Found 158 hits with Last Name = 'kew' and Initial = 'jn' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50376470
(CHEMBL405895)Show SMILES Oc1cc2N=C(CC(=O)Nc2cc1-c1ccccc1F)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C24H17FN4O2/c25-19-7-2-1-6-17(19)18-11-21-22(12-23(18)30)27-20(13-24(31)28-21)15-4-3-5-16(10-15)29-9-8-26-14-29/h1-12,14,30H,13H2,(H,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50376467
(CHEMBL260636)Show SMILES Fc1ccccc1-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:12| Show InChI InChI=1S/C24H17FN4O/c25-20-7-2-1-6-19(20)16-8-9-21-23(13-16)28-24(30)14-22(27-21)17-4-3-5-18(12-17)29-11-10-26-15-29/h1-13,15H,14H2,(H,28,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376487
(CHEMBL261050)Show SMILES CCc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-n1ccnc1 |c:5| Show InChI InChI=1S/C21H17F3N4O/c1-2-13-9-18-19(10-16(13)21(22,23)24)27-20(29)11-17(26-18)14-4-3-5-15(8-14)28-7-6-25-12-28/h3-10,12H,2,11H2,1H3,(H,27,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372881
(CHEMBL256812)Show SMILES Fc1ccc(cc1)C#Cc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnn1 |c:14| Show InChI InChI=1S/C25H16FN5O/c26-20-9-6-17(7-10-20)4-5-18-8-11-22-24(14-18)29-25(32)16-23(28-22)19-2-1-3-21(15-19)31-13-12-27-30-31/h1-3,6-15H,16H2,(H,29,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat recombinant mGluR2 expressed in CHO cells |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376466
(CHEMBL437835)Show SMILES Fc1ccc(F)c(c1)-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:13| Show InChI InChI=1S/C24H16F2N4O/c25-17-5-6-20(26)19(12-17)15-4-7-21-23(11-15)29-24(31)13-22(28-21)16-2-1-3-18(10-16)30-9-8-27-14-30/h1-12,14H,13H2,(H,29,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376471
(CHEMBL408455)Show SMILES CCOc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-n1ccnn1 |c:6| Show InChI InChI=1S/C20H16F3N5O2/c1-2-30-18-10-17-16(9-14(18)20(21,22)23)26-19(29)11-15(25-17)12-4-3-5-13(8-12)28-7-6-24-27-28/h3-10H,2,11H2,1H3,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50379670
(CHEMBL2013195)Show InChI InChI=1S/C19H21N3O/c23-17-10-9-16-18(15(17)13-22-11-5-2-6-12-22)21-19(20-16)14-7-3-1-4-8-14/h1,3-4,7-10,23H,2,5-6,11-13H2,(H,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline R&D
Curated by ChEMBL
| Assay Description Displacement of [3H]-Ro256981 from human NR2B receptor |
Bioorg Med Chem Lett 22: 2620-3 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.108 BindingDB Entry DOI: 10.7270/Q2KD1ZX3 |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50379688
(CHEMBL2013196)Show InChI InChI=1S/C20H23N3O/c24-18-11-10-17-19(16(18)14-23-12-6-1-2-7-13-23)22-20(21-17)15-8-4-3-5-9-15/h3-5,8-11,24H,1-2,6-7,12-14H2,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline R&D
Curated by ChEMBL
| Assay Description Displacement of [3H]-Ro256981 from human NR2B receptor |
Bioorg Med Chem Lett 22: 2620-3 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.108 BindingDB Entry DOI: 10.7270/Q2KD1ZX3 |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50379671
(CHEMBL2013197)Show InChI InChI=1S/C18H19N3O/c22-16-9-8-15-17(14(16)12-21-10-4-5-11-21)20-18(19-15)13-6-2-1-3-7-13/h1-3,6-9,22H,4-5,10-12H2,(H,19,20) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline R&D
Curated by ChEMBL
| Assay Description Displacement of [3H]-Ro256981 from human NR2B receptor |
Bioorg Med Chem Lett 22: 2620-3 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.108 BindingDB Entry DOI: 10.7270/Q2KD1ZX3 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372871
(CHEMBL256011)Show SMILES Fc1ccc(cc1)C#Cc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:14| Show InChI InChI=1S/C26H17FN4O/c27-21-9-6-18(7-10-21)4-5-19-8-11-23-25(14-19)30-26(32)16-24(29-23)20-2-1-3-22(15-20)31-13-12-28-17-31/h1-3,6-15,17H,16H2,(H,30,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat recombinant mGluR2 expressed in CHO cells |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372871
