Found 79 hits with Last Name = 'kaliszczak' and Initial = 'm' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326519
((E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CNCC#C Show InChI InChI=1S/C25H21ClFN5O2/c1-3-9-29-10-5-6-24(33)32-22-12-18-21(13-23(22)34-4-2)30-15-16(14-28)25(18)31-17-7-8-20(27)19(26)11-17/h1,5-8,11-13,15,29H,4,9-10H2,2H3,(H,30,31)(H,32,33)/b6-5+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM31090
((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C Show InChI InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326514
((E)-4-(Methylamino)-but-2-enoic acid [4-(3-chloro-...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CNC Show InChI InChI=1S/C23H21ClFN5O2/c1-3-32-21-11-19-16(10-20(21)30-22(31)5-4-8-27-2)23(14(12-26)13-28-19)29-15-6-7-18(25)17(24)9-15/h4-7,9-11,13,27H,3,8H2,1-2H3,(H,28,29)(H,30,31)/b5-4+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326513
((E)-4-Methylamino-but-2-enoicacid[4-(3-chloro-4-fl...)Show SMILES CNC\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)c(cnc2cc1OCCF)C#N Show InChI InChI=1S/C23H20ClF2N5O2/c1-28-7-2-3-22(32)31-20-10-16-19(11-21(20)33-8-6-25)29-13-14(12-27)23(16)30-15-4-5-18(26)17(24)9-15/h2-5,9-11,13,28H,6-8H2,1H3,(H,29,30)(H,31,32)/b3-2+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.290 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326517
((E)-4-[(4-Fluorobenzyl)methylamino]-but-2-enoic ac...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)Cc1ccc(F)cc1 Show InChI InChI=1S/C30H26ClF2N5O2/c1-3-40-28-15-26-23(30(20(16-34)17-35-26)36-22-10-11-25(33)24(31)13-22)14-27(28)37-29(39)5-4-12-38(2)18-19-6-8-21(32)9-7-19/h4-11,13-15,17H,3,12,18H2,1-2H3,(H,35,36)(H,37,39)/b5-4+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.570 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326518
((E)-4-[(2-Fluoroethyl)methylamino]-but-2-enoic aci...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)CCF Show InChI InChI=1S/C25H24ClF2N5O2/c1-3-35-23-13-21-18(12-22(23)32-24(34)5-4-9-33(2)10-8-27)25(16(14-29)15-30-21)31-17-6-7-20(28)19(26)11-17/h4-7,11-13,15H,3,8-10H2,1-2H3,(H,30,31)(H,32,34)/b5-4+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3303
(4-Anilinoquinazoline deriv. 54 | 4-N-(3-bromopheny...)Show InChI InChI=1S/C14H12BrN5/c15-8-2-1-3-9(4-8)20-14-10-5-11(16)12(17)6-13(10)18-7-19-14/h1-7H,16-17H2,(H,18,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326516
((E)-4-{[1-(2-Fluoroethyl)-1H-[1,2,3]triazol-4-ylme...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CNCc1cn(CCF)nn1 Show InChI InChI=1S/C27H25ClF2N8O2/c1-2-40-25-12-23-20(27(17(13-31)14-33-23)34-18-5-6-22(30)21(28)10-18)11-24(25)35-26(39)4-3-8-32-15-19-16-38(9-7-29)37-36-19/h3-6,10-12,14,16,32H,2,7-9,15H2,1H3,(H,33,34)(H,35,39)/b4-3+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.81 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326515
((E)-N-[4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\c1cn(CCF)nn1 Show InChI InChI=1S/C25H20ClF2N7O2/c1-2-37-23-11-21-18(10-22(23)32-24(36)6-4-17-14-35(8-7-27)34-33-17)25(15(12-29)13-30-21)31-16-3-5-20(28)19(26)9-16/h3-6,9-11,13-14H,2,7-8H2,1H3,(H,30,31)(H,32,36)/b6-4+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.05 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326514
((E)-4-(Methylamino)-but-2-enoic acid [4-(3-chloro-...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CNC Show InChI InChI=1S/C23H21ClFN5O2/c1-3-32-21-11-19-16(10-20(21)30-22(31)5-4-8-27-2)23(14(12-26)13-28-19)29-15-6-7-18(25)17(24)9-15/h4-7,9-11,13,27H,3,8H2,1-2H3,(H,28,29)(H,30,31)/b5-4+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.35 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in human A431 cells |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM31090
((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C Show InChI InChI=1S/C24H23ClFN5O2/c1-4-33-22-12-20-17(11-21(22)30-23(32)6-5-9-31(2)3)24(15(13-27)14-28-20)29-16-7-8-19(26)18(25)10-16/h5-8,10-12,14H,4,9H2,1-3H3,(H,28,29)(H,30,32)/b6-5+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.02 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in human A431 cells |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326513
((E)-4-Methylamino-but-2-enoicacid[4-(3-chloro-4-fl...)Show SMILES CNC\C=C\C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)c(cnc2cc1OCCF)C#N Show InChI InChI=1S/C23H20ClF2N5O2/c1-28-7-2-3-22(32)31-20-10-16-19(11-21(20)33-8-6-25)29-13-14(12-27)23(16)30-15-4-5-18(26)17(24)9-15/h2-5,9-11,13,28H,6-8H2,1H3,(H,29,30)(H,31,32)/b3-2+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.12 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in human A431 cells |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326517
