2/c1-2-3-6-16-8-10(15-9-16)7-11(12(17)18)14-5-4-13/h8-9,11,14H,2-7,13H2,1H3,(H,17,18)/t11-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226606
((S)-2-(2-aminoethylamino)-3-(1-propyl-1H-imidazol-...)Show InChI InChI=1S/C11H20N4O2/c1-2-5-15-7-9(14-8-15)6-10(11(16)17)13-4-3-12/h7-8,10,13H,2-6,12H2,1H3,(H,16,17)/t10-/m0/s1 | PDB
MMDB
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| 84 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226597
((S)-2-(2-aminoethylamino)-3-(1-isobutyl-1H-imidazo...)Show InChI InChI=1S/C12H22N4O2/c1-9(2)6-16-7-10(15-8-16)5-11(12(17)18)14-4-3-13/h7-9,11,14H,3-6,13H2,1-2H3,(H,17,18)/t11-/m0/s1 | PDB
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| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417190
(CHEMBL1272086)Show InChI InChI=1S/C21H20FN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27) | PDB
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| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226611
((S)-2-(2-aminoethylamino)-3-(1-(3-hydroxypropyl)-1...)Show InChI InChI=1S/C11H20N4O3/c12-2-3-13-10(11(17)18)6-9-7-15(8-14-9)4-1-5-16/h7-8,10,13,16H,1-6,12H2,(H,17,18)/t10-/m0/s1 | PDB
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| 111 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226614
((S)-2-(2-aminoethylamino)-3-(1-(cyclobutylmethyl)-...)Show InChI InChI=1S/C13H22N4O2/c14-4-5-15-12(13(18)19)6-11-8-17(9-16-11)7-10-2-1-3-10/h8-10,12,15H,1-7,14H2,(H,18,19)/t12-/m0/s1 | PDB
MMDB
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| 124 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417189
(CHEMBL1272085)Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3ccc(F)cc3Cl)c2=O)c1 Show InChI InChI=1S/C21H19ClFN3O2/c1-2-14-5-3-6-17(11-14)24-21(28)25-19-7-4-10-26(20(19)27)13-15-8-9-16(23)12-18(15)22/h3-12H,2,13H2,1H3,(H2,24,25,28) | PDB
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| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417188
(CHEMBL1272030)Show SMILES CCc1cccc(NC(=O)Nc2ccc(C)n(Cc3ccccc3Cl)c2=O)c1 Show InChI InChI=1S/C22H22ClN3O2/c1-3-16-7-6-9-18(13-16)24-22(28)25-20-12-11-15(2)26(21(20)27)14-17-8-4-5-10-19(17)23/h4-13H,3,14H2,1-2H3,(H2,24,25,28) | PDB
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| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417195
(CHEMBL1272083)Show InChI InChI=1S/C19H15Cl2N3O2/c20-14-7-2-1-6-13(14)12-24-11-5-10-17(18(24)25)23-19(26)22-16-9-4-3-8-15(16)21/h1-11H,12H2,(H2,22,23,26) | PDB
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| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226613
((S)-2-(2-aminoethylamino)-3-(1-phenethyl-1H-imidaz...)Show InChI InChI=1S/C16H22N4O2/c17-7-8-18-15(16(21)22)10-14-11-20(12-19-14)9-6-13-4-2-1-3-5-13/h1-5,11-12,15,18H,6-10,17H2,(H,21,22)/t15-/m0/s1 | PDB
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| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226607
((+/-)-2-((1H-imidazol-4-yl)methyl)-5-aminopentanoi...)Show InChI InChI=1S/C9H15N3O2/c10-3-1-2-7(9(13)14)4-8-5-11-6-12-8/h5-7H,1-4,10H2,(H,11,12)(H,13,14) | PDB
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| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417209
(CHEMBL1271634)Show InChI InChI=1S/C20H18ClN3O3/c1-27-16-8-4-7-15(12-16)22-20(26)23-18-10-5-11-24(19(18)25)13-14-6-2-3-9-17(14)21/h2-12H,13H2,1H3,(H2,22,23,26) | PDB
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| 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417194
