Found 383 hits with Last Name = 'green' and Initial = 'mj' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histamine H3 receptor
(GUINEA PIG) | BDBM50034711
((1R,2S)-2-(1H-Imidazol-4-yl)-1-methyl-propylamine ...)Show InChI InChI=1S/C7H13N3/c1-5(6(2)8)7-3-9-4-10-7/h3-6H,8H2,1-2H3,(H,9,10)/t5-,6+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 0.800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Binding afinity against Histamine H3 receptor |
J Med Chem 38: 1593-9 (1995)
BindingDB Entry DOI: 10.7270/Q2BK1BC1 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM50071491
(4-(1H-Imidazol-4-yl)-butyramidine | CHEMBL72156 | ...)Show InChI InChI=1S/C7H12N4/c8-7(9)3-1-2-6-4-10-5-11-6/h4-5H,1-3H2,(H3,8,9)(H,10,11) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of N-alpha-methylhistamine binding to histamine H3 receptor of guinea pig brain membranes |
Bioorg Med Chem Lett 8: 2263-8 (1999)
BindingDB Entry DOI: 10.7270/Q2TD9WH3 |
More data for this Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50189939
(5-(4-amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-6-hydrox...)Show SMILES Nc1nccc2[nH]c(cc12)-c1cc(cc(-c2cccc(CNC(=O)[C@@H](O)Cc3ccccc3)c2)c1O)C(O)=O Show InChI InChI=1S/C30H26N4O5/c31-28-23-15-25(34-24(23)9-10-32-28)22-14-20(30(38)39)13-21(27(22)36)19-8-4-7-18(11-19)16-33-29(37)26(35)12-17-5-2-1-3-6-17/h1-11,13-15,26,34-36H,12,16H2,(H2,31,32)(H,33,37)(H,38,39)/t26-/m0/s1 | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description Binding affinity to f7a/TF complex |
Bioorg Med Chem Lett 16: 4567-70 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.016 BindingDB Entry DOI: 10.7270/Q2NG4Q67 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM22904
((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1 | PDB
UniProtKB/SwissProt
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| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Binding afinity against Histamine H3 receptor |
J Med Chem 38: 1593-9 (1995)
BindingDB Entry DOI: 10.7270/Q2BK1BC1 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM22904
((2R)-1-(1H-imidazol-5-yl)propan-2-amine | (R)-alph...)Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1 | PDB
UniProtKB/SwissProt
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| Purchase
CHEMBL MCE PC cid PC sid UniChem
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| PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Binding affinity of compound towards Histamine H3 receptor was determined in guinea pig brain tissue using [3H]- N alpha-methylhistamine radioligand |
Bioorg Med Chem Lett 8: 243-8 (1999)
BindingDB Entry DOI: 10.7270/Q2ST7P0Z |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187167
(CHEMBL211357 | N-[(S)-5-amino-1-(5-{4-[2-(3-chloro...)Show SMILES NCCCC[C@H](NC(=O)c1cc(F)cc(F)c1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(Cl)c2)n1 Show InChI InChI=1S/C31H30ClF2N5O4/c32-23-5-3-4-19(14-23)11-13-36-30(41)21-9-7-20(8-10-21)15-27-38-29(39-43-27)28(40)26(6-1-2-12-35)37-31(42)22-16-24(33)18-25(34)17-22/h3-5,7-10,14,16-18,26H,1-2,6,11-13,15,35H2,(H,36,41)(H,37,42)/t26-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187177
