Compile Data Set for Download or QSAR

Found 122 hits with Last Name = 'fujisawa' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50116105 (3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...) Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(-1.91,-13.39,;-3.24,-14.16,;-4.58,-13.4,;-5.91,-14.18,;-7.24,-13.41,;-8.57,-14.19,;-9.91,-13.42,;-5.9,-15.72,;-7.22,-16.49,;-7.23,-18.03,;-8.56,-18.8,;-5.9,-18.8,;-4.55,-18.03,;-3.07,-18.5,;-2.16,-17.24,;-.62,-17.23,;-3.09,-15.99,;-4.56,-16.48,;-2.58,-19.96,;-3.61,-21.11,;-3.13,-22.57,;-1.62,-22.88,;-.59,-21.72,;-1.08,-20.27,;-.06,-19.11,;-1.13,-24.34,;.38,-24.65,;-2.15,-25.5,)| Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	8.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF-stimulated cAMP accumulation				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420920 (CHEMBL2087549 | CHEMBL2087567) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(OC)cc(COC)cc1OC |(-4.48,2.67,;-3.74,1.32,;-2.2,1.29,;-1.32,.02,;.16,.47,;1.48,-.33,;2.82,.42,;2.86,1.96,;1.54,2.75,;.19,2.01,;-1.27,2.51,;-1.71,3.99,;-.66,5.11,;.86,4.84,;2.3,5.36,;2.03,3.85,;-3.21,4.34,;-3.58,5.83,;-5.06,6.26,;-5.43,7.76,;-4.32,8.82,;-2.84,8.39,;-2.47,6.9,;1.44,-1.87,;2.76,-2.66,;4.11,-1.92,;5.43,-2.72,;2.73,-4.2,;1.38,-4.95,;1.35,-6.49,;2.67,-7.28,;2.64,-8.82,;.07,-4.15,;.1,-2.61,;-1.22,-1.81,;-2.57,-2.56,)| Show InChI InChI=1S/C29H39N3O4/c1-5-23-29(31(17-20-9-10-20)18-21-11-13-36-14-12-21)25-8-6-7-24(32(25)30-23)28-26(34-3)15-22(19-33-2)16-27(28)35-4/h6-8,15-16,20-21H,5,9-14,17-19H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in IMR32 cells assessed as inhibition of CRF-stimulated cAMP accumulation				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 2 (Homo sapiens (Human))	BDBM50420920 (CHEMBL2087549 | CHEMBL2087567) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(OC)cc(COC)cc1OC |(-4.48,2.67,;-3.74,1.32,;-2.2,1.29,;-1.32,.02,;.16,.47,;1.48,-.33,;2.82,.42,;2.86,1.96,;1.54,2.75,;.19,2.01,;-1.27,2.51,;-1.71,3.99,;-.66,5.11,;.86,4.84,;2.3,5.36,;2.03,3.85,;-3.21,4.34,;-3.58,5.83,;-5.06,6.26,;-5.43,7.76,;-4.32,8.82,;-2.84,8.39,;-2.47,6.9,;1.44,-1.87,;2.76,-2.66,;4.11,-1.92,;5.43,-2.72,;2.73,-4.2,;1.38,-4.95,;1.35,-6.49,;2.67,-7.28,;2.64,-8.82,;.07,-4.15,;.1,-2.61,;-1.22,-1.81,;-2.57,-2.56,)| Show InChI InChI=1S/C29H39N3O4/c1-5-23-29(31(17-20-9-10-20)18-21-11-13-36-14-12-21)25-8-6-7-24(32(25)30-23)28-26(34-3)15-22(19-33-2)16-27(28)35-4/h6-8,15-16,20-21H,5,9-14,17-19H2,1-4H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human CRF2 receptor expressed in IMR32 cells assessed as inhibition of CRF-stimulated cAMP accumulation				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50116105 (3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...) Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(-1.91,-13.39,;-3.24,-14.16,;-4.58,-13.4,;-5.91,-14.18,;-7.24,-13.41,;-8.57,-14.19,;-9.91,-13.42,;-5.9,-15.72,;-7.22,-16.49,;-7.23,-18.03,;-8.56,-18.8,;-5.9,-18.8,;-4.55,-18.03,;-3.07,-18.5,;-2.16,-17.24,;-.62,-17.23,;-3.09,-15.99,;-4.56,-16.48,;-2.58,-19.96,;-3.61,-21.11,;-3.13,-22.57,;-1.62,-22.88,;-.59,-21.72,;-1.08,-20.27,;-.06,-19.11,;-1.13,-24.34,;.38,-24.65,;-2.15,-25.5,)| Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at CRF1 receptor in human IMR32 cells assessed as inhibition of CRF-induced intracellular cAMP accumulation after 30 mins by immu...				J Med Chem 55: 8450-63 (2012) Article DOI: 10.1021/jm300864p BindingDB Entry DOI: 10.7270/Q2KD202P
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50398565 (CHEMBL2179195) Show SMILES CCCCN(C1CCOCC1)c1c(OC)nn2c(csc12)-c1c(OC)cc(COCC)cc1OC |(2.51,-41.6,;3.29,-42.93,;4.83,-42.92,;5.59,-41.58,;7.13,-41.58,;7.85,-40.22,;9.39,-40.17,;10.11,-38.82,;9.3,-37.51,;7.76,-37.56,;7.03,-38.92,;7.67,-43.03,;6.79,-44.29,;5.26,-44.32,;4.52,-45.67,;7.72,-45.51,;9.18,-45.01,;10.66,-45.45,;11.53,-44.19,;10.6,-42.96,;9.15,-43.47,;11.4,-46.8,;10.62,-48.12,;9.08,-48.09,;8.28,-49.41,;11.36,-49.46,;12.9,-49.49,;13.65,-50.84,;15.19,-50.87,;15.93,-52.21,;17.47,-52.24,;13.69,-48.17,;12.94,-46.82,;13.74,-45.5,;12.99,-44.16,)| Show InChI InChI=1S/C26H37N3O5S/c1-6-8-11-28(19-9-12-34-13-10-19)24-25(32-5)27-29-20(17-35-26(24)29)23-21(30-3)14-18(16-33-7-2)15-22(23)31-4/h14-15,17,19H,6-13,16H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.10	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at CRF1 receptor in human IMR32 cells assessed as inhibition of CRF-induced intracellular cAMP accumulation after 30 mins by immu...				J Med Chem 55: 8450-63 (2012) Article DOI: 10.1021/jm300864p BindingDB Entry DOI: 10.7270/Q2KD202P
