Found 167 hits with Last Name = 'koury' and Initial = 'ej' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
DrugBank
MCE
KEGG
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| 2.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243500
((-)-1-[(1S)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)Show SMILES CN1CCN(C[C@H](c2cccc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3/t18-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243503
((+)-1-[(1S)-1-(3-Chlorophenyl)-2-piperazin-1-yleth...)Show SMILES OC1(CCCCC1)[C@H](CN1CCNCC1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C18H27ClN2O/c19-16-6-4-5-15(13-16)17(14-21-11-9-20-10-12-21)18(22)7-2-1-3-8-18/h4-6,13,17,20,22H,1-3,7-12,14H2/t17-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243501
(1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cycloh...)Show InChI InChI=1S/C18H27ClN2O/c19-16-6-4-5-15(13-16)17(14-21-11-9-20-10-12-21)18(22)7-2-1-3-8-18/h4-6,13,17,20,22H,1-3,7-12,14H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50010884
(1-(2-(dimethylamino)-1-(3-(trifluoromethyl)phenyl)...)Show InChI InChI=1S/C17H24F3NO/c1-21(2)12-15(16(22)9-4-3-5-10-16)13-7-6-8-14(11-13)17(18,19)20/h6-8,11,15,22H,3-5,9-10,12H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243464
((-)-1-[(1R)-1-(3-Chlorophenyl)-2-(dimethylamino)et...)Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3/t15-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243501
(1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cycloh...)Show InChI InChI=1S/C18H27ClN2O/c19-16-6-4-5-15(13-16)17(14-21-11-9-20-10-12-21)18(22)7-2-1-3-8-18/h4-6,13,17,20,22H,1-3,7-12,14H2 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]WIN35428 from human recombinant dopamine transporter expressed in CHO cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243468
(1-[1-(3-Chlorophenyl)-2-(4-methylpiperazin-1-yl)et...)Show InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50242927
((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)Show SMILES CN1CCN(C[C@H](c2cccc(OC(F)(F)F)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C20H29F3N2O2/c1-24-10-12-25(13-11-24)15-18(19(26)8-3-2-4-9-19)16-6-5-7-17(14-16)27-20(21,22)23/h5-7,14,18,26H,2-4,8-13,15H2,1H3/t18-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243468
(1-[1-(3-Chlorophenyl)-2-(4-methylpiperazin-1-yl)et...)Show InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]WIN35428 from human recombinant dopamine transporter expressed in CHO cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243017
(1-{2-Piperazin-1-yl-1-[3-(trifluoromethyl)phenyl]e...)Show InChI InChI=1S/C19H27F3N2O/c20-19(21,22)16-6-4-5-15(13-16)17(14-24-11-9-23-10-12-24)18(25)7-2-1-3-8-18/h4-6,13,17,23,25H,1-3,7-12,14H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243016
(1-{2-(3-Methylpiperazin-1-yl)-1-[3-(trifluoromethy...)Show SMILES CN1CCN(CC(c2cccc(c2)C(F)(F)F)C2(O)CCCCC2)CC1 Show InChI InChI=1S/C20H29F3N2O/c1-24-10-12-25(13-11-24)15-18(19(26)8-3-2-4-9-19)16-6-5-7-17(14-16)20(21,22)23/h5-7,14,18,26H,2-4,8-13,15H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243500
((-)-1-[(1S)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)Show SMILES CN1CCN(C[C@H](c2cccc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3/t18-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]WIN35428 from human recombinant dopamine transporter expressed in CHO cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50242925
(1-{2-(3-Methylpiperazin-1-yl)-1-[3-(trifluorometho...)Show SMILES CN1CCN(CC(c2cccc(OC(F)(F)F)c2)C2(O)CCCCC2)CC1 Show InChI InChI=1S/C20H29F3N2O2/c1-24-10-12-25(13-11-24)15-18(19(26)8-3-2-4-9-19)16-6-5-7-17(14-16)27-20(21,22)23/h5-7,14,18,26H,2-4,8-13,15H2,1H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243015