(CHEMBL212774 | N-[(2S)-6-amino-1-{5-[(4-{[2-(3-chl...)Show SMILES NCCCC[C@H](NC(=O)c1cccc(F)c1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(Cl)c2)n1 Show InChI InChI=1S/C31H31ClFN5O4/c32-24-7-3-5-20(17-24)14-16-35-30(40)22-12-10-21(11-13-22)18-27-37-29(38-42-27)28(39)26(9-1-2-15-34)36-31(41)23-6-4-8-25(33)19-23/h3-8,10-13,17,19,26H,1-2,9,14-16,18,34H2,(H,35,40)(H,36,41)/t26-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187166
(CHEMBL380293 | N-[(S)-5-amino-1-(5-{4-[2-(3-chloro...)Show SMILES NCCCC[C@H](NC(=O)c1ccc(F)c(F)c1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(Cl)c2)n1 Show InChI InChI=1S/C31H30ClF2N5O4/c32-23-5-3-4-19(16-23)13-15-36-30(41)21-9-7-20(8-10-21)17-27-38-29(39-43-27)28(40)26(6-1-2-14-35)37-31(42)22-11-12-24(33)25(34)18-22/h3-5,7-12,16,18,26H,1-2,6,13-15,17,35H2,(H,36,41)(H,37,42)/t26-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187163
((S)-benzyl 1-(5-(4-((3-chlorophenethyl)carbamoyl)b...)Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(Cl)c2)n1 Show InChI InChI=1S/C32H34ClN5O5/c33-26-10-6-9-22(19-26)16-18-35-31(40)25-14-12-23(13-15-25)20-28-37-30(38-43-28)29(39)27(11-4-5-17-34)36-32(41)42-21-24-7-2-1-3-8-24/h1-3,6-10,12-15,19,27H,4-5,11,16-18,20-21,34H2,(H,35,40)(H,36,41)/t27-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187160
(CHEMBL213928 | N-[(2S)-6-amino-1-{5-[(4-{[2-(3-chl...)Show SMILES NCCCC[C@H](NC(=O)c1ccc(F)cc1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(Cl)c2)n1 Show InChI InChI=1S/C31H31ClFN5O4/c32-24-5-3-4-20(18-24)15-17-35-30(40)22-9-7-21(8-10-22)19-27-37-29(38-42-27)28(39)26(6-1-2-16-34)36-31(41)23-11-13-25(33)14-12-23/h3-5,7-14,18,26H,1-2,6,15-17,19,34H2,(H,35,40)(H,36,41)/t26-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187168
(CHEMBL377656 | N-[(2S)-6-amino-1-{5-[(4-{[2-(3-chl...)Show SMILES NCCCC[C@H](NC(=O)c1ccc(Cl)cc1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(Cl)c2)n1 Show InChI InChI=1S/C31H31Cl2N5O4/c32-24-13-11-23(12-14-24)31(41)36-26(6-1-2-16-34)28(39)29-37-27(42-38-29)19-21-7-9-22(10-8-21)30(40)35-17-15-20-4-3-5-25(33)18-20/h3-5,7-14,18,26H,1-2,6,15-17,19,34H2,(H,35,40)(H,36,41)/t26-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187176
((S)-ethyl 1-(5-(4-((3-chlorophenethyl)carbamoyl)be...)Show SMILES CCOC(=O)N[C@@H](CCCCN)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(Cl)c2)n1 Show InChI InChI=1S/C27H32ClN5O5/c1-2-37-27(36)31-22(8-3-4-14-29)24(34)25-32-23(38-33-25)17-19-9-11-20(12-10-19)26(35)30-15-13-18-6-5-7-21(28)16-18/h5-7,9-12,16,22H,2-4,8,13-15,17,29H2,1H3,(H,30,35)(H,31,36)/t22-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187162
((S)-N-(3-chlorophenethyl)-4-((3-(6-amino-2-pivalam...)Show SMILES CC(C)(C)C(=O)N[C@@H](CCCCN)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(Cl)c2)n1 Show InChI InChI=1S/C29H36ClN5O4/c1-29(2,3)28(38)33-23(9-4-5-15-31)25(36)26-34-24(39-35-26)18-20-10-12-21(13-11-20)27(37)32-16-14-19-7-6-8-22(30)17-19/h6-8,10-13,17,23H,4-5,9,14-16,18,31H2,1-3H3,(H,32,37)(H,33,38)/t23-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM50069825
(4-Pyrrolidin-3-yl-1H-imidazole | CHEMBL79983)Show InChI InChI=1S/C7H11N3/c1-2-8-3-6(1)7-4-9-5-10-7/h4-6,8H,1-3H2,(H,9,10) | PDB
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor |
Bioorg Med Chem Lett 8: 243-8 (1999)
