Found 111 hits with Last Name = 'kilroy' and Initial = 'c' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182352
(2-(5-(3-chloro-4-(furan-2-yl)phenyl)-3-(difluorome...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(Cl)c1)C(F)F Show InChI InChI=1S/C20H14ClF2N3O3S/c1-30(27,28)13-5-7-19(24-11-13)26-17(10-16(25-26)20(22)23)12-4-6-14(15(21)9-12)18-3-2-8-29-18/h2-11,20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182338
(2-(5-(4-(furan-2-yl)-3-methylphenyl)-3-(trifluorom...)Show SMILES Cc1cc(ccc1-c1ccco1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C21H16F3N3O3S/c1-13-10-14(5-7-16(13)18-4-3-9-30-18)17-11-19(21(22,23)24)26-27(17)20-8-6-15(12-25-20)31(2,28)29/h3-12H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182347
(2-(5-(3-chloro-4-(furan-2-yl)phenyl)-3-(trifluorom...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(Cl)c1)C(F)(F)F Show InChI InChI=1S/C20H13ClF3N3O3S/c1-31(28,29)13-5-7-19(25-11-13)27-16(10-18(26-27)20(22,23)24)12-4-6-14(15(21)9-12)17-3-2-8-30-17/h2-11H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182339
(2-(furan-2-yl)-5-(1-(5-(methylsulfonyl)pyridin-2-y...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(c1)C#N)C(F)(F)F Show InChI InChI=1S/C21H13F3N4O3S/c1-32(29,30)15-5-7-20(26-12-15)28-17(10-19(27-28)21(22,23)24)13-4-6-16(14(9-13)11-25)18-3-2-8-31-18/h2-10,12H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182353
(2-(3-(difluoromethyl)-5-(3-methyl-4-(thiazol-4-yl)...)Show SMILES Cc1cc(ccc1-c1cscn1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C20H16F2N4O2S2/c1-12-7-13(3-5-15(12)17-10-29-11-24-17)18-8-16(20(21)22)25-26(18)19-6-4-14(9-23-19)30(2,27)28/h3-11,20H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182332
(2-(5-(4-(furan-2-yl)phenyl)-3-(trifluoromethyl)-1H...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(cc1)-c1ccco1)C(F)(F)F Show InChI InChI=1S/C20H14F3N3O3S/c1-30(27,28)15-8-9-19(24-12-15)26-16(11-18(25-26)20(21,22)23)13-4-6-14(7-5-13)17-3-2-10-29-17/h2-12H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182345
(2-(5-(3-methyl-4-(oxazol-4-yl)phenyl)-3-(trifluoro...)Show SMILES Cc1cc(ccc1-c1cocn1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C20H15F3N4O3S/c1-12-7-13(3-5-15(12)16-10-30-11-25-16)17-8-18(20(21,22)23)26-27(17)19-6-4-14(9-24-19)31(2,28)29/h3-11H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137423
(2-(4-Chloro-3-difluoromethyl-5-phenyl-pyrazol-1-yl...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(C(F)F)c(Cl)c1-c1ccccc1 Show InChI InChI=1S/C16H12ClF2N3O2S/c1-25(23,24)11-7-8-12(20-9-11)22-15(10-5-3-2-4-6-10)13(17)14(21-22)16(18)19/h2-9,16H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137438
(5-Methanesulfonyl-2-[5-(4-methoxy-phenyl)-3-triflu...)Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O3S/c1-26-12-5-3-11(4-6-12)14-9-15(17(18,19)20)22-23(14)16-8-7-13(10-21-16)27(2,24)25/h3-10H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182335
(2-(5-(3-fluoro-4-(furan-2-yl)phenyl)-3-(trifluorom...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(F)c1)C(F)(F)F Show InChI InChI=1S/C20H13F4N3O3S/c1-31(28,29)13-5-7-19(25-11-13)27-16(10-18(26-27)20(22,23)24)12-4-6-14(15(21)9-12)17-3-2-8-30-17/h2-11H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137442
