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Compile Data Set for Download or QSAR

Found 68 hits with Last Name = 'lahrichi' and Initial = 'sl'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085734
PNG
(CHEMBL407628 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@@H](Cc3cnc[nH]3)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C62H87ClN20O14/c1-5-38(73-33(4)84)53(89)79-43(24-34-12-14-36(63)15-13-34)57(93)80-44(25-35-9-6-19-67-28-35)58(94)81-46-27-50(86)71-30-47(51(64)87)82-60(96)48-11-8-22-83(48)61(97)41-18-21-69-52(88)45(26-37-29-68-31-72-37)74-49(85)17-16-40(76-59(46)95)55(91)75-39(10-7-20-70-62(65)66)54(90)78-42(23-32(2)3)56(92)77-41/h6,9,12-15,19,28-29,31-32,38-48H,5,7-8,10-11,16-18,20-27,30H2,1-4H3,(H2,64,87)(H,68,72)(H,69,88)(H,71,86)(H,73,84)(H,74,85)(H,75,91)(H,76,95)(H,77,92)(H,78,90)(H,79,89)(H,80,93)(H,81,94)(H,82,96)(H4,65,66,70)/t38-,39-,40-,41?,42+,43-,44-,45+,46-,47?,48-/m0/s1
KEGG

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 0.100n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085756
PNG
(CHEMBL439532 | cyclo(1,1'-3)Ac-D-Asp (Gly)-D-Cpa-D...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C68H91ClN16O15/c1-37(2)29-49(61(94)79-48(14-9-27-74-68(71)72)67(100)85-28-10-15-55(85)66(99)76-38(3)58(70)91)80-63(96)52(33-42-16-21-43-11-5-6-12-44(43)30-42)82-62(95)51(32-41-19-24-46(88)25-20-41)83-65(98)54(36-86)84-60(93)47-13-7-8-26-73-59(92)50(31-40-17-22-45(69)23-18-40)81-64(97)53(77-39(4)87)34-56(89)75-35-57(90)78-47/h5-6,11-12,16-25,30,37-38,47-55,86,88H,7-10,13-15,26-29,31-36H2,1-4H3,(H2,70,91)(H,73,92)(H,75,89)(H,76,99)(H,77,87)(H,78,90)(H,79,94)(H,80,96)(H,81,97)(H,82,95)(H,83,98)(H,84,93)(H4,71,72,74)/t38?,47-,48+,49-,50-,51+,52?,53?,54+,55-/m1/s1
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 0.140n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085715
PNG
(CHEMBL266300 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)CNC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C58H83ClN18O14/c1-5-35(68-31(4)78)49(83)73-40(24-32-12-14-34(59)15-13-32)53(87)74-41(25-33-9-6-19-63-27-33)54(88)75-42-26-46(80)66-28-43(48(60)82)76-56(90)44-11-8-22-77(44)57(91)38-18-21-64-47(81)29-67-45(79)17-16-37(70-55(42)89)51(85)69-36(10-7-20-65-58(61)62)50(84)72-39(23-30(2)3)52(86)71-38/h6,9,12-15,19,27,30,35-44H,5,7-8,10-11,16-18,20-26,28-29H2,1-4H3,(H2,60,82)(H,64,81)(H,66,80)(H,67,79)(H,68,78)(H,69,85)(H,70,89)(H,71,86)(H,72,84)(H,73,83)(H,74,87)(H,75,88)(H,76,90)(H4,61,62,65)/t35-,36-,37-,38?,39+,40-,41-,42-,43?,44-/m0/s1
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 0.160n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085742
PNG
(CHEMBL414350 | cyclo(1,1'-3)Ac-D-Asp (beta-Ala)-D-...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NCCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C68H91ClN16O15/c1-37(2)30-49(61(94)79-48(13-8-27-75-68(71)72)67(100)85-29-9-14-55(85)66(99)76-38(3)58(70)91)80-63(96)52(34-42-15-20-43-10-5-6-11-44(43)31-42)82-62(95)51(33-41-18-23-46(88)24-19-41)83-65(98)54(36-86)84-60(93)47-12-7-26-74-59(92)50(32-40-16-21-45(69)22-17-40)81-64(97)53(77-39(4)87)35-57(90)73-28-25-56(89)78-47/h5-6,10-11,15-24,31,37-38,47-55,86,88H,7-9,12-14,25-30,32-36H2,1-4H3,(H2,70,91)(H,73,90)(H,74,92)(H,76,99)(H,77,87)(H,78,89)(H,79,94)(H,80,96)(H,81,97)(H,82,95)(H,83,98)(H,84,93)(H4,71,72,75)/t38?,47-,48+,49-,50-,51+,52?,53?,54+,55-/m1/s1
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 0.170n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085761
PNG
(CHEMBL437038 | cyclo(1,1'-3)Ac-D-Asp (Gaba)-D-Cpa-...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NCCCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C67H89ClN16O15/c1-36(2)28-47(59(92)78-46(12-7-26-73-67(70)71)66(99)84-27-9-13-54(84)65(98)75-37(3)57(69)90)79-61(94)50(32-41-15-20-42-10-5-6-11-43(42)29-41)81-60(93)49(31-40-18-23-45(87)24-19-40)82-64(97)53(35-85)83-63(96)52-34-74-58(91)48(30-39-16-21-44(68)22-17-39)80-62(95)51(76-38(4)86)33-56(89)72-25-8-14-55(88)77-52/h5-6,10-11,15-24,29,36-37,46-54,85,87H,7-9,12-14,25-28,30-35H2,1-4H3,(H2,69,90)(H,72,89)(H,74,91)(H,75,98)(H,76,86)(H,77,88)(H,78,92)(H,79,94)(H,80,95)(H,81,93)(H,82,97)(H,83,96)(H4,70,71,73)/t37?,46-,47+,48+,49-,50?,51?,52+,53-,54+/m0/s1
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 0.180n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085719
PNG
(CHEMBL438543 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)CN(C)C(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C59H85ClN18O14/c1-6-36(68-32(4)79)50(84)73-41(25-33-13-15-35(60)16-14-33)54(88)74-42(26-34-10-7-20-64-28-34)55(89)75-43-27-46(80)67-29-44(49(61)83)76-57(91)45-12-9-23-78(45)58(92)39-19-22-65-47(81)30-77(5)48(82)18-17-38(70-56(43)90)52(86)69-37(11-8-21-66-59(62)63)51(85)72-40(24-31(2)3)53(87)71-39/h7,10,13-16,20,28,31,36-45H,6,8-9,11-12,17-19,21-27,29-30H2,1-5H3,(H2,61,83)(H,65,81)(H,67,80)(H,68,79)(H,69,86)(H,70,90)(H,71,87)(H,72,85)(H,73,84)(H,74,88)(H,75,89)(H,76,91)(H4,62,63,66)/t36-,37-,38-,39?,40+,41-,42-,43-,44?,45-/m0/s1
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 0.200n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085710
PNG
(CHEMBL414756 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@@H](CCCNC(N)=N)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C62H92ClN21O14/c1-5-37(74-33(4)85)52(90)80-43(27-34-14-16-36(63)17-15-34)56(94)81-44(28-35-10-6-21-69-30-35)57(95)82-45-29-49(87)73-31-46(50(64)88)83-59(97)47-13-9-25-84(47)60(98)41-20-24-70-51(89)38(11-7-22-71-61(65)66)75-48(86)19-18-40(77-58(45)96)54(92)76-39(12-8-23-72-62(67)68)53(91)79-42(26-32(2)3)55(93)78-41/h6,10,14-17,21,30,32,37-47H,5,7-9,11-13,18-20,22-29,31H2,1-4H3,(H2,64,88)(H,70,89)(H,73,87)(H,74,85)(H,75,86)(H,76,92)(H,77,96)(H,78,93)(H,79,91)(H,80,90)(H,81,94)(H,82,95)(H,83,97)(H4,65,66,71)(H4,67,68,72)/t37-,38+,39-,40-,41?,42+,43-,44-,45-,46?,47-/m0/s1
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 0.200n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085718
PNG
(CHEMBL410820 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@@H](Cc3ccccc3)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=O)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C65H88ClN17O15/c1-5-41(73-36(4)84)56(89)79-47(30-38-17-19-40(66)20-18-38)60(93)80-48(31-39-14-9-24-69-33-39)61(94)81-49-32-53(86)72-34-50(54(67)87)82-63(96)51-16-11-27-83(51)64(97)44-23-26-70-55(88)46(29-37-12-7-6-8-13-37)74-52(85)22-21-43(76-62(49)95)58(91)75-42(15-10-25-71-65(68)98)57(90)78-45(28-35(2)3)59(92)77-44/h6-9,12-14,17-20,24,33,35,41-51H,5,10-11,15-16,21-23,25-32,34H2,1-4H3,(H2,67,87)(H,70,88)(H,72,86)(H,73,84)(H,74,85)(H,75,91)(H,76,95)(H,77,92)(H,78,90)(H,79,89)(H,80,93)(H,81,94)(H,82,96)(H3,68,71,98)/t41-,42-,43-,44?,45+,46+,47-,48-,49-,50?,51-/m0/s1
KEGG

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 0.200n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085720
PNG
(CHEMBL404930 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@H](Cc3ccccc3)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C65H89ClN18O14/c1-5-41(74-36(4)85)56(90)80-47(30-38-17-19-40(66)20-18-38)60(94)81-48(31-39-14-9-24-70-33-39)61(95)82-49-32-53(87)73-34-50(54(67)88)83-63(97)51-16-11-27-84(51)64(98)44-23-26-71-55(89)46(29-37-12-7-6-8-13-37)75-52(86)22-21-43(77-62(49)96)58(92)76-42(15-10-25-72-65(68)69)57(91)79-45(28-35(2)3)59(93)78-44/h6-9,12-14,17-20,24,33,35,41-51H,5,10-11,15-16,21-23,25-32,34H2,1-4H3,(H2,67,88)(H,71,89)(H,73,87)(H,74,85)(H,75,86)(H,76,92)(H,77,96)(H,78,93)(H,79,91)(H,80,90)(H,81,94)(H,82,95)(H,83,97)(H4,68,69,72)/t41-,42-,43-,44?,45+,46-,47-,48-,49-,50?,51-/m0/s1
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 0.230n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085737
PNG
(CHEMBL438597 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C65H88Cl2N18O14/c1-5-41(75-35(4)86)56(91)81-47(29-37-14-18-40(67)19-15-37)60(95)82-48(30-38-9-6-23-71-32-38)61(96)83-49-31-53(88)74-33-50(54(68)89)84-63(98)51-11-8-26-85(51)64(99)44-22-25-72-55(90)46(28-36-12-16-39(66)17-13-36)76-52(87)21-20-43(78-62(49)97)58(93)77-42(10-7-24-73-65(69)70)57(92)80-45(27-34(2)3)59(94)79-44/h6,9,12-19,23,32,34,41-51H,5,7-8,10-11,20-22,24-31,33H2,1-4H3,(H2,68,89)(H,72,90)(H,74,88)(H,75,86)(H,76,87)(H,77,93)(H,78,97)(H,79,94)(H,80,92)(H,81,91)(H,82,95)(H,83,96)(H,84,98)(H4,69,70,73)/t41-,42-,43-,44?,45+,46+,47-,48-,49-,50?,51-/m0/s1
KEGG

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 0.230n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085732
PNG
(CHEMBL406094 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCCNC(=O)C(Cc3ccccc3)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C66H91ClN18O14/c1-5-42(75-37(4)86)57(91)81-48(31-39-19-21-41(67)22-20-39)61(95)82-49(32-40-15-9-25-71-34-40)62(96)83-50-33-54(88)74-35-51(55(68)89)84-64(98)52-18-12-28-85(52)65(99)45-17-11-26-72-56(90)47(30-38-13-7-6-8-14-38)76-53(87)24-23-44(78-63(50)97)59(93)77-43(16-10-27-73-66(69)70)58(92)80-46(29-36(2)3)60(94)79-45/h6-9,13-15,19-22,25,34,36,42-52H,5,10-12,16-18,23-24,26-33,35H2,1-4H3,(H2,68,89)(H,72,90)(H,74,88)(H,75,86)(H,76,87)(H,77,93)(H,78,97)(H,79,94)(H,80,92)(H,81,91)(H,82,95)(H,83,96)(H,84,98)(H4,69,70,73)/t42-,43-,44-,45?,46+,47?,48-,49-,50-,51?,52-/m0/s1
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 0.270n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085735
PNG
(CHEMBL412681 | Cyclo (5-8) [Ac-D Nal, D Cpa, D Pal...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]1CCC(=O)Nc2ccc(C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(N)=N)NC1=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O)cc2
Show InChI InChI=1S/C61H83ClN16O14/c1-6-40(69-34(5)79)52(84)74-44(27-35-13-17-38(62)18-14-35)56(88)75-45(29-37-10-7-23-66-31-37)57(89)76-46(30-50(81)82)58(90)72-42-21-22-49(80)70-39-19-15-36(16-20-39)28-47(60(92)78-25-9-12-48(78)59(91)68-33(4)51(63)83)77-55(87)43(26-32(2)3)73-53(85)41(71-54(42)86)11-8-24-67-61(64)65/h7,10,13-20,23,31-33,40-48H,6,8-9,11-12,21-22,24-30H2,1-5H3,(H2,63,83)(H,68,91)(H,69,79)(H,70,80)(H,71,86)(H,72,90)(H,73,85)(H,74,84)(H,75,88)(H,76,89)(H,77,87)(H,81,82)(H4,64,65,67)/t33-,40-,41+,42+,43-,44-,45-,46-,47-,48+/m0/s1
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 0.280n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085753
PNG
(CHEMBL409996 | cyclo(1-3)Ac-D-Glu-D-Cpa-D-Dbu-Ser-...)
Show SMILES CCCCC1CC(NC(=O)CCC(NC(C)=O)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C69H94ClN15O14/c1-6-7-14-47-36-55(78-58(89)28-27-49(76-40(5)87)60(91)81-52(61(92)77-47)33-41-18-23-46(70)24-19-41)65(96)84-56(37-86)66(97)83-53(34-42-20-25-48(88)26-21-42)63(94)82-54(35-43-17-22-44-12-8-9-13-45(44)32-43)64(95)80-51(31-38(2)3)62(93)79-50(15-10-29-74-69(72)73)68(99)85-30-11-16-57(85)67(98)75-39(4)59(71)90/h8-9,12-13,17-26,32,38-39,47,49-57,86,88H,6-7,10-11,14-16,27-31,33-37H2,1-5H3,(H2,71,90)(H,75,98)(H,76,87)(H,77,92)(H,78,89)(H,79,93)(H,80,95)(H,81,91)(H,82,94)(H,83,97)(H,84,96)(H4,72,73,74)/t39?,47?,49?,50-,51+,52+,53-,54?,55?,56-,57+/m0/s1
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 0.310n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085757
PNG
(CHEMBL427745 | cyclo(1,1'-3)Ac-D-Asp (beta-Ala)-D-...)
Show SMILES CCCCC1C[C@@H](NC(=O)CCNC(=O)CC(NC(C)=O)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C71H97ClN16O15/c1-6-7-14-48-36-55(81-59(92)27-29-76-60(93)37-56(79-41(5)90)67(100)84-52(62(95)80-48)33-42-18-23-47(72)24-19-42)66(99)87-57(38-89)68(101)86-53(34-43-20-25-49(91)26-21-43)64(97)85-54(35-44-17-22-45-12-8-9-13-46(45)32-44)65(98)83-51(31-39(2)3)63(96)82-50(15-10-28-77-71(74)75)70(103)88-30-11-16-58(88)69(102)78-40(4)61(73)94/h8-9,12-13,17-26,32,39-40,48,50-58,89,91H,6-7,10-11,14-16,27-31,33-38H2,1-5H3,(H2,73,94)(H,76,93)(H,78,102)(H,79,90)(H,80,95)(H,81,92)(H,82,96)(H,83,98)(H,84,100)(H,85,97)(H,86,101)(H,87,99)(H4,74,75,77)/t40?,48?,50-,51+,52+,53-,54?,55+,56?,57-,58+/m0/s1
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 0.320n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085711
PNG
(CHEMBL412682 | DiCyclo (4-10/5-8) [Ac-D Nal, D Cpa...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCCNC(=O)CC[C@H](NC1=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C61H86ClN17O13/c1-5-38(70-33(4)80)52(84)75-44(27-34-17-19-36(62)20-18-34)56(88)76-45(28-35-30-68-39-13-7-6-12-37(35)39)57(89)77-46-29-50(82)69-31-47(51(63)83)78-59(91)48-16-11-25-79(48)60(92)42-14-8-9-23-66-49(81)22-21-41(72-58(46)90)54(86)71-40(15-10-24-67-61(64)65)53(85)74-43(26-32(2)3)55(87)73-42/h6-7,12-13,17-20,30,32,38,40-48,68H,5,8-11,14-16,21-29,31H2,1-4H3,(H2,63,83)(H,66,81)(H,69,82)(H,70,80)(H,71,86)(H,72,90)(H,73,87)(H,74,85)(H,75,84)(H,76,88)(H,77,89)(H,78,91)(H4,64,65,67)/t38-,40+,41-,42+,43-,44-,45-,46-,47?,48-/m0/s1
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 0.320n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085704
PNG
(CHEMBL440436 | Cyclo (4-10) [Ac-D Nal, D Cpa, D Pa...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H]1CC(=O)N(CC(N)=O)C(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CCC(O)=O)NC1=O
Show InChI InChI=1S/C57H83ClN16O14/c1-5-36(65-32(4)75)48(80)70-41(26-33-15-17-35(58)18-16-33)52(84)71-42(27-34-11-8-22-63-29-34)53(85)72-43-28-46(77)74(30-45(60)76)56(88)44-14-10-24-73(44)55(87)39(12-6-7-21-59)68-51(83)40(25-31(2)3)69-49(81)37(13-9-23-64-57(61)62)66-50(82)38(67-54(43)86)19-20-47(78)79/h8,11,15-18,22,29,31,36-44H,5-7,9-10,12-14,19-21,23-28,30,59H2,1-4H3,(H2,60,76)(H,65,75)(H,66,82)(H,67,86)(H,68,83)(H,69,81)(H,70,80)(H,71,84)(H,72,85)(H,78,79)(H4,61,62,64)/t36-,37-,38+,39-,40+,41-,42-,43+,44+/m0/s1
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 0.320n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085746
PNG
(CHEMBL405223 | cyclo(1,1'-3)Ac-D-Asp (Gly)-D-Cpa-D...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C67H89ClN16O15/c1-36(2)28-48(60(93)78-47(13-8-26-73-67(70)71)66(99)84-27-9-14-54(84)65(98)75-37(3)57(69)90)79-62(95)51(32-41-15-20-42-10-5-6-11-43(42)29-41)81-61(94)50(31-40-18-23-45(87)24-19-40)82-64(97)53(35-85)83-59(92)46-12-7-25-72-58(91)49(30-39-16-21-44(68)22-17-39)80-63(96)52(76-38(4)86)33-55(88)74-34-56(89)77-46/h5-6,10-11,15-24,29,36-37,46-54,85,87H,7-9,12-14,25-28,30-35H2,1-4H3,(H2,69,90)(H,72,91)(H,74,88)(H,75,98)(H,76,86)(H,77,89)(H,78,93)(H,79,95)(H,80,96)(H,81,94)(H,82,97)(H,83,92)(H4,70,71,73)/t37?,46-,47+,48-,49-,50+,51?,52?,53+,54-/m1/s1
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 0.340n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085751
PNG
(CHEMBL437230 | cyclo(1,1'-3)Ac-D-Asp (beta-Ala)-D-...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NCCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C66H87ClN16O15/c1-35(2)27-46(58(91)77-45(11-7-24-72-66(69)70)65(98)83-26-8-12-53(83)64(97)74-36(3)56(68)89)78-60(93)49(31-40-13-18-41-9-5-6-10-42(41)28-40)80-59(92)48(30-39-16-21-44(86)22-17-39)81-63(96)52(34-84)82-62(95)51-33-73-57(90)47(29-38-14-19-43(67)20-15-38)79-61(94)50(75-37(4)85)32-55(88)71-25-23-54(87)76-51/h5-6,9-10,13-22,28,35-36,45-53,84,86H,7-8,11-12,23-27,29-34H2,1-4H3,(H2,68,89)(H,71,88)(H,73,90)(H,74,97)(H,75,85)(H,76,87)(H,77,91)(H,78,93)(H,79,94)(H,80,92)(H,81,96)(H,82,95)(H4,69,70,72)/t36?,45-,46+,47+,48-,49?,50?,51+,52-,53+/m0/s1
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 0.350n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085722
PNG
(CHEMBL413896 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H]1CC(=O)NCC(NC(=O)[C@H]2CCCN2C(=O)C2CCNC(=O)CNC(=O)C[C@@H](NC1=O)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C57H81ClN18O14/c1-5-34(67-30(4)77)48(82)71-38(22-31-12-14-33(58)15-13-31)51(85)72-39(23-32-9-6-17-62-26-32)52(86)73-41-24-44(78)65-27-42(47(59)81)75-55(89)43-11-8-20-76(43)56(90)36-16-19-63-46(80)28-66-45(79)25-40(74-54(41)88)53(87)68-35(10-7-18-64-57(60)61)49(83)70-37(21-29(2)3)50(84)69-36/h6,9,12-15,17,26,29,34-43H,5,7-8,10-11,16,18-25,27-28H2,1-4H3,(H2,59,81)(H,63,80)(H,65,78)(H,66,79)(H,67,77)(H,68,87)(H,69,84)(H,70,83)(H,71,82)(H,72,85)(H,73,86)(H,74,88)(H,75,89)(H4,60,61,64)/t34-,35+,36?,37+,38-,39-,40+,41+,42?,43+/m0/s1
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 0.350n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085730
PNG
(CHEMBL407074 | Cyclo (4-10) [Ac-D Nal, D Fpa, D Tr...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC1=O)C(N)=O
Show InChI InChI=1S/C61H88FN17O14/c1-5-38(70-33(4)80)52(85)75-44(27-34-17-19-36(62)20-18-34)56(89)76-45(28-35-30-68-39-13-7-6-12-37(35)39)57(90)77-46-29-49(81)69-31-47(51(64)84)78-59(92)48-16-11-25-79(48)60(93)42(14-8-9-23-63)73-55(88)43(26-32(2)3)74-53(86)40(15-10-24-67-61(65)66)71-54(87)41(72-58(46)91)21-22-50(82)83/h6-7,12-13,17-20,30,32,38,40-48,68H,5,8-11,14-16,21-29,31,63H2,1-4H3,(H2,64,84)(H,69,81)(H,70,80)(H,71,87)(H,72,91)(H,73,88)(H,74,86)(H,75,85)(H,76,89)(H,77,90)(H,78,92)(H,82,83)(H4,65,66,67)/t38-,40+,41-,42+,43-,44-,45-,46-,47?,48-/m0/s1
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 0.360n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085729
PNG
(CHEMBL438902 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)CCNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C58H83ClN18O14/c1-5-35(68-31(4)78)49(83)72-39(24-32-12-14-34(59)15-13-32)52(86)73-40(25-33-9-6-18-63-28-33)53(87)74-42-27-47(81)67-29-43(48(60)82)76-56(90)44-11-8-22-77(44)57(91)37-16-20-64-45(79)17-21-65-46(80)26-41(75-55(42)89)54(88)69-36(10-7-19-66-58(61)62)50(84)71-38(23-30(2)3)51(85)70-37/h6,9,12-15,18,28,30,35-44H,5,7-8,10-11,16-17,19-27,29H2,1-4H3,(H2,60,82)(H,64,79)(H,65,80)(H,67,81)(H,68,78)(H,69,88)(H,70,85)(H,71,84)(H,72,83)(H,73,86)(H,74,87)(H,75,89)(H,76,90)(H4,61,62,66)/t35-,36-,37?,38+,39-,40-,41-,42-,43?,44-/m0/s1
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 0.370n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085748
PNG
(CHEMBL407186 | cyclo(1-3)Ac-D-Glu-D-Cpa-D-Lys-Ser-...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C67H90ClN15O14/c1-37(2)31-50(61(92)77-49(14-9-29-73-67(70)71)66(97)83-30-10-15-55(83)65(96)74-38(3)57(69)88)78-63(94)53(35-42-16-21-43-11-5-6-12-44(43)32-42)80-62(93)52(34-41-19-24-46(86)25-20-41)81-64(95)54(36-84)82-59(90)47-13-7-8-28-72-58(89)51(33-40-17-22-45(68)23-18-40)79-60(91)48(75-39(4)85)26-27-56(87)76-47/h5-6,11-12,16-25,32,37-38,47-55,84,86H,7-10,13-15,26-31,33-36H2,1-4H3,(H2,69,88)(H,72,89)(H,74,96)(H,75,85)(H,76,87)(H,77,92)(H,78,94)(H,79,91)(H,80,93)(H,81,95)(H,82,90)(H4,70,71,73)/t38?,47-,48?,49+,50-,51-,52+,53?,54+,55-/m1/s1
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 0.470n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085763
PNG
(CHEMBL264291 | cyclo(1-3)Ac-D-Asp (D-Ala)-D-Cpa-D-...)
Show SMILES CCCCC1C[C@@H](NC(=O)[C@@H](C)NC(=O)CC(NC(C)=O)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C71H97ClN16O15/c1-7-8-15-48-35-55(82-61(94)40(5)77-59(92)36-56(79-41(6)90)67(100)84-52(62(95)80-48)32-42-19-24-47(72)25-20-42)66(99)87-57(37-89)68(101)86-53(33-43-21-26-49(91)27-22-43)64(97)85-54(34-44-18-23-45-13-9-10-14-46(45)31-44)65(98)83-51(30-38(2)3)63(96)81-50(16-11-28-76-71(74)75)70(103)88-29-12-17-58(88)69(102)78-39(4)60(73)93/h9-10,13-14,18-27,31,38-40,48,50-58,89,91H,7-8,11-12,15-17,28-30,32-37H2,1-6H3,(H2,73,93)(H,77,92)(H,78,102)(H,79,90)(H,80,95)(H,81,96)(H,82,94)(H,83,98)(H,84,100)(H,85,97)(H,86,101)(H,87,99)(H4,74,75,76)/t39?,40-,48?,50+,51-,52-,53+,54?,55-,56?,57+,58-/m1/s1
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 0.570n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085705
PNG
(CHEMBL262373 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@@H](CCCNC(N)=N)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C64H88ClN19O14/c1-5-40(74-35(4)85)55(90)79-45(27-36-14-16-39(65)17-15-36)58(93)81-47(29-38-11-7-22-70-32-38)60(95)82-48-30-52(87)73-33-49(53(66)88)83-62(97)50-13-9-25-84(50)63(98)43-20-24-71-54(89)41(12-8-23-72-64(67)68)75-51(86)19-18-42(76-61(48)96)56(91)80-46(28-37-10-6-21-69-31-37)59(94)78-44(26-34(2)3)57(92)77-43/h6-7,10-11,14-17,21-22,31-32,34,40-50H,5,8-9,12-13,18-20,23-30,33H2,1-4H3,(H2,66,88)(H,71,89)(H,73,87)(H,74,85)(H,75,86)(H,76,96)(H,77,92)(H,78,94)(H,79,90)(H,80,91)(H,81,93)(H,82,95)(H,83,97)(H4,67,68,72)/t40-,41+,42-,43?,44+,45-,46-,47-,48-,49?,50-/m0/s1
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 0.590n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085752
PNG
(CHEMBL436661 | cyclo(1,1'-3)Ac-D-Asp (Gly)-D-Cpa-D...)
Show SMILES CCCCC1C[C@@H](NC(=O)CNC(=O)CC(NC(C)=O)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C70H95ClN16O15/c1-6-7-14-47-34-54(80-59(92)36-76-58(91)35-55(78-40(5)89)66(99)83-51(61(94)79-47)31-41-18-23-46(71)24-19-41)65(98)86-56(37-88)67(100)85-52(32-42-20-25-48(90)26-21-42)63(96)84-53(33-43-17-22-44-12-8-9-13-45(44)30-43)64(97)82-50(29-38(2)3)62(95)81-49(15-10-27-75-70(73)74)69(102)87-28-11-16-57(87)68(101)77-39(4)60(72)93/h8-9,12-13,17-26,30,38-39,47,49-57,88,90H,6-7,10-11,14-16,27-29,31-37H2,1-5H3,(H2,72,93)(H,76,91)(H,77,101)(H,78,89)(H,79,94)(H,80,92)(H,81,95)(H,82,97)(H,83,99)(H,84,96)(H,85,100)(H,86,98)(H4,73,74,75)/t39?,47?,49-,50+,51+,52-,53?,54+,55?,56-,57+/m0/s1
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 0.700n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085707
PNG
(CHEMBL411197 | Cyclo (4-10) [Ac-Delta Pro, D Fpa, ...)
Show SMILES CC(C)C[C@H]1NC(=O)[C@H](C)NC(=O)[C@@](C)(Cc2ccc(O)cc2)NC(=O)[C@@H](CC(=O)NCC(NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC1=O)C(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1CCCN1C(C)=O
Show InChI InChI=1S/C64H85FN14O13/c1-35(2)28-46-56(85)71-45(14-8-9-25-66)62(91)79-27-11-16-52(79)61(90)76-50(54(67)83)34-69-53(82)31-49(59(88)77-64(5,32-39-19-23-42(81)24-20-39)63(92)70-36(3)55(84)72-46)74-58(87)48(30-40-33-68-44-13-7-6-12-43(40)44)73-57(86)47(29-38-17-21-41(65)22-18-38)75-60(89)51-15-10-26-78(51)37(4)80/h6-7,12-13,17-24,33,35-36,45-52,68,81H,8-11,14-16,25-32,34,66H2,1-5H3,(H2,67,83)(H,69,82)(H,70,92)(H,71,85)(H,72,84)(H,73,86)(H,74,87)(H,75,89)(H,76,90)(H,77,88)/t36-,45-,46+,47-,48-,49+,50?,51-,52+,64+/m0/s1
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 0.740n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085725
PNG
(CHEMBL439256 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCCNC(=O)[C@@H](Cc3ccccc3)NC(=O)C[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C65H89ClN18O14/c1-5-41(74-36(4)85)56(90)79-46(29-38-19-21-40(66)22-20-38)59(93)80-47(30-39-15-9-23-70-33-39)60(94)81-48-31-52(86)73-34-50(54(67)88)83-63(97)51-18-12-26-84(51)64(98)43-17-11-24-71-55(89)45(28-37-13-7-6-8-14-37)75-53(87)32-49(82-62(48)96)61(95)76-42(16-10-25-72-65(68)69)57(91)78-44(27-35(2)3)58(92)77-43/h6-9,13-15,19-23,33,35,41-51H,5,10-12,16-18,24-32,34H2,1-4H3,(H2,67,88)(H,71,89)(H,73,86)(H,74,85)(H,75,87)(H,76,95)(H,77,92)(H,78,91)(H,79,90)(H,80,93)(H,81,94)(H,82,96)(H,83,97)(H4,68,69,72)/t41-,42-,43?,44+,45+,46-,47-,48-,49-,50?,51-/m0/s1
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 0.75n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085760
PNG
(CHEMBL262637 | cyclo(1-3)Ac-D-Asp-D-Cpa-D-Lys-Ser-...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)C1CCCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C66H88ClN15O14/c1-36(2)29-48(59(90)76-47(14-9-27-72-66(69)70)65(96)82-28-10-15-54(82)64(95)73-37(3)56(68)87)77-61(92)51(33-41-16-21-42-11-5-6-12-43(42)30-41)79-60(91)50(32-40-19-24-45(85)25-20-40)80-63(94)53(35-83)81-58(89)46-13-7-8-26-71-57(88)49(31-39-17-22-44(67)23-18-39)78-62(93)52(74-38(4)84)34-55(86)75-46/h5-6,11-12,16-25,30,36-37,46-54,83,85H,7-10,13-15,26-29,31-35H2,1-4H3,(H2,68,87)(H,71,88)(H,73,95)(H,74,84)(H,75,86)(H,76,90)(H,77,92)(H,78,93)(H,79,91)(H,80,94)(H,81,89)(H4,69,70,72)/t37?,46?,47-,48+,49+,50-,51?,52?,53-,54+/m0/s1
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 0.820n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085709
PNG
(CHEMBL428317 | Cyclo (5-8) [Ac-D Nal, D Cpa, D Trp...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC)NC1=O)C(=O)N1CCC[C@@H]1C(=O)NC(CN)C(N)=O
Show InChI InChI=1S/C59H83ClN14O14/c1-6-37(65-32(5)75)51(80)70-43(26-33-17-19-35(60)20-18-33)55(84)71-44(27-34-30-64-39-14-9-8-13-36(34)39)56(85)72-45(28-49(77)78)57(86)67-40-21-22-48(76)63-23-11-10-15-41(59(88)74-24-12-16-47(74)58(87)73-46(29-61)50(62)79)68-54(83)42(25-31(3)4)69-52(81)38(7-2)66-53(40)82/h8-9,13-14,17-20,30-31,37-38,40-47,64H,6-7,10-12,15-16,21-29,61H2,1-5H3,(H2,62,79)(H,63,76)(H,65,75)(H,66,82)(H,67,86)(H,68,83)(H,69,81)(H,70,80)(H,71,84)(H,72,85)(H,73,87)(H,77,78)/t37-,38+,40+,41-,42-,43-,44-,45-,46?,47+/m0/s1
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 1n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085728
PNG
(CHEMBL409340 | DiCyclo (4-10/5-8) [Ac-D Nal, D Cpa...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CC(=O)NCC(NC(=O)[C@H]2CCCN2C(=O)[C@@H]2CCCCNC(=O)CC[C@@H](NC1=O)C(=O)N[C@@H](CC)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C59H81ClN14O13/c1-6-37(65-32(5)75)51(79)70-43(26-33-17-19-35(60)20-18-33)55(83)71-44(27-34-29-63-39-14-9-8-13-36(34)39)56(84)72-45-28-49(77)64-30-46(50(61)78)73-58(86)47-16-12-24-74(47)59(87)41-15-10-11-23-62-48(76)22-21-40(67-57(45)85)53(81)66-38(7-2)52(80)69-42(25-31(3)4)54(82)68-41/h8-9,13-14,17-20,29,31,37-38,40-47,63H,6-7,10-12,15-16,21-28,30H2,1-5H3,(H2,61,78)(H,62,76)(H,64,77)(H,65,75)(H,66,81)(H,67,85)(H,68,82)(H,69,80)(H,70,79)(H,71,83)(H,72,84)(H,73,86)/t37-,38-,40+,41-,42+,43-,44-,45+,46?,47+/m0/s1
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 1.20n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085744
PNG
(CHEMBL430344 | dicyclo(1-3, 4-10)Ac-D-Asp-D-Cpa-D-...)