BindingDB Entry DOI: 10.7270/Q2ST7P0Z |
More data for this Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50180400
(2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6,2'-...)Show SMILES NC(=O)NCc1ccc(O)c(c1)-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O Show InChI InChI=1S/C26H24N6O7/c27-23(28)12-2-3-18-19(8-12)32-24(31-18)17-7-13(14(25(37)38)9-21(34)35)6-16(22(17)36)15-5-11(1-4-20(15)33)10-30-26(29)39/h1-8,14,33,36H,9-10H2,(H3,27,28)(H,31,32)(H,34,35)(H,37,38)(H3,29,30,39) | PDB
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DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description Binding affinity to F7a/TF complex |
Bioorg Med Chem Lett 16: 2037-41 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.059 BindingDB Entry DOI: 10.7270/Q2639PBP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187182
((S)-N-(1-(5-(4-((3-chlorophenethyl)carbamoyl)benzy...)Show SMILES NCCCC[C@H](NC(=O)c1ccc2OCOc2c1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(Cl)c2)n1 Show InChI InChI=1S/C32H32ClN5O6/c33-24-5-3-4-20(16-24)13-15-35-31(40)22-9-7-21(8-10-22)17-28-37-30(38-44-28)29(39)25(6-1-2-14-34)36-32(41)23-11-12-26-27(18-23)43-19-42-26/h3-5,7-12,16,18,25H,1-2,6,13-15,17,19,34H2,(H,35,40)(H,36,41)/t25-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM50069816
(4-((3R,4R)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)Show InChI InChI=1S/C8H13N3/c1-6-2-9-3-7(6)8-4-10-5-11-8/h4-7,9H,2-3H2,1H3,(H,10,11)/t6-,7-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor |
Bioorg Med Chem Lett 8: 243-8 (1999)
BindingDB Entry DOI: 10.7270/Q2ST7P0Z |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187164
((S)-benzyl 1-(5-(4-((2-(thiophen-2-yl)ethyl)carbam...)Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccs2)n1 Show InChI InChI=1S/C30H33N5O5S/c31-16-5-4-10-25(33-30(38)39-20-22-7-2-1-3-8-22)27(36)28-34-26(40-35-28)19-21-11-13-23(14-12-21)29(37)32-17-15-24-9-6-18-41-24/h1-3,6-9,11-14,18,25H,4-5,10,15-17,19-20,31H2,(H,32,37)(H,33,38)/t25-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM50189938
(2-{5-(4-amino-1H-pyrrolo[3,2-c]pyridin-2-yl)-3'-[3...)Show SMILES CC(C)(C(O)=O)c1cc(-c2cc3c(N)nccc3[nH]2)c(O)c(c1)-c1cccc(CNC(=O)Nc2c(F)cccc2F)c1 Show InChI InChI=1S/C31H27F2N5O4/c1-31(2,29(40)41)18-12-19(27(39)20(13-18)25-14-21-24(37-25)9-10-35-28(21)34)17-6-3-5-16(11-17)15-36-30(42)38-26-22(32)7-4-8-23(26)33/h3-14,37,39H,15H2,1-2H3,(H2,34,35)(H,40,41)(H2,36,38,42) | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description Binding affinity to f7a/TF complex |
Bioorg Med Chem Lett 16: 4567-70 (2006)
Article DOI: 10.1016/j.bmcl.2006.06.016 BindingDB Entry DOI: 10.7270/Q2NG4Q67 |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM14312
(CHEMBL214368 | CRA23 | ethyl N-[(2S)-6-amino-1-(5-...)Show SMILES CCOC(=O)N[C@@H](CCCCN)C(=O)c1noc(Cc2ccc(cc2)C(=O)NC2Cc3ccccc3C2)n1 |r| Show InChI InChI=1S/C28H33N5O5/c1-2-37-28(36)31-23(9-5-6-14-29)25(34)26-32-24(38-33-26)15-18-10-12-19(13-11-18)27(35)30-22-16-20-7-3-4-8-21(20)17-22/h3-4,7-8,10-13,22-23H,2,5-6,9,14-17,29H2,1H3,(H,30,35)(H,31,36)/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Histamine H3 receptor
(GUINEA PIG) | BDBM50034708
