Found 91 hits with Last Name = 'laughton' and Initial = 'd' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
CTP synthase 2
(Rattus norvegicus) | CHEMBL5267968
| KEGG
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Myeloperoxidase
(Homo sapiens (Human)) | BDBM217354
(2-(3,5-bistrifluoromethylbenzylamino)-6-oxo-1H-pyr...)Show SMILES ONC(=O)c1cnc(NCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[nH]c1=O Show InChI InChI=1S/C14H10F6N4O3/c15-13(16,17)7-1-6(2-8(3-7)14(18,19)20)4-21-12-22-5-9(10(25)23-12)11(26)24-27/h1-3,5,27H,4H2,(H,24,26)(H2,21,22,23,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 5.01 | n/a | n/a | n/a | n/a | 6.5 | n/a |
University of Otago Christchurch
| Assay Description Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta... |
J Biol Chem 288: 36636-47 (2013)
Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
CTP synthase 1
(Homo sapiens) | CHEMBL5267968
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 2
(Homo sapiens) | CHEMBL5283284
| MMDB
NCI pathway Reactome pathway KEGG
B.MOAD GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 1
(Mus musculus) | CHEMBL5267968
| KEGG
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 2
(Homo sapiens) | CHEMBL5267968
| MMDB
NCI pathway Reactome pathway KEGG
B.MOAD GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413241
(CHEMBL513412)Show SMILES COc1ccc(N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)C(=O)c2occc2C)c(OC)c1 |r| Show InChI InChI=1S/C25H27FN2O6/c1-15-11-12-34-23(15)25(31)28(20-10-9-17(32-3)13-21(20)33-4)22(24(30)27-14-16(2)29)18-7-5-6-8-19(18)26/h5-13,16,22,29H,14H2,1-4H3,(H,27,30)/t16-,22?/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19.9 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilization |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
CTP synthase 2
(Rattus norvegicus) | CHEMBL5283284
| KEGG
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Myeloperoxidase
(Homo sapiens (Human)) | BDBM217355
(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)Show InChI InChI=1S/C14H13NO3/c16-13-9-11(6-7-12(13)14(17)15-18)8-10-4-2-1-3-5-10/h1-7,9,16,18H,8H2,(H,15,17) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | 6.5 | n/a |
University of Otago Christchurch
| Assay Description Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta... |
J Biol Chem 288: 36636-47 (2013)
Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH |
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413240
(CHEMBL471412)Show SMILES COc1ccc(N(C(C(=O)NC2CCCC2)c2ccccc2F)C(=O)c2ccccc2)c(OC)c1 Show InChI InChI=1S/C28H29FN2O4/c1-34-21-16-17-24(25(18-21)35-2)31(28(33)19-10-4-3-5-11-19)26(22-14-8-9-15-23(22)29)27(32)30-20-12-6-7-13-20/h3-5,8-11,14-18,20,26H,6-7,12-13H2,1-2H3,(H,30,32) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilization |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
CTP synthase 1
(Mus musculus) | CHEMBL5283284
| KEGG
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 2
(Mus musculus) | CHEMBL5267968
| Reactome pathway KEGG
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413240
(CHEMBL471412)Show SMILES COc1ccc(N(C(C(=O)NC2CCCC2)c2ccccc2F)C(=O)c2ccccc2)c(OC)c1 Show InChI InChI=1S/C28H29FN2O4/c1-34-21-16-17-24(25(18-21)35-2)31(28(33)19-10-4-3-5-11-19)26(22-14-8-9-15-23(22)29)27(32)30-20-12-6-7-13-20/h3-5,8-11,14-18,20,26H,6-7,12-13H2,1-2H3,(H,30,32) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31.6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Displacement of [Alexa647]C5a from human recombinant C5a receptor expressed in HEK cells by membrane binding assay in presence of [35S]GTPgammaS |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