((E)-4-[(4-Fluorobenzyl)methylamino]-but-2-enoic ac...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)Cc1ccc(F)cc1 Show InChI InChI=1S/C30H26ClF2N5O2/c1-3-40-28-15-26-23(30(20(16-34)17-35-26)36-22-10-11-25(33)24(31)13-22)14-27(28)37-29(39)5-4-12-38(2)18-19-6-8-21(32)9-7-19/h4-11,13-15,17H,3,12,18H2,1-2H3,(H,35,36)(H,37,39)/b5-4+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in human A431 cells |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326516
((E)-4-{[1-(2-Fluoroethyl)-1H-[1,2,3]triazol-4-ylme...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CNCc1cn(CCF)nn1 Show InChI InChI=1S/C27H25ClF2N8O2/c1-2-40-25-12-23-20(27(17(13-31)14-33-23)34-18-5-6-22(30)21(28)10-18)11-24(25)35-26(39)4-3-8-32-15-19-16-38(9-7-29)37-36-19/h3-6,10-12,14,16,32H,2,7-9,15H2,1H3,(H,33,34)(H,35,39)/b4-3+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22.0 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in human A431 cells |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586324
(CHEMBL5085284)Show SMILES C[C@@H](CN1CCC2(CC1)OC(=O)NC[C@H]2c1cccc(F)c1)NC(=O)c1ccc(F)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326518
((E)-4-[(2-Fluoroethyl)methylamino]-but-2-enoic aci...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)CCF Show InChI InChI=1S/C25H24ClF2N5O2/c1-3-35-23-13-21-18(12-22(23)32-24(34)5-4-9-33(2)10-8-27)25(16(14-29)15-30-21)31-17-6-7-20(28)19(26)11-17/h4-7,11-13,15H,3,8-10H2,1-2H3,(H,30,31)(H,32,34)/b5-4+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 23.0 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in human A431 cells |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586314
(CHEMBL5078848)Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)NC(=O)c1ccc(F)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586336
(CHEMBL5092677)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1C[C@H](C)N[C@H](C)C1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586327
(CHEMBL5078394)Show SMILES C[C@@H](CN1CCC(CC1)n1c2ccccc2[nH]c1=O)n1ccccc1=O |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586337
(CHEMBL5085809)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1C[C@@H](C)N[C@H](C)C1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
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| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM154517
(ML299 (5))Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc(Br)cc1 Show InChI InChI=1S/C23H26BrFN4O2/c1-16(27-21(30)17-5-7-18(24)8-6-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)20-4-2-3-19(25)13-20/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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| Purchase
MCE
PC cid
PC sid
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326519
((E)-N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CNCC#C Show InChI InChI=1S/C25H21ClFN5O2/c1-3-9-29-10-5-6-24(33)32-22-12-18-21(13-23(22)34-4-2)30-15-16(14-28)25(18)31-17-7-8-20(27)19(26)11-17/h1,5-8,11-13,15,29H,4,9-10H2,2H3,(H,30,31)(H,32,33)/b6-5+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in human A431 cells |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50586324
(CHEMBL5085284)Show SMILES C[C@@H](CN1CCC2(CC1)OC(=O)NC[C@H]2c1cccc(F)c1)NC(=O)c1ccc(F)cc1 |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD2 (unknown origin) expressed in human HEK cells by immunoprecipitation |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586320
(CHEMBL5092708)Show SMILES C[C@@H](CN1CCC2(CC1)OC(=O)Nc1ccccc21)NC(=O)c1ccc(F)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM154517
(ML299 (5))Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1cccc(F)c1)NC(=O)c1ccc(Br)cc1 Show InChI InChI=1S/C23H26BrFN4O2/c1-16(27-21(30)17-5-7-18(24)8-6-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)20-4-2-3-19(25)13-20/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
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| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD2 (unknown origin) expressed in human HEK cells by immunoprecipitation |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586334
(CHEMBL5088048)Show SMILES CC[C@H]1CN(CCN1)C(=O)[C@H](C)N1CCC(CC1)n1c2ccccc2[nH]c1=O |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586321
(CHEMBL5083605)Show SMILES C[C@@H](CN1CCC2(CC1)OC(=O)Nc1cc(F)ccc21)NC(=O)c1ccc(F)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586331
(CHEMBL5086717)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1CCN[C@@H](C)C1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586329
(CHEMBL5074314)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1C[C@@H](C)c2ccccc2C1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586322