(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)Show InChI InChI=1S/C8H13N3/c1-6-7(2-3-10-6)8-4-9-5-11-8/h4-7,10H,2-3H2,1H3,(H,9,11)/t6-,7+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
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Patents
Similars
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| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Binding afinity against Histamine H3 receptor |
J Med Chem 38: 1593-9 (1995)
BindingDB Entry DOI: 10.7270/Q2BK1BC1 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM50034708
(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)Show InChI InChI=1S/C8H13N3/c1-6-7(2-3-10-6)8-4-9-5-11-8/h4-7,10H,2-3H2,1H3,(H,9,11)/t6-,7+/m1/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Patents
Similars
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| 2.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Binding afinity against Histamine H3 receptor |
J Med Chem 38: 1593-9 (1995)
BindingDB Entry DOI: 10.7270/Q2BK1BC1 |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187169
((S)-benzyl 1-(5-(4-((2-(4-fluorophenoxy)ethyl)carb...)Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCOc2ccc(F)cc2)n1 Show InChI InChI=1S/C32H34FN5O6/c33-25-13-15-26(16-14-25)42-19-18-35-31(40)24-11-9-22(10-12-24)20-28-37-30(38-44-28)29(39)27(8-4-5-17-34)36-32(41)43-21-23-6-2-1-3-7-23/h1-3,6-7,9-16,27H,4-5,8,17-21,34H2,(H,35,40)(H,36,41)/t27-/m0/s1 | PDB
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UniProtKB/SwissProt
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Similars
| Article PubMed
| 2.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187179
((S)-benzyl 1-(5-(4-((3-phenylpropyl)carbamoyl)benz...)Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCCc2ccccc2)n1 Show InChI InChI=1S/C33H37N5O5/c34-20-8-7-15-28(36-33(41)42-23-26-12-5-2-6-13-26)30(39)31-37-29(43-38-31)22-25-16-18-27(19-17-25)32(40)35-21-9-14-24-10-3-1-4-11-24/h1-6,10-13,16-19,28H,7-9,14-15,20-23,34H2,(H,35,40)(H,36,41)/t28-/m0/s1 | PDB
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UniProtKB/SwissProt
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| Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM50034708
(4-((2R,3S)-2-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)Show InChI InChI=1S/C8H13N3/c1-6-7(2-3-10-6)8-4-9-5-11-8/h4-7,10H,2-3H2,1H3,(H,9,11)/t6-,7+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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Similars
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| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor |
Bioorg Med Chem Lett 8: 243-8 (1999)
BindingDB Entry DOI: 10.7270/Q2ST7P0Z |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM50069823
(4-((3S,4R)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)Show InChI InChI=1S/C8H13N3/c1-6-2-9-3-7(6)8-4-10-5-11-8/h4-7,9H,2-3H2,1H3,(H,10,11)/t6-,7+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor |
Bioorg Med Chem Lett 8: 243-8 (1999)
BindingDB Entry DOI: 10.7270/Q2ST7P0Z |
More data for this Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM14312