CTP synthase 1
(Homo sapiens) | CHEMBL5283284
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 2
(Mus musculus) | CHEMBL5283284
| Reactome pathway KEGG
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 2
(Rattus norvegicus) | CHEMBL5277468
| KEGG
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413239
(CHEMBL472268)Show SMILES COc1ccc(N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)C(=O)c2ccoc2C)c(OC)c1 |r| Show InChI InChI=1S/C25H27FN2O6/c1-15(29)14-27-24(30)23(19-7-5-6-8-20(19)26)28(25(31)18-11-12-34-16(18)2)21-10-9-17(32-3)13-22(21)33-4/h5-13,15,23,29H,14H2,1-4H3,(H,27,30)/t15-,23?/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 39.8 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilization |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413240
(CHEMBL471412)Show SMILES COc1ccc(N(C(C(=O)NC2CCCC2)c2ccccc2F)C(=O)c2ccccc2)c(OC)c1 Show InChI InChI=1S/C28H29FN2O4/c1-34-21-16-17-24(25(18-21)35-2)31(28(33)19-10-4-3-5-11-19)26(22-14-8-9-15-23(22)29)27(32)30-20-12-6-7-13-20/h3-5,8-11,14-18,20,26H,6-7,12-13H2,1-2H3,(H,30,32) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 39.8 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Displacement of [Alexa647]C5a from human recombinant C5a receptor expressed in HEK cells by whole cell binding assay |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
Lactoperoxidase
(Bos taurus (Bovine)) | BDBM217355
(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)Show InChI InChI=1S/C14H13NO3/c16-13-9-11(6-7-12(13)14(17)15-18)8-10-4-2-1-3-5-10/h1-7,9,16,18H,8H2,(H,15,17) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago Christchurch
| Assay Description The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ... |
J Biol Chem 288: 36636-47 (2013)
Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH |
More data for this Ligand-Target Pair | |
CTP synthase 1
(Homo sapiens) | CHEMBL5277468
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 1
(Mus musculus) | CHEMBL5277468
| KEGG
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Thyroid peroxidase
(Homo sapiens (Human)) | BDBM217355
(4-benzyl-2-hydroxybenzenecarbohydroxamic acid (HX2...)Show InChI InChI=1S/C14H13NO3/c16-13-9-11(6-7-12(13)14(17)15-18)8-10-4-2-1-3-5-10/h1-7,9,16,18H,8H2,(H,15,17) | UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago Christchurch
| Assay Description The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ... |
J Biol Chem 288: 36636-47 (2013)
Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH |
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413238
(CHEMBL511782)Show SMILES COc1ccc(N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)C(=O)c2ccccc2)c(OC)c1 |r| Show InChI InChI=1S/C26H27FN2O5/c1-17(30)16-28-25(31)24(20-11-7-8-12-21(20)27)29(26(32)18-9-5-4-6-10-18)22-14-13-19(33-2)15-23(22)34-3/h4-15,17,24,30H,16H2,1-3H3,(H,28,31)/t17-,24?/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 63.1 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilization |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413247
(CHEMBL472455)Show SMILES COc1ccc(N(C(C(=O)NC2CCCC2)c2ccccc2F)C(=O)c2ccco2)c(OC)c1 Show InChI InChI=1S/C26H27FN2O5/c1-32-18-13-14-21(23(16-18)33-2)29(26(31)22-12-7-15-34-22)24(19-10-5-6-11-20(19)27)25(30)28-17-8-3-4-9-17/h5-7,10-17,24H,3-4,8-9H2,1-2H3,(H,28,30) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Displacement of [Alexa647]C5a from human recombinant C5a receptor expressed in HEK cells by whole cell binding assay |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413252
