Compile Data Set for Download or QSAR

Found 371 hits with Last Name = 'husten' and Initial = 'j'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361211 (CHEMBL1934340) Show SMILES CN(c1cccc(c1)-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12)S(C)(=O)=O Show InChI InChI=1S/C27H31N7O3S/c1-32(38(2,36)37)23-5-3-4-21(16-23)25-11-10-24-17-29-27(31-34(24)25)30-22-8-6-19(7-9-22)20-12-14-33(15-13-20)18-26(28)35/h3-11,16-17,20H,12-15,18H2,1-2H3,(H2,28,35)(H,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50353049 (CHEMBL1822511) Show SMILES COc1cc(Nc2ncc3ccc(-c4ccccc4)n3n2)cc(OC)c1OC Show InChI InChI=1S/C21H20N4O3/c1-26-18-11-15(12-19(27-2)20(18)28-3)23-21-22-13-16-9-10-17(25(16)24-21)14-7-5-4-6-8-14/h4-13H,1-3H3,(H,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361210 (CHEMBL1934339) Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12 Show InChI InChI=1S/C26H29N7O3S/c1-37(35,36)31-22-4-2-3-20(15-22)24-10-9-23-16-28-26(30-33(23)24)29-21-7-5-18(6-8-21)19-11-13-32(14-12-19)17-25(27)34/h2-10,15-16,19,31H,11-14,17H2,1H3,(H2,27,34)(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361213 (CHEMBL1934342) Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12 Show InChI InChI=1S/C26H28N6O3S/c1-36(34,35)23-9-4-20(5-10-23)24-11-8-22-16-28-26(30-32(22)24)29-21-6-2-18(3-7-21)19-12-14-31(15-13-19)17-25(27)33/h2-11,16,19H,12-15,17H2,1H3,(H2,27,33)(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361212 (CHEMBL1934341) Show SMILES NC(=O)CN1CCC(CC1)c1ccc(Nc2ncc3ccc(-c4cccc(CO)c4)n3n2)cc1 Show InChI InChI=1S/C26H28N6O2/c27-25(34)16-31-12-10-20(11-13-31)19-4-6-22(7-5-19)29-26-28-15-23-8-9-24(32(23)30-26)21-3-1-2-18(14-21)17-33/h1-9,14-15,20,33H,10-13,16-17H2,(H2,27,34)(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361214 (CHEMBL1934343) Show SMILES CS(=O)(=O)c1cccc(c1)-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12 Show InChI InChI=1S/C26H28N6O3S/c1-36(34,35)23-4-2-3-20(15-23)24-10-9-22-16-28-26(30-32(22)24)29-21-7-5-18(6-8-21)19-11-13-31(14-12-19)17-25(27)33/h2-10,15-16,19H,11-14,17H2,1H3,(H2,27,33)(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361206 (CHEMBL1934335) Show SMILES COc1ccccc1-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12 Show InChI InChI=1S/C26H28N6O2/c1-34-24-5-3-2-4-22(24)23-11-10-21-16-28-26(30-32(21)23)29-20-8-6-18(7-9-20)19-12-14-31(15-13-19)17-25(27)33/h2-11,16,19H,12-15,17H2,1H3,(H2,27,33)(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361208 (CHEMBL1934337) Show SMILES CC(C)(C)NS(=O)(=O)c1cccc(c1)-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12 Show InChI InChI=1S/C29H35N7O3S/c1-29(2,3)34-40(38,39)25-6-4-5-22(17-25)26-12-11-24-18-31-28(33-36(24)26)32-23-9-7-20(8-10-23)21-13-15-35(16-14-21)19-27(30)37/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H2,30,37)(H,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361209 (CHEMBL1934338) Show SMILES COc1ccc(cn1)-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12 Show InChI InChI=1S/C25H27N7O2/c1-34-24-9-4-19(14-27-24)22-8-7-21-15-28-25(30-32(21)22)29-20-5-2-17(3-6-20)18-10-12-31(13-11-18)16-23(26)33/h2-9,14-15,18H,10-13,16H2,1H3,(H2,26,33)(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.770	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360943 (CHEMBL1935274) Show SMILES OC(=O)[C@@H]1CCCN1C(=O)CCC(=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 |r| Show InChI