Compile Data Set for Download or QSAR

Found 983 hits with Last Name = 'karki' and Initial = 'rg'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Complement factor B (Homo sapiens (Human))	BDBM160485 (US9682968, Example-27-4a (+)) Show SMILES CCOC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)C(C1)c1ccc(cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160475 (US10093663, Example 26b | US9682968, Example-26a) Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160272 (US9682968, Example-22-2b (-)) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCC(C)(C)CC1c1ccc(cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159970 (US10093663, Example 20a | US9682968, Example-20a) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC[C@@H](C)C[C@H]1c1ccc(cc1)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159545 (US10093663, Example 17-30 | US9682968, Example-17-...) Show SMILES CCC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159938 (US10093663, Example 17-29 | US9682968, Example-17-...) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCC2(CC2)CC1c1ccc(cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160483 (US9682968, Example-27-3a (-)) Show SMILES COC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)C(C1)c1ccc(cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160500 (US10093663, Example 37 | US9682968, Example-37) Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)NS(C)(=O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159545 (US10093663, Example 17-30 | US9682968, Example-17-...) Show SMILES CCC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160481 (US9682968, Example-27-2a (+)) Show SMILES CCOC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160480 (US9682968, Example-27-1b (-)) Show SMILES COC1CCN(Cc2c(C)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160102 (US9682968, Example-22-1a (-)) Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(nc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160036 (US10093663, Example 21a | US9682968, Example-21a) Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160499 (US10093663, Example 36 | US9682968, Example-36) Show SMILES CCOC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(cc1)-c1nn[nH]n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159486 (US10093663, Example 17-11 | US9682968, Example-17-...) Show SMILES CCCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159312 (US10093663, Example 17-1 | US9682968, Example-17-1) Show SMILES Cc1cc(C2CC2)c(CN2CCCC[C@H]2c2ccc(cc2)C(O)=O)c2cc[nH]c12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159319 (US9682968, Example-17-5) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cc1)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM155343 (US9006249, Example 49-2 | US9603819, Example 49-2) Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(n[nH]1)C(O)=O)C(O)=O |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description See A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7 Doering K, Meder G, Hinnenberger M, Woelcke J, Mayr L ...				US Patent US9006249 (2015) BindingDB Entry DOI: 10.7270/Q2NV9H0R
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159566 (US10093663, Example 17-18 | US9682968, Example-17-...) Show SMILES COC1CCN(Cc2c(cc(C)c3[nH]ccc23)C2CC2)C(C1)c1ccc(nc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159311 (US10093663, Example 16 | US9682968, Example-16) Show SMILES Cc1cc(C2CC2)c(CN2CCCC[C@H]2c2ccc(C(O)=O)c(F)c2)c2cc[nH]c12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159289 (US10093663, Example 5-12 | US9682968, Example-5-12) Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)-c1nn[nH]n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159873 (US10093663, Example 17-24 | US9682968, Example-17-...) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cc1)-c1cc[nH]n1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159314 (US9682968, Example-17-3) Show SMILES Cc1cc(C2CC2)c(CN2CCCC[C@H]2c2ccc(nc2)C(O)=O)c2cc[nH]c12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM153121 (US8993631, 29-2 | US9006249, Example 49-1) Show SMILES C[C@@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)no1)C(O)=O Show InChI InChI=1S/C22H21ClN2O5/c1-13(22(28)29)9-18(24-21(27)19-12-20(26)25-30-19)10-14-5-7-15(8-6-14)16-3-2-4-17(23)11-16/h2-8,11-13,18H,9-10H2,1H3,(H,24,27)(H,25,26)(H,28,29)/t13-,18-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description See A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7 Doering K, Meder G, Hinnenberger M, Woelcke J, Mayr L ...				US Patent US9006249 (2015) BindingDB Entry DOI: 10.7270/Q2NV9H0R
