Found 66 hits with Last Name = 'kondo' and Initial = 's' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5279173
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5288661
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5276973
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50421186
(CHEMBL2086800)Show SMILES COc1c(C(=O)NCCN2CCCC2)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21 Show InChI InChI=1S/C28H30N4O4/c1-30-24-20-12-6-7-13-21(20)32(18-22(33)19-10-4-3-5-11-19)28(35)23(24)26(36-2)25(30)27(34)29-14-17-31-15-8-9-16-31/h3-7,10-13H,8-9,14-18H2,1-2H3,(H,29,34) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge... |
Bioorg Med Chem 20: 5496-506 (2012)
Article DOI: 10.1016/j.bmc.2012.07.039 BindingDB Entry DOI: 10.7270/Q2N017TJ |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5282804
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50401323
(CHEMBL2205230)Show SMILES CCc1cc2n(C)c(C(=O)NC3CCN(CC3)C(=O)CO)c(OCC(F)(F)F)c2c(=O)n1CC(=O)c1ccccc1 Show InChI InChI=1S/C28H31F3N4O6/c1-3-19-13-20-23(27(40)35(19)14-21(37)17-7-5-4-6-8-17)25(41-16-28(29,30)31)24(33(20)2)26(39)32-18-9-11-34(12-10-18)22(38)15-36/h4-8,13,18,36H,3,9-12,14-16H2,1-2H3,(H,32,39) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re... |
Bioorg Med Chem 20: 5507-17 (2012)
Article DOI: 10.1016/j.bmc.2012.07.034 BindingDB Entry DOI: 10.7270/Q2ZS2XP4 |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50401324
(CHEMBL2205229)Show SMILES CCc1cc2n(C)c(C(=O)NC3CCN(CC3)C(=O)CO)c(OCC(F)F)c2c(=O)n1CC(=O)c1ccccc1 Show InChI InChI=1S/C28H32F2N4O6/c1-3-19-13-20-24(28(39)34(19)14-21(36)17-7-5-4-6-8-17)26(40-16-22(29)30)25(32(20)2)27(38)31-18-9-11-33(12-10-18)23(37)15-35/h4-8,13,18,22,35H,3,9-12,14-16H2,1-2H3,(H,31,38) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re... |
Bioorg Med Chem 20: 5507-17 (2012)
Article DOI: 10.1016/j.bmc.2012.07.034 BindingDB Entry DOI: 10.7270/Q2ZS2XP4 |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5271033
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50401328
(CHEMBL2087239)Show SMILES COc1c(C(=O)NC2CCN(CC2)C(=O)CO)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21 Show InChI InChI=1S/C29H30N4O6/c1-31-25-20-10-6-7-11-21(20)33(16-22(35)18-8-4-3-5-9-18)29(38)24(25)27(39-2)26(31)28(37)30-19-12-14-32(15-13-19)23(36)17-34/h3-11,19,34H,12-17H2,1-2H3,(H,30,37) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re... |
Bioorg Med Chem 20: 5507-17 (2012)
Article DOI: 10.1016/j.bmc.2012.07.034 BindingDB Entry DOI: 10.7270/Q2ZS2XP4 |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50401328
(CHEMBL2087239)Show SMILES COc1c(C(=O)NC2CCN(CC2)C(=O)CO)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21 Show InChI InChI=1S/C29H30N4O6/c1-31-25-20-10-6-7-11-21(20)33(16-22(35)18-8-4-3-5-9-18)29(38)24(25)27(39-2)26(31)28(37)30-19-12-14-32(15-13-19)23(36)17-34/h3-11,19,34H,12-17H2,1-2H3,(H,30,37) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge... |
Bioorg Med Chem 20: 5496-506 (2012)
Article DOI: 10.1016/j.bmc.2012.07.039 BindingDB Entry DOI: 10.7270/Q2N017TJ |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5269674
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50401325
(CHEMBL2205228)Show SMILES CCc1cc2n(C)c(C(=O)NC3CCN(CC3)C(=O)CO)c(OCCF)c2c(=O)n1CC(=O)c1ccccc1 Show InChI InChI=1S/C28H33FN4O6/c1-3-20-15-21-24(28(38)33(20)16-22(35)18-7-5-4-6-8-18)26(39-14-11-29)25(31(21)2)27(37)30-19-9-12-32(13-10-19)23(36)17-34/h4-8,15,19,34H,3,9-14,16-17H2,1-2H3,(H,30,37) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re... |
Bioorg Med Chem 20: 5507-17 (2012)
Article DOI: 10.1016/j.bmc.2012.07.034 BindingDB Entry DOI: 10.7270/Q2ZS2XP4 |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5289771
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50421184