(2-[3-Difluoromethyl-5-(3-fluoro-4-methoxy-phenyl)-...)Show SMILES COc1ccc(cc1F)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C17H14F3N3O3S/c1-26-15-5-3-10(7-12(15)18)14-8-13(17(19)20)22-23(14)16-6-4-11(9-21-16)27(2,24)25/h3-9,17H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182351
(2-(5-(3-chloro-4-(thiazol-4-yl)phenyl)-3-(trifluor...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2cscn2)c(Cl)c1)C(F)(F)F Show InChI InChI=1S/C19H12ClF3N4O2S2/c1-31(28,29)12-3-5-18(24-8-12)27-16(7-17(26-27)19(21,22)23)11-2-4-13(14(20)6-11)15-9-30-10-25-15/h2-10H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | <50 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Canis familiaris) | BDBM50137420
(2-[5-(4-Ethoxy-phenyl)-3-trifluoromethyl-pyrazol-1...)Show SMILES CCOc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C18H16F3N3O3S/c1-3-27-13-6-4-12(5-7-13)15-10-16(18(19,20)21)23-24(15)17-9-8-14(11-22-17)28(2,25)26/h4-11H,3H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137435
(2-(4-Chloro-5-phenyl-3-trifluoromethyl-pyrazol-1-y...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(c(Cl)c1-c1ccccc1)C(F)(F)F Show InChI InChI=1S/C16H11ClF3N3O2S/c1-26(24,25)11-7-8-12(21-9-11)23-14(10-5-3-2-4-6-10)13(17)15(22-23)16(18,19)20/h2-9H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182334
(2-(3-(difluoromethyl)-5-(3-fluoro-4-(furan-2-yl)ph...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(F)c1)C(F)F Show InChI InChI=1S/C20H14F3N3O3S/c1-30(27,28)13-5-7-19(24-11-13)26-17(10-16(25-26)20(22)23)12-4-6-14(15(21)9-12)18-3-2-8-29-18/h2-11,20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137439
(2-[5-(2-Fluoro-4-methoxy-phenyl)-3-trifluoromethyl...)Show SMILES COc1ccc(-c2cc(nn2-c2ccc(cn2)S(C)(=O)=O)C(F)(F)F)c(F)c1 Show InChI InChI=1S/C17H13F4N3O3S/c1-27-10-3-5-12(13(18)7-10)14-8-15(17(19,20)21)23-24(14)16-6-4-11(9-22-16)28(2,25)26/h3-9H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137424
(2-[4-Chloro-5-(3-chloro-4-methoxy-phenyl)-3-difluo...)Show SMILES COc1ccc(cc1Cl)-c1c(Cl)c(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C17H13Cl2F2N3O3S/c1-27-12-5-3-9(7-11(12)18)16-14(19)15(17(20)21)23-24(16)13-6-4-10(8-22-13)28(2,25)26/h3-8,17H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137411
(2-[3-Difluoromethyl-5-(4-methoxy-phenyl)-pyrazol-1...)Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C17H15F2N3O3S/c1-25-12-5-3-11(4-6-12)15-9-14(17(18)19)21-22(15)16-8-7-13(10-20-16)26(2,23)24/h3-10,17H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182346
(2-(5-(3-methyl-4-(oxazol-2-yl)phenyl)-3-(trifluoro...)Show SMILES Cc1cc(ccc1-c1ncco1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C20H15F3N4O3S/c1-12-9-13(3-5-15(12)19-24-7-8-30-19)16-10-17(20(21,22)23)26-27(16)18-6-4-14(11-25-18)31(2,28)29/h3-11H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137437
(5-Methanesulfonyl-2-[5-(4-methylsulfanyl-phenyl)-3...)Show SMILES CSc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S2/c1-26-12-5-3-11(4-6-12)14-9-15(17(18,19)20)22-23(14)16-8-7-13(10-21-16)27(2,24)25/h3-10H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137427