(CHEMBL469727)Show SMILES COCc1ccoc1C(=O)N(C(C(=O)NC[C@@H](C)O)c1ccccc1F)c1ccc(OC)cc1OC |r| Show InChI InChI=1S/C26H29FN2O7/c1-16(30)14-28-25(31)23(19-7-5-6-8-20(19)27)29(21-10-9-18(34-3)13-22(21)35-4)26(32)24-17(15-33-2)11-12-36-24/h5-13,16,23,30H,14-15H2,1-4H3,(H,28,31)/t16-,23?/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilization |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413245
(CHEMBL469535)Show SMILES COc1ccc(N(C(C(=O)NC[C@H](C)O)c2ccccc2F)C(=O)c2ccccc2)c(OC)c1 |r| Show InChI InChI=1S/C26H27FN2O5/c1-17(30)16-28-25(31)24(20-11-7-8-12-21(20)27)29(26(32)18-9-5-4-6-10-18)22-14-13-19(33-2)15-23(22)34-3/h4-15,17,24,30H,16H2,1-3H3,(H,28,31)/t17-,24?/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilization |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
CTP synthase 2
(Mus musculus) | CHEMBL5277468
| Reactome pathway KEGG
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 113 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413247
(CHEMBL472455)Show SMILES COc1ccc(N(C(C(=O)NC2CCCC2)c2ccccc2F)C(=O)c2ccco2)c(OC)c1 Show InChI InChI=1S/C26H27FN2O5/c1-32-18-13-14-21(23(16-18)33-2)29(26(31)22-12-7-15-34-22)24(19-10-5-6-11-20(19)27)25(30)28-17-8-3-4-9-17/h5-7,10-17,24H,3-4,8-9H2,1-2H3,(H,28,30) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilization |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
CTP synthase 1
(Homo sapiens) | CHEMBL5288271
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413251
(CHEMBL469728)Show SMILES COc1ccc(N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)C(=O)c2occc2Cl)c(OC)c1 |r| Show InChI InChI=1S/C24H24ClFN2O6/c1-14(29)13-27-23(30)21(16-6-4-5-7-18(16)26)28(24(31)22-17(25)10-11-34-22)19-9-8-15(32-2)12-20(19)33-3/h4-12,14,21,29H,13H2,1-3H3,(H,27,30)/t14-,21?/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilization |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
CTP synthase 1
(Homo sapiens) | CHEMBL5275093
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 2
(Rattus norvegicus) | CHEMBL5288393
| KEGG
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 235 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 2
(Homo sapiens) | CHEMBL5277468
| MMDB
NCI pathway Reactome pathway KEGG
B.MOAD GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 242 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 1
(Homo sapiens) | CHEMBL5291055
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413247
(CHEMBL472455)Show SMILES COc1ccc(N(C(C(=O)NC2CCCC2)c2ccccc2F)C(=O)c2ccco2)c(OC)c1 Show InChI InChI=1S/C26H27FN2O5/c1-32-18-13-14-21(23(16-18)33-2)29(26(31)22-12-7-15-34-22)24(19-10-5-6-11-20(19)27)25(30)28-17-8-3-4-9-17/h5-7,10-17,24H,3-4,8-9H2,1-2H3,(H,28,30) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Displacement of [Alexa647]C5a from human recombinant C5a receptor expressed in HEK cells by membrane binding assay in presence of [35S]GTPgammaS |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413250
(CHEMBL513370)Show SMILES COc1ccc(N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)C(=O)c2ccoc2Cl)c(OC)c1 |r| Show InChI InChI=1S/C24H24ClFN2O6/c1-14(29)13-27-23(30)21(16-6-4-5-7-18(16)26)28(24(31)17-10-11-34-22(17)25)19-9-8-15(32-2)12-20(19)33-3/h4-12,14,21,29H,13H2,1-3H3,(H,27,30)/t14-,21?/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilization |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
Lactoperoxidase
(Bos taurus (Bovine)) | BDBM50015089