(CHEMBL256011)Show SMILES Fc1ccc(cc1)C#Cc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:14| Show InChI InChI=1S/C26H17FN4O/c27-21-9-6-18(7-10-21)4-5-19-8-11-23-25(14-19)30-26(32)16-24(29-23)20-2-1-3-22(15-20)31-13-12-28-17-31/h1-3,6-15,17H,16H2,(H,30,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as effect on (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376482
(CHEMBL263649)Show SMILES CN(C)c1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-n1ccnc1 |c:6| Show InChI InChI=1S/C21H18F3N5O/c1-28(2)19-10-18-17(9-15(19)21(22,23)24)27-20(30)11-16(26-18)13-4-3-5-14(8-13)29-7-6-25-12-29/h3-10,12H,11H2,1-2H3,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50332986
(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-7-methyl-8-(tr...)Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-n1ccnn1 |c:4| Show InChI InChI=1S/C19H14F3N5O/c1-11-7-16-17(9-14(11)19(20,21)22)25-18(28)10-15(24-16)12-3-2-4-13(8-12)27-6-5-23-26-27/h2-9H,10H2,1H3,(H,25,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372880
(CHEMBL402886)Show SMILES O=C1CC(=Nc2ccc(cc2N1)C#Cc1ccccc1)c1cccc(c1)-n1ccnc1 |c:3| Show InChI InChI=1S/C26H18N4O/c31-26-17-24(21-7-4-8-22(16-21)30-14-13-27-18-30)28-23-12-11-20(15-25(23)29-26)10-9-19-5-2-1-3-6-19/h1-8,11-16,18H,17H2,(H,29,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as effect on (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376487
(CHEMBL261050)Show SMILES CCc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-n1ccnc1 |c:5| Show InChI InChI=1S/C21H17F3N4O/c1-2-13-9-18-19(10-16(13)21(22,23)24)27-20(29)11-17(26-18)14-4-3-5-15(8-14)28-7-6-25-12-28/h3-10,12H,2,11H2,1H3,(H,27,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50332990
(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)Show SMILES Oc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccc(F)cc1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C26H17FN4O2/c27-20-8-5-17(6-9-20)4-7-19-13-23-24(14-25(19)32)29-22(15-26(33)30-23)18-2-1-3-21(12-18)31-11-10-28-16-31/h1-3,5-6,8-14,16,32H,15H2,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as effect on (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376473
(CHEMBL260642)Show SMILES CC(C)CN(C)c1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-n1ccnn1 |c:9| Show InChI InChI=1S/C23H23F3N6O/c1-14(2)13-31(3)21-11-20-19(10-17(21)23(24,25)26)29-22(33)12-18(28-20)15-5-4-6-16(9-15)32-8-7-27-30-32/h4-11,14H,12-13H2,1-3H3,(H,29,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50332990
(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)Show SMILES Oc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccc(F)cc1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C26H17FN4O2/c27-20-8-5-17(6-9-20)4-7-19-13-23-24(14-25(19)32)29-22(15-26(33)30-23)18-2-1-3-21(12-18)31-11-10-28-16-31/h1-3,5-6,8-14,16,32H,15H2,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376467
(CHEMBL260636)Show SMILES Fc1ccccc1-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:12| Show InChI InChI=1S/C24H17FN4O/c25-20-7-2-1-6-19(20)16-8-9-21-23(13-16)28-24(30)14-22(27-21)17-4-3-5-18(12-17)29-11-10-26-15-29/h1-13,15H,14H2,(H,28,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 expressed in CHO cells assessed as inhibition of glutamta-induced GIRK current |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372881
(CHEMBL256812)Show SMILES Fc1ccc(cc1)C#Cc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnn1 |c:14| Show InChI InChI=1S/C25H16FN5O/c26-20-9-6-17(7-10-20)4-5-18-8-11-22-24(14-18)29-25(32)16-23(28-22)19-2-1-3-21(15-19)31-13-12-27-30-31/h1-3,6-15H,16H2,(H,29,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as effect on (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376467