InChI=1S/C26H23N3O6/c30-18(8-9-19(31)29-10-2-5-17(29)26(34)35)12-6-7-16-15(11-12)20-22-21(24(32)28-25(22)33)13-3-1-4-14(13)23(20)27-16/h6-7,11,17,27H,1-5,8-10H2,(H,34,35)(H,28,32,33)/t17-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361207 (CHEMBL1934336) Show SMILES CN(c1ccccc1-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12)S(C)(=O)=O Show InChI InChI=1S/C27H31N7O3S/c1-32(38(2,36)37)24-6-4-3-5-23(24)25-12-11-22-17-29-27(31-34(22)25)30-21-9-7-19(8-10-21)20-13-15-33(16-14-20)18-26(28)35/h3-12,17,20H,13-16,18H2,1-2H3,(H2,28,35)(H,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361215 (CHEMBL1934344) Show SMILES CN(c1ncccc1-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12)S(C)(=O)=O Show InChI InChI=1S/C26H30N8O3S/c1-32(38(2,36)37)25-22(4-3-13-28-25)23-10-9-21-16-29-26(31-34(21)23)30-20-7-5-18(6-8-20)19-11-14-33(15-12-19)17-24(27)35/h3-10,13,16,19H,11-12,14-15,17H2,1-2H3,(H2,27,35)(H,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361204 (CHEMBL1934353) Show SMILES CN(c1ccccc1-c1cc(Cl)c2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12)S(C)(=O)=O Show InChI InChI=1S/C27H30ClN7O3S/c1-33(39(2,37)38)23-6-4-3-5-21(23)24-15-22(28)25-16-30-27(32-35(24)25)31-20-9-7-18(8-10-20)19-11-13-34(14-12-19)17-26(29)36/h3-10,15-16,19H,11-14,17H2,1-2H3,(H2,29,36)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM50361204 (CHEMBL1934353) Show SMILES CN(c1ccccc1-c1cc(Cl)c2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12)S(C)(=O)=O Show InChI InChI=1S/C27H30ClN7O3S/c1-33(39(2,37)38)23-6-4-3-5-21(23)24-15-22(28)25-16-30-27(32-35(24)25)31-20-9-7-18(8-10-20)19-11-13-34(14-12-19)17-26(29)36/h3-10,15-16,19H,11-14,17H2,1-2H3,(H2,29,36)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of JAK3				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360931 (CHEMBL1935262) Show SMILES OC(=O)CCC(=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 Show InChI InChI=1S/C21H16N2O5/c24-14(6-7-15(25)26)9-4-5-13-12(8-9)16-18-17(20(27)23-21(18)28)10-2-1-3-11(10)19(16)22-13/h4-5,8,22H,1-3,6-7H2,(H,25,26)(H,23,27,28)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361223 (CHEMBL1934352) Show SMILES CN(c1ccccc1-c1cc(C)c2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12)S(C)(=O)=O Show InChI InChI=1S/C28H33N7O3S/c1-19-16-25(23-6-4-5-7-24(23)33(2)39(3,37)38)35-26(19)17-30-28(32-35)31-22-10-8-20(9-11-22)21-12-14-34(15-13-21)18-27(29)36/h4-11,16-17,21H,12-15,18H2,1-3H3,(H2,29,36)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50334080 (2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...) Show SMILES CN1c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(N)=O)n3)cc2CCCC1=O Show InChI InChI=1S/C22H21ClN6O2/c1-29-18-10-9-14(11-13(18)5-4-8-19(29)30)26-22-25-12-16(23)21(28-22)27-17-7-3-2-6-15(17)20(24)31/h2-3,6-7,9-12H,4-5,8H2,1H3,(H2,24,31)(H2,25,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of IR kinase				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50361204 (CHEMBL1934353) Show SMILES CN(c1ccccc1-c1cc(Cl)c2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12)S(C)(=O)=O Show InChI InChI=1S/C27H30ClN7O3S/c1-33(39(2,37)38)23-6-4-3-5-21(23)24-15-22(28)25-16-30-27(32-35(24)25)31-20-9-7-18(8-10-20)19-11-13-34(14-12-19)17-26(29)36/h3-10,15-16,19H,11-14,17H2,1-2H3,(H2,29,36)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant FAK expressed in baculovirus expression system after 30 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50361208 (CHEMBL1934337) Show SMILES CC(C)(C)NS(=O)(=O)c1cccc(c1)-c1ccc2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12 Show InChI InChI=1S/C29H35N7O3S/c1-29(2,3)34-40(38,39)25-6-4-5-22(17-25)26-12-11-24-18-31-28(33-36(24)26)32-23-9-7-20(8-10-23)21-13-15-35(16-14-21)19-27(30)37/h4-12,17-18,21,34H,13-16,19H2,1-3H3,(H2,30,37)(H,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant FAK expressed in baculovirus expression system after 30 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334081 (2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...) Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl Show InChI InChI=1S/C23H23ClN6O2/c1-25-22(32)16-7-3-4-8-18(16)28-21-17(24)13-26-23(29-21)27-15-10-11-19-14(12-15)6-5-9-20(31)30(19)2/h3-4,7-8,10-13H,5-6,9H2,1-2H3,(H,25,32)(H2,26,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of c-Met				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361222 (CHEMBL1934351) Show SMILES NC(=O)CN1CCC(CC1)c1ccc(Nc2ncc3ccc(-c4cccc5cccnc45)n3n2)cc1 Show InChI InChI=1S/C28H27N7O/c29-26(36)18-34-15-12-20(13-16-34)19-6-8-22(9-7-19)32-28-31-17-23-10-11-25(35(23)33-28)24-5-1-3-21-4-2-14-30-27(21)24/h1-11,14,17,20H,12-13,15-16,18H2,(H2,29,36)(H,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334080 (2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...) Show SMILES CN1c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(N)=O)n3)cc2CCCC1=O Show InChI InChI=1S/C22H21ClN6O2/c1-29-18-10-9-14(11-13(18)5-4-8-19(29)30)26-22-25-12-16(23)21(28-22)27-17-7-3-2-6-15(17)20(24)31/h2-3,6-7,9-12H,4-5,8H2,1H3,(H2,24,31)(H2,25,26,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of c-Met				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50361566 (CHEMBL1939493) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)OC)c2)ncc1Cl |r| Show InChI InChI=1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)/t19-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360942 (CHEMBL1935273) Show SMILES CC(C)(C)OC(=O)[C@@H]1CCCN1C(=O)CCC(=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 |r| Show InChI InChI=1S/C30H31N3O6/c1-30(2,3)39-29(38)20-8-5-13-33(20)22(35)12-11-21(34)15-9-10-19-18(14-15)23-25-24(27(36)32-28(25)37)16-6-4-7-17(16)26(23)31-19/h9-10,14,20,31H,4-8,11-13H2,1-3H3,(H,32,36,37)/t20-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360930 (CHEMBL1935261) Show SMILES OC(=O)[C@@H]1CCCN1CC(=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 |r| Show InChI InChI=1S/C24H21N3O5/c28-17(10-27-8-2-5-16(27)24(31)32)11-6-7-15-14(9-11)18-20-19(22(29)26-23(20)30)12-3-1-4-13(12)21(18)25-15/h6-7,9,16,25H,1-5,8,10H2,(H,31,32)(H,26,29,30)/t16-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50334082 (2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...) Show SMILES CN1c2ccc(Nc3ncc(Cl)c(Nc4ccccc4C(=O)NCC#C)n3)cc2CCCC1=O Show InChI InChI=1S/C25H23ClN6O2/c1-3-13-27-24(34)18-8-4-5-9-20(18)30-23-19(26)15-28-25(31-23)29-17-11-12-21-16(14-17)7-6-10-22(33)32(21)2/h1,4-5,8-9,11-12,14-15H,6-7,10,13H2,2H3,(H,27,34)(H2,28,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of IR kinase				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50333561 (2-{5-Chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahy...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCN(CCOC)CCc3c2)ncc1Cl Show InChI InChI=1S/C25H28ClFN6O2/c1-28-24(34)19-4-3-5-21(27)22(19)31-23-20(26)15-29-25(32-23)30-18-7-6-16-8-10-33(12-13-35-2)11-9-17(16)14-18/h3-7,14-15H,8-13H2,1-2H3,(H,28,34)(H2,29,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met cytoplasmic domain expressed in baculovirus after 30 mins by time-resolved fluorescence assay				Bioorg Med Chem Lett 21: 660-3 (2011) Article DOI: 10.1016/j.bmcl.2010.12.013 BindingDB Entry DOI: 10.7270/Q2RB74WV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360927 (CHEMBL1935258) Show SMILES CN(CC(O)=O)CC(=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 Show InChI InChI=1S/C22H19N3O5/c1-25(9-16(27)28)8-15(26)10-5-6-14-13(7-10)17-19-18(21(29)24-22(19)30)11-3-2-4-12(11)20(17)23-14/h5-7,23H,2-4,8-9H2,1H3,(H,27,28)(H,24,29,30)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361218 (CHEMBL1934347) Show SMILES NC(=O)CN1CCC(CC1)c1ccc(Nc2ncc3ccc(-c4cnccn4)n3n2)cc1 Show InChI InChI=1S/C23H24N8O/c24-22(32)15-30-11-7-17(8-12-30)16-1-3-18(4-2-16)28-23-27-13-19-5-6-21(31(19)29-23)20-14-25-9-10-26-20/h1-6,9-10,13-14,17H,7-8,11-12,15H2,(H2,24,32)(H,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.90	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant JAK2 expressed in baculovirus expression system after 20 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360941 (CHEMBL1935272) Show SMILES OCCNC(=O)CCC(=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 Show InChI InChI=1S/C23H21N3O5/c27-9-8-24-17(29)7-6-16(28)11-4-5-15-14(10-11)18-20-19(22(30)26-23(20)31)12-2-1-3-13(12)21(18)25-15/h4-5,10,25,27H,1-3,6-9H2,(H,24,29)(H,26,30,31)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334081 (2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...) Show SMILES CNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl Show InChI InChI=1S/C23H23ClN6O2/c1-25-22(32)16-7-3-4-8-18(16)28-21-17(24)13-26-23(29-21)27-15-10-11-19-14(12-15)6-5-9-20(31)30(19)2/h3-4,7-8,10-13H,5-6,9H2,1-2H3,(H,25,32)(H2,26,27,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of human c-Met in human GTL16 cells by cell-based assay				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334083 (2-{5-Chloro-2-[1-(2-methoxy-ethyl)-2-oxo-2,3,4,5-t...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3CCCC(=O)N(CCOC)c3c2)ncc1Cl Show InChI InChI=1S/C25H26ClFN6O3/c1-28-24(35)17-6-4-7-19(27)22(17)31-23-18(26)14-29-25(32-23)30-16-10-9-15-5-3-8-21(34)33(11-12-36-2)20(15)13-16/h4,6-7,9-10,13-14H,3,5,8,11-12H2,1-2H3,(H,28,35)(H2,29,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of c-Met				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334084 (2-[5-Chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahyd...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)CCC3(C)C)c2)ncc1Cl Show InChI InChI=1S/C24H24ClFN6O2/c1-24(2)10-9-19(33)30-18-11-13(7-8-15(18)24)29-23-28-12-16(25)21(32-23)31-20-14(22(34)27-3)5-4-6-17(20)26/h4-8,11-12H,9-10H2,1-3H3,(H,27,34)(H,30,33)(H2,28,29,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of human c-Met in human GTL16 cells by cell-based assay				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334085 (2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...) Show SMILES CCN1c2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc2C(C)(C)CCC1=O Show InChI InChI=1S/C26H28ClFN6O2/c1-5-34-20-13-15(9-10-17(20)26(2,3)12-11-21(34)35)31-25-30-14-18(27)23(33-25)32-22-16(24(36)29-4)7-6-8-19(22)28/h6-10,13-14H,5,11-12H2,1-4H3,(H,29,36)(H2,30,31,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence a...				