(CHEMBL5092706)Show SMILES C[C@@H](CN1CCC2(CC1)OC(=O)Nc1ccncc21)NC(=O)c1ccc(F)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586326
(CHEMBL5075520) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586325
(CHEMBL5076666)Show SMILES CN(CCN1CCC(CC1)n1c2ccc(Cl)cc2[nH]c1=O)C(C)=O | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586335
(CHEMBL5080858)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1CCNC[C@H]1C |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586328
(CHEMBL5086297)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1CCC(F)(F)C1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50586336
(CHEMBL5092677)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1C[C@H](C)N[C@H](C)C1 |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD2 (unknown origin) expressed in human HEK cells by immunoprecipitation |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586323
(CHEMBL5080277)Show SMILES C[C@@H](CN1CCC2(CC1)OC(=O)Nc1cccnc21)NC(=O)c1ccc(F)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50586337
(CHEMBL5085809)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1C[C@@H](C)N[C@H](C)C1 |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD2 (unknown origin) expressed in human HEK cells by immunoprecipitation |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586318
(CHEMBL5080618)Show SMILES C[C@@H](CN1CCC2(CC1)NC(=O)Nc1ccccc21)NC(=O)c1ccc(F)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50586329
(CHEMBL5074314)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1C[C@@H](C)c2ccccc2C1 |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD2 (unknown origin) expressed in human HEK cells by immunoprecipitation |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586332
(CHEMBL5080871)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1CCN[C@H](C)C1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586333
(CHEMBL5081973)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1CCNC(C)(C)C1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586330
(CHEMBL5093394)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1CCOCC1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586317
(CHEMBL5090919)Show SMILES C[C@@H](CN1CCC2(CC1)CC(=O)Nc1ccccc21)NC(=O)c1ccc(F)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50586334
(CHEMBL5088048)Show SMILES CC[C@H]1CN(CCN1)C(=O)[C@H](C)N1CCC(CC1)n1c2ccccc2[nH]c1=O |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD2 (unknown origin) expressed in human HEK cells by immunoprecipitation |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586316
(CHEMBL5085765)Show SMILES C[C@@H](CN1CCC(CC1)c1n[nH]c2ccccc12)NC(=O)c1ccc(F)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50586321
(CHEMBL5083605)Show SMILES C[C@@H](CN1CCC2(CC1)OC(=O)Nc1cc(F)ccc21)NC(=O)c1ccc(F)cc1 |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD2 (unknown origin) expressed in human HEK cells by immunoprecipitation |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50326515
((E)-N-[4-(3-Chloro-4-fluorophenylamino)-3-cyano-7-...)Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\c1cn(CCF)nn1 Show InChI InChI=1S/C25H20ClF2N7O2/c1-2-37-23-11-21-18(10-22(23)32-24(36)6-4-17-14-35(8-7-27)34-33-17)25(15(12-29)13-30-21)31-16-3-5-20(28)19(26)9-16/h3-6,9-11,13-14H,2,7-8H2,1H3,(H,30,31)(H,32,36)/b6-4+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in human A431 cells |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM3303
(4-Anilinoquinazoline deriv. 54 | 4-N-(3-bromopheny...)Show InChI InChI=1S/C14H12BrN5/c15-8-2-1-3-9(4-8)20-14-10-5-11(16)12(17)6-13(10)18-7-19-14/h1-7H,16-17H2,(H,18,19,20) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Imperial College London
Curated by ChEMBL
| Assay Description
Inhibition of EGFR autophosphorylation in human A431 cells |
Bioorg Med Chem 18: 6634-45 (2010)
Article DOI: 10.1016/j.bmc.2010.08.004
BindingDB Entry DOI: 10.7270/Q25H7GG2 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50586331
(CHEMBL5086717)Show SMILES C[C@H](N1CCC(CC1)n1c2ccccc2[nH]c1=O)C(=O)N1CCN[C@@H](C)C1 |r| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD2 (unknown origin) expressed in human HEK cells by immunoprecipitation |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50586312
(CHEMBL5094742)Show SMILES C[C@@H](CN1CCC(CC1)N1C(=O)Cc2ccccc12)NC(=O)c1ccc(F)cc1 |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay |
Bioorg Med Chem Lett 14: 5877-80 (2004)
Article DOI: 10.1021/acsmedchemlett.1c00682
BindingDB Entry DOI: 10.7270/Q27H1PGW |
More data for this
Ligand-Target Pair | |
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