(CHEMBL260636)Show SMILES Fc1ccccc1-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:12| Show InChI InChI=1S/C24H17FN4O/c25-20-7-2-1-6-19(20)16-8-9-21-23(13-16)28-24(30)14-22(27-21)17-4-3-5-18(12-17)29-11-10-26-15-29/h1-13,15H,14H2,(H,28,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50332992
(4-(3-(1H-imidazol-1-yl)phenyl)-7-methyl-8-(trifluo...)Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C20H15F3N4O/c1-12-7-17-18(9-15(12)20(21,22)23)26-19(28)10-16(25-17)13-3-2-4-14(8-13)27-6-5-24-11-27/h2-9,11H,10H2,1H3,(H,26,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Homo sapiens (Human)) | BDBM50379676
(CHEMBL2013204)Show InChI InChI=1S/C18H17F2N3O/c19-13-5-3-4-11(16(13)20)18-21-14-6-7-15(24)12(17(14)22-18)10-23-8-1-2-9-23/h3-7,24H,1-2,8-10H2,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline R&D
Curated by ChEMBL
| Assay Description Displacement of [3H]-Ro256981 from human NR2B receptor |
Bioorg Med Chem Lett 22: 2620-3 (2012)
Article DOI: 10.1016/j.bmcl.2012.01.108 BindingDB Entry DOI: 10.7270/Q2KD1ZX3 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372880
(CHEMBL402886)Show SMILES O=C1CC(=Nc2ccc(cc2N1)C#Cc1ccccc1)c1cccc(c1)-n1ccnc1 |c:3| Show InChI InChI=1S/C26H18N4O/c31-26-17-24(21-7-4-8-22(16-21)30-14-13-27-18-30)28-23-12-11-20(15-25(23)29-26)10-9-19-5-2-1-3-6-19/h1-8,11-16,18H,17H2,(H,29,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat recombinant mGluR2 expressed in CHO cells |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372869
(CHEMBL270616)Show SMILES O=C1CC(=Nc2cc(OCC#N)c(cc2N1)C#Cc1ccccc1)c1cccc(c1)-n1ccnc1 |c:3| Show InChI InChI=1S/C28H19N5O2/c29-11-14-35-27-17-26-25(16-22(27)10-9-20-5-2-1-3-6-20)32-28(34)18-24(31-26)21-7-4-8-23(15-21)33-13-12-30-19-33/h1-8,12-13,15-17,19H,14,18H2,(H,32,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as effect on (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376473
(CHEMBL260642)Show SMILES CC(C)CN(C)c1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-n1ccnn1 |c:9| Show InChI InChI=1S/C23H23F3N6O/c1-14(2)13-31(3)21-11-20-19(10-17(21)23(24,25)26)29-22(33)12-18(28-20)15-5-4-6-16(9-15)32-8-7-27-30-32/h4-11,14H,12-13H2,1-3H3,(H,29,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376481
(CHEMBL261051)Show SMILES FC(F)(F)c1cc2NC(=O)CC(=Nc2cc1Cl)c1cccc(c1)-n1ccnc1 |c:11| Show InChI InChI=1S/C19H12ClF3N4O/c20-14-8-17-16(7-13(14)19(21,22)23)26-18(28)9-15(25-17)11-2-1-3-12(6-11)27-5-4-24-10-27/h1-8,10H,9H2,(H,26,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372870
(CHEMBL404463)Show SMILES COCCOc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccccc1)c1cccc(c1)-n1ccnc1 |c:8| Show InChI InChI=1S/C29H24N4O3/c1-35-14-15-36-28-18-27-26(17-23(28)11-10-21-6-3-2-4-7-21)32-29(34)19-25(31-27)22-8-5-9-24(16-22)33-13-12-30-20-33/h2-9,12-13,16-18,20H,14-15,19H2,1H3,(H,32,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as effect on (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50332991
(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)Show SMILES Fc1ccccc1-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnn1 |c:12| Show InChI InChI=1S/C23H16FN5O/c24-19-7-2-1-6-18(19)15-8-9-20-22(13-15)27-23(30)14-21(26-20)16-4-3-5-17(12-16)29-11-10-25-28-29/h1-13H,14H2,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372867
(CHEMBL404080)Show SMILES Fc1ccccc1C#Cc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:14| Show InChI InChI=1S/C26H17FN4O/c27-22-7-2-1-4-19(22)10-8-18-9-11-23-25(14-18)30-26(32)16-24(29-23)20-5-3-6-21(15-20)31-13-12-28-17-31/h1-7,9,11-15,17H,16H2,(H,30,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as effect on (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376468
(CHEMBL259054)Show SMILES Fc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:12| Show InChI InChI=1S/C24H17FN4O/c25-19-7-4-16(5-8-19)17-6-9-21-23(13-17)28-24(30)14-22(27-21)18-2-1-3-20(12-18)29-11-10-26-15-29/h1-13,15H,14H2,(H,28,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372868
