Compile Data Set for Download or QSAR

Found 4005 hits with Last Name = 'gude' and Initial = 'm'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM257871 (US9493446, 340) Show SMILES COc1c(F)cccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(C)c(C)cc1-n1nccn1 Show InChI InChI=1S/C24H23FN6O3/c1-14-12-17(20(13-15(14)2)31-26-9-10-27-31)24(32)30-11-5-8-19(30)22-28-23(34-29-22)16-6-4-7-18(25)21(16)33-3/h4,6-7,9-10,12-13,19H,5,8,11H2,1-3H3/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Human orexin-A as an agonist is prepared as 1 mM stock solution in MeOH: water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA), NaH...				US Patent US9493446 (2016) BindingDB Entry DOI: 10.7270/Q2DR2TD0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335161 (US11040966, Example 6.121 | US9732075, Example 6.1...) Show SMILES COc1cccc(c1)-c1sc(C)nc1C(=O)N1CC(=C)C[C@H]1c1nc2ccc(Cl)c(C)c2[nH]1 Show InChI InChI=1S/C25H23ClN4O2S/c1-13-10-20(24-28-19-9-8-18(26)14(2)21(19)29-24)30(12-13)25(31)22-23(33-15(3)27-22)16-6-5-7-17(11-16)32-4/h5-9,11,20H,1,10,12H2,2-4H3,(H,28,29)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335172 (US11040966, Example 6.131 | US9732075, Example 6.1...) Show SMILES COc1ccc(c(c1)C(=O)N1CC(=C)C[C@H]1c1nc2ccc(Cl)c(C)c2[nH]1)-n1nccn1 Show InChI InChI=1S/C23H21ClN6O2/c1-13-10-20(22-27-18-6-5-17(24)14(2)21(18)28-22)29(12-13)23(31)16-11-15(32-3)4-7-19(16)30-25-8-9-26-30/h4-9,11,20H,1,10,12H2,2-3H3,(H,27,28)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM257862 (US9493446, 331) Show SMILES CCOc1ncccc1-c1nc(no1)[C@@H]1CCCN1C(=O)c1cc(C)c(C)cc1-n1nccn1 Show InChI InChI=1S/C24H25N7O3/c1-4-33-22-17(7-5-9-25-22)23-28-21(29-34-23)19-8-6-12-30(19)24(32)18-13-15(2)16(3)14-20(18)31-26-10-11-27-31/h5,7,9-11,13-14,19H,4,6,8,12H2,1-3H3/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Human orexin-A as an agonist is prepared as 1 mM stock solution in MeOH: water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA), NaH...				US Patent US9493446 (2016) BindingDB Entry DOI: 10.7270/Q2DR2TD0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335171 (US11040966, Example 6.130 | US9732075, Example 6.1...) Show SMILES Cc1cc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(cc1C)-n1nccn1 Show InChI InChI=1S/C24H23ClN6O/c1-13-9-21(23-28-19-6-5-18(25)16(4)22(19)29-23)30(12-13)24(32)17-10-14(2)15(3)11-20(17)31-26-7-8-27-31/h5-8,10-11,21H,1,9,12H2,2-4H3,(H,28,29)/t21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335160 (US11040966, Example 6.120 | US9732075, Example 6.1...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(s1)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C25H20ClF3N4OS/c1-12-9-19(23-31-18-8-7-17(26)13(2)20(18)32-23)33(11-12)24(34)21-22(35-14(3)30-21)15-5-4-6-16(10-15)25(27,28)29/h4-8,10,19H,1,9,11H2,2-3H3,(H,31,32)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335162 (US11040966, Example 6.122 | US9732075, Example 6.1...