Found 787 hits with Last Name = 'kiefer' and Initial = 'se' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50376226
(CHEMBL259922)Show SMILES Cc1ccc(cc1Nc1ncnc2n(ncc12)-c1ccccc1)C(=O)Nc1ccon1 Show InChI InChI=1S/C22H17N7O2/c1-14-7-8-15(22(30)27-19-9-10-31-28-19)11-18(14)26-20-17-12-25-29(21(17)24-13-23-20)16-5-3-2-4-6-16/h2-13H,1H3,(H,23,24,26)(H,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant p38alpha-mediated myelin basic protein phosphorylation |
Bioorg Med Chem Lett 18: 2652-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.019 BindingDB Entry DOI: 10.7270/Q2C53MR6 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50376226
(CHEMBL259922)Show SMILES Cc1ccc(cc1Nc1ncnc2n(ncc12)-c1ccccc1)C(=O)Nc1ccon1 Show InChI InChI=1S/C22H17N7O2/c1-14-7-8-15(22(30)27-19-9-10-31-28-19)11-18(14)26-20-17-12-25-29(21(17)24-13-23-20)16-5-3-2-4-6-16/h2-13H,1H3,(H,23,24,26)(H,27,28,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant p38alpha-mediated myelin basic protein phosphorylation |
Bioorg Med Chem Lett 18: 2652-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.019 BindingDB Entry DOI: 10.7270/Q2C53MR6 |
More data for this Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase gamma
(Homo sapiens (Human)) | BDBM50355636
(CHEMBL1403981)Show InChI InChI=1S/C12H8Cl2O2S2/c13-8-2-1-7(5-9(8)14)6-18-10-3-4-17-11(10)12(15)16/h1-5H,6H2,(H,15,16) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of RPTPgamma expressed in Escherichia coli BL21 (DE3) assessed as reduction in dephosphorylation of Z'-Lyte phospho-Tyr 1 peptide preincub... |
J Med Chem 54: 6548-62 (2011)
Article DOI: 10.1021/jm2003766 BindingDB Entry DOI: 10.7270/Q2862GTG |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50492385
(CHEMBL2401994)Show SMILES Cc1ccc(cc1NC(=O)c1ccc(s1)-c1ccc(cc1)C(=O)N1CCOCC1)C(=O)NC1CC1 Show InChI InChI=1S/C27H27N3O4S/c1-17-2-3-20(25(31)28-21-8-9-21)16-22(17)29-26(32)24-11-10-23(35-24)18-4-6-19(7-5-18)27(33)30-12-14-34-15-13-30/h2-7,10-11,16,21H,8-9,12-15H2,1H3,(H,28,31)(H,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha expressed in Escherichia coli using MBP as substrate preincubated for 10 mins prior to substrate addition measured after... |
Bioorg Med Chem Lett 23: 4120-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.047 BindingDB Entry DOI: 10.7270/Q2FN193N |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20655
(N-benzyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]a...)Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)NCc4ccccc4)c(C)c23)c1 Show InChI InChI=1S/C24H24N6O3/c1-15-9-10-18(23(31)29-33-3)11-20(15)28-22-21-16(2)19(13-30(21)27-14-26-22)24(32)25-12-17-7-5-4-6-8-17/h4-11,13-14H,12H2,1-3H3,(H,25,32)(H,29,31)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | 9.60 | n/a | n/a | 7.5 | 22 |
Novartis Pharmaceuticals
| Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i... |
J Med Chem 51: 4-16 (2008)
Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB |
More data for this Ligand-Target Pair | |
AP2-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50573689
(CHEMBL4857123)Show SMILES CC(C)C[C@H](N)COc1cc2n(C)c(=O)c3c(C)nccc3c2cc1C#N |r| | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of AAK1 (unknown origin) |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00472 BindingDB Entry DOI: 10.7270/Q2WQ07KF |
More data for this Ligand-Target Pair | |
AP2-associated protein kinase 1
(Homo sapiens (Human)) | BDBM50573689
(CHEMBL4857123)Show SMILES CC(C)C[C@H](N)COc1cc2n(C)c(=O)c3c(C)nccc3c2cc1C#N |r| | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01966 BindingDB Entry DOI: 10.7270/Q29P35QX |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 11/12/13/14
