Compile Data Set for Download or QSAR

Found 3117 hits with Last Name = 'gosmini' and Initial = 'rl'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM379774 (US9926281, Compound 279 | US9926281, Compound 448) Show SMILES COCC1(CC(C)C(=O)N2CCN(CC2)c2cc(F)c(Cl)c(F)c2)NC(=O)NC1=O Show InChI InChI=1S/C19H23ClF2N4O4/c1-11(9-19(10-30-2)17(28)23-18(29)24-19)16(27)26-5-3-25(4-6-26)12-7-13(21)15(20)14(22)8-12/h7-8,11H,3-6,9-10H2,1-2H3,(H2,23,24,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
ADAMTS5 (Rattus norvegicus (Rat))	BDBM379670 (US9926281, Compound 194 | US9926281, Compound 413) Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN([C@@H](C)C1)c1cc(F)cc(Cl)c1 |r| Show InChI InChI=1S/C21H26ClFN4O3/c1-12(10-21(14-3-4-14)19(29)24-20(30)25-21)18(28)26-5-6-27(13(2)11-26)17-8-15(22)7-16(23)9-17/h7-9,12-14H,3-6,10-11H2,1-2H3,(H2,24,25,29,30)/t12?,13-,21?/m0/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
ADAMTS5 (Rattus norvegicus (Rat))	BDBM379686 (US9926281, Compound 212) Show SMILES C[C@@H](C[C@]1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN([C@@H](C)C1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C21H26F2N4O3/c1-12(10-21(14-3-4-14)19(29)24-20(30)25-21)18(28)26-7-8-27(13(2)11-26)15-5-6-16(22)17(23)9-15/h5-6,9,12-14H,3-4,7-8,10-11H2,1-2H3,(H2,24,25,29,30)/t12-,13-,21-/m0/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
Collagenase 3 (Homo sapiens (Human))	BDBM379776 (US9926281, Compound 234) Show SMILES CC(CC1(NC(=O)NC1=O)C1CN(C1)C(=O)OC(C)(C)C)C(=O)N1CCN(CC1)c1ccc(F)c(F)c1 Show InChI InChI=1S/C25H33F2N5O5/c1-15(20(33)31-9-7-30(8-10-31)17-5-6-18(26)19(27)11-17)12-25(21(34)28-22(35)29-25)16-13-32(14-16)23(36)37-24(2,3)4/h5-6,11,15-16H,7-10,12-14H2,1-4H3,(H2,28,29,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description MMP-13:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP13 (Chemicon, Cat #CC06...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
ADAMTS5 (Rattus norvegicus (Rat))	BDBM379681 (US9926281, Compound 207 | US9926281, Compound 416) Show SMILES C[C@H]1CN(CCN1c1ccc(Cl)c(Cl)c1)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1 |r| Show InChI InChI=1S/C20H24Cl2N4O3/c1-12-11-25(8-9-26(12)14-4-5-15(21)16(22)10-14)17(27)6-7-20(13-2-3-13)18(28)23-19(29)24-20/h4-5,10,12-13H,2-3,6-9,11H2,1H3,(H2,23,24,28,29)/t12-,20-/m0/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
ADAMTS5 (Rattus norvegicus (Rat))	BDBM379668 (US9926281, Compound 192 | US9926281, Compound 411) Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN([C@@H](C)C1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C21H26ClFN4O3/c1-12(10-21(14-3-4-14)19(29)24-20(30)25-21)18(28)26-7-8-27(13(2)11-26)15-5-6-17(23)16(22)9-15/h5-6,9,12-14H,3-4,7-8,10-11H2,1-2H3,(H2,24,25,29,30)/t12?,13-,21?/m0/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
ADAMTS5 (Rattus norvegicus (Rat))	BDBM379653 (US9926281, Compound 176) Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN(CC1)c1cccc(Cl)c1C Show InChI InChI=1S/C21H27ClN4O3/c1-13(12-21(15-6-7-15)19(28)23-20(29)24-21)18(27)26-10-8-25(9-11-26)17-5-3-4-16(22)14(17)2/h3-5,13,15H,6-12H2,1-2H3,(H2,23,24,28,29)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM379901 (US9926281, Compound 396) Show SMILES C[C@H]1CN(CCN1c1cc(F)cc(F)c1)C(=O)CCC1(NC(=O)NC1=O)c1nc(C)oc1C |r| Show InChI InChI=1S/C22H25F2N5O4/c1-12-11-28(6-7-29(12)17-9-15(23)8-16(24)10-17)18(30)4-5-22(20(31)26-21(32)27-22)19-13(2)33-14(3)25-19/h8-10,12H,4-7,11H2,1-3H3,(H2,26,27,31,32)/t12-,22?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description MMP-14:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP14 (Biomol, Cat #SE-259...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
