Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM92649 (EPZ004777) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 0.300 | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. | Assay Description Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay. | Chem Biol Drug Des 80: 971-80 (2012) Article DOI: 10.1111/cbdd.12050 BindingDB Entry DOI: 10.7270/Q2Z89B12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM378462 (6-chloro-2-oxo-N-((1R,3r,5S)-8-(((1-(4,4,4-trifluo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. Curated by ChEMBL | Assay Description Non-competitive inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using varyin... | ACS Med Chem Lett 7: 134-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00272 BindingDB Entry DOI: 10.7270/Q2NG4TPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM378462 (6-chloro-2-oxo-N-((1R,3r,5S)-8-(((1-(4,4,4-trifluo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. Curated by ChEMBL | Assay Description Non-competitive inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using fixed ... | ACS Med Chem Lett 7: 134-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00272 BindingDB Entry DOI: 10.7270/Q2NG4TPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM378459 (N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)su...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. Curated by ChEMBL | Assay Description Non-competitive inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using varyin... | ACS Med Chem Lett 7: 134-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00272 BindingDB Entry DOI: 10.7270/Q2NG4TPR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Insulin receptor (Homo sapiens (Human)) | BDBM50256480 (CHEMBL466397 | N-(2,6-difluorophenyl)-5-(3-(2-(5-e...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity to insulin receptor by liquid scintillation counting | Bioorg Med Chem Lett 19: 1004-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.058 BindingDB Entry DOI: 10.7270/Q24T6J8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin-like growth factor 1 receptor (Homo sapiens (Human)) | BDBM50256480 (CHEMBL466397 | N-(2,6-difluorophenyl)-5-(3-(2-(5-e...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity to IGF1R by liquid scintillation counting | Bioorg Med Chem Lett 19: 1004-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.058 BindingDB Entry DOI: 10.7270/Q24T6J8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin receptor (Homo sapiens (Human)) | BDBM50256478 (CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity to insulin receptor by liquid scintillation counting | Bioorg Med Chem Lett 19: 1004-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.058 BindingDB Entry DOI: 10.7270/Q24T6J8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM92648 (EPZ004450) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. | Assay Description Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay. | Chem Biol Drug Des 80: 971-80 (2012) Article DOI: 10.1111/cbdd.12050 BindingDB Entry DOI: 10.7270/Q2Z89B12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM378459 (N-((1R,3r,5S)-8-((4-(benzylamino)piperidin-1-yl)su...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. Curated by ChEMBL | Assay Description Mixed type inhibition of full length N-terminal His-tagged SMYD3 (1 to 428 residues) (unknown origin) expressed in Escherichia coli using fixed N-ter... | ACS Med Chem Lett 7: 134-8 (2016) Article DOI: 10.1021/acsmedchemlett.5b00272 BindingDB Entry DOI: 10.7270/Q2NG4TPR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Insulin-like growth factor 1 receptor (Homo sapiens (Human)) | BDBM50256478 (CHEMBL507714 | N-(2,6-difluorophenyl)-3-(3-(2-(2-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Binding affinity to IGF1R by liquid scintillation counting | Bioorg Med Chem Lett 19: 1004-8 (2009) Article DOI: 10.1016/j.bmcl.2008.11.058 BindingDB Entry DOI: 10.7270/Q24T6J8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM92647 (EPZ003696) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. | Assay Description Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay. | Chem Biol Drug Des 80: 971-80 (2012) Article DOI: 10.1111/cbdd.12050 BindingDB Entry DOI: 10.7270/Q2Z89B12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM92642 (SAH) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | 320 | n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. | Assay Description Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay. | Chem Biol Drug Des 80: 971-80 (2012) Article DOI: 10.1111/cbdd.12050 BindingDB Entry DOI: 10.7270/Q2Z89B12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM92646 (EPZ003647) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 845 | n/a | n/a | 167 | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. | Assay Description Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay. | Chem Biol Drug Des 80: 971-80 (2012) Article DOI: 10.1111/cbdd.12050 BindingDB Entry DOI: 10.7270/Q2Z89B12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM92644 (EPZ002446) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. | Assay Description Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay. | Chem Biol Drug Des 80: 971-80 (2012) Article DOI: 10.1111/cbdd.12050 BindingDB Entry DOI: 10.7270/Q2Z89B12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM92645 (EPZ003144) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. | Assay Description Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay. | Chem Biol Drug Des 80: 971-80 (2012) Article DOI: 10.1111/cbdd.12050 BindingDB Entry DOI: 10.7270/Q2Z89B12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM92643 (EPZ000004) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme Inc. | Assay Description Assay of DOT1L enzymatic activity were performed under balanced conditions using a radiometric assay. | Chem Biol Drug Des 80: 971-80 (2012) Article DOI: 10.1111/cbdd.12050 BindingDB Entry DOI: 10.7270/Q2Z89B12 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM433063 (5-cyclopropyl-N-((1R,3R,5S)-8-(((1S,4S)- 4-((2- hy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM378442 (N-((1R,3R,5S)-8-(((1r,4R)-4-aminocyclohexyl)sulfon...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
ENSCMu | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | Bioorg Med Chem 14: 7241-57 (2006) BindingDB Entry DOI: 10.7270/Q2DJ5HX2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM378443 (N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.490 | n/a | n/a | n/a | n/a | n/a | n/a |
