Compile Data Set for Download or QSAR

Found 94 hits with Last Name = 'johansson' and Initial = 'ke'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365480 (CHEMBL1957366) Show SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C22H12F3N3O2/c23-22(24,25)30-19-4-2-1-3-15(19)13-5-7-14(8-6-13)20-16(11-26)21(29)17-12-27-10-9-18(17)28-20/h1-10,12H,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365495 (CHEMBL1957460) Show SMILES Cc1nccc(-c2ccc(cc2)-c2nc3ccncc3c(O)c2C#N)c1Cl Show InChI InChI=1S/C21H13ClN4O/c1-12-19(22)15(6-9-25-12)13-2-4-14(5-3-13)20-16(10-23)21(27)17-11-24-8-7-18(17)26-20/h2-9,11H,1H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365481 (CHEMBL1957367) Show SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1ccccc1OCC#N Show InChI InChI=1S/C23H14N4O2/c24-10-12-29-21-4-2-1-3-17(21)15-5-7-16(8-6-15)22-18(13-25)23(28)19-14-26-11-9-20(19)27-22/h1-9,11,14H,12H2,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365484 (CHEMBL1955881) Show SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1ccccc1C(F)(F)F Show InChI InChI=1S/C22H12F3N3O/c23-22(24,25)18-4-2-1-3-15(18)13-5-7-14(8-6-13)20-16(11-26)21(29)17-12-27-10-9-19(17)28-20/h1-10,12H,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365487 (CHEMBL1957375) Show SMILES CC(C)c1ccccc1-c1ccc(cc1)-c1nc2ccncc2c(O)c1C#N Show InChI InChI=1S/C24H19N3O/c1-15(2)18-5-3-4-6-19(18)16-7-9-17(10-8-16)23-20(13-25)24(28)21-14-26-12-11-22(21)27-23/h3-12,14-15H,1-2H3,(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50209531 ((R)-2-[3-cyano-2-(2'-ethoxy-biphenyl-4-yl)-6-fluor...) Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1nc2ccc(F)cc2c(N[C@H](C)C(O)=O)c1C#N Show InChI InChI=1S/C27H22FN3O3/c1-3-34-24-7-5-4-6-20(24)17-8-10-18(11-9-17)25-22(15-29)26(30-16(2)27(32)33)21-14-19(28)12-13-23(21)31-25/h4-14,16H,3H2,1-2H3,(H,30,31)(H,32,33)/t16-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365483 (CHEMBL1957369) Show SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1ccccc1Cl Show InChI InChI=1S/C21H12ClN3O/c22-18-4-2-1-3-15(18)13-5-7-14(8-6-13)20-16(11-23)21(26)17-12-24-10-9-19(17)25-20/h1-10,12H,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365486 (CHEMBL1957374) Show SMILES CCc1ccccc1-c1ccc(cc1)-c1nc2ccncc2c(O)c1C#N Show InChI InChI=1S/C23H17N3O/c1-2-15-5-3-4-6-18(15)16-7-9-17(10-8-16)22-19(13-24)23(27)20-14-25-12-11-21(20)26-22/h3-12,14H,2H2,1H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365476 (CHEMBL1957361) Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1nc2ccncc2c(O)c1C#N Show InChI InChI=1S/C23H17N3O2/c1-2-28-21-6-4-3-5-17(21)15-7-9-16(10-8-15)22-18(13-24)23(27)19-14-25-12-11-20(19)26-22/h3-12,14H,2H2,1H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365479 (CHEMBL1957364) Show SMILES COc1ccccc1-c1ccc(cc1)-c1nc2ccncc2c(O)c1C#N Show InChI InChI=1S/C22H15N3O2/c1-27-20-5-3-2-4-16(20)14-6-8-15(9-7-14)21-17(12-23)22(26)18-13-24-11-10-19(18)25-21/h2-11,13H,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365500 (CHEMBL1957462) Show SMILES Cc1nn(C)c(C)c1-c1ccc(cc1)-c1nc2ccncc2c(O)c1C#N Show InChI