(Homo sapiens (Human)) | BDBM50492380
(CHEMBL2402001)Show SMILES Cc1ccc(cn1)-c1ccc(s1)C(=O)Nc1cc(ccc1C)C(=O)NC1CC1 Show InChI InChI=1S/C22H21N3O2S/c1-13-3-5-15(21(26)24-17-7-8-17)11-18(13)25-22(27)20-10-9-19(28-20)16-6-4-14(2)23-12-16/h3-6,9-12,17H,7-8H2,1-2H3,(H,24,26)(H,25,27) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.720 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of p38 MAPK-mediated TNFalpha production in LPS-induced human whole blood preincubated for 5 mins prior to LPS-treatment measured after 6 ... |
Bioorg Med Chem Lett 23: 4120-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.047 BindingDB Entry DOI: 10.7270/Q2FN193N |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50492384
(CHEMBL2401995)Show SMILES Cc1ccc(cc1NC(=O)c1ccc(s1)-c1ccc(cc1)C(=O)N1CCCCC1)C(=O)NC1CC1 Show InChI InChI=1S/C28H29N3O3S/c1-18-5-6-21(26(32)29-22-11-12-22)17-23(18)30-27(33)25-14-13-24(35-25)19-7-9-20(10-8-19)28(34)31-15-3-2-4-16-31/h5-10,13-14,17,22H,2-4,11-12,15-16H2,1H3,(H,29,32)(H,30,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha expressed in Escherichia coli using MBP as substrate preincubated for 10 mins prior to substrate addition measured after... |
Bioorg Med Chem Lett 23: 4120-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.047 BindingDB Entry DOI: 10.7270/Q2FN193N |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20645
(ethyl 4-{[5-(methoxycarbamoyl)-2-methylphenyl]amin...)Show SMILES CCOC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C Show InChI InChI=1S/C19H21N5O4/c1-5-28-19(26)14-9-24-16(12(14)3)17(20-10-21-24)22-15-8-13(7-6-11(15)2)18(25)23-27-4/h6-10H,5H2,1-4H3,(H,23,25)(H,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | 37 | n/a | n/a | 7.5 | 22 |
Novartis Pharmaceuticals
| Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i... |
J Med Chem 51: 4-16 (2008)
Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20650
(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)Show SMILES CCCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C Show InChI InChI=1S/C20H24N6O3/c1-5-8-21-20(28)15-10-26-17(13(15)3)18(22-11-23-26)24-16-9-14(7-6-12(16)2)19(27)25-29-4/h6-7,9-11H,5,8H2,1-4H3,(H,21,28)(H,25,27)(H,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.900 | n/a | 30 | n/a | n/a | 7.5 | 22 |
Novartis Pharmaceuticals
| Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i... |
J Med Chem 51: 4-16 (2008)
Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50544198
(CHEMBL4636136)Show SMILES CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NCCc1ccc(cc1)S(N)(=O)=O Show InChI InChI=1S/C24H26N6O3S2/c1-15(2)29-21-12-23(30-17-5-8-20-22(11-17)34-14-28-20)27-13-19(21)24(31)26-10-9-16-3-6-18(7-4-16)35(25,32)33/h3-8,11-15H,9-10H2,1-2H3,(H,26,31)(H2,25,32,33)(H2,27,29,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 (unknown origin) |
ACS Med Chem Lett 11: 1402-1409 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00082 BindingDB Entry DOI: 10.7270/Q2542S4M |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20640
(methyl 4-{[5-(methoxycarbamoyl)-2-methylphenyl]ami...)Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)OC)c(C)c23)c1 Show InChI InChI=1S/C18H19N5O4/c1-10-5-6-12(17(24)22-27-4)7-14(10)21-16-15-11(2)13(18(25)26-3)8-23(15)20-9-19-16/h5-9H,1-4H3,(H,22,24)(H,19,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | 160 | n/a | n/a | 7.5 | 22 |
Novartis Pharmaceuticals
| Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i... |
J Med Chem 51: 4-16 (2008)
Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20666
(propan-2-yl N-(4-{[5-(methoxycarbamoyl)-2-methylph...)Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(NC(=O)OC(C)C)c(C)c23)c1 Show InChI InChI=1S/C20H24N6O4/c1-11(2)30-20(28)24-16-9-26-17(13(16)4)18(21-10-22-26)23-15-8-14(7-6-12(15)3)19(27)25-29-5/h6-11H,1-5H3,(H,24,28)(H,25,27)(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | 110 | n/a | n/a | 7.5 | 22 |
Novartis Pharmaceuticals
| Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i... |
J Med Chem 51: 4-16 (2008)
Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20656
(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)NCc4ccccn4)c(C)c23)c1 Show InChI InChI=1S/C23H23N7O3/c1-14-7-8-16(22(31)29-33-3)10-19(14)28-21-20-15(2)18(12-30(20)27-13-26-21)23(32)25-11-17-6-4-5-9-24-17/h4-10,12-13H,11H2,1-3H3,(H,25,32)(H,29,31)(H,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | 2.40 | n/a | n/a | 7.5 | 22 |
Novartis Pharmaceuticals
| Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i... |
J Med Chem 51: 4-16 (2008)
Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20665
(ethyl N-(4-{[5-(methoxycarbamoyl)-2-methylphenyl]a...)Show SMILES CCOC(=O)Nc1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C Show InChI InChI=1S/C19H22N6O4/c1-5-29-19(27)23-15-9-25-16(12(15)3)17(20-10-21-25)22-14-8-13(7-6-11(14)2)18(26)24-28-4/h6-10H,5H2,1-4H3,(H,23,27)(H,24,26)(H,20,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | 26 | n/a | n/a | 7.5 | 22 |
Novartis Pharmaceuticals
| Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i... |
J Med Chem 51: 4-16 (2008)
Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 11
(Homo sapiens (Human)) | BDBM50236473
((R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)Show SMILES CC[C@@H](C)Nc1ncc(s1)C(=O)Nc1cc(ccc1C)C(=O)NC Show InChI InChI=1S/C17H22N4O2S/c1-5-11(3)20-17-19-9-14(24-17)16(23)21-13-8-12(15(22)18-4)7-6-10(13)2/h6-9,11H,5H2,1-4H3,(H,18,22)(H,19,20)(H,21,23)/t11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description Inhibition of human p38beta |
Bioorg Med Chem Lett 18: 1762-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.031 BindingDB Entry DOI: 10.7270/Q2057FNW |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50235904
(CHEMBL439238 | N-(R)-sec-butyl-6-(4-(2-fluoropheny...)Show SMILES CC[C@@H](C)Nc1nc2ccc(cc2s1)-c1[nH]cnc1-c1ccccc1F Show InChI InChI=1S/C20H19FN4S/c1-3-12(2)24-20-25-16-9-8-13(10-17(16)26-20)18-19(23-11-22-18)14-6-4-5-7-15(14)21/h4-12H,3H2,1-2H3,(H,22,23)(H,24,25)/t12-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of p38alpha |
Bioorg Med Chem Lett 18: 1874-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.011 BindingDB Entry DOI: 10.7270/Q2H41R5C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 11/12/13/14
(Homo sapiens (Human)) | BDBM50492375
(CHEMBL2401997)Show SMILES Cc1ccc(cc1NC(=O)c1ccc(s1)-c1cccnc1)C(=O)NC1CC1 Show InChI InChI=1S/C21H19N3O2S/c1-13-4-5-14(20(25)23-16-6-7-16)11-17(13)24-21(26)19-9-8-18(27-19)15-3-2-10-22-12-15/h2-5,8-12,16H,6-7H2,1H3,(H,23,25)(H,24,26) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of p38 MAPK-mediated TNFalpha production in LPS-induced human whole blood preincubated for 5 mins prior to LPS-treatment measured after 6 ... |
Bioorg Med Chem Lett 23: 4120-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.047 BindingDB Entry DOI: 10.7270/Q2FN193N |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50327416