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420904 (CHEMBL2087550) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CC1)-c1ccc(OC)cc1Cl Show InChI InChI=1S/C24H28ClN3O/c1-3-21-24(27(14-16-7-8-16)15-17-9-10-17)23-6-4-5-22(28(23)26-21)19-12-11-18(29-2)13-20(19)25/h4-6,11-13,16-17H,3,7-10,14-15H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420906 (CHEMBL2087552) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CC1)-c1ccc(C)cc1OC Show InChI InChI=1S/C25H31N3O/c1-4-21-25(27(15-18-9-10-18)16-19-11-12-19)23-7-5-6-22(28(23)26-21)20-13-8-17(2)14-24(20)29-3/h5-8,13-14,18-19H,4,9-12,15-16H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420908 (CHEMBL2087554) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CC1)-c1c(C)cc(OC)cc1C |(-4.21,2.14,;-3.44,.81,;-1.9,.81,;-.99,-.43,;.47,.05,;1.81,-.72,;3.14,.05,;3.13,1.59,;1.8,2.36,;.47,1.59,;-1,2.06,;-1.48,3.53,;-2.98,3.84,;-3.38,5.33,;-2.99,6.82,;-4.48,6.42,;-.45,4.67,;-.85,6.16,;-.45,7.65,;-1.94,7.25,;1.81,-2.26,;3.14,-3.03,;4.48,-2.25,;3.15,-4.57,;1.81,-5.34,;1.82,-6.88,;3.15,-7.65,;.48,-4.57,;.48,-3.03,;-.86,-2.26,)| Show InChI InChI=1S/C26H33N3O/c1-5-22-26(28(15-19-9-10-19)16-20-11-12-20)24-8-6-7-23(29(24)27-22)25-17(2)13-21(30-4)14-18(25)3/h6-8,13-14,19-20H,5,9-12,15-16H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420909 (CHEMBL2087555) Show SMILES CCCN(CCC)c1c(CC)nn2c(cccc12)-c1ccc(OC)cc1Cl Show InChI InChI=1S/C22H28ClN3O/c1-5-13-25(14-6-2)22-19(7-3)24-26-20(9-8-10-21(22)26)17-12-11-16(27-4)15-18(17)23/h8-12,15H,5-7,13-14H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420905 (CHEMBL2087551) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CC1)-c1ccc(OC)cc1C Show InChI InChI=1S/C25H31N3O/c1-4-22-25(27(15-18-8-9-18)16-19-10-11-19)24-7-5-6-23(28(24)26-22)21-13-12-20(29-3)14-17(21)2/h5-7,12-14,18-19H,4,8-11,15-16H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420916 (CHEMBL2087562) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(OC)cc(C)cc1OC |(-4.48,1.41,;-3.7,.09,;-2.16,.1,;-1.25,-1.14,;.21,-.65,;1.55,-1.41,;2.88,-.63,;2.87,.91,;1.53,1.67,;.2,.89,;-1.27,1.35,;-1.75,2.81,;-.73,3.96,;.79,3.73,;2.22,4.3,;2,2.77,;-3.26,3.12,;-3.67,4.6,;-5.16,4.99,;-5.57,6.48,;-4.49,7.57,;-3,7.19,;-2.59,5.7,;1.57,-2.95,;2.91,-3.71,;4.23,-2.93,;5.57,-3.69,;2.92,-5.25,;1.59,-6.03,;1.6,-7.57,;.25,-5.27,;.24,-3.73,;-1.1,-2.97,;-2.43,-3.75,)| Show InChI InChI=1S/C28H37N3O3/c1-5-22-28(30(17-20-9-10-20)18-21-11-13-34-14-12-21)24-8-6-7-23(31(24)29-22)27-25(32-3)15-19(2)16-26(27)33-4/h6-8,15-16,20-21H,5,9-14,17-18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated cAMP accumulation after 30 mins by fluo...				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420912 (CHEMBL2087558) Show SMILES CCc1nn2c(cccc2c1N(CCCF)CC1CC1)-c1c(C)cc(C)cc1OC |(-4.75,1.19,;-3.97,-.14,;-2.43,-.13,;-1.52,-1.37,;-.06,-.88,;1.28,-1.65,;2.61,-.87,;2.6,.67,;1.26,1.43,;-.07,.66,;-1.54,1.12,;-2.02,2.58,;-1,3.74,;-1.56,5.17,;-.59,6.37,;-1.16,7.81,;-3.53,2.9,;-4.09,4.33,;-5.29,5.29,;-3.86,5.85,;1.29,-3.19,;-.04,-3.96,;-1.38,-3.2,;-.03,-5.5,;1.3,-6.27,;1.31,-7.81,;2.63,-5.49,;2.62,-3.95,;3.95,-3.17,;5.29,-3.93,)| Show InChI InChI=1S/C25H32FN3O/c1-5-20-25(28(13-7-12-26)16-19-10-11-19)22-9-6-8-21(29(22)27-20)24-18(3)14-17(2)15-23(24)30-4/h6,8-9,14-15,19H,5,7,10-13,16H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50394516 (CHEMBL2160157) Show SMILES CCN(CC)c1ccc(OC)c2nc(c(C)cc12)-c1c(Cl)cc(COC)cc1OC |(3.38,8.07,;2.04,7.32,;2.01,5.78,;3.33,4.99,;4.69,5.72,;.67,5.04,;-.65,5.83,;-2,5.08,;-2.02,3.54,;-3.37,2.79,;-4.69,3.58,;-.7,2.75,;-.73,1.21,;.6,.42,;1.94,1.17,;3.26,.37,;1.96,2.7,;.64,3.5,;.57,-1.12,;1.89,-1.91,;3.24,-1.17,;1.87,-3.45,;.52,-4.2,;.5,-5.74,;1.82,-6.53,;1.8,-8.07,;-.8,-3.41,;-.77,-1.87,;-2.1,-1.08,;-3.44,-1.83,)| Show InChI InChI=1S/C24H29ClN2O3/c1-7-27(8-2)19-9-10-20(29-5)24-17(19)11-15(3)23(26-24)22-18(25)12-16(14-28-4)13-21(22)30-6/h9-13H,7-8,14H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated...				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420915 (CHEMBL2087561) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(C)cc(C)cc1OC |(-4.15,-1.62,;-3.38,-.29,;-2.03,-.24,;-1.12,-1.48,;.34,-1,;1.68,-1.76,;3.01,-.99,;3,.55,;1.66,1.32,;.33,.54,;-1.13,1.01,;-1.62,2.47,;-3.13,2.78,;-4.21,1.69,;-5.69,1.28,;-4.6,.2,;-.59,3.62,;-1.15,5.05,;-.19,6.26,;-.75,7.69,;-2.27,7.92,;-3.23,6.72,;-2.67,5.29,;1.69,-3.3,;.36,-4.08,;-.98,-3.32,;.37,-5.62,;1.71,-6.38,;1.71,-7.92,;3.03,-5.61,;3.03,-4.07,;4.36,-3.29,;5.69,-4.05,)| Show InChI InChI=1S/C28H37N3O2/c1-5-23-28(30(17-21-9-10-21)18-22-11-13-33-14-12-22)25-8-6-7-24(31(25)29-23)27-20(3)15-19(2)16-26(27)32-4/h6-8,15-16,21-22H,5,9-14,17-18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420916 (CHEMBL2087562) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(OC)cc(C)cc1OC |(-4.48,1.41,;-3.7,.09,;-2.16,.1,;-1.25,-1.14,;.21,-.65,;1.55,-1.41,;2.88,-.63,;2.87,.91,;1.53,1.67,;.2,.89,;-1.27,1.35,;-1.75,2.81,;-.73,3.96,;.79,3.73,;2.22,4.3,;2,2.77,;-3.26,3.12,;-3.67,4.6,;-5.16,4.99,;-5.57,6.48,;-4.49,7.57,;-3,7.19,;-2.59,5.7,;1.57,-2.95,;2.91,-3.71,;4.23,-2.93,;5.57,-3.69,;2.92,-5.25,;1.59,-6.03,;1.6,-7.57,;.25,-5.27,;.24,-3.73,;-1.1,-2.97,;-2.43,-3.75,)| Show InChI InChI=1S/C28H37N3O3/c1-5-22-28(30(17-20-9-10-20)18-21-11-13-34-14-12-21)24-8-6-7-23(31(24)29-22)27-25(32-3)15-19(2)16-26(27)33-4/h6-8,15-16,20-21H,5,9-14,17-18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50389532 (CHEMBL2063375) Show SMILES CCN(CCOC)c1ccc(C)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC |(47.84,-10.28,;49.18,-11.04,;49.18,-12.58,;50.52,-13.35,;50.52,-14.89,;51.86,-15.65,;51.87,-17.19,;47.85,-13.36,;46.52,-12.59,;45.19,-13.36,;45.18,-14.91,;43.85,-15.68,;46.52,-15.67,;46.51,-17.21,;47.85,-17.99,;49.19,-17.21,;50.52,-17.98,;49.19,-15.67,;47.86,-14.91,;47.85,-19.52,;46.51,-20.29,;45.18,-19.52,;43.85,-20.29,;46.51,-21.83,;47.85,-22.6,;47.85,-24.14,;46.52,-24.91,;45.18,-24.14,;49.19,-21.82,;49.18,-20.29,;50.51,-19.51,;51.85,-20.28,)| Show InChI InChI=1S/C26H34N2O4/c1-8-28(11-12-29-4)21-10-9-17(2)25-20(21)13-18(3)26(27-25)24-22(31-6)14-19(16-30-5)15-23(24)32-7/h9-10,13-15H,8,11-12,16H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated...				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420920 (CHEMBL2087549 | CHEMBL2087567) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(OC)cc(COC)cc1OC |(-4.48,2.67,;-3.74,1.32,;-2.2,1.29,;-1.32,.02,;.16,.47,;1.48,-.33,;2.82,.42,;2.86,1.96,;1.54,2.75,;.19,2.01,;-1.27,2.51,;-1.71,3.99,;-.66,5.11,;.86,4.84,;2.3,5.36,;2.03,3.85,;-3.21,4.34,;-3.58,5.83,;-5.06,6.26,;-5.43,7.76,;-4.32,8.82,;-2.84,8.39,;-2.47,6.9,;1.44,-1.87,;2.76,-2.66,;4.11,-1.92,;5.43,-2.72,;2.73,-4.2,;1.38,-4.95,;1.35,-6.49,;2.67,-7.28,;2.64,-8.82,;.07,-4.15,;.1,-2.61,;-1.22,-1.81,;-2.57,-2.56,)| Show InChI InChI=1S/C29H39N3O4/c1-5-23-29(31(17-20-9-10-20)18-21-11-13-36-14-12-21)25-8-6-7-24(32(25)30-23)28-26(34-3)15-22(19-33-2)16-27(28)35-4/h6-8,15-16,20-21H,5,9-14,17-19H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated cAMP accumulation after 30 mins by fluo...				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420907 (CHEMBL2087553) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CC1)-c1c(C)cc(C)cc1OC |(-4.21,1.75,;-3.44,.42,;-1.9,.42,;-.99,-.82,;.48,-.34,;1.81,-1.1,;3.14,-.32,;3.14,1.22,;1.8,1.98,;.47,1.2,;-1,1.67,;-1.48,3.14,;-2.99,3.45,;-3.39,4.94,;-3,6.43,;-4.49,6.02,;-.45,4.29,;-.86,5.77,;-.47,7.26,;-1.95,6.86,;1.82,-2.64,;3.16,-3.4,;4.49,-2.63,;3.16,-4.94,;1.83,-5.72,;1.84,-7.26,;.5,-4.96,;.49,-3.42,;-.85,-2.65,;-2.18,-3.43,)| Show InChI InChI=1S/C26H33N3O/c1-5-21-26(28(15-19-9-10-19)16-20-11-12-20)23-8-6-7-22(29(23)27-21)25-18(3)13-17(2)14-24(25)30-4/h6-8,13-14,19-20H,5,9-12,15-16H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420930 (CHEMBL2087795) Show SMILES COc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(OC)cc(C)cc1OC |(-4.48,1.44,;-3.71,.1,;-2.17,.1,;-1.27,-1.14,;.2,-.67,;1.53,-1.44,;2.87,-.67,;2.87,.87,;1.53,1.64,;.2,.87,;-1.27,1.35,;-1.74,2.81,;-.71,3.96,;.81,3.72,;2.25,4.27,;2.01,2.75,;-3.25,3.13,;-3.65,4.62,;-5.13,5.02,;-5.53,6.51,;-4.44,7.6,;-2.96,7.2,;-2.56,5.71,;1.53,-2.98,;2.86,-3.75,;4.2,-2.98,;5.53,-3.75,;2.86,-5.29,;1.53,-6.06,;1.53,-7.6,;.2,-5.29,;.2,-3.75,;-1.14,-2.98,;-2.47,-3.75,)| Show InChI InChI=1S/C27H35N3O4/c1-18-14-23(31-2)25(24(15-18)32-3)21-6-5-7-22-26(27(33-4)28-30(21)22)29(16-19-8-9-19)17-20-10-12-34-13-11-20/h5-7,14-15,19-20H,8-13,16-17H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420935 (CHEMBL2087799) Show SMILES COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3COCCO3)c(SC)nn12 |(2.79,-8.78,;2.8,-7.24,;1.47,-6.46,;1.48,-4.92,;2.82,-4.16,;2.83,-2.62,;4.17,-1.86,;5.5,-2.64,;1.5,-1.84,;.16,-2.6,;-1.17,-1.82,;-2.5,-2.58,;.15,-4.14,;1.51,-.3,;2.85,.46,;2.86,2,;1.53,2.78,;.19,2.02,;-1.27,2.51,;-1.73,3.98,;-.69,5.11,;.83,4.86,;2.27,5.4,;2.02,3.88,;-3.24,4.31,;-3.62,5.8,;-2.53,6.88,;-2.92,8.37,;-4.4,8.78,;-5.5,7.7,;-5.11,6.21,;-2.18,1.27,;-3.72,1.28,;-4.48,2.62,;-1.28,.02,;.18,.48,)| Show InChI InChI=1S/C27H35N3O5S/c1-31-16-19-12-23(32-2)25(24(13-19)33-3)21-6-5-7-22-26(27(36-4)28-30(21)22)29(14-18-8-9-18)15-20-17-34-10-11-35-20/h5-7,12-13,18,20H,8-11,14-17H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50394527 (CHEMBL2160161) Show SMILES CCN(CC)c1ccc(Cl)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC |(4.04,5.73,;2.69,4.99,;1.36,5.77,;1.38,7.31,;2.72,8.07,;.02,5.01,;-1.3,5.79,;-2.64,5.03,;-2.66,3.49,;-4,2.74,;-1.33,2.71,;-1.34,1.17,;-.02,.39,;1.32,1.15,;2.65,.37,;1.34,2.69,;.01,3.47,;-.03,-1.15,;-1.37,-1.91,;-2.7,-1.13,;-4.04,-1.88,;-1.39,-3.45,;-.06,-4.23,;-.07,-5.77,;-1.41,-6.53,;-1.43,-8.07,;1.28,-3.47,;1.3,-1.93,;2.64,-1.17,;3.96,-1.95,)| Show InChI InChI=1S/C24H29ClN2O3/c1-7-27(8-2)19-10-9-18(25)24-17(19)11-15(3)23(26-24)22-20(29-5)12-16(14-28-4)13-21(22)30-6/h9-13H,7-8,14H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated...				