InChI=1S/C21H17N5O/c1-12-19(13(2)26(3)25-12)14-4-6-15(7-5-14)20-16(10-22)21(27)17-11-23-9-8-18(17)24-20/h4-9,11H,1-3H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020015 (CHEMBL3287814) Show SMILES COc1ccc(NC(=N)c2ccc(Cl)cc2)cc1CSC1CCCC1 Show InChI InChI=1S/C20H23ClN2OS/c1-24-19-11-10-17(12-15(19)13-25-18-4-2-3-5-18)23-20(22)14-6-8-16(21)9-7-14/h6-12,18H,2-5,13H2,1H3,(H2,22,23)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020014 (CHEMBL3287813) Show SMILES COc1ccc(NC(=N)c2ccc(Br)s2)cc1CSC1CCCC1 Show InChI InChI=1S/C18H21BrN2OS2/c1-22-15-7-6-13(21-18(20)16-8-9-17(19)24-16)10-12(15)11-23-14-4-2-3-5-14/h6-10,14H,2-5,11H2,1H3,(H2,20,21)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020011 (CHEMBL3287810) Show SMILES COc1ccc(NC(=N)c2ccccc2)cc1CSC1CCCC1 Show InChI InChI=1S/C20H24N2OS/c1-23-19-12-11-17(22-20(21)15-7-3-2-4-8-15)13-16(19)14-24-18-9-5-6-10-18/h2-4,7-8,11-13,18H,5-6,9-10,14H2,1H3,(H2,21,22)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365485 (CHEMBL1957373) Show SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1ccccc1C#N Show InChI InChI=1S/C22H12N4O/c23-11-16-3-1-2-4-17(16)14-5-7-15(8-6-14)21-18(12-24)22(27)19-13-25-10-9-20(19)26-21/h1-10,13H,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365482 (CHEMBL1957368) Show SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1ccccc1F Show InChI InChI=1S/C21H12FN3O/c22-18-4-2-1-3-15(18)13-5-7-14(8-6-13)20-16(11-23)21(26)17-12-24-10-9-19(17)25-20/h1-10,12H,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020011 (CHEMBL3287810) Show SMILES COc1ccc(NC(=N)c2ccccc2)cc1CSC1CCCC1 Show InChI InChI=1S/C20H24N2OS/c1-23-19-12-11-17(22-20(21)15-7-3-2-4-8-15)13-16(19)14-24-18-9-5-6-10-18/h2-4,7-8,11-13,18H,5-6,9-10,14H2,1H3,(H2,21,22)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365494 (CHEMBL1957381) Show SMILES Cc1cc(ccn1)-c1ccc(cc1)-c1nc2ccncc2c(O)c1C#N Show InChI InChI=1S/C21H14N4O/c1-13-10-16(6-9-24-13)14-2-4-15(5-3-14)20-17(11-22)21(26)18-12-23-8-7-19(18)25-20/h2-10,12H,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365496 (CHEMBL1957370) Show SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1ccncc1Cl Show InChI InChI=1S/C20H11ClN4O/c21-17-11-24-7-5-14(17)12-1-3-13(4-2-12)19-15(9-22)20(26)16-10-23-8-6-18(16)25-19/h1-8,10-11H,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM31589 (triaryl imidazole, 1) Show SMILES COc1ccc(cc1)-c1nc([nH]c1-c1ccc(OC)cc1)-c1cccs1 Show InChI InChI=1S/C21H18N2O2S/c1-24-16-9-5-14(6-10-16)19-20(15-7-11-17(25-2)12-8-15)23-21(22-19)18-4-3-13-26-18/h3-13H,1-2H3,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM14754 (1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoq...) Show SMILES COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC Show InChI InChI=1S/C20H21NO4/c1-22-17-6-5-13(10-18(17)23-2)9-16-15-12-20(25-4)19(24-3)11-14(15)7-8-21-16/h5-8,10-12H,9H2,1-4H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020015 (CHEMBL3287814) Show SMILES COc1ccc(NC(=N)c2ccc(Cl)cc2)cc1CSC1CCCC1 Show InChI InChI=1S/C20H23ClN2OS/c1-24-19-11-10-17(12-15(19)13-25-18-4-2-3-5-18)23-20(22)14-6-8-16(21)9-7-14/h6-12,18H,2-5,13H2,1H3,(H2,22,23)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50019982 (CHEMBL3287584) Show SMILES COc1ccc(NC(=N)c2cccs2)cc1CSC1CCCC1 Show InChI InChI=1S/C18H22N2OS2/c1-21-16-9-8-14(20-18(19)17-7-4-10-22-17)11-13(16)12-23-15-5-2-3-6-15/h4,7-11,15H,2-3,5-6,12H2,1H3,(H2,19,20)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365492 (CHEMBL1957379) Show SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1ccncc1 Show InChI InChI=1S/C20H12N4O/c21-11-16-19(24-18-7-10-23-12-17(18)20(16)25)15-3-1-13(2-4-15)14-5-8-22-9-6-14/h1-10,12H,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020012 (CHEMBL3287811) Show SMILES COc1ccc(NC(=N)c2cc(C)cs2)cc1CSC1CCCC1 Show InChI InChI=1S/C19H24N2OS2/c1-13-9-18(24-11-13)19(20)21-15-7-8-17(22-2)14(10-15)12-23-16-5-3-4-6-16/h7-11,16H,3-6,12H2,1-2H3,(H2,20,21)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365478 (CHEMBL1957363) Show SMILES Oc1ccccc1-c1ccc(cc1)-c1nc2ccncc2c(O)c1C#N Show InChI InChI=1S/C21H13N3O2/c22-11-16-20(24-18-9-10-23-12-17(18)21(16)26)14-7-5-13(6-8-14)15-3-1-2-4-19(15)25/h1-10,12,25H,(H,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365490 (CHEMBL1957377) Show SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1ccccc1CN1CCOCC1 Show InChI InChI=1S/C26H22N4O2/c27-15-22-25(29-24-9-10-28-16-23(24)26(22)31)19-7-5-18(6-8-19)21-4-2-1-3-20(21)17-30-11-13-32-14-12-30/h1-10,16H,11-14,17H2,(H,29,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	67	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50019983 (CHEMBL3287585) Show SMILES COc1ccc(Cl)cc1NS(=O)(=O)c1ccc(OC)c2C[C@@H](CCc12)N(C)C |r| Show InChI InChI=1S/C20H25ClN2O4S/c1-23(2)14-6-7-15-16(12-14)18(26-3)9-10-20(15)28(24,25)22-17-11-13(21)5-8-19(17)27-4/h5,8-11,14,22H,6-7,12H2,1-4H3/t14-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50019983 (CHEMBL3287585) Show SMILES COc1ccc(Cl)cc1NS(=O)(=O)c1ccc(OC)c2C[C@@H](CCc12)N(C)C |r| Show InChI InChI=1S/C20H25ClN2O4S/c1-23(2)14-6-7-15-16(12-14)18(26-3)9-10-20(15)28(24,25)22-17-11-13(21)5-8-19(17)27-4/h5,8-11,14,22H,6-7,12H2,1-4H3/t14-/m1/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365493 (CHEMBL1957380) Show SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1cccnc1 Show InChI InChI=1S/C20H12N4O/c21-10-16-19(24-18-7-9-23-12-17(18)20(16)25)14-5-3-13(4-6-14)15-2-1-8-22-11-15/h1-9,11-12H,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020010 (CHEMBL3287586) Show SMILES COc1ccc(NC(=N)c2ccsc2)cc1CSC1CCCC1 Show InChI InChI=1S/C18H22N2OS2/c1-21-17-7-6-15(20-18(19)13-8-9-22-11-13)10-14(17)12-23-16-4-2-3-5-16/h6-11,16H,2-5,12H2,1H3,(H2,19,20)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020012 (CHEMBL3287811) Show SMILES COc1ccc(NC(=N)c2cc(C)cs2)cc1CSC1CCCC1 Show InChI InChI=1S/C19H24N2OS2/c1-13-9-18(24-11-13)19(20)21-15-7-8-17(22-2)14(10-15)12-23-16-5-3-4-6-16/h7-11,16H,3-6,12H2,1-2H3,(H2,20,21)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365488 (CHEMBL1957365) Show SMILES OCc1ccccc1-c1ccc(cc1)-c1nc2ccncc2c(O)c1C#N Show InChI InChI=1S/C22H15N3O2/c23-11-18-21(25-20-9-10-24-12-19(20)22(18)27)15-7-5-14(6-8-15)17-4-2-1-3-16(17)13-26/h1-10,12,26H,13H2,(H,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	