(1-(2-(2-(2-(dimethylamino)ethylamino)-6-(2-(isopro...)Show SMILES CNC(=O)NCc1ccccc1-c1cc(nc(NCCN(C)C)n1)-c1cnc(NC(C)C)s1 Show InChI InChI=1S/C23H32N8OS/c1-15(2)28-23-27-14-20(33-23)19-12-18(29-21(30-19)25-10-11-31(4)5)17-9-7-6-8-16(17)13-26-22(32)24-3/h6-9,12,14-15H,10-11,13H2,1-5H3,(H,27,28)(H2,24,26,32)(H,25,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of bacterially expressed activated p38alpha pre-incubated 10 mins measured after 45 mins by scintillation counting |
Bioorg Med Chem Lett 20: 5864-8 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.102 BindingDB Entry DOI: 10.7270/Q22F7NP6 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50331633
(5-amino-1-butyl-N-(5-(isoxazol-3-ylcarbamoyl)-2-me...)Show SMILES CCCCn1ncc(C(=O)Nc2cc(ccc2C)C(=O)Nc2ccon2)c1N Show InChI InChI=1S/C19H22N6O3/c1-3-4-8-25-17(20)14(11-21-25)19(27)22-15-10-13(6-5-12(15)2)18(26)23-16-7-9-28-24-16/h5-7,9-11H,3-4,8,20H2,1-2H3,(H,22,27)(H,23,24,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant p38alpha |
Bioorg Med Chem Lett 20: 6886-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.034 BindingDB Entry DOI: 10.7270/Q2BP0319 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50331631
(5-amino-1-(4-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)Show SMILES Cc1ccc(cc1NC(=O)c1cnn(c1N)-c1ccc(F)cc1)C(=O)Nc1ccon1 Show InChI InChI=1S/C21H17FN6O3/c1-12-2-3-13(20(29)26-18-8-9-31-27-18)10-17(12)25-21(30)16-11-24-28(19(16)23)15-6-4-14(22)5-7-15/h2-11H,23H2,1H3,(H,25,30)(H,26,27,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant p38alpha |
Bioorg Med Chem Lett 20: 6886-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.034 BindingDB Entry DOI: 10.7270/Q2BP0319 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50331630
(5-amino-N-(5-(1-ethyl-1H-pyrazol-5-ylcarbamoyl)-2-...)Show SMILES CCn1nccc1NC(=O)c1ccc(C)c(NC(=O)c2cnn(c2N)-c2ccc(F)cc2)c1 Show InChI InChI=1S/C23H22FN7O2/c1-3-30-20(10-11-26-30)29-22(32)15-5-4-14(2)19(12-15)28-23(33)18-13-27-31(21(18)25)17-8-6-16(24)7-9-17/h4-13H,3,25H2,1-2H3,(H,28,33)(H,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant p38alpha |
Bioorg Med Chem Lett 20: 6886-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.034 BindingDB Entry DOI: 10.7270/Q2BP0319 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50331629
(5-amino-1-(2-fluorophenyl)-N-(5-(isoxazol-3-ylcarb...)Show SMILES Cc1ccc(cc1NC(=O)c1cnn(c1N)-c1ccccc1F)C(=O)Nc1ccon1 Show InChI InChI=1S/C21H17FN6O3/c1-12-6-7-13(20(29)26-18-8-9-31-27-18)10-16(12)25-21(30)14-11-24-28(19(14)23)17-5-3-2-4-15(17)22/h2-11H,23H2,1H3,(H,25,30)(H,26,27,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant p38alpha |
Bioorg Med Chem Lett 20: 6886-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.034 BindingDB Entry DOI: 10.7270/Q2BP0319 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50331626
(5-amino-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphen...)Show SMILES Cc1ccc(cc1NC(=O)c1cnn(c1N)-c1ccccn1)C(=O)Nc1ccon1 Show InChI InChI=1S/C20H17N7O3/c1-12-5-6-13(19(28)25-16-7-9-30-26-16)10-15(12)24-20(29)14-11-23-27(18(14)21)17-4-2-3-8-22-17/h2-11H,21H2,1H3,(H,24,29)(H,25,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant p38alpha |
Bioorg Med Chem Lett 20: 6886-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.034 BindingDB Entry DOI: 10.7270/Q2BP0319 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50492382
(CHEMBL2401981)Show SMILES Cc1ccc(cc1NC(=O)c1ccc(s1)-c1ccc(Cl)cc1)C(=O)NC1CC1 Show InChI InChI=1S/C22H19ClN2O2S/c1-13-2-3-15(21(26)24-17-8-9-17)12-18(13)25-22(27)20-11-10-19(28-20)14-4-6-16(23)7-5-14/h2-7,10-12,17H,8-9H2,1H3,(H,24,26)(H,25,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha expressed in Escherichia coli using MBP as substrate preincubated for 10 mins prior to substrate addition measured after... |
