Found 8 hits with Last Name = 'hasbun-manning' and Initial = 'm' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50243844
(1-(3-Chloro-phenyl)-3-[1-(3,3-dimethyl-butyl)-4-ph...)Show SMILES CC(C)(C)CCN1CCC(CNC(=O)Nc2cccc(Cl)c2)(CC1)c1ccccc1 Show InChI InChI=1S/C25H34ClN3O/c1-24(2,3)12-15-29-16-13-25(14-17-29,20-8-5-4-6-9-20)19-27-23(30)28-22-11-7-10-21(26)18-22/h4-11,18H,12-17,19H2,1-3H3,(H2,27,28,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human ERG by voltage-clamp electrophysiology assay |
J Med Chem 51: 3692-5 (2008)
Article DOI: 10.1021/jm800419w
BindingDB Entry DOI: 10.7270/Q25Q4VXC |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50243845
(3,5-Dichloro-N-[1-(4-methyl-benzyl)-piperidin-4-yl...)Show SMILES Cc1ccc(CN2CCC(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)cc1 Show InChI InChI=1S/C21H24Cl2N2O/c1-15-2-4-17(5-3-15)14-25-8-6-16(7-9-25)13-24-21(26)18-10-19(22)12-20(23)11-18/h2-5,10-12,16H,6-9,13-14H2,1H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human ERG by voltage-clamp electrophysiology assay |
J Med Chem 51: 3692-5 (2008)
Article DOI: 10.1021/jm800419w
BindingDB Entry DOI: 10.7270/Q25Q4VXC |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50243846
(3,5-Dichloro-N-[1-(3,3-dimethyl-butyl)-piperidin-4...)Show SMILES CC(C)(C)CCN1CCC(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 Show InChI InChI=1S/C19H28Cl2N2O/c1-19(2,3)6-9-23-7-4-14(5-8-23)13-22-18(24)15-10-16(20)12-17(21)11-15/h10-12,14H,4-9,13H2,1-3H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.93E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human ERG by voltage-clamp electrophysiology assay |
J Med Chem 51: 3692-5 (2008)
Article DOI: 10.1021/jm800419w
BindingDB Entry DOI: 10.7270/Q25Q4VXC |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50243802
(3,5-Dichloro-N-[1-(3,3-dimethyl-butyl)-4-fluoro-pi...)Show SMILES CC(C)(C)CCN1CCC(F)(CNC(=O)c2cc(Cl)cc(Cl)c2)CC1 Show InChI InChI=1S/C19H27Cl2FN2O/c1-18(2,3)4-7-24-8-5-19(22,6-9-24)13-23-17(25)14-10-15(20)12-16(21)11-14/h10-12H,4-9,13H2,1-3H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human ERG by voltage-clamp electrophysiology assay |
J Med Chem 51: 3692-5 (2008)
Article DOI: 10.1021/jm800419w
BindingDB Entry DOI: 10.7270/Q25Q4VXC |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50243805
((S)-3,5-Dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyr...)Show SMILES CC1(C)C[C@@H](CN2CCC(F)(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)CCO1 |r| Show InChI InChI=1S/C21H29Cl2FN2O2/c1-20(2)12-15(3-8-28-20)13-26-6-4-21(24,5-7-26)14-25-19(27)16-9-17(22)11-18(23)10-16/h9-11,15H,3-8,12-14H2,1-2H3,(H,25,27)/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human ERG by voltage-clamp electrophysiology assay |
J Med Chem 51: 3692-5 (2008)
Article DOI: 10.1021/jm800419w
BindingDB Entry DOI: 10.7270/Q25Q4VXC |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50243804
((R)-3,5-Dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyr...)Show SMILES CC1(C)C[C@H](CN2CCC(F)(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)CCO1 |r| Show InChI InChI=1S/C21H29Cl2FN2O2/c1-20(2)12-15(3-8-28-20)13-26-6-4-21(24,5-7-26)14-25-19(27)16-9-17(22)11-18(23)10-16/h9-11,15H,3-8,12-14H2,1-2H3,(H,25,27)/t15-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human ERG by voltage-clamp electrophysiology assay |
J Med Chem 51: 3692-5 (2008)
Article DOI: 10.1021/jm800419w
BindingDB Entry DOI: 10.7270/Q25Q4VXC |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50243803
(CHEMBL529445 | rac-3,5-Dichloro-N-[1-(2,2-dimethyl...)Show SMILES CC1(C)CC(CN2CCC(F)(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)CCO1 Show InChI InChI=1S/C21H29Cl2FN2O2/c1-20(2)12-15(3-8-28-20)13-26-6-4-21(24,5-7-26)14-25-19(27)16-9-17(22)11-18(23)10-16/h9-11,15H,3-8,12-14H2,1-2H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human ERG by voltage-clamp electrophysiology assay |
J Med Chem 51: 3692-5 (2008)
Article DOI: 10.1021/jm800419w
BindingDB Entry DOI: 10.7270/Q25Q4VXC |
More data for this
Ligand-Target Pair | |
Sodium channel protein type 5 subunit alpha
(Homo sapiens (Human)) | BDBM50243805
((S)-3,5-Dichloro-N-[1-(2,2-dimethyl-tetrahydro-pyr...)Show SMILES CC1(C)C[C@@H](CN2CCC(F)(CNC(=O)c3cc(Cl)cc(Cl)c3)CC2)CCO1 |r| Show InChI InChI=1S/C21H29Cl2FN2O2/c1-20(2)12-15(3-8-28-20)13-26-6-4-21(24,5-7-26)14-25-19(27)16-9-17(22)11-18(23)10-16/h9-11,15H,3-8,12-14H2,1-2H3,(H,25,27)/t15-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of sodium channel Nav1.5 (unknown origin) by voltage-clamp method |
J Med Chem 51: 3692-5 (2008)
Article DOI: 10.1021/jm800419w
BindingDB Entry DOI: 10.7270/Q25Q4VXC |
More data for this
Ligand-Target Pair | |
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