Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM162123 (US9051279, 106) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human MDM2 by TR-FRET assay | J Med Chem 58: 6348-58 (2015) Article DOI: 10.1021/acs.jmedchem.5b00810 BindingDB Entry DOI: 10.7270/Q2HQ41QV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM50229787 ((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human MDM2 by TR-FRET assay | J Med Chem 58: 6348-58 (2015) Article DOI: 10.1021/acs.jmedchem.5b00810 BindingDB Entry DOI: 10.7270/Q2HQ41QV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Canis lupus familiaris) | BDBM50229787 ((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of dog MDM2 by TR-FRET assay | J Med Chem 58: 6348-58 (2015) Article DOI: 10.1021/acs.jmedchem.5b00810 BindingDB Entry DOI: 10.7270/Q2HQ41QV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Mus musculus) | BDBM50229787 ((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of mouse MDM2 by TR-FRET assay | J Med Chem 58: 6348-58 (2015) Article DOI: 10.1021/acs.jmedchem.5b00810 BindingDB Entry DOI: 10.7270/Q2HQ41QV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Canis lupus familiaris) | BDBM162123 (US9051279, 106) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of dog MDM2 by TR-FRET assay | J Med Chem 58: 6348-58 (2015) Article DOI: 10.1021/acs.jmedchem.5b00810 BindingDB Entry DOI: 10.7270/Q2HQ41QV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Mus musculus) | BDBM162123 (US9051279, 106) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 66 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of mouse MDM2 by TR-FRET assay | J Med Chem 58: 6348-58 (2015) Article DOI: 10.1021/acs.jmedchem.5b00810 BindingDB Entry DOI: 10.7270/Q2HQ41QV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50040929 (4,5-dianilinophthalimide | 5,6-bis(phenylamino)-1H...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | PubMed | 160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Ciba-Geigy Limited Curated by ChEMBL | Assay Description Competitive inhibition of ATP binding to EGF-R | J Med Chem 37: 1015-27 (1994) BindingDB Entry DOI: 10.7270/Q2M32TTP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Casein kinase II subunit alpha (Homo sapiens (Human)) | BDBM11319 ((5-oxo-5,6-dihydroindolo[1,2-a]quinazolin-7-yl)ace...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem | Article PubMed | 170 | -38.2 | 390 | n/a | n/a | n/a | n/a | 7.5 | 22 |
University of Padova | Assay Description In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam... | Biochem J 374: 639-46 (2003) Article DOI: 10.1042/BJ20030674 BindingDB Entry DOI: 10.7270/Q2BV7DTQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Casein kinase II subunit alpha (Homo sapiens (Human)) | BDBM11323 (4,5,6,7-tetrabromo-1H-1,2,3-benzotriazole | 4,5,6,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents | PDB Article PubMed | 400 | -36.2 | 500 | n/a | n/a | n/a | n/a | 7.5 | 22 |
University of Padova | Assay Description In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam... | Biochem J 374: 639-46 (2003) Article DOI: 10.1042/BJ20030674 BindingDB Entry DOI: 10.7270/Q2BV7DTQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Casein kinase II subunit alpha (Homo sapiens (Human)) | BDBM7458 (5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 740 | -34.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
University of Padova | Assay Description In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam... | Biochem J 374: 639-46 (2003) Article DOI: 10.1042/BJ20030674 BindingDB Entry DOI: 10.7270/Q2BV7DTQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Casein kinase II subunit alpha (Homo sapiens (Human)) | BDBM7460 (2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | 1.18E+3 | -33.5 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
University of Padova | Assay Description In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam... | Biochem J 374: 639-46 (2003) Article DOI: 10.1042/BJ20030674 BindingDB Entry DOI: 10.7270/Q2BV7DTQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Casein kinase II subunit alpha (Homo sapiens (Human)) | BDBM11318 (1,3,8-trihydroxy-6-methyl-9,10-dihydroanthracene-9...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 1.85E+3 | -32.4 | 890 | n/a | n/a | n/a | n/a | 7.5 | 22 |
University of Padova | Assay Description In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam... | Biochem J 374: 639-46 (2003) Article DOI: 10.1042/BJ20030674 BindingDB Entry DOI: 10.7270/Q2BV7DTQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Casein kinase II subunit alpha (Homo sapiens (Human)) | BDBM11324 ((2R,3R,4S,5R)-2-(5,6-dichloro-1H-1,3-benzodiazol-1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 4.50E+3 | -30.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