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420927 (CHEMBL2087574) Show SMILES COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(SC)nn12 |(2.74,-8.79,;2.75,-7.25,;1.43,-6.47,;1.45,-4.93,;2.79,-4.17,;2.81,-2.63,;4.15,-1.88,;5.47,-2.66,;1.48,-1.85,;.14,-2.6,;-1.18,-1.82,;-2.53,-2.57,;.12,-4.14,;1.5,-.31,;2.84,.45,;2.86,1.99,;1.53,2.77,;.19,2.02,;-1.27,2.51,;-1.73,3.98,;-.68,5.11,;.84,4.85,;2.28,5.39,;2.02,3.87,;-3.23,4.32,;-3.61,5.81,;-5.09,6.22,;-5.47,7.72,;-4.37,8.79,;-2.89,8.38,;-2.51,6.89,;-2.19,1.27,;-3.73,1.29,;-4.48,2.63,;-1.29,.02,;.18,.48,)| Show InChI InChI=1S/C28H37N3O4S/c1-32-18-21-14-24(33-2)26(25(15-21)34-3)22-6-5-7-23-27(28(36-4)29-31(22)23)30(16-19-8-9-19)17-20-10-12-35-13-11-20/h5-7,14-15,19-20H,8-13,16-18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated cAMP accumulation after 30 mins by fluo...				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50394520 (CHEMBL2160170) Show SMILES CCN(CC)c1ccc(OC)c2nc(c(CC)cc12)-c1c(OC)cc(COC)cc1OC |(4.67,5.76,;3.33,5,;2,5.77,;2.01,7.31,;3.35,8.08,;.67,5.01,;-.66,5.78,;-2,5.02,;-2.01,3.48,;-3.34,2.71,;-4.67,3.49,;-.68,2.7,;-.68,1.16,;.65,.39,;1.98,1.15,;3.32,.38,;4.65,1.15,;1.99,2.69,;.66,3.47,;.64,-1.15,;-.69,-1.92,;-2.03,-1.14,;-3.36,-1.91,;-.7,-3.46,;.63,-4.23,;.62,-5.77,;-.71,-6.54,;-.72,-8.08,;1.97,-3.47,;1.97,-1.93,;3.31,-1.16,;4.64,-1.94,)| Show InChI InChI=1S/C26H34N2O4/c1-8-18-15-19-20(28(9-2)10-3)11-12-21(30-5)26(19)27-25(18)24-22(31-6)13-17(16-29-4)14-23(24)32-7/h11-15H,8-10,16H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated...				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420914 (CHEMBL2087560) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CCCO1)-c1c(C)cc(C)cc1OC |(-4.19,-1.4,;-3.42,-.06,;-1.88,-.05,;-.97,-1.29,;.49,-.81,;1.83,-1.57,;3.16,-.8,;3.15,.74,;1.81,1.51,;.48,.73,;-.98,1.2,;-1.47,2.66,;-2.98,2.97,;-4.3,2.19,;-5.07,.86,;-5.84,2.18,;-.44,3.81,;-1,5.24,;-2.49,5.64,;-2.58,7.17,;-1.15,7.73,;-.17,6.54,;1.84,-3.11,;.51,-3.89,;-.83,-3.13,;.52,-5.43,;1.86,-6.19,;1.86,-7.73,;3.19,-5.42,;3.18,-3.88,;4.51,-3.1,;5.84,-3.86,)| Show InChI InChI=1S/C27H35N3O2/c1-5-22-27(29(16-20-11-12-20)17-21-8-7-13-32-21)24-10-6-9-23(30(24)28-22)26-19(3)14-18(2)15-25(26)31-4/h6,9-10,14-15,20-21H,5,7-8,11-13,16-17H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420937 (CHEMBL2087801) Show SMILES COCCN(CC1CCOCC1)c1c(SC)nn2c(cccc12)-c1c(OC)cc(COC)cc1OC |(-3.55,8.8,;-3.16,7.31,;-4.26,6.23,;-3.88,4.74,;-2.37,4.4,;-1.02,5.88,;.5,5.63,;1.04,4.18,;2.56,3.93,;3.54,5.12,;3,6.56,;1.48,6.81,;-1.77,2.49,;-2.69,1.26,;-4.23,1.27,;-4.99,2.61,;-1.79,0,;-.32,.47,;1,-.32,;2.34,.44,;2.36,1.98,;1.03,2.76,;-.31,2.01,;.99,-1.86,;2.32,-2.64,;3.66,-1.88,;4.99,-2.66,;2.3,-4.18,;.96,-4.94,;.95,-6.48,;2.28,-7.26,;2.27,-8.8,;-.36,-4.15,;-.35,-2.61,;-1.68,-1.83,;-3.02,-2.59,)| Show InChI InChI=1S/C27H37N3O5S/c1-31-14-11-29(17-19-9-12-35-13-10-19)26-22-8-6-7-21(30(22)28-27(26)36-5)25-23(33-3)15-20(18-32-2)16-24(25)34-4/h6-8,15-16,19H,9-14,17-18H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420927 (CHEMBL2087574) Show SMILES COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(SC)nn12 |(2.74,-8.79,;2.75,-7.25,;1.43,-6.47,;1.45,-4.93,;2.79,-4.17,;2.81,-2.63,;4.15,-1.88,;5.47,-2.66,;1.48,-1.85,;.14,-2.6,;-1.18,-1.82,;-2.53,-2.57,;.12,-4.14,;1.5,-.31,;2.84,.45,;2.86,1.99,;1.53,2.77,;.19,2.02,;-1.27,2.51,;-1.73,3.98,;-.68,5.11,;.84,4.85,;2.28,5.39,;2.02,3.87,;-3.23,4.32,;-3.61,5.81,;-5.09,6.22,;-5.47,7.72,;-4.37,8.79,;-2.89,8.38,;-2.51,6.89,;-2.19,1.27,;-3.73,1.29,;-4.48,2.63,;-1.29,.02,;.18,.48,)| Show InChI InChI=1S/C28H37N3O4S/c1-32-18-21-14-24(33-2)26(25(15-21)34-3)22-6-5-7-23-27(28(36-4)29-31(22)23)30(16-19-8-9-19)17-20-10-12-35-13-11-20/h5-7,14-15,19-20H,8-13,16-18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50394525 (CHEMBL2160164) Show SMILES CCN(CC)c1ccc(C#N)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC |(4.59,5.83,;3.28,5.03,;1.94,5.78,;1.92,7.32,;3.25,8.11,;.61,5,;-.73,5.75,;-2.05,4.97,;-2.04,3.43,;-3.36,2.65,;-4.69,1.86,;-.7,2.67,;-.68,1.13,;.66,.38,;1.99,1.16,;3.33,.41,;1.97,2.7,;.63,3.46,;.68,-1.16,;-.65,-1.95,;-1.99,-1.19,;-3.31,-1.97,;-.63,-3.49,;.71,-4.24,;.73,-5.78,;-.6,-6.57,;-.58,-8.11,;2.04,-3.46,;2.02,-1.92,;3.35,-1.13,;4.69,-1.89,)| Show InChI InChI=1S/C25H29N3O3/c1-7-28(8-2)20-10-9-18(14-26)25-19(20)11-16(3)24(27-25)23-21(30-5)12-17(15-29-4)13-22(23)31-6/h9-13H,7-8,15H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated...				