(2-(4-Bromo-3-difluoromethyl-5-phenyl-pyrazol-1-yl)...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(C(F)F)c(Br)c1-c1ccccc1 Show InChI InChI=1S/C16H12BrF2N3O2S/c1-25(23,24)11-7-8-12(20-9-11)22-15(10-5-3-2-4-6-10)13(17)14(21-22)16(18)19/h2-9,16H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182333
(2-(5-(3-methyl-4-(thiazol-4-yl)phenyl)-3-(trifluor...)Show SMILES Cc1cc(ccc1-c1cscn1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C20H15F3N4O2S2/c1-12-7-13(3-5-15(12)16-10-30-11-25-16)17-8-18(20(21,22)23)26-27(17)19-6-4-14(9-24-19)31(2,28)29/h3-11H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182340
(5-(1-(5-(methylsulfonyl)pyridin-2-yl)-3-(trifluoro...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2nccs2)c(c1)C#N)C(F)(F)F Show InChI InChI=1S/C20H12F3N5O2S2/c1-32(29,30)14-3-5-18(26-11-14)28-16(9-17(27-28)20(21,22)23)12-2-4-15(13(8-12)10-24)19-25-6-7-31-19/h2-9,11H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137414
(2-[5-(4-Chloro-phenyl)-3-difluoromethyl-pyrazol-1-...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Cl)cc1)C(F)F Show InChI InChI=1S/C16H12ClF2N3O2S/c1-25(23,24)12-6-7-15(20-9-12)22-14(8-13(21-22)16(18)19)10-2-4-11(17)5-3-10/h2-9,16H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137428
(2-[3-Difluoromethyl-5-(4-methylsulfanyl-phenyl)-py...)Show SMILES CSc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C17H15F2N3O2S2/c1-25-12-5-3-11(4-6-12)15-9-14(17(18)19)21-22(15)16-8-7-13(10-20-16)26(2,23)24/h3-10,17H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137440
(CHEMBL176934 | {4-[2-(5-Methanesulfonyl-pyridin-2-...)Show SMILES CN(C)c1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C18H17F3N4O2S/c1-24(2)13-6-4-12(5-7-13)15-10-16(18(19,20)21)23-25(15)17-9-8-14(11-22-17)28(3,26)27/h4-11H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137420
(2-[5-(4-Ethoxy-phenyl)-3-trifluoromethyl-pyrazol-1...)Show SMILES CCOc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C18H16F3N3O3S/c1-3-27-13-6-4-12(5-7-13)15-10-16(18(19,20)21)23-24(15)17-9-8-14(11-22-17)28(2,25)26/h4-11H,3H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182343
(2-(3-(difluoromethyl)-5-(4-(furan-2-yl)phenyl)-1H-...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(cc1)-c1ccco1)C(F)F Show InChI InChI=1S/C20H15F2N3O3S/c1-29(26,27)15-8-9-19(23-12-15)25-17(11-16(24-25)20(21)22)13-4-6-14(7-5-13)18-3-2-10-28-18/h2-12,20H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182342
(5-(methylsulfonyl)-2-(5-(4-(thiazol-4-yl)phenyl)-3...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(cc1)-c1cscn1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O2S2/c1-30(27,28)14-6-7-18(23-9-14)26-16(8-17(25-26)19(20,21)22)13-4-2-12(3-5-13)15-10-29-11-24-15/h2-11H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137412
(5-Methanesulfonyl-2-(4-methyl-5-phenyl-3-trifluoro...)Show SMILES Cc1c(nn(c1-c1ccccc1)-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H14F3N3O2S/c1-11-15(12-6-4-3-5-7-12)23(22-16(11)17(18,19)20)14-9-8-13(10-21-14)26(2,24)25/h3-10H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137434
(2-[3-Difluoromethyl-5-(4-methoxy-3-methyl-phenyl)-...)Show SMILES COc1ccc(cc1C)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C18H17F2N3O3S/c1-11-8-12(4-6-16(11)26-2)15-9-14(18(19)20)22-23(15)17-7-5-13(10-21-17)27(3,24)25/h4-10,18H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182349