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360934 (CHEMBL1935265) Show SMILES O=C(CCC(=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1)N1CCCCC1 Show InChI InChI=1S/C26H25N3O4/c30-19(9-10-20(31)29-11-2-1-3-12-29)14-7-8-18-17(13-14)21-23-22(25(32)28-26(23)33)15-5-4-6-16(15)24(21)27-18/h7-8,13,27H,1-6,9-12H2,(H,28,32,33)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360937 (CHEMBL1935268) Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)C(=O)CCC(=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 Show InChI InChI=1S/C30H32N4O6/c1-30(2,3)40-29(39)34-13-11-33(12-14-34)22(36)10-9-21(35)16-7-8-20-19(15-16)23-25-24(27(37)32-28(25)38)17-5-4-6-18(17)26(23)31-20/h7-8,15,31H,4-6,9-14H2,1-3H3,(H,32,37,38)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334084 (2-[5-Chloro-2-(5,5-dimethyl-2-oxo-2,3,4,5-tetrahyd...) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)CCC3(C)C)c2)ncc1Cl Show InChI InChI=1S/C24H24ClFN6O2/c1-24(2)10-9-19(33)30-18-11-13(7-8-15(18)24)29-23-28-12-16(25)21(32-23)31-20-14(22(34)27-3)5-4-6-17(20)26/h4-8,11-12H,9-10H2,1-3H3,(H,27,34)(H,30,33)(H2,28,29,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50334085 (2-[5-Chloro-2-(1-ethyl-5,5-dimethyl-2-oxo-2,3,4,5-...) Show SMILES CCN1c2cc(Nc3ncc(Cl)c(Nc4c(F)cccc4C(=O)NC)n3)ccc2C(C)(C)CCC1=O Show InChI InChI=1S/C26H28ClFN6O2/c1-5-34-20-13-15(9-10-17(20)26(2,3)12-11-21(34)35)31-25-30-14-18(27)23(33-25)32-22-16(24(36)29-4)7-6-8-19(22)28/h6-10,13-14H,5,11-12H2,1-4H3,(H,29,36)(H2,30,31,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of c-Met				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair
Insulin receptor (Homo sapiens (Human))	BDBM50334086 (2-[5-Chloro-2-(1-methyl-2-oxo-2,3,4,5-tetrahydro-1...) Show SMILES CCCNC(=O)c1ccccc1Nc1nc(Nc2ccc3N(C)C(=O)CCCc3c2)ncc1Cl Show InChI InChI=1S/C25H27ClN6O2/c1-3-13-27-24(34)18-8-4-5-9-20(18)30-23-19(26)15-28-25(31-23)29-17-11-12-21-16(14-17)7-6-10-22(33)32(21)2/h4-5,8-9,11-12,14-15H,3,6-7,10,13H2,1-2H3,(H,27,34)(H2,28,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc Curated by ChEMBL					Assay Description Inhibition of IR kinase				Bioorg Med Chem Lett 21: 164-7 (2010) Checked by Author Article DOI: 10.1016/j.bmcl.2010.11.045 BindingDB Entry DOI: 10.7270/Q28W3F85
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50361570 (CHEMBL1939481) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(CC3(C)C)NC(=O)CN(C)C)c2)ncc1Cl Show InChI InChI=1S/C28H32ClFN8O3/c1-28(2)12-21(34-22(39)14-38(4)5)26(41)35-20-11-15(9-10-17(20)28)33-27-32-13-18(29)24(37-27)36-23-16(25(40)31-3)7-6-8-19(23)30/h6-11,13,21H,12,14H2,1-5H3,(H,31,40)(H,34,39)(H,35,41)(H2,32,33,36,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50361223 (CHEMBL1934352) Show SMILES CN(c1ccccc1-c1cc(C)c2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12)S(C)(=O)=O Show InChI InChI=1S/C28H33N7O3S/c1-19-16-25(23-6-4-5-7-24(23)33(2)39(3,37)38)35-26(19)17-30-28(32-35)31-22-10-8-20(9-11-22)21-12-14-34(15-13-21)18-27(29)36/h4-11,16-17,21H,12-15,18H2,1-3H3,(H2,29,36)(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant FAK expressed in baculovirus expression system after 30 mins by time resolved fluorescence assay				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50361560 (CHEMBL1939486) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@@H](CC3(C)C)NC(=O)C(F)(F)F)c2)ncc1Cl |r| Show InChI InChI=1S/C26H24ClF4N7O3/c1-25(2)10-18(36-23(41)26(29,30)31)22(40)35-17-9-12(7-8-14(17)25)34-24-33-11-15(27)20(38-24)37-19-13(21(39)32-3)5-4-6-16(19)28/h4-9,11,18H,10H2,1-3H3,(H,32,39)(H,35,40)(H,36,41)(H2,33,34,37,38)/t18-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360928 (CHEMBL1935259) Show SMILES COC(=O)[C@@H]1CCCN1CC(=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 |r| Show InChI InChI=1S/C25H23N3O5/c1-33-25(32)17-6-3-9-28(17)11-18(29)12-7-8-16-15(10-12)19-21-20(23(30)27-24(21)31)13-4-2-5-14(13)22(19)26-16/h7-8,10,17,26H,2-6,9,11H2,1H3,(H,27,30,31)/t17-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360929 (CHEMBL1935260) Show SMILES CC(C)(C)OC(=O)[C@@H]1CCCN1CC(=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 |r| Show InChI InChI=1S/C28H29N3O5/c1-28(2,3)36-27(35)19-8-5-11-31(19)13-20(32)14-9-10-18-17(12-14)21-23-22(25(33)30-26(23)34)15-6-4-7-16(15)24(21)29-18/h9-10,12,19,29H,4-8,11,13H2,1-3H3,(H,30,33,34)/t19-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50361569 (CHEMBL1939321) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)C(N)CC3(C)C)c2)ncc1Cl Show InChI InChI=1S/C24H25ClFN7O2/c1-24(2)10-17(27)22(35)31-18-9-12(7-8-14(18)24)30-23-29-11-15(25)20(33-23)32-19-13(21(34)28-3)5-4-6-16(19)26/h4-9,11,17H,10,27H2,1-3H3,(H,28,34)(H,31,35)(H2,29,30,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360946 (CHEMBL1935277) Show SMILES CN1N=C(CCC1=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 |c:2| Show InChI InChI=1S/C22H18N4O3/c1-26-16(27)8-7-14(25-26)10-5-6-15-13(9-10)17-19-18(21(28)24-22(19)29)11-3-2-4-12(11)20(17)23-15/h5-6,9,23H,2-4,7-8H2,1H3,(H,24,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50361204 (CHEMBL1934353) Show SMILES CN(c1ccccc1-c1cc(Cl)c2cnc(Nc3ccc(cc3)C3CCN(CC(N)=O)CC3)nn12)S(C)(=O)=O Show InChI InChI=1S/C27H30ClN7O3S/c1-33(39(2,37)38)23-6-4-3-5-21(23)24-15-22(28)25-16-30-27(32-35(24)25)31-20-9-7-18(8-10-20)19-11-13-34(14-12-19)17-26(29)36/h3-10,15-16,19H,11-14,17H2,1-2H3,(H2,29,36)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of JAK2 in GM-CSF-stimulated human TF1 cells preincubated for 1 hr prior to challenge				Bioorg Med Chem Lett 22: 133-7 (2011) Article DOI: 10.1016/j.bmcl.2011.11.049 BindingDB Entry DOI: 10.7270/Q2C829R4
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50361567 (CHEMBL1939494) Show SMILES CNC(=O)c1cccc(F)c1Nc1nc(Nc2ccc3c(NC(=O)[C@H](CC3(C)C)NC(=O)OC)c2)ncc1Cl |r| Show InChI InChI=1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)/t19-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay				Bioorg Med Chem 19: 6274-84 (2011) Article DOI: 10.1016/j.bmc.2011.09.006 BindingDB Entry DOI: 10.7270/Q24M950J
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360932 (CHEMBL1935263) Show SMILES CCN(CC)C(=O)CCC(=O)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 Show InChI InChI=1S/C25H25N3O4/c1-3-28(4-2)19(30)11-10-18(29)13-8-9-17-16(12-13)20-22-21(24(31)27-25(22)32)14-6-5-7-15(14)23(20)26-17/h8-9,12,26H,3-7,10-11H2,1-2H3,(H,27,31,32)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM50360923 (CHEMBL1935254) Show SMILES O=C(CN1CCOCC1)c1ccc2[nH]c3c4CCCc4c4C(=O)NC(=O)c4c3c2c1 Show InChI InChI=1S/C23H21N3O4/c27-17(11-26-6-8-30-9-7-26)12-4-5-16-15(10-12)18-20-19(22(28)25-23(20)29)13-2-1-3-14(13)21(18)24-16/h4-5,10,24H,1-3,6-9,11H2,(H,25,28,29)	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Cephalon, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant human PARP1 by in vitro assay				Bioorg Med Chem Lett 22: 222-4 (2011) Article DOI: 10.1016/j.bmcl.2011.11.032 BindingDB Entry DOI: 10.7270/Q2X92BQD
					More data for this Ligand-Target Pair

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