Bioorg Med Chem Lett 23: 4120-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.047 BindingDB Entry DOI: 10.7270/Q2FN193N |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 11
(Homo sapiens (Human)) | BDBM50236473
((R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)Show SMILES CC[C@@H](C)Nc1ncc(s1)C(=O)Nc1cc(ccc1C)C(=O)NC Show InChI InChI=1S/C17H22N4O2S/c1-5-11(3)20-17-19-9-14(24-17)16(23)21-13-8-12(15(22)18-4)7-6-10(13)2/h6-9,11H,5H2,1-4H3,(H,18,22)(H,19,20)(H,21,23)/t11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of p38beta (unknown origin) |
Bioorg Med Chem Lett 23: 4120-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.047 BindingDB Entry DOI: 10.7270/Q2FN193N |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50236476
(CHEMBL255482 | N-(5-(ethylcarbamoyl)-2-methylpheny...)Show InChI InChI=1S/C17H22N4O2S/c1-4-8-19-17-20-10-14(24-17)16(23)21-13-9-12(7-6-11(13)3)15(22)18-5-2/h6-7,9-10H,4-5,8H2,1-3H3,(H,18,22)(H,19,20)(H,21,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha |
Bioorg Med Chem Lett 18: 1762-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.031 BindingDB Entry DOI: 10.7270/Q2057FNW |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 11
(Homo sapiens (Human)) | BDBM50236473
((R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)Show SMILES CC[C@@H](C)Nc1ncc(s1)C(=O)Nc1cc(ccc1C)C(=O)NC Show InChI InChI=1S/C17H22N4O2S/c1-5-11(3)20-17-19-9-14(24-17)16(23)21-13-8-12(15(22)18-4)7-6-10(13)2/h6-9,11H,5H2,1-4H3,(H,18,22)(H,19,20)(H,21,23)/t11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human p38beta expressed in Escherichia coli using MBP as substrate preincubated for 10 mins prior to substrate addition measured after ... |
Bioorg Med Chem Lett 23: 4120-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.047 BindingDB Entry DOI: 10.7270/Q2FN193N |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20657
(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)N[C@@H](C)c4ccccc4)c(C)c23)c1 |r| Show InChI InChI=1S/C25H26N6O3/c1-15-10-11-19(24(32)30-34-4)12-21(15)29-23-22-16(2)20(13-31(22)27-14-26-23)25(33)28-17(3)18-8-6-5-7-9-18/h5-14,17H,1-4H3,(H,28,33)(H,30,32)(H,26,27,29)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 2.20 | n/a | 10 | n/a | n/a | 7.5 | 22 |
Novartis Pharmaceuticals
| Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i... |
J Med Chem 51: 4-16 (2008)
Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20653
(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-N-(...)Show SMILES COCCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C Show InChI InChI=1S/C20H24N6O4/c1-12-5-6-14(19(27)25-30-4)9-16(12)24-18-17-13(2)15(10-26(17)23-11-22-18)20(28)21-7-8-29-3/h5-6,9-11H,7-8H2,1-4H3,(H,21,28)(H,25,27)(H,22,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20 | n/a | 140 | n/a | n/a | 7.5 | 22 |
Novartis Pharmaceuticals
| Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i... |
J Med Chem 51: 4-16 (2008)
Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20657
(4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-m...)Show SMILES CONC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)N[C@@H](C)c4ccccc4)c(C)c23)c1 |r| Show InChI InChI=1S/C25H26N6O3/c1-15-10-11-19(24(32)30-34-4)12-21(15)29-23-22-16(2)20(13-31(22)27-14-26-23)25(33)28-17(3)18-8-6-5-7-9-18/h5-14,17H,1-4H3,(H,28,33)(H,30,32)(H,26,27,29)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| MMDB PC cid PC sid PDB UniChem
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 mins |
J Med Chem 53: 6629-39 (2010)