((+)-1-{(1S)-2-Piperazin-1-yl-1-[3-(trifluoromethox...)Show SMILES OC1(CCCCC1)[C@H](CN1CCNCC1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C19H27F3N2O2/c20-19(21,22)26-16-6-4-5-15(13-16)17(14-24-11-9-23-10-12-24)18(25)7-2-1-3-8-18/h4-6,13,17,23,25H,1-3,7-12,14H2/t17-/m1/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 117 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50010860
(1-(1-(2-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-14(13-8-4-5-9-15(13)17)16(19)10-6-3-7-11-16/h4-5,8-9,14,19H,3,6-7,10-12H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243503
((+)-1-[(1S)-1-(3-Chlorophenyl)-2-piperazin-1-yleth...)Show SMILES OC1(CCCCC1)[C@H](CN1CCNCC1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C18H27ClN2O/c19-16-6-4-5-15(13-16)17(14-21-11-9-20-10-12-21)18(22)7-2-1-3-8-18/h4-6,13,17,20,22H,1-3,7-12,14H2/t17-/m1/s1 | NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 135 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]WIN35428 from human recombinant dopamine transporter expressed in CHO cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243013
(1-{2-Piperazin-1-yl-1-[3-(trifluoromethoxy)phenyl]...)Show InChI InChI=1S/C19H27F3N2O2/c20-19(21,22)26-16-6-4-5-15(13-16)17(14-24-11-9-23-10-12-24)18(25)7-2-1-3-8-18/h4-6,13,17,23,25H,1-3,7-12,14H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50010858
(1-(1-(3-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 149 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243469
((+)-1-[(1R)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)Show SMILES CN1CCN(C[C@@H](c2cccc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3/t18-/m0/s1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 187 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243502
((-)-1-[(1R)-1-(3-Chlorophenyl)-2-piperazin-1-yleth...)Show SMILES OC1(CCCCC1)[C@@H](CN1CCNCC1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C18H27ClN2O/c19-16-6-4-5-15(13-16)17(14-21-11-9-20-10-12-21)18(22)7-2-1-3-8-18/h4-6,13,17,20,22H,1-3,7-12,14H2/t17-/m0/s1 | Reactome pathway
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| 214 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243469
((+)-1-[(1R)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)Show SMILES CN1CCN(C[C@@H](c2cccc(Cl)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C19H29ClN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3/t18-/m0/s1 | NCI pathway
Reactome pathway
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| 235 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]WIN35428 from human recombinant dopamine transporter expressed in CHO cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50010874
(1-(1-(4-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-15(13-6-8-14(17)9-7-13)16(19)10-4-3-5-11-16/h6-9,15,19H,3-5,10-12H2,1-2H3 | Reactome pathway
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| 249 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50010879
(1-(2-(dimethylamino)-1-(3-methoxyphenyl)ethyl)cycl...)Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)10-5-4-6-11-17)14-8-7-9-15(12-14)20-3/h7-9,12,16,19H,4-6,10-11,13H2,1-3H3 | Reactome pathway
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| 316 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243465
((+)-1-[(1S)-1-(3-Chlorophenyl)-2-(dimethylamino)et...)Show InChI InChI=1S/C16H24ClNO/c1-18(2)12-15(13-7-6-8-14(17)11-13)16(19)9-4-3-5-10-16/h6-8,11,15,19H,3-5,9-10,12H2,1-2H3/t15-/m1/s1 | Reactome pathway