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(s1)-c1cccc(C)c1 Show InChI InChI=1S/C25H23ClN4OS/c1-13-6-5-7-17(10-13)23-22(27-16(4)32-23)25(31)30-12-14(2)11-20(30)24-28-19-9-8-18(26)15(3)21(19)29-24/h5-10,20H,2,11-12H2,1,3-4H3,(H,28,29)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335180 ((4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(S)-2...) Show SMILES COc1ccc2nc([nH]c2c1)[C@@H]1CC(=C)CN1C(=O)c1cc(C)c(C)cc1-n1nccn1 Show InChI InChI=1S/C24H24N6O2/c1-14-9-22(23-27-19-6-5-17(32-4)12-20(19)28-23)29(13-14)24(31)18-10-15(2)16(3)11-21(18)30-25-7-8-26-30/h5-8,10-12,22H,1,9,13H2,2-4H3,(H,27,28)/t22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM334712 (US11040966, Example 4.70 | US9732075, Example 4.70...) Show SMILES C[C@H]1CCN([C@@H]1c1nc2c(C)c(Cl)ccc2[nH]1)C(=O)c1nc(C)sc1-c1ccc(F)cc1 Show InChI InChI=1S/C24H22ClFN4OS/c1-12-10-11-30(21(12)23-28-18-9-8-17(25)13(2)19(18)29-23)24(31)20-22(32-14(3)27-20)15-4-6-16(26)7-5-15/h4-9,12,21H,10-11H2,1-3H3,(H,28,29)/t12-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335163 (US11040966, Example 6.123 | US9732075, Example 6.1...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(s1)-c1cccc(Br)c1 Show InChI InChI=1S/C24H20BrClN4OS/c1-12-9-19(23-28-18-8-7-17(26)13(2)20(18)29-23)30(11-12)24(31)21-22(32-14(3)27-21)15-5-4-6-16(25)10-15/h4-8,10,19H,1,9,11H2,2-3H3,(H,28,29)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335151 (US11040966, Example 6.112 | US9732075, Example 6.1...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3cccc(C)c3[nH]2)c(s1)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C25H21F3N4OS/c1-13-10-19(23-30-18-9-4-6-14(2)20(18)31-23)32(12-13)24(33)21-22(34-15(3)29-21)16-7-5-8-17(11-16)25(26,27)28/h4-9,11,19H,1,10,12H2,2-3H3,(H,30,31)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM334620 (US11040966, Example 3.41 | US9732075, Example 3.41...) Show SMILES CO[C@@H]1C[C@H](N(C1)C(=O)c1nc(sc1-c1cccc(Cl)c1)N(C)C)c1nc2ccc(Cl)c(C)c2[nH]1 Show InChI InChI=1S/C25H25Cl2N5O2S/c1-13-17(27)8-9-18-20(13)29-23(28-18)19-11-16(34-4)12-32(19)24(33)21-22(35-25(30-21)31(2)3)14-6-5-7-15(26)10-14/h5-10,16,19H,11-12H2,1-4H3,(H,28,29)/t16-,19+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335153 (US11040966, Example 6.114 | US9732075, Example 6.1...) Show SMILES COc1cccc(c1)-c1sc(C)nc1C(=O)N1CC(=C)C[C@H]1c1nc2cccc(C)c2[nH]1 Show InChI InChI=1S/C25H24N4O2S/c1-14-11-20(24-27-19-10-5-7-15(2)21(19)28-24)29(13-14)25(30)22-23(32-16(3)26-22)17-8-6-9-18(12-17)31-4/h5-10,12,20H,1,11,13H2,2-4H3,(H,27,28)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335165 (US11040966, Example 6.125 | US9732075, Example 6.1...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(s1)-c1ccc(F)c(Br)c1 Show InChI InChI=1S/C24H19BrClFN4OS/c1-11-8-19(23-29-18-7-5-16(26)12(2)20(18)30-23)31(10-11)24(32)21-22(33-13(3)28-21)14-4-6-17(27)15(25)9-14/h4-7,9,19H,1,8,10H2,2-3H3,(H,29,30)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335142 (US11040966, Example 6.104 | US9732075, Example 6.1...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3cccc(C)c3[nH]2)c(s1)-c1cccc(Br)c1 Show InChI InChI=1S/C24H21BrN4OS/c1-13-10-19(23-27-18-9-4-6-14(2)20(18)28-23)29(12-13)24(30)21-22(31-15(3)26-21)16-7-5-8-17(25)11-16/h4-9,11,19H,1,10,12H2,2-3H3,(H,27,28)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335166 (US11040966, Example 6.126 | US9732075, Example 6.1...