(CHEMBL1272029)Show InChI InChI=1S/C19H15ClFN3O2/c20-14-7-2-1-6-13(14)12-24-11-5-10-17(18(24)25)23-19(26)22-16-9-4-3-8-15(16)21/h1-11H,12H2,(H2,22,23,26) | PDB
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| 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(RAT) | BDBM50417192
(CHEMBL1271476)Show InChI InChI=1S/C21H20ClN3O2/c1-2-15-7-5-9-17(13-15)23-21(27)24-19-11-6-12-25(20(19)26)14-16-8-3-4-10-18(16)22/h3-13H,2,14H2,1H3,(H2,23,24,27) | PDB
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| 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Inhibition of rat EP3 receptor |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226602
((S)-2-(2-aminoethylamino)-3-(1-pentyl-1H-imidazol-...)Show InChI InChI=1S/C13H24N4O2/c1-2-3-4-7-17-9-11(16-10-17)8-12(13(18)19)15-6-5-14/h9-10,12,15H,2-8,14H2,1H3,(H,18,19)/t12-/m0/s1 | PDB
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| 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50384442
(CHEMBL2035507)Show SMILES Oc1[nH]c(=O)oc1-c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C18H12N2O4/c21-16-13(15-17(22)20-18(23)24-15)7-8-14(19-16)12-6-5-10-3-1-2-4-11(10)9-12/h1-9,22H,(H,19,21)(H,20,23) | PDB
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| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3c receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced calcium mobilization after 24 hrs by ... |
ACS Med Chem Lett 1: 316-320 (2010)
Article DOI: 10.1021/ml100077x
BindingDB Entry DOI: 10.7270/Q2BG2Q1F |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417186
(CHEMBL1271918)Show SMILES CCc1cccc(NC(=O)Nc2cc(C)cn(Cc3ccccc3Cl)c2=O)c1 Show InChI InChI=1S/C22H22ClN3O2/c1-3-16-7-6-9-18(12-16)24-22(28)25-20-11-15(2)13-26(21(20)27)14-17-8-4-5-10-19(17)23/h4-13H,3,14H2,1-2H3,(H2,24,25,28) | PDB
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| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417228
(CHEMBL1272031)Show SMILES CCc1cccc(NC(=O)Nc2cccn(Cc3cccc(c3)C(F)(F)F)c2=O)c1 Show InChI InChI=1S/C22H20F3N3O2/c1-2-15-6-4-9-18(13-15)26-21(30)27-19-10-5-11-28(20(19)29)14-16-7-3-8-17(12-16)22(23,24)25/h3-13H,2,14H2,1H3,(H2,26,27,30) | PDB
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| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B
(Sus scrofa) | BDBM50226610
((2S)-5-AMINO-2-[(1-PROPYL-1H-IMIDAZOL-4-YL)METHYL]...)Show InChI InChI=1S/C12H21N3O2/c1-2-6-15-8-11(14-9-15)7-10(12(16)17)4-3-5-13/h8-10H,2-7,13H2,1H3,(H,16,17)/t10-/m0/s1 | PDB
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PDB
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| 206 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of porcine pancreatic carboxypeptidase B |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226601
((2S)-2-[(2-aminoethyl)amino]-3-(1-methyl-1H-imidaz...)Show InChI InChI=1S/C9H16N4O2/c1-13-5-7(12-6-13)4-8(9(14)15)11-3-2-10/h5-6,8,11H,2-4,10H2,1H3,(H,14,15)/t8-/m0/s1 | PDB
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| 235 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226599
((S)-2-(2-aminoethylamino)-3-(1-ethyl-1H-imidazol-4...)Show InChI InChI=1S/C10H18N4O2/c1-2-14-6-8(13-7-14)5-9(10(15)16)12-4-3-11/h6-7,9,12H,2-5,11H2,1H3,(H,15,16)/t9-/m0/s1 | PDB
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| 250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417205