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| 339 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50243502
((-)-1-[(1R)-1-(3-Chlorophenyl)-2-piperazin-1-yleth...)Show SMILES OC1(CCCCC1)[C@@H](CN1CCNCC1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C18H27ClN2O/c19-16-6-4-5-15(13-16)17(14-21-11-9-20-10-12-21)18(22)7-2-1-3-8-18/h4-6,13,17,20,22H,1-3,7-12,14H2/t17-/m0/s1 | NCI pathway
Reactome pathway
KEGG
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PubMed
| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]WIN35428 from human recombinant dopamine transporter expressed in CHO cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243011
(1-[1-(3-Fluorophenyl)-2-(4-methylpiperazin-1-yl)et...)Show InChI InChI=1S/C19H29FN2O/c1-21-10-12-22(13-11-21)15-18(16-6-5-7-17(20)14-16)19(23)8-3-2-4-9-19/h5-7,14,18,23H,2-4,8-13,15H2,1H3 | Reactome pathway
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| 364 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243012
(1-[1-(3-Fluorophenyl)-2-piperazin-1-ylethyl]cycloh...)Show InChI InChI=1S/C18H27FN2O/c19-16-6-4-5-15(13-16)17(14-21-11-9-20-10-12-21)18(22)7-2-1-3-8-18/h4-6,13,17,20,22H,1-3,7-12,14H2 | Reactome pathway
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| 368 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM82071
(CAS_93413-69-5 | CAS_99300-78-4 | NSC_62923 | VENL...)Show InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 | Reactome pathway
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Article
PubMed
| 385 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243504
(1-{2-(4-Methylpiperazin-1-yl)-1-[4-(trifluorometho...)Show SMILES CN1CCN(CC(c2ccc(OC(F)(F)F)cc2)C2(O)CCCCC2)CC1 Show InChI InChI=1S/C20H29F3N2O2/c1-24-11-13-25(14-12-24)15-18(19(26)9-3-2-4-10-19)16-5-7-17(8-6-16)27-20(21,22)23/h5-8,18,26H,2-4,9-15H2,1H3 | Reactome pathway
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| 417 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50242922
(1-[1-(3-Methoxyphenyl)-2-(4-methyl-1-piperazinyl)e...)Show InChI InChI=1S/C20H32N2O2/c1-21-11-13-22(14-12-21)16-19(20(23)9-4-3-5-10-20)17-7-6-8-18(15-17)24-2/h6-8,15,19,23H,3-5,9-14,16H2,1-2H3 | Reactome pathway
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| 514 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50242921
(1-[1-(4-Methoxyphenyl)-2-piperazin-1-ylethyl]cyclo...)Show InChI InChI=1S/C19H30N2O2/c1-23-17-7-5-16(6-8-17)18(15-21-13-11-20-12-14-21)19(22)9-3-2-4-10-19/h5-8,18,20,22H,2-4,9-15H2,1H3 | Reactome pathway
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| 519 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243014
((-)-1-{(1R)-2-Piperazin-1-yl-1-[3-(trifluoromethox...)Show SMILES OC1(CCCCC1)[C@@H](CN1CCNCC1)c1cccc(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C19H27F3N2O2/c20-19(21,22)26-16-6-4-5-15(13-16)17(14-24-11-9-23-10-12-24)18(25)7-2-1-3-8-18/h4-6,13,17,23,25H,1-3,7-12,14H2/t17-/m0/s1 | Reactome pathway
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| 544 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243467
(1-[1-(4-Chlorophenyl)-2-piperazin-1-ylethyl]cycloh...)Show InChI InChI=1S/C18H27ClN2O/c19-16-6-4-15(5-7-16)17(14-21-12-10-20-11-13-21)18(22)8-2-1-3-9-18/h4-7,17,20,22H,1-3,8-14H2 | Reactome pathway
KEGG
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| 717 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50242923
(1-[1-(3-Methoxyphenyl)-2-piperazin-1-ylethyl]cyclo...)Show InChI InChI=1S/C19H30N2O2/c1-23-17-7-5-6-16(14-17)18(15-21-12-10-20-11-13-21)19(22)8-3-2-4-9-19/h5-7,14,18,20,22H,2-4,8-13,15H2,1H3 | Reactome pathway