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(s1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H19Cl3N4OS/c1-11-8-19(23-29-18-7-6-15(25)12(2)20(18)30-23)31(10-11)24(32)21-22(33-13(3)28-21)14-4-5-16(26)17(27)9-14/h4-7,9,19H,1,8,10H2,2-3H3,(H,29,30)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM334704 (US11040966, Example 4.63 | US9732075, Example 4.63...) Show SMILES C[C@H]1CCN([C@@H]1c1nc2c(C)c(Cl)ccc2[nH]1)C(=O)c1nc(C)sc1-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H22Cl2N4OS/c1-12-10-11-30(21(12)23-28-18-9-8-17(26)13(2)19(18)29-23)24(31)20-22(32-14(3)27-20)15-4-6-16(25)7-5-15/h4-9,12,21H,10-11H2,1-3H3,(H,28,29)/t12-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM334611 (US11040966, Example 3.33 | US9732075, Example 3.33...) Show SMILES CO[C@@H]1C[C@H](N(C1)C(=O)c1nc(sc1-c1ccc(C)c(C)c1)N(C)C)c1nc2ccc(Cl)c(C)c2[nH]1 Show InChI InChI=1S/C27H30ClN5O2S/c1-14-7-8-17(11-15(14)2)24-23(31-27(36-24)32(4)5)26(34)33-13-18(35-6)12-21(33)25-29-20-10-9-19(28)16(3)22(20)30-25/h7-11,18,21H,12-13H2,1-6H3,(H,29,30)/t18-,21+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM334708 (US11040966, Example 4.67 | US9732075, Example 4.67...) Show SMILES C[C@H]1CCN([C@@H]1c1nc2c(C)c(Cl)ccc2[nH]1)C(=O)c1nc(C)sc1-c1cc(F)cc(F)c1 Show InChI InChI=1S/C24H21ClF2N4OS/c1-11-6-7-31(21(11)23-29-18-5-4-17(25)12(2)19(18)30-23)24(32)20-22(33-13(3)28-20)14-8-15(26)10-16(27)9-14/h4-5,8-11,21H,6-7H2,1-3H3,(H,29,30)/t11-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM334612 (US11040966, Example 3.34 | US9732075, Example 3.34...) Show SMILES CO[C@@H]1C[C@H](N(C1)C(=O)c1nc(C)sc1-c1ccc(C)c(C)c1)c1nc2ccc(Cl)c(C)c2[nH]1 Show InChI InChI=1S/C26H27ClN4O2S/c1-13-6-7-17(10-14(13)2)24-23(28-16(4)34-24)26(32)31-12-18(33-5)11-21(31)25-29-20-9-8-19(27)15(3)22(20)30-25/h6-10,18,21H,11-12H2,1-5H3,(H,29,30)/t18-,21+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335139 (US11040966, Example 6.101 | US9732075, Example 6.1...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3cccc(C)c3[nH]2)c(s1)-c1cccc(C)c1 Show InChI InChI=1S/C25H24N4OS/c1-14-7-5-9-18(11-14)23-22(26-17(4)31-23)25(30)29-13-15(2)12-20(29)24-27-19-10-6-8-16(3)21(19)28-24/h5-11,20H,2,12-13H2,1,3-4H3,(H,27,28)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM334702 (US11040966, Example 4.61 | US9732075, Example 4.61...) Show SMILES C[C@H]1CCN([C@@H]1c1nc2c(C)c(Cl)ccc2[nH]1)C(=O)c1ccccc1-c1ccc(C)cc1 Show InChI InChI=1S/C27H26ClN3O/c1-16-8-10-19(11-9-16)20-6-4-5-7-21(20)27(32)31-15-14-17(2)25(31)26-29-23-13-12-22(28)18(3)24(23)30-26/h4-13,17,25H,14-15H2,1-3H3,(H,29,30)/t17-,25-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM334610 (US11040966, Example 3.32 | US9732075, Example 3.32...) Show SMILES CO[C@@H]1C[C@H](N(C1)C(=O)c1nc(C)sc1-c1cccc(C)c1)c1nc2ccc(Cl)c(C)c2[nH]1 Show InChI InChI=1S/C25H25ClN4O2S/c1-13-6-5-7-16(10-13)23-22(27-15(3)33-23)25(31)30-12-17(32-4)11-20(30)24-28-19-9-8-18(26)14(2)21(19)29-24/h5-10,17,20H,11-12H2,1-4H3,(H,28,29)/t17-,20+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM335325 (US11040966, Example 6.93 | US9732075, Example 6.93...) Show SMILES Cc1cccc(c1)-c1sc(nc1C(=O)N1CC(=C)CC1c1nc2c(Br)cccc2[nH]1)C1CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM335162 (US11040966, Example 6.122 | US9732075, Example 6.1...