ENSCMu | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | Bioorg Med Chem 14: 7241-57 (2006) BindingDB Entry DOI: 10.7270/Q2DJ5HX2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human)) | BDBM172085 (US10155002, Compound 91 | US11052093, Compound 91 ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US10155002 (2018) BindingDB Entry DOI: 10.7270/Q2KS6TM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human)) | BDBM172085 (US10155002, Compound 91 | US11052093, Compound 91 ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SB48WP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human)) | BDBM172085 (US10155002, Compound 91 | US11052093, Compound 91 ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | 25 |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US9090562 (2015) BindingDB Entry DOI: 10.7270/Q2057DPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM432825 (5-cyclopropyl-N-((1R,3r,5S)-8-(((1-(4,4,4- trifluo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM378444 (N-((1R,3r,5S)-8-(((1-methylpiperidin-4-yl)methyl)s...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
ENSCMu | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | Bioorg Med Chem 14: 7241-57 (2006) BindingDB Entry DOI: 10.7270/Q2DJ5HX2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM378445 (N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.680 | n/a | n/a | n/a | n/a | n/a | n/a |
ENSCMu | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | Bioorg Med Chem 14: 7241-57 (2006) BindingDB Entry DOI: 10.7270/Q2DJ5HX2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM433064 (5-cyclopropyl-N-((1R,3R,5S)-8-(((1R,4R)- 4-((2- hy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human)) | BDBM172163 (US10155002, Compound 171 | US11052093, Compound 17...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | 25 |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US9090562 (2015) BindingDB Entry DOI: 10.7270/Q2057DPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human)) | BDBM172163 (US10155002, Compound 171 | US11052093, Compound 17...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US10155002 (2018) BindingDB Entry DOI: 10.7270/Q2KS6TM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM433065 (5-cyclopropyl-N-((1R,3r,5S)-8-((7- phenethyl-2,7-d...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human)) | BDBM172163 (US10155002, Compound 171 | US11052093, Compound 17...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SB48WP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 [A677G] (Homo sapiens (Human)) | BDBM172176 (EPZ009161 | US10155002, Compound 184 | US11052093,...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat... | US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 [A677G] (Homo sapiens (Human)) | BDBM190202 (EPZ008337 | US9175331, 32) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat... | US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM432826 (N-((2S,4S)-1-((4-aminopiperidin-1- yl)sulfonyl)-2-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM432822 (N-((1R,3r,5S)-8-((4- aminocyclohexyl)sulfonyl)-8- ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human)) | BDBM28206 (3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-(5,6-dimethoxy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | 7.2 | 22 |
GSK | Assay Description The compound inhibitory activity was determined by incubation with purified PLK enzyme and biotinylated peptide substrate in the presence ATP/[gamma-... | Bioorg Med Chem Lett 19: 1694-7 (2009) Article DOI: 10.1016/j.bmcl.2009.01.094 BindingDB Entry DOI: 10.7270/Q2319T6X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM378446 (N-((1R,3r,5S)-8-((4-aminopiperidin-1-yl)sulfonyl)-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.810 | n/a | n/a | n/a | n/a | n/a | n/a |
ENSCMu | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | Bioorg Med Chem 14: 7241-57 (2006) BindingDB Entry DOI: 10.7270/Q2DJ5HX2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human)) | BDBM172087 (US10155002, Compound 93 | US11052093, Compound 93 ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.870 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SB48WP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human)) | BDBM172087 (US10155002, Compound 93 | US11052093, Compound 93 ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.870 | n/a | n/a | n/a | n/a | n/a | 25 |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US9090562 (2015) BindingDB Entry DOI: 10.7270/Q2057DPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 [Y641F] (Homo sapiens (Human)) | BDBM172087 (US10155002, Compound 93 | US11052093, Compound 93 ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.870 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US10155002 (2018) BindingDB Entry DOI: 10.7270/Q2KS6TM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM433066 (5-cyclopropyl-N-((1R,3r,5S)-8-(((1- methylpiperidi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.880 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM432829 (N-((1R,3r,5S)-8-((4-aminopiperidin-1- yl)sulfonyl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM378447 (N-((2S,4S)-1-((4-aminopiperidin-1-yl)sulfonyl)-2-m...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
ENSCMu | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | Bioorg Med Chem 14: 7241-57 (2006) BindingDB Entry DOI: 10.7270/Q2DJ5HX2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM432827 (5-cyclopropyl-N-((2S,4S)-2-methyl-1- (((1-phenethy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM432828 (5-cyclopropyl-N-((1R,3r,5S)-8-(((1-(2- hydroxyethy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM172176 (EPZ009161 | US10155002, Compound 184 | US11052093,...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat... | US Patent US9175331 (2015) BindingDB Entry DOI: 10.7270/Q2ZW1JQP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM172176 (EPZ009161 | US10155002, Compound 184 | US11052093,...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | 25 |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US9090562 (2015) BindingDB Entry DOI: 10.7270/Q2057DPX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM172176 (EPZ009161 | US10155002, Compound 184 | US11052093,...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | Citation and Details BindingDB Entry DOI: 10.7270/Q2SB48WP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM172176 (EPZ009161 | US10155002, Compound 184 | US11052093,...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.920 | n/a | n/a | n/a | n/a | n/a | n/a |
Epizyme, Inc. US Patent | Assay Description The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use.... | US Patent US10155002 (2018) BindingDB Entry DOI: 10.7270/Q2KS6TM3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM433067 (5-cyclopropyl-N-((1R,3R,5S)-8-(((1s,4S)- 4-(dimeth...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase SMYD3 (Homo sapiens (Human)) | BDBM433068 (N-((2S,4S)-1-((((1S,3S)-3- aminocyclopentyl)methyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a |
EPIZYME, INC. US Patent | Assay Description The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use.... | US Patent US10577363 (2020) BindingDB Entry DOI: 10.7270/Q2BZ68G7 | |||||||||||
More data for this Ligand-Target Pair |
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