Found 407 hits with Last Name = 'koul' and Initial = 's' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231595
(CHEMBL4092832)Show SMILES CCCn1c(nc2nc([nH]c2c1=O)C1CCCC1)-c1cccc(O)c1 Show InChI InChI=1S/C19H22N4O2/c1-2-10-23-18(13-8-5-9-14(24)11-13)22-17-15(19(23)25)20-16(21-17)12-6-3-4-7-12/h5,8-9,11-12,24H,2-4,6-7,10H2,1H3,(H,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231590
(CHEMBL4063997)Show InChI InChI=1S/C19H23N5O2/c1-3-11-24-18(25)15-17(22-16(21-15)13-7-4-5-8-13)23-19(24)26-14-9-6-10-20-12(14)2/h6,9-10,13H,3-5,7-8,11H2,1-2H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231595
(CHEMBL4092832)Show SMILES CCCn1c(nc2nc([nH]c2c1=O)C1CCCC1)-c1cccc(O)c1 Show InChI InChI=1S/C19H22N4O2/c1-2-10-23-18(13-8-5-9-14(24)11-13)22-17-15(19(23)25)20-16(21-17)12-6-3-4-7-12/h5,8-9,11-12,24H,2-4,6-7,10H2,1H3,(H,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231589
(CHEMBL4073088)Show SMILES CCCn1c(Oc2cncc(Cl)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C18H20ClN5O2/c1-2-7-24-17(25)14-16(22-15(21-14)11-5-3-4-6-11)23-18(24)26-13-8-12(19)9-20-10-13/h8-11H,2-7H2,1H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231597
(CHEMBL4102409)Show SMILES CCCn1c(Oc2cccc(OC)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C20H24N4O3/c1-3-11-24-19(25)16-18(22-17(21-16)13-7-4-5-8-13)23-20(24)27-15-10-6-9-14(12-15)26-2/h6,9-10,12-13H,3-5,7-8,11H2,1-2H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231709
(CHEMBL4083067)Show SMILES CCCn1c(Oc2cccnc2Cl)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C18H20ClN5O2/c1-2-10-24-17(25)13-16(22-15(21-13)11-6-3-4-7-11)23-18(24)26-12-8-5-9-20-14(12)19/h5,8-9,11H,2-4,6-7,10H2,1H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231707
(CHEMBL4085564)Show SMILES CCCn1c(Oc2cccc3cc[nH]c23)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C21H23N5O2/c1-2-12-26-20(27)17-19(24-18(23-17)14-6-3-4-7-14)25-21(26)28-15-9-5-8-13-10-11-22-16(13)15/h5,8-11,14,22H,2-4,6-7,12H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231707
(CHEMBL4085564)Show SMILES CCCn1c(Oc2cccc3cc[nH]c23)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C21H23N5O2/c1-2-12-26-20(27)17-19(24-18(23-17)14-6-3-4-7-14)25-21(26)28-15-9-5-8-13-10-11-22-16(13)15/h5,8-11,14,22H,2-4,6-7,12H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231588
(CHEMBL4084453)Show SMILES CCCn1c(Oc2cccc(c2)C(F)(F)F)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C20H21F3N4O2/c1-2-10-27-18(28)15-17(25-16(24-15)12-6-3-4-7-12)26-19(27)29-14-9-5-8-13(11-14)20(21,22)23/h5,8-9,11-12H,2-4,6-7,10H2,1H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 5.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231590
(CHEMBL4063997)Show InChI InChI=1S/C19H23N5O2/c1-3-11-24-18(25)15-17(22-16(21-15)13-7-4-5-8-13)23-19(24)26-14-9-6-10-20-12(14)2/h6,9-10,13H,3-5,7-8,11H2,1-2H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 6.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231593