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3ccc(Cl)c(C)c3[nH]2)c(s1)-c1cccc(C)c1 Show InChI InChI=1S/C25H23ClN4OS/c1-13-6-5-7-17(10-13)23-22(27-16(4)32-23)25(31)30-12-14(2)11-20(30)24-28-19-9-8-18(26)15(3)21(19)29-24/h5-10,20H,2,11-12H2,1,3-4H3,(H,28,29)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM334707 (US11040966, Example 4.66 | US9732075, Example 4.66...) Show SMILES COc1ccc(c(c1)C(=O)N1CC[C@H](C)[C@H]1c1nc2c(C)c(Cl)ccc2[nH]1)-n1nccn1 Show InChI InChI=1S/C23H23ClN6O2/c1-13-8-11-29(21(13)22-27-18-6-5-17(24)14(2)20(18)28-22)23(31)16-12-15(32-3)4-7-19(16)30-25-9-10-26-30/h4-7,9-10,12-13,21H,8,11H2,1-3H3,(H,27,28)/t13-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM257813 (US9493446, 282) Show SMILES COc1cc(C(=O)N2CCC[C@H]2c2nc(no2)-c2cccc(F)c2OC)c(cc1Cl)-n1nccn1 Show InChI InChI=1S/C23H20ClFN6O4/c1-33-19-11-14(18(12-15(19)24)31-26-8-9-27-31)23(32)30-10-4-7-17(30)22-28-21(29-35-22)13-5-3-6-16(25)20(13)34-2/h3,5-6,8-9,11-12,17H,4,7,10H2,1-2H3/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Human orexin-A as an agonist is prepared as 1 mM stock solution in MeOH: water (1:1), diluted in HBSS containing 0.1% bovine serum albumin (BSA), NaH...				US Patent US9493446 (2016) BindingDB Entry DOI: 10.7270/Q2DR2TD0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335273 (US11040966, Example 6.45 | US9732075, Example 6.45...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3c(C)c(Cl)ccc3[nH]2)c(s1)-c1cccc(Cl)c1 Show InChI InChI=1S/C24H20Cl2N4OS/c1-12-9-19(23-28-18-8-7-17(26)13(2)20(18)29-23)30(11-12)24(31)21-22(32-14(3)27-21)15-5-4-6-16(25)10-15/h4-8,10,19H,1,9,11H2,2-3H3,(H,28,29)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM334656 (US11040966, Example 4.21 | US9732075, Example 4.21...) Show SMILES C[C@H]1CCN([C@@H]1c1nc2c(C)c(Cl)ccc2[nH]1)C(=O)c1nc(C)sc1-c1cccc(Cl)c1 Show InChI InChI=1S/C24H22Cl2N4OS/c1-12-9-10-30(21(12)23-28-18-8-7-17(26)13(2)19(18)29-23)24(31)20-22(32-14(3)27-20)15-5-4-6-16(25)11-15/h4-8,11-12,21H,9-10H2,1-3H3,(H,28,29)/t12-,21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM334640 (US11040966, Example 3.9 | US9732075, Example 3.9 |...) Show SMILES CO[C@@H]1C[C@H](N(C1)C(=O)c1nc(C)sc1-c1cccc(Cl)c1)c1nc2c(C)c(Cl)ccc2[nH]1 Show InChI InChI=1S/C24H22Cl2N4O2S/c1-12-17(26)7-8-18-20(12)29-23(28-18)19-10-16(32-3)11-30(19)24(31)21-22(33-13(2)27-21)14-5-4-6-15(25)9-14/h4-9,16,19H,10-11H2,1-3H3,(H,28,29)/t16-,19+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM335359 (US11040966, Example 7.23 | US9732075, Example 7.23...) Show SMILES COc1ccc(c(c1)C(=O)N1CCC[C@@]1(C)c1nc2c(C)c(Cl)ccc2n1C)-n1nccn1 Show InChI InChI=1S/C24H25ClN6O2/c1-15-18(25)7-9-20-21(15)28-23(29(20)3)24(2)10-5-13-30(24)22(32)17-14-16(33-4)6-8-19(17)31-26-11-12-27-31/h6-9,11-12,14H,5,10,13H2,1-4H3/t24-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM335369 (US11040966, Example 7.33 | US9732075, Example 7.33...) Show SMILES Cc1nc(C(=O)N2CCC[C@@]2(C)c2nc3c(C)c(Cl)ccc3n2C)c(s1)-c1cccc(Cl)c1 Show InChI