(CHEMBL214368 | CRA23 | ethyl N-[(2S)-6-amino-1-(5-...)Show SMILES CCOC(=O)N[C@@H](CCCCN)C(=O)c1noc(Cc2ccc(cc2)C(=O)NC2Cc3ccccc3C2)n1 |r| Show InChI InChI=1S/C28H33N5O5/c1-2-37-28(36)31-23(9-5-6-14-29)25(34)26-32-24(38-33-26)15-18-10-12-19(13-11-18)27(35)30-22-16-20-7-3-4-8-21(20)17-22/h3-4,7-8,10-13,22-23H,2,5-6,9,14-17,29H2,1H3,(H,30,35)(H,31,36)/t23-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
| Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... |
Biochemistry 45: 5964-73 (2006)
Article DOI: 10.1021/bi060173m BindingDB Entry DOI: 10.7270/Q2W09450 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187154
((S)-benzyl 1-(5-(4-(phenethylcarbamoyl)benzyl)-1,2...)Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2ccccc2)n1 Show InChI InChI=1S/C32H35N5O5/c33-19-8-7-13-27(35-32(40)41-22-25-11-5-2-6-12-25)29(38)30-36-28(42-37-30)21-24-14-16-26(17-15-24)31(39)34-20-18-23-9-3-1-4-10-23/h1-6,9-12,14-17,27H,7-8,13,18-22,33H2,(H,34,39)(H,35,40)/t27-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187157
((S)-benzyl 1-(5-(4-((3,5-difluorophenethyl)carbamo...)Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cc(F)cc(F)c2)n1 Show InChI InChI=1S/C32H33F2N5O5/c33-25-16-23(17-26(34)19-25)13-15-36-31(41)24-11-9-21(10-12-24)18-28-38-30(39-44-28)29(40)27(8-4-5-14-35)37-32(42)43-20-22-6-2-1-3-7-22/h1-3,6-7,9-12,16-17,19,27H,4-5,8,13-15,18,20,35H2,(H,36,41)(H,37,42)/t27-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187165
((S)-benzyl 1-(5-(4-(cinnamylcarbamoyl)benzyl)-1,2,...)Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NC\C=C\c2ccccc2)n1 Show InChI InChI=1S/C33H35N5O5/c34-20-8-7-15-28(36-33(41)42-23-26-12-5-2-6-13-26)30(39)31-37-29(43-38-31)22-25-16-18-27(19-17-25)32(40)35-21-9-14-24-10-3-1-4-11-24/h1-6,9-14,16-19,28H,7-8,15,20-23,34H2,(H,35,40)(H,36,41)/b14-9+/t28-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187158
((S)-benzyl 1-(5-(4-((2,3-dihydro-1H-inden-2-yl)car...)Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NC2Cc3ccccc3C2)n1 Show InChI InChI=1S/C33H35N5O5/c34-17-7-6-12-28(36-33(41)42-21-23-8-2-1-3-9-23)30(39)31-37-29(43-38-31)18-22-13-15-24(16-14-22)32(40)35-27-19-25-10-4-5-11-26(25)20-27/h1-5,8-11,13-16,27-28H,6-7,12,17-21,34H2,(H,35,40)(H,36,41)/t28-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Histamine H1 receptor
(RAT) | BDBM22868
(11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-b...)Show SMILES [#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C20H22N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12H,8-11,13-14H2,1H3 | KEGG
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| 3.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand |
J Med Chem 34: 457-61 (1991)
BindingDB Entry DOI: 10.7270/Q2BV7FK0 |
More data for this Ligand-Target Pair | |
Coagulation factor VII/Tissue factor
(Homo sapiens (Human)) | BDBM14898
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(F)ccc1O)C(CC(O)=O)C(O)=O Show InChI InChI=1S/C24H19FN4O6/c25-12-2-4-19(30)14(8-12)15-5-11(13(24(34)35)9-20(31)32)6-16(21(15)33)23-28-17-3-1-10(22(26)27)7-18(17)29-23/h1-8,13,30,33H,9H2,(H3,26,27)(H,28,29)(H,31,32)(H,34,35) | PDB
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description Binding affinity to F7a/TF complex |
Bioorg Med Chem Lett 16: 2037-41 (2006)
Article DOI: 10.1016/j.bmcl.2005.12.059 BindingDB Entry DOI: 10.7270/Q2639PBP |