(CHEMBL2086798)Show SMILES COc1c(sc2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21)C(=O)NCCN1CCCC1 Show InChI InChI=1S/C27H27N3O4S/c1-34-23-22-24(35-25(23)26(32)28-13-16-29-14-7-8-15-29)19-11-5-6-12-20(19)30(27(22)33)17-21(31)18-9-3-2-4-10-18/h2-6,9-12H,7-8,13-17H2,1H3,(H,28,32) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge... |
Bioorg Med Chem 20: 5496-506 (2012)
Article DOI: 10.1016/j.bmc.2012.07.039 BindingDB Entry DOI: 10.7270/Q2N017TJ |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50401329
(CHEMBL2205225)Show SMILES CCc1cc2n(C)c(C(=O)NC3CCN(CC3)C(=O)CO)c(OC)c2c(=O)n1CC(=O)c1ccccc1 Show InChI InChI=1S/C27H32N4O6/c1-4-19-14-20-23(27(36)31(19)15-21(33)17-8-6-5-7-9-17)25(37-3)24(29(20)2)26(35)28-18-10-12-30(13-11-18)22(34)16-32/h5-9,14,18,32H,4,10-13,15-16H2,1-3H3,(H,28,35) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re... |
Bioorg Med Chem 20: 5507-17 (2012)
Article DOI: 10.1016/j.bmc.2012.07.034 BindingDB Entry DOI: 10.7270/Q2ZS2XP4 |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5284673
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50421190
(CHEMBL2086805)Show SMILES COc1c(C(=O)NC2CCN(CCO)CC2)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21 Show InChI InChI=1S/C29H32N4O5/c1-31-25-21-10-6-7-11-22(21)33(18-23(35)19-8-4-3-5-9-19)29(37)24(25)27(38-2)26(31)28(36)30-20-12-14-32(15-13-20)16-17-34/h3-11,20,34H,12-18H2,1-2H3,(H,30,36) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge... |
Bioorg Med Chem 20: 5496-506 (2012)
Article DOI: 10.1016/j.bmc.2012.07.039 BindingDB Entry DOI: 10.7270/Q2N017TJ |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50401326
(CHEMBL2205227)Show SMILES CCOc1c(C(=O)NC2CCN(CC2)C(=O)CO)n(C)c2cc(CC)n(CC(=O)c3ccccc3)c(=O)c12 Show InChI InChI=1S/C28H34N4O6/c1-4-20-15-21-24(28(37)32(20)16-22(34)18-9-7-6-8-10-18)26(38-5-2)25(30(21)3)27(36)29-19-11-13-31(14-12-19)23(35)17-33/h6-10,15,19,33H,4-5,11-14,16-17H2,1-3H3,(H,29,36) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re... |
Bioorg Med Chem 20: 5507-17 (2012)
Article DOI: 10.1016/j.bmc.2012.07.034 BindingDB Entry DOI: 10.7270/Q2ZS2XP4 |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50421187
(CHEMBL2086801)Show SMILES CCOc1c(C(=O)NCCN2CCCC2)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21 Show InChI InChI=1S/C29H32N4O4/c1-3-37-27-24-25(31(2)26(27)28(35)30-15-18-32-16-9-10-17-32)21-13-7-8-14-22(21)33(29(24)36)19-23(34)20-11-5-4-6-12-20/h4-8,11-14H,3,9-10,15-19H2,1-2H3,(H,30,35) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge... |
Bioorg Med Chem 20: 5496-506 (2012)
Article DOI: 10.1016/j.bmc.2012.07.039 BindingDB Entry DOI: 10.7270/Q2N017TJ |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | BDBM50583519
(OV-935 | OV935 | SOTICLESTAT | Soticlestat | TAK-9...)Show SMILES OC1(Cc2ccccc2)CCN(CC1)C(=O)c1cccnc1-c1ccncc1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB
| n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5275089
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5275183
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50421193
(CHEMBL2086802)Show SMILES COc1c(C(=O)NCCN2CCCCC2)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21 Show InChI InChI=1S/C29H32N4O4/c1-31-25-21-13-7-8-14-22(21)33(19-23(34)20-11-5-3-6-12-20)29(36)24(25)27(37-2)26(31)28(35)30-15-18-32-16-9-4-10-17-32/h3,5-8,11-14H,4,9-10,15-19H2,1-2H3,(H,30,35) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge... |
Bioorg Med Chem 20: 5496-506 (2012)
Article DOI: 10.1016/j.bmc.2012.07.039 BindingDB Entry DOI: 10.7270/Q2N017TJ |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50401330