InChI=1S/C25H24Cl2N4OS/c1-14-18(27)9-10-19-20(14)29-24(30(19)4)25(3)11-6-12-31(25)23(32)21-22(33-15(2)28-21)16-7-5-8-17(26)13-16/h5,7-10,13H,6,11-12H2,1-4H3/t25-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM334588 (US11040966, Example 3.12 | US9732075, Example 3.12...) Show SMILES CO[C@@H]1C[C@H](N(C1)C(=O)c1cc(OC)ccc1-n1nccn1)c1nc2ccc(Cl)c(C)c2[nH]1 Show InChI InChI=1S/C23H23ClN6O3/c1-13-17(24)5-6-18-21(13)28-22(27-18)20-11-15(33-3)12-29(20)23(31)16-10-14(32-2)4-7-19(16)30-25-8-9-26-30/h4-10,15,20H,11-12H2,1-3H3,(H,27,28)/t15-,20+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM335339 (US11040966, Example 7.3 | US9732075, Example 7.3 |...) Show SMILES Cc1ccc(c(c1)C(=O)N1CCC[C@@]1(C)c1nc2c(C)c(Cl)ccc2n1C)-n1nccn1 Show InChI InChI=1S/C24H25ClN6O/c1-15-6-8-19(31-26-11-12-27-31)17(14-15)22(32)30-13-5-10-24(30,3)23-28-21-16(2)18(25)7-9-20(21)29(23)4/h6-9,11-12,14H,5,10,13H2,1-4H3/t24-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM335354 (US11040966, Example 7.18 | US9732075, Example 7.18...) Show SMILES Cc1ccc(c(n1)C(=O)N1CCC[C@@]1(C)c1nc2c(C)c(Cl)ccc2n1C)-n1nccn1 Show InChI InChI=1S/C23H24ClN7O/c1-14-6-8-18(31-25-11-12-26-31)20(27-14)21(32)30-13-5-10-23(30,3)22-28-19-15(2)16(24)7-9-17(19)29(22)4/h6-9,11-12H,5,10,13H2,1-4H3/t23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM335357 (US11040966, Example 7.21 | US9732075, Example 7.21...) Show SMILES CCn1c(nc2c(C)c(Cl)ccc12)[C@]1(C)CCCN1C(=O)c1cc(C)ccc1-n1nccn1 Show InChI InChI=1S/C25H27ClN6O/c1-5-30-21-10-8-19(26)17(3)22(21)29-24(30)25(4)11-6-14-31(25)23(33)18-15-16(2)7-9-20(18)32-27-12-13-28-32/h7-10,12-13,15H,5-6,11,14H2,1-4H3/t25-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM335358 (US11040966, Example 7.22 | US9732075, Example 7.22...) Show SMILES Cc1c(Cl)ccc2n(C)c(nc12)[C@]1(C)CCCN1C(=O)c1cc(Cl)ccc1-n1nccn1 Show InChI InChI=1S/C23H22Cl2N6O/c1-14-17(25)6-8-19-20(14)28-22(29(19)3)23(2)9-4-12-30(23)21(32)16-13-15(24)5-7-18(16)31-26-10-11-27-31/h5-8,10-11,13H,4,9,12H2,1-3H3/t23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM335318 (US11040966, Example 6.87 | US9732075, Example 6.87...) Show SMILES CSc1cccc2nc([nH]c12)C1CC(=C)CN1C(=O)c1nc(sc1-c1cccc(C)c1)C1CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335322 (US11040966, Example 6.90 | US9732075, Example 6.90...) Show SMILES Cc1cccc(c1)-c1sc(nc1C(=O)N1CC(=C)CC1c1nc2cc(C)c(C)cc2[nH]1)C1CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335323 (US11040966, Example 6.91 | US9732075, Example 6.91...) Show SMILES Cc1cccc(c1)-c1sc(nc1C(=O)N1CC(=C)CC1c1nc2c(C)cc(C)cc2[nH]1)C1CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335326 (US11040966, Example 6.94 | US9732075, Example 6.94...) Show SMILES Cc1cccc(c1)-c1sc(nc1C(=O)N1CC(=C)CC1c1nc2c(C)cccc2[nH]1)C1CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335331 (US11040966, Example 6.99 | US9732075, Example 6.99...) Show SMILES Cc1cccc(c1)-c1sc(nc1C(=O)N1CC(=C)CC1c1nc2cccc(Cl)c2[nH]1)C1CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335282 (US11040966, Example 6.53 | US9732075, Example 6.53...