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Compile Data Set for Download or QSAR

Found 152 hits with Last Name = 'hechenberger' and Initial = 'm'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50084137
PNG
(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Show SMILES Cc1cccc(n1)C#Cc1ccccc1
Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
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 12n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50084137
PNG
(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)
Show SMILES Cc1cccc(n1)C#Cc1ccccc1
Show InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
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 12n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231755
PNG
(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Show SMILES CC1(C)CCc2nc(ccc2C1=O)C#Cc1ccccc1
Show InChI InChI=1S/C19H17NO/c1-19(2)13-12-17-16(18(19)21)11-10-15(20-17)9-8-14-6-4-3-5-7-14/h3-7,10-11H,12-13H2,1-2H3
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 51n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231728
PNG
(5-methoxy-2-phenylethynyl-5,6,7,8-tetrahydro-quino...)
Show SMILES COC1CCCc2nc(ccc12)C#Cc1ccccc1 |w:2.1|
Show InChI InChI=1S/C18H17NO/c1-20-18-9-5-8-17-16(18)13-12-15(19-17)11-10-14-6-3-2-4-7-14/h2-4,6-7,12-13,18H,5,8-9H2,1H3
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 139n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231738
PNG
(7,7-dimethyl-2-pyridin-2-ylethynyl-7,8-dihydro-6H-...)
Show SMILES CC1(C)CC(=O)c2ccc(nc2C1)C#Cc1ccccn1
Show InChI InChI=1S/C18H16N2O/c1-18(2)11-16-15(17(21)12-18)9-8-14(20-16)7-6-13-5-3-4-10-19-13/h3-5,8-10H,11-12H2,1-2H3
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 210n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231741
PNG
(2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...)
Show SMILES O=C1CCCc2nc(ccc12)C#Cc1ccccc1
Show InChI InChI=1S/C17H13NO/c19-17-8-4-7-16-15(17)12-11-14(18-16)10-9-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-8H2
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 800n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231751
PNG
(6-phenylethynyl-nicotinic acid methyl ester | CHEM...)
Show SMILES COC(=O)c1ccc(nc1)C#Cc1ccccc1
Show InChI InChI=1S/C15H11NO2/c1-18-15(17)13-8-10-14(16-11-13)9-7-12-5-3-2-4-6-12/h2-6,8,10-11H,1H3
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 1.40E+3n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231753
PNG
(2-phenylethynyl-5,6,7,8-tetrahydro-quinoline | CHE...)
Show SMILES C1CCc2nc(ccc2C1)C#Cc1ccccc1
Show InChI InChI=1S/C17H15N/c1-2-6-14(7-3-1)10-12-16-13-11-15-8-4-5-9-17(15)18-16/h1-3,6-7,11,13H,4-5,8-9H2
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 1.50E+3n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231721
PNG
(2-pyridin-2-ylethynyl-7,8-dihydro-6H-quinolin-5-on...)
Show SMILES O=C1CCCc2nc(ccc12)C#Cc1ccccn1
Show InChI InChI=1S/C16H12N2O/c19-16-6-3-5-15-14(16)10-9-13(18-15)8-7-12-4-1-2-11-17-12/h1-2,4,9-11H,3,5-6H2
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 2.36E+3n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231747
PNG
((R)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Show SMILES O[C@@H]1CCCc2nc(ccc12)C#Cc1ccccc1
Show InChI InChI=1S/C17H15NO/c19-17-8-4-7-16-15(17)12-11-14(18-16)10-9-13-5-2-1-3-6-13/h1-3,5-6,11-12,17,19H,4,7-8H2/t17-/m1/s1
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 4.71E+3n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231719
PNG
(2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-ol |...)
Show SMILES OC1CCCc2nc(ccc12)C#Cc1ccccc1 |w:1.0|
Show InChI InChI=1S/C17H15NO/c19-17-8-4-7-16-15(17)12-11-14(18-16)10-9-13-5-2-1-3-6-13/h1-3,5-6,11-12,17,19H,4,7-8H2
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 7.60E+3n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231759
PNG
((S)-2-phenylethynyl-5,6,7,8-tetrahydro-quinolin-5-...)
Show SMILES O[C@H]1CCCc2nc(ccc12)C#Cc1ccccc1
Show InChI InChI=1S/C17H15NO/c19-17-8-4-7-16-15(17)12-11-14(18-16)10-9-13-5-2-1-3-6-13/h1-3,5-6,11-12,17,19H,4,7-8H2/t17-/m0/s1
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 9.28E+3n/an/an/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50231750
PNG
((3-ethyl-2-methylquinolin-6-yl)(4-methoxycyclohexy...)
Show SMILES CCc1cc2cc(ccc2nc1C)C(=O)C1CCC(CC1)OC |(-9.6,3.19,;-8.27,3.96,;-6.93,3.19,;-5.6,3.96,;-4.27,3.2,;-2.94,3.97,;-1.61,3.21,;-1.6,1.66,;-2.93,.89,;-4.27,1.65,;-5.6,.87,;-6.93,1.64,;-8.27,.88,;-.28,3.99,;-.29,5.53,;1.06,3.22,;1.06,1.68,;2.39,.92,;3.73,1.69,;3.72,3.23,;2.38,4,;5.06,.92,;5.07,-.62,)|
Show InChI InChI=1S/C20H25NO2/c1-4-14-11-17-12-16(7-10-19(17)21-13(14)2)20(22)15-5-8-18(23-3)9-6-15/h7,10-12,15,18H,4-6,8-9H2,1-3H3
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n/an/a 3n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphate

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50231744
PNG
(CHEMBL399160 | NPS 2390 | quinoxaline-2-carboxylic...)
Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)c1cnc2ccccc2n1 |TLB:2:3:6:10.8.9,THB:8:7:4:10.9.11,8:9:6.7.12:4,11:9:6:12.3.4,11:3:6:10.8.9|
Show InChI InChI=1S/C19H21N3O/c23-18(17-11-20-15-3-1-2-4-16(15)21-17)22-19-8-12-5-13(9-19)7-14(6-12)10-19/h1-4,11-14H,5-10H2,(H,22,23)
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n/an/a 5n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphate

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50231749
PNG
(6-ethyl-5-methyl-3-(1,2,4,5-tetrahydrobenzo[d]azep...)
Show SMILES CCc1nc(C#N)c(nc1C)N1CCc2ccccc2CC1
Show InChI InChI=1S/C18H20N4/c1-3-16-13(2)20-18(17(12-19)21-16)22-10-8-14-6-4-5-7-15(14)9-11-22/h4-7H,3,8-11H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphate

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50231755
PNG
(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Show SMILES CC1(C)CCc2nc(ccc2C1=O)C#Cc1ccccc1
Show InChI InChI=1S/C19H17NO/c1-19(2)13-12-17-16(18(19)21)11-10-15(20-17)9-8-14-6-4-3-5-7-14/h3-7,10-11H,12-13H2,1-2H3
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n/an/a 23n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231755
PNG
(6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinol...)
Show SMILES CC1(C)CCc2nc(ccc2C1=O)C#Cc1ccccc1
Show InChI InChI=1S/C19H17NO/c1-19(2)13-12-17-16(18(19)21)11-10-15(20-17)9-8-14-6-4-3-5-7-14/h3-7,10-11H,12-13H2,1-2H3
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n/an/a 23n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443088
PNG
(CHEMBL3087216)
Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(Cl)c1 |r,TLB:2:4:9.10.12:6.7|
Show InChI InChI=1S/C17H18ClNO3/c1-22-16(20)19-14-5-6-15(19)11-17(21,10-14)8-7-12-3-2-4-13(18)9-12/h2-4,9,14-15,21H,5-6,10-11H2,1H3/t14-,15+,17+
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n/an/a 27n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438277
PNG
(CHEMBL2408412)
Show SMILES CC1CC(=O)c2cc(cnc2C1)C#Cc1ccccc1
Show InChI InChI=1S/C18H15NO/c1-13-9-17-16(18(20)10-13)11-15(12-19-17)8-7-14-5-3-2-4-6-14/h2-6,11-13H,9-10H2,1H3
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n/an/a 28n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443089
PNG
(CHEMBL3086715)
Show SMILES COC(=O)N1CCC(O)(C#Cc2cccc(C)c2)[C@@H]2CCC[C@H]12 |r|
Show InChI InChI=1S/C19H23NO3/c1-14-5-3-6-15(13-14)9-10-19(22)11-12-20(18(21)23-2)17-8-4-7-16(17)19/h3,5-6,13,16-17,22H,4,7-8,11-12H2,1-2H3/t16-,17+,19?/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443089
PNG
(CHEMBL3086715)
Show SMILES COC(=O)N1CCC(O)(C#Cc2cccc(C)c2)[C@@H]2CCC[C@H]12 |r|
Show InChI InChI=1S/C19H23NO3/c1-14-5-3-6-15(13-14)9-10-19(22)11-12-20(18(21)23-2)17-8-4-7-16(17)19/h3,5-6,13,16-17,22H,4,7-8,11-12H2,1-2H3/t16-,17+,19?/m1/s1