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420913 (CHEMBL2087559) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOC1)-c1c(C)cc(C)cc1OC |(-4.51,-1.39,;-3.74,-.05,;-2.2,-.05,;-1.3,-1.28,;.17,-.81,;1.5,-1.58,;2.83,-.81,;2.83,.73,;1.5,1.5,;.17,.73,;-1.3,1.21,;-1.78,2.67,;-3.5,2.95,;-4.3,4.26,;-5.81,4.72,;-4.41,5.79,;-.69,3.76,;-1.09,5.25,;-2.52,5.8,;-2.44,7.34,;-.96,7.74,;-.12,6.44,;1.51,-3.12,;.17,-3.89,;-1.16,-3.12,;.17,-5.43,;1.51,-6.2,;1.51,-7.74,;2.84,-5.42,;2.85,-3.89,;4.18,-3.12,;5.51,-3.89,)| Show InChI InChI=1S/C27H35N3O2/c1-5-22-27(29(15-20-9-10-20)16-21-11-12-32-17-21)24-8-6-7-23(30(24)28-22)26-19(3)13-18(2)14-25(26)31-4/h6-8,13-14,20-21H,5,9-12,15-17H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420931 (CHEMBL2087796) Show SMILES COc1cc(C)cc(OC)c1-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(SC)nn12 |(5.46,-3.84,;4.14,-3.05,;2.8,-3.8,;2.78,-5.34,;1.43,-6.1,;1.41,-7.64,;.11,-5.31,;.13,-3.77,;-1.19,-2.98,;-2.54,-3.73,;1.47,-3.02,;1.49,-1.48,;2.84,-.72,;2.86,.82,;1.54,1.6,;.19,.85,;-1.27,1.35,;-1.72,2.82,;-.68,3.95,;.84,3.69,;2.29,4.22,;2.02,2.7,;-3.23,3.16,;-3.6,4.65,;-5.09,5.07,;-5.46,6.56,;-4.36,7.64,;-2.88,7.22,;-2.5,5.72,;-2.19,.11,;-3.73,.13,;-4.48,1.48,;-1.3,-1.15,;.17,-.69,)| Show InChI InChI=1S/C27H35N3O3S/c1-18-14-23(31-2)25(24(15-18)32-3)21-6-5-7-22-26(27(34-4)28-30(21)22)29(16-19-8-9-19)17-20-10-12-33-13-11-20/h5-7,14-15,19-20H,8-13,16-17H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated cAMP accumulation after 30 mins by fluo...				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420924 (CHEMBL2087571) Show SMILES CCCN(CC1CCOCC1)c1c(CC)nn2c(cccc12)-c1c(OC)cc(C)cc1OC |(-3.23,6.87,;-4.32,5.78,;-3.92,4.3,;-2.41,3.98,;-1.07,5.46,;.45,5.22,;1,3.79,;2.52,3.54,;3.49,4.74,;2.94,6.18,;1.42,6.42,;-1.79,2.07,;-2.7,.83,;-4.24,.83,;-5.01,2.16,;-1.79,-.42,;-.33,.06,;1.01,-.71,;2.34,.06,;2.34,1.6,;1.01,2.37,;-.33,1.6,;1.01,-2.25,;2.34,-3.02,;3.67,-2.25,;5.01,-3.02,;2.34,-4.56,;1.01,-5.33,;1.01,-6.87,;-.33,-4.56,;-.33,-3.02,;-1.66,-2.25,;-2.99,-3.02,)| Show InChI InChI=1S/C27H37N3O3/c1-6-13-29(18-20-11-14-33-15-12-20)27-21(7-2)28-30-22(9-8-10-23(27)30)26-24(31-4)16-19(3)17-25(26)32-5/h8-10,16-17,20H,6-7,11-15,18H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420917 (CHEMBL2087563) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(C)cc(OC)cc1OC |(-3.66,-1.15,;-2.89,.19,;-1.35,.17,;-.46,-1.08,;1.01,-.62,;2.34,-1.4,;3.68,-.64,;3.69,.9,;2.37,1.68,;1.03,.92,;-.44,1.41,;-.9,2.88,;-2.4,3.21,;-3.5,2.13,;-4.99,1.75,;-3.91,.65,;.14,4.01,;-.4,5.46,;.58,6.65,;.05,8.09,;-1.47,8.34,;-2.45,7.15,;-1.91,5.71,;2.32,-2.94,;3.65,-3.72,;4.99,-2.97,;3.64,-5.26,;2.3,-6.02,;2.28,-7.56,;3.61,-8.34,;.97,-5.24,;.98,-3.7,;-.34,-2.92,;-1.68,-3.67,)| Show InChI InChI=1S/C28H37N3O3/c1-5-23-28(30(17-20-9-10-20)18-21-11-13-34-14-12-21)25-8-6-7-24(31(25)29-23)27-19(2)15-22(32-3)16-26(27)33-4/h6-8,15-16,20-21H,5,9-14,17-18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420911 (CHEMBL2087557) Show SMILES CCc1nn2c(cccc2c1N(CCOC)CC1CC1)-c1c(C)cc(C)cc1OC |(-4.74,1.26,;-3.99,-.08,;-2.45,-.09,;-1.55,-1.35,;-.08,-.88,;1.25,-1.66,;2.59,-.9,;2.6,.64,;1.27,1.42,;-.07,.66,;-1.53,1.15,;-1.99,2.61,;-.96,3.75,;-1.5,5.19,;-.52,6.38,;-1.06,7.82,;-3.5,2.95,;-4.04,4.39,;-5.23,5.37,;-3.79,5.91,;1.23,-3.2,;-.11,-3.96,;-1.43,-3.18,;-.12,-5.5,;1.21,-6.28,;1.2,-7.82,;2.55,-5.52,;2.56,-3.98,;3.9,-3.22,;5.23,-4,)| Show InChI InChI=1S/C25H33N3O2/c1-6-20-25(27(12-13-29-4)16-19-10-11-19)22-9-7-8-21(28(22)26-20)24-18(3)14-17(2)15-23(24)30-5/h7-9,14-15,19H,6,10-13,16H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420938 (CHEMBL2087564) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(OC)cc(OC)cc1OC |(-4.48,1.81,;-3.71,.48,;-2.17,.49,;-1.26,-.76,;.2,-.28,;1.54,-1.05,;2.87,-.27,;2.87,1.27,;1.53,2.03,;.2,1.26,;-1.27,1.73,;-1.74,3.2,;-.72,4.34,;.8,4.11,;2.24,4.66,;2,3.14,;-3.25,3.51,;-3.65,5,;-5.14,5.4,;-5.54,6.88,;-4.46,7.97,;-2.97,7.58,;-2.57,6.09,;1.54,-2.59,;2.88,-3.35,;4.21,-2.58,;5.54,-3.35,;2.88,-4.89,;1.55,-5.67,;1.55,-7.21,;2.89,-7.97,;.21,-4.9,;.21,-3.36,;-1.13,-2.59,;-2.46,-3.37,)| Show InChI InChI=1S/C28H37N3O4/c1-5-22-28(30(17-19-9-10-19)18-20-11-13-35-14-12-20)24-8-6-7-23(31(24)29-22)27-25(33-3)15-21(32-2)16-26(27)34-4/h6-8,15-16,19-20H,5,9-14,17-18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50394514 (CHEMBL2160159) Show SMILES CCN(CC)c1ccc(OC)c2nc(c(C)cc12)-c1c(OC)cc(C)cc1OC |(3.3,6.94,;1.97,6.16,;1.98,4.62,;3.32,3.86,;4.55,4.53,;.65,3.84,;-.69,4.61,;-2.02,3.83,;-2.01,2.29,;-3.34,1.52,;-4.68,2.28,;-.67,1.53,;-.67,-.01,;.67,-.78,;2,,;3.34,-.76,;1.99,1.54,;.66,2.3,;.67,-2.32,;-.66,-3.09,;-1.99,-2.33,;-3.32,-3.1,;-.65,-4.63,;.69,-5.4,;.69,-6.94,;2.02,-4.62,;2.01,-3.08,;3.34,-2.3,;4.68,-3.07,)| Show InChI InChI=1S/C24H30N2O3/c1-8-26(9-2)18-10-11-19(27-5)24-17(18)14-16(4)23(25-24)22-20(28-6)12-15(3)13-21(22)29-7/h10-14H,8-9H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated...				