More data for this Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM14311
(CRA22 | N-[(2S)-6-amino-1-(5-{[4-(2,3-dihydro-1H-i...)Show SMILES NCCCC[C@H](NC(=O)c1ccc(F)c(F)c1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NC2Cc3ccccc3C2)n1 |r| Show InChI InChI=1S/C32H31F2N5O4/c33-25-13-12-23(18-26(25)34)32(42)37-27(7-3-4-14-35)29(40)30-38-28(43-39-30)15-19-8-10-20(11-9-19)31(41)36-24-16-21-5-1-2-6-22(21)17-24/h1-2,5-6,8-13,18,24,27H,3-4,7,14-17,35H2,(H,36,41)(H,37,42)/t27-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
| Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... |
Biochemistry 45: 5964-73 (2006)
Article DOI: 10.1021/bi060173m BindingDB Entry DOI: 10.7270/Q2W09450 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM50069822
(4-((3S,4S)-4-Methyl-pyrrolidin-3-yl)-1H-imidazole ...)Show InChI InChI=1S/C8H13N3/c1-6-2-9-3-7(6)8-4-10-5-11-8/h4-7,9H,2-3H2,1H3,(H,10,11)/t6-,7-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
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| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor |
Bioorg Med Chem Lett 8: 243-8 (1999)
BindingDB Entry DOI: 10.7270/Q2ST7P0Z |
More data for this Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187800
((S)-ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazo...)Show SMILES CCOC(=O)N[C@@H](CCCCN)C(=O)c1noc(Cc2ccc(OCCc3ccccc3)cc2)n1 Show InChI InChI=1S/C26H32N4O5/c1-2-33-26(32)28-22(10-6-7-16-27)24(31)25-29-23(35-30-25)18-20-11-13-21(14-12-20)34-17-15-19-8-4-3-5-9-19/h3-5,8-9,11-14,22H,2,6-7,10,15-18,27H2,1H3,(H,28,32)/t22-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description Binding affinity to human tryptase beta2 |
Bioorg Med Chem Lett 16: 4085-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.088 BindingDB Entry DOI: 10.7270/Q2X929W7 |
More data for this Ligand-Target Pair | |
Histamine H1 receptor
(RAT) | BDBM35938
(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)Show InChI InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3 | KEGG
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| 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes |
Bioorg Med Chem Lett 8: 3469-74 (1999)
BindingDB Entry DOI: 10.7270/Q21J98X8 |
More data for this Ligand-Target Pair | |
Tryptase
(Rattus norvegicus) | BDBM50187800
((S)-ethyl 1-(5-(4-phenethoxybenzyl)-1,2,4-oxadiazo...)Show SMILES CCOC(=O)N[C@@H](CCCCN)C(=O)c1noc(Cc2ccc(OCCc3ccccc3)cc2)n1 Show InChI InChI=1S/C26H32N4O5/c1-2-33-26(32)28-22(10-6-7-16-27)24(31)25-29-23(35-30-25)18-20-11-13-21(14-12-20)34-17-15-19-8-4-3-5-9-19/h3-5,8-9,11-14,22H,2,6-7,10,15-18,27H2,1H3,(H,28,32)/t22-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera Genomics
Curated by ChEMBL
| Assay Description Binding affinity to rat tryptase |
Bioorg Med Chem Lett 16: 4085-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.04.088 BindingDB Entry DOI: 10.7270/Q2X929W7 |
More data for this Ligand-Target Pair | |
Histamine H1 receptor
(RAT) | BDBM35938
(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)Show InChI InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3 | KEGG
UniProtKB/SwissProt
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| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Corporation
Curated by ChEMBL