(5-(methylsulfonyl)-2-(5-(4-(thiazol-5-yl)phenyl)-3...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(cc1)-c1cncs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O2S2/c1-30(27,28)14-6-7-18(24-9-14)26-15(8-17(25-26)19(20,21)22)12-2-4-13(5-3-12)16-10-23-11-29-16/h2-11H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137418
(2-(3-Difluoromethyl-5-p-tolyl-pyrazol-1-yl)-5-meth...)Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C17H15F2N3O2S/c1-11-3-5-12(6-4-11)15-9-14(17(18)19)21-22(15)16-8-7-13(10-20-16)25(2,23)24/h3-10,17H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137432
(2-(3-Difluoromethyl-4-methyl-5-phenyl-pyrazol-1-yl...)Show SMILES Cc1c(nn(c1-c1ccccc1)-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C17H15F2N3O2S/c1-11-15(17(18)19)21-22(16(11)12-6-4-3-5-7-12)14-9-8-13(10-20-14)25(2,23)24/h3-10,17H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Canis familiaris) | BDBM50137411
(2-[3-Difluoromethyl-5-(4-methoxy-phenyl)-pyrazol-1...)Show SMILES COc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C17H15F2N3O3S/c1-25-12-5-3-11(4-6-12)15-9-14(17(18)19)21-22(15)16-8-7-13(10-20-16)26(2,23)24/h3-10,17H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182336
(5-(methylsulfonyl)-2-(5-(4-(thiazol-2-yl)phenyl)-3...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(cc1)-c1nccs1)C(F)(F)F Show InChI InChI=1S/C19H13F3N4O2S2/c1-30(27,28)14-6-7-17(24-11-14)26-15(10-16(25-26)19(20,21)22)12-2-4-13(5-3-12)18-23-8-9-29-18/h2-11H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137416
(2-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyraz...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(F)cc1)C(F)(F)F Show InChI InChI=1S/C16H11F4N3O2S/c1-26(24,25)12-6-7-15(21-9-12)23-13(8-14(22-23)16(18,19)20)10-2-4-11(17)5-3-10/h2-9H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137413
(2-[5-(4-Chloro-phenyl)-3-trifluoromethyl-pyrazol-1...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Cl)cc1)C(F)(F)F Show InChI InChI=1S/C16H11ClF3N3O2S/c1-26(24,25)12-6-7-15(21-9-12)23-13(8-14(22-23)16(18,19)20)10-2-4-11(17)5-3-10/h2-9H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137415
(5-Methanesulfonyl-2-[5-(4-methoxy-3-methyl-phenyl)...)Show SMILES COc1ccc(cc1C)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C18H16F3N3O3S/c1-11-8-12(4-6-15(11)27-2)14-9-16(18(19,20)21)23-24(14)17-7-5-13(10-22-17)28(3,25)26/h4-10H,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137410
(2-[5-(4-Bromo-phenyl)-3-difluoromethyl-pyrazol-1-y...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(Br)cc1)C(F)F Show InChI InChI=1S/C16H12BrF2N3O2S/c1-25(23,24)12-6-7-15(20-9-12)22-14(8-13(21-22)16(18)19)10-2-4-11(17)5-3-10/h2-9,16H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182337
(2-(5-(2-fluoro-4-(thiazol-4-yl)phenyl)-3-(trifluor...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(cc1F)-c1cscn1)C(F)(F)F Show InChI InChI=1S/C19H12F4N4O2S2/c1-31(28,29)12-3-5-18(24-8-12)27-16(7-17(26-27)19(21,22)23)13-4-2-11(6-14(13)20)15-9-30-10-25-15/h2-10H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137429
(2-[3-Difluoromethyl-5-(4-fluoro-phenyl)-pyrazol-1-...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(F)cc1)C(F)F Show InChI InChI=1S/C16H12F3N3O2S/c1-25(23,24)12-6-7-15(20-9-12)22-14(8-13(21-22)16(18)19)10-2-4-11(17)5-3-10/h2-9,16H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137441