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50398579 (CHEMBL2179182) Show SMILES COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCCO4)c(OC)nn23)c(OC)c1 |(15.79,-14.95,;15.04,-13.6,;13.5,-13.58,;12.76,-12.23,;11.22,-12.2,;10.47,-10.86,;8.93,-10.83,;8.13,-12.15,;11.26,-9.54,;10.52,-8.19,;11.39,-6.93,;10.46,-5.7,;9.01,-6.22,;7.53,-5.77,;6.99,-4.32,;5.47,-4.08,;4.5,-5.27,;3.05,-5.81,;4.25,-6.79,;7.74,-2.98,;6.8,-1.76,;7.22,-.29,;5.94,.59,;4.73,-.37,;5.25,-1.82,;6.65,-7.03,;5.11,-7.06,;4.37,-8.41,;7.58,-8.26,;9.04,-7.75,;12.8,-9.56,;13.59,-8.25,;15.13,-8.27,;13.55,-10.92,)| Show InChI InChI=1S/C25H33N3O5S/c1-29-14-17-10-20(30-2)22(21(11-17)31-3)19-15-34-25-23(24(32-4)26-28(19)25)27(12-16-7-8-16)13-18-6-5-9-33-18/h10-11,15-16,18H,5-9,12-14H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay				J Med Chem 55: 8450-63 (2012) Article DOI: 10.1021/jm300864p BindingDB Entry DOI: 10.7270/Q2KD202P
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50389539 (CHEMBL2063382) Show SMILES CCN(CC)c1ccc(C)c2nc(c(Cl)cc12)-c1c(OC)cc(COC)cc1OC |(62.06,-27.68,;63.4,-28.45,;63.41,-29.99,;64.74,-30.75,;64.75,-32.29,;62.08,-30.76,;60.74,-30,;59.41,-30.77,;59.41,-32.31,;58.08,-33.08,;60.74,-33.08,;60.74,-34.62,;62.07,-35.39,;63.41,-34.62,;64.75,-35.38,;63.41,-33.08,;62.08,-32.31,;62.08,-36.93,;60.74,-37.7,;59.41,-36.93,;58.07,-37.7,;60.74,-39.24,;62.07,-40.01,;62.08,-41.55,;60.74,-42.32,;59.41,-41.55,;63.41,-39.23,;63.41,-37.69,;64.74,-36.92,;66.07,-37.69,)| Show InChI InChI=1S/C24H29ClN2O3/c1-7-27(8-2)19-10-9-15(3)23-17(19)13-18(25)24(26-23)22-20(29-5)11-16(14-28-4)12-21(22)30-6/h9-13H,7-8,14H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-induced intracellular cAMP production preincubated...				Bioorg Med Chem 20: 6559-78 (2012) Article DOI: 10.1016/j.bmc.2012.09.028 BindingDB Entry DOI: 10.7270/Q2B56KVZ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50398566 (CHEMBL2179196) Show SMILES CCCCN(C1CCOCC1)c1c(OC)nn2c(csc12)-c1c(OC)cc(cc1OC)C#N |(24.95,-40.75,;25.72,-42.08,;27.26,-42.07,;28.03,-40.74,;29.57,-40.73,;30.29,-39.37,;31.83,-39.32,;32.55,-37.97,;31.74,-36.66,;30.19,-36.71,;29.46,-38.07,;30.11,-42.18,;29.23,-43.44,;27.69,-43.47,;26.95,-44.82,;30.16,-44.66,;31.62,-44.16,;33.1,-44.6,;33.97,-43.34,;33.04,-42.11,;31.59,-42.62,;33.84,-45.95,;33.05,-47.27,;31.51,-47.24,;30.72,-48.57,;33.8,-48.62,;35.34,-48.64,;36.13,-47.33,;35.38,-45.97,;36.17,-44.66,;37.71,-44.68,;36.09,-49.99,;36.84,-51.33,)| Show InChI InChI=1S/C24H30N4O4S/c1-5-6-9-27(17-7-10-32-11-8-17)22-23(31-4)26-28-18(15-33-24(22)28)21-19(29-2)12-16(14-25)13-20(21)30-3/h12-13,15,17H,5-11H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay				J Med Chem 55: 8450-63 (2012) Article DOI: 10.1021/jm300864p BindingDB Entry DOI: 10.7270/Q2KD202P
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50398587 (CHEMBL2179197 | US8530504, 4) Show SMILES COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCOCC4)c(C)nn23)c(OC)c1 |(17.24,-37.02,;16.5,-35.68,;14.96,-35.65,;14.21,-34.3,;12.67,-34.28,;11.93,-32.93,;10.39,-32.91,;9.59,-34.23,;12.71,-31.61,;11.97,-30.27,;12.84,-29.01,;11.92,-27.78,;10.46,-28.29,;8.99,-27.85,;8.44,-26.4,;6.92,-26.15,;5.95,-27.34,;4.51,-27.89,;5.71,-28.86,;9.2,-25.06,;8.41,-23.74,;9.16,-22.4,;8.37,-21.07,;6.83,-21.09,;6.08,-22.44,;6.87,-23.76,;8.11,-29.11,;6.57,-29.14,;9.04,-30.33,;10.5,-29.82,;14.25,-31.64,;15.05,-30.32,;16.58,-30.34,;15,-32.99,)| Show InChI InChI=1S/C26H35N3O4S/c1-17-25(28(13-18-5-6-18)14-19-7-9-33-10-8-19)26-29(27-17)21(16-34-26)24-22(31-3)11-20(15-30-2)12-23(24)32-4/h11-12,16,18-19H,5-10,13-15H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay				J Med Chem 55: 8450-63 (2012) Article DOI: 10.1021/jm300864p BindingDB Entry DOI: 10.7270/Q2KD202P