(CHEMBL1271475)Show InChI InChI=1S/C20H18ClN3O2/c1-14-6-4-8-16(12-14)22-20(26)23-18-10-5-11-24(19(18)25)13-15-7-2-3-9-17(15)21/h2-12H,13H2,1H3,(H2,22,23,26) | PDB
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| 251 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226608
((S)-2-(2-aminoethylamino)-3-(1-benzyl-1H-imidazol-...)Show InChI InChI=1S/C15H20N4O2/c16-6-7-17-14(15(20)21)8-13-10-19(11-18-13)9-12-4-2-1-3-5-12/h1-5,10-11,14,17H,6-9,16H2,(H,20,21)/t14-/m0/s1 | PDB
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| Article
PubMed
| 269 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226603
((+/-)-5-amino-2-(mercaptomethyl)pentanoic acid | C...)Show InChI InChI=1S/C6H13NO2S/c7-3-1-2-5(4-10)6(8)9/h5,10H,1-4,7H2,(H,8,9) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(RAT) | BDBM50384442
(CHEMBL2035507)Show SMILES Oc1[nH]c(=O)oc1-c1ccc([nH]c1=O)-c1ccc2ccccc2c1 Show InChI InChI=1S/C18H12N2O4/c21-16-13(15-17(22)20-18(23)24-15)7-8-14(19-16)12-6-5-10-3-1-2-4-11(10)9-12/h1-9,22H,(H,19,21)(H,20,23) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Antagonist activity at rat EP3 receptor expressed in human U2OS cells co-expressing Gqi5 assessed as inhibition of PGE2-induced response after 24 hrs... |
ACS Med Chem Lett 1: 316-320 (2010)
Article DOI: 10.1021/ml100077x
BindingDB Entry DOI: 10.7270/Q2BG2Q1F |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417211
(CHEMBL1271687)Show InChI InChI=1S/C20H18BrN3O3/c1-27-16-8-4-7-15(12-16)22-20(26)23-18-10-5-11-24(19(18)25)13-14-6-2-3-9-17(14)21/h2-12H,13H2,1H3,(H2,22,23,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226600
((2S)-2-[(2-aminoethyl)amino]-3-(1H-imidazol-4-yl)p...)Show InChI InChI=1S/C8H14N4O2/c9-1-2-11-7(8(13)14)3-6-4-10-5-12-6/h4-5,7,11H,1-3,9H2,(H,10,12)(H,13,14)/t7-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 344 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417203
(CHEMBL1272295)Show InChI InChI=1S/C19H15ClIN3O2/c20-16-8-2-1-5-13(16)12-24-10-4-9-17(18(24)25)23-19(26)22-15-7-3-6-14(21)11-15/h1-11H,12H2,(H2,22,23,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417213
(CHEMBL1271802)Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3cccc(Cl)c3)c2=O)c1 Show InChI InChI=1S/C20H18ClN3O3/c1-27-17-8-3-7-16(12-17)22-20(26)23-18-9-4-10-24(19(18)25)13-14-5-2-6-15(21)11-14/h2-12H,13H2,1H3,(H2,22,23,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50417217
(CHEMBL1271972)Show SMILES COc1cccc(NC(=O)Nc2cccn(Cc3ccc(F)cc3Cl)c2=O)c1 Show InChI InChI=1S/C20H17ClFN3O3/c1-28-16-5-2-4-15(11-16)23-20(27)24-18-6-3-9-25(19(18)26)12-13-7-8-14(22)10-17(13)21/h2-11H,12H2,1H3,(H2,23,24,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor expressed in human U2OS cells assessed as inhibition of PGE2-induced intracellular calcium mobilization by ... |
Bioorg Med Chem Lett 20: 6744-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.08.137
BindingDB Entry DOI: 10.7270/Q25M65Z8 |
More data for this
Ligand-Target Pair | |
Carboxypeptidase B2
(Homo sapiens (Human)) | BDBM50226609
((S)-2-(2-aminoethylamino)-3-(1-isopropyl-1H-imidaz...)Show InChI InChI=1S/C11H20N4O2/c1-8(2)15-6-9(14-7-15)5-10(11(16)17)13-4-3-12/h6-8,10,13H,3-5,12H2,1-2H3,(H,16,17)/t10-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human TAFIa |
J Med Chem 50: 6095-103 (2007)
Article DOI: 10.1021/jm0702433
BindingDB Entry DOI: 10.7270/Q2T153CG |
More data for this
Ligand-Target Pair | |
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