(CHEMBL2205224)Show SMILES COc1c(C(=O)NC2CCN(CC2)C(=O)CO)n(C)c2cc(C)n(CC(=O)c3ccccc3)c(=O)c12 Show InChI InChI=1S/C26H30N4O6/c1-16-13-19-22(26(35)30(16)14-20(32)17-7-5-4-6-8-17)24(36-3)23(28(19)2)25(34)27-18-9-11-29(12-10-18)21(33)15-31/h4-8,13,18,31H,9-12,14-15H2,1-3H3,(H,27,34) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re... |
Bioorg Med Chem 20: 5507-17 (2012)
Article DOI: 10.1016/j.bmc.2012.07.034 BindingDB Entry DOI: 10.7270/Q2ZS2XP4 |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5286208
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5274224
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50421189
(CHEMBL2086804)Show SMILES COc1c(C(=O)NC2CCNCC2)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21 Show InChI InChI=1S/C27H28N4O4/c1-30-23-19-10-6-7-11-20(19)31(16-21(32)17-8-4-3-5-9-17)27(34)22(23)25(35-2)24(30)26(33)29-18-12-14-28-15-13-18/h3-11,18,28H,12-16H2,1-2H3,(H,29,33) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge... |
Bioorg Med Chem 20: 5496-506 (2012)
Article DOI: 10.1016/j.bmc.2012.07.039 BindingDB Entry DOI: 10.7270/Q2N017TJ |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5269081
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50421188
(CHEMBL2086803)Show SMILES COc1c(C(=O)NCCN2CCOCC2)n(C)c2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21 Show InChI InChI=1S/C28H30N4O5/c1-30-24-20-10-6-7-11-21(20)32(18-22(33)19-8-4-3-5-9-19)28(35)23(24)26(36-2)25(30)27(34)29-12-13-31-14-16-37-17-15-31/h3-11H,12-18H2,1-2H3,(H,29,34) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge... |
Bioorg Med Chem 20: 5496-506 (2012)
Article DOI: 10.1016/j.bmc.2012.07.039 BindingDB Entry DOI: 10.7270/Q2N017TJ |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5272679
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5285548
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5282243
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5267408
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5288871
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50401327
(CHEMBL2205226)Show SMILES CCc1c(C(=O)NC2CCN(CC2)C(=O)CO)n(C)c2cc(CC)n(CC(=O)c3ccccc3)c(=O)c12 Show InChI InChI=1S/C28H34N4O5/c1-4-20-15-22-25(28(37)32(20)16-23(34)18-9-7-6-8-10-18)21(5-2)26(30(22)3)27(36)29-19-11-13-31(14-12-19)24(35)17-33/h6-10,15,19,33H,4-5,11-14,16-17H2,1-3H3,(H,29,36) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re... |
Bioorg Med Chem 20: 5507-17 (2012)
Article DOI: 10.1016/j.bmc.2012.07.034 BindingDB Entry DOI: 10.7270/Q2ZS2XP4 |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50401331
(CHEMBL2205231)Show SMILES COc1c(C(=O)NC2CCN(CC2)C(=O)CO)n(C)c2c3CCCCc3n(CC(=O)c3ccccc3)c(=O)c12 Show InChI InChI=1S/C29H34N4O6/c1-31-25-20-10-6-7-11-21(20)33(16-22(35)18-8-4-3-5-9-18)29(38)24(25)27(39-2)26(31)28(37)30-19-12-14-32(15-13-19)23(36)17-34/h3-5,8-9,19,34H,6-7,10-17H2,1-2H3,(H,30,37) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh-N expressed in mouse NIH3T3/Gli-luc cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase re... |
Bioorg Med Chem 20: 5507-17 (2012)
Article DOI: 10.1016/j.bmc.2012.07.034 BindingDB Entry DOI: 10.7270/Q2ZS2XP4 |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5269664
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50421191
(CHEMBL2086402)Show SMILES CCC(=O)Cn1c2ccccc2c2n(C)c(C(=O)NC3CCN(CCO)CC3)c(OC)c2c1=O Show InChI InChI=1S/C25H32N4O5/c1-4-17(31)15-29-19-8-6-5-7-18(19)21-20(25(29)33)23(34-3)22(27(21)2)24(32)26-16-9-11-28(12-10-16)13-14-30/h5-8,16,30H,4,9-15H2,1-3H3,(H,26,32) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge... |
Bioorg Med Chem 20: 5496-506 (2012)
Article DOI: 10.1016/j.bmc.2012.07.039 BindingDB Entry DOI: 10.7270/Q2N017TJ |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5288993
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5275961