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| 745 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50242926
((+)-1-{(1R)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)Show SMILES CN1CCN(C[C@@H](c2cccc(OC(F)(F)F)c2)C2(O)CCCCC2)CC1 |r| Show InChI InChI=1S/C20H29F3N2O2/c1-24-10-12-25(13-11-24)15-18(19(26)8-3-2-4-9-19)16-6-5-7-17(14-16)27-20(21,22)23/h5-7,14,18,26H,2-4,8-13,15H2,1H3/t18-/m0/s1 | Reactome pathway
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| 785 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243010
(1-[1-(4-Fluorophenyl)-2-piperazin-1-ylethyl]cycloh...)Show InChI InChI=1S/C18H27FN2O/c19-16-6-4-15(5-7-16)17(14-21-12-10-20-11-13-21)18(22)8-2-1-3-9-18/h4-7,17,20,22H,1-3,8-14H2 | Reactome pathway
KEGG
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Similars
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| 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243466
(1-[1-(4-Chlorophenyl)-2-(4-methylpiperazin-1-yl)et...)Show InChI InChI=1S/C19H29ClN2O/c1-21-11-13-22(14-12-21)15-18(16-5-7-17(20)8-6-16)19(23)9-3-2-4-10-19/h5-8,18,23H,2-4,9-15H2,1H3 | Reactome pathway
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| 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50243009
(1-[1-(4-Fluorophenyl)-2-(4-methylpiperazin-1-yl)et...)Show InChI InChI=1S/C19H29FN2O/c1-21-11-13-22(14-12-21)15-18(16-5-7-17(20)8-6-16)19(23)9-3-2-4-10-19/h5-8,18,23H,2-4,9-15H2,1H3 | Reactome pathway
KEGG
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Similars
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PubMed
| 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50307460
((1S,2R)-1-(7-Fluoro-3,3-dimethyl-2,3-dihydro-1H-in...)Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2cccc(F)c12)c1cccc(F)c1 |r| Show InChI InChI=1S/C20H24F2N2O/c1-20(2)12-24(19-15(20)8-5-9-16(19)22)18(17(25)11-23-3)13-6-4-7-14(21)10-13/h4-10,17-18,23,25H,11-12H2,1-3H3/t17-,18+/m1/s1 | Reactome pathway
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| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 2051-62 (2010)
Article DOI: 10.1021/jm901559e
BindingDB Entry DOI: 10.7270/Q21J99VS |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50307459
((1S,2R)-1-(7-Fluoro-3,3-dimethyl-2,3-dihydro-1H-in...)Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2cccc(F)c12)c1ccccc1 |r| Show InChI InChI=1S/C20H25FN2O/c1-20(2)13-23(19-15(20)10-7-11-16(19)21)18(17(24)12-22-3)14-8-5-4-6-9-14/h4-11,17-18,22,24H,12-13H2,1-3H3/t17-,18+/m1/s1 | Reactome pathway
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PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 2051-62 (2010)
Article DOI: 10.1021/jm901559e
BindingDB Entry DOI: 10.7270/Q21J99VS |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50307469
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-(5-me...)Show SMILES CNC[C@@H](O)[C@@H](N1CCc2cc(C)ccc12)c1cccc(F)c1 |r| Show InChI InChI=1S/C19H23FN2O/c1-13-6-7-17-14(10-13)8-9-22(17)19(18(23)12-21-2)15-4-3-5-16(20)11-15/h3-7,10-11,18-19,21,23H,8-9,12H2,1-2H3/t18-,19+/m1/s1 | Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 2051-62 (2010)
Article DOI: 10.1021/jm901559e
BindingDB Entry DOI: 10.7270/Q21J99VS |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50307457
((1S,2R)-1-(3,3-Dimethyl-2,3-dihydro-1H-indol-1-yl)...)Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2ccccc12)c1cccc(F)c1 |r| Show InChI InChI=1S/C20H25FN2O/c1-20(2)13-23(17-10-5-4-9-16(17)20)19(18(24)12-22-3)14-7-6-8-15(21)11-14/h4-11,18-19,22,24H,12-13H2,1-3H3/t18-,19+/m1/s1 | Reactome pathway
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 2051-62 (2010)
Article DOI: 10.1021/jm901559e
