Found 28 hits with Last Name = 'lapidot' and Initial = 't' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50374672
(CHEMBL271586)Show SMILES NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:29.30,wD:51.53,18.18,40.42,(30.64,-.68,;29.3,.09,;29.31,1.63,;27.97,-.68,;26.64,.1,;26.64,1.64,;27.98,2.4,;27.98,3.94,;25.3,3.95,;23.96,4.72,;23.96,6.26,;22.63,3.95,;21.3,4.72,;19.96,3.95,;19.96,2.41,;18.63,1.64,;17.29,2.41,;18.63,.1,;17.29,-.67,;15.96,.1,;14.63,-.67,;13.3,.11,;11.96,-.66,;11.96,-2.2,;13.31,-2.97,;14.63,-2.2,;17.29,-2.21,;15.96,-2.98,;18.63,-2.98,;18.63,-4.52,;17.29,-5.29,;17.29,-6.83,;15.95,-7.59,;15.95,-9.13,;17.29,-9.9,;18.63,-9.12,;18.62,-7.59,;19.96,-5.29,;19.96,-6.83,;21.3,-4.52,;22.63,-5.29,;22.63,-6.83,;23.96,-7.6,;23.96,-9.14,;25.3,-9.91,;25.3,-11.45,;26.63,-12.22,;23.96,-12.22,;23.96,-4.52,;25.3,-5.29,;23.96,-2.98,;25.3,-2.21,;26.63,-2.98,;28.17,-2.98,;29.08,-1.72,;30.54,-2.19,;30.53,-3.74,;31.67,-4.77,;31.35,-6.28,;29.88,-6.75,;28.74,-5.71,;29.07,-4.21,;25.3,-.67,;23.97,.1,)| Show InChI InChI=1S/C46H59N11O7/c47-39(58)29-57-24-12-23-50-40(59)20-9-10-21-41(60)53-36(25-30-13-3-1-4-14-30)43(62)55-37(26-31-15-5-2-6-16-31)44(63)54-35(19-11-22-51-46(48)49)42(61)56-38(45(57)64)27-32-28-52-34-18-8-7-17-33(32)34/h1-8,13-18,28,35-38,52H,9-12,19-27,29H2,(H2,47,58)(H,50,59)(H,53,60)(H,54,63)(H,55,62)(H,56,61)(H4,48,49,51)/t35-,36-,37+,38-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Displacement of [125I]NDP-alpha-MSH from MC4R |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50374671
(CHEMBL272660)Show SMILES NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:27.28,wD:16.16,49.51,38.40,(28.48,-20.35,;27.16,-19.57,;27.17,-18.03,;25.81,-20.32,;25.8,-21.86,;23.64,-21.92,;23.15,-20.32,;24.48,-19.55,;24.48,-18.01,;23.15,-17.24,;23.15,-15.7,;21.81,-18.01,;21.81,-19.55,;20.48,-20.32,;19.15,-19.55,;20.48,-21.86,;19.15,-22.63,;17.81,-21.86,;16.48,-22.63,;15.15,-21.85,;13.82,-22.62,;13.81,-24.16,;15.16,-24.93,;16.48,-24.16,;19.15,-24.17,;17.81,-24.94,;20.48,-24.94,;20.48,-26.48,;19.15,-27.25,;19.15,-28.79,;17.81,-29.56,;17.8,-31.09,;19.14,-31.87,;20.48,-31.09,;20.47,-29.55,;21.81,-27.25,;21.81,-28.79,;23.15,-26.48,;24.48,-27.25,;24.48,-28.79,;25.81,-29.56,;25.81,-31.1,;27.15,-31.87,;27.15,-33.41,;28.48,-34.18,;25.81,-34.18,;25.81,-26.48,;27.15,-27.25,;25.81,-24.94,;27.15,-24.17,;28.48,-24.94,;29.82,-24.17,;29.98,-22.63,;31.49,-22.31,;32.24,-23.66,;33.75,-23.99,;34.21,-25.46,;33.18,-26.59,;31.67,-26.26,;31.21,-24.8,;27.15,-22.63,;28.48,-21.86,)| Show InChI InChI=1S/C44H55N11O7/c45-37(56)27-55-22-10-21-48-38(57)18-19-39(58)51-34(23-28-11-3-1-4-12-28)41(60)53-35(24-29-13-5-2-6-14-29)42(61)52-33(17-9-20-49-44(46)47)40(59)54-36(43(55)62)25-30-26-50-32-16-8-7-15-31(30)32/h1-8,11-16,26,33-36,50H,9-10,17-25,27H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H,54,59)(H4,46,47,49)/t33-,34-,35+,36-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Displacement of [125I]NDP-alpha-MSH from MC4R |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50374673
(CHEMBL408398)Show SMILES NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:26.27,wD:15.15,48.50,37.39,(3.62,2.67,;2.29,1.89,;.96,2.65,;2.3,.35,;.97,-.43,;.99,1.1,;-.35,1.87,;-.35,3.41,;-1.68,4.18,;-1.68,5.72,;-3.01,3.41,;-3.01,1.87,;-4.35,1.1,;-5.68,1.87,;-4.35,-.44,;-5.68,-1.21,;-7.01,-.44,;-8.35,-1.21,;-9.68,-.43,;-11.01,-1.19,;-11.01,-2.74,;-9.67,-3.51,;-8.34,-2.73,;-5.68,-2.75,;-7.01,-3.52,;-4.35,-3.52,;-4.35,-5.06,;-5.68,-5.83,;-5.68,-7.37,;-7.02,-8.13,;-7.02,-9.67,;-5.69,-10.44,;-4.35,-9.66,;-4.36,-8.12,;-3.01,-5.83,;-3.01,-7.37,;-1.68,-5.06,;-.35,-5.83,;-.35,-7.37,;.99,-8.14,;.99,-9.68,;2.32,-10.45,;2.32,-11.99,;3.65,-12.76,;.99,-12.76,;.99,-5.06,;2.32,-5.83,;.99,-3.52,;2.32,-2.75,;3.65,-3.52,;4.99,-2.75,;5.16,-1.2,;6.66,-.89,;7.42,-2.23,;8.92,-2.56,;9.39,-4.03,;8.35,-5.17,;6.85,-4.84,;6.38,-3.37,;2.32,-1.21,;3.65,-.44,)| Show InChI InChI=1S/C43H53N11O7/c44-36(55)26-54-21-20-47-37(56)17-18-38(57)50-33(22-27-10-3-1-4-11-27)40(59)52-34(23-28-12-5-2-6-13-28)41(60)51-32(16-9-19-48-43(45)46)39(58)53-35(42(54)61)24-29-25-49-31-15-8-7-14-30(29)31/h1-8,10-15,25,32-35,49H,9,16-24,26H2,(H2,44,55)(H,47,56)(H,50,57)(H,51,60)(H,52,59)(H,53,58)(H4,45,46,48)/t32-,33-,34+,35-/m0/s1 | PDB
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UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Displacement of [125I]NDP-alpha-MSH from MC4R |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50374670