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3c(C)cccc3[nH]2)c(s1)-c1ccc(C)c(C)c1 Show InChI InChI=1S/C26H26N4OS/c1-14-11-21(25-28-20-8-6-7-16(3)22(20)29-25)30(13-14)26(31)23-24(32-18(5)27-23)19-10-9-15(2)17(4)12-19/h6-10,12,21H,1,11,13H2,2-5H3,(H,28,29)/t21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335283 (US11040966, Example 6.54 | US9732075, Example 6.54...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3c(C)c(Cl)ccc3[nH]2)c(s1)-c1ccc(C)c(C)c1 Show InChI InChI=1S/C26H25ClN4OS/c1-13-10-21(25-29-20-9-8-19(27)16(4)22(20)30-25)31(12-13)26(32)23-24(33-17(5)28-23)18-7-6-14(2)15(3)11-18/h6-9,11,21H,1,10,12H2,2-5H3,(H,29,30)/t21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335284 (US11040966, Example 6.55 | US9732075, Example 6.55...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3cc(Cl)c(C)cc3[nH]2)c(s1)-c1ccc(C)c(C)c1 Show InChI InChI=1S/C26H25ClN4OS/c1-13-8-22(25-29-20-10-16(4)19(27)11-21(20)30-25)31(12-13)26(32)23-24(33-17(5)28-23)18-7-6-14(2)15(3)9-18/h6-7,9-11,22H,1,8,12H2,2-5H3,(H,29,30)/t22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335285 (US11040966, Example 6.56 | US9732075, Example 6.56...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3cc(C)c(C)cc3[nH]2)c(s1)-c1ccc(C)c(C)c1 Show InChI InChI=1S/C27H28N4OS/c1-14-9-23(26-29-21-11-17(4)18(5)12-22(21)30-26)31(13-14)27(32)24-25(33-19(6)28-24)20-8-7-15(2)16(3)10-20/h7-8,10-12,23H,1,9,13H2,2-6H3,(H,29,30)/t23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335287 (US11040966, Example 6.58 | US9732075, Example 6.58...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3c(C)cc(C)cc3[nH]2)c(s1)-c1ccc(C)c(C)c1 Show InChI InChI=1S/C27H28N4OS/c1-14-9-18(5)23-21(10-14)29-26(30-23)22-11-15(2)13-31(22)27(32)24-25(33-19(6)28-24)20-8-7-16(3)17(4)12-20/h7-10,12,22H,2,11,13H2,1,3-6H3,(H,29,30)/t22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM335273 (US11040966, Example 6.45 | US9732075, Example 6.45...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3c(C)c(Cl)ccc3[nH]2)c(s1)-c1cccc(Cl)c1 Show InChI InChI=1S/C24H20Cl2N4OS/c1-12-9-19(23-28-18-8-7-17(26)13(2)20(18)29-23)30(11-12)24(31)21-22(32-14(3)27-21)15-5-4-6-16(25)10-15/h4-8,10,19H,1,9,11H2,2-3H3,(H,28,29)/t19-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335275 (US11040966, Example 6.47 | US9732075, Example 6.47...) Show SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3c(C)c(C)ccc3[nH]2)c(s1)-c1ccc(C)c(C)c1 Show InChI InChI=1S/C27H28N4OS/c1-14-11-22(26-29-21-10-8-16(3)18(5)23(21)30-26)31(13-14)27(32)24-25(33-19(6)28-24)20-9-7-15(2)17(4)12-20/h7-10,12,22H,1,11,13H2,2-6H3,(H,29,30)/t22-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM335277 (US11040966, Example 6.49 | US9732075, Example 6.49...) Show SMILES CSc1cccc2[nH]c(nc12)[C@@H]1CC(=C)CN1C(=O)c1nc(C)sc1-c1ccc(C)c(C)c1 Show InChI InChI=1S/C26H26N4OS2/c1-14-11-20(25-28-19-7-6-8-21(32-5)22(19)29-25)30(13-14)26(31)23-24(33-17(4)27-23)18-10-9-15(2)16(3)12-18/h6-10,12,20H,1,11,13H2,2-5H3,(H,28,29)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
IDORSIA PHARMACEUTICALS LTD US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9732075 (2017) BindingDB Entry DOI: 10.7270/Q29P33S0
					More data for this Ligand-Target Pair

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