Article DOI: 10.1021/jm100540x BindingDB Entry DOI: 10.7270/Q2JM29T1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50236483
((S)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbam...)Show SMILES CC[C@H](C)Nc1ncc(s1)C(=O)Nc1cc(ccc1C)C(=O)NC Show InChI InChI=1S/C17H22N4O2S/c1-5-11(3)20-17-19-9-14(24-17)16(23)21-13-8-12(15(22)18-4)7-6-10(13)2/h6-9,11H,5H2,1-4H3,(H,18,22)(H,19,20)(H,21,23)/t11-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha |
Bioorg Med Chem Lett 18: 1762-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.031 BindingDB Entry DOI: 10.7270/Q2057FNW |
More data for this Ligand-Target Pair | |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM207906
(US9546153, ex. 42)Show SMILES CC(C)(O)[C@H](F)CNC(=O)c1cnc(Nc2ccc3ncsc3c2)cc1NC1CC1 |r| Show InChI InChI=1S/C21H24FN5O2S/c1-21(2,29)18(22)10-24-20(28)14-9-23-19(8-16(14)26-12-3-4-12)27-13-5-6-15-17(7-13)30-11-25-15/h5-9,11-12,18,29H,3-4,10H2,1-2H3,(H,24,28)(H2,23,26,27)/t18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
| Assay Description Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assay |
ACS Med Chem Lett 11: 1402-1409 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00082 BindingDB Entry DOI: 10.7270/Q2542S4M |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM207860
(US9546153, ex. 35)Show SMILES CC(C)Nc1cc(Nc2ccc3ncsc3c2)ncc1C(=O)NC[C@@H](F)C(C)(C)O |r| Show InChI InChI=1S/C21H26FN5O2S/c1-12(2)26-16-8-19(27-13-5-6-15-17(7-13)30-11-25-15)23-9-14(16)20(28)24-10-18(22)21(3,4)29/h5-9,11-12,18,29H,10H2,1-4H3,(H,24,28)(H2,23,26,27)/t18-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
| Assay Description Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assay |
ACS Med Chem Lett 11: 1402-1409 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00082 BindingDB Entry DOI: 10.7270/Q2542S4M |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50235905
(CHEMBL255469 | N-(S)-sec-butyl-6-(4-(2-fluoropheny...)Show SMILES CC[C@H](C)Nc1nc2ccc(cc2s1)-c1[nH]cnc1-c1ccccc1F Show InChI InChI=1S/C20H19FN4S/c1-3-12(2)24-20-25-16-9-8-13(10-17(16)26-20)18-19(23-11-22-18)14-6-4-5-7-15(14)21/h4-12H,3H2,1-2H3,(H,22,23)(H,24,25)/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of p38alpha |
Bioorg Med Chem Lett 18: 1874-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.011 BindingDB Entry DOI: 10.7270/Q2H41R5C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50492376
(CHEMBL2402000)Show SMILES Cc1ccc(cc1NC(=O)c1ccc(s1)-c1cnccc1N1CCOCC1)C(=O)NC1CC1 Show InChI InChI=1S/C25H26N4O3S/c1-16-2-3-17(24(30)27-18-4-5-18)14-20(16)28-25(31)23-7-6-22(33-23)19-15-26-9-8-21(19)29-10-12-32-13-11-29/h2-3,6-9,14-15,18H,4-5,10-13H2,1H3,(H,27,30)(H,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha expressed in Escherichia coli using MBP as substrate preincubated for 10 mins prior to substrate addition measured after... |
Bioorg Med Chem Lett 23: 4120-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.05.047 BindingDB Entry DOI: 10.7270/Q2FN193N |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50348883
(CHEMBL1807447)Show SMILES Cc1c(cn2ncnc(Nc3cc(ccc3C)C(=O)Nc3ccon3)c12)C(=O)c1ccccc1 Show InChI InChI=1S/C25H20N6O3/c1-15-8-9-18(25(33)29-21-10-11-34-30-21)12-20(15)28-24-22-16(2)19(13-31(22)27-14-26-24)23(32)17-6-4-3-5-7-17/h3-14H,1-2H3,(H,26,27,28)(H,29,30,33) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description Inhibition of human cloned GST-fused p38alpha expressed in Escherichia coli using myelin basic protein as substrate after 45 mins |
Bioorg Med Chem Lett 21: 4633-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.091 BindingDB Entry DOI: 10.7270/Q2WS8TMN |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50376228
