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Compile Data Set for Download or QSAR

Found 3 hits with Last Name = 'finger' and Initial = 'ld'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Flap endonuclease 1 [1-336]


(Homo sapiens (Human))
BDBM197162
PNG
(3-hydroxy-1-(4-methoxybenzyl)quinazoline-2,4(1H,3H...)
Show SMILES COc1ccc(Cn2c3ccccc3c(=O)n(O)c2=O)cc1
Show InChI InChI=1S/C16H14N2O4/c1-22-12-8-6-11(7-9-12)10-17-14-5-3-2-4-13(14)15(19)18(21)16(17)20/h2-9,21H,10H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16.9n/an/an/an/a7.5n/a



University of Sheffield



Assay Description
Reaction mixtures containing twelve different concentrations of FAM-labeled DF1 (Supplementary Fig. 5a) substrate were prepared in reaction buffer (R...


Nat Chem Biol 12: 815-21 (2016)


Article DOI: 10.1038/nchembio.2148
BindingDB Entry DOI: 10.7270/Q2RJ4H88
More data for this
Ligand-Target Pair
Flap endonuclease 1 [1-336]


(Homo sapiens (Human))
BDBM197161
PNG
(1-(cyclopropylmethyl)-3-hydroxyquinazoline-2,4(1H,...)
Show SMILES On1c(=O)n(CC2CC2)c2ccccc2c1=O
Show InChI InChI=1S/C12H12N2O3/c15-11-9-3-1-2-4-10(9)13(7-8-5-6-8)12(16)14(11)17/h1-4,8,17H,5-7H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

MCE
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 30n/an/an/an/a7.5n/a



University of Sheffield



Assay Description
Reaction mixtures containing twelve different concentrations of FAM-labeled DF1 (Supplementary Fig. 5a) substrate were prepared in reaction buffer (R...


Nat Chem Biol 12: 815-21 (2016)


Article DOI: 10.1038/nchembio.2148
BindingDB Entry DOI: 10.7270/Q2RJ4H88
More data for this
Ligand-Target Pair
Flap endonuclease 1 [1-336]


(Homo sapiens (Human))
BDBM50157840
PNG
(1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-3-...)
Show SMILES On1c(=O)n(CC2COc3ccccc3O2)c2ccsc2c1=O
Show InChI InChI=1S/C15H12N2O5S/c18-14-13-10(5-6-23-13)16(15(19)17(14)20)7-9-8-21-11-3-1-2-4-12(11)22-9/h1-6,9,20H,7-8H2
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Patents

PDB
Article
PubMed
n/an/a 46.4n/an/an/an/a7.5n/a



University of Sheffield



Assay Description
Reaction mixtures containing twelve different concentrations of FAM-labeled DF1 (Supplementary Fig. 5a) substrate were prepared in reaction buffer (R...


Nat Chem Biol 12: 815-21 (2016)


Article DOI: 10.1038/nchembio.2148
BindingDB Entry DOI: 10.7270/Q2RJ4H88
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)