(CHEMBL270923)Show SMILES NC(=O)CN1CCNC(=O)c2ccccc2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:30.32,wD:52.55,19.20,41.44,(6.67,-17.07,;5.13,-17.07,;4.36,-15.74,;4.37,-18.41,;2.83,-18.41,;2.05,-17.08,;.51,-17.09,;-.25,-18.42,;-1.79,-18.43,;-2.56,-19.76,;-2.57,-17.1,;-1.81,-15.76,;-2.59,-14.43,;-4.14,-14.45,;-4.89,-15.78,;-4.11,-17.1,;-4.87,-18.43,;-6.41,-18.44,;-4.1,-19.76,;-5.43,-20.54,;-6.76,-19.76,;-8.09,-20.54,;-9.42,-19.75,;-10.76,-20.53,;-10.76,-22.07,;-9.41,-22.83,;-8.09,-22.06,;-5.43,-22.08,;-6.76,-22.84,;-4.1,-22.84,;-4.1,-24.38,;-5.43,-25.16,;-5.43,-26.7,;-6.77,-27.46,;-6.77,-28.99,;-5.43,-29.77,;-4.1,-28.99,;-4.1,-27.45,;-2.76,-25.16,;-2.76,-26.7,;-1.42,-24.38,;-.09,-25.16,;-.09,-26.7,;1.24,-27.46,;1.24,-29,;2.58,-29.78,;2.58,-31.32,;3.91,-32.08,;1.24,-32.08,;1.24,-24.38,;2.58,-25.16,;1.24,-22.84,;2.58,-22.08,;3.91,-22.84,;5.24,-22.08,;5.41,-20.53,;6.91,-20.22,;7.67,-21.56,;9.18,-21.89,;9.64,-23.36,;8.6,-24.49,;7.1,-24.16,;6.63,-22.7,;2.06,-19.75,;.52,-19.75,)| Show InChI InChI=1S/C47H53N11O7/c48-40(59)28-58-23-22-51-41(60)33-17-7-8-18-34(33)42(61)55-37(24-29-12-3-1-4-13-29)45(64)56-38(25-30-14-5-2-6-15-30)44(63)54-36(20-11-21-52-47(49)50)43(62)57-39(46(58)65)26-31-27-53-35-19-10-9-16-32(31)35/h1-10,12-19,27,36-39,53H,11,20-26,28H2,(H2,48,59)(H,51,60)(H,54,63)(H,55,61)(H,56,64)(H,57,62)(H4,49,50,52)/t36-,37-,38+,39-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Displacement of [125I]NDP-alpha-MSH from MC4R |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50374669
(CHEMBL406985)Show SMILES NC(=O)CN1CCNC(=O)CCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:27.28,wD:16.16,49.51,38.40,(13.37,-36.69,;12.04,-35.93,;12.04,-34.39,;10.72,-36.69,;10.72,-38.22,;8.06,-38.19,;8.05,-36.66,;9.38,-35.89,;9.37,-34.36,;10.7,-33.58,;8.04,-33.6,;6.71,-34.37,;6.71,-35.91,;5.38,-36.68,;4.04,-35.91,;5.38,-38.22,;4.04,-38.99,;2.71,-38.22,;1.37,-38.99,;.04,-38.21,;-1.29,-38.98,;-1.29,-40.52,;.05,-41.29,;1.38,-40.52,;4.04,-40.53,;2.71,-41.3,;5.38,-41.3,;5.38,-42.84,;4.04,-43.61,;4.04,-45.15,;2.7,-45.91,;2.7,-47.45,;4.04,-48.22,;5.38,-47.44,;5.37,-45.91,;6.71,-43.61,;6.71,-45.15,;8.04,-42.84,;9.38,-43.61,;9.38,-45.15,;10.71,-45.92,;10.71,-47.46,;12.05,-48.23,;12.05,-49.77,;13.38,-50.54,;10.71,-50.54,;10.71,-42.84,;12.05,-43.61,;10.71,-41.3,;12.05,-40.53,;13.38,-41.3,;14.72,-40.53,;14.88,-38.98,;16.39,-38.67,;17.14,-40.02,;18.64,-40.35,;19.12,-41.81,;18.08,-42.95,;16.57,-42.62,;16.11,-41.15,;12.05,-38.99,;13.38,-38.22,)| Show InChI InChI=1S/C44H55N11O7/c45-37(56)27-55-22-21-48-38(57)18-9-19-39(58)51-34(23-28-11-3-1-4-12-28)41(60)53-35(24-29-13-5-2-6-14-29)42(61)52-33(17-10-20-49-44(46)47)40(59)54-36(43(55)62)25-30-26-50-32-16-8-7-15-31(30)32/h1-8,11-16,26,33-36,50H,9-10,17-25,27H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H,54,59)(H4,46,47,49)/t33-,34-,35+,36-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50374672
(CHEMBL271586)Show SMILES NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:29.30,wD:51.53,18.18,40.42,(30.64,-.68,;29.3,.09,;29.31,1.63,;27.97,-.68,;26.64,.1,;26.64,1.64,;27.98,2.4,;27.98,3.94,;25.3,3.95,;23.96,4.72,;23.96,6.26,;22.63,3.95,;21.3,4.72,;19.96,3.95,;19.96,2.41,;18.63,1.64,;17.29,2.41,;18.63,.1,;17.29,-.67,;15.96,.1,;14.63,-.67,;13.3,.11,;11.96,-.66,;11.96,-2.2,;13.31,-2.97,;14.63,-2.2,;17.29,-2.21,;15.96,-2.98,;18.63,-2.98,;18.63,-4.52,;17.29,-5.29,;17.29,-6.83,;15.95,-7.59,;15.95,-9.13,;17.29,-9.9,;18.63,-9.12,;18.62,-7.59,;19.96,-5.29,;19.96,-6.83,;21.3,-4.52,;22.63,-5.29,;22.63,-6.83,;23.96,-7.6,;23.96,-9.14,;25.3,-9.91,;25.3,-11.45,;26.63,-12.22,;23.96,-12.22,;23.96,-4.52,;25.3,-5.29,;23.96,-2.98,;25.3,-2.21,;26.63,-2.98,;28.17,-2.98,;29.08,-1.72,;30.54,-2.19,;30.53,-3.74,;31.67,-4.77,;31.35,-6.28,;29.88,-6.75,;28.74,-5.71,;29.07,-4.21,;25.3,-.67,;23.97,.1,)| Show InChI InChI=1S/C46H59N11O7/c47-39(58)29-57-24-12-23-50-40(59)20-9-10-21-41(60)53-36(25-30-13-3-1-4-14-30)43(62)55-37(26-31-15-5-2-6-16-31)44(63)54-35(19-11-22-51-46(48)49)42(61)56-38(45(57)64)27-32-28-52-34-18-8-7-17-33(32)34/h1-8,13-18,28,35-38,52H,9-12,19-27,29H2,(H2,47,58)(H,50,59)(H,53,60)(H,54,63)(H,55,62)(H,56,61)(H4,48,49,51)/t35-,36-,37+,38-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 240 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50374673