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160474 (US9682968, Example-25b (-)) Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159920 (US10093663, Example 17-25 | US9682968, Example-17-...) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(C(O)=O)c2ccccc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159509 (US10093663, Example 17-13 | US9682968, Example-17-...) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1C)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160506 (US10093663, Example 40 | US9682968, Example-40) Show SMILES CC(=O)NS(=O)(=O)c1ccc(cc1)C1CCCCN1Cc1c(cc(C)c2[nH]ccc12)C1CC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Membrane metallo-endopeptidase-like 1 (Homo sapiens (Human))	BDBM130367 (US8822534, Example 11-14) Show SMILES OC(=O)C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1cc(O)no1 Show InChI InChI=1S/C20H17ClN2O5/c21-15-3-1-2-14(9-15)13-6-4-12(5-7-13)8-16(10-19(25)26)22-20(27)17-11-18(24)23-28-17/h1-7,9,11,16H,8,10H2,(H,22,27)(H,23,24)(H,25,26)/t16-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...				US Patent US8822534 (2014) BindingDB Entry DOI: 10.7270/Q2513WW2
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159379 (US10093663, Example 17-8 | US9682968, Example-17-8) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cc1F)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159316 (US9682968, Example-17-4) Show SMILES COc1cc(ccc1[C@@H]1CCCCN1Cc1c(cc(C)c2[nH]ccc12)C1CC1)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159841 (US10093663, Example 17-22 | US9682968, Example-17-...) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCCC1c1ccc(cc1)C(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159382 (US10093663, Example 17-10 | US9682968, Example-17-...) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCC[C@H]1c1ccc(cn1)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159313 (US9682968, Example-17-2) Show SMILES Cc1cc(C2CC2)c(CN2CCCC2c2ccc(cc2)C(O)=O)c2cc[nH]c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160501 (US10093663, Example 38 | US9682968, Example-38) Show SMILES CNC(=O)c1ccc(cc1)[C@@H]1C[C@H](CCN1Cc1c(OC)cc(C)c2[nH]ccc12)OC |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159303 (US10093663, Example 13 | US9682968, Example-13) Show SMILES Cc1cc(Cl)c(CN2CCCCC2c2ccc(cc2)C(O)=O)c2cc[nH]c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159932 (US10093663, Example 17-28 | US9682968, Example-17-...) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(C(O)=O)c(OC)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.160	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160507 (US9682968, Example-41) Show SMILES CCNC(=O)c1ccc(cc1)[C@@H]1C[C@H](C)CCN1Cc1c(OC)cc(C)c2[nH]ccc12 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159157 (US10093663, Example 5-4 | US9682968, Example-5-4) Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)S(N)(=O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.180	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Membrane metallo-endopeptidase-like 1 (Homo sapiens (Human))	BDBM130365 (US8822534, Example 11-1 | US8822534, Example 12-1 ...) Show SMILES OC(=O)CCC(=O)N[C@@H](CC(O)=O)Cc1ccc(cc1)-c1cccc(Cl)c1 Show InChI InChI=1S/C20H20ClNO5/c21-16-3-1-2-15(11-16)14-6-4-13(5-7-14)10-17(12-20(26)27)22-18(23)8-9-19(24)25/h1-7,11,17H,8-10,12H2,(H,22,23)(H,24,25)(H,26,27)/t17-/m1/s1	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description Recombinant human neutral endopeptidase (expressed in insect cells and purified using standard methods, final concentration 7 μM) is pre-incubat...				US Patent US8822534 (2014) BindingDB Entry DOI: 10.7270/Q2513WW2