(CHEMBL261021)Show SMILES CNC(=O)c1ccc(C)c(Nc2nc(N)nc3n(ncc23)-c2ccccc2)c1 Show InChI InChI=1S/C20H19N7O/c1-12-8-9-13(19(28)22-2)10-16(12)24-17-15-11-23-27(14-6-4-3-5-7-14)18(15)26-20(21)25-17/h3-11H,1-2H3,(H,22,28)(H3,21,24,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant p38alpha-mediated myelin basic protein phosphorylation |
Bioorg Med Chem Lett 18: 2652-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.019 BindingDB Entry DOI: 10.7270/Q2C53MR6 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20652
(N-[(2S)-butan-2-yl]-4-{[5-(methoxycarbamoyl)-2-met...)Show SMILES CC[C@H](C)NC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C |r| Show InChI InChI=1S/C21H26N6O3/c1-6-13(3)24-21(29)16-10-27-18(14(16)4)19(22-11-23-27)25-17-9-15(8-7-12(17)2)20(28)26-30-5/h7-11,13H,6H2,1-5H3,(H,24,29)(H,26,28)(H,22,23,25)/t13-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | <2 | n/a | n/a | 7.5 | 22 |
Novartis Pharmaceuticals
| Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i... |
J Med Chem 51: 4-16 (2008)
Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50331627
(5-amino-N-(5-(1-ethyl-1H-pyrazol-5-ylcarbamoyl)-2-...)Show SMILES CCn1nccc1NC(=O)c1ccc(C)c(NC(=O)c2cnn(c2N)-c2ccccc2F)c1 Show InChI InChI=1S/C23H22FN7O2/c1-3-30-20(10-11-26-30)29-22(32)15-9-8-14(2)18(12-15)28-23(33)16-13-27-31(21(16)25)19-7-5-4-6-17(19)24/h4-13H,3,25H2,1-2H3,(H,28,33)(H,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant p38alpha |
Bioorg Med Chem Lett 20: 6886-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.034 BindingDB Entry DOI: 10.7270/Q2BP0319 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50348884
(CHEMBL1807448)Show SMILES COC(=O)NC(=O)c1ccc(C)c(Nc2ncnn3cc(C(=O)c4ccccc4)c(C)c23)c1 Show InChI InChI=1S/C24H21N5O4/c1-14-9-10-17(23(31)28-24(32)33-3)11-19(14)27-22-20-15(2)18(12-29(20)26-13-25-22)21(30)16-7-5-4-6-8-16/h4-13H,1-3H3,(H,25,26,27)(H,28,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description Inhibition of human cloned GST-fused p38alpha expressed in Escherichia coli using myelin basic protein as substrate after 45 mins |
Bioorg Med Chem Lett 21: 4633-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.091 BindingDB Entry DOI: 10.7270/Q2WS8TMN |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50331625
(5-amino-N-(5-(isoxazol-3-ylcarbamoyl)-2-methylphen...)Show SMILES Cc1ccc(cc1NC(=O)c1cnn(c1N)-c1ccccc1)C(=O)Nc1ccon1 Show InChI InChI=1S/C21H18N6O3/c1-13-7-8-14(20(28)25-18-9-10-30-26-18)11-17(13)24-21(29)16-12-23-27(19(16)22)15-5-3-2-4-6-15/h2-12H,22H2,1H3,(H,24,29)(H,25,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| MMDB PDB Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant p38alpha |
Bioorg Med Chem Lett 20: 6886-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.10.034 BindingDB Entry DOI: 10.7270/Q2BP0319 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50376230
(CHEMBL410136)Show SMILES Cc1ccc(cc1Nc1ncnc2n(ncc12)-c1ccccc1)C(=O)Nc1ccn[nH]1 Show InChI InChI=1S/C22H18N8O/c1-14-7-8-15(22(31)28-19-9-10-25-29-19)11-18(14)27-20-17-12-26-30(21(17)24-13-23-20)16-5-3-2-4-6-16/h2-13H,1H3,(H,23,24,27)(H2,25,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant p38alpha-mediated myelin basic protein phosphorylation |
Bioorg Med Chem Lett 18: 2652-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.019 BindingDB Entry DOI: 10.7270/Q2C53MR6 |
More data for this Ligand-Target Pair | |
LIM domain kinase 2
(Homo sapiens (Human)) | BDBM50327391