108	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020010 (CHEMBL3287586) Show SMILES COc1ccc(NC(=N)c2ccsc2)cc1CSC1CCCC1 Show InChI InChI=1S/C18H22N2OS2/c1-21-17-7-6-15(20-18(19)13-8-9-22-11-13)10-14(17)12-23-16-4-2-3-5-16/h6-11,16H,2-5,12H2,1H3,(H2,19,20)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020014 (CHEMBL3287813) Show SMILES COc1ccc(NC(=N)c2ccc(Br)s2)cc1CSC1CCCC1 Show InChI InChI=1S/C18H21BrN2OS2/c1-22-15-7-6-13(21-18(20)16-8-9-17(19)24-16)10-12(15)11-23-14-4-2-3-5-14/h6-10,14H,2-5,11H2,1H3,(H2,20,21)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365489 (CHEMBL1957376) Show SMILES CN(C)Cc1ccccc1-c1ccc(cc1)-c1nc2ccncc2c(O)c1C#N Show InChI InChI=1S/C24H20N4O/c1-28(2)15-18-5-3-4-6-19(18)16-7-9-17(10-8-16)23-20(13-25)24(29)21-14-26-12-11-22(21)27-23/h3-12,14H,15H2,1-2H3,(H,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	144	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50019982 (CHEMBL3287584) Show SMILES COc1ccc(NC(=N)c2cccs2)cc1CSC1CCCC1 Show InChI InChI=1S/C18H22N2OS2/c1-21-16-9-8-14(20-18(19)17-7-4-10-22-17)11-13(16)12-23-15-5-2-3-6-15/h4,7-11,15H,2-3,5-6,12H2,1H3,(H2,19,20)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020013 (CHEMBL3287812) Show SMILES COc1ccc(NC(=N)c2cc(Br)cs2)cc1CSC1CCCC1 Show InChI InChI=1S/C18H21BrN2OS2/c1-22-16-7-6-14(21-18(20)17-9-13(19)11-24-17)8-12(16)10-23-15-4-2-3-5-15/h6-9,11,15H,2-5,10H2,1H3,(H2,20,21)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM50365480 (CHEMBL1957366) Show SMILES Oc1c(C#N)c(nc2ccncc12)-c1ccc(cc1)-c1ccccc1OC(F)(F)F Show InChI InChI=1S/C22H12F3N3O2/c23-22(24,25)30-19-4-2-1-3-15(19)13-5-7-14(8-6-13)20-16(11-26)21(29)17-12-27-10-9-18(17)28-20/h1-10,12H,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant DHODH transmembrane domain using 2,6-dichloroindophenol sodium, L-Dihydroorotic acid, and decylubiquinone as substrat...				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50019979 (CHEMBL3287833) Show SMILES COc1ccc(NC(=N)c2ccccc2)cc1CCC1CCCC1 Show InChI InChI=1S/C21H26N2O/c1-24-20-14-13-19(23-21(22)17-9-3-2-4-10-17)15-18(20)12-11-16-7-5-6-8-16/h2-4,9-10,13-16H,5-8,11-12H2,1H3,(H2,22,23)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020020 (CHEMBL3287819) Show SMILES COc1ccc(NC(=N)c2cccnc2)cc1CSC1CCCC1 Show InChI InChI=1S/C19H23N3OS/c1-23-18-9-8-16(22-19(20)14-5-4-10-21-12-14)11-15(18)13-24-17-6-2-3-7-17/h4-5,8-12,17H,2-3,6-7,13H2,1H3,(H2,20,22)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020022 (CHEMBL3287821) Show SMILES COc1ccc(N\C(=N\C)c2cccs2)cc1CSC1CCCC1 Show InChI InChI=1S/C19H24N2OS2/c1-20-19(18-8-5-11-23-18)21-15-9-10-17(22-2)14(12-15)13-24-16-6-3-4-7-16/h5,8-12,16H,3-4,6-7,13H2,1-2H3,(H,20,21)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365477 (CHEMBL1957362) Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1nc2ccncc2c(OC)c1C#N Show InChI InChI=1S/C24H19N3O2/c1-3-29-22-7-5-4-6-18(22)16-8-10-17(11-9-16)23-19(14-25)24(28-2)20-15-26-13-12-21(20)27-23/h4-13,15H,3H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	