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n/an/a 28.4n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438295
PNG
(CHEMBL2408568)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(Cl)cc3)nc2C1
Show InChI InChI=1S/C15H14ClN3O/c1-9-6-13-12(14(20)7-9)8-17-15(19-13)18-11-4-2-10(16)3-5-11/h2-5,8-9H,6-7H2,1H3,(H,17,18,19)
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n/an/a 34n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443090
PNG
(CHEMBL3086712)
Show SMILES COC(=O)N1CCC2CC(O)(C#Cc3cccc(C)c3)C2C1
Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)6-8-18(21)11-15-7-9-19(12-16(15)18)17(20)22-2/h3-5,10,15-16,21H,7,9,11-12H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438289
PNG
(CHEMBL2408574)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(Cl)nc3)nc2C1
Show InChI InChI=1S/C14H13ClN4O/c1-8-4-11-10(12(20)5-8)7-17-14(19-11)18-9-2-3-13(15)16-6-9/h2-3,6-8H,4-5H2,1H3,(H,17,18,19)
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n/an/a 43n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443091
PNG
(CHEMBL3087511)
Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(C)c1 |r,THB:2:4:10.12.9:7.6|
Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)8-9-18(21)11-15-6-7-16(12-18)19(15)17(20)22-2/h3-5,10,15-16,21H,6-7,11-12H2,1-2H3/t15-,16+,18+
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n/an/a 47n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443092
PNG
(CHEMBL3085792)
Show SMILES CCOC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(C)c1 |r,TLB:3:5:10.11.13:7.8|
Show InChI InChI=1S/C19H23NO3/c1-3-23-18(21)20-16-7-8-17(20)13-19(22,12-16)10-9-15-6-4-5-14(2)11-15/h4-6,11,16-17,22H,3,7-8,12-13H2,1-2H3/t16-,17+,19+
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n/an/a 48n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443093
PNG
(CHEMBL3087217)
Show SMILES COC(=O)N1[C@@H]2CC[C@@H]1CC(O)(C2)C#Cc1cccc(C)c1 |r,TLB:2:4:6.7:12.10.9,13:10:4:6.7,THB:11:10:4:6.7|
Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)8-9-18(21)11-15-6-7-16(12-18)19(15)17(20)22-2/h3-5,10,15-16,21H,6-7,11-12H2,1-2H3/t15-,16-/m1/s1
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n/an/a 51n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50231748
PNG
(CHEMBL253347 | quinoline-3-carboxylic acid adamant...)
Show SMILES O=C(NC12CC3CC(CC(C3)C1)C2)c1cnc2ccccc2c1 |TLB:2:3:6:10.8.9,THB:8:7:4:10.9.11,8:9:6.7.12:4,11:9:6:12.3.4,11:3:6:10.8.9|
Show InChI InChI=1S/C20H22N2O/c23-19(17-8-16-3-1-2-4-18(16)21-12-17)22-20-9-13-5-14(10-20)7-15(6-13)11-20/h1-4,8,12-15H,5-7,9-11H2,(H,22,23)
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n/an/a 52n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphate

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443087
PNG
(CHEMBL3087214)
Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(F)c1 |r,TLB:2:4:9.10.12:6.7|
Show InChI InChI=1S/C17H18FNO3/c1-22-16(20)19-14-5-6-15(19)11-17(21,10-14)8-7-12-3-2-4-13(18)9-12/h2-4,9,14-15,21H,5-6,10-11H2,1H3/t14-,15+,17+
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n/an/a 61n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443086
PNG
(CHEMBL3087508)
Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@H](C2)C#Cc1cccc(C)c1 |r,TLB:2:4:9.10.11:6.7|
Show InChI InChI=1S/C18H21NO2/c1-13-4-3-5-14(10-13)6-7-15-11-16-8-9-17(12-15)19(16)18(20)21-2/h3-5,10,15-17H,8-9,11-12H2,1-2H3/t15-,16-,17+
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n/an/a 65n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438278
PNG
(CHEMBL2408411)
Show SMILES CC1(C)CC(=O)c2cc(cnc2C1)C#Cc1ccccc1
Show InChI InChI=1S/C19H17NO/c1-19(2)11-17-16(18(21)12-19)10-15(13-20-17)9-8-14-6-4-3-5-7-14/h3-7,10,13H,11-12H2,1-2H3
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n/an/a 68n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443084
PNG
(CHEMBL3087220)
Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(OC(F)F)c1 |r,TLB:2:4:9.10.12:6.7|
Show InChI InChI=1S/C18H19F2NO4/c1-24-17(22)21-13-5-6-14(21)11-18(23,10-13)8-7-12-3-2-4-15(9-12)25-16(19)20/h2-4,9,13-14,16,23H,5-6,10-11H2,1H3/t13-,14+,18+
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n/an/a 72n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443085
PNG
(AFQ056 | Mavoglurant)
Show SMILES COC(=O)N1CC[C@@H]2[C@H]1CCC[C@@]2(O)C#Cc1cccc(C)c1 |r|
Show InChI InChI=1S/C19H23NO3/c1-14-5-3-6-15(13-14)8-11-19(22)10-4-7-17-16(19)9-12-20(17)18(21)23-2/h3,5-6,13,16-17,22H,4,7,9-10,12H2,1-2H3/t16-,17-,19-/m1/s1
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n/an/a 72n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443083
PNG
(CHEMBL3087219)
Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(OC)c1 |r,TLB:2:4:9.10.12:6.7|
Show InChI InChI=1S/C18H21NO4/c1-22-16-5-3-4-13(10-16)8-9-18(21)11-14-6-7-15(12-18)19(14)17(20)23-2/h3-5,10,14-15,21H,6-7,11-12H2,1-2H3/t14-,15+,18+
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n/an/a 76n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50231758
PNG
(2-cyclopentylamino-7,7-dimethyl-5-oxo-5,6,7,8-tetr...)
Show SMILES CC1(C)CC(=O)c2cc(C#N)c(NC3CCCC3)nc2C1
Show InChI InChI=1S/C17H21N3O/c1-17(2)8-14-13(15(21)9-17)7-11(10-18)16(20-14)19-12-5-3-4-6-12/h7,12H,3-6,8-9H2,1-2H3,(H,19,20)
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n/an/a 78n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphate

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50231728
PNG
(5-methoxy-2-phenylethynyl-5,6,7,8-tetrahydro-quino...)
Show SMILES COC1CCCc2nc(ccc12)C#Cc1ccccc1 |w:2.1|
Show InChI InChI=1S/C18H17NO/c1-20-18-9-5-8-17-16(18)13-12-15(19-17)11-10-14-6-3-2-4-7-14/h2-4,6-7,12-13,18H,5,8-9H2,1H3
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n/an/a 80n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Displacement of [3H]MPEP from rat mGluR5

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438294
PNG
(CHEMBL2408569)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(cc3)C#N)nc2C1
Show InChI InChI=1S/C16H14N4O/c1-10-6-14-13(15(21)7-10)9-18-16(20-14)19-12-4-2-11(8-17)3-5-12/h2-5,9-10H,6-7H2,1H3,(H,18,19,20)
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n/an/a 83n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443082
PNG
(CHEMBL3087513)
Show SMILES COC(=O)N1C[C@@H]2CC[C@H]1C[C@@]2(O)C#Cc1cccc(C)c1 |r,TLB:2:4:11.10:7.8|
Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)8-9-18(21)11-16-7-6-15(18)12-19(16)17(20)22-2/h3-5,10,15-16,21H,6-7,11-12H2,1-2H3/t15-,16-,18-/m0/s1
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n/an/a 85n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438298
PNG
(CHEMBL2408565)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C)cc3)nc2C1
Show InChI InChI=1S/C16H17N3O/c1-10-3-5-12(6-4-10)18-16-17-9-13-14(19-16)7-11(2)8-15(13)20/h3-6,9,11H,7-8H2,1-2H3,(H,17,18,19)
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Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443081
PNG
(CHEMBL3087212)
Show SMILES COC(=O)N1CCCCC11CCCC(O)(C1)C#Cc1cccc(C)c1
Show InChI InChI=1S/C21H27NO3/c1-17-7-5-8-18(15-17)9-13-21(24)12-6-11-20(16-21)10-3-4-14-22(20)19(23)25-2/h5,7-8,15,24H,3-4,6,10-12,14,16H2,1-2H3
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n/an/a 86n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443080
PNG
(CHEMBL3087514)
Show SMILES COC(=O)N1C[C@@H]2CCC(O)(C#Cc3cccc(C)c3)[C@@H]2C1 |r|
Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)6-8-18(21)9-7-15-11-19(12-16(15)18)17(20)22-2/h3-5,10,15-16,21H,7,9,11-12H2,1-2H3/t15-,16+,18?/m0/s1
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n/an/a 103n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443080
PNG
(CHEMBL3087514)
Show SMILES COC(=O)N1C[C@@H]2CCC(O)(C#Cc3cccc(C)c3)[C@@H]2C1 |r|
Show InChI InChI=1S/C18H21NO3/c1-13-4-3-5-14(10-13)6-8-18(21)9-7-15-11-19(12-16(15)18)17(20)22-2/h3-5,10,15-16,21H,7,9,11-12H2,1-2H3/t15-,16+,18?/m0/s1
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n/an/a 103n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50231757
PNG
(2-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl...)
Show SMILES CC1(C)CC(=O)c2cc(C#N)c(nc2C1)N1CCC(=CC1)c1ccc(F)cc1 |c:20|
Show InChI InChI=1S/C23H22FN3O/c1-23(2)12-20-19(21(28)13-23)11-17(14-25)22(26-20)27-9-7-16(8-10-27)15-3-5-18(24)6-4-15/h3-7,11H,8-10,12-13H2,1-2H3
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n/an/a 110n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphate

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438288
PNG
(CHEMBL2408575)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C)nc3)nc2C1
Show InChI InChI=1S/C15H16N4O/c1-9-5-13-12(14(20)6-9)8-17-15(19-13)18-11-4-3-10(2)16-7-11/h3-4,7-9H,5-6H2,1-2H3,(H,17,18,19)
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n/an/a 111n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438305
PNG
(CHEMBL2408585)
Show SMILES Clc1cccc(Nc2ncc3C(=O)CCCc3n2)c1
Show InChI InChI=1S/C14H12ClN3O/c15-9-3-1-4-10(7-9)17-14-16-8-11-12(18-14)5-2-6-13(11)19/h1,3-4,7-8H,2,5-6H2,(H,16,17,18)
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n/an/a 120n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438291
PNG
(CHEMBL2408572)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(OC(F)F)cc3)nc2C1
Show InChI InChI=1S/C16H15F2N3O2/c1-9-6-13-12(14(22)7-9)8-19-16(21-13)20-10-2-4-11(5-3-10)23-15(17)18/h2-5,8-9,15H,6-7H2,1H3,(H,19,20,21)
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n/an/a 125n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 1


(RAT)		BDBM50231743
PNG
(7,7-dimethyl-5-oxo-2-(4-phenyl-piperazin-1-yl)-5,6...)
Show SMILES CC1(C)CC(=O)c2cc(C#N)c(nc2C1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C22H24N4O/c1-22(2)13-19-18(20(27)14-22)12-16(15-23)21(24-19)26-10-8-25(9-11-26)17-6-4-3-5-7-17/h3-7,12H,8-11,13-14H2,1-2H3
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n/an/a 130n/an/an/an/an/an/a



Institute of Organic Synthesis

Curated by ChEMBL


Assay Description
Antagonist activity at rat mGluR1 expressed in cerebellar granule cells assessed as accumulation of [3H]inositol phosphate

J Med Chem 51: 634-47 (2008)


Article DOI: 10.1021/jm0611298
BindingDB Entry DOI: 10.7270/Q2QC04B2
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443079
PNG
(CHEMBL3087225)
Show SMILES CN(C)C(=O)N1[C@H]2CC[C@@H]1C[C@](O)(C2)C#Cc1cccc(C)c1 |r,TLB:3:5:10.11.13:7.8|
Show InChI InChI=1S/C19H24N2O2/c1-14-5-4-6-15(11-14)9-10-19(23)12-16-7-8-17(13-19)21(16)18(22)20(2)3/h4-6,11,16-17,23H,7-8,12-13H2,1-3H3/t16-,17+,19+
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n/an/a 132n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50443078
PNG
(CHEMBL3087509)
Show SMILES COC(=O)N1[C@H]2CC[C@@H]1C[C@@](C2)(OC)C#Cc1cccc(C)c1 |r,TLB:2:4:9.10.11:6.7|
Show InChI InChI=1S/C19H23NO3/c1-14-5-4-6-15(11-14)9-10-19(23-3)12-16-7-8-17(13-19)20(16)18(21)22-2/h4-6,11,16-17H,7-8,12-13H2,1-3H3/t16-,17+,19+
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n/an/a 137n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGlu5 receptor expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular calcium m...

Bioorg Med Chem Lett 23: 6370-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.09.059
BindingDB Entry DOI: 10.7270/Q2W37XRD
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50438293
PNG
(CHEMBL2408570)
Show SMILES CC1CC(=O)c2cnc(Nc3ccc(C#N)c(F)c3)nc2C1
Show InChI InChI=1S/C16H13FN4O/c1-9-4-14-12(15(22)5-9)8-19-16(21-14)20-11-3-2-10(7-18)13(17)6-11/h2-3,6,8-9H,4-5H2,1H3,(H,19,20,21)
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n/an/a 157n/an/an/an/an/an/a



Merz Pharmaceuticals GmbH

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO cells assessed as inhibition of L-quisqualate-induced intracellular cAMP accumulation...

Bioorg Med Chem Lett 23: 4493-500 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.049
BindingDB Entry DOI: 10.7270/Q2KD20B8
More data for this
Ligand-Target Pair
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