(CHEMBL408398)Show SMILES NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:26.27,wD:15.15,48.50,37.39,(3.62,2.67,;2.29,1.89,;.96,2.65,;2.3,.35,;.97,-.43,;.99,1.1,;-.35,1.87,;-.35,3.41,;-1.68,4.18,;-1.68,5.72,;-3.01,3.41,;-3.01,1.87,;-4.35,1.1,;-5.68,1.87,;-4.35,-.44,;-5.68,-1.21,;-7.01,-.44,;-8.35,-1.21,;-9.68,-.43,;-11.01,-1.19,;-11.01,-2.74,;-9.67,-3.51,;-8.34,-2.73,;-5.68,-2.75,;-7.01,-3.52,;-4.35,-3.52,;-4.35,-5.06,;-5.68,-5.83,;-5.68,-7.37,;-7.02,-8.13,;-7.02,-9.67,;-5.69,-10.44,;-4.35,-9.66,;-4.36,-8.12,;-3.01,-5.83,;-3.01,-7.37,;-1.68,-5.06,;-.35,-5.83,;-.35,-7.37,;.99,-8.14,;.99,-9.68,;2.32,-10.45,;2.32,-11.99,;3.65,-12.76,;.99,-12.76,;.99,-5.06,;2.32,-5.83,;.99,-3.52,;2.32,-2.75,;3.65,-3.52,;4.99,-2.75,;5.16,-1.2,;6.66,-.89,;7.42,-2.23,;8.92,-2.56,;9.39,-4.03,;8.35,-5.17,;6.85,-4.84,;6.38,-3.37,;2.32,-1.21,;3.65,-.44,)| Show InChI InChI=1S/C43H53N11O7/c44-36(55)26-54-21-20-47-37(56)17-18-38(57)50-33(22-27-10-3-1-4-11-27)40(59)52-34(23-28-12-5-2-6-13-28)41(60)51-32(16-9-19-48-43(45)46)39(58)53-35(42(54)61)24-29-25-49-31-15-8-7-14-30(29)31/h1-8,10-15,25,32-35,49H,9,16-24,26H2,(H2,44,55)(H,47,56)(H,50,57)(H,51,60)(H,52,59)(H,53,58)(H4,45,46,48)/t32-,33-,34+,35-/m0/s1 | KEGG
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 64 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Mus musculus) | BDBM50374673
(CHEMBL408398)Show SMILES NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:26.27,wD:15.15,48.50,37.39,(3.62,2.67,;2.29,1.89,;.96,2.65,;2.3,.35,;.97,-.43,;.99,1.1,;-.35,1.87,;-.35,3.41,;-1.68,4.18,;-1.68,5.72,;-3.01,3.41,;-3.01,1.87,;-4.35,1.1,;-5.68,1.87,;-4.35,-.44,;-5.68,-1.21,;-7.01,-.44,;-8.35,-1.21,;-9.68,-.43,;-11.01,-1.19,;-11.01,-2.74,;-9.67,-3.51,;-8.34,-2.73,;-5.68,-2.75,;-7.01,-3.52,;-4.35,-3.52,;-4.35,-5.06,;-5.68,-5.83,;-5.68,-7.37,;-7.02,-8.13,;-7.02,-9.67,;-5.69,-10.44,;-4.35,-9.66,;-4.36,-8.12,;-3.01,-5.83,;-3.01,-7.37,;-1.68,-5.06,;-.35,-5.83,;-.35,-7.37,;.99,-8.14,;.99,-9.68,;2.32,-10.45,;2.32,-11.99,;3.65,-12.76,;.99,-12.76,;.99,-5.06,;2.32,-5.83,;.99,-3.52,;2.32,-2.75,;3.65,-3.52,;4.99,-2.75,;5.16,-1.2,;6.66,-.89,;7.42,-2.23,;8.92,-2.56,;9.39,-4.03,;8.35,-5.17,;6.85,-4.84,;6.38,-3.37,;2.32,-1.21,;3.65,-.44,)| Show InChI InChI=1S/C43H53N11O7/c44-36(55)26-54-21-20-47-37(56)17-18-38(57)50-33(22-27-10-3-1-4-11-27)40(59)52-34(23-28-12-5-2-6-13-28)41(60)51-32(16-9-19-48-43(45)46)39(58)53-35(42(54)61)24-29-25-49-31-15-8-7-14-30(29)31/h1-8,10-15,25,32-35,49H,9,16-24,26H2,(H2,44,55)(H,47,56)(H,50,57)(H,51,60)(H,52,59)(H,53,58)(H4,45,46,48)/t32-,33-,34+,35-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 770 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50374673
(CHEMBL408398)Show SMILES NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:26.27,wD:15.15,48.50,37.39,(3.62,2.67,;2.29,1.89,;.96,2.65,;2.3,.35,;.97,-.43,;.99,1.1,;-.35,1.87,;-.35,3.41,;-1.68,4.18,;-1.68,5.72,;-3.01,3.41,;-3.01,1.87,;-4.35,1.1,;-5.68,1.87,;-4.35,-.44,;-5.68,-1.21,;-7.01,-.44,;-8.35,-1.21,;-9.68,-.43,;-11.01,-1.19,;-11.01,-2.74,;-9.67,-3.51,;-8.34,-2.73,;-5.68,-2.75,;-7.01,-3.52,;-4.35,-3.52,;-4.35,-5.06,;-5.68,-5.83,;-5.68,-7.37,;-7.02,-8.13,;-7.02,-9.67,;-5.69,-10.44,;-4.35,-9.66,;-4.36,-8.12,;-3.01,-5.83,;-3.01,-7.37,;-1.68,-5.06,;-.35,-5.83,;-.35,-7.37,;.99,-8.14,;.99,-9.68,;2.32,-10.45,;2.32,-11.99,;3.65,-12.76,;.99,-12.76,;.99,-5.06,;2.32,-5.83,;.99,-3.52,;2.32,-2.75,;3.65,-3.52,;4.99,-2.75,;5.16,-1.2,;6.66,-.89,;7.42,-2.23,;8.92,-2.56,;9.39,-4.03,;8.35,-5.17,;6.85,-4.84,;6.38,-3.37,;2.32,-1.21,;3.65,-.44,)| Show InChI InChI=1S/C43H53N11O7/c44-36(55)26-54-21-20-47-37(56)17-18-38(57)50-33(22-27-10-3-1-4-11-27)40(59)52-34(23-28-12-5-2-6-13-28)41(60)51-32(16-9-19-48-43(45)46)39(58)53-35(42(54)61)24-29-25-49-31-15-8-7-14-30(29)31/h1-8,10-15,25,32-35,49H,9,16-24,26H2,(H2,44,55)(H,47,56)(H,50,57)(H,51,60)(H,52,59)(H,53,58)(H4,45,46,48)/t32-,33-,34+,35-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50374673
(CHEMBL408398)Show SMILES NC(=O)CN1CCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:26.27,wD:15.15,48.50,37.39,(3.62,2.67,;2.29,1.89,;.96,2.65,;2.3,.35,;.97,-.43,;.99,1.1,;-.35,1.87,;-.35,3.41,;-1.68,4.18,;-1.68,5.72,;-3.01,3.41,;-3.01,1.87,;-4.35,1.1,;-5.68,1.87,;-4.35,-.44,;-5.68,-1.21,;-7.01,-.44,;-8.35,-1.21,;-9.68,-.43,;-11.01,-1.19,;-11.01,-2.74,;-9.67,-3.51,;-8.34,-2.73,;-5.68,-2.75,;-7.01,-3.52,;-4.35,-3.52,;-4.35,-5.06,;-5.68,-5.83,;-5.68,-7.37,;-7.02,-8.13,;-7.02,-9.67,;-5.69,-10.44,;-4.35,-9.66,;-4.36,-8.12,;-3.01,-5.83,;-3.01,-7.37,;-1.68,-5.06,;-.35,-5.83,;-.35,-7.37,;.99,-8.14,;.99,-9.68,;2.32,-10.45,;2.32,-11.99,;3.65,-12.76,;.99,-12.76,;.99,-5.06,;2.32,-5.83,;.99,-3.52,;2.32,-2.75,;3.65,-3.52,;4.99,-2.75,;5.16,-1.2,;6.66,-.89,;7.42,-2.23,;8.92,-2.56,;9.39,-4.03,;8.35,-5.17,;6.85,-4.84,;6.38,-3.37,;2.32,-1.21,;3.65,-.44,)| Show InChI InChI=1S/C43H53N11O7/c44-36(55)26-54-21-20-47-37(56)17-18-38(57)50-33(22-27-10-3-1-4-11-27)40(59)52-34(23-28-12-5-2-6-13-28)41(60)51-32(16-9-19-48-43(45)46)39(58)53-35(42(54)61)24-29-25-49-31-15-8-7-14-30(29)31/h1-8,10-15,25,32-35,49H,9,16-24,26H2,(H2,44,55)(H,47,56)(H,50,57)(H,51,60)(H,52,59)(H,53,58)(H4,45,46,48)/t32-,33-,34+,35-/m0/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Mus musculus) | BDBM50121900
(Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pr...)Show SMILES CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0630 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Mus musculus) | BDBM50374671
(CHEMBL272660)Show SMILES NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:27.28,wD:16.16,49.51,38.40,(28.48,-20.35,;27.16,-19.57,;27.17,-18.03,;25.81,-20.32,;25.8,-21.86,;23.64,-21.92,;23.15,-20.32,;24.48,-19.55,;24.48,-18.01,;23.15,-17.24,;23.15,-15.7,;21.81,-18.01,;21.81,-19.55,;20.48,-20.32,;19.15,-19.55,;20.48,-21.86,;19.15,-22.63,;17.81,-21.86,;16.48,-22.63,;15.15,-21.85,;13.82,-22.62,;13.81,-24.16,;15.16,-24.93,;16.48,-24.16,;19.15,-24.17,;17.81,-24.94,;20.48,-24.94,;20.48,-26.48,;19.15,-27.25,;19.15,-28.79,;17.81,-29.56,;17.8,-31.09,;19.14,-31.87,;20.48,-31.09,;20.47,-29.55,;21.81,-27.25,;21.81,-28.79,;23.15,-26.48,;24.48,-27.25,;24.48,-28.79,;25.81,-29.56,;25.81,-31.1,;27.15,-31.87,;27.15,-33.41,;28.48,-34.18,;25.81,-34.18,;25.81,-26.48,;27.15,-27.25,;25.81,-24.94,;27.15,-24.17,;28.48,-24.94,;29.82,-24.17,;29.98,-22.63,;31.49,-22.31,;32.24,-23.66,;33.75,-23.99,;34.21,-25.46,;33.18,-26.59,;31.67,-26.26,;31.21,-24.8,;27.15,-22.63,;28.48,-21.86,)| Show InChI InChI=1S/C44H55N11O7/c45-37(56)27-55-22-10-21-48-38(57)18-19-39(58)51-34(23-28-11-3-1-4-12-28)41(60)53-35(24-29-13-5-2-6-14-29)42(61)52-33(17-9-20-49-44(46)47)40(59)54-36(43(55)62)25-30-26-50-32-16-8-7-15-31(30)32/h1-8,11-16,26,33-36,50H,9-10,17-25,27H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H,54,59)(H4,46,47,49)/t33-,34-,35+,36-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.26E+3 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Mus musculus) | BDBM50374670
(CHEMBL270923)Show SMILES NC(=O)CN1CCNC(=O)c2ccccc2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:30.32,wD:52.55,19.20,41.44,(6.67,-17.07,;5.13,-17.07,;4.36,-15.74,;4.37,-18.41,;2.83,-18.41,;2.05,-17.08,;.51,-17.09,;-.25,-18.42,;-1.79,-18.43,;-2.56,-19.76,;-2.57,-17.1,;-1.81,-15.76,;-2.59,-14.43,;-4.14,-14.45,;-4.89,-15.78,;-4.11,-17.1,;-4.87,-18.43,;-6.41,-18.44,;-4.1,-19.76,;-5.43,-20.54,;-6.76,-19.76,;-8.09,-20.54,;-9.42,-19.75,;-10.76,-20.53,;-10.76,-22.07,;-9.41,-22.83,;-8.09,-22.06,;-5.43,-22.08,;-6.76,-22.84,;-4.1,-22.84,;-4.1,-24.38,;-5.43,-25.16,;-5.43,-26.7,;-6.77,-27.46,;-6.77,-28.99,;-5.43,-29.77,;-4.1,-28.99,;-4.1,-27.45,;-2.76,-25.16,;-2.76,-26.7,;-1.42,-24.38,;-.09,-25.16,;-.09,-26.7,;1.24,-27.46,;1.24,-29,;2.58,-29.78,;2.58,-31.32,;3.91,-32.08,;1.24,-32.08,;1.24,-24.38,;2.58,-25.16,;1.24,-22.84,;2.58,-22.08,;3.91,-22.84,;5.24,-22.08,;5.41,-20.53,;6.91,-20.22,;7.67,-21.56,;9.18,-21.89,;9.64,-23.36,;8.6,-24.49,;7.1,-24.16,;6.63,-22.7,;2.06,-19.75,;.52,-19.75,)| Show InChI InChI=1S/C47H53N11O7/c48-40(59)28-58-23-22-51-41(60)33-17-7-8-18-34(33)42(61)55-37(24-29-12-3-1-4-13-29)45(64)56-38(25-30-14-5-2-6-15-30)44(63)54-36(20-11-21-52-47(49)50)43(62)57-39(46(58)65)26-31-27-53-35-19-10-9-16-32(31)35/h1-10,12-19,27,36-39,53H,11,20-26,28H2,(H2,48,59)(H,51,60)(H,54,63)(H,55,61)(H,56,64)(H,57,62)(H4,49,50,52)/t36-,37-,38+,39-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.05E+4 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Mus musculus) | BDBM50374672
(CHEMBL271586)Show SMILES NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:29.30,wD:51.53,18.18,40.42,(30.64,-.68,;29.3,.09,;29.31,1.63,;27.97,-.68,;26.64,.1,;26.64,1.64,;27.98,2.4,;27.98,3.94,;25.3,3.95,;23.96,4.72,;23.96,6.26,;22.63,3.95,;21.3,4.72,;19.96,3.95,;19.96,2.41,;18.63,1.64,;17.29,2.41,;18.63,.1,;17.29,-.67,;15.96,.1,;14.63,-.67,;13.3,.11,;11.96,-.66,;11.96,-2.2,;13.31,-2.97,;14.63,-2.2,;17.29,-2.21,;15.96,-2.98,;18.63,-2.98,;18.63,-4.52,;17.29,-5.29,;17.29,-6.83,;15.95,-7.59,;15.95,-9.13,;17.29,-9.9,;18.63,-9.12,;18.62,-7.59,;19.96,-5.29,;19.96,-6.83,;21.3,-4.52,;22.63,-5.29,;22.63,-6.83,;23.96,-7.6,;23.96,-9.14,;25.3,-9.91,;25.3,-11.45,;26.63,-12.22,;23.96,-12.22,;23.96,-4.52,;25.3,-5.29,;23.96,-2.98,;25.3,-2.21,;26.63,-2.98,;28.17,-2.98,;29.08,-1.72,;30.54,-2.19,;30.53,-3.74,;31.67,-4.77,;31.35,-6.28,;29.88,-6.75,;28.74,-5.71,;29.07,-4.21,;25.3,-.67,;23.97,.1,)| Show InChI InChI=1S/C46H59N11O7/c47-39(58)29-57-24-12-23-50-40(59)20-9-10-21-41(60)53-36(25-30-13-3-1-4-14-30)43(62)55-37(26-31-15-5-2-6-16-31)44(63)54-35(19-11-22-51-46(48)49)42(61)56-38(45(57)64)27-32-28-52-34-18-8-7-17-33(32)34/h1-8,13-18,28,35-38,52H,9-12,19-27,29H2,(H2,47,58)(H,50,59)(H,53,60)(H,54,63)(H,55,62)(H,56,61)(H4,48,49,51)/t35-,36-,37+,38-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.75E+3 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50374669