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159301 (US9682968, Example-11) Show SMILES Cc1cc(C)c2[nH]ccc2c1CN1CCC(O)CC1c1ccc(cc1)C(N)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.230	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160508 (US10093663, Example 42 | US9682968, Example-42) Show SMILES CCO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)OCC |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160504 (US10093663, Example 39-3 | US9682968, Example-39-3) Show SMILES CO[C@H]1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)[C@@H](C1)c1ccc(cc1)C(=O)NCCO |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	0.280	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM159976 (US10093663, Example 20b | US9682968, Example-20b) Show SMILES COc1cc(C)c2[nH]ccc2c1CN1CC[C@H](C)C[C@@H]1c1ccc(cc1)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM153128 (US8993631, 36) Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)CCC(O)=O)C(O)=O Show InChI InChI=1S/C22H24ClNO5/c1-14(22(28)29)11-19(24-20(25)9-10-21(26)27)12-15-5-7-16(8-6-15)17-3-2-4-18(23)13-17/h2-8,13-14,19H,9-12H2,1H3,(H,24,25)(H,26,27)(H,28,29)/t14-,19+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...				ACS Med Chem Lett 11: 188-194 (2020) Article DOI: 10.1021/acsmedchemlett.9b00578 BindingDB Entry DOI: 10.7270/Q2C82DK4
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM155344 (US9006249, Example 49-3 | US9603819, Example 49-3) Show SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)NC(=O)c1ccc(o1)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C24H22ClNO6/c1-14(23(28)29)11-19(26-22(27)20-9-10-21(32-20)24(30)31)12-15-5-7-16(8-6-15)17-3-2-4-18(25)13-17/h2-10,13-14,19H,11-12H2,1H3,(H,26,27)(H,28,29)(H,30,31)/t14-,19+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.4	25
Novartis AG US Patent					Assay Description See A fluorescence lifetime-based assay for protease inhibitor profiling on human kallikrein 7 Doering K, Meder G, Hinnenberger M, Woelcke J, Mayr L ...				US Patent US9006249 (2015) BindingDB Entry DOI: 10.7270/Q2NV9H0R
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160505 (US10093663, Example 39-4 | US9682968, Example-39-4) Show SMILES COCCNC(=O)c1ccc(cc1)[C@@H]1C[C@H](CCN1Cc1c(OC)cc(C)c2[nH]ccc12)OC |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Complement factor B (Homo sapiens (Human))	BDBM160495 (US10093663, Example 32-3 | US9682968, Example-32-3) Show SMILES COC1CCN(Cc2c(OC)cc(C)c3[nH]ccc23)C(C1)c1ccc(CO)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description CVF-Bb complex prepared from purified cobra venom factor (1 μM), recombinant human complement factor B (expressed in drosophila cells and purifi...				US Patent US9682968 (2017) BindingDB Entry DOI: 10.7270/Q2XG9P9J
					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM130359 (US8822534, Example 5-39 | US8993631, 5-8) Show SMILES COc1ccc(Cl)cc1-c1ccc(C[C@H](CC(O)=O)NC(=O)CCC(O)=O)cc1 Show InChI InChI=1S/C21H22ClNO6/c1-29-18-7-6-15(22)11-17(18)14-4-2-13(3-5-14)10-16(12-21(27)28)23-19(24)8-9-20(25)26/h2-7,11,16H,8-10,12H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t16-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.380	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of recombinant human NEP expressed in insect cells preincubated for 1 hr using Cys(PT14)-Arg-Arg-Leu-Trp-OH as substrate and measured afte...				ACS Med Chem Lett 11: 188-194 (2020) Article DOI: 10.1021/acsmedchemlett.9b00578 BindingDB Entry DOI: 10.7270/Q2C82DK4
					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM50542738 (CHEMBL4637027) Show SMILES CC(C)c1cc(cc(c1)-c1ccc2OC[C@@H](N)c2c1)[C@H](O)Cn1ccc2cccc(C(O)=O)c12 |r| Show InChI InChI=1S/C28H28N2O4/c1-16(2)19-10-20(18-6-7-26-23(13-18)24(29)15-34-26)12-21(11-19)25(31)14-30-9-8-17-4-3-5-22(27(17)30)28(32)33/h3-13,16,24-25,31H,14-15,29H2,1-2H3,(H,32,33)/t24-,25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of human F11a using D-Leu-Pro-Arg*Rh110-D-Pro as substrate preincubated for 60 mins followed by substrate addition and measured after 60 m...				J Med Chem 63: 8088-8113 (2020) Article DOI: 10.1021/acs.jmedchem.0c00279 BindingDB Entry DOI: 10.7270/Q2KS6W36
					More data for this Ligand-Target Pair				3D Structure (crystal)

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