| Assay Description Binding affinity to histamine H1 receptor in rat brain membranes was evaluated using [3H]-pyrilamine as radioligand |
J Med Chem 34: 457-61 (1991)
BindingDB Entry DOI: 10.7270/Q2BV7FK0 |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187172
((S)-benzyl 6-amino-1-oxo-1-(5-((4-(4-phenylbutyl)p...)Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1noc(CN2CCN(CCCCc3ccccc3)CC2)n1 Show InChI InChI=1S/C31H42N6O4/c32-17-9-7-16-27(33-31(39)40-24-26-14-5-2-6-15-26)29(38)30-34-28(41-35-30)23-37-21-19-36(20-22-37)18-10-8-13-25-11-3-1-4-12-25/h1-6,11-12,14-15,27H,7-10,13,16-24,32H2,(H,33,39)/t27-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Tryptase beta-2
(Homo sapiens (Human)) | BDBM14316
((2R)-N-[(2S)-1-(5-{[4-(2,3-dihydro-1H-inden-2-ylca...)Show SMILES CC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC1CCNC1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NC2Cc3ccccc3C2)n1 |r| Show InChI InChI=1S/C34H40N6O5/c1-21(41)40-16-4-7-29(40)34(44)37-28(13-10-23-14-15-35-20-23)31(42)32-38-30(45-39-32)17-22-8-11-24(12-9-22)33(43)36-27-18-25-5-2-3-6-26(25)19-27/h2-3,5-6,8-9,11-12,23,27-29,35H,4,7,10,13-20H2,1H3,(H,36,43)(H,37,44)/t23?,28-,29+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
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| Article PubMed
| 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
| Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis... |
Biochemistry 45: 5964-73 (2006)
Article DOI: 10.1021/bi060173m BindingDB Entry DOI: 10.7270/Q2W09450 |
More data for this Ligand-Target Pair | |
Histamine H1 receptor
(RAT) | BDBM50063449
(8-Chloro-11-piperazin-1-yl-6,11-dihydro-5H-benzo[5...)Show InChI InChI=1S/C18H20ClN3/c19-15-5-6-16-14(12-15)4-3-13-2-1-7-21-17(13)18(16)22-10-8-20-9-11-22/h1-2,5-7,12,18,20H,3-4,8-11H2 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
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| PubMed
| 6.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes |
Bioorg Med Chem Lett 8: 3469-74 (1999)
BindingDB Entry DOI: 10.7270/Q21J98X8 |
More data for this Ligand-Target Pair | |
Histamine H1 receptor
(RAT) | BDBM50073184
(8-Chloro-11-(4-methyl-piperazin-1-yl)-6,11-dihydro...)Show InChI InChI=1S/C19H22ClN3/c1-22-9-11-23(12-10-22)19-17-7-6-16(20)13-15(17)5-4-14-3-2-8-21-18(14)19/h2-3,6-8,13,19H,4-5,9-12H2,1H3 | KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| PubMed
| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Binding affinity against Histamine H1 receptor using receptor binding assay in rat brain membranes |
Bioorg Med Chem Lett 8: 3469-74 (1999)
BindingDB Entry DOI: 10.7270/Q21J98X8 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM50069818
(4-((2R,3S)-2-Methyl-azetidin-3-yl)-1H-imidazole | ...)Show InChI InChI=1S/C7H11N3/c1-5-6(2-9-5)7-3-8-4-10-7/h3-6,9H,2H2,1H3,(H,8,10)/t5-,6+/m1/s1 | PDB
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| 7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of [3H]-N-alpha-methylhistamine binding to guinea pig brain Histamine H3 receptor |
Bioorg Med Chem Lett 8: 243-8 (1999)
BindingDB Entry DOI: 10.7270/Q2ST7P0Z |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM50071496