(CHEMBL406985)Show SMILES NC(=O)CN1CCNC(=O)CCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:27.28,wD:16.16,49.51,38.40,(13.37,-36.69,;12.04,-35.93,;12.04,-34.39,;10.72,-36.69,;10.72,-38.22,;8.06,-38.19,;8.05,-36.66,;9.38,-35.89,;9.37,-34.36,;10.7,-33.58,;8.04,-33.6,;6.71,-34.37,;6.71,-35.91,;5.38,-36.68,;4.04,-35.91,;5.38,-38.22,;4.04,-38.99,;2.71,-38.22,;1.37,-38.99,;.04,-38.21,;-1.29,-38.98,;-1.29,-40.52,;.05,-41.29,;1.38,-40.52,;4.04,-40.53,;2.71,-41.3,;5.38,-41.3,;5.38,-42.84,;4.04,-43.61,;4.04,-45.15,;2.7,-45.91,;2.7,-47.45,;4.04,-48.22,;5.38,-47.44,;5.37,-45.91,;6.71,-43.61,;6.71,-45.15,;8.04,-42.84,;9.38,-43.61,;9.38,-45.15,;10.71,-45.92,;10.71,-47.46,;12.05,-48.23,;12.05,-49.77,;13.38,-50.54,;10.71,-50.54,;10.71,-42.84,;12.05,-43.61,;10.71,-41.3,;12.05,-40.53,;13.38,-41.3,;14.72,-40.53,;14.88,-38.98,;16.39,-38.67,;17.14,-40.02,;18.64,-40.35,;19.12,-41.81,;18.08,-42.95,;16.57,-42.62,;16.11,-41.15,;12.05,-38.99,;13.38,-38.22,)| Show InChI InChI=1S/C44H55N11O7/c45-37(56)27-55-22-21-48-38(57)18-9-19-39(58)51-34(23-28-11-3-1-4-12-28)41(60)53-35(24-29-13-5-2-6-14-29)42(61)52-33(17-10-20-49-44(46)47)40(59)54-36(43(55)62)25-30-26-50-32-16-8-7-15-31(30)32/h1-8,11-16,26,33-36,50H,9-10,17-25,27H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H,54,59)(H4,46,47,49)/t33-,34-,35+,36-/m0/s1 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50374671
(CHEMBL272660)Show SMILES NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:27.28,wD:16.16,49.51,38.40,(28.48,-20.35,;27.16,-19.57,;27.17,-18.03,;25.81,-20.32,;25.8,-21.86,;23.64,-21.92,;23.15,-20.32,;24.48,-19.55,;24.48,-18.01,;23.15,-17.24,;23.15,-15.7,;21.81,-18.01,;21.81,-19.55,;20.48,-20.32,;19.15,-19.55,;20.48,-21.86,;19.15,-22.63,;17.81,-21.86,;16.48,-22.63,;15.15,-21.85,;13.82,-22.62,;13.81,-24.16,;15.16,-24.93,;16.48,-24.16,;19.15,-24.17,;17.81,-24.94,;20.48,-24.94,;20.48,-26.48,;19.15,-27.25,;19.15,-28.79,;17.81,-29.56,;17.8,-31.09,;19.14,-31.87,;20.48,-31.09,;20.47,-29.55,;21.81,-27.25,;21.81,-28.79,;23.15,-26.48,;24.48,-27.25,;24.48,-28.79,;25.81,-29.56,;25.81,-31.1,;27.15,-31.87,;27.15,-33.41,;28.48,-34.18,;25.81,-34.18,;25.81,-26.48,;27.15,-27.25,;25.81,-24.94,;27.15,-24.17,;28.48,-24.94,;29.82,-24.17,;29.98,-22.63,;31.49,-22.31,;32.24,-23.66,;33.75,-23.99,;34.21,-25.46,;33.18,-26.59,;31.67,-26.26,;31.21,-24.8,;27.15,-22.63,;28.48,-21.86,)| Show InChI InChI=1S/C44H55N11O7/c45-37(56)27-55-22-10-21-48-38(57)18-19-39(58)51-34(23-28-11-3-1-4-12-28)41(60)53-35(24-29-13-5-2-6-14-29)42(61)52-33(17-9-20-49-44(46)47)40(59)54-36(43(55)62)25-30-26-50-32-16-8-7-15-31(30)32/h1-8,11-16,26,33-36,50H,9-10,17-25,27H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H,54,59)(H4,46,47,49)/t33-,34-,35+,36-/m0/s1 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50374672
(CHEMBL271586)Show SMILES NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:29.30,wD:51.53,18.18,40.42,(30.64,-.68,;29.3,.09,;29.31,1.63,;27.97,-.68,;26.64,.1,;26.64,1.64,;27.98,2.4,;27.98,3.94,;25.3,3.95,;23.96,4.72,;23.96,6.26,;22.63,3.95,;21.3,4.72,;19.96,3.95,;19.96,2.41,;18.63,1.64,;17.29,2.41,;18.63,.1,;17.29,-.67,;15.96,.1,;14.63,-.67,;13.3,.11,;11.96,-.66,;11.96,-2.2,;13.31,-2.97,;14.63,-2.2,;17.29,-2.21,;15.96,-2.98,;18.63,-2.98,;18.63,-4.52,;17.29,-5.29,;17.29,-6.83,;15.95,-7.59,;15.95,-9.13,;17.29,-9.9,;18.63,-9.12,;18.62,-7.59,;19.96,-5.29,;19.96,-6.83,;21.3,-4.52,;22.63,-5.29,;22.63,-6.83,;23.96,-7.6,;23.96,-9.14,;25.3,-9.91,;25.3,-11.45,;26.63,-12.22,;23.96,-12.22,;23.96,-4.52,;25.3,-5.29,;23.96,-2.98,;25.3,-2.21,;26.63,-2.98,;28.17,-2.98,;29.08,-1.72,;30.54,-2.19,;30.53,-3.74,;31.67,-4.77,;31.35,-6.28,;29.88,-6.75,;28.74,-5.71,;29.07,-4.21,;25.3,-.67,;23.97,.1,)| Show InChI InChI=1S/C46H59N11O7/c47-39(58)29-57-24-12-23-50-40(59)20-9-10-21-41(60)53-36(25-30-13-3-1-4-14-30)43(62)55-37(26-31-15-5-2-6-16-31)44(63)54-35(19-11-22-51-46(48)49)42(61)56-38(45(57)64)27-32-28-52-34-18-8-7-17-33(32)34/h1-8,13-18,28,35-38,52H,9-12,19-27,29H2,(H2,47,58)(H,50,59)(H,53,60)(H,54,63)(H,55,62)(H,56,61)(H4,48,49,51)/t35-,36-,37+,38-/m0/s1 | PDB
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UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50121900
(Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pr...)Show SMILES CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0780 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50374669
(CHEMBL406985)Show SMILES NC(=O)CN1CCNC(=O)CCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:27.28,wD:16.16,49.51,38.40,(13.37,-36.69,;12.04,-35.93,;12.04,-34.39,;10.72,-36.69,;10.72,-38.22,;8.06,-38.19,;8.05,-36.66,;9.38,-35.89,;9.37,-34.36,;10.7,-33.58,;8.04,-33.6,;6.71,-34.37,;6.71,-35.91,;5.38,-36.68,;4.04,-35.91,;5.38,-38.22,;4.04,-38.99,;2.71,-38.22,;1.37,-38.99,;.04,-38.21,;-1.29,-38.98,;-1.29,-40.52,;.05,-41.29,;1.38,-40.52,;4.04,-40.53,;2.71,-41.3,;5.38,-41.3,;5.38,-42.84,;4.04,-43.61,;4.04,-45.15,;2.7,-45.91,;2.7,-47.45,;4.04,-48.22,;5.38,-47.44,;5.37,-45.91,;6.71,-43.61,;6.71,-45.15,;8.04,-42.84,;9.38,-43.61,;9.38,-45.15,;10.71,-45.92,;10.71,-47.46,;12.05,-48.23,;12.05,-49.77,;13.38,-50.54,;10.71,-50.54,;10.71,-42.84,;12.05,-43.61,;10.71,-41.3,;12.05,-40.53,;13.38,-41.3,;14.72,-40.53,;14.88,-38.98,;16.39,-38.67,;17.14,-40.02,;18.64,-40.35,;19.12,-41.81,;18.08,-42.95,;16.57,-42.62,;16.11,-41.15,;12.05,-38.99,;13.38,-38.22,)| Show InChI InChI=1S/C44H55N11O7/c45-37(56)27-55-22-21-48-38(57)18-9-19-39(58)51-34(23-28-11-3-1-4-12-28)41(60)53-35(24-29-13-5-2-6-14-29)42(61)52-33(17-10-20-49-44(46)47)40(59)54-36(43(55)62)25-30-26-50-32-16-8-7-15-31(30)32/h1-8,11-16,26,33-36,50H,9-10,17-25,27H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H,54,59)(H4,46,47,49)/t33-,34-,35+,36-/m0/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50374670
(CHEMBL270923)Show SMILES NC(=O)CN1CCNC(=O)c2ccccc2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:30.32,wD:52.55,19.20,41.44,(6.67,-17.07,;5.13,-17.07,;4.36,-15.74,;4.37,-18.41,;2.83,-18.41,;2.05,-17.08,;.51,-17.09,;-.25,-18.42,;-1.79,-18.43,;-2.56,-19.76,;-2.57,-17.1,;-1.81,-15.76,;-2.59,-14.43,;-4.14,-14.45,;-4.89,-15.78,;-4.11,-17.1,;-4.87,-18.43,;-6.41,-18.44,;-4.1,-19.76,;-5.43,-20.54,;-6.76,-19.76,;-8.09,-20.54,;-9.42,-19.75,;-10.76,-20.53,;-10.76,-22.07,;-9.41,-22.83,;-8.09,-22.06,;-5.43,-22.08,;-6.76,-22.84,;-4.1,-22.84,;-4.1,-24.38,;-5.43,-25.16,;-5.43,-26.7,;-6.77,-27.46,;-6.77,-28.99,;-5.43,-29.77,;-4.1,-28.99,;-4.1,-27.45,;-2.76,-25.16,;-2.76,-26.7,;-1.42,-24.38,;-.09,-25.16,;-.09,-26.7,;1.24,-27.46,;1.24,-29,;2.58,-29.78,;2.58,-31.32,;3.91,-32.08,;1.24,-32.08,;1.24,-24.38,;2.58,-25.16,;1.24,-22.84,;2.58,-22.08,;3.91,-22.84,;5.24,-22.08,;5.41,-20.53,;6.91,-20.22,;7.67,-21.56,;9.18,-21.89,;9.64,-23.36,;8.6,-24.49,;7.1,-24.16,;6.63,-22.7,;2.06,-19.75,;.52,-19.75,)| Show InChI InChI=1S/C47H53N11O7/c48-40(59)28-58-23-22-51-41(60)33-17-7-8-18-34(33)42(61)55-37(24-29-12-3-1-4-13-29)45(64)56-38(25-30-14-5-2-6-15-30)44(63)54-36(20-11-21-52-47(49)50)43(62)57-39(46(58)65)26-31-27-53-35-19-10-9-16-32(31)35/h1-10,12-19,27,36-39,53H,11,20-26,28H2,(H2,48,59)(H,51,60)(H,54,63)(H,55,61)(H,56,64)(H,57,62)(H4,49,50,52)/t36-,37-,38+,39-/m0/s1 | UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 390 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50374672
(CHEMBL271586)Show SMILES NC(=O)CN1CCCNC(=O)CCCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:29.30,wD:51.53,18.18,40.42,(30.64,-.68,;29.3,.09,;29.31,1.63,;27.97,-.68,;26.64,.1,;26.64,1.64,;27.98,2.4,;27.98,3.94,;25.3,3.95,;23.96,4.72,;23.96,6.26,;22.63,3.95,;21.3,4.72,;19.96,3.95,;19.96,2.41,;18.63,1.64,;17.29,2.41,;18.63,.1,;17.29,-.67,;15.96,.1,;14.63,-.67,;13.3,.11,;11.96,-.66,;11.96,-2.2,;13.31,-2.97,;14.63,-2.2,;17.29,-2.21,;15.96,-2.98,;18.63,-2.98,;18.63,-4.52,;17.29,-5.29,;17.29,-6.83,;15.95,-7.59,;15.95,-9.13,;17.29,-9.9,;18.63,-9.12,;18.62,-7.59,;19.96,-5.29,;19.96,-6.83,;21.3,-4.52,;22.63,-5.29,;22.63,-6.83,;23.96,-7.6,;23.96,-9.14,;25.3,-9.91,;25.3,-11.45,;26.63,-12.22,;23.96,-12.22,;23.96,-4.52,;25.3,-5.29,;23.96,-2.98,;25.3,-2.21,;26.63,-2.98,;28.17,-2.98,;29.08,-1.72,;30.54,-2.19,;30.53,-3.74,;31.67,-4.77,;31.35,-6.28,;29.88,-6.75,;28.74,-5.71,;29.07,-4.21,;25.3,-.67,;23.97,.1,)| Show InChI InChI=1S/C46H59N11O7/c47-39(58)29-57-24-12-23-50-40(59)20-9-10-21-41(60)53-36(25-30-13-3-1-4-14-30)43(62)55-37(26-31-15-5-2-6-16-31)44(63)54-35(19-11-22-51-46(48)49)42(61)56-38(45(57)64)27-32-28-52-34-18-8-7-17-33(32)34/h1-8,13-18,28,35-38,52H,9-12,19-27,29H2,(H2,47,58)(H,50,59)(H,53,60)(H,54,63)(H,55,62)(H,56,61)(H4,48,49,51)/t35-,36-,37+,38-/m0/s1 | UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50121900
(Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pr...)Show SMILES CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.00800 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50374671
(CHEMBL272660)Show SMILES NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:27.28,wD:16.16,49.51,38.40,(28.48,-20.35,;27.16,-19.57,;27.17,-18.03,;25.81,-20.32,;25.8,-21.86,;23.64,-21.92,;23.15,-20.32,;24.48,-19.55,;24.48,-18.01,;23.15,-17.24,;23.15,-15.7,;21.81,-18.01,;21.81,-19.55,;20.48,-20.32,;19.15,-19.55,;20.48,-21.86,;19.15,-22.63,;17.81,-21.86,;16.48,-22.63,;15.15,-21.85,;13.82,-22.62,;13.81,-24.16,;15.16,-24.93,;16.48,-24.16,;19.15,-24.17,;17.81,-24.94,;20.48,-24.94,;20.48,-26.48,;19.15,-27.25,;19.15,-28.79,;17.81,-29.56,;17.8,-31.09,;19.14,-31.87,;20.48,-31.09,;20.47,-29.55,;21.81,-27.25,;21.81,-28.79,;23.15,-26.48,;24.48,-27.25,;24.48,-28.79,;25.81,-29.56,;25.81,-31.1,;27.15,-31.87,;27.15,-33.41,;28.48,-34.18,;25.81,-34.18,;25.81,-26.48,;27.15,-27.25,;25.81,-24.94,;27.15,-24.17,;28.48,-24.94,;29.82,-24.17,;29.98,-22.63,;31.49,-22.31,;32.24,-23.66,;33.75,-23.99,;34.21,-25.46,;33.18,-26.59,;31.67,-26.26,;31.21,-24.8,;27.15,-22.63,;28.48,-21.86,)| Show InChI InChI=1S/C44H55N11O7/c45-37(56)27-55-22-10-21-48-38(57)18-19-39(58)51-34(23-28-11-3-1-4-12-28)41(60)53-35(24-29-13-5-2-6-14-29)42(61)52-33(17-9-20-49-44(46)47)40(59)54-36(43(55)62)25-30-26-50-32-16-8-7-15-31(30)32/h1-8,11-16,26,33-36,50H,9-10,17-25,27H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H,54,59)(H4,46,47,49)/t33-,34-,35+,36-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5
(Mus musculus (Mouse)) | BDBM50374671
(CHEMBL272660)Show SMILES NC(=O)CN1CCCNC(=O)CCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:27.28,wD:16.16,49.51,38.40,(28.48,-20.35,;27.16,-19.57,;27.17,-18.03,;25.81,-20.32,;25.8,-21.86,;23.64,-21.92,;23.15,-20.32,;24.48,-19.55,;24.48,-18.01,;23.15,-17.24,;23.15,-15.7,;21.81,-18.01,;21.81,-19.55,;20.48,-20.32,;19.15,-19.55,;20.48,-21.86,;19.15,-22.63,;17.81,-21.86,;16.48,-22.63,;15.15,-21.85,;13.82,-22.62,;13.81,-24.16,;15.16,-24.93,;16.48,-24.16,;19.15,-24.17,;17.81,-24.94,;20.48,-24.94,;20.48,-26.48,;19.15,-27.25,;19.15,-28.79,;17.81,-29.56,;17.8,-31.09,;19.14,-31.87,;20.48,-31.09,;20.47,-29.55,;21.81,-27.25,;21.81,-28.79,;23.15,-26.48,;24.48,-27.25,;24.48,-28.79,;25.81,-29.56,;25.81,-31.1,;27.15,-31.87,;27.15,-33.41,;28.48,-34.18,;25.81,-34.18,;25.81,-26.48,;27.15,-27.25,;25.81,-24.94,;27.15,-24.17,;28.48,-24.94,;29.82,-24.17,;29.98,-22.63,;31.49,-22.31,;32.24,-23.66,;33.75,-23.99,;34.21,-25.46,;33.18,-26.59,;31.67,-26.26,;31.21,-24.8,;27.15,-22.63,;28.48,-21.86,)| Show InChI InChI=1S/C44H55N11O7/c45-37(56)27-55-22-10-21-48-38(57)18-19-39(58)51-34(23-28-11-3-1-4-12-28)41(60)53-35(24-29-13-5-2-6-14-29)42(61)52-33(17-9-20-49-44(46)47)40(59)54-36(43(55)62)25-30-26-50-32-16-8-7-15-31(30)32/h1-8,11-16,26,33-36,50H,9-10,17-25,27H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H,54,59)(H4,46,47,49)/t33-,34-,35+,36-/m0/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC5R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50374670
(CHEMBL270923)Show SMILES NC(=O)CN1CCNC(=O)c2ccccc2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:30.32,wD:52.55,19.20,41.44,(6.67,-17.07,;5.13,-17.07,;4.36,-15.74,;4.37,-18.41,;2.83,-18.41,;2.05,-17.08,;.51,-17.09,;-.25,-18.42,;-1.79,-18.43,;-2.56,-19.76,;-2.57,-17.1,;-1.81,-15.76,;-2.59,-14.43,;-4.14,-14.45,;-4.89,-15.78,;-4.11,-17.1,;-4.87,-18.43,;-6.41,-18.44,;-4.1,-19.76,;-5.43,-20.54,;-6.76,-19.76,;-8.09,-20.54,;-9.42,-19.75,;-10.76,-20.53,;-10.76,-22.07,;-9.41,-22.83,;-8.09,-22.06,;-5.43,-22.08,;-6.76,-22.84,;-4.1,-22.84,;-4.1,-24.38,;-5.43,-25.16,;-5.43,-26.7,;-6.77,-27.46,;-6.77,-28.99,;-5.43,-29.77,;-4.1,-28.99,;-4.1,-27.45,;-2.76,-25.16,;-2.76,-26.7,;-1.42,-24.38,;-.09,-25.16,;-.09,-26.7,;1.24,-27.46,;1.24,-29,;2.58,-29.78,;2.58,-31.32,;3.91,-32.08,;1.24,-32.08,;1.24,-24.38,;2.58,-25.16,;1.24,-22.84,;2.58,-22.08,;3.91,-22.84,;5.24,-22.08,;5.41,-20.53,;6.91,-20.22,;7.67,-21.56,;9.18,-21.89,;9.64,-23.36,;8.6,-24.49,;7.1,-24.16,;6.63,-22.7,;2.06,-19.75,;.52,-19.75,)| Show InChI InChI=1S/C47H53N11O7/c48-40(59)28-58-23-22-51-41(60)33-17-7-8-18-34(33)42(61)55-37(24-29-12-3-1-4-13-29)45(64)56-38(25-30-14-5-2-6-15-30)44(63)54-36(20-11-21-52-47(49)50)43(62)57-39(46(58)65)26-31-27-53-35-19-10-9-16-32(31)35/h1-10,12-19,27,36-39,53H,11,20-26,28H2,(H2,48,59)(H,51,60)(H,54,63)(H,55,61)(H,56,64)(H,57,62)(H4,49,50,52)/t36-,37-,38+,39-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Mus musculus) | BDBM50374670
(CHEMBL270923)Show SMILES NC(=O)CN1CCNC(=O)c2ccccc2C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:30.32,wD:52.55,19.20,41.44,(6.67,-17.07,;5.13,-17.07,;4.36,-15.74,;4.37,-18.41,;2.83,-18.41,;2.05,-17.08,;.51,-17.09,;-.25,-18.42,;-1.79,-18.43,;-2.56,-19.76,;-2.57,-17.1,;-1.81,-15.76,;-2.59,-14.43,;-4.14,-14.45,;-4.89,-15.78,;-4.11,-17.1,;-4.87,-18.43,;-6.41,-18.44,;-4.1,-19.76,;-5.43,-20.54,;-6.76,-19.76,;-8.09,-20.54,;-9.42,-19.75,;-10.76,-20.53,;-10.76,-22.07,;-9.41,-22.83,;-8.09,-22.06,;-5.43,-22.08,;-6.76,-22.84,;-4.1,-22.84,;-4.1,-24.38,;-5.43,-25.16,;-5.43,-26.7,;-6.77,-27.46,;-6.77,-28.99,;-5.43,-29.77,;-4.1,-28.99,;-4.1,-27.45,;-2.76,-25.16,;-2.76,-26.7,;-1.42,-24.38,;-.09,-25.16,;-.09,-26.7,;1.24,-27.46,;1.24,-29,;2.58,-29.78,;2.58,-31.32,;3.91,-32.08,;1.24,-32.08,;1.24,-24.38,;2.58,-25.16,;1.24,-22.84,;2.58,-22.08,;3.91,-22.84,;5.24,-22.08,;5.41,-20.53,;6.91,-20.22,;7.67,-21.56,;9.18,-21.89,;9.64,-23.36,;8.6,-24.49,;7.1,-24.16,;6.63,-22.7,;2.06,-19.75,;.52,-19.75,)| Show InChI InChI=1S/C47H53N11O7/c48-40(59)28-58-23-22-51-41(60)33-17-7-8-18-34(33)42(61)55-37(24-29-12-3-1-4-13-29)45(64)56-38(25-30-14-5-2-6-15-30)44(63)54-36(20-11-21-52-47(49)50)43(62)57-39(46(58)65)26-31-27-53-35-19-10-9-16-32(31)35/h1-10,12-19,27,36-39,53H,11,20-26,28H2,(H2,48,59)(H,51,60)(H,54,63)(H,55,61)(H,56,64)(H,57,62)(H4,49,50,52)/t36-,37-,38+,39-/m0/s1 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 550 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC1R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Mus musculus) | BDBM50374669
(CHEMBL406985)Show SMILES NC(=O)CN1CCNC(=O)CCCC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C1=O |wU:27.28,wD:16.16,49.51,38.40,(13.37,-36.69,;12.04,-35.93,;12.04,-34.39,;10.72,-36.69,;10.72,-38.22,;8.06,-38.19,;8.05,-36.66,;9.38,-35.89,;9.37,-34.36,;10.7,-33.58,;8.04,-33.6,;6.71,-34.37,;6.71,-35.91,;5.38,-36.68,;4.04,-35.91,;5.38,-38.22,;4.04,-38.99,;2.71,-38.22,;1.37,-38.99,;.04,-38.21,;-1.29,-38.98,;-1.29,-40.52,;.05,-41.29,;1.38,-40.52,;4.04,-40.53,;2.71,-41.3,;5.38,-41.3,;5.38,-42.84,;4.04,-43.61,;4.04,-45.15,;2.7,-45.91,;2.7,-47.45,;4.04,-48.22,;5.38,-47.44,;5.37,-45.91,;6.71,-43.61,;6.71,-45.15,;8.04,-42.84,;9.38,-43.61,;9.38,-45.15,;10.71,-45.92,;10.71,-47.46,;12.05,-48.23,;12.05,-49.77,;13.38,-50.54,;10.71,-50.54,;10.71,-42.84,;12.05,-43.61,;10.71,-41.3,;12.05,-40.53,;13.38,-41.3,;14.72,-40.53,;14.88,-38.98,;16.39,-38.67,;17.14,-40.02,;18.64,-40.35,;19.12,-41.81,;18.08,-42.95,;16.57,-42.62,;16.11,-41.15,;12.05,-38.99,;13.38,-38.22,)| Show InChI InChI=1S/C44H55N11O7/c45-37(56)27-55-22-21-48-38(57)18-9-19-39(58)51-34(23-28-11-3-1-4-12-28)41(60)53-35(24-29-13-5-2-6-14-29)42(61)52-33(17-10-20-49-44(46)47)40(59)54-36(43(55)62)25-30-26-50-32-16-8-7-15-31(30)32/h1-8,11-16,26,33-36,50H,9-10,17-25,27H2,(H2,45,56)(H,48,57)(H,51,58)(H,52,61)(H,53,60)(H,54,59)(H4,46,47,49)/t33-,34-,35+,36-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.46E+3 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC3R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Mus musculus) | BDBM50121900
(Ac-Ser-Try-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pr...)Show SMILES CCCC[C@H](NC(=O)C(CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@@H]1C(=O)N[C@H](C(C)C)C(N)=O Show InChI InChI=1S/C78H111N21O19/c1-5-6-19-52(91-75(116)61(41-101)97-72(113)57(34-46-24-26-49(103)27-25-46)94-74(115)60(40-100)88-44(4)102)68(109)92-54(28-29-64(105)106)70(111)96-59(36-48-38-83-42-87-48)73(114)93-56(33-45-16-8-7-9-17-45)71(112)90-53(22-14-31-84-78(81)82)69(110)95-58(35-47-37-85-51-20-11-10-18-50(47)51)67(108)86-39-63(104)89-55(21-12-13-30-79)77(118)99-32-15-23-62(99)76(117)98-65(43(2)3)66(80)107/h7-11,16-18,20,24-27,37-38,42-43,52-62,65,85,100-101,103H,5-6,12-15,19,21-23,28-36,39-41,79H2,1-4H3,(H2,80,107)(H,83,87)(H,86,108)(H,88,102)(H,89,104)(H,90,112)(H,91,116)(H,92,109)(H,93,114)(H,94,115)(H,95,110)(H,96,111)(H,97,113)(H,98,117)(H,105,106)(H4,81,82,84)/t52-,53-,54-,55-,56+,57-,58-,59-,60-,61?,62+,65+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0970 | n/a | n/a | n/a | n/a |
The Hebrew University of Jerusalem
Curated by ChEMBL
| Assay Description
Agonist activity at mouse MC4R expressed in HEK293 cells |
J Med Chem 51: 1026-34 (2008)
Article DOI: 10.1021/jm701093y
BindingDB Entry DOI: 10.7270/Q29W0GC3 |
More data for this
Ligand-Target Pair | |
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