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50421192
(CHEMBL2087240)Show SMILES COc1c(C(=O)NC2CCN(CCO)CC2)n(C)c2c1c(=O)n(CCc1ccccc1)c1ccccc21 Show InChI InChI=1S/C29H34N4O4/c1-31-25-22-10-6-7-11-23(22)33(17-12-20-8-4-3-5-9-20)29(36)24(25)27(37-2)26(31)28(35)30-21-13-15-32(16-14-21)18-19-34/h3-11,21,34H,12-19H2,1-2H3,(H,30,35) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge... |
Bioorg Med Chem 20: 5496-506 (2012)
Article DOI: 10.1016/j.bmc.2012.07.039 BindingDB Entry DOI: 10.7270/Q2N017TJ |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5266978
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50540140
(CHEMBL4643958)Show InChI InChI=1S/C16H10N2O2/c19-11-7-5-10(6-8-11)18-15-14(9-17-18)12-3-1-2-4-13(12)16(15)20/h1-9,19H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Institute of Innovative Research
Curated by ChEMBL
| Assay Description Inhibition of HIF1alpha transcriptional activity in human HeLa cells transfected with HRE-firefly luciferase and cytomegalovirus-promoter expressing ... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2019.115207 BindingDB Entry DOI: 10.7270/Q2KP85Q9 |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5291094
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50540144
(CHEMBL4645257)Show InChI InChI=1S/C17H12N2O2/c1-21-12-8-6-11(7-9-12)19-16-15(10-18-19)13-4-2-3-5-14(13)17(16)20/h2-10H,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Institute of Innovative Research
Curated by ChEMBL
| Assay Description Inhibition of HIF1alpha transcriptional activity in human HeLa cells transfected with HRE-firefly luciferase and cytomegalovirus-promoter expressing ... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2019.115207 BindingDB Entry DOI: 10.7270/Q2KP85Q9 |
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50540145
(CHEMBL4635527)Show InChI InChI=1S/C17H12N2O/c1-11-6-8-12(9-7-11)19-16-15(10-18-19)13-4-2-3-5-14(13)17(16)20/h2-10H,1H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Institute of Innovative Research
Curated by ChEMBL
| Assay Description Inhibition of HIF1alpha transcriptional activity in human HeLa cells transfected with HRE-firefly luciferase and cytomegalovirus-promoter expressing ... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2019.115207 BindingDB Entry DOI: 10.7270/Q2KP85Q9 |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50421185
(CHEMBL2086799)Show SMILES COc1c(oc2c1c(=O)n(CC(=O)c1ccccc1)c1ccccc21)C(=O)NCCN1CCCC1 Show InChI InChI=1S/C27H27N3O5/c1-34-24-22-23(35-25(24)26(32)28-13-16-29-14-7-8-15-29)19-11-5-6-12-20(19)30(27(22)33)17-21(31)18-9-3-2-4-10-18/h2-6,9-12H,7-8,13-17H2,1H3,(H,28,32) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description Inhibition of recombinant mouse Shh expressed in human NIH/3T3 cells assessed as inhibition of Gli1 expression after 48 hrs by luciferase reporter ge... |
Bioorg Med Chem 20: 5496-506 (2012)
Article DOI: 10.1016/j.bmc.2012.07.039 BindingDB Entry DOI: 10.7270/Q2N017TJ |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5285292
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50540147
(CHEMBL4648415)Show InChI InChI=1S/C16H10N2O/c19-16-13-9-5-4-8-12(13)14-10-17-18(15(14)16)11-6-2-1-3-7-11/h1-10H | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo Institute of Innovative Research
Curated by ChEMBL
| Assay Description Inhibition of HIF1alpha transcriptional activity in human HeLa cells transfected with HRE-firefly luciferase and cytomegalovirus-promoter expressing ... |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2019.115207 BindingDB Entry DOI: 10.7270/Q2KP85Q9 |
More data for this Ligand-Target Pair | |
Cholesterol 24-hydroxylase
(Homo sapiens (Human)) | CHEMBL5272278
| PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |