Compile Data Set for Download or QSAR

Found 1399 hits with Last Name = 'laforteza' and Initial = 'bn'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Monoglyceride lipase (Homo sapiens (Human))	BDBM50582221 (CHEMBL5090028 | US11708359, Example 60) Show SMILES CC(C)(C)c1cccc(c1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:21.31,19.21,(59.02,-28.21,;59.02,-26.67,;60.35,-25.91,;60.34,-27.44,;57.69,-25.9,;56.35,-26.67,;55.02,-25.89,;55.03,-24.36,;56.37,-23.61,;57.69,-24.37,;56.38,-22.07,;57.7,-21.3,;56.37,-20.54,;55.04,-19.76,;53.72,-20.54,;53.7,-22.08,;55.03,-22.85,;52.38,-19.77,;52.38,-18.23,;51.05,-20.54,;50.65,-22.03,;49.16,-21.63,;49.56,-20.14,;48.84,-23.14,;47.3,-23.3,;46.68,-21.89,;45.17,-21.57,;47.82,-20.86,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.00700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2FRS
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311805 (7-(4-Fluorophenyl)-8-(7-chloro-1H-indazol-5-yl)-2-...) Show SMILES Fc1ccc(cc1)-c1ccn2nc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C20H10ClF4N5/c21-15-8-11(7-12-9-26-28-17(12)15)16-14(10-1-3-13(22)4-2-10)5-6-30-18(16)27-19(29-30)20(23,24)25/h1-9H,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288255 (7-Chloro-5-(2-isopropyl-6-(trifluoromethyl)pyrazol...) Show SMILES CC(C)c1cc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C18H14ClF3N4/c1-9(2)15-7-12-3-4-13(18(20,21)22)17(26(12)25-15)10-5-11-8-23-24-16(11)14(19)6-10/h3-9H,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288248 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES FC(F)(F)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F Show InChI InChI=1S/C17H8ClF6N3O/c18-11-4-8(3-7-5-13(28)25-14(7)11)15-10(16(19,20)21)2-1-9-6-12(17(22,23)24)26-27(9)15/h1-4,6H,5H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0130	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288254 (5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...) Show SMILES CC(C)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(Cl)c3)n2n1)C(F)(F)F Show InChI InChI=1S/C19H15ClF3N3O/c1-9(2)15-8-12-3-4-13(19(21,22)23)18(26(12)25-15)11-5-10-7-16(27)24-17(10)14(20)6-11/h3-6,8-9H,7H2,1-2H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0130	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288253 (5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...) Show SMILES CC(C)c1cc2ccc(c(-c3cc4CC(=O)Nc4c(C)c3)n2n1)C(F)(F)F Show InChI InChI=1S/C20H18F3N3O/c1-10(2)16-9-14-4-5-15(20(21,22)23)19(26(14)25-16)13-6-11(3)18-12(7-13)8-17(27)24-18/h4-7,9-10H,8H2,1-3H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288247 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C18H11F6N3O/c1-8-4-10(5-9-6-14(28)25-15(8)9)16-12(17(19,20)21)3-2-11-7-13(18(22,23)24)26-27(11)16/h2-5,7H,6H2,1H3,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288245 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES FC(F)(F)c1cc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C16H7ClF6N4/c17-11-4-7(3-8-6-24-25-13(8)11)14-10(15(18,19)20)2-1-9-5-12(16(21,22)23)26-27(9)14/h1-6H,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311771 (2-Cyclopentyl-7-(4-fluorophenyl)-8-(7-methyl-1H-in...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CCCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H22FN5/c1-15-12-18(13-19-14-27-29-23(15)19)22-21(16-6-8-20(26)9-7-16)10-11-31-25(22)28-24(30-31)17-4-2-3-5-17/h6-14,17H,2-5H2,1H3,(H,27,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288302 (7-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-2-...) Show SMILES FC(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C16H8ClF5N4/c17-11-4-7(3-8-6-23-24-13(8)11)14-10(15(18)19)2-1-9-5-12(16(20,21)22)25-26(9)14/h1-6,15H,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288246 (5-(2,6-Bis(trifluoromethyl)pyrazolo[1,5-a]pyridin-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C17H10F6N4/c1-8-4-9(5-10-7-24-25-14(8)10)15-12(16(18,19)20)3-2-11-6-13(17(21,22)23)26-27(11)15/h2-7H,1H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0160	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM609871 ((rac)-(2s,4s)-2-(6-(4-(tert-Butyl)phenyl)-3-azabic...) Show SMILES CC(C)(C)c1ccc(cc1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:19.21,wD:21.24,(5.59,-5.26,;6.36,-3.93,;7.9,-3.93,;7.13,-5.26,;5.59,-2.59,;4.05,-2.59,;3.28,-1.26,;4.05,.08,;5.59,.08,;6.36,-1.26,;3.28,1.41,;4.62,2.18,;3.28,2.95,;1.95,3.72,;.62,2.95,;.62,1.41,;1.95,.64,;-.72,3.72,;-.72,5.26,;-2.05,2.95,;-2.45,1.46,;-3.94,1.86,;-3.54,3.35,;-4.1,.33,;-5.6,.01,;-6.37,1.34,;-7.9,1.5,;-5.34,2.49,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0190	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2FRS
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292056 (2-Cyclobutyl-3-(7-methyl-1H-indazol-5-yl)-5-(trifl...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1 Show InChI InChI=1S/C19H16F3N5/c1-10-7-11(8-12-9-23-25-16(10)12)18-17-14(26-27(18)13-3-2-4-13)5-6-15(24-17)19(20,21)22/h5-9,13H,2-4H2,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292057 (3-(7-Chloro-1H-indazol-5-yl)-2-cyclobutyl-5-(trifl...) Show SMILES FC(F)(F)c1ccc2nn(C3CCC3)c(-c3cc(Cl)c4[nH]ncc4c3)c2n1 Show InChI InChI=1S/C18H13ClF3N5/c19-12-7-9(6-10-8-23-25-15(10)12)17-16-13(26-27(17)11-2-1-3-11)4-5-14(24-16)18(20,21)22/h4-8,11H,1-3H2,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288250 (5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...) Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc2CC(=O)Nc2c(Cl)c1)C1CC1 Show InChI InChI=1S/C19H13ClF3N3O/c20-14-6-11(5-10-7-16(27)24-17(10)14)18-13(19(21,22)23)4-3-12-8-15(9-1-2-9)25-26(12)18/h3-6,8-9H,1-2,7H2,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0200	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM50582222 (CHEMBL5074982 | US11708359, Example 71) Show SMILES CC1(CC1)c1cccc(c1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:21.32,19.22,(81.16,-28.5,;81.16,-26.95,;81.56,-25.46,;82.65,-26.55,;79.83,-26.18,;78.5,-26.95,;77.17,-26.18,;77.18,-24.64,;78.52,-23.89,;79.83,-24.65,;78.52,-22.35,;79.85,-21.58,;78.52,-20.82,;77.18,-20.04,;75.86,-20.82,;75.85,-22.36,;77.18,-23.13,;74.53,-20.05,;74.53,-18.51,;73.2,-20.82,;72.8,-22.31,;71.31,-21.91,;71.71,-20.42,;70.99,-23.42,;69.45,-23.58,;68.82,-22.17,;67.31,-21.85,;69.97,-21.14,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0240	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2FRS
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311766 (2-Cyclobutyl-7-(4-fluorophenyl)-8-(7-methyl-1H-ind...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CCC1)-c1ccc(F)cc1 Show InChI InChI=1S/C24H20FN5/c1-14-11-17(12-18-13-26-28-22(14)18)21-20(15-5-7-19(25)8-6-15)9-10-30-24(21)27-23(29-30)16-3-2-4-16/h5-13,16H,2-4H2,1H3,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288303 (6-(Difluoromethyl)-7-(7-methyl-1H-indazol-5-yl)-2-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)F Show InChI InChI=1S/C17H11F5N4/c1-8-4-9(5-10-7-23-24-14(8)10)15-12(16(18)19)3-2-11-6-13(17(20,21)22)25-26(11)15/h2-7,16H,1H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311848 (8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(triflu...) Show SMILES CC(C)c1cn2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C18H14ClF3N4/c1-9(2)14-8-26-4-3-12(18(20,21)22)15(17(26)24-14)10-5-11-7-23-25-16(11)13(19)6-10/h3-9H,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0250	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311806 (7-(4-Fluorophenyl)-8-(7-methyl-1H-indazol-5-yl)-2-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C21H13F4N5/c1-11-8-13(9-14-10-26-28-18(11)14)17-16(12-2-4-15(22)5-3-12)6-7-30-19(17)27-20(29-30)21(23,24)25/h2-10H,1H3,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311808 (2-(Difluoromethyl)-7-(4-fluorophenyl)-8-(7-methyl-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C21H14F3N5/c1-11-8-13(9-14-10-25-27-18(11)14)17-16(12-2-4-15(22)5-3-12)6-7-29-21(17)26-20(28-29)19(23)24/h2-10,19H,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292055 (7-Chloro-5-(2-cyclobutyl-5-(trifluoromethyl)-2H-py...) Show SMILES FC(F)(F)c1ccc2nn(C3CCC3)c(-c3cc4CC(=O)Nc4c(Cl)c3)c2n1 Show InChI InChI=1S/C19H14ClF3N4O/c20-12-7-10(6-9-8-15(28)25-16(9)12)18-17-13(26-27(18)11-2-1-3-11)4-5-14(24-17)19(21,22)23/h4-7,11H,1-3,8H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311811 (7-Isopropyl-8-(7-methyl-1H-indazol-5-yl)-2-(triflu...) Show SMILES CC(C)c1ccn2nc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C18H16F3N5/c1-9(2)13-4-5-26-16(23-17(25-26)18(19,20)21)14(13)11-6-10(3)15-12(7-11)8-22-24-15/h4-9H,1-3H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0320	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM609880 ((rac)-(2s,4s)-2-(6-(4-(1-Methylcyclopropyl)phenyl)...) Show SMILES CC1(CC1)c1ccc(cc1)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:19.22,wD:21.25,(5.7,-5.26,;6.47,-3.93,;7.8,-4.7,;7.8,-3.16,;5.7,-2.59,;4.16,-2.59,;3.39,-1.26,;4.16,.08,;5.7,.08,;6.47,-1.26,;3.39,1.41,;4.72,2.18,;3.39,2.95,;2.05,3.72,;.72,2.95,;.72,1.41,;2.05,.64,;-.61,3.72,;-.61,5.26,;-1.95,2.95,;-2.35,1.46,;-3.83,1.86,;-3.43,3.35,;-3.99,.33,;-5.5,.01,;-6.27,1.34,;-7.8,1.5,;-5.24,2.49,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0340	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2FRS
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288237 (6-(4-Fluorophenyl)-5-(7-methyl-1H-indazol-5-yl)-2-...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C21H13F4N5/c1-11-8-13(9-14-10-26-28-18(11)14)19-16(12-2-4-15(22)5-3-12)6-7-17-27-20(21(23,24)25)29-30(17)19/h2-10H,1H3,(H,26,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0400	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311847 (5-(2,7-Bis(trifluoromethyl)imidazo[1,2-a]pyridin-8...) Show SMILES FC(F)(F)c1cn2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C16H7ClF6N4/c17-10-4-7(3-8-5-24-26-13(8)10)12-9(15(18,19)20)1-2-27-6-11(16(21,22)23)25-14(12)27/h1-6H,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288301 (5-[6-(Difluoromethyl)-2-(trifluoromethyl)pyrazolo[...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C(F)(F)F)C(F)F Show InChI InChI=1S/C18H12F5N3O/c1-8-4-10(5-9-6-14(27)24-15(8)9)16-12(17(19)20)3-2-11-7-13(18(21,22)23)25-26(11)16/h2-5,7,17H,6H2,1H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288304 (5-[6-(Difluoromethyl)-4-methyl-2-(trifluoromethyl)...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(cc(C)c2cc(nn12)C(F)(F)F)C(F)F Show InChI InChI=1S/C19H14F5N3O/c1-8-4-12(18(20)21)17(27-13(8)7-14(26-27)19(22,23)24)11-3-9(2)16-10(5-11)6-15(28)25-16/h3-5,7,18H,6H2,1-2H3,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288251 (5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccc2cc(nn12)C1CC1)C(F)(F)F Show InChI InChI=1S/C19H15F3N4/c1-10-6-12(7-13-9-23-24-17(10)13)18-15(19(20,21)22)5-4-14-8-16(11-2-3-11)25-26(14)18/h4-9,11H,2-3H2,1H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288235 (5-(7-Chloro-1H-indazol-5-yl)-6-(1,1-difluoroethyl)...) Show SMILES CC(F)(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C16H9ClF5N5/c1-15(18,19)9-2-3-11-24-14(16(20,21)22)26-27(11)13(9)7-4-8-6-23-25-12(8)10(17)5-7/h2-6H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288249 (5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C1CC1)C(F)(F)F Show InChI InChI=1S/C20H16F3N3O/c1-10-6-13(7-12-8-17(27)24-18(10)12)19-15(20(21,22)23)5-4-14-9-16(11-2-3-11)25-26(14)19/h4-7,9,11H,2-3,8H2,1H3,(H,24,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292054 (5-(2-Cyclobutyl-5-(trifluoromethyl)-2H-pyrazolo[4,...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1n(nc2ccc(nc12)C(F)(F)F)C1CCC1 Show InChI InChI=1S/C20H17F3N4O/c1-10-7-12(8-11-9-16(28)25-17(10)11)19-18-14(26-27(19)13-3-2-4-13)5-6-15(24-18)20(21,22)23/h5-8,13H,2-4,9H2,1H3,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0500	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288252 (7-Chloro-5-(2-cyclopropyl-6-(trifluoromethyl)pyraz...) Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1 Show InChI InChI=1S/C18H12ClF3N4/c19-14-6-10(5-11-8-23-24-16(11)14)17-13(18(20,21)22)4-3-12-7-15(9-1-2-9)25-26(12)17/h3-9H,1-2H2,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292053 (3-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-5-(triflu...) Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)26-16(9-5-10-7-22-24-14(10)11(18)6-9)15-12(25-26)3-4-13(23-15)17(19,20)21/h3-8H,1-2H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288252 (7-Chloro-5-(2-cyclopropyl-6-(trifluoromethyl)pyraz...) Show SMILES FC(F)(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C1CC1 Show InChI InChI=1S/C18H12ClF3N4/c19-14-6-10(5-11-8-23-24-16(11)14)17-13(18(20,21)22)4-3-12-7-15(9-1-2-9)25-26(12)17/h3-9H,1-2H2,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288239 (5-(6-(4-Fluorophenyl)-2-(trifluoromethyl)-[1,2,4]t...) Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C22H14F4N4O/c1-11-8-14(9-13-10-18(31)28-19(11)13)20-16(12-2-4-15(23)5-3-12)6-7-17-27-21(22(24,25)26)29-30(17)20/h2-9H,10H2,1H3,(H,28,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288189 (5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-6-...) Show SMILES FC(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C15H7ClF5N5/c16-9-4-6(3-7-5-22-24-11(7)9)12-8(15(19,20)21)1-2-10-23-14(13(17)18)25-26(10)12/h1-5,13H,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0630	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM609878 ((rac)-(2s,4s)-2-(6-(3-Chloro-4-methylphenyl)-3- az...) Show SMILES Cc1ccc(cc1Cl)C12CC1CN(CC2)C(=O)[C@H]1C[C@@]2(C1)COC(=O)N2 |r,wU:17.19,wD:19.22,(6.36,-4.59,;5.59,-3.26,;4.05,-3.26,;3.28,-1.93,;4.05,-.59,;5.59,-.59,;6.36,-1.93,;7.9,-1.93,;3.28,.74,;4.62,1.51,;3.28,2.28,;1.95,3.05,;.62,2.28,;.62,.74,;1.95,-.03,;-.72,3.05,;-.72,4.59,;-2.05,2.28,;-2.45,.79,;-3.94,1.19,;-3.54,2.68,;-4.1,-.34,;-5.6,-.66,;-6.37,.68,;-7.9,.84,;-5.34,1.82,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.0750	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2JM2FRS
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288256 (5-(2-Isopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]p...) Show SMILES CC(C)c1cc2ccc(c(-c3cc(C)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C19H17F3N4/c1-10(2)16-8-14-4-5-15(19(20,21)22)18(26(14)25-16)12-6-11(3)17-13(7-12)9-23-24-17/h4-10H,1-3H3,(H,23,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288183 (5-(7-Chloro-1H-indazol-5-yl)-2,6-bis(trifluorometh...) Show SMILES FC(F)(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C15H6ClF6N5/c16-9-4-6(3-7-5-23-25-11(7)9)12-8(14(17,18)19)1-2-10-24-13(15(20,21)22)26-27(10)12/h1-5H,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288218 (5-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-6-(triflu...) Show SMILES CC(C)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)16-23-13-4-3-11(17(19,20)21)15(26(13)25-16)9-5-10-7-22-24-14(10)12(18)6-9/h3-8H,1-2H3,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311810 (2-Cyclopropyl-7-(4-fluorophenyl)-8-(7-methyl-1H-in...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C1CC1)-c1ccc(F)cc1 Show InChI InChI=1S/C23H18FN5/c1-13-10-16(11-17-12-25-27-21(13)17)20-19(14-4-6-18(24)7-5-14)8-9-29-23(20)26-22(28-29)15-2-3-15/h4-12,15H,2-3H2,1H3,(H,25,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311768 (7-Cyclopentyl-8-(7-methyl-1H-indazol-5-yl)-2-(trif...) Show SMILES Cc1cc(cc2cn[nH]c12)-c1c(ccn2nc(nc12)C(F)(F)F)C1CCCC1 Show InChI InChI=1S/C20H18F3N5/c1-11-8-13(9-14-10-24-26-17(11)14)16-15(12-4-2-3-5-12)6-7-28-18(16)25-19(27-28)20(21,22)23/h6-10,12H,2-5H2,1H3,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0790	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Monoglyceride lipase (Homo sapiens (Human))	BDBM630876 ((7-((3,6-Dimethyl-5-(trifluoromethyl)pyridin-2-yl)...) Show SMILES Cc1cc(c(C)nc1OC1CCC2(CN(C2)C(=O)[C@H]2C[C@@](C)(O)C2)CC1)C(F)(F)F |r,wU:20.23,18.19,wD:20.22,(5.29,-3.62,;5.29,-2.08,;6.62,-1.31,;6.62,.23,;5.29,1,;5.29,2.54,;3.95,.23,;3.95,-1.31,;2.62,-2.08,;1.29,-1.31,;-.05,-2.08,;-1.38,-1.31,;-1.38,.23,;-2.87,-.17,;-3.27,1.31,;-1.78,1.71,;-4.6,2.08,;-4.6,3.62,;-5.93,1.31,;-6.33,-.17,;-7.82,.23,;-8.22,-1.26,;-9.29,.64,;-7.42,1.71,;-.05,1,;1.29,.23,;7.95,1,;7.95,2.54,;9.29,.23,;9.29,1.77,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311849 (2-Isopropyl-8-(7-methyl-1H-indazol-5-yl)-7-(triflu...) Show SMILES CC(C)c1cn2ccc(c(-c3cc(C)c4[nH]ncc4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C19H17F3N4/c1-10(2)15-9-26-5-4-14(19(20,21)22)16(18(26)24-15)12-6-11(3)17-13(7-12)8-23-25-17/h4-10H,1-3H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM311828 (8-(7-Chloro-1H-indazol-5-yl)-2-isopropyl-7-(triflu...) Show SMILES CC(C)c1cn2cnc(c(-c3cc(Cl)c4[nH]ncc4c3)c2n1)C(F)(F)F Show InChI InChI=1S/C17H13ClF3N5/c1-8(2)12-6-26-7-22-15(17(19,20)21)13(16(26)24-12)9-3-10-5-23-25-14(10)11(18)4-9/h3-8H,1-2H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description An in vitro assay was used to determine the potency of test compounds as inhibitors of the glutamate response of the channel formed by GluA1o-γ8...				US Patent US10155769 (2018) BindingDB Entry DOI: 10.7270/Q2SB47TC
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288224 (5-(7-Chloro-1H-indazol-5-yl)-2-(1,1-difluoroethyl)...) Show SMILES CC(F)(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F Show InChI InChI=1S/C16H9ClF5N5/c1-15(18,19)14-24-11-3-2-9(16(20,21)22)13(27(11)26-14)7-4-8-6-23-25-12(8)10(17)5-7/h2-6H,1H3,(H,23,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288307 (7-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-4-...) Show SMILES Cc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(cc12)C(F)(F)F Show InChI InChI=1S/C17H10ClF5N4/c1-7-2-10(16(19)20)15(27-12(7)5-13(26-27)17(21,22)23)8-3-9-6-24-25-14(9)11(18)4-8/h2-6,16H,1H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-2 subunit (Homo sapiens (Human))	BDBM292061 (5-(Difluoromethyl)-2-isopropyl-3-(7-methyl-1H-inda...) Show SMILES CC(C)n1nc2ccc(nc2c1-c1cc(C)c2[nH]ncc2c1)C(F)F Show InChI InChI=1S/C18H17F2N5/c1-9(2)25-17(11-6-10(3)15-12(7-11)8-21-23-15)16-13(24-25)4-5-14(22-16)18(19)20/h4-9,18H,1-3H3,(H,21,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description Cell expressing the GRIA1o-CACNG8 fusion construct were grown in a monolayer in 96- or 384-well microtiter plates. They were washed with assay buffer...				US Patent US10100045 (2018) BindingDB Entry DOI: 10.7270/Q2MW2K56
					More data for this Ligand-Target Pair
Voltage-dependent calcium channel gamma-8 subunit (Homo sapiens (Human))	BDBM288198 (5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-2-...) Show SMILES FC(F)c1ccc2nc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F Show InChI InChI=1S/C15H7ClF5N5/c16-9-4-6(3-7-5-22-24-11(7)9)12-8(13(17)18)1-2-10-23-14(15(19,20)21)25-26(10)12/h1-5,13H,(H,22,24)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	7.4	n/a
Janssen Pharmaceutica NV US Patent					Assay Description This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...				US Patent US10087185 (2018) BindingDB Entry DOI: 10.7270/Q2QZ2D0H
					More data for this Ligand-Target Pair

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