Show SMILES CC(C)C[C@@H]1NC(=O)C(Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(=O)NC(CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCNC(N)=N)NC1=O)C(O)=O)NC(=O)C1CCCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)N1)NC(C)=O
Show InChI InChI=1S/C67H86ClN15O15/c1-36(2)28-47-59(90)77-46(13-8-26-72-67(69)70)65(96)83-27-9-14-54(83)64(95)73-35-53(66(97)98)76-56(87)34-52(63(94)80-49(31-39-18-23-44(85)24-19-39)60(91)81-50(61(92)78-47)32-40-15-20-41-10-4-5-11-42(41)29-40)82-58(89)45-12-6-7-25-71-57(88)48(30-38-16-21-43(68)22-17-38)79-62(93)51(74-37(3)84)33-55(86)75-45/h4-5,10-11,15-24,29,36,45-54,85H,6-9,12-14,25-28,30-35H2,1-3H3,(H,71,88)(H,73,95)(H,74,84)(H,75,86)(H,76,87)(H,77,90)(H,78,92)(H,79,93)(H,80,94)(H,81,91)(H,82,89)(H,97,98)(H4,69,70,72)/t45?,46-,47+,48-,49+,50?,51?,52+,53?,54+/m1/s1
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 1.20n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085727
PNG
(CHEMBL385090 | Cyclo (5-8) [Ac-D Nal, D Cpa, D Pal...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]1CC(=O)Nc2ccc(C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc3cccnc3)NC1=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O)cc2
Show InChI InChI=1S/C62H77ClN14O14/c1-6-42(68-35(5)78)54(83)71-44(25-36-13-17-40(63)18-14-36)56(85)72-46(28-39-11-8-22-66-32-39)58(87)75-48(30-52(80)81)60(89)74-47-29-51(79)69-41-19-15-37(16-20-41)26-49(62(91)77-23-9-12-50(77)61(90)67-34(4)53(64)82)76-55(84)43(24-33(2)3)70-57(86)45(73-59(47)88)27-38-10-7-21-65-31-38/h7-8,10-11,13-22,31-34,42-50H,6,9,12,23-30H2,1-5H3,(H2,64,82)(H,67,90)(H,68,78)(H,69,79)(H,70,86)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,87)(H,76,84)(H,80,81)/t34-,42-,43-,44-,45+,46-,47+,48-,49-,50+/m0/s1
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 1.30n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085738
PNG
(CHEMBL267984 | Cyclo (4-10) [Ac-D Nal, D Fpa, D Tr...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H]1CCC(=O)N(CC(N)=O)C(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CCC(O)=O)NC1=O
Show InChI InChI=1S/C61H87FN16O14/c1-5-39(69-34(4)79)52(84)75-46(29-35-17-19-37(62)20-18-35)57(89)76-47(30-36-31-68-40-13-7-6-12-38(36)40)58(90)72-42-21-23-50(81)78(32-49(64)80)60(92)48-16-11-27-77(48)59(91)44(14-8-9-25-63)73-56(88)45(28-33(2)3)74-53(85)41(15-10-26-67-61(65)66)70-55(87)43(71-54(42)86)22-24-51(82)83/h6-7,12-13,17-20,31,33,39,41-48,68H,5,8-11,14-16,21-30,32,63H2,1-4H3,(H2,64,80)(H,69,79)(H,70,87)(H,71,86)(H,72,90)(H,73,88)(H,74,85)(H,75,84)(H,76,89)(H,82,83)(H4,65,66,67)/t39-,41-,42+,43+,44-,45+,46-,47-,48+/m0/s1
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 1.30n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085723
PNG
(CHEMBL407185 | DiCyclo (4-10/5-8) [Ac-D Nal, D Cpa...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)[C@H]2CCCCNC(=O)CC[C@H](NC1=O)C(=O)N[C@H](CC)C(=O)N[C@@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C56H79ClN14O13/c1-6-35(62-31(5)72)48(76)67-40(25-32-15-17-34(57)18-16-32)52(80)68-41(26-33-12-10-21-59-28-33)53(81)69-42-27-46(74)61-29-43(47(58)75)70-55(83)44-14-11-23-71(44)56(84)38-13-8-9-22-60-45(73)20-19-37(64-54(42)82)50(78)63-36(7-2)49(77)66-39(24-30(3)4)51(79)65-38/h10,12,15-18,21,28,30,35-44H,6-9,11,13-14,19-20,22-27,29H2,1-5H3,(H2,58,75)(H,60,73)(H,61,74)(H,62,72)(H,63,78)(H,64,82)(H,65,79)(H,66,77)(H,67,76)(H,68,80)(H,69,81)(H,70,83)/t35-,36+,37-,38+,39-,40-,41-,42-,43?,44-/m0/s1
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 1.30n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085717
PNG
(CHEMBL414556 | Cyclo (4-10) [Ac-D Nal, D Fpa, D Tr...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H]1CC(=O)N(CC(O)=O)C(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC1=O
Show InChI InChI=1S/C60H85FN16O14/c1-5-38(68-33(4)78)51(83)73-44(27-34-17-19-36(61)20-18-34)55(87)74-45(28-35-30-67-39-13-7-6-12-37(35)39)56(88)75-46-29-49(80)77(31-50(81)82)59(91)47-16-11-25-76(47)58(90)42(14-8-9-23-62)71-54(86)43(26-32(2)3)72-52(84)40(15-10-24-66-60(64)65)69-53(85)41(70-57(46)89)21-22-48(63)79/h6-7,12-13,17-20,30,32,38,40-47,67H,5,8-11,14-16,21-29,31,62H2,1-4H3,(H2,63,79)(H,68,78)(H,69,85)(H,70,89)(H,71,86)(H,72,84)(H,73,83)(H,74,87)(H,75,88)(H,81,82)(H4,64,65,66)/t38-,40+,41-,42+,43-,44-,45-,46-,47-/m0/s1
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 1.30n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085758
PNG
(CHEMBL410558 | cyclo(1,1'-3)Ac-D-Glu (Gly)-D-Cpa-D...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CCC(=O)NCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C69H93ClN16O15/c1-38(2)31-51(63(96)80-50(14-9-29-75-69(72)73)68(101)86-30-10-15-56(86)67(100)77-39(3)59(71)92)81-65(98)54(35-43-16-21-44-11-5-6-12-45(44)32-43)83-64(97)53(34-42-19-24-47(89)25-20-42)84-66(99)55(37-87)85-61(94)48-13-7-8-28-74-60(93)52(33-41-17-22-46(70)23-18-41)82-62(95)49(78-40(4)88)26-27-57(90)76-36-58(91)79-48/h5-6,11-12,16-25,32,38-39,48-56,87,89H,7-10,13-15,26-31,33-37H2,1-4H3,(H2,71,92)(H,74,93)(H,76,90)(H,77,100)(H,78,88)(H,79,91)(H,80,96)(H,81,98)(H,82,95)(H,83,97)(H,84,99)(H,85,94)(H4,72,73,75)/t39?,48-,49?,50+,51-,52-,53+,54?,55+,56-/m1/s1
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 1.5n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085750
PNG
(CHEMBL406214 | cyclo(1-3)Ac-D-Asp-D-Cpa-D-Orn-Ser-...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)C1CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C65H86ClN15O14/c1-35(2)28-47(58(89)75-46(13-8-26-71-65(68)69)64(95)81-27-9-14-53(81)63(94)72-36(3)55(67)86)76-60(91)50(32-40-15-20-41-10-5-6-11-42(41)29-40)78-59(90)49(31-39-18-23-44(84)24-19-39)79-62(93)52(34-82)80-57(88)45-12-7-25-70-56(87)48(30-38-16-21-43(66)22-17-38)77-61(92)51(73-37(4)83)33-54(85)74-45/h5-6,10-11,15-24,29,35-36,45-53,82,84H,7-9,12-14,25-28,30-34H2,1-4H3,(H2,67,86)(H,70,87)(H,72,94)(H,73,83)(H,74,85)(H,75,89)(H,76,91)(H,77,92)(H,78,90)(H,79,93)(H,80,88)(H4,68,69,71)/t36?,45?,46-,47+,48+,49-,50?,51?,52-,53+/m0/s1
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 1.60n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085759
PNG
(CHEMBL406626 | cyclo(1-3)Ac-D-Dpr-D-Cpa-D-Asp-Ser-...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)C1CC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NCC(NC(C)=O)C(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C63H82ClN15O14/c1-33(2)25-44(55(86)73-43(11-7-23-68-63(66)67)62(93)79-24-8-12-51(79)61(92)70-34(3)53(65)84)74-57(88)47(29-38-13-18-39-9-5-6-10-40(39)26-38)75-56(87)46(28-37-16-21-42(82)22-17-37)76-60(91)50(32-80)78-58(89)48-30-52(83)72-45(27-36-14-19-41(64)20-15-36)54(85)69-31-49(59(90)77-48)71-35(4)81/h5-6,9-10,13-22,26,33-34,43-51,80,82H,7-8,11-12,23-25,27-32H2,1-4H3,(H2,65,84)(H,69,85)(H,70,92)(H,71,81)(H,72,83)(H,73,86)(H,74,88)(H,75,87)(H,76,91)(H,77,90)(H,78,89)(H4,66,67,68)/t34?,43-,44+,45-,46-,47?,48?,49?,50-,51+/m0/s1
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 1.70n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085713
PNG
(CHEMBL262160 | Cyclo (5,5'-8) [Ac-D Nal, Cpa, D Pa...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]1CCC(=O)NCCC(=O)NC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(N)=N)NC1=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C60H86ClN17O16/c1-6-37(69-33(5)79)51(86)74-42(27-34-13-15-36(61)16-14-34)55(90)75-43(28-35-10-7-22-65-30-35)56(91)76-44(29-49(83)84)57(92)71-39-17-19-46(80)66-24-21-48(82)77-47(81)20-18-40(59(94)78-25-9-12-45(78)58(93)68-32(4)50(62)85)72-54(89)41(26-31(2)3)73-52(87)38(70-53(39)88)11-8-23-67-60(63)64/h7,10,13-16,22,30-32,37-45H,6,8-9,11-12,17-21,23-29H2,1-5H3,(H2,62,85)(H,66,80)(H,68,93)(H,69,79)(H,70,88)(H,71,92)(H,72,89)(H,73,87)(H,74,86)(H,75,90)(H,76,91)(H,83,84)(H4,63,64,67)(H,77,81,82)/t32-,37-,38+,39+,40-,41-,42-,43-,44-,45+/m0/s1
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 1.80n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085767
PNG
(CHEMBL262106 | cyclo(1,1'-3)Ac-D-Asp (Ala)-D-Cpa-D...)