(2-[5-(3-Chloro-4-methoxy-phenyl)-3-trifluoromethyl...)Show SMILES COc1ccc(cc1Cl)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H13ClF3N3O3S/c1-27-14-5-3-10(7-12(14)18)13-8-15(17(19,20)21)23-24(13)16-6-4-11(9-22-16)28(2,25)26/h3-9H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137425
(2-(3-(difluoromethyl)-5-phenyl-1H-pyrazol-1-yl)-5-...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccccc1)C(F)F Show InChI InChI=1S/C16H13F2N3O2S/c1-24(22,23)12-7-8-15(19-10-12)21-14(9-13(20-21)16(17)18)11-5-3-2-4-6-11/h2-10,16H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137421
(2-[5-(3-Fluoro-4-methoxy-phenyl)-3-trifluoromethyl...)Show SMILES COc1ccc(cc1F)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F Show InChI InChI=1S/C17H13F4N3O3S/c1-27-14-5-3-10(7-12(14)18)13-8-15(17(19,20)21)23-24(13)16-6-4-11(9-22-16)28(2,25)26/h3-9H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Canis familiaris) | BDBM50137423
(2-(4-Chloro-3-difluoromethyl-5-phenyl-pyrazol-1-yl...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(C(F)F)c(Cl)c1-c1ccccc1 Show InChI InChI=1S/C16H12ClF2N3O2S/c1-25(23,24)11-7-8-12(20-9-11)22-15(10-5-3-2-4-6-10)13(17)14(21-22)16(18)19/h2-9,16H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 1. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137436
(2-[5-(3-Chloro-4-methoxy-phenyl)-3-difluoromethyl-...)Show SMILES COc1ccc(cc1Cl)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C17H14ClF2N3O3S/c1-26-15-5-3-10(7-12(15)18)14-8-13(17(19)20)22-23(14)16-6-4-11(9-21-16)27(2,24)25/h3-9,17H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137422
(2-[3-Difluoromethyl-5-(2-fluoro-4-methoxy-phenyl)-...)Show SMILES COc1ccc(-c2cc(nn2-c2ccc(cn2)S(C)(=O)=O)C(F)F)c(F)c1 Show InChI InChI=1S/C17H14F3N3O3S/c1-26-10-3-5-12(13(18)7-10)15-8-14(17(19)20)22-23(15)16-6-4-11(9-21-16)27(2,24)25/h3-9,17H,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50137417
(2-[3-Difluoromethyl-5-(4-ethyl-phenyl)-pyrazol-1-y...)Show SMILES CCc1ccc(cc1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)F Show InChI InChI=1S/C18H17F2N3O2S/c1-3-12-4-6-13(7-5-12)16-10-15(18(19)20)22-23(16)17-9-8-14(11-21-17)26(2,24)25/h4-11,18H,3H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against cannine prostaglandin G/H synthase 2. |
Bioorg Med Chem Lett 14: 95-8 (2003)
BindingDB Entry DOI: 10.7270/Q25B01WP |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 2
(Canis familiaris) | BDBM50182350
(2-(furan-2-yl)-5-(1-(5-(methylsulfonyl)pyridin-2-y...)Show SMILES CS(=O)(=O)c1ccc(nc1)-n1nc(cc1-c1ccc(-c2ccco2)c(c1)C(N)=O)C(F)(F)F Show InChI InChI=1S/C21H15F3N4O4S/c1-33(30,31)13-5-7-19(26-11-13)28-16(10-18(27-28)21(22,23)24)12-4-6-14(15(9-12)20(25)29)17-3-2-8-32-17/h2-11H,1H3,(H2,25,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
Veterinary Medicine Research and Development Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of COX2 in canine whole blood |
Bioorg Med Chem Lett 16: 2076-80 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.059
BindingDB Entry DOI: 10.7270/Q28K78PW |
More data for this
Ligand-Target Pair | |
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