Matrix metalloproteinase-14 (Homo sapiens (Human))	BDBM379776 (US9926281, Compound 234) Show SMILES CC(CC1(NC(=O)NC1=O)C1CN(C1)C(=O)OC(C)(C)C)C(=O)N1CCN(CC1)c1ccc(F)c(F)c1 Show InChI InChI=1S/C25H33F2N5O5/c1-15(20(33)31-9-7-30(8-10-31)17-5-6-18(26)19(27)11-17)12-25(21(34)28-22(35)29-25)16-13-32(14-16)23(36)37-24(2,3)4/h5-6,11,15-16H,7-10,12-14H2,1-4H3,(H2,28,29,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description MMP-14:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat # AS-27076) by human MMP14 (Biomol, Cat #SE-259...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
ADAMTS5 (Rattus norvegicus (Rat))	BDBM379669 (US9926281, Compound 193 | US9926281, Compound 412) Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN([C@@H](C)C1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C21H27ClN4O3/c1-13(11-21(15-3-4-15)19(28)23-20(29)24-21)18(27)25-9-10-26(14(2)12-25)17-7-5-16(22)6-8-17/h5-8,13-15H,3-4,9-12H2,1-2H3,(H2,23,24,28,29)/t13?,14-,21?/m0/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
ADAMTS5 (Rattus norvegicus (Rat))	BDBM379645 (US9926281, Compound 167 | US9926281, Compound 408) Show SMILES C[C@H]1CN(CCN1c1ccc(Cl)c(Cl)c1)C(=O)CCC1(NC(=O)NC1=O)C1CC1 |r| Show InChI InChI=1S/C20H24Cl2N4O3/c1-12-11-25(8-9-26(12)14-4-5-15(21)16(22)10-14)17(27)6-7-20(13-2-3-13)18(28)23-19(29)24-20/h4-5,10,12-13H,2-3,6-9,11H2,1H3,(H2,23,24,28,29)/t12-,20?/m0/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM379668 (US9926281, Compound 192 | US9926281, Compound 411) Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN([C@@H](C)C1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C21H26ClFN4O3/c1-12(10-21(14-3-4-14)19(29)24-20(30)25-21)18(28)26-7-8-27(13(2)11-26)15-5-6-17(23)16(22)9-15/h5-6,9,12-14H,3-4,7-8,10-11H2,1-2H3,(H2,24,25,29,30)/t12?,13-,21?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM379670 (US9926281, Compound 194 | US9926281, Compound 413) Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN([C@@H](C)C1)c1cc(F)cc(Cl)c1 |r| Show InChI InChI=1S/C21H26ClFN4O3/c1-12(10-21(14-3-4-14)19(29)24-20(30)25-21)18(28)26-5-6-27(13(2)11-26)17-8-15(22)7-16(23)9-17/h7-9,12-14H,3-6,10-11H2,1-2H3,(H2,24,25,29,30)/t12?,13-,21?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
ADAMTS5 (Rattus norvegicus (Rat))	BDBM379667 (US9926281, Compound 191) Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN([C@@H](C)C1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C21H26F2N4O3/c1-12(10-21(14-3-4-14)19(29)24-20(30)25-21)18(28)26-7-8-27(13(2)11-26)15-5-6-16(22)17(23)9-15/h5-6,9,12-14H,3-4,7-8,10-11H2,1-2H3,(H2,24,25,29,30)/t12?,13-,21?/m0/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM379670 (US9926281, Compound 194 | US9926281, Compound 413) Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN([C@@H](C)C1)c1cc(F)cc(Cl)c1 |r| Show InChI InChI=1S/C21H26ClFN4O3/c1-12(10-21(14-3-4-14)19(29)24-20(30)25-21)18(28)26-5-6-27(13(2)11-26)17-8-15(22)7-16(23)9-17/h7-9,12-14H,3-6,10-11H2,1-2H3,(H2,24,25,29,30)/t12?,13-,21?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