(CHEMBL1258976 | N1-(4-(2-chlorophenyl)-6-(2-(isopr...)Show SMILES CC(C)Nc1ncc(s1)-c1cc(nc(NCCN(C)C)n1)-c1ccccc1Cl Show InChI InChI=1S/C20H25ClN6S/c1-13(2)24-20-23-12-18(28-20)17-11-16(14-7-5-6-8-15(14)21)25-19(26-17)22-9-10-27(3)4/h5-8,11-13H,9-10H2,1-4H3,(H,23,24)(H,22,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.05 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Inhibition of LIMK2 |
Bioorg Med Chem Lett 20: 5864-8 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.102 BindingDB Entry DOI: 10.7270/Q22F7NP6 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20649
(N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]am...)Show SMILES CCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C Show InChI InChI=1S/C19H22N6O3/c1-5-20-19(27)14-9-25-16(12(14)3)17(21-10-22-25)23-15-8-13(7-6-11(15)2)18(26)24-28-4/h6-10H,5H2,1-4H3,(H,20,27)(H,24,26)(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 3.10 | n/a | 61 | n/a | n/a | 7.5 | 22 |
Novartis Pharmaceuticals
| Assay Description The kinase activity was determined by quantitation of the amount of radioactive phosphate transferred to myelin basic protein (MBP) with or without i... |
J Med Chem 51: 4-16 (2008)
Article DOI: 10.1021/jm7009414 BindingDB Entry DOI: 10.7270/Q23T9FHB |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM20649
(N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]am...)Show SMILES CCNC(=O)c1cn2ncnc(Nc3cc(ccc3C)C(=O)NOC)c2c1C Show InChI InChI=1S/C19H22N6O3/c1-5-20-19(27)14-9-25-16(12(14)3)17(21-10-22-25)23-15-8-13(7-6-11(15)2)18(26)24-28-4/h6-10H,5H2,1-4H3,(H,20,27)(H,24,26)(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| DrugBank MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank MMDB PDB Article PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of bacterially expressed p38alpha pretreated for 10 mins measured after 45 mins |
J Med Chem 53: 6629-39 (2010)
Article DOI: 10.1021/jm100540x BindingDB Entry DOI: 10.7270/Q2JM29T1 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Interleukin-1 receptor-associated kinase 4
(Homo sapiens (Human)) | BDBM50544205
(CHEMBL4641090)Show SMILES CC(C)Nc1cc(Nc2ccn3nccc3n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O |r| Show InChI InChI=1S/C20H26FN7O2/c1-12(2)25-14-9-17(26-16-6-8-28-18(27-16)5-7-24-28)22-10-13(14)19(29)23-11-15(21)20(3,4)30/h5-10,12,15,30H,11H2,1-4H3,(H,23,29)(H2,22,25,26,27)/t15-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
| Assay Description Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assay |
ACS Med Chem Lett 11: 1402-1409 (2020)
Article DOI: 10.1021/acsmedchemlett.0c00082 BindingDB Entry DOI: 10.7270/Q2542S4M |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50235895
(6-(5-amino-3-(2-fluorophenyl)-1H-pyrazol-4-yl)-N-(...)Show SMILES CC[C@@H](C)Nc1nc2ccc(cc2s1)-c1c(N)[nH]nc1-c1ccccc1F Show InChI InChI=1S/C20H20FN5S/c1-3-11(2)23-20-24-15-9-8-12(10-16(15)27-20)17-18(25-26-19(17)22)13-6-4-5-7-14(13)21/h4-11H,3H2,1-2H3,(H,23,24)(H3,22,25,26)/t11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description Inhibition of p38alpha |
Bioorg Med Chem Lett 18: 1874-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.011 BindingDB Entry DOI: 10.7270/Q2H41R5C |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50236490
(CHEMBL257995 | N-(5-carbamoyl-2-methylphenyl)-2-(i...)Show InChI InChI=1S/C15H18N4O2S/c1-8(2)18-15-17-7-12(22-15)14(21)19-11-6-10(13(16)20)5-4-9(11)3/h4-8H,1-3H3,(H2,16,20)(H,17,18)(H,19,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha |
Bioorg Med Chem Lett 18: 1762-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.02.031 BindingDB Entry DOI: 10.7270/Q2057FNW |
More data for this Ligand-Target Pair | |