(CHEMBL4068469)Show SMILES CCCn1c(OC2CCC(O)C2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C18H26N4O3/c1-2-9-22-17(24)14-16(20-15(19-14)11-5-3-4-6-11)21-18(22)25-13-8-7-12(23)10-13/h11-13,23H,2-10H2,1H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 9.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231710
(CHEMBL4101044)Show SMILES CCCn1c(Oc2cccc(O)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C19H22N4O3/c1-2-10-23-18(25)15-17(21-16(20-15)12-6-3-4-7-12)22-19(23)26-14-9-5-8-13(24)11-14/h5,8-9,11-12,24H,2-4,6-7,10H2,1H3,(H,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231589
(CHEMBL4073088)Show SMILES CCCn1c(Oc2cncc(Cl)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C18H20ClN5O2/c1-2-7-24-17(25)14-16(22-15(21-14)11-5-3-4-6-11)23-18(24)26-13-8-12(19)9-20-10-13/h8-11H,2-7H2,1H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231715
(CHEMBL4088084)Show SMILES CCCn1c(nc2nc([nH]c2c1=O)C1CCCC1)-c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C20H21F3N4O/c1-2-10-27-18(13-8-5-9-14(11-13)20(21,22)23)26-17-15(19(27)28)24-16(25-17)12-6-3-4-7-12/h5,8-9,11-12H,2-4,6-7,10H2,1H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231592
(CHEMBL4078636)Show InChI InChI=1S/C18H26N4O3/c1-2-9-22-17(23)14-16(20-15(19-14)12-5-3-4-6-12)21-18(22)25-13-7-10-24-11-8-13/h12-13H,2-11H2,1H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231591
(CHEMBL4090857)Show InChI InChI=1S/C18H26N4O2/c1-2-11-22-17(23)14-16(20-15(19-14)12-7-3-4-8-12)21-18(22)24-13-9-5-6-10-13/h12-13H,2-11H2,1H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231597
(CHEMBL4102409)Show SMILES CCCn1c(Oc2cccc(OC)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C20H24N4O3/c1-3-11-24-19(25)16-18(22-17(21-16)13-7-4-5-8-13)23-20(24)27-15-10-6-9-14(12-15)26-2/h6,9-10,12-13H,3-5,7-8,11H2,1-2H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231596
(CHEMBL4074150)Show SMILES CCCn1c(Oc2ccc(F)c(F)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C19H20F2N4O2/c1-2-9-25-18(26)15-17(23-16(22-15)11-5-3-4-6-11)24-19(25)27-12-7-8-13(20)14(21)10-12/h7-8,10-11H,2-6,9H2,1H3,(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231591
(CHEMBL4090857)Show InChI InChI=1S/C18H26N4O2/c1-2-11-22-17(23)14-16(20-15(19-14)12-7-3-4-8-12)21-18(22)24-13-9-5-6-10-13/h12-13H,2-11H2,1H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231594
(CHEMBL4065762)Show SMILES CCCn1c(nc2nc([nH]c2c1=O)C1CCCC1)-c1cccc(OC)c1 Show InChI InChI=1S/C20H24N4O2/c1-3-11-24-19(14-9-6-10-15(12-14)26-2)23-18-16(20(24)25)21-17(22-18)13-7-4-5-8-13/h6,9-10,12-13H,3-5,7-8,11H2,1-2H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A1 receptor expressed in HEK293 cells assessed as reduction in CPA-mediated inhibition of forskolin-stimulated... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231594
(CHEMBL4065762)Show SMILES CCCn1c(nc2nc([nH]c2c1=O)C1CCCC1)-c1cccc(OC)c1 Show InChI InChI=1S/C20H24N4O2/c1-3-11-24-19(14-9-6-10-15(12-14)26-2)23-18-16(20(24)25)21-17(22-18)13-7-4-5-8-13/h6,9-10,12-13H,3-5,7-8,11H2,1-2H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231588