ADAMTS5 (Rattus norvegicus (Rat))	BDBM379649 (US9926281, Compound 172 | US9926281, Compound 409) Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN(CC1)c1cc(Cl)cc(Cl)c1 Show InChI InChI=1S/C20H24Cl2N4O3/c1-12(11-20(13-2-3-13)18(28)23-19(29)24-20)17(27)26-6-4-25(5-7-26)16-9-14(21)8-15(22)10-16/h8-10,12-13H,2-7,11H2,1H3,(H2,23,24,28,29)	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM379668 (US9926281, Compound 192 | US9926281, Compound 411) Show SMILES CC(CC1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN([C@@H](C)C1)c1ccc(F)c(Cl)c1 |r| Show InChI InChI=1S/C21H26ClFN4O3/c1-12(10-21(14-3-4-14)19(29)24-20(30)25-21)18(28)26-7-8-27(13(2)11-26)15-5-6-17(23)16(22)9-15/h5-6,9,12-14H,3-4,7-8,10-11H2,1-2H3,(H2,24,25,29,30)/t12?,13-,21?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
ADAMTS5 (Rattus norvegicus (Rat))	BDBM379678 (US9926281, Compound 204) Show SMILES C[C@H]1CN(CCN1c1cc(Cl)cc(Cl)c1)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1 |r| Show InChI InChI=1S/C20H24Cl2N4O3/c1-12-11-25(6-7-26(12)16-9-14(21)8-15(22)10-16)17(27)4-5-20(13-2-3-13)18(28)23-19(29)24-20/h8-10,12-13H,2-7,11H2,1H3,(H2,23,24,28,29)/t12-,20-/m0/s1	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-4:The basis for the assay is the cleavage of the substrate TBIS-1 (5-FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMTS4For the do...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM379681 (US9926281, Compound 207 | US9926281, Compound 416) Show SMILES C[C@H]1CN(CCN1c1ccc(Cl)c(Cl)c1)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1 |r| Show InChI InChI=1S/C20H24Cl2N4O3/c1-12-11-25(8-9-26(12)14-4-5-15(21)16(22)10-14)17(27)6-7-20(13-2-3-13)18(28)23-19(29)24-20/h4-5,10,12-13H,2-3,6-9,11H2,1H3,(H2,23,24,28,29)/t12-,20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM379681 (US9926281, Compound 207 | US9926281, Compound 416) Show SMILES C[C@H]1CN(CCN1c1ccc(Cl)c(Cl)c1)C(=O)CC[C@]1(NC(=O)NC1=O)C1CC1 |r| Show InChI InChI=1S/C20H24Cl2N4O3/c1-12-11-25(8-9-26(12)14-4-5-15(21)16(22)10-14)17(27)6-7-20(13-2-3-13)18(28)23-19(29)24-20/h4-5,10,12-13H,2-3,6-9,11H2,1H3,(H2,23,24,28,29)/t12-,20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM379686 (US9926281, Compound 212) Show SMILES C[C@@H](C[C@]1(NC(=O)NC1=O)C1CC1)C(=O)N1CCN([C@@H](C)C1)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C21H26F2N4O3/c1-12(10-21(14-3-4-14)19(29)24-20(30)25-21)18(28)26-7-8-27(13(2)11-26)15-5-6-16(22)17(23)9-15/h5-6,9,12-14H,3-4,7-8,10-11H2,1-2H3,(H2,24,25,29,30)/t12-,13-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q27S7R3T
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429789 (5-[3-[4-(4- chloro-3- methoxy-5- methyl- phenyl)-1...) Show SMILES COc1cc(cc(C)c1Cl)C1CCN(CC1)C(=O)[C@@H](C)C[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C21H28ClN3O4/c1-12-9-15(10-16(29-4)17(12)22)14-5-7-25(8-6-14)18(26)13(2)11-21(3)19(27)23-20(28)24-21/h9-10,13-14H,5-8,11H2,1-4H3,(H2,23,24,27,28)/t13-,21+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429790 (5-[3-[4-(4- chloro-3- methoxy-5- methyl- phenyl)-1...) Show SMILES COC[C@]1(C[C@H](C)C(=O)N2CCC(CC2)c2cc(C)c(Cl)c(OC)c2)NC(=O)NC1=O |r| Show