Show SMILES CCCCC1C[C@@H](NC(=O)C(C)NC(=O)CC(NC(C)=O)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NC(Cc1ccc2ccccc2c1)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C71H97ClN16O15/c1-7-8-15-48-35-55(82-61(94)40(5)77-59(92)36-56(79-41(6)90)67(100)84-52(62(95)80-48)32-42-19-24-47(72)25-20-42)66(99)87-57(37-89)68(101)86-53(33-43-21-26-49(91)27-22-43)64(97)85-54(34-44-18-23-45-13-9-10-14-46(45)31-44)65(98)83-51(30-38(2)3)63(96)81-50(16-11-28-76-71(74)75)70(103)88-29-12-17-58(88)69(102)78-39(4)60(73)93/h9-10,13-14,18-27,31,38-40,48,50-58,89,91H,7-8,11-12,15-17,28-30,32-37H2,1-6H3,(H2,73,93)(H,77,92)(H,78,102)(H,79,90)(H,80,95)(H,81,96)(H,82,94)(H,83,98)(H,84,100)(H,85,97)(H,86,101)(H,87,99)(H4,74,75,76)/t39?,40?,48?,50-,51+,52+,53-,54?,55+,56?,57-,58+/m0/s1
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 1.80n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085713
PNG
(CHEMBL262160 | Cyclo (5,5'-8) [Ac-D Nal, Cpa, D Pa...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]1CCC(=O)NCCC(=O)NC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(N)=N)NC1=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C60H86ClN17O16/c1-6-37(69-33(5)79)51(86)74-42(27-34-13-15-36(61)16-14-34)55(90)75-43(28-35-10-7-22-65-30-35)56(91)76-44(29-49(83)84)57(92)71-39-17-19-46(80)66-24-21-48(82)77-47(81)20-18-40(59(94)78-25-9-12-45(78)58(93)68-32(4)50(62)85)72-54(89)41(26-31(2)3)73-52(87)38(70-53(39)88)11-8-23-67-60(63)64/h7,10,13-16,22,30-32,37-45H,6,8-9,11-12,17-21,23-29H2,1-5H3,(H2,62,85)(H,66,80)(H,68,93)(H,69,79)(H,70,88)(H,71,92)(H,72,89)(H,73,87)(H,74,86)(H,75,90)(H,76,91)(H,83,84)(H4,63,64,67)(H,77,81,82)/t32-,37-,38+,39+,40-,41-,42-,43-,44-,45+/m0/s1
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 1.80n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085741
PNG
(CHEMBL407082 | cyclo(1,1'-3)Ac-D-Glu (beta-Ala)-D-...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CCC(=O)NCCC(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C70H95ClN16O15/c1-39(2)33-52(64(97)81-51(14-9-30-77-70(73)74)69(102)87-32-10-15-57(87)68(101)78-40(3)60(72)93)82-66(99)55(37-44-16-21-45-11-5-6-12-46(45)34-44)84-65(98)54(36-43-19-24-48(90)25-20-43)85-67(100)56(38-88)86-62(95)49-13-7-8-29-76-61(94)53(35-42-17-22-47(71)23-18-42)83-63(96)50(79-41(4)89)26-27-58(91)75-31-28-59(92)80-49/h5-6,11-12,16-25,34,39-40,49-57,88,90H,7-10,13-15,26-33,35-38H2,1-4H3,(H2,72,93)(H,75,91)(H,76,94)(H,78,101)(H,79,89)(H,80,92)(H,81,97)(H,82,99)(H,83,96)(H,84,98)(H,85,100)(H,86,95)(H4,73,74,77)/t40?,49-,50?,51+,52-,53-,54+,55?,56+,57-/m1/s1
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 2.20n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085743
PNG
(CHEMBL404991 | cyclo(1,1'-3)Ac-D-Orn (beta-Ala)-D-...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)C1CC(=O)NCCC(=O)NCCCC(NC(C)=O)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C68H91ClN16O15/c1-37(2)30-49(60(93)78-48(13-8-27-75-68(71)72)67(100)85-29-9-14-55(85)66(99)76-38(3)58(70)91)79-63(96)52(34-42-15-20-43-10-5-6-11-44(43)31-42)81-61(94)51(33-41-18-23-46(88)24-19-41)82-65(98)54(36-86)84-64(97)53-35-57(90)74-28-25-56(89)73-26-7-12-47(77-39(4)87)59(92)80-50(62(95)83-53)32-40-16-21-45(69)22-17-40/h5-6,10-11,15-24,31,37-38,47-55,86,88H,7-9,12-14,25-30,32-36H2,1-4H3,(H2,70,91)(H,73,89)(H,74,90)(H,76,99)(H,77,87)(H,78,93)(H,79,96)(H,80,92)(H,81,94)(H,82,98)(H,83,95)(H,84,97)(H4,71,72,75)/t38?,47?,48-,49+,50+,51-,52?,53?,54-,55+/m0/s1
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 2.20n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085712
PNG
(CHEMBL216534 | Cyclo (5-8) [Ac-D Nal, D Cpa, D Trp...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]1CCC(=O)C(C)(C)OC(C(=O)N2CCC[C@@H]2C(=O)N[C@@H](C)C(N)=O)C(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(N)=N)NC1=O
Show InChI InChI=1S/C60H83ClN14O15/c1-8-37(68-32(5)76)51(82)72-42(26-33-17-19-35(61)20-18-33)54(85)73-43(27-34-29-66-38-14-10-9-13-36(34)38)55(86)74-44(28-47(78)79)56(87)70-40-21-22-46(77)60(6,7)90-49(58(89)75-24-12-16-45(75)57(88)67-31(4)50(62)81)48(80)41(25-30(2)3)71-52(83)39(69-53(40)84)15-11-23-65-59(63)64/h9-10,13-14,17-20,29-31,37,39-45,49,66H,8,11-12,15-16,21-28H2,1-7H3,(H2,62,81)(H,67,88)(H,68,76)(H,69,84)(H,70,87)(H,71,83)(H,72,82)(H,73,85)(H,74,86)(H,78,79)(H4,63,64,65)/t31-,37-,39+,40+,41-,42-,43-,44-,45+,49?/m0/s1
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 2.30n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085733
PNG
(CHEMBL410819 | Cyclo (5-8) [Ac-D Nal, D Cpa, D Pal...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CC(=O)N[C@@H]1CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCNC(N)=N)NC1=O)C(=O)N1CCC[C@@H]1C(=O)NCC(N)=O)C(O)=O
Show InChI InChI=1S/C52H74ClN15O13S2/c1-5-32(60-28(4)69)43(72)64-35(20-29-12-14-31(53)15-13-29)46(75)65-36(21-30-9-6-16-57-23-30)47(76)66-37(51(80)81)22-42(71)61-38-25-82-83-26-39(50(79)68-18-8-11-40(68)49(78)59-24-41(54)70)67-45(74)34(19-27(2)3)63-44(73)33(62-48(38)77)10-7-17-58-52(55)56/h6,9,12-16,23,27,32-40H,5,7-8,10-11,17-22,24-26H2,1-4H3,(H2,54,70)(H,59,78)(H,60,69)(H,61,71)(H,62,77)(H,63,73)(H,64,72)(H,65,75)(H,66,76)(H,67,74)(H,80,81)(H4,55,56,58)/t32-,33+,34-,35-,36-,37-,38+,39-,40+/m0/s1
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 2.40n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085755
PNG
(CHEMBL405781 | cyclo(1,1'-3)Ac-D-Asp (D-Ala)-D-Cpa...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)N[C@H](C)C(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C68H91ClN16O15/c1-36(2)29-49(61(94)79-48(14-9-27-74-68(71)72)67(100)85-28-10-15-55(85)66(99)76-37(3)57(70)90)80-63(96)52(33-42-16-21-43-11-6-7-12-44(43)30-42)82-62(95)51(32-41-19-24-46(88)25-20-41)83-65(98)54(35-86)84-60(93)47-13-8-26-73-59(92)50(31-40-17-22-45(69)23-18-40)81-64(97)53(77-39(5)87)34-56(89)75-38(4)58(91)78-47/h6-7,11-12,16-25,30,36-38,47-55,86,88H,8-10,13-15,26-29,31-35H2,1-5H3,(H2,70,90)(H,73,92)(H,75,89)(H,76,99)(H,77,87)(H,78,91)(H,79,94)(H,80,96)(H,81,97)(H,82,95)(H,83,98)(H,84,93)(H4,71,72,74)/t37?,38-,47-,48+,49-,50-,51+,52?,53?,54+,55-/m1/s1
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 2.40n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085714
PNG
(CHEMBL265169 | Cyclo (5-8) [Ac-D Nal, D Cpa, D Pal...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]1CCC(=O)Nc2ccc(C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc3cccnc3)NC1=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O)cc2
Show InChI InChI=1S/C63H79ClN14O14/c1-6-43(69-36(5)79)55(84)73-46(27-37-13-17-41(64)18-14-37)58(87)75-48(30-40-11-8-24-67-33-40)60(89)76-49(31-53(81)82)61(90)71-44-21-22-52(80)70-42-19-15-38(16-20-42)28-50(63(92)78-25-9-12-51(78)62(91)68-35(4)54(65)83)77-57(86)45(26-34(2)3)72-59(88)47(74-56(44)85)29-39-10-7-23-66-32-39/h7-8,10-11,13-20,23-24,32-35,43-51H,6,9,12,21-22,25-31H2,1-5H3,(H2,65,83)(H,68,91)(H,69,79)(H,70,80)(H,71,90)(H,72,88)(H,73,84)(H,74,85)(H,75,87)(H,76,89)(H,77,86)(H,81,82)/t35-,43-,44+,45-,46-,47+,48-,49-,50-,51+/m0/s1
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 3.30n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085749
PNG
(CHEMBL410999 | cyclo(1,1'-3)Ac-D-Asp (Ala)-D-Cpa-D...)
Show SMILES CC(C)C[C@@H](NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)C(CC(=O)NC(C)C(=O)N1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@@H]1C(=O)NC(C)C(N)=O
Show InChI InChI=1S/C68H91ClN16O15/c1-36(2)29-49(61(94)79-48(14-9-27-74-68(71)72)67(100)85-28-10-15-55(85)66(99)76-37(3)57(70)90)80-63(96)52(33-42-16-21-43-11-6-7-12-44(43)30-42)82-62(95)51(32-41-19-24-46(88)25-20-41)83-65(98)54(35-86)84-60(93)47-13-8-26-73-59(92)50(31-40-17-22-45(69)23-18-40)81-64(97)53(77-39(5)87)34-56(89)75-38(4)58(91)78-47/h6-7,11-12,16-25,30,36-38,47-55,86,88H,8-10,13-15,26-29,31-35H2,1-5H3,(H2,70,90)(H,73,92)(H,75,89)(H,76,99)(H,77,87)(H,78,91)(H,79,94)(H,80,96)(H,81,97)(H,82,95)(H,83,98)(H,84,93)(H4,71,72,74)/t37?,38?,47-,48+,49-,50-,51+,52?,53?,54+,55-/m1/s1
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 3.30n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay for rat Gonadotropin-releasing hormone receptor cells stably transfected in human HEK-293

J Med Chem 43: 797-806 (2000)


BindingDB Entry DOI: 10.7270/Q2DF6QD5
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085739
PNG
(CHEMBL438899 | Cyclo (5,5'-8) [Ac-D Nal, D Cpa, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]1CC(=O)NCC(=O)Nc2ccc(C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC1=O)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O)cc2
Show InChI InChI=1S/C59H77ClN14O15/c1-7-39(66-33(6)75)52(82)69-41(23-34-12-16-37(60)17-13-34)55(85)70-42(25-36-10-8-20-62-28-36)56(86)72-44(27-49(78)79)57(87)71-43-26-47(76)63-29-48(77)67-38-18-14-35(15-19-38)24-45(59(89)74-21-9-11-46(74)58(88)64-31(4)50(61)80)73-54(84)40(22-30(2)3)68-51(81)32(5)65-53(43)83/h8,10,12-20,28,30-32,39-46H,7,9,11,21-27,29H2,1-6H3,(H2,61,80)(H,63,76)(H,64,88)(H,65,83)(H,66,75)(H,67,77)(H,68,81)(H,69,82)(H,70,85)(H,71,87)(H,72,86)(H,73,84)(H,78,79)/t31-,32+,39-,40-,41-,42-,43+,44-,45-,46+/m0/s1
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 3.60n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)		BDBM50085736
PNG
(CHEMBL428266 | DiCyclo (4-10/5,5'-8) [Ac-D Nal, D ...)
Show SMILES CC[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccnc1)C(=O)N[C@H]1CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)C2CCNC(=O)[C@@H](CC)NC(=O)CC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC(C)C)C(=O)N2)C(N)=O
Show InChI InChI=1S/C60H87ClN18O14/c1-6-36-50(84)66-23-20-40-59(93)79-24-10-13-46(79)58(92)78-45(49(62)83)30-68-48(82)28-44(57(91)72-39(18-19-47(81)70-36)53(87)71-38(12-9-22-67-60(63)64)52(86)74-41(25-31(3)4)54(88)73-40)77-56(90)43(27-34-11-8-21-65-29-34)76-55(89)42(26-33-14-16-35(61)17-15-33)75-51(85)37(7-2)69-32(5)80/h8,11,14-17,21,29,31,36-46H,6-7,9-10,12-13,18-20,22-28,30H2,1-5H3,(H2,62,83)(H,66,84)(H,68,82)(H,69,80)(H,70,81)(H,71,87)(H,72,91)(H,73,88)(H,74,86)(H,75,85)(H,76,89)(H,77,90)(H,78,92)(H4,63,64,67)/t36-,37+,38+,39+,40?,41-,42+,43+,44+,45?,46+/m1/s1
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 4.20n/an/an/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Competitive radioligand binding assay, in human HEK-293 cells stably transfected with the rat Gonadotropin-releasing hormone receptor

J Med Chem 43: 784-96 (2000)


BindingDB Entry DOI: 10.7270/Q2J38RS2
More data for this
Ligand-Target Pair
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