(CHEMBL73053 | N-(4-Chloro-benzyl)-2-[4-(1H-imidazo...)Show InChI InChI=1S/C19H19ClN4/c20-17-7-5-16(6-8-17)11-23-19(21)10-15-3-1-14(2-4-15)9-18-12-22-13-24-18/h1-8,12-13H,9-11H2,(H2,21,23)(H,22,24) | PDB
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| 7.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of N-alpha-methylhistamine binding to histamine H3 receptor of guinea pig brain membranes |
Bioorg Med Chem Lett 8: 2263-8 (1999)
BindingDB Entry DOI: 10.7270/Q2TD9WH3 |
More data for this Ligand-Target Pair | |
Histamine H3 receptor
(GUINEA PIG) | BDBM22914
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20) | PDB
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| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 7.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description Inhibition of N-alpha-methylhistamine binding to histamine H3 receptor of guinea pig brain membranes |
Bioorg Med Chem Lett 8: 2263-8 (1999)
BindingDB Entry DOI: 10.7270/Q2TD9WH3 |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187178
((S)-benzyl 1-(5-(4-((3-(trifluoromethyl)phenethyl)...)Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1noc(Cc2ccc(cc2)C(=O)NCCc2cccc(c2)C(F)(F)F)n1 Show InChI InChI=1S/C33H34F3N5O5/c34-33(35,36)26-10-6-9-22(19-26)16-18-38-31(43)25-14-12-23(13-15-25)20-28-40-30(41-46-28)29(42)27(11-4-5-17-37)39-32(44)45-21-24-7-2-1-3-8-24/h1-3,6-10,12-15,19,27H,4-5,11,16-18,20-21,37H2,(H,38,43)(H,39,44)/t27-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187151
((S)-benzyl 1-(5-(4-(isopentylcarbamoyl)benzyl)-1,2...)Show SMILES CC(C)CCNC(=O)c1ccc(Cc2nc(no2)C(=O)[C@H](CCCCN)NC(=O)OCc2ccccc2)cc1 Show InChI InChI=1S/C29H37N5O5/c1-20(2)15-17-31-28(36)23-13-11-21(12-14-23)18-25-33-27(34-39-25)26(35)24(10-6-7-16-30)32-29(37)38-19-22-8-4-3-5-9-22/h3-5,8-9,11-14,20,24H,6-7,10,15-19,30H2,1-2H3,(H,31,36)(H,32,37)/t24-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 9.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |
Histamine H1 receptor
(RAT) | BDBM50281832
(1-[4-(3-Bromo-8-chloro-5,6-dihydro-benzo[5,6]cyclo...)Show SMILES [#6]-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccc(Cl)cc2-[#6]-[#6]-c2cc(Br)cnc-12 Show InChI InChI=1S/C21H20BrClN2O/c1-13(26)25-8-6-14(7-9-25)20-19-5-4-18(23)11-15(19)2-3-16-10-17(22)12-24-21(16)20/h4-5,10-12H,2-3,6-9H2,1H3 | KEGG
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane. |
Bioorg Med Chem Lett 3: 1073-1078 (1993)
Article DOI: 10.1016/S0960-894X(00)80290-5 BindingDB Entry DOI: 10.7270/Q2445MDZ |
More data for this Ligand-Target Pair | |
Dimer of Tryptase beta-2
(Homo sapiens (Human)) | BDBM50187175
((S)-benzyl 6-amino-1-oxo-1-(5-((4-(3-phenylpropyl)...)Show SMILES NCCCC[C@H](NC(=O)OCc1ccccc1)C(=O)c1noc(CN2CCN(CCCc3ccccc3)CC2)n1 Show InChI InChI=1S/C30H40N6O4/c31-16-8-7-15-26(32-30(38)39-23-25-12-5-2-6-13-25)28(37)29-33-27(40-34-29)22-36-20-18-35(19-21-36)17-9-14-24-10-3-1-4-11-24/h1-6,10-13,26H,7-9,14-23,31H2,(H,32,38)/t26-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Celera
Curated by ChEMBL
| Assay Description Inhibition of human beta tryptase |
Bioorg Med Chem Lett 16: 4036-40 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.009 BindingDB Entry DOI: 10.7270/Q20864ZV |
More data for this Ligand-Target Pair | |