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420931 (CHEMBL2087796) Show SMILES COc1cc(C)cc(OC)c1-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(SC)nn12 |(5.46,-3.84,;4.14,-3.05,;2.8,-3.8,;2.78,-5.34,;1.43,-6.1,;1.41,-7.64,;.11,-5.31,;.13,-3.77,;-1.19,-2.98,;-2.54,-3.73,;1.47,-3.02,;1.49,-1.48,;2.84,-.72,;2.86,.82,;1.54,1.6,;.19,.85,;-1.27,1.35,;-1.72,2.82,;-.68,3.95,;.84,3.69,;2.29,4.22,;2.02,2.7,;-3.23,3.16,;-3.6,4.65,;-5.09,5.07,;-5.46,6.56,;-4.36,7.64,;-2.88,7.22,;-2.5,5.72,;-2.19,.11,;-3.73,.13,;-4.48,1.48,;-1.3,-1.15,;.17,-.69,)| Show InChI InChI=1S/C27H35N3O3S/c1-18-14-23(31-2)25(24(15-18)32-3)21-6-5-7-22-26(27(34-4)28-30(21)22)29(16-19-8-9-19)17-20-10-12-33-13-11-20/h5-7,14-15,19-20H,8-13,16-17H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50398580 (CHEMBL2179181) Show SMILES COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCOC4)c(OC)nn23)c(OC)c1 |(35.84,-54.51,;35.1,-53.16,;33.55,-53.14,;32.81,-51.79,;31.27,-51.76,;30.52,-50.42,;28.98,-50.39,;28.18,-51.71,;31.31,-49.1,;30.57,-47.75,;31.44,-46.49,;30.51,-45.26,;29.06,-45.77,;27.58,-45.33,;27.04,-43.88,;25.52,-43.63,;24.55,-44.82,;23.1,-45.37,;24.3,-46.35,;27.79,-42.54,;26.85,-41.32,;27.27,-39.84,;25.99,-38.98,;24.78,-39.92,;25.3,-41.37,;26.7,-46.59,;25.16,-46.62,;24.42,-47.97,;27.63,-47.81,;29.09,-47.31,;32.85,-49.12,;33.64,-47.81,;35.18,-47.83,;33.6,-50.47,)| Show InChI InChI=1S/C25H33N3O5S/c1-29-13-18-9-20(30-2)22(21(10-18)31-3)19-15-34-25-23(24(32-4)26-28(19)25)27(11-16-5-6-16)12-17-7-8-33-14-17/h9-10,15-17H,5-8,11-14H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay				J Med Chem 55: 8450-63 (2012) Article DOI: 10.1021/jm300864p BindingDB Entry DOI: 10.7270/Q2KD202P
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50398578 (CHEMBL2179183 | US8530504, 27) Show SMILES COCCN(CC1CC1)c1c(OC)nn2c(csc12)-c1c(OC)cc(COC)cc1OC |(28.52,-1.59,;26.98,-1.6,;26.23,-2.94,;24.69,-2.96,;23.93,-4.3,;22.41,-4.05,;21.44,-5.25,;19.99,-5.79,;21.19,-6.77,;24.47,-5.75,;23.59,-7.01,;22.06,-7.04,;21.32,-8.39,;24.52,-8.23,;25.98,-7.73,;27.46,-8.17,;28.33,-6.91,;27.4,-5.68,;25.95,-6.19,;28.2,-9.52,;27.42,-10.84,;25.87,-10.81,;25.08,-12.13,;28.16,-12.18,;29.7,-12.21,;30.45,-13.56,;31.99,-13.58,;32.73,-14.93,;30.49,-10.89,;29.74,-9.54,;30.53,-8.23,;32.07,-8.25,)| Show InChI InChI=1S/C23H31N3O5S/c1-27-9-8-25(12-15-6-7-15)21-22(31-5)24-26-17(14-32-23(21)26)20-18(29-3)10-16(13-28-2)11-19(20)30-4/h10-11,14-15H,6-9,12-13H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay				J Med Chem 55: 8450-63 (2012) Article DOI: 10.1021/jm300864p BindingDB Entry DOI: 10.7270/Q2KD202P
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420922 (CHEMBL2087569) Show SMILES CCOCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(CC)nn12 |(4.24,-9.12,;2.9,-8.36,;2.9,-6.82,;1.56,-6.05,;1.56,-4.51,;2.89,-3.74,;2.88,-2.2,;4.21,-1.42,;5.55,-2.19,;1.55,-1.43,;.22,-2.21,;-1.12,-1.44,;-2.45,-2.21,;.22,-3.75,;1.54,.11,;2.87,.88,;2.87,2.42,;1.53,3.19,;.2,2.41,;-1.27,2.89,;-1.75,4.35,;-.72,5.5,;.8,5.26,;2.24,5.82,;2,4.3,;-3.25,4.66,;-3.66,6.15,;-5.15,6.54,;-5.55,8.03,;-4.47,9.12,;-2.98,8.73,;-2.57,7.24,;-2.17,1.64,;-3.71,1.63,;-4.48,2.96,;-1.26,.39,;.21,.87,)| Show InChI InChI=1S/C30H41N3O4/c1-5-24-30(32(18-21-10-11-21)19-22-12-14-37-15-13-22)26-9-7-8-25(33(26)31-24)29-27(34-3)16-23(20-36-6-2)17-28(29)35-4/h7-9,16-17,21-22H,5-6,10-15,18-20H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50398582 (CHEMBL2179179) Show SMILES COCc1cc(OC)c(-c2csc3c(N(CC4CC4)CC4CCCOC4)c(OC)nn23)c(OC)c1 |(37.2,-35.01,;36.46,-33.66,;34.92,-33.64,;34.17,-32.29,;32.63,-32.26,;31.88,-30.92,;30.35,-30.9,;29.55,-32.21,;32.67,-29.6,;31.93,-28.26,;32.8,-26.99,;31.87,-25.77,;30.42,-26.28,;28.94,-25.83,;28.4,-24.39,;26.88,-24.14,;25.91,-25.33,;24.47,-25.88,;25.66,-26.85,;29.16,-23.04,;28.36,-21.72,;29.12,-20.39,;28.33,-19.06,;26.79,-19.08,;26.04,-20.42,;26.82,-21.74,;28.06,-27.09,;26.53,-27.13,;25.79,-28.48,;28.99,-28.32,;30.45,-27.81,;34.21,-29.63,;35,-28.31,;36.54,-28.33,;34.96,-30.98,)| Show InChI InChI=1S/C26H35N3O5S/c1-30-14-19-10-21(31-2)23(22(11-19)32-3)20-16-35-26-24(25(33-4)27-29(20)26)28(12-17-7-8-17)13-18-6-5-9-34-15-18/h10-11,16-18H,5-9,12-15H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay				J Med Chem 55: 8450-63 (2012) Article DOI: 10.1021/jm300864p BindingDB Entry DOI: 10.7270/Q2KD202P
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420920 (CHEMBL2087549 | CHEMBL2087567) Show SMILES CCc1nn2c(cccc2c1N(CC1CC1)CC1CCOCC1)-c1c(OC)cc(COC)cc1OC |(-4.48,2.67,;-3.74,1.32,;-2.2,1.29,;-1.32,.02,;.16,.47,;1.48,-.33,;2.82,.42,;2.86,1.96,;1.54,2.75,;.19,2.01,;-1.27,2.51,;-1.71,3.99,;-.66,5.11,;.86,4.84,;2.3,5.36,;2.03,3.85,;-3.21,4.34,;-3.58,5.83,;-5.06,6.26,;-5.43,7.76,;-4.32,8.82,;-2.84,8.39,;-2.47,6.9,;1.44,-1.87,;2.76,-2.66,;4.11,-1.92,;5.43,-2.72,;2.73,-4.2,;1.38,-4.95,;1.35,-6.49,;2.67,-7.28,;2.64,-8.82,;.07,-4.15,;.1,-2.61,;-1.22,-1.81,;-2.57,-2.56,)| Show InChI InChI=1S/C29H39N3O4/c1-5-23-29(31(17-20-9-10-20)18-21-11-13-36-14-12-21)25-8-6-7-24(32(25)30-23)28-26(34-3)15-22(19-33-2)16-27(28)35-4/h6-8,15-16,20-21H,5,9-14,17-19H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420928 (CHEMBL2087575) Show SMILES COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(C)nn12 |(2.97,-8.96,;2.99,-7.42,;1.67,-6.63,;1.7,-5.09,;3.04,-4.34,;3.06,-2.79,;4.4,-2.05,;5.73,-2.84,;1.74,-2.01,;.39,-2.76,;-.93,-1.97,;-2.28,-2.72,;.37,-4.3,;1.76,-.47,;3.1,.28,;3.13,1.82,;1.8,2.61,;.46,1.86,;-1,2.36,;-1.45,3.83,;-2.93,4.25,;-4.04,3.18,;-5.53,2.8,;-4.46,1.7,;-.41,4.96,;-.86,6.43,;.19,7.56,;-.27,9.03,;-1.77,9.37,;-2.82,8.24,;-2.36,6.77,;-1.92,1.12,;-3.46,1.15,;-1.03,-.13,;.44,.32,)| Show InChI InChI=1S/C28H37N3O4/c1-19-28(30(16-20-8-9-20)17-21-10-12-35-13-11-21)24-7-5-6-23(31(24)29-19)27-25(33-3)14-22(18-32-2)15-26(27)34-4/h5-7,14-15,20-21H,8-13,16-18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated cAMP accumulation after 30 mins by fluo...				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420926 (CHEMBL2087573) Show SMILES COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(OC)nn12 |(2.88,-8.75,;2.88,-7.21,;1.54,-6.44,;1.54,-4.9,;2.87,-4.13,;2.87,-2.59,;4.2,-1.82,;5.54,-2.59,;1.54,-1.82,;.2,-2.59,;-1.13,-1.82,;-2.46,-2.59,;.21,-4.13,;1.53,-.28,;2.87,.49,;2.87,2.03,;1.53,2.8,;.2,2.03,;-1.27,2.5,;-1.74,3.97,;-.71,5.11,;.81,4.87,;2.24,5.43,;2,3.91,;-3.25,4.29,;-3.65,5.77,;-5.14,6.17,;-5.54,7.66,;-4.45,8.75,;-2.96,8.35,;-2.56,6.86,;-2.17,1.26,;-3.71,1.26,;-4.48,2.59,;-1.26,.01,;.2,.49,)| Show InChI InChI=1S/C28H37N3O5/c1-32-18-21-14-24(33-2)26(25(15-21)34-3)22-6-5-7-23-27(28(35-4)29-31(22)23)30(16-19-8-9-19)17-20-10-12-36-13-11-20/h5-7,14-15,19-20H,8-13,16-18H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420929 (CHEMBL2087794) Show SMILES COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(nn12)C#N |(2.63,-8.83,;2.66,-7.29,;1.35,-6.49,;1.38,-4.95,;2.73,-4.21,;2.76,-2.67,;4.11,-1.92,;5.43,-2.72,;1.44,-1.87,;.09,-2.61,;-1.23,-1.81,;-2.57,-2.56,;.06,-4.15,;1.47,-.33,;2.82,.41,;2.85,1.95,;1.54,2.75,;.19,2.01,;-1.27,2.51,;-1.71,3.99,;-.66,5.11,;.86,4.84,;2.31,5.36,;2.03,3.84,;-3.21,4.34,;-3.58,5.83,;-5.06,6.26,;-5.43,7.76,;-4.31,8.83,;-2.84,8.4,;-2.47,6.9,;-2.2,1.29,;-1.32,.02,;.16,.47,;-3.74,1.32,;-5.28,1.35,)| Show InChI InChI=1S/C28H34N4O4/c1-33-18-21-13-25(34-2)27(26(14-21)35-3)23-5-4-6-24-28(22(15-29)30-32(23)24)31(16-19-7-8-19)17-20-9-11-36-12-10-20/h4-6,13-14,19-20H,7-12,16-18H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated cAMP accumulation after 30 mins by fluo...				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50398573 (CHEMBL2179188) Show SMILES CCCCN(C1CCOCC1)c1c(OC)nn2c(csc12)-c1c(OC)cc(COC)cc1OC |(2.77,-37.47,;3.55,-38.8,;5.09,-38.79,;5.85,-37.45,;7.39,-37.45,;8.11,-36.09,;9.66,-36.04,;10.38,-34.69,;9.56,-33.38,;8.02,-33.43,;7.29,-34.79,;7.94,-38.9,;7.06,-40.16,;5.52,-40.19,;4.78,-41.54,;7.99,-41.38,;9.45,-40.88,;10.92,-41.32,;11.8,-40.06,;10.87,-38.83,;9.41,-39.34,;11.67,-42.67,;10.88,-43.99,;9.34,-43.96,;8.54,-45.28,;11.62,-45.33,;13.17,-45.36,;13.91,-46.71,;15.46,-46.74,;16.2,-48.08,;13.96,-44.04,;13.21,-42.69,;14,-41.38,;15.54,-41.4,)| Show InChI InChI=1S/C25H35N3O5S/c1-6-7-10-27(18-8-11-33-12-9-18)23-24(32-5)26-28-19(16-34-25(23)28)22-20(30-3)13-17(15-29-2)14-21(22)31-4/h13-14,16,18H,6-12,15H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by scintillation proximity assay				J Med Chem 55: 8450-63 (2012) Article DOI: 10.1021/jm300864p BindingDB Entry DOI: 10.7270/Q2KD202P
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420929 (CHEMBL2087794) Show SMILES COCc1cc(OC)c(c(OC)c1)-c1cccc2c(N(CC3CC3)CC3CCOCC3)c(nn12)C#N |(2.63,-8.83,;2.66,-7.29,;1.35,-6.49,;1.38,-4.95,;2.73,-4.21,;2.76,-2.67,;4.11,-1.92,;5.43,-2.72,;1.44,-1.87,;.09,-2.61,;-1.23,-1.81,;-2.57,-2.56,;.06,-4.15,;1.47,-.33,;2.82,.41,;2.85,1.95,;1.54,2.75,;.19,2.01,;-1.27,2.51,;-1.71,3.99,;-.66,5.11,;.86,4.84,;2.31,5.36,;2.03,3.84,;-3.21,4.34,;-3.58,5.83,;-5.06,6.26,;-5.43,7.76,;-4.31,8.83,;-2.84,8.4,;-2.47,6.9,;-2.2,1.29,;-1.32,.02,;.16,.47,;-3.74,1.32,;-5.28,1.35,)| Show InChI InChI=1S/C28H34N4O4/c1-33-18-21-13-25(34-2)27(26(14-21)35-3)23-5-4-6-24-28(22(15-29)30-32(23)24)31(16-19-7-8-19)17-20-9-11-36-12-10-20/h4-6,13-14,19-20H,7-12,16-18H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50420910 (CHEMBL2087556) Show SMILES CCCN(CCC)c1c(CC)nn2c(cccc12)-c1ccc(OC)cc1C Show InChI InChI=1S/C23H31N3O/c1-6-14-25(15-7-2)23-20(8-3)24-26-21(10-9-11-22(23)26)19-13-12-18(27-5)16-17(19)4/h9-13,16H,6-8,14-15H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Eisai Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter				J Med Chem 55: 5255-69 (2012) Article DOI: 10.1021/jm300259r BindingDB Entry DOI: 10.7270/Q29P32XC
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 122 total )  |  Next  |  Last  >>

Jump to: