Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM71464 (US9546164, 495 | US9694002, 495) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM71464 (US9546164, 495 | US9694002, 495) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 7.2 | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Mus musculus) | BDBM50169425 (CHEMBL3341983 | US9481677, 44) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of Nav1.7 channel in mouse CAD cells by whole-cell patch clamp assay | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50118514 (CHEMBL3617063 | US9481677, 38) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.2 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71381 (US9546164, 440 | US9694002, 440) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145281 (US8952169, 60 | US9771376, Example 60) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | 37 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145281 (US8952169, 60 | US9771376, Example 60) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ... | US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM275877 (US10071957, Example 96) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Preparation of membranes containing recombinantly expressed sodium channels: Frozen recombinant cell pellets were thawed on ice and diluted to 4 time... | US Patent US10071957 (2018) BindingDB Entry DOI: 10.7270/Q2J1056P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71381 (US9546164, 440 | US9694002, 440) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50118514 (CHEMBL3617063 | US9481677, 38) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at -150 mV by manual voltage c... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50118514 (CHEMBL3617063 | US9481677, 38) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50169425 (CHEMBL3341983 | US9481677, 44) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145285 (US8952169, 64 | US9771376, Example 64) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ... | US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50169425 (CHEMBL3341983 | US9481677, 44) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta3 at -150 mV by manual voltage c... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145285 (US8952169, 64 | US9771376, Example 64) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | 37 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50169426 (CHEMBL3806065 | US9481677, 69) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.7 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -60 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71340 (US9546164, 411 | US9694002, 411) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM50118514 (CHEMBL3617063 | US9481677, 38) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of full length human Nav1.6 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by... | ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71340 (US9546164, 411 | US9694002, 411) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM70845 (US9546164, 6 | US9694002, 27) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | 7.2 | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM70816 (US9546164, 4 | US9694002, 6) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50024248 (CHEMBL3325528) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK cells assessed as reduction in sodium current at -60 mV holding potential by PatchXpress platform based w... | Bioorg Med Chem Lett 24: 4397-401 (2014) Article DOI: 10.1016/j.bmcl.2014.08.017 BindingDB Entry DOI: 10.7270/Q2FF3TX9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145374 (US8952169, 153) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145384 (US8952169, 163) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145412 (US8952169, 191) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145281 (US8952169, 60 | US9771376, Example 60) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145369 (US8952169, 148 | US9771376, Example 148) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM374028 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m... | Citation and Details BindingDB Entry DOI: 10.7270/Q2XS5ZK1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM526220 (4-((2-(azetidin-1-ylmethyl)benzyl)amino)-3-chloro-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and... | Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM526223 (4-((2-(azetidin-1-ylmethyl)benzyl)amino)-2,6-diflu...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which... | Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM526223 (4-((2-(azetidin-1-ylmethyl)benzyl)amino)-2,6-diflu...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and... | Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM374028 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and... | US Patent US10815229 (2020) BindingDB Entry DOI: 10.7270/Q2MS3WTS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM374028 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. US Patent | Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ... | US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM374028 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM268527 (N-(6-cyclopropyl-7-((3,5-dichlorophenoxy)methyl)-[...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inhibition of inactivated state of recombinant human NaV1.7 expressed in HEK293 cell membranes coexpressing Nav beta1 subunit assessed as decrease in... | J Med Chem 61: 4810-4831 (2018) Article DOI: 10.1021/acs.jmedchem.7b01826 BindingDB Entry DOI: 10.7270/Q2BV7K92 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM71211 (US9546164, 312 | US9694002, 312) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.2 | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM47141 (US8952169, 185 | US8952169, 297) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 37 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM71211 (US9546164, 312 | US9694002, 312) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM47139 (US8952169, 175 | US8952169, 295) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | 37 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145371 (US8952169, 150 | US9771376, Example 150) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.4 | 25 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50024246 (CHEMBL3325526 | US9630929, Example 77) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenon Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK cells assessed as reduction in sodium current at -60 mV holding potential by PatchXpress platform based w... | Bioorg Med Chem Lett 24: 4397-401 (2014) Article DOI: 10.1016/j.bmcl.2014.08.017 BindingDB Entry DOI: 10.7270/Q2FF3TX9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71351 (US9546164, 422 | US9694002, 422) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71351 (US9546164, 422 | US9694002, 422) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145307 (US8952169, 86 | US9771376, Example 86) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.31 | n/a | n/a | n/a | n/a | n/a | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ... | US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145307 (US8952169, 86 | US9771376, Example 86) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.31 | n/a | n/a | n/a | n/a | n/a | 37 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145369 (US8952169, 148 | US9771376, Example 148) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | 37 |
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent | Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all... | US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM145369 (US8952169, 148 | US9771376, Example 148) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ... | US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM71341 (US9546164, 412 | US9694002, 412) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer... | US Patent US9546164 (2017) BindingDB Entry DOI: 10.7270/Q2JD4ZS4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71341 (US9546164, 412 | US9694002, 412) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human)) | BDBM71063 (US9546164, 208 | US9694002, 208) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.4 | 25 |
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent | Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc... | US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG | |||||||||||
More data for this Ligand-Target Pair |
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