315	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50019979 (CHEMBL3287833) Show SMILES COc1ccc(NC(=N)c2ccccc2)cc1CCC1CCCC1 Show InChI InChI=1S/C21H26N2O/c1-24-20-14-13-19(23-21(22)17-9-3-2-4-10-17)15-18(20)12-11-16-7-5-6-8-16/h2-4,9-10,13-16H,5-8,11-12H2,1H3,(H2,22,23)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365491 (CHEMBL1957378) Show SMILES Cc1c(O)c2cnccc2nc1-c1ccc(cc1)-c1ccccc1OCC#N Show InChI InChI=1S/C23H17N3O2/c1-15-22(26-20-10-12-25-14-19(20)23(15)27)17-8-6-16(7-9-17)18-4-2-3-5-21(18)28-13-11-24/h2-10,12,14H,13H2,1H3,(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	456	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020020 (CHEMBL3287819) Show SMILES COc1ccc(NC(=N)c2cccnc2)cc1CSC1CCCC1 Show InChI InChI=1S/C19H23N3OS/c1-23-18-9-8-16(22-19(20)14-5-4-10-21-12-14)11-15(18)13-24-17-6-2-3-7-17/h4-5,8-12,17H,2-3,6-7,13H2,1H3,(H2,20,22)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	501	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50019976 (CHEMBL3287827) Show SMILES Fc1ccc(NC(=N)c2cccs2)cc1CSC1CCCC1 Show InChI InChI=1S/C17H19FN2S2/c18-15-8-7-13(20-17(19)16-6-3-9-21-16)10-12(15)11-22-14-4-1-2-5-14/h3,6-10,14H,1-2,4-5,11H2,(H2,19,20)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	501	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Antagonist activity at human GPR103 receptor assessed as inhibition of inositol-1-phosphate production by cell-based assay				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365475 (CHEMBL1957360) Show SMILES CCOc1ccccc1-c1ccc(cc1)-c1cc(O)c2cnccc2n1 Show InChI InChI=1S/C22H18N2O2/c1-2-26-22-6-4-3-5-17(22)15-7-9-16(10-8-15)20-13-21(25)18-14-23-12-11-19(18)24-20/h3-14H,2H2,1H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	561	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM50365499 (CHEMBL1957461) Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1nc2ccncc2c(O)c1C#N Show InChI InChI=1S/C19H13N5O/c1-24-11-14(9-22-24)12-2-4-13(5-3-12)18-15(8-20)19(25)16-10-21-7-6-17(16)23-18/h2-7,9-11H,1H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	608	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human recombinant full length PDE10A using cAMP as substrate preincubated for 20 mins measured after 4 hrs				Bioorg Med Chem Lett 22: 1944-8 (2012) Article DOI: 10.1016/j.bmcl.2012.01.046 BindingDB Entry DOI: 10.7270/Q2KH0NTP
					More data for this Ligand-Target Pair
Pyroglutamylated RF-amide peptide receptor (Homo sapiens (Human))	BDBM50020022 (CHEMBL3287821) Show SMILES COc1ccc(N\C(=N\C)c2cccs2)cc1CSC1CCCC1 Show InChI InChI=1S/C19H24N2OS2/c1-20-19(18-8-5-11-23-18)21-15-9-10-17(22-2)14(12-15)13-24-16-6-3-4-7-16/h5,8-12,16H,3-4,6-7,13H2,1-2H3,(H,20,21)	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Displacement of [125I]-QRFP43 from human GPR103 receptor overexpressed in HEK membranes after 90 mins by liquid scintillation counting				ACS Med Chem Lett 5: 527-32 (2014) Article DOI: 10.1021/ml400519h BindingDB Entry DOI: 10.7270/Q2V989NR
					More data for this Ligand-Target Pair

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