(2,N-Dihydroxy-benzamide | CHEMBL309339 | N,2-dihyd...)Show InChI InChI=1S/C7H7NO3/c9-6-4-2-1-3-5(6)7(10)8-11/h1-4,9,11H,(H,8,10) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Otago Christchurch
| Assay Description The halogenation activities of LPO (EC 1.11.1.7) and TPO (EC 1.11.1.8) were determined using a modified method of that described previously [Ferrari ... |
J Biol Chem 288: 36636-47 (2013)
Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
CTP synthase 1
(Homo sapiens) | CHEMBL5270156
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 1
(Homo sapiens) | CHEMBL5288933
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 1
(Homo sapiens) | CHEMBL5288354
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 1
(Mus musculus) | CHEMBL5288393
| KEGG
GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 1
(Homo sapiens) | CHEMBL5287919
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 1
(Homo sapiens) | CHEMBL5284514
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 1
(Homo sapiens) | CHEMBL5288393
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
CTP synthase 2
(Homo sapiens) | CHEMBL5288393
| MMDB
NCI pathway Reactome pathway KEGG
B.MOAD GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Myeloperoxidase
(Homo sapiens (Human)) | BDBM217356
(2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxa...)Show InChI InChI=1S/C12H12N4O3/c17-10-9(11(18)16-19)7-14-12(15-10)13-6-8-4-2-1-3-5-8/h1-5,7,19H,6H2,(H,16,18)(H2,13,14,15,17) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | 6.5 | n/a |
University of Otago Christchurch
| Assay Description Assays were performed at 22 °C with 2 nM MPO and 10 μM hydrogen peroxide (H2O2) in 20 mM NaH2PO4 buffer, pH 6.5 containing 140 mM NaCl, 10 mM ta... |
J Biol Chem 288: 36636-47 (2013)
Article DOI: 10.1074/jbc.M113.507756 BindingDB Entry DOI: 10.7270/Q20K27DH |
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413240
(CHEMBL471412)Show SMILES COc1ccc(N(C(C(=O)NC2CCCC2)c2ccccc2F)C(=O)c2ccccc2)c(OC)c1 Show InChI InChI=1S/C28H29FN2O4/c1-34-21-16-17-24(25(18-21)35-2)31(28(33)19-10-4-3-5-11-19)26(22-14-8-9-15-23(22)29)27(32)30-20-12-6-7-13-20/h3-5,8-11,14-18,20,26H,6-7,12-13H2,1-2H3,(H,30,32) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Displacement of [Alexa647]C5a from human recombinant C5a receptor expressed in HEK cells by membrane binding assay |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413249
(CHEMBL450470)Show SMILES COc1ccc(N(C(C(=O)NC2CCCC2)c2ccccc2F)C(C)=O)c(OC)c1 Show InChI InChI=1S/C23H27FN2O4/c1-15(27)26(20-13-12-17(29-2)14-21(20)30-3)22(18-10-6-7-11-19(18)24)23(28)25-16-8-4-5-9-16/h6-7,10-14,16,22H,4-5,8-9H2,1-3H3,(H,25,28) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilization |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |
CTP synthase 1
(Homo sapiens) | CHEMBL5278356
| MMDB
Reactome pathway KEGG
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
C5a anaphylatoxin chemotactic receptor 1
(Homo sapiens (Human)) | BDBM50413248
(CHEMBL513757)Show SMILES COc1ccc(N(C(C(=O)NC(C)CN(C)C)c2ccccc2F)C(=O)c2ccccc2)c(OC)c1 Show InChI InChI=1S/C28H32FN3O4/c1-19(18-31(2)3)30-27(33)26(22-13-9-10-14-23(22)29)32(28(34)20-11-7-6-8-12-20)24-16-15-21(35-4)17-25(24)36-5/h6-17,19,26H,18H2,1-5H3,(H,30,33) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant C5a receptor in HEK cells assessed as inhibition of C5a-induced calcium mobilization |
Bioorg Med Chem Lett 19: 1143-7 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.104 BindingDB Entry DOI: 10.7270/Q2Q241G1 |
More data for this Ligand-Target Pair | |