(CHEMBL4084453)Show SMILES CCCn1c(Oc2cccc(c2)C(F)(F)F)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C20H21F3N4O2/c1-2-10-27-18(28)15-17(25-16(24-15)12-6-3-4-7-12)26-19(27)29-14-9-5-8-13(11-14)20(21,22)23/h5,8-9,11-12H,2-4,6-7,10H2,1H3,(H,24,25) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231592
(CHEMBL4078636)Show InChI InChI=1S/C18H26N4O3/c1-2-9-22-17(23)14-16(20-15(19-14)12-5-3-4-6-12)21-18(22)25-13-7-10-24-11-8-13/h12-13H,2-11H2,1H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231598
(CHEMBL4101929)Show SMILES CCCn1c(NCc2ccc(cc2)C(F)(F)F)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C21H24F3N5O/c1-2-11-29-19(30)16-18(27-17(26-16)14-5-3-4-6-14)28-20(29)25-12-13-7-9-15(10-8-13)21(22,23)24/h7-10,14H,2-6,11-12H2,1H3,(H,25,28)(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231596
(CHEMBL4074150)Show SMILES CCCn1c(Oc2ccc(F)c(F)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C19H20F2N4O2/c1-2-9-25-18(26)15-17(23-16(22-15)11-5-3-4-6-11)24-19(25)27-12-7-8-13(20)14(21)10-12/h7-8,10-11H,2-6,9H2,1H3,(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231718
(CHEMBL4073565)Show SMILES CCCn1c(NCc2ccc(C)cc2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C21H27N5O/c1-3-12-26-20(27)17-19(24-18(23-17)16-6-4-5-7-16)25-21(26)22-13-15-10-8-14(2)9-11-15/h8-11,16H,3-7,12-13H2,1-2H3,(H,22,25)(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231704
(CHEMBL4099951)Show SMILES CCCn1c(Oc2ccc3[nH]ccc3c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C21H23N5O2/c1-2-11-26-20(27)17-19(24-18(23-17)13-5-3-4-6-13)25-21(26)28-15-7-8-16-14(12-15)9-10-22-16/h7-10,12-13,22H,2-6,11H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231713
(CHEMBL4059809)Show SMILES [H][C@]1(CCOC1)Oc1nc2nc([nH]c2c(=O)n1CCC)C1CCCC1 |r| Show InChI InChI=1S/C17H24N4O3/c1-2-8-21-16(22)13-15(19-14(18-13)11-5-3-4-6-11)20-17(21)24-12-7-9-23-10-12/h11-12H,2-10H2,1H3,(H,18,19)/t12-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231593
(CHEMBL4068469)Show SMILES CCCn1c(OC2CCC(O)C2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C18H26N4O3/c1-2-9-22-17(24)14-16(20-15(19-14)11-5-3-4-6-11)21-18(22)25-13-8-7-12(23)10-13/h11-13,23H,2-10H2,1H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 57 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231711
(CHEMBL4096654)Show InChI InChI=1S/C17H24N4O3/c1-2-8-21-16(22)13-15(19-14(18-13)11-5-3-4-6-11)20-17(21)24-12-7-9-23-10-12/h11-12H,2-10H2,1H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231708
(CHEMBL4072594)Show SMILES CCCn1c(Oc2cccc3[nH]ccc23)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C21H23N5O2/c1-2-12-26-20(27)17-19(24-18(23-17)13-6-3-4-7-13)25-21(26)28-16-9-5-8-15-14(16)10-11-22-15/h5,8-11,13,22H,2-4,6-7,12H2,1H3,(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231712
(CHEMBL4095810)Show SMILES [H][C@@]1(CCOC1)Oc1nc2nc([nH]c2c(=O)n1CCC)C1CCCC1 |r| Show InChI InChI=1S/C17H24N4O3/c1-2-8-21-16(22)13-15(19-14(18-13)11-5-3-4-6-11)20-17(21)24-12-7-9-23-10-12/h11-12H,2-10H2,1H3,(H,18,19)/t12-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 85 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231599
(CHEMBL4064971)Show SMILES CCCn1c(NCc2cccc(Cl)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C20H24ClN5O/c1-2-10-26-19(27)16-18(24-17(23-16)14-7-3-4-8-14)25-20(26)22-12-13-6-5-9-15(21)11-13/h5-6,9,11,14H,2-4,7-8,10,12H2,1H3,(H,22,25)(H,23,24) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231734
(CHEMBL4067683)Show SMILES CCCn1c(Nc2cccc(c2)C(F)(F)F)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C20H22F3N5O/c1-2-10-28-18(29)15-17(26-16(25-15)12-6-3-4-7-12)27-19(28)24-14-9-5-8-13(11-14)20(21,22)23/h5,8-9,11-12H,2-4,6-7,10H2,1H3,(H,24,27)(H,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM50231590
(CHEMBL4063997)Show InChI InChI=1S/C19H23N5O2/c1-3-11-24-18(25)15-17(22-16(21-15)13-7-4-5-8-13)23-19(24)26-14-9-6-10-20-12(14)2/h6,9-10,13H,3-5,7-8,11H2,1-2H3,(H,21,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 560 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubat... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231703
(CHEMBL4092203)Show SMILES CCCn1c(Oc2ccc(C)nc2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C19H23N5O2/c1-3-10-24-18(25)15-17(22-16(21-15)13-6-4-5-7-13)23-19(24)26-14-9-8-12(2)20-11-14/h8-9,11,13H,3-7,10H2,1-2H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 630 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM50231594
(CHEMBL4065762)Show SMILES CCCn1c(nc2nc([nH]c2c1=O)C1CCCC1)-c1cccc(OC)c1 Show InChI InChI=1S/C20H24N4O2/c1-3-11-24-19(14-9-6-10-15(12-14)26-2)23-18-16(20(24)25)21-17(22-18)13-7-4-5-8-13/h6,9-10,12-13H,3-5,7-8,11H2,1-2H3,(H,21,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 650 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubat... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231716
(CHEMBL4093311)Show SMILES CCCn1c(Oc2cc(C)ccn2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C19H23N5O2/c1-3-10-24-18(25)15-17(22-16(21-15)13-6-4-5-7-13)23-19(24)26-14-11-12(2)8-9-20-14/h8-9,11,13H,3-7,10H2,1-2H3,(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231705
(CHEMBL4083509)Show SMILES CCCn1c(Oc2ccc(cc2)S(N)(=O)=O)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C19H23N5O4S/c1-2-11-24-18(25)15-17(22-16(21-15)12-5-3-4-6-12)23-19(24)28-13-7-9-14(10-8-13)29(20,26)27/h7-10,12H,2-6,11H2,1H3,(H,21,22)(H2,20,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231600
(CHEMBL4078579)Show InChI InChI=1S/C19H23N5O/c1-2-12-24-18(25)15-17(22-16(21-15)13-8-6-7-9-13)23-19(24)20-14-10-4-3-5-11-14/h3-5,10-11,13H,2,6-9,12H2,1H3,(H,20,23)(H,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231601
(CHEMBL4095098)Show SMILES CCCn1c(Nc2ccc(F)cc2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C19H22FN5O/c1-2-11-25-18(26)15-17(23-16(22-15)12-5-3-4-6-12)24-19(25)21-14-9-7-13(20)8-10-14/h7-10,12H,2-6,11H2,1H3,(H,21,24)(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231702
(CHEMBL4064506)Show SMILES CCCn1c(Oc2ccc(cc2)C(N)=O)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C20H23N5O3/c1-2-11-25-19(27)15-18(23-17(22-15)13-5-3-4-6-13)24-20(25)28-14-9-7-12(8-10-14)16(21)26/h7-10,13H,2-6,11H2,1H3,(H2,21,26)(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231717