(CHEMBL404886)Show SMILES Oc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccc(F)cc1)c1cccc(c1)-n1ccnn1 |c:4| Show InChI InChI=1S/C25H16FN5O2/c26-19-8-5-16(6-9-19)4-7-18-13-22-23(14-24(18)32)28-21(15-25(33)29-22)17-2-1-3-20(12-17)31-11-10-27-30-31/h1-3,5-6,8-14,32H,15H2,(H,29,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as effect on (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376481
(CHEMBL261051)Show SMILES FC(F)(F)c1cc2NC(=O)CC(=Nc2cc1Cl)c1cccc(c1)-n1ccnc1 |c:11| Show InChI InChI=1S/C19H12ClF3N4O/c20-14-8-17-16(7-13(14)19(21,22)23)26-18(28)9-15(25-17)11-2-1-3-12(6-11)27-5-4-24-10-27/h1-8,10H,9H2,(H,26,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376479
(CHEMBL261081)Show SMILES Fc1ccc(F)c(c1)-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnn1 |c:13| Show InChI InChI=1S/C23H15F2N5O/c24-16-5-6-19(25)18(12-16)14-4-7-20-22(11-14)28-23(31)13-21(27-20)15-2-1-3-17(10-15)30-9-8-26-29-30/h1-12H,13H2,(H,28,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50225814
((E)-3-(4-oxo-7-(2-phenylethynyl)-4,5-dihydro-3H-be...)Show SMILES O=C1CC(=Nc2ccc(cc2N1)C#Cc1ccccc1)c1cccc(c1)C#N |c:3| Show InChI InChI=1S/C24H15N3O/c25-16-19-7-4-8-20(13-19)22-15-24(28)27-23-14-18(11-12-21(23)26-22)10-9-17-5-2-1-3-6-17/h1-8,11-14H,15H2,(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as effect on (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 3
(Rattus norvegicus (Rat)) | BDBM50376468
(CHEMBL259054)Show SMILES Fc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:12| Show InChI InChI=1S/C24H17FN4O/c25-19-7-4-16(5-8-19)17-6-9-21-23(13-17)28-24(30)14-22(27-21)18-2-1-3-20(12-18)29-11-10-26-15-29/h1-13,15H,14H2,(H,28,30) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR3 expressed in CHO cells assessed as inhibition of glutamate-induced GIRK current |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376466
(CHEMBL437835)Show SMILES Fc1ccc(F)c(c1)-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:13| Show InChI InChI=1S/C24H16F2N4O/c25-17-5-6-20(26)19(12-17)15-4-7-21-23(11-15)29-24(31)13-22(28-21)16-2-1-3-18(10-16)30-9-8-27-14-30/h1-12,14H,13H2,(H,29,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376479
(CHEMBL261081)Show SMILES Fc1ccc(F)c(c1)-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnn1 |c:13| Show InChI InChI=1S/C23H15F2N5O/c24-16-5-6-19(25)18(12-16)14-4-7-20-22(11-14)28-23(31)13-21(27-20)15-2-1-3-17(10-15)30-9-8-26-29-30/h1-12H,13H2,(H,28,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372869
(CHEMBL270616)Show SMILES O=C1CC(=Nc2cc(OCC#N)c(cc2N1)C#Cc1ccccc1)c1cccc(c1)-n1ccnc1 |c:3| Show InChI InChI=1S/C28H19N5O2/c29-11-14-35-27-17-26-25(16-22(27)10-9-20-5-2-1-3-6-20)32-28(34)18-24(31-26)21-7-4-8-23(15-21)33-13-12-30-19-33/h1-8,12-13,15-17,19H,14,18H2,(H,32,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat recombinant mGluR2 expressed in CHO cells |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50332992
(4-(3-(1H-imidazol-1-yl)phenyl)-7-methyl-8-(trifluo...)Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C20H15F3N4O/c1-12-7-17-18(9-15(12)20(21,22)23)26-19(28)10-16(25-17)13-3-2-4-14(8-13)27-6-5-24-11-27/h2-9,11H,10H2,1H3,(H,26,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376488
(CHEMBL261263)Show SMILES CC(C)CNc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-n1ccnc1 |c:8| Show InChI InChI=1S/C23H22F3N5O/c1-14(2)12-28-19-10-21-20(9-17(19)23(24,25)26)30-22(32)11-18(29-21)15-4-3-5-16(8-15)31-7-6-27-13-31/h3-10,13-14,28H,11-12H2,1-2H3,(H,30,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372868
(CHEMBL404886)Show SMILES Oc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccc(F)cc1)c1cccc(c1)-n1ccnn1 |c:4| Show InChI InChI=1S/C25H16FN5O2/c26-19-8-5-16(6-9-19)4-7-18-13-22-23(14-24(18)32)28-21(15-25(33)29-22)17-2-1-3-20(12-17)31-11-10-27-30-31/h1-3,5-6,8-14,32H,15H2,(H,29,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat recombinant mGluR2 expressed in CHO cells |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372867