InChI InChI=1S/C22H30ClN3O5/c1-13-9-16(10-17(31-4)18(13)23)15-5-7-26(8-6-15)19(27)14(2)11-22(12-30-3)20(28)24-21(29)25-22/h9-10,14-15H,5-8,11-12H2,1-4H3,(H2,24,25,28,29)/t14-,22-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429791 ((5R)-5-[3-[4- (4-chloro-3- methoxy-5- methyl- phen...) Show SMILES COc1cc(cc(C)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24ClN3O4/c1-11-9-13(10-15(27-2)17(11)20)12-5-7-23(8-6-12)16(24)4-3-14-18(25)22-19(26)21-14/h9-10,12,14H,3-8H2,1-2H3,(H2,21,22,25,26)/t14-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 5 (Homo sapiens (Human))	BDBM429779 (5-[3-[4-(4- chloro-3- fluoro-5- methoxy- phenyl)-1...) Show SMILES COC[C@]1(C[C@H](C)C(=O)N2CCC(CC2)c2cc(F)c(Cl)c(OC)c2)NC(=O)NC1=O |r| Show InChI InChI=1S/C21H27ClFN3O5/c1-12(10-21(11-30-2)19(28)24-20(29)25-21)18(27)26-6-4-13(5-7-26)14-8-15(23)17(22)16(9-14)31-3/h8-9,12-13H,4-7,10-11H2,1-3H3,(H2,24,25,28,29)/t12-,21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For the dose res...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429688 ((R)-5-(3-(4-(4- chloro-3,5- dimethoxy- phenyl)pipe...) Show SMILES COc1cc(cc(OC)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24ClN3O5/c1-27-14-9-12(10-15(28-2)17(14)20)11-5-7-23(8-6-11)16(24)4-3-13-18(25)22-19(26)21-13/h9-11,13H,3-8H2,1-2H3,(H2,21,22,25,26)/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429689 (5-(3-(4-(4- chloro-3,5- dimethoxy- phenyl)piperidi...) Show SMILES COc1cc(cc(OC)c1Cl)C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C20H26ClN3O5/c1-20(18(26)22-19(27)23-20)7-4-16(25)24-8-5-12(6-9-24)13-10-14(28-2)17(21)15(11-13)29-3/h10-12H,4-9H2,1-3H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429691 (5-(3-(4-(4- chlorophenyl) piperidin-1- yl)-2-methy...) Show SMILES C[C@@H](C[C@@]1(C)NC(=O)NC1=O)C(=O)N1CCC(CC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C19H24ClN3O3/c1-12(11-19(2)17(25)21-18(26)22-19)16(24)23-9-7-14(8-10-23)13-3-5-15(20)6-4-13/h3-6,12,14H,7-11H2,1-2H3,(H2,21,22,25,26)/t12-,19+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429692 (5-(3-(4-(3,5- dichlorophenyl) piperidin-1- yl)-2-m...) Show SMILES C[C@@H](C[C@@]1(C)NC(=O)NC1=O)C(=O)N1CCC(CC1)c1cc(Cl)cc(Cl)c1 |r| Show InChI InChI=1S/C19H23Cl2N3O3/c1-11(10-19(2)17(26)22-18(27)23-19)16(25)24-5-3-12(4-6-24)13-7-14(20)9-15(21)8-13/h7-9,11-12H,3-6,10H2,1-2H3,(H2,22,23,26,27)/t11-,19+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429715 (5-(3-(4-(4- chloro-3- methoxyl- phenyl)piperidin-1...) Show SMILES COc1cc(ccc1Cl)C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H24ClN3O4/c1-19(17(25)21-18(26)22-19)8-5-16(24)23-9-6-12(7-10-23)13-3-4-14(20)15(11-13)27-2/h3-4,11-12H,5-10H2,1-2H3,(H2,21,22,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429716 (5-(3-(4-(4- chloro-5- methoxy-2- methylphenyl) pip...) Show SMILES COc1cc(C2CCN(CC2)C(=O)CCC2(C)NC(=O)NC2=O)c(C)cc1Cl Show InChI InChI=1S/C20H26ClN3O4/c1-12-10-15(21)16(28-3)11-14(12)13-5-8-24(9-6-13)17(25)4-7-20(2)18(26)22-19(27)23-20/h10-11,13H,4-9H2,1-3H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429723 (5-(3-(4-(4- chloro-2- methoxyphenyl) piperidin-1- ...) Show SMILES COc1cc(Cl)ccc1C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H24ClN3O4/c1-19(17(25)21-18(26)22-19)8-5-16(24)23-9-6-12(7-10-23)14-4-3-13(20)11-15(14)27-2/h3-4,11-12H,5-10H2,1-2H3,(H2,21,22,25,26)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429724 (5-(3-(4-(3,4- difluoro-5- methoxyphenyl) piperidin...) Show SMILES COc1cc(cc(F)c1F)C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H23F2N3O4/c1-19(17(26)22-18(27)23-19)6-3-15(25)24-7-4-11(5-8-24)12-9-13(20)16(21)14(10-12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429725 ((R)-5-(3-(4-(4- chloro-3- fluoro-5- methoxyphenyl)...) Show SMILES COc1cc(cc(F)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C18H21ClFN3O4/c1-27-14-9-11(8-12(20)16(14)19)10-4-6-23(7-5-10)15(24)3-2-13-17(25)22-18(26)21-13/h8-10,13H,2-7H2,1H3,(H2,21,22,25,26)/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429726 (5-(3-(4-(4- chloro-3- fluoro-5- methoxyphenyl) pip...) Show SMILES COc1cc(cc(F)c1Cl)C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H23ClFN3O4/c1-19(17(26)22-18(27)23-19)6-3-15(25)24-7-4-11(5-8-24)12-9-13(21)16(20)14(10-12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429740 ((R)-5-(3-(4- (4,5-dichloro- 2- methoxyphenyl) pipe...) Show SMILES COc1cc(Cl)c(Cl)cc1C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C18H21Cl2N3O4/c1-27-15-9-13(20)12(19)8-11(15)10-4-6-23(7-5-10)16(24)3-2-14-17(25)22-18(26)21-14/h8-10,14H,2-7H2,1H3,(H2,21,22,25,26)/t14-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429741 (5-(3-(4-(4,5- dichloro-2- methoxyphenyl) piperidin...) Show SMILES COc1cc(Cl)c(Cl)cc1C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H23Cl2N3O4/c1-19(17(26)22-18(27)23-19)6-3-16(25)24-7-4-11(5-8-24)12-9-13(20)14(21)10-15(12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429745 ((R)-5-(3-(4-(3- chloro-5- methoxyphenyl) piperidin...) Show SMILES COc1cc(Cl)cc(c1)C1CCN(CC1)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24ClN3O4/c1-19(17(25)21-18(26)22-19)6-3-16(24)23-7-4-12(5-8-23)13-9-14(20)11-15(10-13)27-2/h9-12H,3-8H2,1-2H3,(H2,21,22,25,26)/t19-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429747 ((R)-5-(3-(4- (3,4-dichloro-5- methoxyphenyl) piper...) Show SMILES COc1cc(cc(Cl)c1Cl)C1CCN(CC1)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H23Cl2N3O4/c1-19(17(26)22-18(27)23-19)6-3-15(25)24-7-4-11(5-8-24)12-9-13(20)16(21)14(10-12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)/t19-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429748 ((R)-5-(3-(4- (3,4-dichloro-5- methoxyphenyl) piper...) Show SMILES COc1cc(cc(Cl)c1Cl)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C18H21Cl2N3O4/c1-27-14-9-11(8-12(19)16(14)20)10-4-6-23(7-5-10)15(24)3-2-13-17(25)22-18(26)21-13/h8-10,13H,2-7H2,1H3,(H2,21,22,25,26)/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429750 (5-(3-(4-(4,5- dichloro-2- methylphenyl) piperidin-...) Show SMILES Cc1cc(Cl)c(Cl)cc1C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H23Cl2N3O3/c1-11-9-14(20)15(21)10-13(11)12-4-7-24(8-5-12)16(25)3-6-19(2)17(26)22-18(27)23-19/h9-10,12H,3-8H2,1-2H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429751 (5-(3-(4-(4- fluoro-3,5- dimethoxyphenyl) piperidin...) Show SMILES COc1cc(cc(OC)c1F)C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C20H26FN3O5/c1-20(18(26)22-19(27)23-20)7-4-16(25)24-8-5-12(6-9-24)13-10-14(28-2)17(21)15(11-13)29-3/h10-12H,4-9H2,1-3H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429752 (5-(3-(4-(3- chloro-4- fluoro-5- methoxyphenyl) pip...) Show SMILES COc1cc(cc(Cl)c1F)C1CCN(CC1)C(=O)CCC1(C)NC(=O)NC1=O Show InChI InChI=1S/C19H23ClFN3O4/c1-19(17(26)22-18(27)23-19)6-3-15(25)24-7-4-11(5-8-24)12-9-13(20)16(21)14(10-12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429758 ((5R)-5-[3-[4- (4-chloro-2- methoxy- phenyl)-1- pip...) Show SMILES COc1cc(Cl)ccc1C1CCN(CC1)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24ClN3O4/c1-19(17(25)21-18(26)22-19)8-5-16(24)23-9-6-12(7-10-23)14-4-3-13(20)11-15(14)27-2/h3-4,11-12H,5-10H2,1-2H3,(H2,21,22,25,26)/t19-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429759 ((5R)-5-[3-[4- (3-chloro-4- fluoro-5- methoxy- phen...) Show SMILES COc1cc(cc(Cl)c1F)C1CCN(CC1)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H23ClFN3O4/c1-19(17(26)22-18(27)23-19)6-3-15(25)24-7-4-11(5-8-24)12-9-13(20)16(21)14(10-12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)/t19-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429760 ((5R)-5-[3-[4- (4-fluoro-3,5- dimethoxy- phenyl)-1-...) Show SMILES COc1cc(cc(OC)c1F)C1CCN(CC1)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C20H26FN3O5/c1-20(18(26)22-19(27)23-20)7-4-16(25)24-8-5-12(6-9-24)13-10-14(28-2)17(21)15(11-13)29-3/h10-12H,4-9H2,1-3H3,(H2,22,23,26,27)/t20-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429761 ((5R)-5-[3-[4- (4-fluoro-3,5- dimethoxy- phenyl)-1-...) Show SMILES COc1cc(cc(OC)c1F)C1CCN(CC1)C(=O)CC[C@H]1NC(=O)NC1=O |r| Show InChI InChI=1S/C19H24FN3O5/c1-27-14-9-12(10-15(28-2)17(14)20)11-5-7-23(8-6-11)16(24)4-3-13-18(25)22-19(26)21-13/h9-11,13H,3-8H2,1-2H3,(H2,21,22,25,26)/t13-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM429763 ((5R)-5-[3-[4- (4-chloro-3- fluoro-5- methoxy- phen...) Show SMILES COc1cc(cc(F)c1Cl)C1CCN(CC1)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H23ClFN3O4/c1-19(17(26)22-18(27)23-19)6-3-15(25)24-7-4-11(5-8-24)12-9-13(21)16(20)14(10-12)28-2/h9-11H,3-8H2,1-2H3,(H2,22,23,26,27)/t19-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...				US Patent US10550100 (2020) BindingDB Entry DOI: 10.7270/Q2D2211N
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471828 ((5S)-5-[(2S)-3-[4- (3,4-difluoro-5- methoxy- pheny...) Show SMILES COc1cc(cc(F)c1F)N1CCN(CC1)C(=O)[C@@H](C)C[C@]1(NC(=O)NC1=O)c1ccccn1 |r| Show InChI InChI=1S/C23H25F2N5O4/c1-14(13-23(18-5-3-4-6-26-18)21(32)27-22(33)28-23)20(31)30-9-7-29(8-10-30)15-11-16(24)19(25)17(12-15)34-2/h3-6,11-12,14H,7-10,13H2,1-2H3,(H2,27,28,32,33)/t14-,23-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair
A disintegrin and metalloproteinase with thrombospondin motifs 6 (Human)	BDBM471829 ((5R)-5-[3-[(3S)-4- (4-chloro-3- methoxy-phenyl)- 3...) Show SMILES COc1cc(ccc1Cl)N1CCN(C[C@@H]1C)C(=O)CC[C@@]1(C)NC(=O)NC1=O |r| Show InChI InChI=1S/C19H25ClN4O4/c1-12-11-23(16(25)6-7-19(2)17(26)21-18(27)22-19)8-9-24(12)13-4-5-14(20)15(10-13)28-3/h4-5,10,12H,6-9,11H2,1-3H3,(H2,21,22,26,27)/t12-,19+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.5	n/a	n/a	n/a	n/a	n/a	n/a
GALAPAGOS NV US Patent					Assay Description TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...				US Patent US10829478 (2020) BindingDB Entry DOI: 10.7270/Q2X351H2
					More data for this Ligand-Target Pair

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