(CHEMBL4062924)Show SMILES CCCn1c(OC2CCN(C)C2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C18H27N5O2/c1-3-9-23-17(24)14-16(20-15(19-14)12-6-4-5-7-12)21-18(23)25-13-8-10-22(2)11-13/h12-13H,3-11H2,1-2H3,(H,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231706
(CHEMBL4061733)Show SMILES CCCn1c(Oc2cccc(CC(O)=O)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C21H24N4O4/c1-2-10-25-20(28)17-19(23-18(22-17)14-7-3-4-8-14)24-21(25)29-15-9-5-6-13(11-15)12-16(26)27/h5-6,9,11,14H,2-4,7-8,10,12H2,1H3,(H,22,23)(H,26,27) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231714
(CHEMBL4082701)Show SMILES CCCn1c(nc2nc([nH]c2c1=O)C1CCCC1)-c1cccc(c1)C(N)=O Show InChI InChI=1S/C20H23N5O2/c1-2-10-25-19(14-9-5-8-13(11-14)16(21)26)24-18-15(20(25)27)22-17(23-18)12-6-3-4-7-12/h5,8-9,11-12H,2-4,6-7,10H2,1H3,(H2,21,26)(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM50231594
(CHEMBL4065762)Show SMILES CCCn1c(nc2nc([nH]c2c1=O)C1CCCC1)-c1cccc(OC)c1 Show InChI InChI=1S/C20H24N4O2/c1-3-11-24-19(14-9-6-10-15(12-14)26-2)23-18-16(20(24)25)21-17(22-18)13-7-4-5-8-13/h6,9-10,12-13H,3-5,7-8,11H2,1-2H3,(H,21,22) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]MRS-1754 from human adenosine A2B receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM50231590
(CHEMBL4063997)Show InChI InChI=1S/C19H23N5O2/c1-3-11-24-18(25)15-17(22-16(21-15)13-7-4-5-8-13)23-19(24)26-14-9-6-10-20-12(14)2/h6,9-10,13H,3-5,7-8,11H2,1-2H3,(H,21,22) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM50231602
(CHEMBL4094659)Show SMILES CCCn1c(Nc2cccc(F)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C19H22FN5O/c1-2-10-25-18(26)15-17(23-16(22-15)12-6-3-4-7-12)24-19(25)21-14-9-5-8-13(20)11-14/h5,8-9,11-12H,2-4,6-7,10H2,1H3,(H,21,24)(H,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A2a
(Homo sapiens (Human)) | BDBM50231596
(CHEMBL4074150)Show SMILES CCCn1c(Oc2ccc(F)c(F)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C19H20F2N4O2/c1-2-9-25-18(26)15-17(23-16(22-15)11-5-3-4-6-11)24-19(25)27-12-7-8-13(20)14(21)10-12/h7-8,10-11H,2-6,9H2,1H3,(H,22,23) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [3H]ZM241385 from human adenosine A2A receptor expressed in HEK293 cell membranes after 90 mins |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
Adenosine receptor A2b
(Homo sapiens (Human)) | BDBM50231596
(CHEMBL4074150)Show SMILES CCCn1c(Oc2ccc(F)c(F)c2)nc2nc([nH]c2c1=O)C1CCCC1 Show InChI InChI=1S/C19H20F2N4O2/c1-2-9-25-18(26)15-17(23-16(22-15)11-5-3-4-6-11)24-19(25)27-12-7-8-13(20)14(21)10-12/h7-8,10-11H,2-6,9H2,1H3,(H,22,23) | PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Advinus Therapeutics Ltd.
Curated by ChEMBL
| Assay Description
Antagonist activity at human adenosine A2B receptor expressed in HEK293 cells assessed as reduction in NECA-induced increase in cAMP level preincubat... |
Bioorg Med Chem 25: 1963-1975 (2017)
Article DOI: 10.1016/j.bmc.2017.02.029
BindingDB Entry DOI: 10.7270/Q2KH0QKC |
More data for this
Ligand-Target Pair | |
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