University of Padova | Assay Description In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam... | Biochem J 374: 639-46 (2003) Article DOI: 10.1042/BJ20030674 BindingDB Entry DOI: 10.7270/Q2BV7DTQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Growth factor receptor-bound protein 2 (Homo sapiens (Human)) | BDBM50064333 (CHEMBL49860 | Phosphoric acid mono-(2-amino-4-{2-a...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of binding to Growth factor receptor bound protein 2 (Grb2) SH2 domain | J Med Chem 41: 1741-4 (1998) Article DOI: 10.1021/jm970856n BindingDB Entry DOI: 10.7270/Q2M32TWK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129810 (US8815926, 89) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129937 (US8815926, 218) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM130042 (US8815926, 325) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0590 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236338 (US9365576, 91) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0610 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236270 (US9365576, 23) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0650 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM143673 (US8969341, 180) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0680 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236261 (US9365576, 14) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0680 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236476 (US9365576, 232) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0690 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129738 (US8815926, 17) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129796 (US8815926, 75) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129730 (US8815926, 9) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236471 (US9365576, 227) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0710 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM50467282 (CHEMBL4290086) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0740 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of Cy5-labeled p53 derived TFSDLWKLL peptide binding to C-terminal biotin-labelled human MDM2 (2 to 188 residues) by TR-FRET assay | Bioorg Med Chem Lett 28: 3404-3408 (2018) Article DOI: 10.1016/j.bmcl.2018.08.027 BindingDB Entry DOI: 10.7270/Q2C82D0H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236267 (US9365576, 20) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0750 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236473 (US9365576, 229) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0780 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236435 (US9365576, 188) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0790 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129892 (US8815926, 173) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129945 (US8815926, 226) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129947 (US8815926, 228) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129966 (US8815926, 247) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236336 (US9365576, 89) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129796 (US8815926, 75) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of Cy5-labeled p53 derived TFSDLWKLL peptide binding to C-terminal biotin-labelled human MDM2 (2 to 188 residues) by TR-FRET assay | Bioorg Med Chem Lett 28: 3404-3408 (2018) Article DOI: 10.1016/j.bmcl.2018.08.027 BindingDB Entry DOI: 10.7270/Q2C82D0H | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM130000 (US8815926, 281) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0810 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236368 (US9365576, 121 | US9365576, 218) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0870 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM130035 (US8815926, 317) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0890 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129737 (US8815926, 16) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129928 (US8815926, 209) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129942 (US8815926, 223) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129838 (US8815926, 117) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet-derived growth factor receptor alpha (Homo sapiens (Human)) | BDBM50191945 (CHEMBL3904768) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes of Biomedical Research (NIBR) Curated by ChEMBL | Assay Description Inhibition of PDGFRalpha kinase domain (unknown origin) assessed as reduction in probe peptide substrate phosphorylation by capillary electrophoresis | J Med Chem 59: 7901-14 (2016) Article DOI: 10.1021/acs.jmedchem.6b00703 BindingDB Entry DOI: 10.7270/Q25X2BW1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236279 (US9365576, 32) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0940 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cellular tumor antigen p53 [18-26]/E3 ubiquitin-protein ligase Mdm2 [2-188] (Homo sapiens (Human)) | BDBM236265 (US9365576, 18) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.0950 | n/a | n/a | n/a | n/a | n/a | 25 |
Novartis AG US Patent | Assay Description Assay 2: The test is performed in white 384-well plates (Greiner Bio-One, reference 781207) in a total volume of 60 μL by adding 1 μL of compou... | US Patent US9365576 (2016) BindingDB Entry DOI: 10.7270/Q2DN43XR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM143676 (US8969341, 183) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB US Patent | n/a | n/a | 0.0970 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129884 (US8815926, 164) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human)) | BDBM129894 (US8815926, 175) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8815926 (2014) BindingDB Entry DOI: 10.7270/Q29P309G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase ABL1 [64-515] (Homo sapiens (Human)) | BDBM230809 (US9340537, 63 | US9896444, Example 63) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
IRBM-MRL | Assay Description Radio ABL1 (64-515) Assay: For determination of ABL kinase activity, the radiometric filter-binding assay was used. The assay was performed by mixing... | J Med Chem 50: 4953-75 (2007) BindingDB Entry DOI: 10.7270/Q2B27XKV | |||||||||||
More data for this Ligand-Target Pair |
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