(CHEMBL404080)Show SMILES Fc1ccccc1C#Cc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:14| Show InChI InChI=1S/C26H17FN4O/c27-22-7-2-1-4-19(22)10-8-18-9-11-23-25(14-18)30-26(32)16-24(29-23)20-5-3-6-21(15-20)31-13-12-28-17-31/h1-7,9,11-15,17H,16H2,(H,30,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat recombinant mGluR2 expressed in CHO cells |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376470
(CHEMBL405895)Show SMILES Oc1cc2N=C(CC(=O)Nc2cc1-c1ccccc1F)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C24H17FN4O2/c25-19-7-2-1-6-17(19)18-11-21-22(12-23(18)30)27-20(13-24(31)28-21)15-4-3-5-16(10-15)29-9-8-26-14-29/h1-12,14,30H,13H2,(H,28,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50332991
(4-(3-(1H-1,2,3-triazol-1-yl)phenyl)-8-(2-fluorophe...)Show SMILES Fc1ccccc1-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnn1 |c:12| Show InChI InChI=1S/C23H16FN5O/c24-19-7-2-1-6-18(19)15-8-9-20-22(13-15)27-23(30)14-21(26-20)16-4-3-5-17(12-16)29-11-10-25-28-29/h1-13H,14H2,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 expressed in CHO cells assessed as inhibition of glutamta-induced GIRK current |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50372870
(CHEMBL404463)Show SMILES COCCOc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccccc1)c1cccc(c1)-n1ccnc1 |c:8| Show InChI InChI=1S/C29H24N4O3/c1-35-14-15-36-28-18-27-26(17-23(28)11-10-21-6-3-2-4-7-21)32-29(34)19-25(31-27)22-8-5-9-24(16-22)33-13-12-30-20-33/h2-9,12-13,16-18,20H,14-15,19H2,1H3,(H,32,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat recombinant mGluR2 expressed in CHO cells |
Bioorg Med Chem Lett 18: 1091-5 (2008)
Article DOI: 10.1016/j.bmcl.2007.12.005 BindingDB Entry DOI: 10.7270/Q2VD7096 |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50332990
(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)Show SMILES Oc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccc(F)cc1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C26H17FN4O2/c27-20-8-5-17(6-9-20)4-7-19-13-23-24(14-25(19)32)29-22(15-26(33)30-23)18-2-1-3-21(12-18)31-11-10-28-16-31/h1-3,5-6,8-14,16,32H,15H2,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 expressed in CHO cells assessed as inhibition of glutamta-induced GIRK current |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376468
(CHEMBL259054)Show SMILES Fc1ccc(cc1)-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:12| Show InChI InChI=1S/C24H17FN4O/c25-19-7-4-16(5-8-19)17-6-9-21-23(13-17)28-24(30)14-22(27-21)18-2-1-3-20(12-18)29-11-10-26-15-29/h1-13,15H,14H2,(H,28,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Antagonist activity at rat mGluR2 assessed as blockade of (1S,3R)-ACPD-induced inhibition of forskolin-stimulated cAMP production |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50376485
(CHEMBL260415)Show SMILES Fc1cccc(c1)-c1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-n1ccnc1 |c:12| Show InChI InChI=1S/C24H17FN4O/c25-19-5-1-3-16(11-19)17-7-8-21-23(13-17)28-24(30)14-22(27-21)18-4-2-6-20(12-18)29-10-9-26-15-29/h1-13,15H,14H2,(H,28,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |
Metabotropic glutamate receptor 2
(Homo sapiens (Human)) | BDBM50332990
(4-(3-(1H-imidazol-1-yl)phenyl)-8-((4-fluorophenyl)...)Show SMILES Oc1cc2N=C(CC(=O)Nc2cc1C#Cc1ccc(F)cc1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C26H17FN4O2/c27-20-8-5-17(6-9-20)4-7-19-13-23-24(14-25(19)32)29-22(15-26(33)30-23)18-2-1-3-21(12-18)31-11-10-28-16-31/h1-3,5-6,8-14,16,32H,15H2,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]LY354740 from rat mGluR2 |
Bioorg Med Chem Lett 18: 2725-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D |
More data for this Ligand-Target Pair | |