BindingDB Entry DOI: 10.7270/Q21J99VS |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50307459
((1S,2R)-1-(7-Fluoro-3,3-dimethyl-2,3-dihydro-1H-in...)Show SMILES CNC[C@@H](O)[C@@H](N1CC(C)(C)c2cccc(F)c12)c1ccccc1 |r| Show InChI InChI=1S/C20H25FN2O/c1-20(2)13-23(19-15(20)10-7-11-16(19)21)18(17(24)12-22-3)14-8-5-4-6-9-14/h4-11,17-18,22,24H,12-13H2,1-3H3/t17-,18+/m1/s1 | Reactome pathway
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| CHEMBL
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PC sid
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PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 2051-62 (2010)
Article DOI: 10.1021/jm901559e
BindingDB Entry DOI: 10.7270/Q21J99VS |
More data for this
Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50307470
((1S,2R)-1-(5-Chloro-2,3-dihydro-1H-indol-1-yl)-1-(...)Show SMILES CNC[C@@H](O)[C@@H](N1CCc2cc(Cl)ccc12)c1cccc(F)c1 |r| Show InChI InChI=1S/C18H20ClFN2O/c1-21-11-17(23)18(13-3-2-4-15(20)10-13)22-8-7-12-9-14(19)5-6-16(12)22/h2-6,9-10,17-18,21,23H,7-8,11H2,1H3/t17-,18+/m1/s1 | PDB
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| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of serotonin uptake at human SERT expressed in human JAR cells |
J Med Chem 53: 2051-62 (2010)
Article DOI: 10.1021/jm901559e
BindingDB Entry DOI: 10.7270/Q21J99VS |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50124566
((R)-2-((R)-(2-ethoxyphenoxy)(phenyl)methyl)morphol...)Show InChI InChI=1S/C19H23NO3/c1-2-21-16-10-6-7-11-17(16)23-19(15-8-4-3-5-9-15)18-14-20-12-13-22-18/h3-11,18-20H,2,12-14H2,1H3 | Reactome pathway
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| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 2051-62 (2010)
Article DOI: 10.1021/jm901559e
BindingDB Entry DOI: 10.7270/Q21J99VS |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | Reactome pathway
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Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Displacement of [3H]nisoxetine from human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 2051-62 (2010)
Article DOI: 10.1021/jm901559e
BindingDB Entry DOI: 10.7270/Q21J99VS |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | Reactome pathway
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Article
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| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human norepinephrine transporter expressed in MDCK-Net6 cells |
J Med Chem 51: 4038-49 (2008)
Article DOI: 10.1021/jm8002262
BindingDB Entry DOI: 10.7270/Q2TB16PB |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM35229
(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)Show InChI InChI=1S/C18H22N2/c1-19-13-6-14-20-17-9-4-2-7-15(17)11-12-16-8-3-5-10-18(16)20/h2-5,7-10,19H,6,11-14H2,1H3 | Reactome pathway
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Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 2051-62 (2010)
Article DOI: 10.1021/jm901559e
BindingDB Entry DOI: 10.7270/Q21J99VS |
More data for this
Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50307466
((1S,2R)-1-(3-Fluorophenyl)-3-(methylamino)-1-[(3R)...)Show SMILES CNC[C@@H](O)[C@@H](N1C[C@H](C)c2ccccc12)c1cccc(F)c1 |r| Show InChI InChI=1S/C19H23FN2O/c1-13-12-22(17-9-4-3-8-16(13)17)19(18(23)11-21-2)14-6-5-7-15(20)10-14/h3-10,13,18-19,21,23H,11-12H2,1-2H3/t13-,18+,19-/m0/s1 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of norepinephrine uptake at human NET expressed in MDCK-Net6 cells |
J Med Chem 53: 2051-62 (2010)
Article DOI: 10.1021/jm901559e
BindingDB Entry DOI: 10.7270/Q21J99VS |
More data for this
Ligand-Target Pair | |
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